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Resultados 51 resultados LastUpdate Última actualización: 23/07/2016 [21:01:00] pdf PDF




Solicitudes de Patente publicadas en los últimos 90 días / Patent Applications published in the last 90 days



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Preparation of live vaccines

Nº publicación: HK1213949A1 15/07/2016

Solicitante:
LOHMANN ANIMAL HEALTH GMBH [DE]

Resumen de: AU2013311675A1

Described is a method for the generation of a live vaccine containing stable bacteria carrying at least three attenuating mutations and a vaccine containing bacteria obtained by said method.



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SEQUENCES AND THEIR USE FOR DETECTION OF SALMONELLA ENTERITIDIS AND/OR SALMONELLA TYPHIMURIUM

Nº publicación: US2016201116A1 14/07/2016

Solicitante:
DU PONT [US]

Resumen de: WO2015026757A2

This invention relates to a rapid, accurate method for detection and characterization of Salmonella enteritidis and/or Salmonella typhimurium based on the presence of nucleic acid sequences, in particular, to a PCR-based method for detection, and to oligonucleotide molecules and reagents and kits useful therefore. This method is preferably employed to detect S. enteritidis and/or S. typhimurium in an environmental sample. The present invention further relates to replication compositions and kits for carrying out the method of the present invention.



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Salmonella and Listeria Assay Methods and Kits

Nº publicación: US2016201107A1 14/07/2016

Solicitante:
UNIV MISSISSIPPI STATE [US]

Resumen de: WO2016054282A1

Methods and kits for detection of bacteria, especially Salmonella spp. and Listeria spp., are provided using a unique combination of selective ingredients and two-phase culture (solid-phase culture gel and liquid-phase culture/enrichment broth) allows for high sensitivity and specificity of the kits for growth of Salmonella and Listeria in the detection methods and kits. The invention, through the detection mechanism accomplished by the novel formulation of selective ingredients and the two-phase culture, allows for real-time detection of a single cell of Salmonella and Listeria within 24+- 2 hours of introducing a target sample to the Salmonella and Listeria detection kits. The detection methods and kits for Salmonella may optionally further comprise a confirmation step that can increase sensitivity and accuracy for this pathogenic bacteria.



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NOVEL CYCLIC DEPSIPEPTIDE-BASED COMPOUND, METHOD FOR PREPARING SAME, AND ANTIBACTERIAL PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

Nº publicación: WO2016111574A1 14/07/2016

Solicitante:
KOREA RES INST OF BIOSCIENCE [KR]

Resumen de: WO2016111574A1

The present invention relates to a novel cyclic depsipeptide-based compound, a method for preparing same, and an antibacterial pharmaceutical composition containing same as an active ingredient, the novel cyclic depsipeptide-based compound, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, exhibiting inhibitory activity against Staphylococcus aureus and Salmonella typhimurium, thereby being able to be usefully employed for an antibacterial composition, antibacterial pharmaceutical composition, antibacterial feed composition, or antibacterial cosmetic composition, and for the treatment of bacterial infectious diseases.



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AUTOMATED ASSAY

Nº publicación: US2016195524A1 07/07/2016

Solicitante:
UNIV STRATHCLYDE [GB]

Resumen de: WO2015114316A2

Disclosed is a system and method for automating the performance of a conjugate or sandwich assay, and a cassette for use with the system. The cassette comprises a fluid conduit and one or more chambers in the fluid conduit, from which a measurement may be acquired from a sample using a cassette reader device. Sample and reagent fluids may be caused to flow along the fluid conduit to perform the assay and control over the progress of the assay may be exerted at least in part by the arrangement of chambers in the fluid conduit. Also disclosed is a tablet or bead for use with the assay system, which may be incorporated in the cassette. The tablet or bead may comprise one or more reagents to be used in the assay, in a soluble matrix. Use of an acridan or acridinium ester label may enable a sensitive measurement to be rapidly acquired.; The assay may be configured to be performed by a clinician at the point of use or care.



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DELETION MUTANTS OF FLAGELLIN AND METHODS OF USE

Nº publicación: US2016193329A1 07/07/2016

Solicitante:
VAXINNATE CORP [US]

Resumen de: WO2009128950A2

Compositions that include Toll-like Receptor 5 agonists and at least a portion of at least one influenza antigen can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can be associated with particles and employed in the methods in relatively low doses to provide protective immunity to viral infection.



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A BACTERIAL VACCINE AND METHODS FOR MANUFACTURE THEREOF

Nº publicación: CN105744951A 06/07/2016

Resumen de: WO2015029056A1

Disclosed are stable conjugate vaccine formulations for protection against Salmonella typhi, and methods of conjugation between Vi-polysaccharide of S.typhi to tetanus toxoid as the carrier protein, responsible for producing improved T-dependent immune response against Typhoid fever caused by Salmonella typhi. The methods disclosed in this invention and the resulting formulations are capable of inducing immunity against typhoid fever including in children below 2 years of age, through only a single injection to comprise a complete vaccination schedule.



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O-ANTIGEN CARBOHYDRATE CHAIN EXTENDED S ALMONELLA PARATYPHI A AND USE THEREOF

Nº publicación: CN105734001A 06/07/2016

Resumen de: WO2016090980A1

Provided are an O-antigen carbohydrate chain extended Salmonella paratyphi A and a use thereof. The method comprises the following steps: inactivating a cld geneof the enzyme for controlling the O-antigen chain length of Salmonella paratyphi A, and obtaining Salmonella paratyphi A defects in a cld gene of the enzyme for controlling the O-antigen chain length; overexpressing a cld LT2 gene of the enzyme for controlling the O-antigen chain length of Salmonella typhimurium in the Salmonella paratyphi A defects in the cld gene of the enzyme for controlling the O-antigen chain length, and then extending the O-antigen carbohydrate chain length of Salmonella paratyphi A.



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COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO ENTERIC PATHOGENS

Nº publicación: EA201591798A1 30/06/2016

Resumen de: WO2014152508A1

Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD 154 polypeptide or an HMGB1 polypeptide.



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Poultry Cleaning Knife

Nº publicación: US2016183541A1 30/06/2016

Solicitante:
ATEN MAKARE AKHET [US]

Resumen de: US2016183541A1

The main function(s) of the Poultry Cleaning knife abbreviated (PCK) is for cleaning poultry surface skins. The Poultry Cleaning Knife scrapes (by gliding) the knife blade across the surface of poultry skin in a downward, continuous, stroking motion. Main parts of the Poultry Cleaning Knife has waved pointed tips to remove aggressive debris and the yellowing coloration that sometimes builds on the top of the surface of poultry skins. The Poultry Cleaning Knife bottom blade performs the same main function that uses a straight line blade for general cleaning of the poultry skins. The bodies of the blade are vents to catch any remaining bacteria and or germs that the top or bottom blades did not remove. This stroking action of the Poultry Cleaning Knife, removes salmonella, fatty oils, dirt, and debris from the skins of Chicken, Turkey, and any other kind of poultry. The Poultry Cleaning Knife can remove salmonella and other germs from the poultry by a gliding, scraping motion that collects on the blade and can be washed off easily. Purpose of the Poultry Cleaning Knife is to help remove the amount of salmonella, germs, and oils, from the poultry skins before the poultry is cooked for human consumption. The Poultry Cleaning Knife is to be utilized to prevent salmonella poising and contamination.



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A BACTERIAL VACCINE AND METHODS FOR MANUFACTURE THEREOF

Nº publicación: EP3035957A1 29/06/2016

Solicitante:
BHARAT BIOTECH INT LTD [IN]

Resumen de: WO2015029056A1

Disclosed are stable conjugate vaccine formulations for protection against Salmonella typhi, and methods of conjugation between Vi-polysaccharide of S.typhi to tetanus toxoid as the carrier protein, responsible for producing improved T-dependent immune response against Typhoid fever caused by Salmonella typhi. The methods disclosed in this invention and the resulting formulations are capable of inducing immunity against typhoid fever including in children below 2 years of age, through only a single injection to comprise a complete vaccination schedule.



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MICROORGANISMS AS CARRIERS OF NUCLEOTIDE SEQUENCES CODING FOR CELL ANTIGENS USED FOR THE TREATMENT OF TUMORS

Nº publicación: BRPI0308119A2 28/06/2016

Solicitante:
RAPP R ULF [DE]

Resumen de: CA2513190A1

The invention relates to a microorganism with a nucleotide sequence coding f or a cell antigen in which the following components are inserted and are expressible: I) a nucleotide sequence coding for at least one epitope of an antigen of a tumor cell and/or a nucleotide sequence for at least one epitop e of an antigen that is specific for a tissue cell from which the tumor originates; II) an optional nucleotide sequence coding for a protein that stimulates cells of the immune system; IIIA) a nucleotide sequence for a transport system which makes it possible to express the expression product o f components I) and, optionally, II) on the outer surface of the bacterium and/or secrete the expression product of component I) and, optionally, of component II); and/or IIIB) a nucleotide sequence for a protein used for lysing the microorganisms in the cytosol of mammalian cells and for intracellularly releasing plasmids which are contained in the lysed microorganisms; and IV) an activation sequence for expressing one or several of components I) to IIIB), said activation sequence being selected among the group consisting of an activation sequence which is capable of being activat ed in the microorganism, is tissue-cell-specific but not cell-specific . Each o f components I) to IV) can be identically or differently arranged in an individual or multiple manner. Also disclosed are uses of such a microorgani sm for the production of a medicament.



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PREBIOTIC AND BACTERIAL-BASED PROBIOTIC PATHOGEN INHIBITOR

Nº publicación: WO2016100881A1 23/06/2016

Solicitante:
MICROBIOS INC [US]

Resumen de: WO2016100881A1

A bacterial composition that inhibits E. coli O157:H7 growth by as much as 93% and Salmonella growth by as much as 97%, together with commensurate inhibition rates against the Big-Six Escherichia coli strains referred to as the non-O157 STECs that include E. coli O121:H19; E. coli O45:H2; E. coli O103:H11; E. coli O145, E. coli O26:H11; and E. coli O111. The composition is constituted of various combinations of the following four unique pathogen-inhibiting bacteria: (1) Lactobacillus animalis strain MB101; (2) Lactobacillus animalis strain MB102; (3) Enterococcus faecium strain MB505; and (4) Pediococcus acidilactici strain MB902. Each of the discovered bacteria is deposited with the American Type Culture Collection (ATCC) and respectively has an individual ATCC Accession Number.



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NUCLEOTIDE SEQUENCE CODING FOR A TOLC AND A DEFINED AMINO ACID SEQUENCE

Nº publicación: BRPI0307873A2 21/06/2016

Solicitante:
R ULF RAPP [DE]

Resumen de: CA2513192A1

The invention relates to a nucleotide sequence coding for a TolC and a defin ed amino acid sequence, said defined amino acid sequence being inserted in the permissive, membrane-external area of the TolC, and several uses thereof, particularly bacteria containing such a nucleotide sequence.



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O-ANTIGEN CARBOHYDRATE CHAIN EXTENDED S ALMONELLA PARATYPHI A AND USE THEREOF

Nº publicación: WO2016090980A1 16/06/2016

Solicitante:
INST OF BIOTECHNOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES CHINA [CN]

Resumen de: WO2016090980A1

Provided are an O-antigen carbohydrate chain extended Salmonella paratyphi A and a use thereof. The method comprises the following steps: inactivating a cld geneof the enzyme for controlling the O-antigen chain length of Salmonella paratyphi A, and obtaining Salmonella paratyphi A defects in a cld gene of the enzyme for controlling the O-antigen chain length; overexpressing a cld LT2 gene of the enzyme for controlling the O-antigen chain length of Salmonella typhimurium in the Salmonella paratyphi A defects in the cld gene of the enzyme for controlling the O-antigen chain length, and then extending the O-antigen carbohydrate chain length of Salmonella paratyphi A.



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ESCHERICHIA COLI AS A MARKER FOR HYPERTRIGLYCERIDEMIA

Nº publicación: US2016168627A1 16/06/2016

Solicitante:
NESTEC SA [CH]

Resumen de: WO2015007464A1

The present invention relates to predicting the risk of developing hypertriglyceridemia in a subject by quantitating the amount of enterobacteria, e.g., E. coli, in the subject's gastrointestinal system. The invention also relates to treating a subject with hypertriglyceridemia or at risk of having the condition.



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HYPERBLEBBING SHIGELLA STRAINS

Nº publicación: JP2016105736A 16/06/2016

Resumen de: WO2011036564A2

Hyperblebbing Shigella strains are generated by disrupting one or more components of the Tol-Pal system. The blebs from these strains are useful immunogens for vaccination. The individual proteins found in these blebs can also be used as immunogens.



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VACCINE VECTOR COMPRISING ATTENUATED SALMONELLA ENTERICA TYPHIMURIUM WHICH ARE MUTANTS FOR THE GENE FIS, VACCINE COMPRISING SAID VECTOR AND USE OF SAID VECTOR

Nº publicación: WO2016090440A1 16/06/2016

Solicitante:
UNICAMP [BR]

Resumen de: WO2016090440A1

The development of attenuated live vaccines against salmonellosis has increased over the past years due to the nonexistence of completely effective vaccine formulations which enable different S. enterica serovars to be more effectively controlled. The development of a safe strain that is capable of inducing an efficient immune response involves the production of various attenuated mutants that can be clinically tested or which have unique features that can be combined with other specific mutations, generating increasingly safe and efficient strains. The present invention relates to a vaccine vector comprising mutants for thegene fis, wherein the protein that results from expression thereof, Fis, associates with the bacterial nucleoid regulating the expression of various genes, many of which are related to bacterial pathogenicity. The present invention also relates to a vaccine comprising said mutant strains which generate a response capable of inducing efficient protection against salmonellosis.



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COLIFORM DETECTION PROCESS AND KIT FOR USE THEREIN

Nº publicación: CN105671124A 15/06/2016

Resumen de: WO2010078284A1

A process comprises (a) providing (1) at least one sample suspected of comprising at least one coliform strain, (2) at least one culture device comprising at least one culture medium that is hydrated or hydratable, and (3) at least one particulate concentration agent that is substantially optically transparent when in contact with the culture medium in the culture device when the culture medium is hydrated; (b) placing the particulate concentration agent in contact with the sample such that at least a portion of the coliform strain is bound to the particulate concentration agent to form coliform-bound particulate concentration agent; (c) placing the coliform-bound particulate concentration agent in contact with the culture medium; (d) incubating the culture device comprising the coliform-bound particulate concentration agent in contact with the culture medium, the culture medium being hydrated; and (e) optically detecting the presence of the coliform strain without separating the coliform strain from the particulate concentration agent.



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METHODS FOR PRODUCING SALMONELLA O- ANTIGEN CAPSULES, COMPOSITIONS AND USES THEREOF

Nº publicación: US2016158333A1 09/06/2016

Solicitantes:
WHITE AARON P [CA]
PERERA SUMUNDU R [CA]
LAM SHIRLEY [CA]
GIBSON DEANNA L [CA]
UNIV SASKATCHEWAN [CA]
UNIVERSIYT OF BRITISH COLUMBIA [CA]

Resumen de: WO2015010185A1

Methods of purifying O-Ag capsules from an S. enterica NTS serovar, wherein the O- Ag capsule is substantially free of co-expressed cellulose and LPS, are described, as are immunogenic compositions comprising the O-Ag capsules and methods for treating, preventing and diagnosing Salmonella infections. Also described are constructs and methods for producing S. enterica NTS serovar mutants which over-express the O-Ag capsule.



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NANOPORE BIOSENSORS FOR DETECTION OF PROTEINS AND NUCLEIC ACIDS

Nº publicación: JP2016516735A 09/06/2016

Resumen de: WO2014153625A1

Described herein are nanopore biosensors based on a modified cytolysin protein. The nanopore biosensors accommodate macromoiecules including proteins and nucleic acids, and may additionally comprise ligands with selective binding properties.



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COMPOSITION FOR EVALUATING OR PREDICTING PATIENT'S THERAPEUTIC RESPONSE TO METFORMIN

Nº publicación: US2016160267A1 09/06/2016

Solicitante:
SNU R&DB FOUNDATION [KR]

Resumen de: WO2015008884A1

The present invention relates to a biomarker for evaluating or predicting patient's therapeutic response to metformin, and a use thereof. The present invention relates to a composition and kit for evaluating and predicting patient's therapeutic response to metformin, the composition and the kit each containing an agent capable of detecting at least one microorganism selected from the group consisting of Blautia, Shigella, and Clostridium. Further, the present invention relates to a method for detecting at least one microorganism selected from the group consisting of Blautia, Shigella, and Clostridium, from a sample of the patient, in order to provide information necessary for evaluating or predicting the response to metformin.



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MULTIFUNCTIONAL ORAL VACCINE BASED ON CHROMOSOME RECOMBINEERING

Nº publicación: HK1211980A1 03/06/2016

Solicitante:
US [US]

Resumen de: WO2014043637A1

A recombineered Salmonella typhi Ty21a, compositions and vaccines comprising such a Ty21a, and a method for recombineering comprising inserting a large antigenic region into a bacterial chromosome for the purpose of making multivalent vaccines to protect against one or more disease agents are described herein.



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METHOD FOR PREPARING BACTERIAL POLYSACCHARIDE-MODIFIED RECOMBINANT FUSION PROTEIN AND USE THEREOF

Nº publicación: WO2016082597A1 02/06/2016

Solicitante:
INST OF BIOTECHNOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES CHINA [CN]

Resumen de: WO2016082597A1

Provided are a method for preparing a bacterial polysaccharide-modified recombinant fusion protein and a use thereof. The method comprises: the recombinant fusion protein and the neisseria meningitidis O-oligosaccharyltransferase PgIL are co-expressed in a bacteria defective in O-antigen ligase genes, and the polysaccharides which are endogenous or exogenous for the bacteria itself are connected to the recombinant fusion protein by the O-oligosaccharyltransferase PgIL, and the polysaccharide-modified recombinant fusion protein is thus obtained. The protein can be used for preparing antibodies and vaccines against bacterial polysaccharides.



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Novel Salmonella for treatment of cancer and use thereof

Nº publicación: KR20160062289A 02/06/2016


 

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