NEOPLASIAS HEMATOLÓGICAS: LEUCEMIAS, LINFOMAS Y MIELOMAS

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Solicitudes de Patente publicadas en los últimos 30 días / Patent Applications published in the last 30 days



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Antibody recognising human leukemia inhibitory factor (LIF) and use of anti-LIF antibodies in the treatment of diseases associated with unwanted cell proliferation

Nº publicación: EP3045473A1 20/07/2016

Solicitantes:
FUNDACIO PRIVADA INST D INVESTIGACIO ONCOLOGICA DE VALL D HEBRON VHIO [ES]
FUNDACI\u00D3 PRIVADA INSTITUCI\u00D3 CATALANA DE RECERCA I ESTUDIS AVAN\u00C7ATS [ES]

Resumen de: EP2371860A1

The invention relates to antibodies directed against human Leukemia Inhibitory Factor (LIF) and to a hybridoma cell line producing said antibodies. The invention also relates to a method for blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of a subject suffering from said disease. The therapeutic potential of said antibodies is based on observing that the inhibition of LIF can be used in therapeutic compositions for the treatment of diseases associated with unwanted proliferation.



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Heterocyclic compounds and their uses

Nº publicación: EP3045458A1 20/07/2016

Solicitante:
AMGEN INC [US]

Resumen de: US2009137581A1

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110delta activity, including but not restricted to leukemias,; such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia (T-ALL) B-cell Acute Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphoma and solid tumors, such as breast cancer.



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COMBINATION OF EPIGENETIC FACTORS AND BISPECIFIC COMPOUNDS TARGETING CD33 AND CD3 IN THE TREATMENT OF MYELOID LEUKEMIA

Nº publicación: EP3043794A2 20/07/2016

Solicitantes:
AMGEN INC [US]
AMGEN RES MUNICH GMBH [DE]

Resumen de: WO2015036583A2

The present invention provides a combination epigenetic factors and bispecific compounds targeting CD33 and CD3 in the treatment of myeloid leukemia, wherein the epigenetic factor is selected from the group consisting of histone deacetylase (HDAC) inhibitors, DNA methyltransferase (DNMT) I inhibitors,hydroxyurea, Granulocyte-Colony Stimulating Factor (G-CSF), histone demethylase inhibitors and ATRA (All Trans-retinoic acid). Accordingly, the invention provides a pharmaceutical composition comprising a CD33 targeting compound and at least one epigenetic factor and an epigenetic factor for use in the amelioration and/or treatment of a myeloid leukemia, wherein the epigenetic factor increases the responsiveness of a patient to a CD33 targeting compound.; Moreover, the invention provides the use of at least one an epigenetic factor for increasing the responsiveness of a myeloid leukemia patient to a treatment with a CD33 targeting compound, a method for the treatment of a myeloid leukemia, the method comprising the administration of at least one epigenetic factor and a CD33 targeting compound to a patient in the need thereof and a kit comprising a pharmaceutical composition of the invention or an epigenetic factor of the invention and a bispecific CD33 targeting compound.



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METHODS AND COMPOSITIONS FOR INDUCING DEREGULATION OF EPHA7 AND ERK PHOSPHORYLATION IN HUMAN ACUTE LEUKEMIAS

Nº publicación: US2016199403A1 14/07/2016

Solicitante:
UNIV OHIO STATE RES FOUND [US]

Resumen de: WO2009026487A1

Methods for assessing a pathological condition in a subject include measuring one or more markers where a difference is indicative of acute lymphoblastic leukemia (ALL) or a predisposition to ALL, uses and compositions are disclosed.



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METHODS FOR PREDICTING DRUG RESPONSIVENESS IN CANCER PATIENTS

Nº publicación: US2016199399A1 14/07/2016

Solicitante:
MEDICAL PROGNOSIS INST A S [DK]

Resumen de: US2016199399A1

The invention features methods for predicting responsiveness to chemotherapy drug(s) in cancer patients (e.g., patients with lymphoma (e.g, patients with DLBCL)), by, e.g., determining a level of expression of one or more biomarkers in a biological sample obtained from the patient.



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COMPOSITION CONTAINING MONOACETYLDIACYLGLYCEROL COMPOUND AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING ASTHMA

Nº publicación: US2016199339A1 14/07/2016

Solicitantes:
ENZYCHEM LIFESCIENCES CORP [KR]
KOREA RES INST OF BIOSCIENCE [KR]
KOREA RES INST OF BIO SCIENCE AND BIOTECHNOLOGY [KR]

Resumen de: WO2015026124A1

The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating asthma, and a functional health food composition for preventing or treating asthma. The monoacetyldiacylglycerol compound of the present invention inhibits the expression of IL-4 in EL-4 cells, which are mouse T cell lymphoma cells, reduces hypersensitivity of airway in an asthma-induced animal model, and inhibits the infiltration of inflammatory cells into the bronchial tube. In addition, the compounds of the present invention inhibit the generation of IgE in the serum and bronchoalveolar lavage fluid, have an excellent effect of inhibiting the expression of Th2 cytokines (IL-4, IL-5, and IL-13) in the lung, thereby overcome side effects of the currently used therapeutic agents for asthma, have no toxicity, and exhibit a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating asthma.



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MULTIPLE MYELOMA TREATMENT

Nº publicación: US2016199324A1 14/07/2016

Solicitante:
VANDA PHARMACEUTICALS INC [US]

Resumen de: WO2015027125A1

The invention relates generally to the treatment of multiple myeloma. One embodiment of the invention provides a method of treating multiple myeloma (MM) in an individual, the method comprising: administering to the individual an effective amount of trichostatin A (TSA).



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Pharmaceutical compositions comprising of sodium meta-arsenite for use in the treatment of leukemia and lymphoma

Nº publicación: US2016199411A1 14/07/2016

Solicitante:
KOMINOX INC [KY]

Resumen de: EP2361628A1

The present application relates to pharmaceutical compositions and method for treatment of cancer and its metastasis in a human, which pharmaceutical compositions contains an effective amount of arsenous acid alkaline or earth alkaline metal salt and/or a pharmaceutically acceptable adjuvant. According to the present invention, the alkaline arsenous acid metal salt is sodium meta-arsenita (As0 2 Na) or potassium meta-arsnite (As0 2 K). The effective amount of arsenous acid alkaline or earth alkaline metal salt is 0.0001-1500 mg/kg, preferably 1-1000 mg/kg, more preferably 1-150 mg/kg, and most preferably 50-100 mg/kg of body weight/day. The administration form of the pharmaceutical compositions of the invention is preferably oral, such as a table, capsule, powder and/or solution with a pharmaceutically acceptable carrier, diluent or excipient.



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METHODS FOR MANIPULATING PHAGOCYTOSIS MEDIATED BY CD47

Nº publicación: US2016200816A1 14/07/2016

Solicitante:
UNIV LELAND STANFORD JUNIOR [US]

Resumen de: WO2009091601A1

Methods are provided to manipulate phagocytosis of cells, including hematopoietic cells, e.g. circulating hematopoietic cells, bone marrow cells, etc.; and solid tumor cells. In some embodiments of the invention the circulating cells are hematopoietic stem cells, or hematopoietic progenitor cells, particularly in a transplantation context, where protection from phagocytosis is desirable. In other embodiments the circulating cells are leukemia cells, particularly acute myeloid leukemia (AML), where increased phagocytosis is desirable.



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ANTI-CD38 HUMAN ANTIBODIES AND USES THEREFOR

Nº publicación: US2016200828A1 14/07/2016

Solicitante:
MORPHOSYS AG [DE]

Resumen de: CA2555185A1

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for CD38, which plays an integral role in various disorder s or conditions. These antibodies, accordingly, can be used to treat, for example, hematological malignancies such as multiple myeloma. Antibodies of the invention also can be used in the diagnostics field, as well as for investigating the role of CD38 in the progression of disorders associated wi th malignancies. The invention also provides nucleic acid sequences encoding th e foregoing antibodies, vectors containing the same, pharmaceutical compositio ns and kits with instructions for use. The invention also provides isolated nov el epitopes of CD38 and methods of use therefore.



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WT1 MUTATIONS FOR PROGNOSIS OF MYELOPROLIFERATIVE DISORDERS

Nº publicación: US2016201141A1 14/07/2016

Solicitante:
QUEST DIAGNOSTICS INVEST INC [US]

Resumen de: WO2011059835A2

The invention provides methods for determining the prognosis of a patient diagnosed with a leukemia, including B-cell chronic lymphocytic leukemia, by measuring mutations of the WT1 gene in a biological sample. The invention also relates to the diagnosis of leukemia, including B-cell chronic lymphocytic leukemia.



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(PIPERIDIN-3-YL)(NAPHTHALEN-2-YL)METHANONE DERIVATIVES AND RELATED COMPOUNDS AS INHIBITORS OF THE HISTONE DEMETHYLASE KDM2B FOR THE TREATMENT OF CANCER

Nº publicación: WO2016112284A1 14/07/2016

Solicitantes:
GENENTECH INC [US]
CONSTELLATION PHARMACEUTICALS INC [US]

Resumen de: WO2016112284A1

The present invention relates to (piperidin-3-yl)(naphthalen-2-yl) methanone derivatives and related compounds as inhibitors of one or more histone demethylses, such as KDM2b. The invention also provides pharmaceutically acceptable compositions comprising compounds of the present invention and discloses methods of using said compositions in the treatment of cancer, such as lung cancer, leukemia or lymphoma.



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MARKERS OF ACUTE MYELOID LEUKEMIA STEM CELLS

Nº publicación: EP3043181A1 13/07/2016

Solicitante:
UNIV LELAND STANFORD JUNIOR [US]

Resumen de: WO2009091547A1

Markers of acute myeloid leukemia stem cells (AMLSC) are identified. The markers are differentially expressed in comparison with normal counterpart cells, and are useful as diagnostic and therapeutic targets.



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QUINOLINE CARBOXAMIDES FOR USE IN THE TREATMENT OF MULTIPLE MYELOMA

Nº publicación: EP3041472A1 13/07/2016

Solicitante:
ACTIVE BIOTECH AB [SE]

Resumen de: WO2016042112A1

A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of multiple myeloma.



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OLIGONUCLEOTIDE MODULATORS OF B-CELL CLL/LYMPHOMA 11A (BCL11A) AND USES THEREOF

Nº publicación: HK1213595A1 08/07/2016

Solicitante:
ROCHE INNOVATION CENTER COPENHAGEN AS [DE]

Resumen de: WO2014188001A1

The present invention provides, among other things, oligonucleotide modulators (e.g., inhibitors) of B cell lymphoma/leukemia 11A (BCL11A) and improved methods and composition for treating BCL11A-related diseases, disorders or conditions based on such modulators.



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Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs

Nº publicación: US2016193320A1 07/07/2016

Solicitante:
BOEHRINGER INGELHEIM VETMED [US]

Resumen de: EP2371384A1

The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.



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Substituted 2,3-dihydroimidazo1,2-cquinazoline salts

Nº publicación: US2016193219A1 07/07/2016

Solicitante:
BAYER IP GMBH [DE]

Resumen de: CN103649091A

The present invention relates: - to 2-amino-N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydroimidazo- [1,2-c]quinazolin-5-yl]pyrimidine-5-carboxamide dihydrochloride salt of formula (II) : or a tautomer, solvate or hydrate thereof; - to methods of preparing said dihydrochloride salt; - to said dihydrochloride salt for the treatment and/or prophylaxis of a disease; - to the use of said dihydrochloride salt for the preparation of a medicament for the treatment and/or prophylaxis of a disease, in particular of a hyper- proliferative and/or angiogenesis disorder, more particularly for the treatment or prophylaxis of a cancer, particularly lung cancer, in particular non-small cell lung carcinoma, colorectal cancer, melanoma, pancreatic cancer, hepatocyte carcinoma, pancreatic cancer, hepatocyte carcinoma or breast cancer; - to a pharmaceutical composition comprising said dihydrochloride salt; and - to a pharmaceutical combination comprising said dihydrochloride salt in combination with one or more further pharmaceutical agents.



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BIOMARKERS FOR PREDICTING RESPONSIVENESS TO DECITABINE THERAPY

Nº publicación: WO2016109284A1 07/07/2016

Solicitante:
UNIV MICHIGAN [US]

Resumen de: WO2016109284A1

Provided herein is technology relating to predicting a subject's resistance or responsiveness to a decitabine based therapy and particularly, but not exclusively, to methods, compositions, and related uses for predicting a subject's resistance or responsiveness to a decitabine based therapy wherein the subject is diagnosed with chronic myelomonocytic leukemia.



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STYRYL QUINAZOLINE DERIVATIVES AS PHARMACEUTICALLY ACTIVE AGENTS

Nº publicación: US2016194291A1 07/07/2016

Solicitante:
VICHEM CHEMIE KUTAT\u00D3 KFT [HU]

Resumen de: WO2015019121A1

The present invention relates to styryl quinazoline derivatives of the general formula (I) and pharmaceutically acceptable solvates, hydrates, salts, regioisomeric and polymorphic forms thereof as well as pharmaceutical compositions containing at least one of the described compounds as pharmaceutically active agent. The compounds have been identified as new drug candidates for the prevention and/or treatment of diseases related to disfunction(s) of hematopoiesis and cancer or any other form of neo- or hyperplasias related to Fms-like tyrosine kinase 3 (FLT3) containing Internal Tandem Duplications (ITD), especially in the case of myeloid leukemia. The compounds have been also identified as new drug candidates as antibacterial agents (having bactericidal or bacteriostatic activity) which can be used for the prevention and/or treatment of bacterial infectious diseases. 1/2



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Bispecific CD33 and CD3 Binding Proteins

Nº publicación: US2016194409A1 07/07/2016

Solicitante:
AMPHIVENA THERAPEUTICS INC [US]

Resumen de: US9212225B1

Described herein are binding proteins that specifically bind to human CD33, and in particular to bispecific binding proteins that specifically bind to human CD33 and human CD3. Also described herein are bispecific tandem diabodies that bind to CD33 and CD33, and their uses for immunotherapy of CD33+ cancers, diseases and conditions such as acute myeloid leukemia (AML).



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HISTONE DEMETHYLASE INHIBITORS

Nº publicación: US2016194306A1 07/07/2016

Solicitante:
CELGENE QUANTICEL RES INC [US]

Resumen de: US2016194306A1

The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition of histone demethylase enzymes. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as pancreatic cancer, prostate cancer, breast cancer, bladder cancer, lung cancer, gastric cancer, leukemia and/or melanoma and the like.



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TRIAZOLONE COMPOUNDS AND USES THEREOF

Nº publicación: US2016194292A1 07/07/2016

Solicitante:
INCEPTION 2 INC [US]

Resumen de: WO2015035059A1

The invention disclosed herein is directed to compounds of Formula (la) and (lb) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic[delta] leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of Formula (la) or (lb), or a pharmaceutically acceptable salt thereof. The invention disclosed herein is also directed to methods of treating prostate, breast, ovarian, liver, kidney, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention disclosed herein is further directed to methods of treating prostate, breast, colon, pancreatic, chronic lymphocytic leukemia, melanoma and other cancers comprising administration of a therapeutically effective amount of a compound which is a dual antagonist of PPAR[alpha] and PPAR[delta]. The compounds and pharmaceutical compositions of the invention are also useful in the treatment of viral infections, such as HCV infections and HIV infections. The invention disclosed herein is also directed to a methods of preventing the onset of and/or recurrence of acute and chronic myeloid leukemia, as well as other cancers, comprising administration of a herapeutically effective amount of a dual antagonist of PPAR[alpha] and PPAR[delta].



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METHODS AND COMPOSITIONS FOR TREATMENT OF RETINOID-RESPONSIVE CONDITIONS

Nº publicación: US2016194381A1 07/07/2016

Solicitante:
PENN STATE RES FOUND [US]

Resumen de: WO2009108762A2

Methods and composition for treating a retinoid-responsive condition in a subject are provided according to embodiments of the present invention which include administering a therapeutically effective amount of a substance selected from the group consisting of: neutrophil gelatinase-associated lipocalin (NGAL), an NGAL analog, an NGAL stimulator and an analog of an NGAL stimulator, to a subject having a retinoid-responsive condition. Retinoid- responsive conditions illustratively include acne, rosacea, psoriasis, promyelocytic leukemia and neuroblastoma.



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Anaplastic Lymphoma Kinase (ALK) As An Oncogene Capable Of Transforming Normal Human Cells

Nº publicación: US2016194616A1 07/07/2016

Solicitante:
UNIV PENNSYLVANIA [US]

Resumen de: US2015031856A1

The present invention provides compositions and methods for transforming primary mammalian cells using an oncogenic form of ALK wherein the transformed cells display features of that of a corresponding tumor cell isolated from a cancer subject. The invention also provides a method for immortalizing normal CD4+ T lymphocytes with a lymphoma-characteristic form of ALK such as NPM-ALK.



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INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)

Nº publicación: WO2016105528A2 30/06/2016

Solicitante:
DANA FARBER CANCER INST INC [US]

Resumen de: WO2016105528A2

The present invention provides novel compounds of Formula (I), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, acute lymphoblastic leukemia, lymphoma, Burkitt's lymphoma, melanoma, multiple myeloma, breast cancer, Ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer, colorectal cancer), benign neoplasms, diseases associated with angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as a cyclin-dependent kinase (CDK) (e.g., cyclin-dependent kinase 7 (CDK7)), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.


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