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Resultados 73 resultados LastUpdate Última actualización 18/02/2018 [16:39:00] pdf PDF




Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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MODIFIED ENDOTOXIC BACTERIA LIPOPOLYSACCHARIDE (VARIANTS), COMBINATION OF MODIFIED LIPOPOLYSACCHARIDES (VARIANTS) AND, CONTAINING SAME, A VACCINE (VARIANTS) AND A PHARMACEUTICAL COMPOSITION (VARIANTS)

NºPublicación: US2018043004A1 15/02/2018

Solicitante:
APARIN PETR GENNADIEVICH [RU]
LVOV VYACHESLAV LEONIDOVICH [RU]
ELKINA STANISLAVA IVANOVNA [RU]
GOLOVINA MARINA EDUARDOVNA [RU]
LEDOV VLADIMIR ALEKSEYEVICH [RU]
MARKINA ANNA ALEKSANDROVNA [RU]
SHEKHT MARIA EVGENEVNA [RU]

Resumen de: US2018043004A1

The modified S-LPS and combinations thereof have high safety profile and provide low pyrogenicity and high immunogenicity. Developed on their basis vaccines and pharmaceutical compositions demonstrate anti-shock activity, high efficiency and specificity, broad-spectrum action and also good chemical-pharmaceutical parameters.



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GUANIDINE-FUNCTIONALIZED PERLITE PARTICLES, ARTICLES CONTAINING THE PARTICLES, AND METHODS OF USING THE PARTICLES AND ARTICLES

NºPublicación: US2018038862A1 08/02/2018

Solicitante:
3M INNOVATIVE PROPERTIES CO [US]

Resumen de: US2018038862A1

Guanidine-functionalized perlite particles are provided. Nonwoven articles are also provided, including a fibrous porous matrix and guanidine-functionalized perlite particles enmeshed in the fibrous porous matrix. Laminated articles are additionally provided, including a first substrate and a second substrate sealed to the first substrate along at least a portion of a perimeter of the first substrate. The laminated article further includes guanidine-functionalized perlite particles disposed between the first substrate and the second substrate. Methods of detecting microorganisms or target cellular analytes in a fluid sample using guanidine-functionalized particles or laminated articles are also provided.



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Nanotube-Based Biosensor for Pathogen Detection

NºPublicación: US2018038815A1 08/02/2018

Solicitante:
UNIV NORTHEASTERN [US]

Resumen de: US2018038815A1

A simple and highly sensitive single walled carbon nanotube (SWNT) sensor is provided for detection of a variety of analytes, including small molecules, macromolecules, and pathogens. The high sensitivity, specificity, stability, and rapid operation of the sensor render it useful for detection and quantification of low level contaminants such as pharmaceuticals and pathogens in environmental samples, including wastewater and natural bodies of water.



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ALUM-CONTAINING COATING FORMULATIONS FOR MICRONEEDLE VACCINE PATCHES

NºPublicación: JP2018502927A 01/02/2018

Resumen de: WO2016122915A1

Compositions for coating microneedles with aluminum-adjuvanted vaccines are provided comprising an aluminum-containing wet gel suspension selected from aluminum hydroxide wet gel suspension and aluminum phosphate wet gel suspension; a vaccine in an amount effective to stimulate an immune response in a mammal; a sugar, sugar alcohol, or combinations thereof; and a thickener. Some embodiments of the compositions have a viscosity of 500 to 30,000 cps when measured at 100s-1 and temperature of 25 C. Microneedle devices coated with the compositions, as well as methods of forming the compositions and coating the microneedles, and methods of maximizing the aluminum content of vaccine-coated microneedle arrays are also provided.



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METHODS FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY EXTRACELLULAR MICROORGANISMS, INCLUDING ANTIMICROBIAL-RESISTANT STRAINS THEREOF, USING GALLIUM COMPOUNDS

NºPublicación: US2018028564A1 01/02/2018

Solicitante:
ICAHN SCHOOL MED MOUNT SINAI [US]
CAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US]

Resumen de: US2018028564A1

The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a patient a compound containing gallium. The extracellular microorganisms targeted by the present methods include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), E. coli O157:H7, fluoroquinolone-resistant Salmonella typhi, and the like. Furthermore, in the present methods, gallium compounds can be co-administered with one or more conventional antimicrobial agents to treat infectious diseases with reduced risks of creating multi-drug resistant pathogens. The methods of the present invention is also applicable to those microorganisms, such as ulcer-causing Helicobacter pylori, complete eradication of which so far has been difficult to achieve.



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USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER

NºPublicación: US2018028628A1 01/02/2018

Solicitante:
CLEVELAND BIOLABS INC [US]

Resumen de: US2018028628A1

The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.



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ANTI-SALMONELLA ANTIBODIES AND USES THEREOF

NºPublicación: US2018030120A1 01/02/2018

Solicitante:
ABCELEX TECH INC [CA]

Resumen de: US2018030120A1

The present disclosure provides anti-Salmonella antibodies or antibody fragments, such as camelid single domain antibodies (VHHs), along with associated nucleic acids, host cells and phages. Methods of reducing the presence of Salmonella in an animal or an animal environment, methods and formulations for treating Salmonella infection, and methods of detecting Salmonella are also described.



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DELIVERING FUNCTIONAL NUCLEIC ACIDS TO MAMMALIAN CELLS VIA BACTERIALLY-DERIVED, INTACT MINICELLS

NºPublicación: US2018028456A1 01/02/2018

Solicitante:
ENGENEIC MOLECULAR DELIVERY PTY LTD [AU]

Resumen de: US2018028456A1

Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.



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ENGINEERED SALMONELLA SEROVAR TYPHIMURIUM STRAINS, COMPOSITIONS THEREOF, AND METHODS OF USE

NºPublicación: WO2018022974A1 01/02/2018

Solicitante:
UNIV NORTH CAROLINA STATE [US]

Resumen de: WO2018022974A1

Provided herein are engineered Salmonella enterica serovar Typhimurium strains and compositions, including vaccines, thereof. Also provided herein are methods of treating and/or preventing infection by at least Salmonella enterica serovar Typhimurium in a subject in need thereof by administering a vaccine provided herein.



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VACCINE DELIVERY METHOD

NºPublicación: EP3275507A2 31/01/2018

Solicitante:
UNIV OF GEORGIA RESEARCH FOUNDATION INC [US]

Resumen de: EP3275507A2

The present invention relates to a vaccine composition comprising:(i) a peptide hydrogel that is a liquid at room temperature and a gel at physiological pH, physiological salt concentrations and/or physiological temperatures; and (ii) one or more antigens; wherein the peptide hydrogel comprises a self-assembling peptide selected from the group consisting of RAD16-I ((RADA)(4); (SEQ ID NO:2)), RAD16-II ((RARADADA)(2); (SEQ ID NO:3)), KFE-8 ((FKFE)(2); (SEQ ID NO:4)), and KLD-12 ((KLDL)(3)); (SEQ ID NO:5)).



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Polysaccharide vaccine formulations and processes for industrial production of bacterial polysaccharides

NºPublicación: AU2016290233A1 25/01/2018

Solicitante:
BHARAT BIOTECH INTERNATIONAL LTD

Resumen de: AU2016290233A1

The present invention relates to the field of combined vaccine compositions which are effective against all forms of meningococcal diseases as well as typhoid fever. The vaccine formulations comprising antigens from capsular polysaccharides of



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Genetic testing for predicting resistance of Salmonella species against antimicrobial agents

NºPublicación: AU2016295174A1 25/01/2018

Solicitante:
ARES GENETICS GMBH

Resumen de: AU2016295174A1

The invention relates to a method of determining an infection of a patient with Salmonella species potentially resistant to antimicrobial drug treatment, a method of selecting a treat- ment of a patient suffering from an antibiotic resistant Sal- monella infection, and a method of determining an antibiotic resistance profile for bacterial microorganisms of Salmonella species, as well as computer program products used in these methods. In an exemplary method, a sample 1 is used for mo- lecular testing 2, and then a molecular fingerprint 3 is tak- en. The result is then compared to a reference library 4, and the result 5 is reported.



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Perforin 2 defense against invasive and multidrug resistant pathogens

NºPublicación: AU2017279777A1 25/01/2018

Solicitante:
UNIV MIAMI

Resumen de: AU2017279777A1

Perforin-2 (P2) is expressed by fibroblasts, microglia and macrophages and was found to be responsible for killing bacteria, for example, Mycobacteria smegmatis, M. 5 avium, Salmonellae, MRSA (drug resistant Stapholococci), E coli. Compounds identified by screening assays are selected based on the effects of these compounds on P2. Use of these compounds in the treatment of infectious diseases, in particular, bacteria and antibiotic-resistant bacteria is also provided.



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NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS

NºPublicación: WO2018015380A1 25/01/2018

Solicitante:
ULSEMER PHILIPPE [DE]
GOLETZ STEFFEN [DE]
GOETZ PETER [DE]

Resumen de: WO2018015380A1

The present invention relates to means and method for isolating naturally-occurring microorganisms (non-pathogenic bacteria, yeasts or fungi) capable of binding toxins from microorganisms such as bacteria, viruses, fungi, yeasts, or protozoans and/or receptors for these toxins on the surface of mammalian cells, thereby making these receptors inaccessible for said toxins. The naturally-occurring microorganisms that are obtainable by the means and methods of the present invention can be used for adsorbing toxins from pathogenic microorganisms and/or blocking receptors for such toxins on the surface of mammalian cells. These toxin-receptor interactions are known to be critical for disease pathogenesis, making both the toxins and receptors a target for the naturally-occurring microorganisms of the present invention.



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DESIGN OF PROTECTIVE ANTI-ZIKV VACCINE WITHOUT INDUCING CROSS-REACTIONS WITH DENGUE

NºPublicación: WO2018018041A1 25/01/2018

Solicitante:
UNIV OF FLORIDA RESEARCH FOUNDATION INCORPORATED [US]

Resumen de: WO2018018041A1

The subject application provides a genetically modified recombinant facultative intracellular invasive bacterial pathogen (RFIIBP) or a recombinant attenuated Salmonella vaccine (RASV) strains encoding Zika virus (ZIKV) antigens. These strains exhibit high immunogenicity, complete safety, and attenuation, and are unable to persist or be shed in an infective or viable form. These RFIIBPs and RASVs also exhibit regulated delayed attenuation in vivo, regulated delayed in vivo synthesis of protective ZIKV antigens. Methods of inducing mucosal, systemic and cellular immunities in hosts are also provided and antibodies produced using the disclosed RFIIBPs and RASVs can comprise neutralizing antibodies against ZIKV that do not crossreact with Dengue virus (DENV).



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USE OF GENE ENGINEERING BACTERIA VPN 20009-M IN PREPARATION OF MEDICAMENTS FOR PREVENTING AND TREATING CANCER METASTASIS

NºPublicación: EP3272363A1 24/01/2018

Solicitante:
NANJING SINOGEN BIOTECH & PHARMACEUTICAL INC [CN]

Resumen de: EP3272363A1

The present invention discloses uses of genetically engineered attenuated Salmonella typhimurium strain VNP20009-M in the manufacture of medicaments for the preventing and treating cancer metastasis. The genetically engineered strain VNP20009-M is targeted to cancer cells and has a significant effect of inhibiting metastasis and growth. VNP20009-M can be used to prepare medicaments for the prevention and treatment of tumor metastasis.



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POULTRY PROBIOTIC VACCINE COMPOSITIONS AND METHODS OF USE THEREOF

NºPublicación: WO2018013530A1 18/01/2018

Solicitante:
UNIV ARKANSAS [US]

Resumen de: WO2018013530A1

Provided herein are compositions including a probiotic including at least one strain of live bacteria and a Marek' s Disease vaccine. Compositions including a probiotic or a probiotic and a Marek' s Disease vaccine may be administered to subjects, including poultry. The compositions may be administered in ovo to increase early lactic acid bacteria in the gastrointestinal tract of the subject, to decrease the gram negative bacteria in the gastrointestinal tract of the subject, to reduce the level of Salmonella in the gastrointestinal tract of the subject and to increase the body weight gain of the subject. Also provided are kits including a probiotic and a Marek' s Disease vaccine.



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PRO-INFLAMMATORY AND ADJUVANT FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS

NºPublicación: JP2018501322A 18/01/2018

Resumen de: WO2016115097A2

The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.



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PROCESS FOR THE PRODUCTION OF A DNA VACCINE FOR CANCER IMMUNOTHERAPY

NºPublicación: WO2018011289A1 18/01/2018

Solicitante:
VAXIMM AG [CH]

Resumen de: WO2018011289A1

The present invention relates to a method for producing a DNA vaccine for cancer immunotherapy comprising at least the steps of (a) transforming an attenuated strain of Salmonella with at least one DNA molecule comprising at least one expression cassette encoding at least one antigen or at least one fragment thereof; (b) characterizing at least one transformed cell clone obtained in step (a); and (c) selecting at least one of the transformed cell clone(s) characterized in step (b) and further characterizing said at least one selected transformed cell clone. The present invention further relates to a DNA vaccine obtainable by the method according to the present invention.



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Способ получения вакцины гидроокисьалюминиевой инактивированной против сальмонеллеза свиней

NºPublicación: RU2016128025A 17/01/2018

 

IMMUNOGENIC COMPOSITIONS

NºPublicación: BE1024284A1 12/01/2018

Solicitante:
GLAXOSMITHKLINE BIOLOGICALS SA [BE]

Resumen de: WO2016202872A1

This invention relates to immunogenic compositions, particularly vaccine compositions, for use in providing protection against illness caused by bacterial infection with Shigella strains.



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USE OF GENETICALLY ENGINEERED STRAIN VNP20009-M IN PREVENTING AND TREATING CANCER METASTASIS

NºPublicación: US2018008682A1 11/01/2018

Solicitante:
NANJING SINOGEN BIOTECH & PHARMACEUTICAL INC [CN]

Resumen de: US2018008682A1

The present disclosure provides uses of genetically engineered attenuated Salmonella typhimurium strain VNP20009-M in preventing and treating cancer metastasis. The genetically engineered strain VNP20009-M is targeted to cancer cells and has a significant effect of inhibiting metastasis and growth. VNP20009-M can be used to prepare medicaments for the prevention and treatment of tumor metastasis.



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A WHEAT BRAN FRACTION FOR USE TO COMBAT SALMONELLA INFECTION

NºPublicación: WO2018007562A1 11/01/2018

Solicitante:
UNIV GENT [BE]
UNIV LEUVEN KATH [BE]

Resumen de: WO2018007562A1

The present invention relates to a method of reducing human salmonellosis due to consumption by contaminated food. More in particular, the present invention discloses a specific wheat bran fraction that reduces colonization of Salmonella bacteria in the gut of animals which are part of the human food chain. The present invention indeed demonstrates that animals such as broilers which are given feed supplemented with the latter feed bran fraction -and are then infected with Salmonella- have a significantly reduced number of Salmonella bacteria in their cecum and shed less bacteria in their environment when compared to control animals which are given non-supplemented feed.



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COMPOSITIONS AND METHODS FOR PEPTIDE EXPRESSION AND PURIFICATION USING A TYPE III SECRETION SYSTEM

NºPublicación: US2018009851A1 11/01/2018

Solicitante:
UNIV OF UTAH RESEARCH FOUNDATION [US]

Resumen de: US2018009851A1

Disclosed are compositions and methods for expressing and purifying a peptide of interest using a Flagellar Type III secretion system. Disclosed are nucleic acid sequences that contain a FlgM nucleic acid sequence, a cleavage site, and a nucleic acid sequence of interest. Also disclosed are polypeptides that contain FlgM, a cleavage site and a peptide of interest. Methods of producing polypeptides that have FlgM, a cleavage site and a peptide of interest are provided.



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Method of Diagnosing Bacterial Infections Using Bacterial Glycoproteins

Nº publicación: US2018011091A1 11/01/2018

Solicitante:
UNIV ALBERTA [CA]
INSTITUTO DE INVESTIG BIOTECNOLOGICAS-INSTITUTO TECNOLOGICO DE CHASCOMUS [AR]

Resumen de: US2018011091A1

The present application provides a method of diagnosing bacterial infections using engineered glycoproteins in an immunoassay. The engineered bacterial glycoproteins used in the immunoassay comprise a bacterial antigen covalently attached to a protein via polysaccharyltransferase (PTase)-mediated glycosylation, wherein the bacterial antigen is selected based on the bacterial infection of interest. Antibodies in a bodily fluid of subjects infected with a bacteria will bind to the engineered glycoprotein, and the resulting binding complexes are detected or quantitated.


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