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Resultados 187 resultados LastUpdate Última actualización 18/02/2018 [15:24:00] pdf PDF




Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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CHIA OIL EDIBLE NANOEMULSION

NºPublicación: WO2018029626A1 15/02/2018

Solicitante:
CONSEJO NACIONAL DE INVESTIGACIONES CIENT\u00CDFICAS Y TECN CONICET [AR]
UNIV DE BUENOS AIRES [AR]
DE CUNTO FARIAS SRL [AR]
MARTINEZ MAR\u00CDA JULIA [AR]

Resumen de: WO2018029626A1

An edible chia oil nanoemulsion, rich in omega-3, with a high physical and oxidative stability, high bioaccessibility of omega-3 fatty acids and preparation methods. In particular, it discloses a chia oil nanoemulsion comprising between 10% and 20% of chia oil (Salvia hispanica L.), between 2% and 5% of polysorbate, between 0.5% and 5% of at least one emulsifier other than the polysorbate, between 0.05% and 0.2% of at least one antioxidant and water. In some specific preparations, the chia oil nanoemulsion of this invention may also comprise at least one pH modifier. In other specific preparations, the chia oil nanoemulsion of this invention may also comprise one or more polysaccharides. In other specific preparations, the chia oil nanoemulsion of this invention may also comprise one or more sugars. Also, edible formulations are disclosed, comprising chia oil nanoemulsions and, in particular, transparent drinks and desserts, such as juices and jellies with such nanoemulsions.



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NOVEL LIGHT-ACTIVATED COMPOSITIONS AND METHODS USING THE SAME

NºPublicación: US2018043022A1 15/02/2018

Solicitante:
THE REGENTS OF THE UNIV OF COLORADO A BODY CORPORATE [US]

Resumen de: US2018043022A1

The invention includes light-activated compositions and methods that are useful for promoting cell death or growth. In certain embodiments, the compositions comprise quantum dots (QD).



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Pharmaceutical composition containing camptothecin polymer derivative

NºPublicación: AU2016314090A1 15/02/2018

Solicitante:
NIPPON KAYAKU KK

Resumen de: AU2016314090A1

[Problem] The problem is to provide a pharmaceutical formulation containing a polymerized camptothecin derivative obtained by bonding a camptothecin derivative having the ability to form nanoparticles by association in aqueous solution to a polymer carrier, wherein the pharmaceutical formulation composition has improved formulation stability. In particular, the problem is to provide a pharmaceutical formulation having excellent storage stability that maintains the ability to form nanoparticles and the camptothecin derivative bonding stability, which are important factors. [Solution] A pharmaceutical formulation containing a block copolymer linking a polyethylene glycol segment and a polyglutamic acid segment including a camptothecin derivative bonded to a glutamic acid unit, and a saccharide, wherein the pharmaceutical formulation forms aggregates in aqueous solution, and the change in the scattered light intensity of the aggregates in the pharmaceutical formulation is 20% or less after the pharmaceutical formulation has been stored for four weeks at 40°C shielded from light.



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PH-sensitive linkers for delivering a therapeutic agent

NºPublicación: AU2016295602A1 15/02/2018

Solicitante:
GNT BIOTECH & MEDICALS CORP

Resumen de: AU2016295602A1

A pH-sensitive linker having the following Formula (I). Wherein X is (II); P is -C (O) NH- or -C (O) O-; Q is -R (CH2CH2O) m-, R (-C (O) NH-) z or -R [-C (O) CH2CH2-C (O) NH- (CH2CH2O) m] Y; R is a bond, -C1-12alkyl or C1-10alkoxy; m is 1 to 12; z is 1 to 4; and Y is 1 to 12. The linker can simultaneously bind metallic nanoparticles and one or more agents with various molecular size.



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Method of attacking target cells

NºPublicación: AU2016308859A1 15/02/2018

Solicitante:
SANDSTROM ROBERT

Resumen de: AU2016308859A1

A method of killing cells of a targeted cell type in a patient body that utilizes nanoparticles (10) having a first portion (12), which when exposed to a target portion (14) of a targeted cell type (16), binds to the target portion and a second portion (10A), joined to the first portion, and comprised of a low resistivity material. The nanoparticles are introduced into a contact area where they contact cells of the targeted cell type. Contemporaneously, the contact area is exposed to a varying magnetic field of insufficient strength to increase the temperature of any part of the patient body by more than ten degrees Celsius, but which creates a current (20) at the nanoparticles sufficient to disrupt function of the targeted cell type.



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BIMETAL-CONDUCTIVE POLYMER JANUS COMPOSITE NANOSTRUCTURE HAVING ELECTRICAL STIMULUS RESPONSE, COLLOID SELF-ASSEMBLED STRUCTURE THEREOF, PREPARING METHOD, AND BIO-SENSING, BIO-IMAGING, DRUG DELIVERY, AND INDUSTRIAL APPLICATION

NºPublicación: WO2018030785A1 15/02/2018

Solicitante:
INDUSTRY UNIV COOPERATION FOUNDATION HANYANG UNIV ERICA CAMPUS [KR]

Resumen de: WO2018030785A1

The present invention relates to a bimetal-conductive polymer Janus composite nanostructure having electrical stimulus response, a colloid self-assembled structure thereof, a preparing method therefor, and bio-sensing, bio-imaging, drug delivery, and industrial application using the same.



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NANOLIPOSOME CARRIER COMPOSITION CONTAINING HYBRID OF CAS9 PROTEIN AND GUIDE RNA

NºPublicación: WO2018030608A1 15/02/2018

Solicitante:
MOOGENE MEDI CO LTD [KR]

Resumen de: WO2018030608A1

The present invention relates to a nanoliposome carrier composition containing a hybrid of a Cas9 protein and guide RNA. More specifically, the present invention relates to a nanoliposome carrier composition in which a hybrid of a Cas9 protein and guide RNA specific to target DNA is encapsulated. The nanoliposome carrier composition has an excellent effect of inhibiting the expression of target DNA, and thus a pharmaceutical composition containing the nanoliposome carrier composition can be readily usable as a pharmaceutical composition enabling the alleviation or treatment of diseases such as diabetes.



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CYCLIC CARBONATE MONOMER CONTAINING DOUBLE IODINE, BIODEGRADABLE POLYMER PREPARED THEREBY AND USE

NºPublicación: US2018044315A1 15/02/2018

Solicitante:
UNIV SOOCHOW [CN]

Resumen de: US2018044315A1

The disclosure relates to a cyclic carbonate monomer containing double iodine, a biodegradable polymer prepared thereby and use. The polymer can be obtained by ring-opening polymerization of the cyclic carbonate monomer containing double iodine, without affecting the ring-opening polymerization and without a protection and deprotection process. The polymer which is obtained by ring-opening polymerization of the cyclic carbonate monomer of the present disclosure can be assembled into a nano-vesicle and a micelle as a drug carrier, a biological tissue scaffold or a CT contrast media.



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PLATINUM PRODRUGS AND METHODS OF MAKING AND USING THEREOF

NºPublicación: US2018044362A1 15/02/2018

Solicitante:
UNIV OF GEORGIA RESEARCH FOUNDATION INC [US]

Resumen de: US2018044362A1

Disclosed herein are prodrugs of platinum containing anticancer agents such as cisplatin that contain an alkylating moiety. Upon administration, the prodrugs release the platinum containing anticancer agent and the alkylating agent, which can form an adduct with DNA or can protect the platinum containing agent from removal. The disclosed prodrugs can be used to treat various cancers, including cisplatin resistant cancers.



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AMPHIPATHIC PEPTIDE

NºPublicación: US2018043031A1 15/02/2018

Solicitante:
THE QUEENS UNIV OF BELFAST [GB]

Resumen de: US2018043031A1

The present invention is directed to an amphipathic peptide and methods of using the amphipathic peptide for delivering small molecule agents to a cell. Ideally, the amphipathic cell penetrating peptide comprises less than approximately 50 amino acid residues with at least 6 arginine residues, at least 12 Alanine Residues, at least 6 leucine residues, optionally at least one cysteine residue, and at least two but no greater than three glutamic acids wherein the arginine residues are evenly distributed along the length of the peptide; and the peptide has a defined ratio of arginine to negatively charged amino acid residues and a defined ratio of hydrophilic amino acid residues to hydrophobic amino acid residues. The present invention is also directed to a nanoparticle and cell delivery system comprising the amphipathic cell penetrating peptide of the invention. The peptide, nanoparticle or cell delivery system of the invention may be used in therapy. For example, the peptide may be used as a therapeutic agent delivery system, in which the therapeutic agent may include nucleic acids or other small molecules.



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Magnetic Filtration Devices and Methods Related Thereto

NºPublicación: US2018043083A1 15/02/2018

Solicitante:
UNIV CALIFORNIA [US]

Resumen de: US2018043083A1

In vivo and ex vivo positionable magnetic filtration devices are provided that magnetically filter one or more therapeutic agents conjugated to a magnetic particle in blood flowing in a blood vessel.



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Multimodal Antimicrobial Therapy

NºPublicación: US2018042999A1 15/02/2018

Solicitante:
LONGHORN VACCINES & DIAGNOSTICS LLC [US]

Resumen de: US2018042999A1

The present invention is directed to compositions and methods for preventing and/or treating diseases and disorders of patients caused by non-Staphylococcal microorganisms. In particular, compositions and methods contain lysostaphin, altered forms of lysostaphin as compared to wild-type, and synergistic combinations of lysostaphin plus additional conventional treatments such as other enzyme, antibiotic and/or antibody treatment. The invention is also directed to detecting and identifying altered forms of lysostaphin that possess increased efficacy against infections as compared to wild-type lysostaphin, and forms that generate a minimal or no immune response in a patient. The invention is also directed to method of manufacturing lysostaphin and altered forms of lysostaphin, and compositions that direct the lysostaphin to the site of the infection such as aerosolized nanoparticles.



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PHARMACEUTICAL COMPOSITIONS

NºPublicación: US2018042906A1 15/02/2018

Solicitante:
XSPRAY MICROPARTICLES AB [SE]

Resumen de: US2018042906A1

The present invention relates to the field of methods for providing pharmaceutical compositions comprising poorly water-soluble drugs. In particular the present invention relates to compositions comprising stable, amorphous hybrid nanoparticles, comprising at least one protein kinase inhibitor and at least one polymeric stabilizing and matrix-forming component, useful in pharmaceutical compositions and in therapy.



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Multifunctional formulation comprised of natural ingredients and method of preparation/manufacturing thereof

NºPublicación: US2018042980A1 15/02/2018

Solicitante:
DATT MEDIPRODUCTS LTD [IN]
DATT LIFE SCIENCE PVT LTD [IN]

Resumen de: US2018042980A1

This invention relates to a pharmaceutical preparation for the treatment of compromised tissue such as skin wounds and ulcers in humans and animals and a method of preparation. This is a multifunctional natural matrix meant for the treatment of compromised tissues which also relates to the anti-cancer transdermal patch for melanoma therapy. Further, the invention comprises for the treatment of Alzheimer's, and multiple sclerosis also. The composition consists of water-solubilized nano-sized formulation of non-aqueous solvent extract of phyto-pharmaceuticals in herbal, animal or synthetic biocompatible gel or on matrix coated or both. The composition is used as a topical device for the treatment of compromised tissues in its preferred embodiment.



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DOSE SELECTION OF ADJUVANTED SYNTHETIC NANOCARRIERS

NºPublicación: US2018043023A1 15/02/2018

Solicitante:
ILYINSKII PETR [US]
LIPFORD GRAYSON B [US]
ZEPP CHARLES [US]
SELECTA BIOSCIENCES INC [US]

Resumen de: US2018043023A1

Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.



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METHOD FOR PRODUCING A PHARMACEUTICAL COMPOSITION OF POLYMERIC NANOPARTICLES FOR TREATING NEUROPATHIC PAIN CAUSED BY PERIPHERAL NERVE COMPRESSION

NºPublicación: US2018042860A1 15/02/2018

Solicitante:
UNIV SEVILLA [ES]
UNIV DE C\u00C1DIZ [ES]
CENTRO DE INVESTIGACI\u00D3N BIOMEDICA EN RED CIBER [ES]

Resumen de: US2018042860A1

The object of the present invention is the method for obtaining a pharmaceutical composition of polymeric nanoparticles for the treatment of neuropathic pain caused by peripheral nerve compression, related to the pharmaceutical industry and nanotechnology. The invention particularly relates to a novel system for orally administering the cannabinoid drug CB13 based on polymeric nanoparticles capable of alleviating pain for nine days following a single oral administration of an aqueous suspension of nanoparticles.



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BACTERIALLY DERIVED, INTACT MINICELLS FOR DELIVERY OF THERAPEUTIC AGENTS TO BRAIN TUMORS

NºPublicación: US2018043027A1 15/02/2018

Solicitante:
ENGENEIC MOLECULAR DELIVERY PTY LTD [AU]

Resumen de: US2018043027A1

Systemic administration of intact, bacterially derived minicells results in rapid accumulation of the minicells in the microenvironment of a brain tumor, in therapeutically significant concentrations, without requiring endothelial endocytosis/transcytosis across the blood brain barrier or any other mechanism by which, pursuant to conventional approaches, nanoparticles have entered into that microenvironment. Accordingly, a wide variety of brain tumors, both primary and metastatic, can be treated by administering systemically a therapeutically effective amount of a composition comprised of a plurality of such minicells, each minicell being a vehicle for an active agent against the tumor, such as a radionuclide, a functional nucleic acid or a plasmid encoding one, or a chemotherapeutic agent.



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TUMOR SPECIFIC ANTIBODY CONJUGATES AND USES THEREFOR

NºPublicación: US2018043038A1 15/02/2018

Solicitante:
UNIV NORTH CAROLINA CHARLOTTE [US]

Resumen de: US2018043038A1

Provided are isolated antibodies, and fragments and derivatives thereof, which bind to tumor antigens. Provided are antibody/nanoparticle conjugates. Also provided are compositions and delivery agents that include the disclosed antibodies, conjugates, fragments and derivatives thereof; cells that produce the same; methods for producing the same; methods of using the same for detecting, targeting, and/or treating tumors and/or metastatic cells derived therefrom and/or tumor stem cells; and methods for predicting the recurrence of cancer in a subject.



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PRODUCTION METHOD FOR POLY(AMINO ACID)

NºPublicación: US2018044472A1 15/02/2018

Solicitante:
TAKEDA PHARMACEUTICALS CO [JP]

Resumen de: US2018044472A1

The present invention relates to a graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof (e.g., a graft copolymer (γ-PGA-PAE) of poly(γ-glutamic acid) (γ-PGA) and phenylalanine ethyl ester (PAE)), an ionized graft copolymer of a poly(amino acid) or a salt thereof and a hydrophobic primary amine compound or a salt thereof, nanoparticles containing the ionized graft copolymer, and a production method thereof. The nanoparticles acquired in this way are useful as an adjuvant for producing a vaccine.



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CATIONIC CaMKII INHIBITING NANOPARTICLES FOR THE TREATMENT OF ALLERGIC ASTHMA

NºPublicación: WO2018031771A1 15/02/2018

Solicitante:
UNIV OF IOWA RESEARCH FOUNDATION [US]
SALEM ALIASGER K [US]
GRUMBACH ISABELLA [US]
THORN ANGIE SUE [US]
PASCHKE JOHN DARYL [US]
SEBAG SARA CAROLYN [US]

Resumen de: WO2018031771A1

A population of degradable nanoparticles comprising a coat of mucoadhesive is provided, which optionally comprise a diagnostic or therapeutic agent, as well as methods of using the nanoparticles.



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SHAPE MEMORY PARTICLES FOR BIOMEDICAL USES

NºPublicación: EP3280761A1 14/02/2018

Solicitante:
UNIV JOHNS HOPKINS [US]

Resumen de: WO2016164458A1

The presently disclosed subject matter provides compositions, methods, and kits comprising shape memory particles that can be used for delivering a drug and/or treating a disease or disorder in a patient. Specifically, shape changes in the presently disclosed shape memory particles can be used to control drug delivery spatially and/or temporally in a patient. Also provided are compositions, methods, and kits comprising nanoparticles and hypoxia-inducible factor (HIF) inhibitors for inhibiting HIF activity in a patient and/or treating a hypoxia-associated disease or disorder.



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NANOPARTICLE-BASED ANTIGEN SPECIFIC IMMUNOTHERAPY

NºPublicación: EP3280456A1 14/02/2018

Solicitante:
MIDATECH LTD [GB]
UNIV COLLEGE CARDIFF CONSULTANTS LIMITED [GB]

Resumen de: WO2016162495A1

The present invention provides a nano particle comprising: a core comprising metal atoms; a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprises: at least one carbohydrate ligand; at least one glutathione ligand; and at least one autoantigen peptide ligand. Also provided are compositions and vaccines comprising the nanoparticles, methods for producing the nanoparticles and medical uses of the nanoparticles, including for antigen specific immunotherapy of an autoimmune disease, such as diabetes mellitus type 1, in a mammalian subject.



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ENCAPSULATED NANOCOMPOSITIONS FOR INCREASING HYDROCARBON RECOVERY

NºPublicación: EP3280779A1 14/02/2018

Solicitante:
SAUDI ARABIAN OIL CO [SA]

Resumen de: WO2016164773A1

A method for increasing production in a liquid hydrocarbon reservoir formation comprising the steps of introducing a nanoencapsulated composition solution capable of reducing the #5164166.1 surface tension of a liquid hydrocarbon fraction, where the nanoencapsulated composition solution comprises a nanocapsule and a carrier fluid, such that the nanocapsule is dispersed in the carrier fluid; allowing the nanoencapsulated composition solution to interact with the liquid hydrocarbon fraction such that the surface tension of the liquid hydrocarbon fraction is reduced such that at least a portion of the liquid hydrocarbon fraction is capable of being displaced; introducing a water fraction into the wellbore under conditions such that at least a portion of the liquid hydrocarbon fraction is displaced from the liquid hydrocarbon reservoir formation; and recovering the at least a portion of the liquid hydrocarbon fraction and at least a portion of the nanoencapsulated composition solution using the wellbore.



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PROCESS FOR PREPARING A POWDER COMPRISING A HUMAN COAGULATION FACTOR PROTEIN AND A LACTIC ACID POLYMER

NºPublicación: CN107690333A 13/02/2018

Resumen de: WO2016198351A1

The invention refers to a process for preparing a powder comprising one or more human coagulation factor proteins and a lactic acid polymer, comprising the steps of a) mixing and dispersing a lactic acid polymer with a particle size d50 in the range 0.1 -2 µm and the one or more human coagulation factor proteins in water, b) drying the dispersion, c) compressing the dried mass from the dispersion, d) comminuting the compressed dried mass from the dispersion to a powder with a particle size d50 in the range of more than 0.5and up to 5 µm.



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种叶酸受体靶向的载底物纳米微泡及其制备方法

Nº publicación: CN107669659A 09/02/2018

Resumen de: CN107669659A

本发明公开了种叶酸受体靶向的载底物纳米微泡,该载底物纳米微泡由核心模板和外壳构成,核心模板为CdSe/ZnS量子点‑腔肠荧光素复合物和/或腔肠荧光素;外壳为叶酸交联聚乙二醇聚乳酸羟基乙酸聚合物。本发明还公开了该载底物纳米微泡的制备方法。本发明的载底物纳米微泡具有靶向释放、延缓降解、保持CdSe/ZnS量子点‑腔肠荧光素复合物和/或腔肠荧光素在体内的活性的优点。


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