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Resultados 55 resultados LastUpdate Última actualización 24/11/2017 [16:38:00] pdf PDF




Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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PROTEINS AND NUCLEIC ACIDS USEFUL IN VACCINES TARGETING KLEBSIELLA PNEUMONIAE

NºPublicación: EP3244918A2 22/11/2017

Solicitante:
EVAXION BIOTECH APS [DK]

Resumen de: WO2016113252A2

The present invention relates to proteins and nucleic acids derived from Klebsiella pneumoniae as well as therapeutic and diagnostic uses of the proteins and nucleic acids.



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ANTIBODIES TARGETING A GALACTAN-BASED O-ANTIGEN OF K. PNEUMONIAE

NºPublicación: CN107371365A 21/11/2017

Resumen de: WO2016131503A1

The invention provides for an isolated antibody that specifically recognizes a galactan-III epitope of the lipopolysaccharide (LPS) O-antigen structure of Klebsiella pneumoniae, which epitope is incorporated in galactan-III repeating units, wherein the galactan-III repeating unit is a branched galactose homopolymer of Formula (I). The invention further provides for a pharmaceutical or diagnostic preparation comprising said antibody, and a method of producing said antibody.



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ATTENUATED LIVE BACTERIA WITH INCREASED ACID RESISTANCE AND METHODS OF USE THEREOF

NºPublicación: US2017327830A1 16/11/2017

Solicitante:
ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIV [US]

Resumen de: US2017327830A1

The present invention relates to inducing acid resistance in a bacterium and methods of increasing the acid resistance of an acid sensitive bacterium.



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Device for Rapid Detection of Infectious Agents

NºPublicación: AU2017248518A1 09/11/2017

Solicitante:
FUNDAMENTAL SOLUTIONS CORP

Resumen de: AU2017248518A1

The invention is directed to a system for use in sample analysis. The system comprises a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card. The test cartridge base may further include a reaction chamber having a central axis, wherein the reaction chamber has the shape of a revolved half ellipse; and an inlet channel connected to the reaction chamber, wherein the inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal, and wherein the inlet channel is offset from the central axis of the reaction chamber.



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Device For Detection Of Analytes And Uses Thereof

NºPublicación: US2017322208A1 09/11/2017

Solicitante:
INVISIBLE SENTINEL INC [US]

Resumen de: US2017322208A1

Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-home pathogens are disclosed.



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MUC1 DECOY PEPTIDES FOR TREATMENT AND PREVENTION OF BACTERIAL INFECTIONS

NºPublicación: US2017319655A1 09/11/2017

Solicitante:
UNIV MARYLAND [US]
THE US DEPARTMENT OF VETERANS AFFAIRS [US]

Resumen de: US2017319655A1

Pseudomonas aeruginosa flagellin protein recruits the mammalian host sialidase enzyme neuraminidase-1 (NEU1) to remove sialic acid residues from the extracellular domain of the mammalian cell-surface protein MUC1 (MUC1-ED), thereby exposing a cryptic binding site on the MUC1-ED protein backbone for flagellin binding. NEU1-driven MUC1-ED desialylation rapidly increases P. aeruginosa adhesion to the airway epithelium. MUC1-ED desialylation also increases MUC1-ED cleavage and shedding from the cell surface, where desialylated, shed MUC1-ED competitively blocks P. aeruginosa adhesion to cell-associated MUC1-ED. Presented herein are data showing that exogenously-administered, deglycosylated MUC1-ED peptides reduced adhesion of P. aeruginosa to airway epithelial cells. Also presented are data showing that administration of P. aeruginosa to mice in combination with deglycosylated MUC1-ED decreased P. aeruginosa recovered from the lungs at 48 hr and 72 hr post-infection. Such findings are extended to the methods of treatment and prevention of bacterial infections defined herein.



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融合表达IBDV VP2蛋白和沙门菌属外膜蛋白RCK的重组乳酸菌菌株及其用途

NºPublicación: CN107312736A 03/11/2017

Resumen de: CN107312736A

本发明公开了种融合表达IBDV VP2蛋白和沙门菌属外膜蛋白RCK的重组乳酸菌菌株及其用途,本发明所述的重组乳酸菌菌株,含有经优化后的编码鸡传染性法氏囊病毒(IBDV)VP2蛋白以及沙门菌属外膜蛋白RCK融合蛋白的基因序列,其能够高效融合表达VP2蛋白和沙门菌属外膜蛋白RCK,且表达的融合蛋白VP2‑RCK以可溶性形式存在于乳酸菌的细胞质中。将本发明的重组乳酸菌菌株直接作为疫苗免疫鸡,实验结果表明:该重组菌株疫苗能有效诱导机体产生特异性的免疫应答,使免疫鸡获得100%的抵抗高致病力vvIBDV致死性攻击的保护,并可清除体内残留的病毒,达到清除性免疫的目的,本发明的提出为鸡传染性法氏囊病的防治提供了种新的技术手段。



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MICROSTRUCTURE ARRAY FOR DELIVERY OF ACTIVE AGENTS

NºPublicación: JP2017532086A 02/11/2017

Resumen de: WO2016033540A1

Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features.



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PROCESS FOR THE INACTIVATION OF SALMONELLA IN RAW POULTRY MEAT

NºPublicación: AU2017202133A1 02/11/2017

Solicitante:
GOBBLERS INC PTY LTD

Resumen de: AU2017202133A1

Abstract The use of high pressure processing (HPP) to reduce the viability of Salmonella bacteria in uncooked chicken meat.



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BIVALENT IMMUNOGENIC CONJUGATE FOR MALARIA AND TYPHOID

NºPublicación: WO2017189448A1 02/11/2017

Solicitante:
US HEALTH [US]
INT VACCINE INST [KR]

Resumen de: WO2017189448A1

Disclosed herein are conjugates including at least one malaria protein or portion thereof and at least one capsular Vi polysaccharide (ViP), wherein the at least one malaria protein is linked to the at least one ViP through at least one linking group. In some embodiments, the at least one malaria protein is Pfs25, Pvs25, Pfs48/45, Pvs48/45, Pfs47, Pvs47, Pfs230, Pvs230, PfCSP, PvCSP, or a portion of any one thereof. Also disclosed herein are compositions including one or more of the conjugates including at least one malaria protein and at least one ViP and a pharmaceutically acceptable carrier, an adjuvant, and/or other components. Disclosed herein are methods for eliciting an immune response in a subject to Plasmodium and/or Salmonella typhi, including administering an effective amount of one or more of the disclosed conjugates or a composition including one or more of the disclosed conjugates to the subject.



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RAPID AND NON-DESTRUCTIVE DETECTION OF INFECTION

NºPublicación: US2017315108A1 02/11/2017

Solicitante:
ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIV [US]

Resumen de: US2017315108A1

The invention relates to methods and devices to identify an infection via light scatter from a tissue surface.



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A NOVEL CONJUGATE FOR VACCINATION AGAINST TYPHOID COMPRISING CHEMICAL CONJUGATE OF VI POLYSACCHARIDE AND FLAGELLIN, A PROCESS FOR PRODUCING THE SAME AND A COMPOSITION COMPRISING THE CONJUGATE

NºPublicación: WO2017187448A1 02/11/2017

Solicitante:
NAT INST IMMUNOLOGY [IN]

Resumen de: WO2017187448A1

The present investigation relates to a conjugate comprising flagellin adjuvant covalently linked to Vi polysaccharide derived from S. typhi for vaccination against typhoid. Both flagellin adjuvant and Vi polysaccharide are from S. typhi which leads to the improved immunogenicity. The conjugate of the present invention may be used as single dose administration without the need of multiple immunizations. The present invention also discloses a nanoparticle composition comprising the conjugate of the present invention.



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MUC1 DECOY PEPTIDES FOR TREATMENT AND PREVENTION OF BACTERIAL INFECTIONS

NºPublicación: EP3236995A2 01/11/2017

Solicitante:
UNIV MARYLAND [US]
THE US DEPT OF VETERANS AFFAIRS [US]

Resumen de: WO2016105536A2

Pseudomonas aeruginosa flagellin protein recruits the mammalian host sialidase enzyme neuraminidase- 1 (NEU1) to remove sialic acid residues from the extracellular domain of the mammalian cell-surface protein MUC l (MUC l -ED), thereby exposing a cryptic binding site on the MUC l -ED protein backbone for flagellin binding. NEU1 -driven MUC l -ED desialylation rapidly increases P. aeruginosa adhesion to the airway epithelium. MUCl -ED desialylation also increases MUC l -ED cleavage and shedding from the cell surface, where desialylated, shed MUCl -ED competitively blocks P. aeruginosa adhesion to cell-associated MUCl -ED. Presented herein are data showing that exogenously-administered, deglycosylated MUCl -ED peptides reduced adhesion of P. aeruginosa to airway epithelial cells. Also presented are data showing that administration of P. aeruginosa to mice in combination with deglycosylated MUC 1 -ED decreased P. aeruginosa recovered from the lungs at 48 hr and 72 hr post-infection. Such findings are extended to the methods of treatment and prevention of bacterial infections defined herein.



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Keto-isovalerate decarboxylase enzymes and methods of use thereof

NºPublicación: NZ717195A 27/10/2017

Solicitante:
BUTAMAX ADVANCED BIOFUELS LLC

Resumen de: NZ717195A

Discloses a method of converting alpha-ketoisovalerate to isobutyraldehyde in a recombinant non-human host cell as part of an isobutanol production pathway. The method comprises a recombinant host cell comprising a heterologous polypeptide with the sequence of SEQ ID NO: 56. The recombinant host cell may be a member of the genera Clostridium, Zymomonas, Escherichia, Salmonella, Serratia, Erwinia, Klebsiella, Shigella, Rhodococcus, Pseudomonas, Bacillus, Lactobacillus, Enterococcus, Alcaligenes, Klebsiella, Paenibacillus, Arthrobacter, Corynebacterium, Brevibacterium, Schizosaccharomyces, Issatchenkia, Kluyveromyces, Yarrowia, Pichia, Candida, Hansenula, or Saccharomyces.



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BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES

NºPublicación: US2017306423A1 26/10/2017

Solicitante:
FUNDAMENTAL SOLUTIONS CORP [US]

Resumen de: US2017306423A1

A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.



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BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES

NºPublicación: US2017306422A1 26/10/2017

Solicitante:
FUNDAMENTAL SOLUTIONS CORP [US]

Resumen de: US2017306422A1

A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.



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BIOSENSOR SYSTEM FOR THE RAPID DETECTION OF ANALYTES

NºPublicación: US2017306424A1 26/10/2017

Solicitante:
FUNDAMENTAL SOLUTIONS CORP [US]

Resumen de: US2017306424A1

A system, device, and method for rapid detection of analytes that includes a living, engineered biosensor cell that is typically a component of the mammalian immune system; a reporter protein that is engineered into and expressed by the living, engineered biosensor cell, wherein the reporter protein emits a detectable signal in response to certain predetermined changes in the cytosol of the living, engineered cell; a signal transduction pathway expressed by the living, engineered biosensor cell, wherein the signal transduction pathway controls a biological process within the cytosol of the living, engineered biosensor cell, and wherein the biochemical process, when it occurs, causes the reporter protein to emit a detectable signal; at least one type of detector molecule that is adapted to bind to a specific analyte; at least one analyte that binds to the detector molecule that is specific to that analyte; a plurality of non-antibody signal transducing elements that are either expressed by the living, engineered biosensor cell or that actively bind to a receptor or a receptor component expressed by the living, engineered biosensor cell, wherein each signal transducing element is adapted to receive a detector molecule.



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IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS

NºPublicación: EP3235506A1 25/10/2017

Solicitante:
QU BIOLOGICS INC [CA]

Resumen de: EP3235506A1

The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.



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Method for detection of Salmonella spp, Cronobacter spp and Listeria� monocytogenesof bacteria in food

NºPublicación: PL416927A1 23/10/2017

Solicitante:
UNIV WARSZAWSKI [PL]
INST CHEMII FIZYCZNEJ POLSKIEJ AKADEMII NAUK [PL]

Resumen de: PL416927A1

Przedmiotem zgłoszenia jest sposób wykrywania bakterii Salmonella spp., Cronobacter spp. oraz L. monocytogenes w żywności przy wykorzystaniu metod hodowlanych sprzężonych z powierzchniowo wzmocnioną spektroskopią Ramana. W zgłoszeniu wykorzystane zostały tylko dwa etapy metod ISO stosowanych w celu wykrycia w żywności wymienionych bakterii. Po tych etapach, wykorzystano wzmocnioną powierzchniowo spektroskopię Ramana w celu detekcji i identyfikacji bakterii.



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METHOD OF DETECTING AN ANALYTE USING CHROMATOGRAPHIC ENRICHMENT

NºPublicación: US2017299586A1 19/10/2017

Solicitante:
3M INNOVATIVE PROPERTIES CO [US]

Resumen de: US2017299586A1

A device is provided. The device comprises a casing comprising an interior, a first opening, and a second opening; and a porous carrier comprising a sample-receiving zone and a target analyte-binding zone. The porous carrier defines a first fluid pathway that extends from the sample-receiving zone to the target analyte-binding zone. At least portion of the porous carrier is disposed in the interior of the casing. A second fluid pathway comprising a central axis extends through the casing from the first opening and the second opening, the second fluid pathway intersecting the porous carrier at the target analyte-binding zone. The central axis is oriented orthogonally with respect to the porous carrier. Methods of using the device to detect a target analyte are also provided.



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METHODS AND KITS FOR THE RAPID DETECTION OF THE ESCHERICHIA COLI O25B-ST131 CLONE

NºPublicación: WO2017178554A1 19/10/2017

Solicitante:
INSERM (INSTITUT NAT DE LA SANT\u00C9 ET DE LA RECH M\u00C9DICALE) [FR]
ASSIST PUBLIQUE-H\u00D4PITAUX DE PARIS (APHP) [FR]
UNIVERSIT\u00C9 PARIS DIDEROT - PARIS 7 [FR]
PASTEUR INSTITUT [FR]
UNIVERSIT\u00C9 PARIS XIII PARIS-NORD [FR]

Resumen de: WO2017178554A1

The present invention relates to methods and kits for the rapid detection of the Escherichia coli O25b-ST131 clone. The inventors have isolated a podoviridae bacteriophage (LM33_P1) infecting the E. coli strain LM33 isolated from ventilator associated pneumonia and which belongs to clone STI3I-025b. By testing different strains of E coli belonging to 129 others various distinct serotypes (including twelve O25a) the inventors found that bacteriophage LM33_P1 is able to infect exclusively O25b strains (none of non-O25b strains could be infected by LM33_P1). The inventors have determined that the specificity displayed by bacteriophage LM33_P1 to infect only 025b serotype strains is based on a very specific polypeptide (Gp17) used by LM33_P1 to attach the bacterial cell via LPS molecule. In particular, the present invention relates to a polypeptide comprising an amino acid sequence having at least 80% of identity with the amino acid sequence set forth in SEQ ID NO:1.



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DIAGNOSING ACUTE BACTERIAL MENINGITIS

NºPublicación: WO2017178826A1 19/10/2017

Solicitante:
THE UNIV OF LIVERPOOL [GB]

Resumen de: WO2017178826A1

The invention relates to a method for diagnosing acute bacterial meningitis in a subject, the method comprising assaying a sample to determine the presence of target molecules representative of expression of each of the proteins in the group consisting of: myeloperoxidase, ceruloplasmin, cystatin C, cathelicidin, and a constituent of calprotectin; and comparing the expression of the proteins in the subject with corresponding reference values, wherein a difference in the expression of the proteins in the subject compared to the reference values is indicative of acute bacterial meningitis. The invention also relates to a method for diagnosing acute bacterial meningitis in a subject, the method comprising: assaying a sample to determine the presence of target molecules representative of expression of at least five proteins selected from the group set out in Table 1; and comparing the expression of the selected proteins in the subject with corresponding reference values, wherein a difference in the expression of the proteins in the subject compared to the reference values is indicative of acute bacterial meningitis. The invention also relates to methods of treating acute bacterial meningitis in a subject diagnosed by the methods of the invention, and to an antimicrobial agent for use in the treatment of a subject diagnosed by the methods of the invention.



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System and Method for Pathogen Detection Using Multiple-Sized Polymer-Coated Beads within Lyotropic Chromonic Liquid Crystals

NºPublicación: US2017299583A1 19/10/2017

Solicitante:
PATHOGEN SYSTEMS INC DBA CRYSTAL DIAGNOSTICS LTD [US]
PATHOGEN SYSTEMS INC D/B/A CRYSTAL DIAGNOSTICS LTD [US]

Resumen de: US2017299583A1

A novel detection system and method is presented, where a two-bead receptor method is used for capturing pathogens, with one type of bead being magnetic and having a size of 3 microns or smaller, and the other type being polymeric and having a size of 3 microns or larger. The first type is used to concentrate a pathogen; the latter is used to create a detectable signal. Fast sensitive detection is achieved by collecting the optical signal created by the distortion of a homeotropically aligned chromonic azo dye in the presence of captured pathogens.



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METHOD FOR TREATMENT OF DISORDERS OF THE GASTROINTESTINAL SYSTEM

NºPublicación: US2017296596A1 19/10/2017

Solicitante:
QUEEN'S UNIV AT KINGSTON [CA]
KINGSTON GENERAL HOSPITAL [CA]
UNIV OF GUELPH [CA]

Resumen de: US2017296596A1

There are provided novel synthetic stool preparations comprising bacteria isolated from a fecal sample from a healthy donor. The synthetic stool preparations are used for treating disorders of the gastrointestinal tract, including dysbiosis, Clostridium difficile infection and recurrent Clostridium difficile infection, prevention of recurrence of Clostridium difficile infection, treatment of Crohn's disease, ulcerative colitis, irritable bowel syndrome, inflammatory bowel disease, and diverticular disease, and treatment of food poisoning such as salmonella. Methods of preparation and methods of use of the synthetic stool preparations are also provided.



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O-ANTIGEN CARBOHYDRATE CHAIN EXTENDED SALMONELLA PARATYPHI A AND USE THEREOF

Nº publicación: EP3231868A1 18/10/2017

Solicitante:
INST OF BIOTECHNOLOGY ACAD OF MILITARY MEDICAL SCIENCES CHINA [CN]

Resumen de: EP3231868A1

The present invention discloses a Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cld LT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB4573 3 -OPS Spty 50973 and rEPA4573-OPS Spty 50973 as prepared by using Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.


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