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Resultados 136 resultados LastUpdate Última actualización 24/11/2017 [15:26:00] pdf PDF




Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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METHODS FOR TREATING TAUOPATHY

NºPublicación: EP3244914A1 22/11/2017

Solicitante:
THE J DAVID GLADSTONE INST [US]

Resumen de: WO2016115520A1

The present disclosure provides methods of reducing the level of acetylated Tau in a neuron or a glial cell in an individual, the methods involving administering to the individual a prodrug that is converted in the individual to salicylate. The present disclosure provides methods of treating a tauopathy in an individual, the methods involving administering to the individual a prodrug that is converted in the individual to salicylate.



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BI-FUNCTIONAL CO-POLYMER USE FOR OPHTHALMIC AND OTHER TOPICAL AND LOCAL APPLICATIONS

NºPublicación: EP3246048A1 22/11/2017

Solicitante:
EYEON PARTICLE SCIENCES LLC [US]

Resumen de: EP3246048A1

A composition comprising a copolymer having a positively charged, or hydrophobic or covalent bonding moiety and a hydrophilic moiety, for use in a method for prolonging the stability of ocular surface tear film in a subject; wherein said method comprises contacting the surface of the eye with said composition in an amount and for a duration so as to prolong the stability of ocular surface tear film in that subject.



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NEUTRON CAPTURE THERAPY COMPOSITION FORMED USING ION IMPLANTATION

NºPublicación: CN107362359A 21/11/2017

Resumen de: WO2017193723A1

Provided are a neutron capture therapy composition (200) and a manufacturing method of the composition (200). The composition (200) comprises at least one nanodiamond (210) and at least one neutron-capture element (220). The at least one neutron-capture element (220) is embedded, by means of an ion implantation system, into the at least one nanodiamond (210).



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METHOD FOR TREATING PANCREATIC CANCER BASED ON GOLD NANOCLUSTER IN COMBINATION WITH NGF SIRNA

NºPublicación: CN107362370A 21/11/2017

Resumen de: WO2017193460A1

Disclosed are a combination of NGF siRNAs with gold nanoclusters and a preparation method therefor, a pharmaceutical composition and a kit comprising the combination of NGF siRNAs with gold nanoclusters, and the use of the combination of NGF siRNAs with gold nanoclusters in the preparation of drugs for preventing and/or treating cancers. The combination of NGF siRNAs with gold nanoclusters comprises gold nanoclusters and NGF siRNAs, and the gold nanoclusters are combined with the NGF siRNAs via electrostatic adsorption.



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pH敏感智能型纳米药物载体的制备方法

NºPublicación: CN107349188A 17/11/2017

Resumen de: CN107349188A

本发明主要涉及肿瘤研究和治疗的高分子材料领域,具体是关于种基于聚组氨酸构型变化的三嵌段聚合物pH敏感智能型纳米药物载体的制备方法。制备出载多西紫杉醇的智能型pH敏感纳米载体TPGS‑PHis‑Folate。载体冠层中引入聚乙二醇,实现在体内血液中长循环的功能;将pH敏感材料聚(L‑组氨酸)引入纳米载体结构中,使载体在不同pH下实现智能化变化:即在正常生理pH下,靶向分子叶酸将隐蔽于载体聚乙二醇冠层,关闭载体主动靶向功能;而在弱酸肿瘤组织,聚(L‑组氨酸)发生质子化,其水溶性变强,隐蔽在聚乙二醇冠层下的靶向分子叶酸伸张出来,并暴露于载体的最外端,其主动靶向功能打开;载体再以叶酸受体介导的内吞途径易进入细胞;在酸性内涵体/溶酶体环境下,聚(L‑组氨酸)开始逐渐解离,使药物在胞内快速释放。



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种PLGA复合微球材料的制备方法

NºPublicación: CN107353418A 17/11/2017

Resumen de: CN107353418A

本发明涉及聚合物微球的制备工艺,特别是种PLGA复合微球材料的制备方法,步骤包括,步骤,取PLGA粉末与特定制剂M纳米颗粒,混合,并加入二氯甲烷中,制得PLGA‑M二氯甲烷溶液,取聚乙烯醇溶解于水中,制得聚乙烯醇水溶液;步骤二,将步骤制得的PLGA‑M二氯甲烷溶液与聚乙烯醇水溶液以不同的速率混合制得PLGA‑M乳液,然后静置,得到PLGA‑M复合液滴;步骤三,在步骤二得到的PLGA‑M复合液滴中加入聚乙烯醇的水溶液,静置,之后低温干燥,得到PLGA‑M复合微球。本技术方案可制得大小可控并均匀的PLGA‑M复合微球。



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藏药十味甘露微丸制剂及其制备工艺

NºPublicación: CN107349295A 17/11/2017

Resumen de: CN107349295A

本发明公开了种藏药十味甘露微丸制剂,包括原料和辅料,所述,原料包括以下组分:木香、沉香、藏木香、广枣、乳香、甘青青兰、去壳诃子、木棉花、肉豆蔻、石灰华和寒水石,所述辅料为粘合剂和填充剂中的任意种或两种;其制备工艺包括以下步骤:S1:挥发油的提取;S2:植物药中有效成分的提取;S3:矿物药粉的制备;S4:将矿物药粉与植物药提取液混合均匀,并经浓缩和喷雾干燥制备成细粉,再挥发油粉末加入湿法制粒机中进行混合,混合均匀后加入辅料制成软材,再制备成微丸。本发明提出的微丸制剂,药效可靠、服用剂量准确、质量稳定、成本低,治疗效果好,生产工艺精细,重现性好,质量可控性好,工业化生产效率高,适用范围广。



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种负载索拉菲尼/siRNA的介孔二氧化硅‑乳糖醛酸靶向纳米颗粒

NºPublicación: CN107349432A 17/11/2017

Resumen de: CN107349432A

本发明公开了种负载索拉菲尼/siRNA的介孔二氧化硅‑乳糖醛酸靶向纳米颗粒及其在制备抗癌治疗药物上的应用。所述靶向纳米颗粒是将介孔二氧化硅纳米颗粒经表面氨基化修饰后,将索拉菲尼负载在其内孔道中,将乳糖醛酸共价偶联到其外表面上,并通过静电吸附作用,将siRNA吸附到其外表面而构成。本发明这载药体系不仅可提高siRNA的稳定性,还可实现索拉菲尼的靶向给药,从而有效减轻其对正常细胞的毒副作用。



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POLY(AMINE-CO-ESTER) NANOPARTICLES AND METHODS OF USE THEREOF

NºPublicación: WO2017197128A1 16/11/2017

Solicitante:
UNIV YALE [US]

Resumen de: WO2017197128A1

Polymers including poly(amine-co-ester), poly(amine-co-amide), or a combination thereof, and nanoparticles, particularly solid core nanoparticles, formed therefrom are provided. Solid core nanoparticles fabricated from hydrophobic polymers often require the presence of cationic complexing agents to stabilize negatively charged active agents such as siRNA. However, complexing agents are optional in the disclosed formulations because the nanoparticles contain cationic amines to stabilize negatively charged nucleic acids and hydrophobic domains to condense the nucleic acid into the core of the formed nanoparticles, thus improving encapsulation efficiency. This increase in nucleic acid loading allows the disclosed solid core nanoparticles to deliver more nucleic acid per cell without increasing total polymer delivered, further reducing cytotoxicity. Pharmaceutical compositions including an effective amount of the nanoparticles are also provided, and be used, for example, for in vitro and in vivo delivery of nucleic acids.



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PREPARATION METHOD FOR FUNCTIONAL BIODEGRADABLE NANO-PARTICLES BASED ON POLYAMINO ACID

NºPublicación: WO2017193294A1 16/11/2017

Solicitante:
ZHANGJIAGANG INSTITUTE OF INDUSTRIAL TECHNOLOGIES SOOCHOW UNIV [CN]

Resumen de: WO2017193294A1

Disclosed is a preparation method for nano-particles based on a polyamino acid. Firstly, a hydrophobic hydroxy compound and p-nitrophenylchloroformate are used as raw materials, and reacted to obtain functional hydrophobic small molecules activated by the p-nitrophenylchloroformate; then the functional hydrophobic small molecules activated by p-nitrophenylchloroformate and a diamine compound are used as reactants, and reacted to prepare a hydrophobic amido compound; then, the hydrophobic amido compound is used as an initiator, and ring opening polymerization is performed on α-amino acid-N-carboxyl anhydride compound to obtain a polymer based on polyamino acid; and finally the polymer based on polyamino acid is dissolved in water, then an acetone solution of the polymer is added, and stirred to obtain the functional biodegradable nano-particles based on polyamino acid. The obtained drug-loading targeted nano-particles have a very high stability, can be combined with targeting molecules so as to be well enriched at a tumor site, and have a good therapeutical effect and low toxic and side effects on various solid tumors, including human breast cancer.



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MICRO- AND NANO-PARTICLES WITH VARIABLE SURFACE MORPHOLOGIES AND METHODS OF MAKING SAME

NºPublicación: US2017326523A1 16/11/2017

Solicitante:
MASSACHUSETTS UNIV OF [US]

Resumen de: US2017326523A1

According to various aspects and embodiments, multilayer particles having an irregular surface architecture and methods of making the same are disclosed.



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Advanced functional biocompatible polymeric matrix containing nano-compartments

NºPublicación: US2017326169A1 16/11/2017

Solicitante:
UNIV OF MARYLAND COLLEGE PARK [US]

Resumen de: US2017326169A1

The present invention provides a novel biomaterial which is a hybrid, self-assembling biopolymeric networked film that is functionalized through hydrophobic interactions with vesicles loaded with bioactive agents. The biomaterial compound is a polymeric network of hydrophobically modified chitosan scaffolds that is taken from solution and formed as a solid film. This solid state film is capable of hydrophobic interactions with the functionalized vesicles. The vesicles include one or more lamellar structures forming one or more nano-compartments that are capable of containing similar or alternative active moieties within. Use of the film results in a degradation of the chitosan scaffold thereby releasing the active moieties within the vesicles from the scaffold. Application of the current invention occurs through various delivery mechanisms and routes of administration as will be described herein.



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COMBINATION THERAPIES

NºPublicación: US2017326234A1 16/11/2017

Solicitante:
CELGENE CORP [US]

Resumen de: US2017326234A1

The present invention provides combination therapy methods of treating a proliferative disease (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include the administration of an effective amount of at least one other agent that antagonizes a PD-1 pathway in a cell.



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LIPID NANOPARTICLES COMPRISING LIPOPHILIC ANTI-INFLAMMATORY AGENTS AND METHODS OF USE THEREOF

NºPublicación: WO2017194454A1 16/11/2017

Solicitante:
ASTRAZENECA AB [SE]

Resumen de: WO2017194454A1

Disclosed herein are lipid nanoparticles comprising a lipid phase and at least one lipophilic anti-inflammatory agent, and pharmaceutical compositions comprising lipid nanoparticles and methods for using lipid nanoparticles.



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PH-SENSITIVE PEPTIDES AND THEIR NANOPARTICLES FOR DRUG DELIVERY

NºPublicación: US2017326253A1 16/11/2017

Solicitante:
THE TRUSTEES OF THE UNIV OF PENNSYLVANIA [US]

Resumen de: US2017326253A1

A new nanoscale carrier made by one or more pH-sensitive peptides is provided for delivery of a biologically active substance. The peptides are composed of pH-sensitive hydrophilic and hydrophobic amino acids in the backbone. As the pH environment changes from physiological pH level to a weakly acidic environment such as near a tumor site (pH.about.6.5-6.9), the peptides may dissolve, releasing the biological substance. Also provided are the delivery methods and related kits.



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ARTIFICIAL BACTERIOPHAGE BASED ON CARBON NANOSTRUCTURES FOR SUPPLYING MEDICAMENTS

NºPublicación: US2017326239A1 16/11/2017

Solicitante:
UNIV DEL VALLE [CO]

Resumen de: US2017326239A1

The invention relates to an artificial bacteriophage for supplying medicaments, nutrients, proteins, DNA/RNA or other type of molecules to bacteria and/or diseased cells, directly to the cytoplasm, passing through the cell membrane thereof, through a pore of said membrane. The artificial bacteriophage is based on carbon nanostructures and comprises a nanocontainer for medicaments, a channel for transporting medicaments and a tip together with an array of linker proteins and protein receptors.



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ION IMPLANTATION OF NEUTRON CAPTURE ELEMENTS INTO NANODIAMOND PARTICLES TO FORM COMPOSITION FOR NEUTRON CAPTURE THERAPY USAGE

NºPublicación: US2017326236A1 16/11/2017

Solicitante:
NIU HUAN [TW]
CHEN CHIEN HSU [TW]
JEN CAUSON KO-CHUAN [US]

Resumen de: US2017326236A1

A composition for neutron capture therapy and a method of preparing the same are provided. The composition includes at least one nanodiamond particle and at least one neutron capture element, in which the at least one neutron capture element is embedded into the at least one nanodiamond particle by using an ion implantation system.



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JANUS NANOPARTICLE AND METHOD FOR PRODUCING THE SAME

NºPublicación: US2017326073A1 16/11/2017

Solicitante:
CBC CO LTD [JP]
MASAHIRO MURAKAMI [JP]

Resumen de: US2017326073A1

It is an object of the present invention to provide a Janus nanoparticle, into which a drug can be encapsulated by a simple method, and a method for producing the same. According to the present invention, provided is a method for producing a Janus nanoparticle having a particle diameter of 0.01 to 5000 μm, which is composed of a lipid and a polymer, wherein the method comprises: a step of emulsifying a solution of one or more types of lipids and one or more types of polymers dissolved in a common solvent in an aqueous solution of a surfactant(s); and a step of removing the common solvent from the obtained emulsion.



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YEAST CELL WALL PARTICLES FOR RECEPTOR-TARGETED NANOPARTICLE DELIVERY

NºPublicación: US2017326071A1 16/11/2017

Solicitante:
UNIV OF MASSACHUSETTS [US]

Resumen de: US2017326071A1

The present invention generally relates to yeast cell wall microparticles loaded with nanoparticles for receptor-targeted nanoparticle delivery. In particular, the present invention relates to trapping nanoparticles either on the surface or inside a yeast glucan particles, for example, yeast glucal particles. The present invention further relates to methods of making the yeast cell wall particles loaded with nanoparticles. The present invention also relates to methods of using the yeast cell wall particles particles loaded with nanoparticles for receptor-targeted delivery of the nanoparticles, e.g., drug containing nanoparticles.



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Nanoparticles for Delivery of Agents to Glioblastoma Tumors

NºPublicación: US2017326252A1 16/11/2017

Solicitante:
NANOFORMA INC [US]

Resumen de: US2017326252A1

The present invention is, in general, directed to nanoparticles for the delivery of agents to glioblastoma tumors. More particularly, the present invention relates to nanoparticle conjugates that deliver and release agents to a glioblastoma tumor. The invention is also directed to methods of delivering agents to glioblastoma tumors.



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GREEN SYNTHESIS OF REDUCED GRAPHENE OXIDE SILICA NANOCOMPOSITE USING NIGELLA SATIVA SEEDS EXTRACT

NºPublicación: US2017326097A1 16/11/2017

Solicitante:
KING SAUD UNIV [SA]

Resumen de: US2017326097A1

The green synthesis of a reduced graphene oxide (rGO) silica (SiO2) nanocomposite using Nigella sativa seed extract includes mixing a quantity of carbon source in an acid solution while stirring to obtain a solution; adding a first oxidant gradually into said solution to oxidize the soot and obtain a first suspension; stirring the first suspension while maintaining a temperature of said suspension to about 35° C.; adding plant seeds extract to the first suspension while raising the temperature of the suspension to about 60° C.; adding a second oxidant to said suspension to form the reduced graphene oxide nanoparticles; isolating the reduced graphene oxide nanoparticles by centrifugation; suspending the reduced graphene oxide nanoparticles in water; adding a solution comprising tetraethyl orthosilicate (TEOS), concentrated aqueous ammonia solution and a plant seeds extract under ultrasonication; and increasing the temperature to about 90° C. to form reduced graphene oxide-silicon dioxide nanocomposite suspension.



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NANOPARTICLES FOR ENCAPSULATING COMPOUNDS, THE PREPARATION AND USES THEREOF

NºPublicación: US2017326074A1 16/11/2017

Solicitante:
INNOUP FARMA S L [ES]

Resumen de: US2017326074A1

The present invention relates to nanoparticles for encapsulating biologically active compounds, comprising a matrix of new polymer conjugates. The invention also relates to a process for producing both the conjugates and nanoparticles, to compositions containing said conjugates or nanoparticles, and applications thereof. The invention is applicable in the pharmaceutical sector and in the nanotechnology sector.



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NEUTRON CAPTURE THERAPY COMPOSITION FORMED USING ION IMPLANTATION

NºPublicación: WO2017193723A1 16/11/2017

Solicitante:
NIU HUAN [CN]
CHEN CHIEN-HSU [CN]
JEN CAUSON KO-CHUAN [US]

Resumen de: WO2017193723A1

Provided are a neutron capture therapy composition (200) and a manufacturing method of the composition (200). The composition (200) comprises at least one nanodiamond (210) and at least one neutron-capture element (220). The at least one neutron-capture element (220) is embedded, by means of an ion implantation system, into the at least one nanodiamond (210).



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PACLITAXEL PALMITATE LIPOSOME AND PREPARATION METHOD THEREOF

NºPublicación: WO2017193823A1 16/11/2017

Solicitante:
SHANGHAI TIAN SHI LI PHARMACEUTICAL SCIENCE AND TECH CO LTD [CN]

Resumen de: WO2017193823A1

The present invention relates to the technical field of pharmaceuticals, and specifically relates to a paclitaxel palmitate liposome and preparation method thereof. The paclitaxel palmitate is obtained by an esterification of a 2' hydroxy group of paclitaxel with palmitic acid, and is regarded as a paclitaxel prodrug. The prodrug can be used to address an issue of poor fat solubility of paclitaxel and poor pharmaceutical manufacturability of a nano-scale formulation of the paclitaxel. The invention performed, according to unique physical and chemical properties of the paclitaxel palmitate, a compatibility study for a composition and preparation technique of a formulation. The paclitaxel palmitate liposome provided by the invention does not contain polyethoxylated castor oil, is safe and reliable, and can be prepared using simple techniques.



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METHOD FOR TREATING PANCREATIC CANCER BASED ON GOLD NANOCLUSTER IN COMBINATION WITH NGF SIRNA

Nº publicación: WO2017193460A1 16/11/2017

Solicitante:
NATIONAL CENTER FOR NANOSCIENCE AND TECH [CN]

Resumen de: WO2017193460A1

Disclosed are a combination of NGF siRNAs with gold nanoclusters and a preparation method therefor, a pharmaceutical composition and a kit comprising the combination of NGF siRNAs with gold nanoclusters, and the use of the combination of NGF siRNAs with gold nanoclusters in the preparation of drugs for preventing and/or treating cancers. The combination of NGF siRNAs with gold nanoclusters comprises gold nanoclusters and NGF siRNAs, and the gold nanoclusters are combined with the NGF siRNAs via electrostatic adsorption.


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