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Resultados 239 resultados LastUpdate Última actualización 18/01/2019 [16:39:00] pdf PDF




Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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FREEZE-DRIED FORMULATIONS INCLUDING NANOPARTICLES AND METHODS OF FREEZE-DRYING

NºPublicación: WO2019014576A1 17/01/2019

Solicitante:
UNIV CHICAGO [US]

Resumen de: WO2019014576A1

Provided are freeze-dried (FD) products of biological materials that have improved stability and reduced risk of collapse. The FD products include nanoparticles that are added to formulations including the biological materials prior to freeze-drying. Also described herein are methods of freeze-drying (FD).



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SOLUBILISATE WITH CURCUMIN AND OPTIONALLY AT LEAST ONE OTHER ACTIVE SUBSTANCE

NºPublicación: WO2019011955A2 17/01/2019

Solicitante:
AQUANOVA AG [DE]

Resumen de: WO2019011955A2

In order to make available the health-promoting and healing properties of curcumin to the human or animal organism, and in combination with at least one other active substance, the invention provides a solubilisate consisting of or containing a proportion of curcumin equal to or smaller than 10% by weight, preferably equal to or smaller than 7.5% by weight, most preferably 6% by weight, and at least one emulsifier with an HIB value in a range below 18, preferably between 13 and 18, namely polysorbate 80 or polysorbate 20 or a mixture of polysorbate 20 and polysorbate 80, the average diameter of the curcumin-charged micelles ranging from 5 nm to 40 nm, preferably from 6 nm to 20 nm, most preferably from 7 nm to 10 nm, for use in particular as a food supplement and/or medicinal drug for treating and/or preventing diseases involving inflammation, cancer and other diseases.



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META-STABLE OLIGONUCLEOTIDES JUNCTIONS FOR DELIVERY OF THERAPEUTICS

NºPublicación: WO2019014656A1 17/01/2019

Solicitante:
HAN SI PING [US]
HAJ SALAH MARWA BEN [US]
SCHERER LISA [US]
GODDARD WILLIAM A III [US]
ROSSI JOHN J [US]

Resumen de: WO2019014656A1

Disclosed herein are multi-way oligonucleotide junctions for delivering one or more cargo molecules to a biological target and method of making such junctions. The oligonucleotide junctions are formed by two or more oligonucleotides and are stable outside the cell and easily dissociate inside the cell to release the cargo molecule(s). One or more cargo molecules as well as delivery ligand can be loaded to the junctions for targeted delivery. Also disclosed are nanostructures including one or more junctions attached to each other for delivering two or more cargo molecules.



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METHOD OF INCREASING EPITHELIAL PERMEABILITY USING NANOPARTICLES

NºPublicación: WO2019014559A1 17/01/2019

Solicitante:
UNIV CARNEGIE MELLON [US]

Resumen de: WO2019014559A1

Provided herein are devices and dosage forms useful in delivering macromolecular active ingredients or drugs, such as proteins, peptides and nucleic acids, through epithelial membranes, such as intestinal epithelium. Also provided are trans-epithelial drug delivery methods and methods of treatment of diabetes or insulin resistance, or to induce weight loss.



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COMPOSITIONS AND METHODS FOR TARGETED DELIVERY OF THERAPEUTIC AND/OR DIAGNOSTIC SPECIES

NºPublicación: WO2019014549A1 17/01/2019

Solicitante:
PENN STATE RES FOUND [US]

Resumen de: WO2019014549A1

In one aspect, compositions are described herein. A composition described herein comprises a nanoparticle, a therapeutic species, and a linker joining the nanoparticle to the therapeutic species. The linker joining the nanoparticle to the therapeutic species comprises a Diels-Alder cyclo-addition reaction product. Additionally, in some embodiments, the nanoparticle is a magnetic nanoparticle.



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PHARMACEUTICAL COMPOSITIONS, METHODS FOR PREPARATION USING LIPID VESICLE PARTICLES OF DEFINED SIZE, AND USES THEREOF

NºPublicación: WO2019010560A1 17/01/2019

Solicitante:
IMMMUNOVACCINE TECH INC [CA]

Resumen de: WO2019010560A1

The present disclosure relates to methods for preparing a dried preparation comprising lipids and a therapeutic agent by using lipid vesicle particles having a mean particle size of ≤ 120 nm and a polydispersity index (PDI) of ≤ 0.1. The present application also provides stable, water-free pharmaceutical compositions comprising one or more lipid-based structures having a single layer lipid assembly, at least one therapeutic agent, and a hydrophobic carrier, as well as methods of treatment, uses and kits relating thereto, such as for example for inducing an antibody and/or CTL immune response.



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BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF

NºPublicación: US2019015328A1 17/01/2019

Solicitante:
UNIV CALIFORNIA [US]

Resumen de: US2019015328A1

The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.



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Nanoparticles Containing a Taxane and their Use

NºPublicación: US2019015350A1 17/01/2019

Solicitante:
ANP TECH INC [US]
FULGENT THERAPEUTICS INC [US]

Resumen de: US2019015350A1

Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with a taxane, such as, paclitaxel and derivatives thereof, which are water insoluble or poorly water soluble. The aggregates are formed by interaction of a taxane and a homopolymer. Such aggregates improve drug solubility, stability, delivery and efficacy.



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HEPATOPROTECTIVE PARTICLES AND SYSTEMS AND METHODS OF USE THEREOF

NºPublicación: US2019015335A1 17/01/2019

Solicitante:
SOUTH DAKOTA BOARD OF REGENTS [US]

Resumen de: US2019015335A1

Compositions for targeted delivery of a protective agent to the liver, and systems and methods for administering the compositions are described. When administered prior to or in combination with one or more chemotherapeutic agents, the compositions containing the protective agent protect the liver without adversely affecting the efficacy of the chemotherapeutic agent(s). Additionally, the use of these compositions enables the administration of higher doses of the chemotherapeutic agent(s). The compositions contain particles, comprising nanoparticles, microparticles, or combinations thereof, which contain a hepatoprotective agent. The systems contain a first formulation comprising particles that contain a protective agent to the liver and a second formulation comprising a chemotherapeutic agent. The particles containing the hapatoprotective agent are short circulating particles.



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NUCLEIC ACID VACCINES

NºPublicación: US2019015501A1 17/01/2019

Solicitante:
MODERNATX INC [US]

Resumen de: US2019015501A1

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use ribonucleic acid vaccines (NAVs) comprising polynucleotide molecules encoding one or more antigens.



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ANTICANCER DRUG-CONTAINING PLANT VIRUS PARTICLES

NºPublicación: US2019015525A1 17/01/2019

Solicitante:
CASE WESTERN RESERVE UNIVERISTY [US]

Resumen de: US2019015525A1

Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.



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COMPOUNDS, COMPOSITIONS, AND METHODS FOR THE TREATMENT OF CANCERS

NºPublicación: US2019015378A1 17/01/2019

Solicitante:
PLACON THERAPEUTICS INC [US]

Resumen de: US2019015378A1

The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.



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GLUCOSE RESPONSIVE INSULIN DELIVERY COMPOSITIONS AND METHODS

NºPublicación: US2019015515A1 17/01/2019

Solicitante:
UNIV NORTH CAROLINA STATE [US]

Resumen de: US2019015515A1

Disclosed herein is a glucose-responsive insulin delivery system based on the interaction between the glucose-modified insulin and glucose transporters (GLUTs) on erythrocytes (or red blood cells, RBCs). After being conjugated with glucose, insulin can efficiently bind to RBC membranes. The binding is reversible in the setting of hyperglycemia, resulting in fast release of insulin and subsequent drop of blood glucose (BG) level in vivo. In some embodiments, the delivery vehicle can include: 1) intravenously injectable polymeric nanoparticles ( ̃100 nm in diameter) coated with RBC membrane and loaded with glucose-modified insulin and/or 2) painless microneedle (MN) patches loaded with the complex of GLUT and glucose-modified insulin.



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TOPICAL DELIVERY OF THERAPEUTIC AGENTS USING CELL-PENETRATING PEPTIDES FOR THE TREATMENT OF AGE-RELATED MACULAR DEGENERATION AND OTHER EYE DISEASES

NºPublicación: US2019015521A1 17/01/2019

Solicitante:
MACREGEN INC [US]

Resumen de: US2019015521A1

The present disclosure provides therapeutic agents for the treatment of age-related macular degeneration (AMD) and other eye disorders. One or more therapeutic agents can be used to treat any stages (including the early, intermediate and advance stages) of AMD, and any phenotypes of AMD, including geographic atrophy (including non-central GA and central GA) and neovascularization (including types 1, 2 and 3 NV). In some embodiments, the one or more therapeutic agents are or include an anti-dyslipidemic agent, an antioxidant, an anti-inflammatory agent, a complement inhibitor, a neuroprotector or an anti-angiogenic agent, or any combination thereof. In certain embodiments, the one or more therapeutic agents are or include an anti-dyslipidemic agent (e.g., an apolipoprotein mimetic or/and a statin). In some embodiments, the one or more therapeutic agents are mixed with, non-covalently associated with or covalently bonded to a cell-penetrating peptide (CPP), encapsulated in CPP-conjugated nanoparticles, micelles or liposomes, or modified (e.g., stapled, prenylated, lipidated or coupled to a small-molecule α-helix mimic) to acquire membrane-translocating ability. In certain embodiments, the one or more therapeutic agents are administered by eye drop.



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COMPOSITION FOR INHIBITING ANGIOGENESIS COMPRISING NANOPARTICLE-VITREOUS BODY-BASED PROTEIN COMPLEX AS ACTIVE INGREDIENT, AND USE THEREOF

NºPublicación: US2019015348A1 17/01/2019

Solicitante:
SEOUL NATIONAL UNIV R & DB FOUNDATION [KR]
KOREA RES INST STANDARDS & SCI [KR]

Resumen de: US2019015348A1

Provided is a nanoparticle-vitreous body-based protein complex, and more particularly, to a composition for inhibiting angiogenesis which includes the complex as an active ingredient, and a composition for preventing or treating an angiogenesis-related disease or a retinal disease. When the nanoparticle-vitreous body-based protein complex according to the subject matter is locally injected into the vitreous body, the complex exhibits significantly excellent binding strength with a vascular endothelial growth factor and thus can inhibit angiogenesis, thus being easily used to prepare a therapeutic agent for preventing, alleviating, or treating retinal and choroidal angiogenesis-related diseases.



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PREPARATION APPARATUS FOR NANOCOMPOSITE MATERIAL AND SELF-ASSEMBLY PREPARATION METHOD

NºPublicación: US2019015338A1 17/01/2019

Solicitante:
UNIV YEUNGNAM RES COOPERATION FOUNDATION [KR]

Resumen de: US2019015338A1

The present invention relates to a self-assembly preparation method of a nanocomposite material, and more particularly, relates to a self-assembly preparation method of a nanocomposite material comprising steps of: spraying a drug-containing solution onto metal aerosol nanoparticles to form a drug layer on the metal aerosol nanoparticles; and spraying a polymer-containing solution onto the metal aerosol nanoparticles, on which the drug layer is formed, to form a polymer layer on the drug layer, whereby since the method involves no liquid chemical process upon producing the metal aerosol nanoparticles, the processes are simple and can be performed even at a low temperature to suppress deformation of an organic or a drug, and the release rate of the drug, or the like can be easily controlled through metal types of metal aerosol nanoparticles, modification, and the like.



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COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO LACK OF BLOOD SUPPLY, SHOCK AND NEURONAL INJURIES

NºPublicación: US2019015327A1 17/01/2019

Solicitante:
VIVACELLE BIO INC [US]

Resumen de: US2019015327A1

A pharmaceutical composition comprising a lipid component, an amphiphilic emulsifier, a polar liquid carrier, and one or more electrolytes, where the amphiphilic emulsifier forms lipid carrying micelles or liposomes having a lipophilic core comprising the lipid component in the polar liquid carrier, and the micelles or liposomes have an average diameter between 90 nm and 120 nm and are stable for at least 4 weeks at room temperature. The pharmaceutical composition is free of hemoglobin and fluorocarbon and can be used for treating conditions related to lack of blood supply including but not limited to restoring normal cardiac rhythm after cardiac arrest or arrhythmia and to raise the blood pressure and correct hypovolemia.



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Multifunctional Nanoparticles For Prevention And Treatment Of Atherosclerosis

NºPublicación: US2019015351A1 17/01/2019

Solicitante:
UNIV DREXEL [US]

Resumen de: US2019015351A1

This disclosure relates to nanoparticles for preventing, treating and reversing atherosclerosis.



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HYBRID MEMBRANE-COATED NANOPARTICLE COMPOSITES AND METHODS OF MAKING AND USING THE SAME

NºPublicación: US2019015526A1 17/01/2019

Solicitante:
MACKIEWICZ MARILYN [US]

Resumen de: US2019015526A1

Disclosed herein are embodiments of nanoparticle composites that comprise covalently coupled stabilizing agent molecules that improve stability of the nanoparticle composites and allow for tight packing of lipids and/or membranes. The nanoparticle composites can further comprise inhibition inhibitors and/or lipid components that interact to form a hybrid lipid bilayer membrane around the nanoparticle core. The nanoparticle composites can be coupled to drugs, targeting moieties, and imaging moieties. The nanoparticle composites can be used for in vivo drug deliver, disease diagnosis/treatment, and imaging.



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A NANOBIOCOMPOSITE FORMULATION FOR WOUND HEALING AND A PROCESS FOR THE PREPARATION THEREOF

NºPublicación: US2019015468A1 17/01/2019

Solicitante:
COUNCIL SCIENT IND RES [IN]

Resumen de: US2019015468A1

The present invention involves the isolation of plant based CNCs from the leaves of S. cumini. For the formation of NCs, a novel greener approach using S. cumini LE as reducing agent for in situ impregnation of AgNPs as fillers into CNCs as matrix is reported. The silver nitrate solution in three different concentrations of 1 mM, 5 mM and 10 mM was used to form NCs where AgNPs have been incorporated into CNCs matrix. The CNCs and NCs were characterized using SEM, TEM, XRD, Zeta potential, FT-IR, and UV-Vis spectroscopy. NCs developed in the form of film and ointment showed strong antimicrobial activity against both gram negative and gram positive bacteria. NCs wound dressing is capable of regulating wound exudates and providing moisture to wound responsible for faster healing of acute wounds. The observations from histopathological and biochemical assays confirmed that NCs enhance healing because of lesser inflammation, rapid angiogenesis, early collagen formation and enhanced rate of reepithelization.



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MUCUS-PENETRATING BUDESONIDE NANOSUSPENSION ENEMA FOR LOCAL TREATMENT OF INFLAMMATORY BOWEL DISEASE

NºPublicación: US2019015349A1 17/01/2019

Solicitante:
UNIV JOHNS HOPKINS [US]

Resumen de: US2019015349A1

Inflammatory bowel disease (IBD) is a chronic inflammatory gastrointestinal disorder that affects more than 1 million individuals in the USA. Described herein are nanoparticle mucus penetrating formulations for administration of drugs for improved mucosal distribution and tissue penetration such as in the treatment of IBD.



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FUSION POLYPEPTIDE IN WHICH ANTI-INFLAMMATORY POLYPEPTIDE AND FERRITIN MONOMER FRAGMENT ARE BOUND AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING INFLAMMATORY DISEASES, CONTAINING SAME AS ACTIVE INGREDIENT

NºPublicación: US2019016764A1 17/01/2019

Solicitante:
KYUNGPOOK NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION [KR]
KOREA INST SCI & TECH [KR]

Resumen de: US2019016764A1

The present invention relates to: a fusion polypeptide in which an anti-inflammatory polypeptide and a ferritin monomer fragment are bound; and a pharmaceutical composition for treating inflammatory diseases, containing the same as an active ingredient and, more specifically, to: a fusion polypeptide in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a ferritin monomer fragment from which a portion of a fourth loop and a fifth helix, of a human derived ferritin monomer, are removed; and a use thereof for treating inflammatory diseases. As in the above, the fusion polypeptide, which has an amino acid sequence represented by SEQ ID NO: 1 and in which an anti-inflammatory polypeptide is fused to an N-terminus and/or a C-terminus of a fragment of a human-derived ferritin monomer, can fuse two types of anti-inflammatory polypeptides, acting through different mechanisms, into a nano cage and administer the same, and thus the fusion polypeptide can exhibit an excellent effect in the treatment of inflammatory diseases including sepsis.



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COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS

NºPublicación: US2019016669A1 17/01/2019

Solicitante:
MODERNATX INC [US]

Resumen de: US2019016669A1

The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.



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PHARMACEUTICAL FORM FOR ORAL ADMINISTRATION OF A HIGHLY CONTROLLED AND STABLE DOSE OF NANOPARTICLES OR BIOMACROMOLECULE SUSPENSIONS

NºPublicación: US2019015320A1 17/01/2019

Solicitante:
UNIV CHILE [CL]

Resumen de: US2019015320A1

The invention relates to the pharmaceutical industry, particularly to the pharmaceutical industry related to drugs comprising biomacromolecules, or biopharmaceuticals. Even more particularly, the invention relates to a pharmaceutical form comprising biomacromolecules such as lymphokines, hormones, haematopoietic factors, growth factors, antibodies, enzymes, inhibitors, vaccines, and DNA or RNA derivatives. The invention provides a pharmaceutical form comprising biomacromolecules and a method for producing same based on inkjet printing using inks formed by nanosystems comprising the biomacromolecule(s), the drug or biopharmaceutical being administered orally. Even more particularly, the invention relates to a pharmaceutical form for oral administration of a highly controlled, stable controlled release dose of a biomacromolecule comprising: a) a polymer film as a printing substrate, formed by at least one pharmaceutically acceptable excipient; and b) an inkjet ink printed on the polymer film and comprising nanoparticles or nanoparticle suspensions comprising the biomacromolecule and at least one pharmaceutically acceptable excipient.



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MODIFIED STARCH

Nº publicación: WO2019014121A1 17/01/2019

Solicitante:
CORN PRODUCTS DEV INC [US]
INGREDION GERMANY GMBH [DE]
HEINZE FRIEDRICH [DE]
HIERNEIS JUSTUS [DE]

Resumen de: WO2019014121A1

Described herein is an octenyl succinic acid modified starch (OSA modified starch) degraded by at least one enzyme capable of cleaving 1,4-linkages of a starch molecule from the non-reducing ends to produce short chain saccharides, wherein the content of non-covalently bound, free octenyl succinic acid in the OSA modified starch is less than about 0.50% by weight, based on total weight of the modified starch, and wherein content of alpha-l,6-glycosidic linkages is higher than 12%, a method of preparing same, and an encapsulation agent comprising same as well as a method of encapsulating an active agent with said encapsulation agent.


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