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Resultados 114 resultados LastUpdate Última actualización: 25/09/2016 [16:14:00] pdf PDF




Solicitudes de Patente publicadas en los últimos 30 días / Patent Applications last 30 days publications



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NANOPARTICLES COMPRISING A STABILIZED BORONIC ACID COMPOUND

Nº publicación: WO2016146516A1 22/09/2016

Solicitante:
LEON-NANODRUGS GMBH [DE]

Resumen de: WO2016146516A1

The present invention provides nanoparticles comprising at least one boronic acid compound and at least one stabilizing agent for the at least one boronic acid compound and/or a reaction product of the at least one boronic acid compound and the at least one stabilizing agent, whereby the nanoparticles have a particle size of about 10 to about 1000 nm. The present invention also provides a pharmaceutical composition comprising these nanoparticles and a method for the preparation of these nanoparticlesand the respective pharmaceutical compositions.In addition, the present invention provides nanoparticles and pharmaceutical compositions for the treatment of several disorders, especially multiple myeloma, preferably by parenteral administration.



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PHARMACEUTICAL COMPOSITIONS OF CAROTENOID

Nº publicación: US2016271076A1 22/09/2016

Solicitante:
HEALTH-EVER BIOTECH CO LTD [TW]

Resumen de: WO2015087242A1

The present invention provides pharmaceutical compositions comprising a chylomicron and a carotenoid. The present invention also provides pharmaceutical compositions comprising a micelle and a carotenoid, suspended in an aqueous solution and suitable for intravenous administration. The bioavailability of the carotenoid of the pharmaceutical composition is higher relative to the bioavailability of free carotenoid.



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TARGET SPECIFIC COMPOSITION FOR PHOTOTHERMAL THERAPY

Nº publicación: WO2016148402A1 22/09/2016

Solicitante:
GACHON UNIV OF INDUSTRY-ACADEMIC COOP FOUNDATION) [KR]

Resumen de: KR101556144B1

The present invention relates to a target specific composition for a photothermal therapy and a photothermal therapy method using the composition and, more specifically, to a photothermal therapy method for selectively killing an inflammatory cell by using a target specific composition for a photothermal therapy including a dextran-coated carbon nanotube. According to the present invention, the composition for a photothermal therapy including a dextran-coated carbon nanotube is absorbed only in an inflammatory cell, which is a wanted target cell, to cause a photothermal therapeutic reaction by a light radiated from an external light source, and does not damage cells except for the inflammatory cell. The photothermal therapy method using the composition for photothermal therapy minimizes side effects, and maximizes a therapeutic effect.



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COMPOSITIONS AND METHODS FOR SENSITIZING CELLS TO TRAIL-INDUCED APOPTOSIS

Nº publicación: WO2016149264A1 22/09/2016

Solicitante:
THE JOHNS HOPKINS UNIV [US]

Resumen de: WO2016149264A1

The present invention comprises pegylated TRAIL peptides and their use in conjunction with various TRAIL sensitizing agents in tumor homing nanoparticle formulations for use in the treatment of cancer in a subject.



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COMPOSITIONS AND METHODS FOR THE PREVENTION AND TREATMENT OF AUTOIMMUNE CONDITIONS

Nº publicación: US2016271237A1 22/09/2016

Solicitante:
UTI LIMITED PARTNERSHIP [CA]

Resumen de: WO2008109852A2

The methods include selectively reducing or expanding T cells according to the antigenic specificity of the T cells. Therefore, the present invention can be used to reduce or eliminate pathogenic T cells that recognize autoantigens, such as beta cell specific T cells. As such, the present invention can be used to prevent, treat or ameliorate autoimmune diseases such as IDDM. Furthermore, the present invention can be used to expand desirable T cells, such as anti-pathogenic T cells to prevent, treat and/or ameliorate autoimmune diseases.



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HYDROGEL FORMULATION FOR DERMAL AND OCULAR DELIVERY

Nº publicación: US2016271151A1 22/09/2016

Solicitante:
RUTGERS THE STATE UNIV OF NEW JERSEY [US]

Resumen de: US2016271151A1

Formulations of cross-linkable polymers, capable of forming non-toxic and biocompatible hydrogels in situ, containing at least one of doxycycline or minocycline. Methods of using the hydrogels for treating the skin or ocular tissues of mammals exposed to vesicant compounds such as sulfur mustard (SM), nitrogen mustard (NM) or half mustard (2-chloroethyl ethyl sulfide (CEES)) are also disclosed.



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DRYING TECHNIQUES FOR MICROFLUIDIC AND OTHER SYSTEMS

Nº publicación: US2016271513A1 22/09/2016

Solicitante:
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]

Resumen de: WO2015066115A1

The present invention generally relates to microfluidics, and to spray drying and other drying techniques. Various embodiments of the invention are generally directed to systems and methods for drying fluids contained within a channel such as a microfluidic channel. For example, a fluid may be partially or completely dried within a microfluidic channel, prior to being sprayed into a collection region. In some embodiments, the fluids may be dried relatively rapidly, resulting in spray-dried particles that are partially or completely amorphous. For instance, the fluid may contain salts, drugs, small molecules, ceramics, inorganic species, metals, sugars, polymers, etc., which may be dried to form partially or completely amorphous nanoparticles containing these species.



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NUCLEIC ACID NANOSTRUCTURES FOR IN VIVO AGENT DELIVERY

Nº publicación: US2016271268A1 22/09/2016

Solicitante:
DANA-FARBER CANCER INST INC [US]

Resumen de: WO2015070080A2

The present disclosure provides, in some aspects, nucleic acid nanostructures subsaturated with polyamine polymers. The present disclosure also provides, in some aspects, nucleic acid nanocapsules that include a first nucleic acid nanostructure bound to a second nucleic acid nanostructure through a pH-sensitive interface, thereby forming a nanocapsule having an exterior surface and an interior compartment having an interior surface.



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PEPTIDIC NANODELIVERY COMPOSITION TARGETING TWO RECEPTORS

Nº publicación: US2016271269A1 22/09/2016

Solicitantes:
MOGHIMI SEYED MOIEN [DK]
WU LINPING [DK]
AHMADVAND DAVOUD [DK]
HAMIFARR LADAN [DK]
ANDRESEN THOMAS LARS [DK]

Resumen de: WO2015024931A1

A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor (TFRC) and/or receptor for advanced glycation end products (RAGE). The polypeptide conjugate may be used in a method for targeting of a drug delivery system or diagnostic delivery system.



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CROSS-LINKED POLYMER MODIFIED NANOPARTICLES

Nº publicación: WO2016149378A1 22/09/2016

Solicitantes:
PDX PHARMACEUTICALS LLC [US]
OREGON HEALTH & SCIENCE UNIV [US]

Resumen de: WO2016149378A1

Disclosed herein are nanoconstructs comprising a nanoparticle, coated with additional agents such as cationic polymers, stabilizers, targeting molecules, labels, oligonucleotides and small molecules. These constructs may be used to deliver compounds to treat solid tumors and to diagnose cancer and other diseases. Further disclosed are methods of making such compounds and use of such compounds to treat or diagnose human disease.



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NANOPARTICLE-CONTAINING HYDROGELS

Nº publicación: US2016271178A1 22/09/2016

Solicitante:
AGENCY FOR SCIENCE TECH AND RES [SG]

Resumen de: WO2015057170A1

There is provided a nanoparticle-containing hydrogel comprising metal nanoparticles and at least one peptide. The nanoparticle-containing hydrogel may possess antibacterial activity. There is also provided a method for preparing the nanoparticle-containing hydrogel, and compositions and uses thereof.



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NANOSTRUCTURE CONJUGATES FOR MODULATION OF LOCATION-SPECIFIC SUBTYPES OF RECEPTORS AND ION CHANNELS

Nº publicación: US2016271271A1 22/09/2016

Solicitantes:
MOLOKANOVA ELENA [US]
BRAUN GARY B [US]
SAVTCHENKO ALEX [US]

Resumen de: WO2015069669A1

Nanostructure conjugates, methods for their preparation, and methods for their use are described. The nanostructure conjugates are useful in inhibiting, activating, and modulating extrasynaptic receptors and ion channels, and in treating various medical conditions among other attractive uses.



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NANOPARTICLES AND NANOPARTICLE COMPOSITIONS

Nº publicación: US2016271061A1 22/09/2016

Solicitante:
UNIV IOWA STATE RES FOUND INC [US]

Resumen de: WO2011130114A1

The invention provides multivalent surface-crosslinked micelle (SCM) particles, crosslinked reverse micelle (CRM) particles, and methods of making and using them. The SCM particles can be used, for example, to inhibit a virus or bacteria from binding to a host cell. The inhibition can be used in therapy for the flu, cancer, or AIDS. The CRM particles can be used, for example, to prepare metal nanoparticles or metal alloy nanoparticles, or they can be used in catalytic reactions.



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AQUEOUS SUSPENSION PREPARATION COMPRISING NANOPARTICLES OF MACROLIDE ANTIBACTERIAL AGENT

Nº publicación: US2016271057A1 22/09/2016

Solicitante:
ACTIVUS PHARMA CO LTD [JP]

Resumen de: EP3067045A1

[Problem] The purpose of the present invention is to provide an aqueous suspension preparation that comprises a macrolide antibacterial agent as an active component. Specifically, the purpose of the present invention is to provide a pharmaceutical composition that comprises a macrolide antibacterial agent as an active component and that can be put to practical use. [Solution] The present invention provides: an aqueous suspension preparation that is characterized by comprising nanoparticles of a macrolide antibacterial agent and a dispersion stabilizer; an aqueous suspension in which the average particle size of nanoparticles is 500 nm or less and the D90 particle size is 1,500 nm or less; a parenterally administered pharmaceutical composition that comprises this aqueous suspension preparation; an injection preparation; and eye drops or ear drops, more specifically, eye drops for the treatment or prevention of inflammatory diseases of the eye or ear drops for the treatment or prevention of inflammatory diseases of the ear.



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Micelle compositions and process for the preparation thereof

Nº publicación: US2016271062A1 22/09/2016

Solicitante:
DSM IP ASSETS BV [NL]

Resumen de: EP2382966A1

The present invention relates to a micelle composition comprising a hydrophobic compound and an amphiphilic block copolymer, wherein the amphiphilic block copolymer consists of a hydrophobic block A and a hydrophilic block B, the hydrophobic block A comprises at least one hydrophobic polymeric unit X and the hydrophilic block B comprises at least one hydrophilic polymeric unit Y whereby the X and Y blocks alternate. The present invention further relates to a process for the preparation of the micelle composition wherein the process comprises the steps of: a) dissolving the hydrophobic compound and the amphiphilic block copolymer in an organic solvent to form a solution, b) adding said organic solution into an aqueous medium, c) optionally repeating aforementioned steps. The micelle composition according to the present invention is useful in medical applications such as therapeutic cardiovascular applications, veterinary applications, food processing applications, flame retardant applications, coatings, adhesives and cosmetics, fabric/textiles, industrial and art applications.



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POLYMER NANOPARTICLES CONTAINING MULTIPLE AGENTS AND METHODS THEREOF

Nº publicación: US2016271072A1 22/09/2016

Solicitante:
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL [US]

Resumen de: WO2015061468A1

Disclosed herein are polymer nanoparticles comprising i. a nano-precipitated bioactive compound, wherein the nano-precipitate is encapsulated by a lipid, and ii. a hydrophobic bioactive compound. Also provided herein are methods for preparing the nanoparticles and compositions comprising the nanoparticles and methods for the treatment of a disease or an unwanted condition in a subject comprising administering the polymer nanoparticles.



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SYNTHESIS AND USE OF TARGETED RADIATION ENHANCING IRON OXIDE-SILICA-GOLD NANOSHELLS FOR IMAGING AND TREATMENT OF CANCER

Nº publicación: US2016271274A1 22/09/2016

Solicitante:
THE JOHNS HOPKINS UNIV [US]

Resumen de: WO2015070036A1

Magnetic iron oxide nanoparticles (MIONs) having silica (SiMION) and gold-silica (AuSiMION) nanoshells, methods of their preparation, and their use in cancer imaging and therapy applications are disclosed.



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NOVEL POLYMER PLATFORM TO PREPARE NANOHYDROGEL

Nº publicación: EP3068822A1 21/09/2016

Solicitantes:
MATRICARDI PIETRO [IT]
MEO CHIARA DI [IT]

Resumen de: WO2015071873A1

A method to prepare nanohydrogel comprising the steps of: - hydrophobic functionalization, wherein a polysaccharide is functionalized with a hydrophobic compound; self-assembling, wherein the functionalized polysaccharide obtained from the preceding step is subject to a self- assembling process in a water environment for the formation of nanohydrogel. The hydrophobic compound is riboflavin, or a derivative thereof, to which an alkyl group having a functional group suited to form a covalent bond with the polysaccharide has been bonded.



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MONO DISPERSE POLYMER NANOPARTICLES, FUNCTIONALIZED NANOPARTICLES AND CONTROLLED FORMATION METHOD

Nº publicación: EP3068598A1 21/09/2016

Solicitantes:
RAMAN SRIKAR [US]
KANNAN RAGHURAMAN [US]
VIMAL JATIN [IN]

Resumen de: WO2015061722A1

A method produces polymer nanoparticles. Polymer solution is sprayed through a nozzle toward a collector. An electric field is created at the nozzle, such as by a voltage is applied to the nozzle to create the electric field. The voltage applied to the nozzle is from ~10(Kilovolt) to ~30(Kilovolt), distance from nozzle tip to collector is from ~1(centimeter) to ~10 (centimeter) and the polymer concentration from ~0.01% to ~0.5% w/w. Preferably a grounded liquid collectors is used. The invention provides biocompatible monodisperse polymer nanoparticles having a size of less than ~300nm, preferably less than ~150nm. Payloads can be associated, and maintain efficacy, including more than one payload such as therapeutic agents and diagnostic agents on the same particles. Preferred particles are poly(methyl methacrylate) (PMMA-COOH) or acrylate analogues.



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TRANSDERMAL COLLOIDAL SOLUTION AGENT

Nº publicación: EP3069712A1 21/09/2016

Solicitante:
MEDRX CO LTD [JP]

Resumen de: WO2015072564A1

The present invention provides a transdermal solution agent which is obtained by colloidally dispersing a medicament or a salt thereof and phosphatidylcholine in propylene glycol or a propylene glycol-containing solution, and which exhibits excellent skin permeability of the medicament, while being reduced in the problem of skin irritation. A solution agent of the present invention has a modal value of particle diameters of around 100 nm, and has an average particle diameter within the range of 50-500 nm. The solution agent of the present invention achieves exponentially improved skin permeability by additionally containing an absorption enhancer such as triethanolamine.



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GENERATION OF MESOPOROUS MATERIALS USING MULTIPHASE SURFACTANT SYSTEMS

Nº publicación: WO2016145335A1 15/09/2016

Solicitantes:
STC UNM [US]
SANDIA CORP [US]

Resumen de: WO2016145335A1

The present invention relates to the discovery that mesoporous silica nanoparticles may be modified in pore size from the natural mesophase by generating mesoporous materials in binary, ternary or multiphase surfactant systems to produce biphasic, triphasic or multiphase mesophorous structures. Thus, the present invention relates to methods of producing biphase, triphasic and multiphase mesoporous stuctures with finely tuned mesopore size and protocells which are produced therefrom and mesoporous silica nanoparticles obtained therefrom. The resulting mesoporous nanostructures may be used to create protocells having unique cargo loading and release characteristics. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.



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PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

Nº publicación: WO2016144889A1 15/09/2016

Solicitante:
UNIV OF GEORGIA RES FOUND INC [US]

Resumen de: WO2016144889A1

Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.



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TARGETING TRASTUZUMAB-RESISTANT HER2+BREAST CANCER WITH A HER3-TARGETING NANOPARTICLE

Nº publicación: AU2015240460A1 15/09/2016

Solicitante:
CEDARS SINAI MEDICAL CENTER

Resumen de: WO2015154059A2

Disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to treatment with an anti-HER2 therapy; and administering to the patient a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; a nucleic acid molecule bound to the polypeptide sequence via electrostatic interactions; and a chemical agent non- covalently linked to the nucleic acid sequence. Also disclosed are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with the drug delivery molecule. Further disclosed herein are methods of treating cancer in a patient, the method comprising identifying a patient who is resistant to anti-HER2 therapy; and administering to the patient a therapeutically effective amount of a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence. Finally disclosed herein are methods of inducing apoptosis in an anti-HER2 therapy resistant HER2+ breast cancer cell, the method comprising contacting the anti-HER2 therapy resistant HER2+ breast cancer cell with a drug delivery molecule, comprising a polypeptide molecule adapted to target and/or penetrate a type of cell; and a sulfonated corrole molecule bound to the polypeptide sequence



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NANOSUSPENSION OF NATURAL MATERIALS AND PREPARATION METHOD THEREOF

Nº publicación: AU2015212726A1 15/09/2016

Solicitante:
APURANO PHARMACEUTICALS GMBH

Resumen de: WO2015114164A1

The present disclosure relates to a method for the preparation of a nanosuspension of at least one natural material, wherein the method comprises the steps of (a) providing at least one natural material having a particle size (D90) of less than 320 μm; (b) dispersing said at least one natural material of step (a) in a solvent; and (c) milling the dispersion of step (b) to a particle size (D90) of below 1000 nm. The nanosuspension is useful for the preparation of a medicament.



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POLYVALENT RNA-NANOPARTICLE COMPOSITIONS

Nº publicación: AU2016219644A1 15/09/2016

Solicitante:
UNIV NORTHWESTERN

Resumen de: WO2010060110A1

The present invention concerns nanoparticles functionalized with duplex RNA for a variety of uses, including but not limited to gene regulation. More specifically, the disclosure provides a new strategy for conjugating RNA to a nanoparticle to achieve increased stability and activity.


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