NEOPLASIAS HEMATOLÓGICAS: LEUCEMIAS, LINFOMAS Y MIELOMAS

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Solicitudes de Patente publicadas en los últimos 30 días / Patent Applications published in the last 30 days



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NOVEL CHIMERA GENE ATF7IP-PDGFRB FOR ACUTE LYMPHOBLASTIC LEUKEMIA

Nº publicación: EP3072964A1 28/09/2016

Solicitantes:
NAT CT FOR CHILD HEALTH AND DEV [JP]
NAT CANCER CT [JP]
LSIP LLC [JP]

Resumen de: WO2015076213A1

The present invention addresses the problem of: identifying a mutation that can serve as an indicator for predicting the efficacy of treatment using a drug in a cancer such as leukemia; providing a means for detecting said mutation; providing a means for identifying, on the basis of said mutation, cancer patients or subjects at risk of cancer in whom a drug that targets a gene having said mutation or a protein coded by same will produce therapeutic effects; etc. A method for detecting a gene fusion, which is the mutation responsible for a cancer (driver mutation), the method comprising a step for detecting ATF7IP-PDGFRB fused polynucleotide or a polypeptide coded by same in an isolated sample derived from a subject.



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The medical use of 3-aryl substituted 1-indanones

Nº publicación: EP3072511A1 28/09/2016

Solicitante:
CT BADAN MOLEKULAR I MAKRO [PL]

Resumen de: EP3072511A1

The invention relates to the medical use of 3-aryl-1-indanones for the production of medicaments used in the anti-cancer therapies, acting selectively, against cancer cells of cervical cancer HeLa or cancer cells of chronic myelogenous leukemia K562.



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COMPOSITIONS AND METHODS FOR THE TREATMENT OF ACUTE MYELOID LEUKEMIAS AND MYELODYSPLASTIC SYNDROMES

Nº publicación: US2016272720A1 22/09/2016

Solicitante:
MEMORIAL SLOAN-KETTERING CANCER CENTER [US]

Resumen de: WO2015069935A1

Provided are compositions and methods for the treatment of hematological conditions, in particular CD99+ acute myelogenous leukemias (AML) and myelodysplastic syndromes (MDS), which comprise one or more antibody that (a) binds to the extracellular domain of CD99, (b) ligates AML and/or MDS cell-surface expressed CD99, (c) promotes the capping/clustering/aggregation AML and/or MDS cell-surface expressed CD99, and (d) induces apoptosis in and consequent cytotoxicity of antibody-ligated CD99+ AML and/or MDS cells. Disclosed methods include methods for identifying AML and MDS patients that are susceptible to treatment with an anti-CD99 antibody by detecting the elevated expression of CD99 in a tissue sample or cell from an AML or MDS patient and for treating an AML and/or MDS patient exhibiting elevated CD99 gene and or cell-surface protein expression by administering a composition comprising an anti-CD99 antibody, either alone or in combination with one or more additional component such as a mobilizing agent, a transmigration blocking agent, and an AML and/or MDS chemotherapeutic agent, such as daunorubicin, idarubicin, cytarabine, 5-azacytidine, and decitabine.



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METHODS OF TREATING MULTIPLE MYELOMA AND RESISTANT CANCERS

Nº publicación: US2016271133A1 22/09/2016

Solicitante:
PROLEXYS PHARMACEUTICALS INC [US]

Resumen de: WO2009002553A1

Erastin analogs are useful in treating various cancers, particularly multiple multiple myeloma. Erastin analogs are also useful in treating cancers that are resistant to other anticancer agents.



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INHIBITORS OF HISTONE DEACETYLASE

Nº publicación: US2016272579A1 22/09/2016

Solicitantes:
DANA-FARBER CANCER INST INC [US]
THE GENERAL HOSPITAL CORP [US]

Resumen de: WO2015069693A1

The present invention relates to compounds which inhibit histone deacetylase activity and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing these compounds. The present invention also relates to methods of treating and preventing hematological cell proliferative disorders, such as multiple myeloma, by administering these compounds and pharmaceutical compositions to subjects in need thereof.



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NANOPARTICLES COMPRISING A STABILIZED BORONIC ACID COMPOUND

Nº publicación: WO2016146516A1 22/09/2016

Solicitante:
LEON-NANODRUGS GMBH [DE]

Resumen de: WO2016146516A1

The present invention provides nanoparticles comprising at least one boronic acid compound and at least one stabilizing agent for the at least one boronic acid compound and/or a reaction product of the at least one boronic acid compound and the at least one stabilizing agent, whereby the nanoparticles have a particle size of about 10 to about 1000 nm. The present invention also provides a pharmaceutical composition comprising these nanoparticles and a method for the preparation of these nanoparticlesand the respective pharmaceutical compositions.In addition, the present invention provides nanoparticles and pharmaceutical compositions for the treatment of several disorders, especially multiple myeloma, preferably by parenteral administration.



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COMPOSITIONS AND METHODS FOR TARGETING CD99 IN HAEMATOPOIETIC AND LYMPHOID MALIGNANCIES

Nº publicación: WO2016149682A2 22/09/2016

Solicitante:
MEMORIAL SLOAN-KETTERING CANCER CENTER [US]

Resumen de: WO2016149682A2

Provided are compositions and methods for the treatment of hematological conditions, in particular haematopoietic and lymphoid malignancies including CD99+ acute myelogenous leukemias (AML), myelodysplasia syndromes (MDS) and T-cell neoplasms, which comprise one or more antibody that (a) binds to the extracellular domain of CD99, (b) ligates myeloid or lymphoid malignant cell-surface expressed CD99, (c) promotes the capping/clustering/aggregation myeloid or lymphoid malignant cell-surface expressed CD99, and (d) induces apoptosis in and consequent cytotoxicity of antibody-ligated CD99+ myeloid or lymphoid malignant cells. Disclosed methods include methods for identifying patients afflicted with a haematopoietic or lymphoid malignancy that are susceptible to treatment with an anti- CD99 antibody by detecting the elevated expression of CD99 in a tissue sample or myeloid or lymphoid malignant cell from a patient and for treating a patient afflicted with a haematopoietic or lymphoid malignancy exhibiting elevated CD99 gene and or cell-surface protein expression by administering a composition comprising an anti-CD99 antibody, either alone or in combination with one or more additional component such as a mobilizing agent, a transmigration blocking agent, and a chemotherapeutic agent, such as daunorubicin, idarubicin, cytarabine, 5- azacytidine, and decitabine.



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THERAPEUTIC AGENT FOR MYELODYSPLASTIC SYNDROMES

Nº publicación: WO2016148081A1 22/09/2016

Solicitante:
METROPOLITAN RES CENTER FOR BLOOD DISORDERS [JP]

Resumen de: WO2016148081A1

The present invention relates to a novel means for treating myelodysplastic syndromes, aplastic anemia or acute leukemia, characterized by comprising a combination of an adrenal corticosteroid and clarithromycin. More specifically, the present invention relates to a pharmaceutical composition for treating myelodysplastic syndromes or the like, characterized by comprising a relatively low dose of prednisolone and a relatively low dose of clarithromycin which are administered in combination.



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METHODS FOR DIAGNOSING AND TREATING FOLLICULAR LYMPHOMA

Nº publicación: WO2016149542A1 22/09/2016

Solicitante:
MEMORIAL SLOAN KETTERING CANCER CENTER [US]

Resumen de: WO2016149542A1

The invention relates generally to methods for diagnosis and treatment of follicular lymphoma or diffuse large B cell lymphoma. Specifically, the invention relates to detecting a lysine (K)-specific methyltransferase 2D (KMT2D) alteration to diagnose or treat follicular lymphoma or diffuse large B cell lymphoma.



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SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

Nº publicación: WO2016149160A1 22/09/2016

Solicitantes:
SUNSHINE LAKE PHARMA CO LTD [CN]
CALITOR SCIENCES LLC [US]

Resumen de: WO2016149160A1

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.



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METHODS FOR TREATING CANCER WITH RORgamma INHIBITORS

Nº publicación: WO2016145298A1 15/09/2016

Solicitante:
THE REGENTS OF THE UNIV OF CALIFORNIA [US]

Resumen de: WO2016145298A1

The present invention provides compositions, methods, and kits comprising one or more RORγ inhibitors, alone or in combination with one or more anticancer drugs, such as an anti-androgen drug, that are useful for treating cancer, e.g., prostate cancer, such as castration-resistant prostate cancer (CRPC), and numerous other types of cancer including lung cancer, breast cancer, liver cancer, ovarian cancer, endometrial cancer, bladder cancer, colon cancer, lymphoma, and glioma.



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FIBROBLAST GROWTH FACTOR-2 (FGF2) AND SYNDECAN-1 (SDC1) AS BIOMARKERS FOR POOR OUTCOME HODGKIN LYMPHOMA PATIENTS

Nº publicación: AU2015226976A1 15/09/2016

Solicitante:
HACKENSACK UNIVERSITY MEDICAL CT

Resumen de: US2015252433A1

The described invention comprises methods for predicting recurrence of Hodgkin Lymphoma (HL) and poor clinical outcome in a Hodgkin Lymphoma (HL) subject. The methods comprise providing a sample from the HL subject and a sample from a good clinical outcome control subject; isolating total RNA comprising Fibroblast Growth Factor-2 (FGF2) and Syndecan-1 (SDC1) RNA from the sample from the HL subject and from the sample from the good clinical outcome control subject; amplifying the total RNA; measuring a level of expression of the FGF2 and the SDC1 RNA in the HL subject and in the good clinical outcome control subject; and comparing the level of expression of the FGF2 and the SDC1 RNA expressed by the HL subject with the level of expression of the FGF2 and the SDC1 RNA expressed by the good clinical outcome control subject. An increased level of expression of the FGF2 RNA and the SDC1 RNA expressed by the HL subject compared to the level of expression of the FGF2 RNA and the SDC1 RNA expressed by the good clinical outcome control subject is indicative of recurrence of HL or poor clinical outcome for the HL subject. The described invention further comprises a method of detecting evidence of metastatic Hodgkin lymphoma in a Hodgkin Lymphoma (HL) subject by measuring an increased level of expression of CD30, FGF2 and SDC1 RNA in an HL subject compared to a good clinical outcome control subject.



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MARKERS FOR MLL-REARRANGED ACUTE MYELOID LEUKEMIAS AND USES THEREOF

Nº publicación: WO2016141492A1 15/09/2016

Solicitantes:
UNIVERSIT\u00C9 DE MONTR\u00C9AL [CA]
RSEM LTD PARTNERSHIP [CA]

Resumen de: WO2016141492A1

Genes exhibiting specific mutational and/or transcriptional patterns in mixed-lineage leukemia- rearranged acute myeloid leukemia (MLL leukemia) relative to other types of AMLs are disclosed. The use of these mutational and/or transcriptional patterns for the diagnosis, prognosis, characterization and/or treatment of MLL leukemia is also disclosed.



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GENETICALLY ENGINEERED HOST CELLS FOR MALARIA RESEARCH

Nº publicación: WO2016144642A1 15/09/2016

Solicitante:
CHROMOLOGIC LLC [US]

Resumen de: WO2016144642A1

In some embodiments of the present invention, an erythroleukemic cell includes exogenous expression of at least one selected from the group consisting of Duffy antigen receptor chemokine (DARC), glycophorin A (GlyA), basigin, beta-globin, alpha-globin, and B-cell lymphoma/leukemia 11A (BCL11A). In some embodiments of the present invention, a cell culture includes an erythroleukemic cell, including exogenous or endogenous expression of at least one selected from the group consisting of Ourfy antigen receptor chemokine (DARC), glycophorin A (GlyA), basigin, beta-globin, alpha-globin, and B-cell lymphoma/leukemia 11A (BCL11A); and hemin. In some embodiments, the cell culture also includes JQ1 and TGFβ1. In some embodiments of the present invention, a method of inducing hemoglobinization and differentiation in an erythroleukemic cell.



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SECURININE AND NORSECURININE ANALOGUE COMPOUNDS FOR THE TREATMENT OF MYELOID DISORDERS

Nº publicación: US2016263089A1 15/09/2016

Solicitante:
UNIV CASE WESTERN RESERVE [US]

Resumen de: US2016263089A1

The present application relates to securinine or norsecurinine analogues that, when administered to immature myeloid cells, promote differentiation of these cells to mature cells that do not readily proliferate. Therefore, the agents are useful in the treatment of myeloid disorders including myeloproliferative disorders, acute myeloid leukemia, and autoimmune diseases. The agents may also be used as a myeloablative agent in conjunction with a bone marrow transplant or stem cell therapy.



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METHODS FOR TREATMENT OF FOLLICULAR LYMPHOMA USING 3-(4-AMINO-1-OXO-1,3-DIHYDROISOINDOL-2-YL)-PIPERIDINE-2,6-DIONE

Nº publicación: US2016263095A1 15/09/2016

Solicitante:
CELGENE CORP [US]

Resumen de: US2010196369A1

Methods of treating, preventing and/or managing cancer as well as and diseases and disorders associated with, or characterized by, undesired angiogenesis are disclosed. Specific methods encompass the administration of an immunomodulatory compound alone or in combination with a second active ingredient. The invention further relates to methods of reducing or avoiding adverse side effects associated with chemotherapy, radiation therapy, hormonal therapy, biological therapy or immunotherapy which comprise the administration of an immunomodulatory compound. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.



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PLATFORM DRUG DELIVERY SYSTEM UTILIZING CRYSTAL ENGINEERING AND THEANINE DISSOLUTION

Nº publicación: US2016263138A1 15/09/2016

Solicitante:
THEAPRIN PHARMACEUTICALS INC [US]

Resumen de: WO2016144590A1

A platform drug delivery system and a method of improving the delivery of low solubility pharmaceuticals utilizing crystal engineering and Theanine dissolution resulting in enhanced bioactivity, dissolution rate, and solid state stability.



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TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO MATRIPTASE ANTIBODIES

Nº publicación: US2016263244A1 15/09/2016

Solicitantes:
RUTGERS THE STATE UNIV OF NEW JERSEY [US]
UNIV GEORGETOWN [US]

Resumen de: US2016263244A1

The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase. In addition, administration of a matriptase antibody or immunoconjugates of a matriptase antibody and a cytotoxic agent in combination with administration of an immunomodulatory agent, such as thalidomide or an analog thereof, provides a more effective treatment of these cancers.



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RONEPARSTAT COMBINED THERAPY OF MULTIPLE MYELOMA

Nº publicación: WO2016142814A1 15/09/2016

Solicitantes:
SIGMA-TAU RES SWITZERLAND S A [CH]
THE UAB RES FOUND [US]

Resumen de: WO2016142814A1

The present invention relates to roneparstat for use in a combined therapy for the treatment of multiple myeloma. In particular it has unexpectedly been found that the combined use of roneparstat with a proteasome inhibitor, in particular selected between bortezomib and carfilzomib or with melphalan improve efficacy in decreasing the overall tumor burden, especially showing synergism, with respect to the administration of each active ingredient alone.



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METHODS OF TREATING MYELOID LEUKEMIA

Nº publicación: HK1215790A1 15/09/2016

Solicitante:
BIOKINE THERAPEUTICS LTD [IL]

Resumen de: WO2014155376A1

There is provided a method of treating a myeloid leukemia. The method includes the step of administering to a subject in need thereof a therapeutically effective amount of a CXCR4-antagonistic peptide and a therapeutically effective amount of a chemotherapeutic agent.



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THERAPEUTIC AGENT FOR INTRACTABLE LEUKEMIA

Nº publicación: WO2016143896A1 15/09/2016

Solicitante:
RIKEN [JP]

Resumen de: WO2016143896A1

The present invention provides a therapeutic composition for intractable leukemia which comprises a drug (a) and a drug (b), wherein the drug (a) is a compound represented by formula (I) (wherein Ar1 represents a substituted or unsubstituted arylene group; Ar2 represents a substituted or unsubstituted aryl group or a substituted or unsubstituted aralkyl group; L represents an oxygen atom, -NHCO- or -CONH-; X1 represents CH; X2 and X3 represent CH and a nitrogen atom, respectively; Y represents an ethylene group; m represents 0; and Z1 and Z2 include X3 and independently represent a substituted or unsubstituted monocyclic heterocyclic group containing two nitrogen atoms as members of the ring), a salt of the compound, or a prodrug of the compound or the salt, and the drug (b) is a steroid-type anti-inflammatory drug. Therefore, the present invention relates to a therapeutic agent for intractable leukemia.



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INDOLOQUINOLONE COMPOUNDS AS ANAPLASTIC LYMPHOMA KINASE (ALK) INHIBITORS

Nº publicación: AU2014384476A1 15/09/2016

Solicitante:
JIANGSU ASCENTAGE BIOMED DEV INC

Resumen de: WO2015127629A1

Disclosed herein are certain indoloquinolone compounds, methods of preparation thereof, pharmaceutical compositions thereof, and uses thereof, such as their uses as ALK inhibitors



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TREATING MYELOMAS

Nº publicación: US2016263241A1 15/09/2016

Solicitante:
MAYO FOUND FOR MEDICAL EDUCATION AND RES [US]

Resumen de: WO2015195476A1

This document provides methods and materials related to treating myelomas. For example, methods and materials relating to the use of a composition containing albumin-containing nanoparticle/antibody complexes (e.g., ABRAXANE®/anti-CD38 polypeptide antibody complexes) to treat myelomas are provided.



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PYRROLO PYRIMIDINE DERIVATIVE

Nº publicación: US2016264579A1 15/09/2016

Solicitante:
ONO PHARMACEUTICAL CO [JP]

Resumen de: EP3067356A1

The compound represented by general formula (I) has strong Axl inhibition activity by means of a pyridone ring structure being introduced into a pyrrolo pyrimidine skeleton, and so the result can serve as a treatment agent for Axl-related diseases, for example cancers such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glial tumors, renal disease, immune system disorders, and cardiovascular disease.



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COMBINATION OF ANTI-KIR AND ANTI-CS1 ANTIBODIES TO TREAT MULTIPLE MYELOMA

Nº publicación: EP3066128A1 14/09/2016

Solicitantes:
SQUIBB BRISTOL MYERS CO [US]
INNATE PHARMA [FR]

Resumen de: WO2015069785A1

Provided are methods for clinical treatment of multiple myeloma using an anti- KIR antibody in combination with an anti-CS 1 antibody.


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