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Resultados 101 resultados LastUpdate Última actualización: 29/06/2016 [21:34:00] pdf PDF




Solicitudes de Patente publicadas en los últimos 30 días / Patent Applications last 30 days publications



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TELODENDRIMERS AND NANOCARRIERS AND METHODS OF USING SAME

Nº publicación: EP3035968A2 29/06/2016

Solicitante:
UNIV NEW YORK STATE RES FOUND [US]

Resumen de: US2015056139A1

Provided are functional segregated telodendrimers having, for example, two or three functional segments. The telodendrimers can have one or more crosslinking groups (e.g., reversible photocrosslinking groups). The telodendrimers can aggregate to form nanocarriers. Cargo such as drugs, imaging probes, and other materials may be sequestered in the core of the aggregates via non-covalent or covalent interactions with the telodendrimers. Such nanocarriers may be used in drug delivery applications and imaging applications.



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AGGLOMERATING MAGNETIC ALKOXYSILANE-COATED NANOPARTICLES

Nº publicación: EP3038115A1 29/06/2016

Solicitante:
MAGFORCE AG [DE]

Resumen de: WO2013020701A2

The present invention relates to a method for producing a suspension of agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein an aqueous suspension of magnetic metal nanoparticles is incubated with alkoxysilane, wherein the incubation is carried out essentially in the absence of an organic solvent. The present invention further relates to suspension of agglomerates of magnetic alkoxysilane-coated metal containing nanoparticles obtainable by the method of the present invention and to a composition comprising agglomerates of magnetic alkoxysilane-coated metal nanoparticles, wherein the agglomerates have an average size of 30 to 450 nm, preferably of 50 to 350 nm and especially of 70 to 300 nm as determined by light scattering.



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Method and apparatus for acne treatment

Nº publicación: EP3037131A2 29/06/2016

Solicitante:
GENTLEWAVES LLC [US]

Resumen de: US2006212025A1

Disclosed is a system and method for treatment of skin disorders. More particularly, the disclosed invention is directed toward the reduction of acne and acne related bacteria using low-intensity light therapy. In an illustrative embodiment, skin containing acne bacteria is treated with a series of pulses of light from a light emitting diode. The LED has a dominant emissive wavelength of about 660 nm and an energy output of about 4 mW. The acne bacteria-containing tissue is exposed to pulses from the light source about 100 times for about 250 milliseconds per pulse, with an interpulse interval of about 100 milliseconds.



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PEPTIDIC NANODELIVERY COMPOSITION TARGETING TWO RECEPTORS

Nº publicación: EP3035969A1 29/06/2016

Solicitantes:
MOGHIMI SEYED MOIEN [DK]
WU LINPING [DK]
AHMADVAND DAVOUD [DK]
PARHAMIFARR LADAN [DK]
ANDRESEN THOMAS LARS [DK]

Resumen de: WO2015024931A1

A polypeptide conjugate for use in a method for binding and/or internalization of the polypeptide conjugate to a mammalian cell having a transferrin receptor (TFRC) and/or receptor for advanced glycation end products (RAGE). The polypeptide conjugate may be used in a method for targeting of a drug delivery system or diagnostic delivery system.



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BIOLOGICALLY ACTIVE SYNTHETIC NANOPARTICLE CONSTRUCTS AND MEHTODS OF USE THEROF

Nº publicación: EP3035917A2 29/06/2016

Solicitante:
UNIV RUTGERS [US]

Resumen de: WO2015027243A2

This application discloses the compositions comprising biologically active synthetic nanoparticie constructs and methods of use thereof to modify gene expression including transcriptional activation and transcriptional repression.



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GOLD NANOFLOWER STRUCTURE AND GOLD NANOFLOWER/QUANTUM DOT COMPOSITE PROBE FOR LIVING CELL IMMUNOFLUORESCENT LABELING AND PHOTOTHERMAL THERAPY

Nº publicación: EP3037195A1 29/06/2016

Solicitante:
FIRST AFFILIATED HOSPITAL OF ANHUI MEDICAL UNIVERSITY [CN]

Resumen de: WO2015024274A1

The present invention provides are a gold nanoflower structure and a preparation method therefor. The gold nanoflower structure is a gold nanoflower particle, with round-head columns being uniformly distributed at the periphery thereof, obtained by using gold octahedrons, gold balls or gold tetrahedrons as seed crystals and reducing chloroauric acid by using weak reductant in an environment of high-concentration polyvinylpyrrolidone. In addition, also provided in the present invention are a gold nanoflower/quantum dot composite probe for living cell immunofluorescent labeling and photothermal therapy, a preparation method therefor and a use thereof. In comparison with traditional probes, the probe, incorporates the features of photothermal therapy and fluorescent labeling, and is capable of killing cancer cells in an effective and directional way. Two light sources are adopted to bring a tremendous photothermal conversion efficiency and a greater enhancement on fluorescence intensity of quantum dots respectively, thus mutual interference of two effects are avoided tactfully. The coating of silicon dioxide averts the biotoxicity of the gold nanoflower and the quantum dot effectually, enabling the surface of the composite probe to be easily functionalized and also imparting an extraordinarily excellent biocompatibility to the composite probe.



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INHALABLE PHARMACEUTICAL COMPOSITIONS

Nº publicación: NZ619041A 24/06/2016

Solicitante:
BERG LLC

Resumen de: WO2012174559A1

Inhalable pharmaceutical compositions can include an aqueous dispersion of particles including a hydrophobic bioactive agent (e.g., CoQIO) suitable for continuous aerosolization. Due to their chemical composition and methods of manufacture, the pharmaceutical compositions exhibit distinctive physicochemical properties that provide advantageous aerosol transmission and output.



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Soft chewable pharmaceutical products

Nº publicación: NZ631100A 24/06/2016

Solicitante:
INTERVET INT BV

Resumen de: NZ631100A

Disclosed herein are chewable veterinary pharmaceutical products comprising pamoic acid or a pharmaceutically acceptable salt thereof, provided that such pamoic acid or pharmaceutically acceptable salt thereof is not an active pharmaceutical ingredient, a liquid component, a forming agent, optionally one or more active pharmaceutical ingredients, and optionally one or more excipients. Also disclosed is a process for the manufacture of such soft chewable pharmaceutical products and their use in medicaments for preventing parasites, acarids or nematodes. In a preferred embodiment the products comprise an isoxazoline compound of formula I where the substituents are as defined herein.



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LIPID NANOPARTICLE OF TOBRAMYCIN

Nº publicación: WO2016097444A1 23/06/2016

Solicitantes:
BIOPRAXIS RES AIE [ES]
UNIV PAIS VASCO [ES]
UNIV BARCELONA [ES]
FUNDACI\u00D3 D INVESTIGACI\u00D3 SANIT\u00C0RIA DE LES ILLES BALEARS [ES]
CONSEJO SUPERIOR INVESTIGACION [ES]

Resumen de: WO2016097444A1

The invention relates to: a lipid nanoparticle comprising at least one tobramycin antibiotic, a lipid fraction, and one or more surfactants; and the use of the nanoparticle in the prevention and/or treatment of infections of the respiratory tree.



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POLYSACCHARIDE COMPOSITIONS FOR ABSORBING AQUEOUS LIQUID

Nº publicación: US2016175811A1 23/06/2016

Solicitante:
DU PONT [US]

Resumen de: US2016175811A1

Compositions are disclosed herein comprising poly alpha-1,3-glucan or poly alpha-1,3-1,6-glucan polymer having an open-cell pore structure with an average pore size of about 100 nm to about 3000 nm in diameter. Such polymers have enhanced aqueous liquid absorption capacity, and can be comprised in various products having aqueous liquid absorption function. Methods of preparing glucan polymers of the compositions provided herein are also disclosed.



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DYNAMIC BIO-NANOPARTICLE ELEMENTS

Nº publicación: US2016178652A1 23/06/2016

Solicitantes:
VITALIANO FRANCO [US]
VITALIANO GORDANA DRAGAN [US]

Resumen de: US2010226856A1

The invention in suitable embodiments is directed to dynamic bio-nanoparticle elements and bio-nanoparticle platforms employing such bio-nanoparticle elements. In one aspect, one or more elements of one or more types, formed from isolated, synthetic and or recombinant amino acid residues comprising in whole or in part one or more types of Clathrin and or Coatomer I/II proteins of one or more isoforms, execute one or more functions and or effect one or more ends, in vivo and or in vitro.



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PEPTIDE CONJUGATED PARTICLES

Nº publicación: EP3033102A2 22/06/2016

Solicitante:
UNIV NORTHWESTERN [US]

Resumen de: WO2015023796A2

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).



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METHOD FOR PREPARING METAL NANOSTRUCTURE BASED ON BIOMOLECULES

Nº publicación: EP3034462A1 22/06/2016

Solicitante:
UNIV KOREA RES & BUS FOUND [KR]

Resumen de: WO2015023059A1

The present invention relates to a method for preparing a metal nanostructure using a DNA and, more specifically, to a method for preparing a metal nanostructure, which easily controls the orientation, form and size compared to a conventional bottom-up method due to using a DNA having a self-assembling property as a frame. The metal nanostructure prepared by the method exhibits an excellent localized surface plasmon resonance phenomenon, and thus can be used as a fluorescent material in drug delivery, biomedical imaging, supersensitive biosensors, etc.



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A NOVEL PLGA-MODIFIED POLYETHYLENIMINE SELF-ASSEMBLY NANOTECHNOLOGY FOR NUCLEIC ACID AND DRUG DELIVERY

Nº publicación: EP3033113A1 22/06/2016

Solicitante:
BAYLOR COLLEGE MEDICINE [US]

Resumen de: WO2015023775A1

Embodiments of the invention concern copolymers and nanoparticles for use as delivery agents for one or more agents for therapy for a medical condition of humans and animals. Some of embodiments of the invention provide new reagents for biomedical research in cell culture, animal models and plants, for example. The copolymers comprise PLGA and PEI and, in some embodiments, also comprise l-(3-aminopropyl)-4-methylpiperazine (APMP), Fc binding peptide and/or antibody. In certain embodiments, APMP-PLGA-PEI, Fc binding peptide/antibody-PLGA-PEI or Fc binding peptide/antibody-APMP-PLGA-PEI nanoparticles comprising one or more therapeutic agents are delivered to an individual in need thereof or used for biomedical research in cell cultures, animal models and plants.



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Functional PLA-PEG copolymers, the nanoparticles thereof, their preparation and use for targeted drug delivery and imaging

Nº publicación: EP3034498A1 22/06/2016

Solicitante:
SANOFI SA [FR]

Resumen de: EP2634179A1

The present invention concerns novel functional PEG-PLA containing copolymers, the nanoparticles containing the same, their process of preparation and their use for site specific targeted drug delivery and imaging.



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processo de formulação de nanopartículas de apocinina revestidas com o polímero natural bsa e reticuladas com glutaraldeído pelo método de coacervação e fármaco

Nº publicación: BR102014029625A2 21/06/2016

Solicitante:
UNIV ESTADUAL DO CT OESTE UNICT PR [BR]

Resumen de: BR102014029625A2

processo de formulação de nanopartículas de apocinina revestidas com o polímero natural bsa e reticuladas com glutaraldeído pelo método de coacervação e fármaco. a presente invenção refere-se a um processo de formulação para o desenvolvimento de nanopartículas poliméricas contendo apocinina a partir do polímero natural, albumina de soro bovino (bsa) e do agente reticulante glutaraldeído pelo método de coacervação. o processo desta invenção possibilita a obtenção de produtos em escala nanométrica com valor considerável de encapsulação da substância ativa, assim como uma melhora das propriedades físico-químicas, aumentando a estabilidade em meios fisiológicos, circulação sistêmica prolongada, cinética de liberação sustentada e direcionáveis aos locais de ação desejados.; sendo assim, a presente invenção consiste numa estratégia interessante por elevar a biodisponibilidade e direcionamento in vivo da apocinina, alterando a farmacocinética e a biodistribuição do fármaco.



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LIPID NANOPARTICLE OF TOBRAMYCIN

Nº publicación: ES2574615A1 21/06/2016

Solicitantes:
BIOPRAXIS RES AIE [ES]
UNIV DEL PAIS VASCO/EUSKAL HERRIKO UNIBERTSITATEA [ES]
UNIV BARCELONA [ES]
FUND D'INVESTIGACIO SANIT\u00C0RIA DE LES ILLES BALEARS [ES]
CONSEJO SUPERIOR DE INVESTIG CIENTIFICAS [ES]

Resumen de: WO2016097444A1

The invention relates to: a lipid nanoparticle comprising at least one tobramycin antibiotic, a lipid fraction, and one or more surfactants; and the use of the nanoparticle in the prevention and/or treatment of infections of the respiratory tree.



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GENERATION OF HEMOGLOBIN-BASED OXYGEN CARRIERS USING ELASTIN-LIKE POLYPEPTIDES

Nº publicación: WO2016094627A1 16/06/2016

Solicitante:
AIMA HOLDING COMPANY LLC S [US]

Resumen de: WO2016094627A1

Described herein is the use of elastin-like polypeptides to generate hemoglobin-based oxygen carriers as a means of preventing and treating conditions caused by blood loss or anemia, for example, hemorrhagic shock. Elastin-like polypeptides are capable of creating therapeutically functional fusion proteins through genetic engineering with a therapeutic agent, for example, hemoglobin and biologic equivalent thereof. Specific forms of these fusion proteins have the ability to form into spherical nanoparticles possessing a therapeutically agent at their core. This provides a unique basis for employing elastin-like polypeptides as hemoglobin carriers in the manufacture of blood substitutes.



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COMPOSITION COMPRISING ROD-SHAPED NANOPARTICLES AND NUCLEIC ACID

Nº publicación: WO2016093358A1 16/06/2016

Solicitantes:
UNIV HOKKAIDO NAT UNIV CORP [JP]
JAPAN AS REPRESENTED BY THE DIRECTOR GENERAL OF NAT INST OF INFECTIOUS DISEASES [JP]
KYOWA HAKKO BIO CO LTD [JP]

Resumen de: WO2016093358A1

The present invention addresses the problem of providing a composition comprising nanoparticles and nucleic acid, the composition having an enhanced adjuvant effect. The present invention provides a composition comprising rod-shaped nanoparticles and nucleic acid. Examples of preferred rod-shaped nanoparticles include particles made of gold, platinum, silver, titanium oxide, silica, silicon, biodegradable polymers, and other such materials, the particles having a short-axis length of 4-20 nm and a long-axis length 2-20 times the short-axis length. Examples of preferred nucleic acids include double-stranded ribonucleic acid having a weight-average chain length within a range of 0.1-2.0 kbp. In a preferred embodiment, the composition contains complexes of rod-shaped nanoparticles and nucleic acid.



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Nano carrier prepared from marine sulfated polysaccharide, nano complex and application of nano carrier

Nº publicación: WO2016090873A1 16/06/2016

Solicitante:
OCEAN UNIV CHINA [CN]

Resumen de: CN104436205A

The invention discloses a nano carrier prepared from marine sulfated polysaccharide, a nano complex, and an application of the safe and nontoxic nano carrier with specific activity of the marine sulfated polysaccharide. According to the technique, the nano carrier is prepared from marine sulfated polysaccharide with certain biological activity as an edible and safe water-soluble biological macromolecular material by using intermolecular crosslinking and compounding of the marine sulfated polysaccharide and chitosan and derivatives of the chitosan; a hydrophobic microdomain formed by convolving between polysaccharide molecules is beneficial to adsorption and aggregation of fat-soluble active substances; entrapment and dispersion of a water-soluble nano carrier on the fat-soluble active substances are achieved; and the nano complex with good biological activity is formed. The prepared nano complex is beneficial to transportation and absorption of the active substances in vivo; and the bioavailability of the active substances is improved.



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NANOPARTICLES AND METHODS OF PRODUCING THE SAME

Nº publicación: US2016166513A1 16/06/2016

Solicitante:
UNIV ILLINOIS [US]

Resumen de: WO2015006735A1

The present disclosure provides methods and compositions related to nanoparticles comprising an encapsulated hydrophobic drug. The methods described herein provide nanoparticles having a small size and a narrow size distribution.



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NANOEMULSIONS OF HYDROPHOBIC PLATINUM DERIVATIVE

Nº publicación: US2016166507A1 16/06/2016

Solicitante:
NEMUCORE MEDICAL INNOVATIONS INC [US]

Resumen de: WO2015013566A1

Provided are nanoemulsion formulations useful for the delivery of hydrophobic platinum chemotherapeutic drugs to cancer patients, as well as methods of their preparation and use.



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IMPROVED FORMULATIONS FOR VIROSOMES

Nº publicación: AU2014368594A1 16/06/2016

Solicitante:
CRUCELL HOLLAND BV

Resumen de: WO2015091798A2

The present invention provides virosome formulations, in particular liquid pharmaceutical formulations comprising virosomes.



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LIVER CANCER RELATED GENES-SPECIFIC siRNA, DOUBLE-STRANDED OLIGO RNA MOLECULES COMPRISING THE siRNA, AND COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING THE SAME

Nº publicación: US2016168573A1 16/06/2016

Solicitantes:
BIONEER CORP [KR]
SANOFI AVENTIS KOREA CO LTD [KR]

Resumen de: WO2015005669A1

There is provided a liver cancer related specific siRNA and high efficiency double-stranded oligo RNA molecules containing the same. The double-stranded oligo RNA molecules have a structure in which hydrophilic and hydrophobic compounds are conjugated to both ends of the double-stranded oligo RNA molecules by a simple covalent bond or a linker-mediated covalent bond in order to be efficiently delivered into cells and may be converted into nanoparticles in an aqueous solution by hydrophobic interactions of the double-stranded oligo RNA molecules. The siRNA contained in the double-stranded oligo RNA molecules may be liver cancer related genes, particularly Gankyrin or BMI-1 specific siRNA. In addition, the present invention relates to a method of preparing the double-stranded oligo RNA molecules, and a pharmaceutical composition for preventing or treating cancer, particularly, liver cancer, containing the double-stranded oligo RNA molecules.



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Nanobubbles

Nº publicación: US2016166716A1 16/06/2016

Solicitante:
PURDUE RESEARCH FOUNDATION [US]

Resumen de: US2016166716A1

The present invention provides a nanobubble comprising a continuous outer shell, the outer shell comprising a cross-linked polymeric material, an inner wall of the continuous outer shell and a hollow core within the continuous outer shell. The nanobubble may be less than 250 nm in diameter. In a further aspect of the invention, the cross-linked polymeric material is a cellulose-based material.


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