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Resultados 122 resultados LastUpdate Última actualización: 27/08/2016 [15:57:00] pdf PDF




Solicitudes de Patente publicadas en los últimos 30 días / Patent Applications last 30 days publications



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Hydrogel compositions, methods for preparing the same and uses thereof

Nº publicación: GB2535562A 24/08/2016

Solicitante:
CHONGQING MJ MEDICAL DEVICES CO LTD [CN]

Resumen de: GB2535562A

Disclosed are a hydrogel composition, method for preparing the same and use thereof. The hydrogel composition comprises a guar gum derivative which is crosslinked, a mint-based component, water, and optionally, an amphiphilic core-shell nanoparticle having a hydrophobic core and a hydrophilic shell, wherein the amount of the mint-based component is in the range of 1-6 wt% and the amount of the water is in the range of 65-95 wt%, based on the total weight of the hydrogel composition. The hydrogel composition is safe and can provide symptomatic relief for patients with symptoms such as severe and intractable pruritus associated with hypertrophic scars. The symptomatic relief effect of the hydrogel composition is reproducible, and is independent of the etiology of the burn trauma, extent of the scarring and duration of the scar formation, while tachyphylaxis is not observed. Also disclosed is a medical device comprising the hydrogel composition.



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DEVICE FOR FORMULATING PARTICLES AT SMALL VOLUMES

Nº publicación: EP3057693A1 24/08/2016

Solicitante:
UNIV BRITISH COLUMBIA [CA]

Resumen de: WO2015057998A1

Methods and devices for making particles at small volumes.



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NANOPARTICLE COMPOSITIONS AND METHODS AS CARRIERS OF NUTRACEUTICAL FACTORS ACROSS CELL MEMBRANES AND BIOLOGICAL BARRIERS

Nº publicación: EP3057604A1 24/08/2016

Solicitante:
NANOSPHERE HEALTH SCIENCES LLC [US]

Resumen de: WO2015057751A1

Novel process and products thereby emplace nutraceutical factors within nanodelivery vehicles for various indications in mammals, including humans.



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FORMULATIONS USEFUL IN THE TREATMENT OF PROLIFERATIVE DISEASES AFFECTING THE RESPIRATORY TRACT

Nº publicación: EP3057619A1 24/08/2016

Solicitante:
UNIVERSIT\u00C9 LIBRE DE BRUXELLES [BE]

Resumen de: WO2015055796A1

The present application provides a pharmaceutical formulation comprising a folate receptor (FR)- targeting antineoplastic substance or composition, wherein the pharmaceutical formulation is configured for administration by inhalation,wherein the FR-targeting antineoplastic substance or composition is comprised in a nanoparticle and wherein the nanoparticles are comprised in microparticles,and its use in the treatment of a proliferative disease affecting at least part of the respiratory tract. The present application further provides a pharmaceutical formulation comprising an antineoplastic agent and a FR- targeting excipient, for use in the treatment of a proliferative disease affecting at least part of the respiratory tract.



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NANOPARTICLE-CONTAINING HYDROGELS

Nº publicación: EP3057617A1 24/08/2016

Solicitante:
AGENCY SCIENCE TECH & RES [SG]

Resumen de: WO2015057170A1

There is provided a nanoparticle-containing hydrogel comprising metal nanoparticles and at least one peptide. The nanoparticle-containing hydrogel may possess antibacterial activity. There is also provided a method for preparing the nanoparticle-containing hydrogel, and compositions and uses thereof.



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Synergistically acting amorphous calcium-polyphosphate nanospheres containing encapsulated retinol for therapeutic applications

Nº publicación: GB2535450A 24/08/2016

Solicitante:
WERNER ERNST LUDWIG GEORG MULLER [DE]

Resumen de: GB2535450A

A method for the preparation of degradable amorphous retinoid/calcium-polyphosphate nanospheres comprises: (i) dissolving a retinoid and a calcium salt in an organic solvent; (ii) adding the retinoid calcium salt solution as produced in step (i) to an aqueous solution containing dissolved polyphosphate (polyp) salt and poly(ethylene glycol) or another lubricating coating material, and (iii) collecting washing with water , and drying of the nanospheres as formed. Preferably the retinoid is retinol. Preferably the chain length of the polyphosphate is in the range of about 3 to about 1000 phosphate units. Preferably the amorphous retinoid/calcium-polyphosphate nanospheres are for use in the treatment or prophylaxis of dermatological conditions, such as inflammatory skin disorders, acne, disorders of increased cell turnover such as psoriasis, skin cancers and photoaging. The amorphous retinol/calcium-polyphosphate nanospheres displayed the following: (i) Homogenous size in a range (~45 nm) optimal for cellular uptake by clathrin-mediated endocytosis; (ii) Synergistic effect of both components, retinol and polyphosphate, at non-effective concentrations of the individual components, on cell proliferation and collagen expression (types I, II, and III); (iii) Pronounced synergistic effect on expression of collagen type III; (iv) Disintegration by extracellular enzymatic hydrolysis; (v) Dual biological effect of polyP and retinol, both via the extracellular and via the intracellular r



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MULTIFUNCTIONAL METALLIC NANOSTRUCTURE AND METHOD FOR MANUFACTURING THE SAME

Nº publicación: EP3059589A1 24/08/2016

Solicitantes:
IMRA AMERICA INC [US]
JAPAN FOUND CANCER [JP]

Resumen de: US2015110882A1

It is intended to provide a stable metallic nanostructure that causes no aggregation when surface-modified with biomolecule-reactive functional molecules. 30 to 90% of the surface of a metallic nanostructure is covered with at least one or more types of colloid-stabilizing functional molecules. The remaining portions on the surface of the metallic nanostructure are further covered with one or more types of biologically functional molecules.



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MULTIFUNCTIONAL DEGRADABLE NANOPARTICLES WITH CONTROL OVER SIZE AND FUNCTIONALITIES

Nº publicación: US2016237208A1 18/08/2016

Solicitante:
UNIV VANDERBILT [US]

Resumen de: US2013142733A1

In one aspect, the invention relates to polymers, crosslinked polymers, functionalized polymers, nanoparticles, and functionalized nanoparticles and methods of making and using same. In one aspect, the invention relates to degradable polymers and degradable nanoparticles. In one aspect, the invention relates to methods of preparing degradable nanoparticles and, more specifically, methods of controlling particle size during the preparation of degradable nanoparticles. In one aspect, the degradable nanoparticles are useful for complexing, delivering, and releasing payloads, including pharmaceutically active payloads. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.



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A PROCESS FOR THE PREPARATION OF POLYACRYLOYL HYDRAZIDE STABILIZED METAL NANO PARTICLES AND THE PRODUCTS OBTAINED THEREBY

Nº publicación: WO2016128988A1 18/08/2016

Solicitante:
RAJIV GANDHI INST OF PETROLEUM TECH RAE BARELI [IN]

Resumen de: WO2016128988A1

There is disclosed a process for preparation of polyacryloyl hydrazide stabilized metal nano particles such as PAH stabilized silver or gold nano particles comprising reacting aqueous solution of a homo or co-polymer of acryloyl hydrazide (PAH) with corresponding metal salt solution in ambient conditions. There is further disclosed an one pot process for preparation of drug loaded polyacryloyl hydrazide stabilized metal such as silver or gold nano particles. The invention also discloses such polyacryloyl hydrazide stabilized metal nano particles as well as its drug loaded and sustained release formulation.



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AMORPHOUS MAGNESIUM-SUBSTITUTED CALCIUM PHOSPHATE COMPOSITIONS AND THEIR USES

Nº publicación: US2016235683A1 18/08/2016

Solicitante:
MEDICAL RES COUNCIL [GB]

Resumen de: WO2015067939A1

Amorphous magnesium-substituted calcium, phosphate compositions and their medical uses are described, in particular for use in delivering cargo materials, such as cargo molecules or cargo nanoparticles contained in pores of the amorphous magnesium- substituted calcium phosphate to cells of the immune system, fo example as therapeutic approaches for the treatment of inflammatory bowel diseases, and in particular Crohn's disease, autoimmune diseases, allergy and for therapeutic vaccination.



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ANTI-BACTERIAL APPLICATIONS OF POLY -N-ACETYLGLUCOSAMINE NANOFIBERS

Nº publicación: US2016235774A1 18/08/2016

Solicitante:
MARINE POLYMER TECH INC [US]

Resumen de: WO2011130646A1

Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof ("sNAG nanofibers") and anti-bacterial applications of such compositions. The sNAG nanofibers may be formulated into compositions for the prevention and/or treatment of bacterial infections and diseases associated with such infections. Regimens employing such compositions are also described.



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MICRO-PARTICULATED NANOCAPSULES CONTAINING LOPINAVIR WITH ENHANCED ORAL BIOAVAILABILITY AND EFFICACY

Nº publicación: US2016235749A1 18/08/2016

Solicitante:
YISSUM RES DEV COMPANY OF THE HEBREW UNIV OF JERUSALEM LTD [IL]

Resumen de: US2016235749A1

The present disclosure provides controlled-release delivery systems for oral delivery of active agents, e.g. lopinavir, comprising micro-particulated with enhanced oral bioavailability and efficacy, which may be used for treating HIV.



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DUALLY DERIVATIZED CHITOSAN NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME FOR GENE TRANSFER IN VIVO

Nº publicación: US2016235863A1 18/08/2016

Solicitante:
ENGENE INC [CA]

Resumen de: WO2015042711A1

Provided herein is chitosan-derivative nanoparticle comprising chitosan functionalized with a cationic amino acid and a hydrophilic polyol; and methods of making and using same, e.g., for gene delivery in vivo.



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CANCER TREATMENTS

Nº publicación: US2016235860A1 18/08/2016

Solicitante:
MAYO FOUND FOR MEDICAL EDUCATION AND RES [US]

Resumen de: WO2014055415A1

This document provides methods and materials related to treating cancer (e.g., skin cancer). For example, methods and materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., ABRAXANE®/anti-VEGF polypeptide antibody complexes) to treat cancer (e.g., skin cancer) are provided.



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PROCESS FOR PREPARING WATER DISPERSIONS CONTAINING HIGH CONCENTRATION OF NANO/SUBMICRON, HYDROPHOBIC, FUNCTIONAL COMPOUNDS AND WATER DISPERSIONS OBTAINABLE THEREFROM

Nº publicación: US2016235669A1 18/08/2016

Solicitante:
FOOD IND RES AND DEV INST [TW]

Resumen de: US2016235669A1

The present invention provides a process for preparing a water dispersion containing a high concentration of nano/submicron, hydrophobic, functional compounds. The process is carried out by using a complex stabilizer having an HLB value of about 10 to about 17, comprising lecithin and at least one non-phospholipid selected from polysorbate, sucrose ester, and polyglycerol fatty acid ester; selecting a specific weight ratio of the hydrophobic functional compounds and the stabilizer; and using homogenization technique, media milling technique, and/or centrifugal technique. The water dispersion containing a high concentration of nano/submicron, hydrophobic, functional compound produced by the process of the invention has stable dispersibility and improved bioavailability, and can be applied to the fields of foods and pharmaceuticals.



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SUGAR ESTER NANOPARTICLE STABILIZERS

Nº publicación: US2016235687A1 18/08/2016

Solicitante:
ST JOHN'S UNIV [US]

Resumen de: US2016235687A1

Solid dosage forms containing nanoparticles are prepared where sugar esters serve as nanoparticle stabilizers that prevent agglomeration of nanoparticles during preparation of the solid dosage form and allow for restoration of the original nanoparticle size of the nanoparticles upon redispersion of the solid dosage form in aqueous media.



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MULTICOMPONENT, INTERNALLY STRUCTURED NANOEMULSIONS AND METHODS OF PRODUCTION

Nº publicación: US2016235670A1 18/08/2016

Solicitante:
THE REGENTS OF THE UNIV OF CALIFORNIA [US]

Resumen de: WO2015051179A1

The present invention is directed to emulsions with a plurality of droplets dispersed in a continuous liquid medium. These droplets can contain at least a first droplet liquid and a second droplet liquid and can have an ensemble-average maximal spatial dimension that is less than 1 micrometer. The invention includes preparation, uses and compositions containing emulsions. Solute materials can also be dissolved in the droplet liquids.



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FORMULATIONS INCLUDING SILVER NANOPARTICLES AND METHODS OF USING THE SAME

Nº publicación: US2016235635A1 18/08/2016

Solicitante:
UNIV OF SOUTH ALABAMA [US]

Resumen de: WO2015057983A1

A method for reducing or inhibiting damage to skin is disclosed herein. In some embodiments, the damage is ultraviolet (UV) radiation-induced damage. In some embodiments, the method comprises applying to the skin prior to exposure to radiation damaging source, a formulation containing an effective amount of silver nanoparticles (AgNPs) A method for treating damaged skin, and formulations include AgNPs are also disclosed.



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AMORPHOUS NANOPARTICLES PREPARED BY ELECTROSPRAYING

Nº publicación: US2016235677A1 18/08/2016

Solicitante:
NANOCOPOEIA LLC [US]

Resumen de: WO2016086193A1

A method of converting a poorly water soluble crystalline compound to an amorphous compound and a method of increasing the solubility of a poorly water soluble crystalline compound in biore levant fluid at pH 6.5 is disclosed. The method includes dissolving the compound and a polymer in a solvent to form a solution, the polymer being present in the solution in an amount such that after electrospraying the solution the compound is in an amorphous form, electrospraying the solution using an electrospray system, the electrospraying forming nanoparticles, collecting the nanoparticles on a substrate, and removing the nanoparticles in the form of a powder.



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DEVICE FOR FORMULATING PARTICLES AT SMALL VOLUMES

Nº publicación: US2016235688A1 18/08/2016

Solicitantes:
WALSH COLIN [US]
THE UNIV OF BRITISH COLUMBIA [CA]

Resumen de: WO2015057998A1

Methods and devices for making particles at small volumes.



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METHODS OF TREATING LUNG CANCER

Nº publicación: AU2016208354A1 18/08/2016

Solicitante:
ABRAXIS BIOSCIENCE LLC

Resumen de: AU2013203373A1

The present invention provides methods and compositions for treating non-small-cell lung cancer (NSCLC) by administering a) a composition comprising nanoparticles that comprise paclitaxel and an albumin and b) a platinum-based agent (e.g., carboplatin), wherein the individual has diabetes, has four or more metastatic sites, and/or is at least about 70 years old.



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MANUFACTURING METHOD FOR STABILIZED RETINOL EMULSION COMPOSITIONS USING CATECHIN

Nº publicación: WO2016129739A1 18/08/2016

Solicitante:
BIOGENICS INC [KR]

Resumen de: KR101547611B1

The present invention relates to a method for manufacturing stabilized retinol emulsion using catechin (EGCG), which encapsulates retinol into micelles of nano or micro emulsion using the catechin as a stabilizing agent to stabilize unstable retinol. The present invention comprises the steps of: forming emulsion with an amphiphilic block copolymer which can form nano- or mircro- emulsion; encapsulating the retinol into micelles; and encapsulating the catechin into the micelles with the stabilizing agent to uniformly mix the catechin with the retinol, whereas the retinol emulsion contains 0. 5-50 wt% of the amphiphilic block copolymer; 0.1-15 wt% of the retinol; 0.1-10 wt% of the catechin (EGCG); and a remainder of water, a hydrophilic solvent or their mixture.



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COMPOSITIONS AND METHODS OF TUMOR TREATMENT UTILIZING NANOPARTICLES

Nº publicación: WO2016131006A1 18/08/2016

Solicitantes:
ORIENT PHARMA INC [US]
TRENDMED CO LTD [CN]

Resumen de: WO2016131006A1

The present invention is directed to a method for treating cancer intraperitoneally in a subject. The method comprises administering to said subject in need thereof an anti-cancer agent encapsulated in nanoparticles wherein nanoparticles are characterized to slowly release anticancer agent in a timely fashion that allows efficient killing of tumor cells. The nanoparticles described herein are characterized to slowly release anti-cancer agent at a rate of 30% or less per 8 hours based on dialysis.



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CYCLIC CARBONATE MONOMER CONTAINING DOUBLE IODINE, BIODEGRADABLE POLYMER PREPARED THEREBY AND USE

Nº publicación: WO2016127940A1 18/08/2016

Solicitante:
SOOCHOW UNIV [CN]

Resumen de: WO2016127940A1

Disclosed are a cyclic carbonate monomer containing double iodine, a biodegradable polymer prepared thereby and a use. The polymer can be obtained by ring-opening polymerization of the cyclic carbonate monomer containing double iodine, without affecting the ring-opening polymerization and without a protection and deprotection process. The polymer which is obtained by ring-opening polymerization of the cyclic carbonate monomer of the present invention can be assembled into a nano-vesicle and a micelle as a drug carrier, a biological tissue scaffold or a CT contrast media.



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Medicinal nano silver paste and preparation method thereof

Nº publicación: WO2016127724A1 18/08/2016

Solicitante:
CHANGSHA DIGU NANO BIOTECHNOLOGY CO LTD [CN]

Resumen de: CN104721227A

The invention discloses a formula and preparation method of high-purity medicinal nano silver paste. According to the formula and preparation method of the high-purity medicinal nano silver paste, specific high-purity spherical ultrafine nano silver powder and the medicinal nano silver paste are selected. According to the indexes of the specific high-purity spherical ultrafine nano silver powder, the silver purity is larger than or equal to 99.99 percent, the silver shape is spherical, and the silver particle size ranges from 0.1 nm to 10 nm. According to the formula of the medicinal nano silver paste, the medicinal nano silver paste comprises 1 g/L to 2 g/L glucose, 1 g/L to 2 g/L nano-silver, 996 g/L to 998 g/L pure water. The preparation method of the medicinal nano silver paste comprises dispersing, stirring, atomizing, collecting and liquid taking.


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