Resumen de: US2019071695A1

An intracellular delivery system and method are provided. The intracellular delivery system comprises a laser-activated surface and cells positioned at a distance from the laser-activated surface. A laser provided a laser pulse that is used to porate membranes of the cells to deliver or extract cargo from the cells into a liquid surrounding the cells. The method of intracellular delivery comprises positioning a laser-activated surface at a distance from cells and applying a laser pulse from the laser to the surface to porate membranes of the cells to deliver or extract cargo from the cells into a liquid surrounding the cells.

Resumen de: EP3677270A1

Disclosed is a selenium-doped black phosphorus prodrug comprising selenium-doped black phosphorus nanosheets and polyethylene glycol amine coating the surface of the selenium-doped black phosphorus nanosheets. The selenium-doped black phosphorus nanosheets comprise black phosphorus nanosheets and selenium elements doped in the black phosphorus nanosheets, with the selenium elements replacing positions of a portion of the phosphorus atoms in the black phosphorus crystal lattice. The selenium-doped black phosphorus prodrug is a controlled-release prodrug of selenium elements, which can realize the near-infrared light controlled-release of selenium elements, thereby controllably regulating selenium content in the human body, regulating human immunity, and preventing and treating cancers. Also provided is a method for preparing the selenium-doped black phosphorus prodrug.

Resumen de: WO2019046211A1

Provided herein are nanocapsules comprising a single ribonucleoprotein (RNP) complex as a core and an biodegradable crosslinked polymer shell that encapsulates the core, wherein the RNP complex comprises a Cas9 polypeptide and a guide RNA, and the biodegradable crosslinked polymer shell comprises polymerized monomers of imidazolyl acryloyl monomers, bisacryloyl disulfide monomers (a biodegradable cross-linker), optionally PEG acryloyl monomers, and either cationic acryloyl monomers, anionic acryloyl monomers, or both cationic and anionic acryloyl monomers (optionally in combination with non-ionic acryloyl monomers) as defined herein. Also provided are methods of making the nanocapsules, kits containing the nanocapsules and methods of delivering the encapsulated RNP to cells.

Resumen de: WO2019046809A1

The disclosure features novel methods of producing nucleic acid lipid nanoparticle (LNP) compositions employing a modifying agent after formation of a precursor nucleic acid lipid nanoparticle, the produced compositions thereof, and methods involving the nucleic acid lipid nanoparticles useful in the delivery of therapeutics and/or prophylactics, such as a nucleic acid, to mammalian cells or organs to, for example, to regulate polypeptide, protein, or gene expression.

Resumen de: CN111374961A

本发明属于医药技术领域，具体涉及一种含有喹诺酮类化合物的纳米粒，所述纳米粒为喹诺酮类化合物在表面吸附了一种或多种表面稳定剂以维持纳米粒的有效平均粒径1～1000nm，还可以与植物提取物形成含有喹诺酮类化合物的组合物，所述含有喹诺酮类化合物的纳米粒或组合物可用于协同抑制肿瘤细胞增殖作用，所述肿瘤选自肺癌、结肠癌、白血病、黑色素瘤、鼻咽癌、卵巢癌、乳腺癌、肝癌、胃癌、前列腺癌，降低了治疗成本。

Resumen de: CN111375053A

本发明提供一种有效的、安全的口服型重组人乳铁蛋白丝胶纳米颗粒的制备方法及应用，能够提高rhLF细胞摄入效率，抑制LPS诱导的巨噬细胞产生炎性以及治疗DSS诱导急性结肠炎。本发明以rhLF转基因蚕茧为原料，通过丝胶提取，透析及乙醇诱导制备了一种含有rhLF的丝胶纳米颗粒，直接用于结肠炎的口服治疗，适用于大规模生产，操作简单，应用价值高。

Resumen de: CN111374960A

本发明涉及一种EGFR受体靶向的放射性纳米颗粒及其制备方法，其组成包括粒径为5‑10nm的铁氧化物纳米颗粒、聚丙烯酸、顺铂、多巴胺、含有酪氨酸‑组氨酸‑色氨酸‑酪氨酸‑甘氨酸‑酪氨酸‑苏氨酸‑脯氨酸‑谷氨酰胺‑天冬酰胺‑缬氨酸‑异亮氨酸‑赖氨酸‑叠氮乙酸‑的GE11小肽(Y‑H‑W‑Y‑G‑Y‑T‑P‑Q‑N‑V‑I‑K‑(CH)‑N)、含有铜‑64(Cu)的放射性核素。与现有技术相比，本发明所制备的纳米颗粒可用于PET/MRI/PAI成像诊断引导的放疗‑化疗联合治疗。

Resumen de: CN111363746A

本发明提供了抑制HMGB1基因的siRNA、包载siRNA的稳定核酸脂质纳米粒及其应用，所述的siRNA分子的正义链为SEQ ID NO：1，反义链为SEQ ID NO：2。本发明具有如下技术效果：本发明将针对HMGB1的siRNA包载在稳定核酸脂质纳米粒中，避免其被体内酶降解，制备的纳米粒具有显著性的抗炎效果，可以将针对HMGB1的siRNA靶向递送到肝巨噬细胞释放，增强抗炎的效果，从而更好地治疗NASH。

Resumen de: CN111358946A

本发明提供了一种金属‑ICG配合物及制备方法、金属‑ICG配合物白蛋白纳米颗粒及制备方法和应用，涉及纳米药物技术领域，所述金属‑ICG配合物的金属离子选自金、铂、锌、铜、钴、铁、镍和锰中的至少一种；改善现有的声敏剂种类少、最大照射波长短和治疗窗口窄的技术问题，本发明提供的金属‑ICG配合物中金属离子和ICG以配位键络合，扩展了声敏剂的种类，拓宽了声敏剂的照射波长，扩大了治疗窗口，兼具光敏和声敏双重功能，能够有效推动光热和声动力治疗的发展。

Resumen de: WO2020114460A1

A multimeric albumin nanosphere, a preparation method therefor, use thereof, a drug-loaded multimeric albumin nanosphere, a preparation method therefor and use thereof, relating to the technical field of biomedical materials. The multimeric albumin nanosphere is mainly formed by means of aggregation of a plurality of albumin molecules, the plurality of albumin molecules are linked by means of disulfide bonds, and the particle size of the multimeric albumin nanosphere is 10 to 100 nm. The technical problem of poor stability and possible toxic side effects of albumin nanospheres in the prior art is alleviated. The multimeric albumin nanosphere is composed of a plurality of albumin molecules linked by disulfide bonds, has a small particle size, narrow distribution, uniform size, and good dispersibility, and is a good carrier for drug delivery, achieving technical effects of effective, safe and stable drug release in patients for a long time.

Resumen de: FR3091177A1

Nanoparticules et procédé de préparation La présente invention concerne des nanoparticules de métal choisi parmi platine, or ou bismuth, fonctionnalisées à leur surface par du polyéthylène glycol fonctionnalisé notamment comprenant au moins une fonction OH, COOH, NH2 ou SH, et leur procédé de préparation comprenant les étapes suivantes : a) Mélanger un précurseur de nanoparticules avec un polyéthylène glycol fonctionnalisé notamment comprenant au moins une fonction OH, COOH, NH2 ou SH dans de l’eau ; b) Exposer le mélange au rayonnement ionisant. Figure pour l'abrégé : néant

Resumen de: CN111358958A

本发明公开了一种简便、快速的制备高稳定性的基因递送纳米系统方法。本方法以点击化学为依据，利用叠氮基团和二苯并环辛炔基团的选择性点击化学反应，有效的交联纳米系统，提高系统的胶体稳定性，实现体内基因递送。

Resumen de: CN111358954A

本发明公开了一种具备靶向调节巨噬细胞极化功能的组合物及其制备方法和用途，该组合物包括可靶向巨噬细胞的靶向载体以及包被在该靶向载体内的纳米氧化铁。本发明通过靶向载体包被纳米氧化铁，改变纳米氧化铁的表面结构和性能，使得纳米氧化铁能较好地躲避巨噬细胞的识别，从而减少巨噬细胞对纳米粒子的吞噬，增加纳米氧化铁对肿瘤组织的主动靶向性，而且纳米氧化铁颗粒具有极化巨噬细胞的潜能，能够改变肿瘤微环境成分，从而抑制肿瘤的复发和转移。

Resumen de: CN111358767A

本发明公开了一种肿瘤微环境敏感多糖基纳米粒子的制备方法，其特征在于，包括如下步骤：步骤S1、NaSO纳米线的合成；步骤S2、多糖基单体聚合；步骤S3、交联；步骤S4、透析处理、冷冻干燥。本发明还公开了根据所述一种肿瘤微环境敏感多糖基纳米粒子的制备方法制备得到的肿瘤微环境敏感多糖基纳米粒子。本发明公开的肿瘤微环境敏感多糖基纳米粒子肿瘤微环境敏感性好、使用绿色安全环保，产量高，粒径分布均一，能有效提高药物释放选择性。

Resumen de: WO2019139650A2

The methods described herein, referred to as particle-templated emulsification (PTE), provide an improved approach for generating a monodisperse emulsion that encapsulates target particles of interest without requiring the use of a microfluidic device. Monodisperse droplets may be effectively obtained by using monodisperse particles to template the formation of droplets, which can include, e.g., monodisperse single-emulsion droplets, multiple-emulsion droplets, or Giant Unilamellar Vesicles (GUV), without destroying the integrity of the droplets.

Resumen de: WO2018220376A1

The invention relates to microbubble complexes for use in methods of sonodynamic therapy which comprise a microbubble attached to or otherwise associated with one or more linking groups, each linking group being bound to at least one sonosensitising agent and at least one chemotherapeutic agent. It further relates to the microbubble complexes themselves and to pharmaceutical compositions which contain them. The invention is particularly suitable for the treatment of deep-sited tumors, in particular pancreatic cancer.

Resumen de: US2019151340A1

The present invention relates to polymeric nanoparticles comprising bortezomib and methods for treating certain diseases comprising administering these polymeric nanoparticles to a subject in need thereof.

Resumen de: US2019055263A1

The present disclosure provides crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, pharmaceutical compositions comprising crystalline polymorphic forms of TG02 free base and TG02 acid addition salts, and methods of treating cancer and other diseases in a patient with crystalline polymorphic forms of TG02 free base and TG02 acid addition salts.

Resumen de: CN111358766A

本发明公开了一种包载他扎罗汀的PLGA纳米粒及其制备方法、用途,包载他扎罗汀的PLGA纳米粒中包括他扎罗汀和PLGA,以他扎罗汀作为主药,以PLGA为载体,他扎罗汀与PLGA的质量比为1:10,本发明提供的包载他扎罗汀的PLGA纳米颗粒，纳米粒平均粒径为149.2±4.9nm。本发明方法中，可制得平均粒径较小的包载他扎罗汀的PLGA纳米颗粒，长期稳定性好，有利于其在生物体内的稳定释放，具有良好的细胞相容性和组织相容性，并且在靶向治疗深部组织压力性损伤中相对于裸药他扎罗汀具有更好的疗效。

Resumen de: WO2018167618A1

Compositions and their use are described for delivery of drugs to desired tissues via a light responsive quantum dot (QD) drug delivery system (QD-DDS). The QD-DDS comprises water soluble QD nanoparticles loaded with drug molecules that are releasable from the QD-DDS upon light administration at a wavelength absorbed by the QD.

Resumen de: WO2018195526A1

Disclosed is a nanoparticle comprising an inner core comprising a virus; and an outer surface comprising a cellular membrane derived from a cell, and process of making thereof. The virus is an oncolytic virus and cellular membrane is derived from for example red blood cells.

Resumen de: WO2018201157A1

Modified hydrophilic carbon clusters (HCCs), poly(ethylene glycol)-hydrophilic carbon clusters (PEG-HCCs) and similarly structured materials like graphene quantum dots (GQDs), PEGylated GQDs, small molecule antioxidants, and PEGylated small molecule antioxidants. These materials have been modified with an iron chelating moiety, deferoxamine, or a similar chelating moiety. By exploiting common binding sites, the carbon nanostructure facilitates intracellular transport including in mitochondria, reduces oxidative breakdown of the chelator moiety prior to treatment, and reduces both the cause and consequences of metal induced oxidative stress within the body thus providing a novel form of therapy for a range of oxidative and metal-related toxicities. Grapheme materials can be used for the treatment of acute and chronic mitochondrial electron transport chain dysfunction.

Resumen de: WO2018208700A1

The present invention generally relates to targeted nanoparticle delivery to E-selectin- or P-selectin-positive cells or tissues. In particular, this invention discloses a method for preparing quinic acid-modified nanoparticles for targeted drug delivery to cancerous cells or tissues via E-selectin- or P-selectin-mediated transcytosis. The invention described herein also pertains to pharmaceutical compositions and methods for treating cancers.

Resumen de: WO2018205022A1

There is provided an ocular drug delivery formulation comprising a delivery carrier comprising a cellulosic polymer and an anionic polysaccharide and nanoparticles comprising an amphiphilic non-ionizable block copolymer and a cannabinoid. The formulation has a gel point of about 30°C to about 37°C.

Resumen de: AU2020203824A1

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).