Disclosed are an antiviral composition, a composition for controlling plant viruses, and a method for controlling plant viruses using the composition. Trichodermin or Trichoderminol which is a tricothecene-based compound and is isolated from Trichoderma albolutescenes strain has antiviral activities against various plant viruses and is thus suitable for controlling plant viruses. This description can facilitate mass production of an active component derived from natural products, provide environment-friendly antifungal agents, which do not harm plants, using safe materials, and be variously utilized in agricultural fields, for example, such as production of high-value crops.

The present invention relates to a composition comprising at least one biological control agent selected from the group consisting of Paecilomyces lilacinus strain 251 (AGAL No. 89/030550) and Coniothyrium minitans CON/M/91-08 (DSM 9660) and/or a mutant of these strains having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against nematodes, insects and/or phytopathogens, and at least and at least one further biological control agent (II) which is selected from the group consisting of bacteria in a synergistically effective amount. Furthermore, the present invention relates to a kit of parts comprising said composition and the use of said composition.

A method for preparing a solid Trichoderma seed from direct fermentation of crop straws with Trichoderma, and a product prepared by using the same. The method includes adding a liquid amino acid to the crop straws, adjusting the initial pH to 3.0-4.0, and inoculating a liquid Trichoderma seed for solid fermentation. An acidity that allows Trichoderma to grow and multiply rapidly and inhibits the growth of other non-target fungi is established in the material by adjusting its pH value, an optimum nutritional formula for Trichoderma is screened out, and an inexpensive proprietary process for preparing a solid Trichoderma seed through fermentation is established. 1% of the solid Trichoderma seed is added to a matured compost, which allows the density of Trichoderma spores in the Trichoderma amended bioorganic fertilizer to reach above 5×107 spores/g, and the production increasing effect is considerable after the Trichoderma amended bioorganic fertilizer is applied.

Disclosed are protocols, isolation means, and compositions of matter useful for identifying mesenchymal stem cells possessing enhanced clinical activity. In one embodiment, markers associated with said enhanced mesenchymal stem cell activity are utilized to identify donors whose mesenchymal stem cells possess superior efficacy compared to mesenchymal stem cells from donors who lack said markers associated with said enhanced efficacy. In one embodiment, said markers are utilized to select for mesenchymal stem cells possessing enhanced efficacy from in vitro cultures. In another embodiment, surfaces markers associated with said markers associated with enhanced efficacy are utilized to positively select for cells possessing enhanced efficacy. In another embodiment, the invention teaches markers whose expression is correlated with negative efficacy. Said markers can be utilized to exclude mesenchymal stem cell donors, or in vitro generated and/or isolated mesenchymal stem cells prior to clinical use.

The disclosure provides methods and compositions for affecting the development of antigen presenting cell (APC, e.g., a macrophage or dendritic cell). The methods include maturing an APC, promoting anti-inflammatory phenotype, promoting development of a T regulatory cell (Treg) from a naive T cell. The methods generally include exposing an APC to a tryptophan derived microbiota metabolite (TDMM), such as an anti-inflammatory or pro-mucosal TDMM, and permitting the APC to mature. In some embodiments, the conditioned APC is exposed to a naive T cell to further promote development of a T regulatory cell (Treg). In some embodiments, the TDMM is selected from the group consisting of indole, indole-3-acetate, 5-hydroxyindole, and indole-3-pyruvate.

A perfume composition having controlled release of phytoncides in an atmosphere in order to generate an air condition resembling the air environment of a forest is provided. The perfume composition includes a) at least about 0.6% by weight of at least one phytoncide; and b) a perfume mixture including (i) at least one solvent; and (ii) at least one fragrance ingredient. At least about 25% by weight of the at least one phytoncide is selected from the group consisting of pinene alpha, pinene beta and combinations thereof.

A composition is provided comprising an effective treatment amount of a biorational treatment concentrate comprising one or more plant oils and/or glycerol in combination with a carrier, and one or more colorants and/or one or more active ingredients, wherein the composition is formulated to treat a target crop. Related products and methods of using same are also provided.

Plant-protective compositions comprising lysozyme and methods of their use are provided. Lysozyme is a naturally-derived material forming a desirable non-toxic barrier that eliminates various plant pests and may promoting plant growth. Formulations are provided, which may include carriers, inert ingredients and formulation components, and/or active ingredients. Methods of protecting a plant, plant part, seed, or site where plants are to be grown from a pest using the compositions are also provided. Exemplary plants include those of the Cannabis genus.

Methods and materials for improved in vivo production of dsRNA are presented. Yields of dsRNA are significantly increased in the presence of capsid protein. The improved yield of dsRNA is not dependent on the presence of specific cognate binding sites for capsid protein associated with the dsRNA, but is dependent on capsid protein.

Compositions comprising crosslinked polymers comprising one or more volatile oils and uses same for e.g., food preservation is disclosed.

The present invention provides a novel method of manufacturing germinated plant seeds suitable for producing a large amount of phytoalexin, a method of manufacturing raw material seeds for germination induction for use in manufacture of the above germinated plant seeds, an extract composition of the germinated plant seeds and a screening method for a plant seed candidate for use in producing a target substance. The method of manufacturing raw material seeds for germination induction comprises a pre-treatment step of maintaining plant seeds under atmosphere conditions of a carbon dioxide concentration of 400 ppm or more and/or an oxygen concentration of 19 vol % or less continuously for 5 hours or more.

The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of MU1140 wherein the amino acid at position (1) is changed to Gly, the amino acid at position (4) is changed to an Ala, or the amino acid at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof.

Compositions and methods for affecting dipteran hematophagous parasites. The compositions contain at least one dipteran semiochemical and at least one phagostimulant. The compositions may further include a pesticide. The semiochemical may be a floral attractant and the phagostimulants may be sugar-based. The compositions may be useful in attracting mosquitoes and/or repelling sand flies.

The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.

The present invention relates to a method for prolonging spore viability of fungal spores present in a liquid formulation, comprising (a) packaging said formulation in a suitable container; (b) reducing oxygen exposure of the spores in said formulation as compared to oxygen exposure of said spores when said formulation is in contact with air; and (c) closing or sealing said container. The invention further relates to a closed container comprising a liquid formulation within said container, said formulation comprising fungal spores, wherein the spores in said formulation have reduced oxygen exposure as compared to oxygen exposure of said spores when said formulation is in contact with air.

Compositions and methods for treating and preventing arthropod infestation are disclosed. A method of treating an arthropod infestation in a subject in need thereof, the method comprising administering topically to the subject an effective amount of either an insecticidal composition consisting essentially of at least one essential oil and a pentacyclosiloxane or an insecticidal composition comprising at least one essential oil, a pentacyclosiloxane, and a mineral oil.

The present invention includes compositions and methods for treating one or more pathogens that affect plants comprising: identifying a plant or seed in need of treatment of a plant; obtaining a whole leaf aloe vera extract and adding aloin, wherein the aloe vera leaf is processed to eliminate solids and to preserve the gel of the aloe vera gel; and at least one of diluting the whole leaf aloe vera extract and spraying the whole leaf aloe vera extract on the plant or seed, wherein the aloe vera gel and aloin at least one of stop the growth of, reduce the spread of, or kill the one or more pathogens on the plant or reduce the amount of infected plants that arises from the treatment of seeds.

The present invention refers to a Natural Repellent Against the Aedes aegypti Mosquito of topical use obtained from an O/W type emulsion containing the Hidroalcoholic Extract of Indian Neem leaves (Azadirachta indica A. Juss) and Babassu oil (Orbignya phalerata, Martius), extracted from the fruit kernels mechanically, manually or by solvent, containing an oily phase and an aqueous phase poured at room temperature and presenting slightly yellowish color features, characteristic odor, appearance of cloudy yellow gel-cream, homogeneous and stable after submitted to tests of stability and accelerated stability, which presents repellent action to Aedes sp., Anopheles sp., Culex sp. mosquitoes, besides the common mosquitoes, which also associates moisturizing the skin, in the form of cream-gel.

Strains of Chromobacterium sphagni sp. nov. are described which have insecticidal activity against insect larvae, in general, and lepidopteran insect larvae, in particular. A biocontrol agent containing one or more C. sphagni, media in which the C. sphagni, or both, and optionally a carrier are also described. Methods of killing insect larvae and methods of reducing insect populations in an area by applying to the area or an object an effective amount of the biocontrol agent are also described.

The present invention includes compositions and methods for treating one or more pathogens that affect plants comprising: identifying a plant or seed in need of treatment of a plant; obtaining a whole leaf aloe vera extract and adding aloin, wherein the aloe vera leaf is processed to eliminate solids and to preserve the gel of the aloe vera gel; and at least one of diluting the whole leaf aloe vera extract and spraying the whole leaf aloe vera extract on the plant or seed, wherein the aloe vera gel and aloin at least one of stop the growth of, reduce the spread of, or kill the one or more pathogens on the plant or reduce the amount of infected plants that arises from the treatment of seeds.

This mite-capturing sheet (1) is provided with an adhesive sheet (3) for capturing mites, and a resin sheet (4) that is provided over the adhesive sheet (3) and that contains an attractant. A plurality of resin sheet opening parts (5) for exposing the adhesive sheet (3) are formed in the resin sheet (4).

An edible herbal formulation which raises the alkalinity of the human body in a short period of time is disclosed. The major ingredient in the formulation is Camptotheca. Additional ingredients that may be included are poria cocos, astragalus membranacaus, ostrea vivularis gould, prunella vulgaris, bombyx mori and phellodendron amurense Rupr. While the herbal formulation may be a mixture containing Camptotheca and all or some of the above ingredients, it is most preferred that the herbal formulation include the three ingredients of Camptotheca, poria cocos and astragalus membranacaus.

This disclosure concerns nucleic acid molecules and methods of use thereof for control of insect pests through RNA interference-mediated inhibition of target coding and transcribed non-coding sequences in insect pests, including coleopteran and/or hemipteran pests. The disclosure also concerns methods for making transgenic plants that express nucleic acid molecules useful for the control of insect pests, and the plant cells and plants obtained thereby.

The disclosure relates to isolated microorganisms-including novel strains of the microorganisms-microbial consortia, and agricultural compositions comprising the same. Furthermore, the disclosure teaches methods of utilizing the described microorganisms, microbial consortia, and agricultural compositions comprising the same, in methods for imparting beneficial properties to target plant species. In particular aspects, the disclosure provides methods of increasing desirable plant traits in agronomically important crop species.

Resumen de: US2017261495A1

The presently disclosed subject matter relates to the generation of induced pluripotent stem cell (iPSC)-derived neuronal cell lines from subjects diagnosed with polyhydramnios-megalencephaly-symptomatic-epilepsy (PMSE) and assays making use of such cell lines to identify mammalian target of rapamycin (mTOR) signalling modulators as well as anti-epileptogenic compounds.