Resumen de: US2023079720A1

A device for continuously monitoring glucose levels in a patient is disclosed. The device includes a glucose electronics assembly and a glucose lead assembly in electrical communication with the glucose electronics assembly. The glucose electronics assembly is configured to be positioned in the subcutaneous tissue and the glucose lead assembly is configured to be positioned in a vessel of the patient. The glucose lead assembly has a central shaft, a first electrode in physical communication with the central shaft, a second electrode in physical communication with the central shaft, a third electrode in physical communication with the central shaft and a positioning element configured to have an undeployed state and a deployed state. In the undeployed state, the positioning element is substantially linear, and in the deployed state, the positioning element extends away from the central shaft.

Resumen de: US2023083779A1

The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

Resumen de: WO2023038254A1

The present invention relates to a method and apparatus for non-invasive estimation of glycated hemoglobin (HbA1c) or blood glucose by using machine learning, the method comprising: a signal collection step of collecting a biosignal of a subject to be measured; a feature extraction step of extracting a plurality of features from the biosignal; a machine learning model construction step of constructing a machine learning model for estimating glycated hemoglobin or blood glucose by learning training data including the plurality of features; and a glycated hemoglobin/blood glucose estimation step of generating input data on the basis of the biosignal extracted from the subject being measured and inputting the input data to the machine learning model, so as to estimate glycated hemoglobin or blood glucose of the subject being measured.

Resumen de: US2023081150A1

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Resumen de: US2023082544A1

Disclosed herein are an aqueous pharmaceutical formulation comprising cagrilintide and an aqueous formulation comprising semaglutide. The compositions of these two pharmaceutical formulations allow for their presentation in, and administration using, the dual-chamber medical device disclosed herein. Individuals with diseases, such as diabetes and/or obesity and/or related co-morbidities, may benefit from the co-administration of semaglutide and cagrilintide, and/or of the two liquid pharmaceutical formulations disclosed herein, using the medical device disclosed herein.

Resumen de: US2023085555A1

Provided herein is a non-invasive device for measuring glucose levels (i.e., concentration) in a subject, preferably a human subject. The present invention relates to a wearable device, a kit and a method thereof for measuring blood glucose concentrations/levels. The non-invasive devices of the present invention can be used as wearable devices such as a smart band, ring, bracelet, watch and the like to monitor the blood glucose levels in diabetics without discomfort and stress due to finger pricks by measuring bio-impedance data.

Resumen de: US2023080129A1

A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.

Resumen de: US2023084613A1

In general, regardless of using an optical method or an electrical AC resistance impedance method, non-invasive blood glucose measurement has a problem in that variations in the level of glucose contained in blood are too small to be measured as a signal, and thus measurement results are inaccurate due to noises generated during measurement and errors caused by the difficulty in consistent measurement. To solve this problem, the present invention provides a non-invasive blood glucose sensor includes: a measurement-unit body; an impedance electrode sensor provided on an inner bottom surface of the measurement-unit body; a signal-generation and measurement unit configured to measure impedance while scanning frequency by supplying multiple frequencies to the impedance electrode sensor; a blood sensor configured to measure the amount of blood flowing through a body part brought into contact with the impedance electrode sensor; and a status display LED configured to display different colors according to the amount of blood measured using the blood sensor. Owing to this configuration, the present invention has an effect of measuring an accurate blood glucose level in a non-invasive manner.

Resumen de: GB2610612A

A wearable sensor device 100 for detecting a biological/physiological parameter (e.g. blood glucose, heart rate, blood pressure, respiration rate) of biological material 105 comprises a support structure 110 having a measurement region 115, and a radiofrequency (RF) element 130 and optical sensor 120 to respectively receive an RF signal and an optical signal 121 from the biological material 131 via the measurement region. The RF element is positioned between the optical sensor and the measurement region such that the optical sensor receives the optical signal through the RF element. The biological material is irradiated with RF radiation and optical radiation. The sensor may be worn on the skin web between a finger and thumb, earlobe, armpit, wrist or lip. The sensor may be a smartwatch 210 or smart bracelet. Additional sensors (e.g. temperature, motion, pressure) may be provided, and measurements used in combination with the optical and RF signals to determine the biological parameter.

Resumen de: EP4147999A1

Embodiments described herein relate to a glucose monitoring system having a glucose sensor positioned in contact with interstitial fluid in a body of a user. A transmitter unit is coupled to the glucose sensor and processes data indicative of a plurality of monitored glucose levels from the glucose sensor. A receiver unit receives the processed data from the transmitter unit. The receiver unit comprises a processor and a user interface having a touch-sensitive display to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displaying the plurality of monitored glucose levels, a second panel simultaneously displaying a current glucose level and a glucose trend indicator, and a third panel displays status information of a plurality of components of the system. When an alarm condition is detected, the display renders the alert screen in place of one of the first panel, the second panel, or the third panel. The alert screen displays information corresponding to the detected alarm condition. The display affects a further output corresponding to the detected condition in response to user actuation of a portion of the display.

Resumen de: EP4148402A1

Various embodiments of a user-wearable device can comprise a frame configured to mount on a user. The device can include a display attached to the frame and configured to direct virtual images to an eye of the user. The device can also include a light source configured to provide polarized light to the eye of the user and that the polarized light is configured to reflect from the eye of the user. The device can further include a light analyzer configured to determine a polarization angle rotation of the reflected light from the eye of the user such that a glucose level of the user can be determined based at least in part on the polarization angle rotation of the reflected light.

Resumen de: US2023076499A1

The present disclosure relates to a method for transmitting/receiving biometric information in a continuous glucose monitoring system, and more specifically, to a method for transmitting/receiving biometric information, in which, in each communication cycle, first, an identifier of the last transmit packet received by a communication terminal is transmitted to a sensor transmitter, and the sensor transmitter transmits, to the communication terminal, a transmit packet generated after the last transmit packet, and thus biometric information generated by the sensor transmitter may be transmitted without loss to the communication terminal.

Resumen de: US2023074713A1

An electronic device may include a housing and a PhotoPlethysmoGram (PPG) sensor disposed inside the housing. The PPG sensor may include a first Light Emitting Diode (LED) configured to generate light in a first wavelength band, a second LED configured to generate light in a second wavelength band, a third LED configured to generate light in a third wavelength band, a fourth LED configured to generate light in a fourth wavelength band, and a light receiving module including at least one photo diode. The electronic device may include a processor operatively coupled with the PPG sensor and a memory operatively coupled with the processor. The memory may include instructions that, when executed, cause the processor to measure optical densities of the light generated by the first LED to the fourth LED, and calculate a blood glucose value based at least in part on the measured optical densities.

Resumen de: US2023074154A1

A physiological characteristic monitoring system includes a wearable attachment device, an electronic device, and a physiological characteristic sensor (e.g., a glucose sensor) including a portion that is insertable into subcutaneous tissue of a user to generate sensor signals indicating a physiological characteristic of the user. The electronic device includes a first connector configured to detachably couple to the physiological characteristic sensor to receive the sensor signals in a first configuration of the electronic device, a second connector configured to detachably couple to the wearable attachment device in a second configuration of the electronic device, a controller configured to determine the physiological characteristic of the user based on the sensor signals, and a display configured to display the physiological characteristic of the user.

Resumen de: US2023070694A1

A device that non-invasively detects objects beneath or around the foot or a foot position and transmits signals which are processed and then output via an output device on a skin surface not affected by a neurological deficit, such as the hands or thighs. This device is suitable for subjects with diabetic neuropathy who have lost sensation in their feet and are at risk of punctures, cuts or other physical damage and at risk of sprains, strains or falls due to lack of an ability to detect objects underfoot and foot position.

Resumen de: US2023071306A1

A computer-assisted medical device is configured and used to endoluminally navigate to a location in the gastrointestinal system and there treat certain body lumen wall areas while avoiding other body lumen wall areas. Embodiments ablate the inner mucosal layer and sub-mucosal nerve plexus of the stomach, duodenum and jejunum to effect treatment of insulin resistance and metabolic disorders, such as Type II diabetes (T2D), polycystic ovarian syndrome (PCOS), non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), congestive heart failure (CHF) and obstructive sleep apnea (OSA). Various sensors are used to assist a clinical operator to navigate from the mouth through the pyloric sphincter and into and through the duodenum and/or jejunum. Various sensors are used to map and identify portions of the duodenum and/or jejunum. Various lumen wall ablation devices and methods are described. Various post-treatment assessments are described.

Resumen de: US2023072282A1

A method of manufacturing a copper oxide (CuxO) structure onto a Copper (Cu) surface by fabricating an electroactive hierarchical CuxO structure directly onto the Cu surface by laser-induced oxidation (LIO). The generated heat from the laser source provides energy for the oxidation of the Cu surface in the presence of atmospheric oxygen. The electroactive hierarchical CuxO structure is a binder-free nanotextured structure. The electroactive hierarchical CuxO structure may be used as a glucose sensor.

Resumen de: US2023072422A1

Analyte sensing and response systems include a sensor detecting one or more analytes in a medium. The sensor uses decoupled transmit and receive elements or antennas to transmit a signal into the medium, and receive a response to the transmitted signal. An action that is based on the detection of the analyte is generated which can directly or indirectly affect the detected analyte in the medium. The action is automatically performed. The action can be increasing or decreasing flow from a source of the analyte, or of a chemical compound interacting with the analyte. An example of the action is controlling an insulin pump, where the analyte is glucose.

Resumen de: US2023074956A1

Method and system for providing basal profile modification in insulin therapy for use with infusion devices includes periodically monitoring the analyte levels of a patient for a predetermined period of time in order to determine, based on the monitored analyte levels, an appropriate modification factor to be incorporated into the underlying basal profile which was running at the time the periodic monitoring of the analyte levels were performed.

Resumen de: US2023074949A1

The title of the invention is the remote sensing of physiological dynamics electromagnetic big data, the related technology belongs to the field of remote sensing of physiology or psychology. The technical problem to be solved by the present invention is the remote sensing of physiological or psychological electromagnetic dynamics of human, animal or plant individuals, the related electromagnetic media could be nucleon, electron, atom, molecule, ion, water, fluid, blood, DNA, RNA, amino acid, sugar, fat, protein, cell, tissue, organ, bone, fruit, flower, leave, stem, bark, and root, etc., the 30 μm-1000 million meters band electromagnetic waves could be used to extract the reflection spectra of partial or entire human, animal or plant individual electromagnetic media in different physiology or psychology states, single or multiple sensitive wavelengths or wavebands of spectrum troughs could be chosen as the electromagnetic wave probes, which could be used to irradiate partial or entire human, animal or plant individual electromagnetic media and extract the reflection waves, the electromagnetic dynamics of the human, animal or plant individuals in different physiology or psychology states could be transformed to the different electromagnetic indexes, such as the frequency, reflection rate and phase values, the major applications of the invention might be the drunk driving, fatigue driving, road rage driving, big data and big ecology, etc.

Resumen de: US2023074650A1

The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used disposables, thereby allowing accurate and safe use and convenient maintenance.

Resumen de: US2023074617A1

A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor. Instead, data received from the continuous analyte sensor is used to provide alarms to the user when the analyte concentration and/or the rate of change of analyte concentration, as measured by the continuous analyte sensor, is above or below a predetermined range. Data received from the continuous analyte sensor may also be used to prompt the diabetic or caregiver to take certain actions, such as to perform another single point blood glucose measurement. In another embodiment, the device provides for toggling between two modes, with one mode that allows for display of glucose concentration values associated with the continuous glucose sensor and a second mode that prevents the display of glucose concentration values associated with the continuous glucose sensor.

Resumen de: WO2023030023A1

The present invention relates to a method for preparing a multifunctional hydrogel by means of yeast fermentation. The method of the present invention comprises: first reducing graphene oxide by using polydopamine to obtain a reduced graphene oxide solution, and then preparing a gelatin PCA glucose mixed solution having a certain concentration and an activated yeast solution; and mixing the three solutions by means of a one-pot reaction method, stirring evenly, pouring the mixture into a mold, and fermenting in a water bath at 30°C for a certain period of time to obtain a Gel-PrGO-PCA-yeast multifunctional hydrogel material. The method is simple, convenient, rapid and efficient, and the obtained hydrogel has good breathability, super-strong mechanical performance, conductivity and biocompatibility and can be applied to different skin positions to detect electrocardiograms and electromyograms. The present invention provides a new thought and method for preparing a porous breathable conductive hydrogel electrode, and is beneficial to the development and utilization of a conductive hydrogel material, so that the conductive hydrogel material can be used in the field of biosensors.

Resumen de: WO2023034542A1

There is provided a glucose sensor system comprising: a transmitter (2) for containing a battery (212), the transmitter being for placement on top of patient skin; a transcutaneous connector (3) comprising at least one conductive path; and an implantable monolithic integrated circuit (1) for placement beneath the patient skin, wherein the implantable monolithic integrated circuit comprises a potentiostat and an electrochemical sensing element; wherein the potentiostat is electrically coupled to the transmitter (2) via the transcutaneous connector (3), and the electrochemical sensing element is configured to sense glucose concentration and generate an electrical signal representative of the glucose concentration, and wherein the potentiostat is electrically connected to the electrochemical sensing element.

Resumen de: WO2023034820A1

Systems and methods for predictive glucose in accordance with embodiments of the invention are illustrated. One embodiment includes glucose management device, including a brain signal recorder, and a controller, including a processor, and a memory, the memory containing a glucose monitoring application configured to direct the processor to record a brain activity signal of a user's brain using the brain signal recorder, and decode the brain activity signal to predict future glucose levels of the patient.