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Resultados 209 resultados LastUpdate Última actualización 17/07/2018 [16:26:00] pdf PDF




Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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FUSION PEPTIDE COMPRISING THROMBUS-TARGETING PEPTIDE, FERRITIN FRAGMENT AND THROMBOLYTIC PEPTIDE, AND USE THEREOF

NºPublicación: WO2018128412A1 12/07/2018

Solicitante:
KYUNGPOOK NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION [KR]
KOREA INST SCI & TECH [KR]

Resumen de: WO2018128412A1

The present invention relates to: a fusion peptide comprising a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide; and a use thereof and, more specifically, to: a fusion peptide in which a thrombus-targeting peptide, ferritin fragment and a thrombolytic peptide are sequentially linked; a composition for preventing or treating thrombotic disorders, containing the same as an active ingredient; a method for treating thrombotic disorders; and a therapeutic use. According to the present invention, CLT-sFt-μPn DCNC as a novel plasmin-based thrombolytic nanocage has: an effect of targeting a site at which thrombus is present; a low sensitivity to inhibitors present in the circulatory system; pharmacological activity strongly destroying both arterial and venous thrombi; and no side effects of bleeding, and thus can be very useful in developing an agent for preventing or treating thrombotic disorders.



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TARGETED DOXORUBICIN-GOLD NANOCONJUGATES FOR TUMOR THERAPY

NºPublicación: WO2018129501A1 12/07/2018

Solicitante:
THE CURATORS OF THE UNIV OF MISSOURI [US]

Resumen de: WO2018129501A1

The present disclosure provides doxorubicin-gold nanoconjugates that can be used for cancer treatment. The present disclosure provides methods of making and using the nanoconjugates.



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METHODS FOR ASSEMBLING SCAVENGING PARTICLES

NºPublicación: WO2018129188A1 12/07/2018

Solicitante:
NANOTICS LLC [US]

Resumen de: WO2018129188A1

The disclosure provides, methods for preparing scavenging particles, as well as methods for attaching capture agents to the particles.



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COMPOSITION AND METHODS OF TREATMENT

NºPublicación: US2018193281A1 12/07/2018

Solicitante:
BLUEBERRY THERAPEUTICS LTD [GB]

Resumen de: US2018193281A1

The present invention relates to a composition comprising nanoparticles formed of a polymer and terbinafine, wherein the nanoparticles comprise particles in the range of 0.5 to 5 nm and/or in the range of 150 to 250 nm. Such compositions are particularly suited, but not limited, to the treatment of fungal nail infections.



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METHOD OF SYNTHESIS OF SILICA VESICLES AND USE THEREOF

NºPublicación: US2018193278A1 12/07/2018

Solicitante:
UNIV QUEENSLAND [AU]

Resumen de: US2018193278A1

The invention relates, in part, to a method of producing silica vesicles including under controlled conditions to thereby heavily influence the morphology and characteristics of the vesicles. The vesicles are shown to be effective as delivery agents for chemical and biological agents. They are also shown to be useful in methods of treatment and as components of an immunogenic composition.



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NANOPARTICLE COMPOSITION FOR USE IN TARGETING CANCER STEM CELLS AND METHOD FOR TREATMENT OF CANCER

NºPublicación: US2018193485A1 12/07/2018

Solicitante:
UNIV CITY HONG KONG [HK]

Resumen de: US2018193485A1

There is disclosed a composition in the form of a nanoparticle. The nanoparticle composition has a diameter from 5 to 500 nanometers. The nanoparticle composition has i) a central core portion including magnetic Fe3O4 nanoparticles adapted to act as a heat source when subjected to a magnetic field and a chemotherapeutic agent configured to treat cancer tissues, ii)—a shell portion including a shell member encapsulating said core portion, and iii)—antibodies configured to target cancer stem cells and adhered to surface of said shell member. The chemotherapeutic agent is a heat shock protein inhibitor and is releasable on activation of the heat source due to the magnetic field, and the shell member is made of silica or a silica based material. Surface of the nanoparticle is modified with the antibodies capable of binding with a cluster of differentiation molecules on the cell surface of the target cancer stem cells, whereby by way of combination of specificity of the nanoparticle composition due to the antibody, thermo-therapeutic effect of the Fe3O4 nanoparticles, and release of the heat shock protein inhibitor on site at the target cancer stem cells, inhibition of the target cancer stem cells is synergistically and additionally enhanced is increased.



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NANOCONJUGATES ABLE TO CROSS THE BLOOD-BRAIN BARRIER

NºPublicación: US2018193484A1 12/07/2018

Solicitante:
UNIV NORTHWESTERN [US]

Resumen de: US2018193484A1

Polyvalent nanoconjugates address the critical challenges in therapeutic use. The single-entity, targeted therapeutic is able to cross the blood-brain barrier (BBB) and is thus effective in the treatment of central nervous system (CNS) disorders. Further, despite the tremendously high cellular uptake of nanoconjugates, they exhibit no toxicity in the cell types tested thus far. This property is critical for therapeutic agent delivery applications for reducing off-target effects.



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System And Method For Magnetically Mediated Plasma Treatment Of Cancer With Enhanced Selectivity

NºPublicación: US2018193093A1 12/07/2018

Solicitante:
UNIV GEORGE WASHINGTON [US]

Resumen de: US2018193093A1

A system and method of treating an area having cancerous cells. The system includes a plasma device to generate a plasma jet directed at the area having cancerous cells. A magnetic field generator generates a magnetic field directed at the area having cancerous cells. A controller is coupled to the plasma device and the magnetic field generator to control the plasma jet generated by the plasma device and control the magnetic field generated by the magnetic field generator.



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MICROFABRICATED NANOPORE DEVICE FOR SUSTAINED RELEASE OF THERAPEUTIC AGENT

NºPublicación: US2018193253A1 12/07/2018

Solicitante:
DELPOR INC [US]

Resumen de: US2018193253A1

A drug delivery device that includes a capsule for implantation into the body; the capsule further includes a reservoir for containing a substance such as a therapeutic agent, at least one port for allowing the substance to diffuse from or otherwise exit the reservoir, and a nanopore membrane in communication with the capsule at or near the exit port for controlling the rate of diffusion of the substance from the exit port. The device also includes an optional screen for providing structural stability to the nanopore membrane and for keeping the pores of the nanopore membrane clear. One embodiment of the drug delivery device includes an osmotic engine internal to the device for creating fluid flow through the device.



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NANOLIPOSOMAL FORMULATION FOR TARGETING INTEGRIN-LINKED KINASE (ILK) WITH SMALL-INTERFERENCE RNA AND A METHOD FOR TREATING OVARIAN CANCER

NºPublicación: US2018193267A1 12/07/2018

Solicitante:
VIVAS MEJIA PABLO E [US]

Resumen de: US2018193267A1

The invention provides a nanoliposomal formulation that targets Integrin Linked Kinase (ILK) with small-interfering RNA (siRNA) in cisplatin-resistant ovarian cancer. A reduction in cell proliferation and invasion was observed upon ILK depletion by siRNA treatment. Furthermore, an ILK-targeted siRNA-liposomal formulation reduced tumor metastasis in an ovarian cancer mouse model. SiRNA-mediated ILK silencing reduced the phosphorylation levels of AKT and GSK3β. The nanoliposomal formulation is formed by lipids and ILK-siRNA according to specific ratios.



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POROUS THERMALLY INSULATING COMPOSITIONS CONTAINING HOLLOW SPHERICAL NANOPARTICLES

NºPublicación: US2018194954A1 12/07/2018

Solicitante:
UT BATTELLE LLC [US]
UNIV OF TENNESSEE RESEARCH FOUNDATION [US]
VIRGINIA TECH [US]

Resumen de: US2018194954A1

A method of thermally insulating a surface, the method comprising applying a coating of a thermally insulating composition onto said surface, wherein said thermally insulating composition comprises: (i) hollow spherical nanoparticles having a mean particle size of less than 800 nm in diameter and a particle size distribution in which at least 90% of the hollow spherical nanoparticles have a size within ±20% of said mean particle size, and a first layer of cationic or anionic molecules attached to said surfaces of the hollow spherical nanoparticles; and (ii) a second layer of molecules of opposite charge to the first layer of molecules, wherein said second layer of molecules of opposite charge are ionically associated with said first layer of molecules, wherein the molecules in said second layer have at least eight carbon atoms.



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NOVEL FORMULATION OF MELOXICAM

NºPublicación: US2018194759A1 12/07/2018

Solicitante:
ICEUTICA PTY LTD [AU]

Resumen de: US2018194759A1

The present invention relates to methods for producing particles of meloxicam using dry milling processes as well as compositions comprising meloxicam, medicaments produced using meloxicam in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of meloxicam administered by way of said medicaments.



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PATTERNED DOSING OF IMMUNOSUPPRESSANTS COUPLED TO SYNTHETIC NANOCARRIERS

NºPublicación: US2018193482A1 12/07/2018

Solicitante:
ILYINSKII PETR [US]
SELECTA BIOSCIENCES INC [US]

Resumen de: US2018193482A1

Provided herein are methods and related compositions for administering viral vectors and synthetic nanocarriers comprising an immunosuppressant. In some embodiments, the methods and compositions provided herein achieve improved transgene expression and/or immune response reduction, such as downregulated IgM and/or IgG immune responses.



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FORMULATIONS INCLUDING SILVER NANOPARTICLES AND METHODS OF USING THE SAME

NºPublicación: US2018193239A1 12/07/2018

Solicitante:
UNIV OF SOUTH ALABAMA [US]

Resumen de: US2018193239A1

A method for reducing or inhibiting damage to skin is disclosed herein. In some embodiments, the damage is ultraviolet (UV) radiation-induced damage. In some embodiments, the method comprises applying to the skin prior to exposure to radiation damaging source, a formulation containing an effective amount of silver nanoparticles (AgNPs) A method for treating damaged skin, and formulations include AgNPs are also disclosed.



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FUSOGENIC LIPOSOME-COATED POROUS SILICON NANOPARTICLES

NºPublicación: US2018193268A1 12/07/2018

Solicitante:
UNIV CALIFORNIA [US]

Resumen de: US2018193268A1

The disclosure describes a fusogenic liposome-coated porous silicon nanoparticles for high loading efficiency of anionic payloads (small molecules, dyes, nucleic acids), and for non-endocytic delivery of hydrophilic and lipophilic payloads by membrane fusion. The liposome coating can be further modified with targeting peptides or antibodies via covalent binding chemistry between the ligands and functionalized poly(ethylene glycol). The surface moieties can be transferred to the cellular membrane surface by fusogenic uptake. The composition of the disclosure can be applied in the treatment of diseases by delivering entrapped/encapsulated payloads.



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NOVEL DIESTER AND TRIESTER BASED LOW MOLECULAR WEIGHT, BIODEGRADEABLE CATIONIC LIPIDS FOR OLIGONUCLEOTIDE DELIVERY

NºPublicación: US2018193279A1 12/07/2018

Solicitante:
SIRNA THERAPEUTICS INC [US]

Resumen de: US2018193279A1

The instant invention provides for novel cationic lipids of Formula A that can be used in combination with other lipid components such as cholesterol and PEG-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhances efficacy along with lower liver toxicity as a result of lower lipid levels in the liver. The present invention employs low molecular weight cationic lipids with one short lipid chain coupled with inclusion of hydrolysable functionality in the lipid chains to enhance the efficiency and tolerability of in vivo delivery of siRNA.



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ANISOTROPIC PARTICLES, METHODS AND USES THEREOF

NºPublicación: US2018193910A1 12/07/2018

Solicitante:
MEMORIAL SLOAN KETTERING CANCER CENTER [US]

Resumen de: US2018193910A1

The present disclosure, among other things, provides new technologies for preparation of anisotropic nanoparticle cores (e.g., anisotropic gold nanoparticle cores) and compositions thereof. Provided technologies show a number of advantages as compared with previously available options for preparing anisotropic nanoparticle cores, including, for example, that they typically utilize mild reaction conditions and, in many embodiments, only environmentally benign agents. The present invention therefore provides “green” nanoparticle technologies. Surprisingly, in many cases, the same set of reactants can be used, under modestly different conditions, to generate nanoparticle cores of different shapes. The present invention provides selection rules for reaction conditions that generate populations containing particular shapes of interest.



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COMPOSITIONS COMPRISING A DENDRIMER-RESVERATROL COMPLEX AND METHODS FOR MAKING AND USING THE SAME

NºPublicación: US2018193286A1 12/07/2018

Solicitante:
CONCORDIA UNIV [US]

Resumen de: US2018193286A1

Compositions and pharmaceutical compositions including a dendrimer-resveratrol complex and methods for making and using the compositions are described herein. Methods of treating cancer, cardiovascular disease, cardiac failure, diabetes, Alzheimer's disease, Parkinson's disease and other brain diseases, fatty liver disease, obesity, cataracts, osteoporosis, muscle wasting, sleep disorders, acoustic trauma, inflammatory disease, psoriasis, arthritis, colitis, aging, viral disease, reproductive disease, and skin conditions or disorders including administering a therapeutically effective amount of the compositions to a subject in need are also provided. The compositions may be topically applied to skin or mucous membranes.



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BEVERAGE COMPOSITION COMPRISING NANOENCAPSULATED OXYGEN

NºPublicación: US2018193260A1 12/07/2018

Solicitante:
UNIV OXFORD INNOVATION LTD [GB]

Resumen de: US2018193260A1

The invention relates to a beverage composition comprising: water; oxygen bubbles; a surfactant in an amount of between about 0.1% (v/v) and about 0.5% (v/v); one or more viscosity modifying agent(s) in an amount of between about 0.5% (v/v) and about 2.5% (v/v); and optionally citric acid in an amount of between about 0.1% (v/v) and about 0.5% (v/v). The invention further relates to compositions, methods of treatment for cancer, the composition for use in treatment of cancer, and the manufacture of the composition.



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Nanostrukturiertes Trägersystem zum Gentransport

NºPublicación: DE102017100317A1 12/07/2018

Solicitante:
FRIEDRICH SCHILLER UNIV JENA [DE]

Resumen de: DE102017100317A1

Die Erfindung betrifft ein nanostrukturiertes Trägersystem zum Gentransport, insbesondere zur Reduktion von zytotoxischen Eigenschaften aufgrund der Nutzung eines Hüllpolymers und des daraus resultierenden Transports, zur Interaktionen mit Zellmembranen während des Transports hydrophiler Bestandteile und damit verbunden der Generierung eines frühen endosomalen Austritts des Interaktionskomplexes aus dem Trägersystem.Die Aufgabe der vorliegenden Erfindung ein nanostrukturiertes Trägersystem zum Gentransport anzugeben, welches die Nachteile des Standes der Technik vermeidet und insbesondere eine Reduktion von zytotoxischen Eigenschaften aufgrund der Nutzung eines Hüllpolymers und des daraus resultierenden Transports ermöglicht, wird dadurch gelöst, ein nanostrukturiertes Trägersystem in Form eines Partikels bestehend aus einer Trägerhülle bereitgestellt wird, wobei die Trägerhülle mindestens ein oder mehrere hydrophobe Hüllpolymere, ein oder mehrere geladene Komplexierungspolymere sowie ein oder mehrere hydrophile Wirkstoffe umfasst, wobei das Komplexierungspolymer mit dem Wirkstoff interagiert.



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Immune cell-targeted particles

NºPublicación: AU2016377775A1 12/07/2018

Solicitante:
DANA FARBER CANCER INSTITUTE INC
MASSACHUSETTS INSTITUTE OF TECH

Resumen de: AU2016377775A1

The present disclosure provides particles with a polymeric core containing a pharmaceutically active agent; and an antibody fragment conjugated to the surface of the particle, wherein the antibody fragment targets an endogenous immune cell subset (



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Radio-wave responsive doped nanoparticles for image-guided therapeutics

NºPublicación: AU2016365412A1 12/07/2018

Solicitante:
AMRITA VISHWA VIDYAPEETHAM
DEPT OF BIOTECHNOLOGY
KOYAKUTTY MANZOOR
ASHOKAN ANUSHA
HARISH VIJAY
NAIR SHANTIKUMAR

Resumen de: AU2016365412A1

The invention discloses nanoparticles comprising compounds of calcium with anions such as phosphate, pyrophosphate, sulphate, silicate, carbonate, molybdate, or phosphosilicate that are doped with various ions. The nanoparticles are configured to produce heat (hyperthermia) under radio-wave (1KHz-1000GHz) exposure together with magnetism suitable for contrast imaging in MRI, X-ray absorption for computed tomography, near-infrared optical fluorescence for optical imaging, and/or radio-isotope emission for nuclear imaging or therapy. The nanoparticles can also be incorporated into micro-beads or other 3 dimensional scaffolds for image-guided (MRI, CT, NIR, nuclear) tissue regeneration, vascular or tumor embolization, and/or chemo/radio-embolization.



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PHARMACEUTICAL COMPOSITION, PROCESS FOR PRODUCING SAME, USE OF A PEPTIDE, USE OF A PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATING DISEASES ASSOCIATED WITH INTRAOCULAR HYPERTENSION OR GLAUCOMA

NºPublicación: WO2018126306A1 12/07/2018

Solicitante:
UNIAO QUIM FARMACEUTICA NACIONAL S/A [BR]

Resumen de: WO2018126306A1

The present invention describes a pharmaceutical composition of biologically active peptides, associated with a controlled-release system using cyclodextrins or derivatives thereof, liposomes and biodegradable polymers and/or mixtures of said systems for increasing bioavailability, duration and intensity of the biological effects of the peptide. Specifically, the present invention comprises a pharmaceutical composition, a process for preparing same, and the use of a peptide in said composition for preparing medication for intraocular hypertension or glaucoma. The present invention falls within the field of medical science, more specifically of preparations for medical use, and even more specifically of medicinal preparations containing peptides.



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RNA INTERFERENCE MEDIATED INHIBITION OF HEPATITIS B VIRUS (HBV) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA)

NºPublicación: US2018195071A1 12/07/2018

Solicitante:
SIRNA THERAPEUTICS INC [US]

Resumen de: US2018195071A1

The present invention relates to compounds, compositions, and methods for the study, diagnosis, and treatment of traits, diseases and conditions that respond to the modulation of HBV gene expression and/or activity, and/or modulate a HBV gene expression pathway. Specifically, the invention relates to double-stranded nucleic acid molecules including small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules that are capable of mediating or that mediate RNA interference (RNAi) against HBV gene expression.



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PATTERNED DOSING OF IMMUNOSUPPRESSANTS COUPLED TO SYNTHETIC NANOCARRIERS

Nº publicación: WO2018129268A1 12/07/2018

Solicitante:
SELECTA BIOSCIENCES INC [US]

Resumen de: WO2018129268A1

Provided herein are methods and related compositions for administering viral vectors and synthetic nanocarriers comprising an immunosuppressant. In some embodiments, the methods and compositions provided herein achieve improved transgene expression and/or immune response reduction, such as downregulated IgM and/or IgG immune responses.


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