Absstract of: US2023091490A1

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Absstract of: US2023087860A1

A method of managing insulin includes receiving blood glucose measurements on a computing device from a glucometer. The blood glucose measurements are separated by a time interval. The method includes determining, by the computing device, an insulin dose rate based on the blood glucose measurements and determining a blood glucose drop rate based on the blood glucose measurements and the time interval. The method also includes determining a blood glucose percentage drop based on the blood glucose measurements. The method includes decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose drop rate is greater than a threshold drop rate, and decreasing the time interval between blood glucose measurements by the glucometer when the blood glucose percentage drop is greater than a threshold percentage drop.

Absstract of: US2023088060A1

The present disclosure relates to a continuous glucose monitoring apparatus, and provides a continuous glucose monitoring apparatus of which a body-attachment unit starts operating, in a state in which the body-attachment unit is inside an applicator, by the supply of power to the body-attachment unit through a user operation, such as separation and removal of a protective cap, so that the operating start time point of the body-attachment unit is formed by means of the user operation immediately before the body-attachment unit is inserted into and attached to the human body, thereby enabling the body-attachment unit to start operating at an appropriate point in time, the body-attachment unit starts operating only by simply removing the protective cap even without performing separate additional work for starting operation of the body-attachment unit, thereby improving use convenience, and an operating method for a power supply switch means that supplies battery power to the body-attachment unit is formed as various methods that are linked with a separation and removal operation of the protective cap, and thus manufacturing and use convenience can be further improved.

Absstract of: AU2023201017A1

Systems and methods for integrating a continuous glucose sensor 12, including a receiver 14, a medicament delivery device 16, a controller module, and optionally a single point glucose monitor 18 are provided. Integration may be manual, semi-automated and/or fully automated.

Absstract of: WO2023040925A1

Provided in the present invention is a glucose monitoring system for a glucose concentration level, which system is a glucose monitoring system used for measuring the glucose concentration of an object to be tested and providing guidance information. The glucose monitoring system comprises a sensing module, a communication module and a processing module, wherein the sensing module is configured to detect glucose data of said object, the glucose data comprising the glucose concentration of said object, which glucose concentration changes over time within a time interval within which a test is to be performed; the communication module is configured to receive the glucose data and send same to the processing module; and the processing module is configured to determine a fluctuation type of the glucose concentration on the basis of the glucose data, the fluctuation type reflecting a change trend of the glucose concentration within said time interval, and to generate, according to the fluctuation type, guidance information suggestions related to a diet behavior, an exercise behavior and a sleep behavior. In this way, fluctuation features can be analyzed according to a dynamic glucose curve, and help can be provided for said object and a doctor in terms of rapidly and accurately reading a report, and suggestion or guidance information related to a diet behavior, a sleep behavior or an exercise behavior can be provided.

Absstract of: WO2023044347A1

A device for continuously monitoring glucose levels in a patient is disclosed. The device includes a glucose electronics assembly and a glucose lead assembly in electrical communication with the glucose electronics assembly. The glucose electronics assembly is configured to be positioned in the subcutaneous tissue and the glucose lead assembly is configured to be positioned in a vessel of the patient. The glucose lead assembly has a central shaft, a first electrode in physical communication with the central shaft, a second electrode in physical communication with the central shaft, a third electrode in physical communication with the central shaft and a positioning element configured to have an undeployed state and a deployed state. In the undeployed state, the positioning element is substantially linear, and in the deployed state, the positioning element extends away from the central shaft.

Absstract of: US2023093665A1

Analyte sensors and methods for fabricating analyte sensors in a roll-to-roll process are provided. In an exemplary embodiment, a method includes providing a roll of a polyester substrate having a first side coated with a layer of platinum, wherein the platinum is in direct contact with the polyester substrate; patterning the layer of platinum to form electrodes; punching the polyester substrate to form ribbons, wherein each ribbon is connected to a remaining polyester substrate web by a tab, and wherein each sensor includes an electrode; after punching the polyester substrate to form ribbons, depositing an enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane; after depositing the enzyme layer over the portions of the working electrodes and coating the working electrodes with a glucose limiting membrane, singulating the individual sensors by completely separating each individual sensor from the polyester substrate.

Absstract of: US2023092485A1

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Absstract of: WO2023043553A1

A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.

Absstract of: CN111939386A

The invention discloses a double-side-driven multi-infusion-mode medicine infusion device. The double-side-driven multi-infusion-mode medicine infusion device comprises a medicine storage unit, a piston, a driving wheel, a driving unit and a power unit; the piston and the driving wheel are respectively connected with a screw rod; the driving wheel is provided with wheel teeth; the driving wheel pushes the screw rod to move through rotation; the piston is arranged in the medicine storage unit; the screw rod pushes the piston to move; the driving unit is matched with the driving wheel to operate; the power unit is connected with the driving unit, and applies forces in two different directions to the driving unit, so that the driving unit has multiple different operation modes; and therefore,the infusion device has multiple different unit infusion amounts or infusion rates. The driving unit has multiple operation modes; therefore, multi-gear pushing of the driving wheel is achieved; theinfusion device has multiple infusion modes; and thus, the infusion efficiency is greatly improved.

Absstract of: EP4151150A1

Systems, methods and apparatus are provided for estimating meal start and peak meal response times are provided based on time series of sampled glucose data collected. Numerous additional aspects are disclosed.

Absstract of: CN111939386A

The invention discloses a double-side-driven multi-infusion-mode medicine infusion device. The double-side-driven multi-infusion-mode medicine infusion device comprises a medicine storage unit, a piston, a driving wheel, a driving unit and a power unit; the piston and the driving wheel are respectively connected with a screw rod; the driving wheel is provided with wheel teeth; the driving wheel pushes the screw rod to move through rotation; the piston is arranged in the medicine storage unit; the screw rod pushes the piston to move; the driving unit is matched with the driving wheel to operate; the power unit is connected with the driving unit, and applies forces in two different directions to the driving unit, so that the driving unit has multiple different operation modes; and therefore,the infusion device has multiple different unit infusion amounts or infusion rates. The driving unit has multiple operation modes; therefore, multi-gear pushing of the driving wheel is achieved; theinfusion device has multiple infusion modes; and thus, the infusion efficiency is greatly improved.

Absstract of: EP4151251A1

The invention discloses a bilaterally driven intelligent control infusion device, comprising: infusion unit, the infusion unit comprises a drug storage unit, a piston and a rigid screw, the piston is arranged in the drug storage unit, a metal piece arranged on the piston, fixedly connected to the rigid screw; a driving wheel, provided with wheel teeth, drives the screw movement by rotation, the screw advances the piston to move; a driving unit cooperating with the driving wheel; and a power unit, connected to the driving unit, outputs forces in two different directions on the driving unit to lead driving unit to pivot ;a position detector, interacted with the metal piece to generate signal; a program unit, connected to the infusion unit, convert the received signal into the piston position information and can control the driving unit to operate with different infusion rate according to requirements. The bilaterally driven intelligent control infusion device can be operated with multiple infusion rate, which improves the flexibly of the infusion process, and the driving unit has multiple-mode operation, thus realizing driving the driving wheel in multiple-mode rotations and making the infusion device have multiple infusion modes, which improves the infusion efficiency significantly.

Absstract of: WO2021012075A1

The invention discloses an integrated drug infusion device, comprising: infusion unit configured to deliver drugs; program unit comprising input end and output end, and the input end comprises a plurality of electrically connective regions for receiving signals of analyte data in the body fluid, after the output end is electrically connected to the infusion unit, according to the received signals of analyte data in the body fluid, the program unit controls whether the infusion unit delivers drugs; an infusion cannula with conductive area (s), the infusion cannula is the drug infusion channel; and a plurality of electrodes for detecting analyte data in body fluid, the electrode comprising conductive-area electrode (s) and cannula-wall electrode (s), the conductive area of the infusion cannula being at least as a conductive-area electrode, and one or more cannula-wall electrodes being located on/in the wall of the infusion cannula. It takes only one insertion to perform both analyte detection and drug infusion.

Absstract of: EP4152003A1

Systems and methods for multiple analyte analysis are provided. In one embodiment, a method includes determining concentrations of first and second analytes in a sample. The first and second analytes may be, for example, glucose and hydroxybutyrate. In this form, an indication related to the measured concentration of hydroxybutyrate is provided in response to determining that the concentration of hydroxybutyrate is above a predetermined value. In a further aspect of this form, a quantitative indication representative of the measured glucose concentration is automatically provided regardless of the value of the measured glucose concentration. In another embodiment, a system includes a meter configured to interact with a test element to assess first and second analytes in a sample. Further embodiments, forms, objects, features, advantages, aspects, and benefits shall become apparent from the description and drawings.

Absstract of: US2023085555A1

Provided herein is a non-invasive device for measuring glucose levels (i.e., concentration) in a subject, preferably a human subject. The present invention relates to a wearable device, a kit and a method thereof for measuring blood glucose concentrations/levels. The non-invasive devices of the present invention can be used as wearable devices such as a smart band, ring, bracelet, watch and the like to monitor the blood glucose levels in diabetics without discomfort and stress due to finger pricks by measuring bio-impedance data.

Absstract of: US2023083779A1

The present invention relates to a sensor applicator assembly for a continuous glucose monitoring system and provides a sensor applicator assembly for a continuous glucose monitoring system, which is manufactured with a sensor module assembled inside an applicator, thereby minimizing additional work by a user for attaching the sensor module to the body and allowing the sensor module to be attached to the body simply by operating the applicator, and thus can be used more conveniently. A battery is built in the sensor module and a separate transmitter is connected to the sensor module so as to receive power supply from the sensor module and be continuously used semi-permanently, thereby making the assembly economical. The sensor module and the applicator are used as disposables, thereby allowing accurate and safe use and convenient maintenance.

Absstract of: US2023081150A1

Devices, systems, and methods are provided herein for delivering medication (e.g., insulin) via a wearable pump having a patch-style form factor for adhesion to a user's body. The reusable pump may be coupled to a disposable cap housing a microdosing system for delivering precise, repeatable doses of medication to a cannula configured to deliver medication to a target infusion area beneath the user's outer skin layer. The system further may include an applicator for inserting the cannula into the user's skin and/or applying an adhesive pad to the skin.

Absstract of: WO2023038254A1

The present invention relates to a method and apparatus for non-invasive estimation of glycated hemoglobin (HbA1c) or blood glucose by using machine learning, the method comprising: a signal collection step of collecting a biosignal of a subject to be measured; a feature extraction step of extracting a plurality of features from the biosignal; a machine learning model construction step of constructing a machine learning model for estimating glycated hemoglobin or blood glucose by learning training data including the plurality of features; and a glycated hemoglobin/blood glucose estimation step of generating input data on the basis of the biosignal extracted from the subject being measured and inputting the input data to the machine learning model, so as to estimate glycated hemoglobin or blood glucose of the subject being measured.

Absstract of: US2023084613A1

In general, regardless of using an optical method or an electrical AC resistance impedance method, non-invasive blood glucose measurement has a problem in that variations in the level of glucose contained in blood are too small to be measured as a signal, and thus measurement results are inaccurate due to noises generated during measurement and errors caused by the difficulty in consistent measurement. To solve this problem, the present invention provides a non-invasive blood glucose sensor includes: a measurement-unit body; an impedance electrode sensor provided on an inner bottom surface of the measurement-unit body; a signal-generation and measurement unit configured to measure impedance while scanning frequency by supplying multiple frequencies to the impedance electrode sensor; a blood sensor configured to measure the amount of blood flowing through a body part brought into contact with the impedance electrode sensor; and a status display LED configured to display different colors according to the amount of blood measured using the blood sensor. Owing to this configuration, the present invention has an effect of measuring an accurate blood glucose level in a non-invasive manner.

Absstract of: US2023080129A1

A device for determining a glucose level of a patient includes a set of electrodes comprising a first working electrode, a second working electrode, a counter electrode, and a reference electrode. The reference electrode is electrically coupled to the counter electrode. The device further includes a memory and one or more processors implemented in circuitry and in communication with the memory. The one or more processors configured to determine a sensor signal based on current flowing between the first working electrode and the counter electrode and determine an open circuit potential (OCP) signal based on a voltage across the second working electrode and the reference electrode. The one or more processors are further configured to determine the glucose level of the patient based on the sensor signal and the OCP signal and output an indication of the glucose level.

Absstract of: US2023079720A1

A device for continuously monitoring glucose levels in a patient is disclosed. The device includes a glucose electronics assembly and a glucose lead assembly in electrical communication with the glucose electronics assembly. The glucose electronics assembly is configured to be positioned in the subcutaneous tissue and the glucose lead assembly is configured to be positioned in a vessel of the patient. The glucose lead assembly has a central shaft, a first electrode in physical communication with the central shaft, a second electrode in physical communication with the central shaft, a third electrode in physical communication with the central shaft and a positioning element configured to have an undeployed state and a deployed state. In the undeployed state, the positioning element is substantially linear, and in the deployed state, the positioning element extends away from the central shaft.

Absstract of: US2023082544A1

Disclosed herein are an aqueous pharmaceutical formulation comprising cagrilintide and an aqueous formulation comprising semaglutide. The compositions of these two pharmaceutical formulations allow for their presentation in, and administration using, the dual-chamber medical device disclosed herein. Individuals with diseases, such as diabetes and/or obesity and/or related co-morbidities, may benefit from the co-administration of semaglutide and cagrilintide, and/or of the two liquid pharmaceutical formulations disclosed herein, using the medical device disclosed herein.

Absstract of: EP4148402A1

Various embodiments of a user-wearable device can comprise a frame configured to mount on a user. The device can include a display attached to the frame and configured to direct virtual images to an eye of the user. The device can also include a light source configured to provide polarized light to the eye of the user and that the polarized light is configured to reflect from the eye of the user. The device can further include a light analyzer configured to determine a polarization angle rotation of the reflected light from the eye of the user such that a glucose level of the user can be determined based at least in part on the polarization angle rotation of the reflected light.

Absstract of: EP4147999A1

Embodiments described herein relate to a glucose monitoring system having a glucose sensor positioned in contact with interstitial fluid in a body of a user. A transmitter unit is coupled to the glucose sensor and processes data indicative of a plurality of monitored glucose levels from the glucose sensor. A receiver unit receives the processed data from the transmitter unit. The receiver unit comprises a processor and a user interface having a touch-sensitive display to render a plurality of display screens, including a home screen and an alert screen. The home screen is divided into a plurality of simultaneously displayed panels, with a first panel displaying the plurality of monitored glucose levels, a second panel simultaneously displaying a current glucose level and a glucose trend indicator, and a third panel displays status information of a plurality of components of the system. When an alarm condition is detected, the display renders the alert screen in place of one of the first panel, the second panel, or the third panel. The alert screen displays information corresponding to the detected alarm condition. The display affects a further output corresponding to the detected condition in response to user actuation of a portion of the display.