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Resultados 64 resultados LastUpdate Última actualización 21/09/2017 [22:04:00] pdf PDF




Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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种蛋白自组装新型纳米疫苗及其制备方法

NºPublicación: CN107157933A 15/09/2017

Resumen de: CN107157933A

本发明涉及种蛋白自组装新型纳米疫苗及其制备方法,基于抗原蛋白自组装制备而成,在疫苗制备过程中选择性引入分子佐剂,抗原含量≥85%,无需铝佐剂、弗氏佐剂等辅助即可引发高效免疫效应,利用物理调控暴露蛋白分子间的巯基,通过巯基/二硫键交换反应,形成以二硫键交联为主的稳定的蛋白纳米粒。本发明克服了传统纳米疫苗需引入外源载体或交联剂等缺陷,可同时提高疫苗的免疫效应及生物安全性。所得到的疫苗颗粒形貌规整,稳定性强,调控方式灵活,重复性好,可高效刺激树突细胞成熟。具有较强的通用性、普适性,在系列的抗原蛋白上得到验证,在疫苗新方法及生物制药领域具有潜在重大应用价值。



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BACTERIALLY DERIVED INTACT MINICELLS THAT ENCOMPASS PLASMID FREE DNA AND METHODS OF USING THE SAME

NºPublicación: US2017258734A1 14/09/2017

Solicitante:
ENGENELC MOLECULAR DELIVERY PTY LTD [AU]
ENGENEIC MOLECULAR DELIVERY PTY LTD [AU]

Resumen de: US2017258734A1

Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.



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EMULSIFIED VACCINE TO OBTAIN FORMULATIONS OF CONCENTRATED IGY IMMUNOGLOBULINS; PROCESSES AND USES FOR THE SAME

NºPublicación: US2017258899A1 14/09/2017

Solicitante:
INVESTIG APLICADA S A DE C V [MX]
INVESTIACION APLICADA S A DE C V [MX]

Resumen de: US2017258899A1

The present invention relates to a therapy for treating or preventing several diseases in animals, based on the administration of a highly concentrated avian derived immunoglobulins formulation, obtained from the egg yolk from hens previously hiper-immunized with a vaccine formulation comprising infectious agents or toxins antigens, a light mineral oil and a particulate adjuvant.



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INACTIVATED TRIVALENT SALMONELLA VACCINE COMPOSITION REDUCED IN ENDOTOXIN LEVEL FOR PREVENTION OF FOWL TYPHOID AND SALMONELLOSIS

NºPublicación: WO2017150755A1 08/09/2017

Solicitante:
BEESONBIOGICS CO LTD [KR]

Resumen de: WO2017150755A1

The present invention relates to a vaccine composition for prevention of salmonella infection, and a mixture adjuvant (hereinafter "BeesonBiologics adjuvant, BBL-A1") comprising a trivalent antigen mixture including an msbB gene-deleted Salmonella Galinarum, an msbB gene-deleted Salmonella Enteritidis, and an msbB gene-deleted Salmonella Typhimurium provides an inactivated trivalent vaccine composition (hereinafter "Trivac") for prevention of salmonella infection. Due to the redeeming side effects of conventional oily vaccine compositions in addition to simultaneously preventing the infection of the three serovars, the pharmaceutical composition of the present invention is effectively available for the prevention of salmonella infection.



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VACCINE FOR LIVESTOCK PRODUCTION SYSTEMS

NºPublicación: JP2017525726A 07/09/2017

Resumen de: WO2016033532A1

The invention relates to a live vaccine for protection against enteric bacterial infection.



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USE OF AN AGENT CONSISTING OF ANTIBODIES AND/OR INSULIN-LIKE GROWTH FACTOR ANTAGONISTS

NºPublicación: US2017252438A1 07/09/2017

Solicitante:
MAT-MALTA ADVANCED TECH LTD [MT]
FREISTAAT BAYERN REPRESENTED BY JULIUS-MAXIMILIANS-UNIVERSIT\u00C4T W\u00DCRZBURG [DE]

Resumen de: US2017252438A1

The present invention relates to the use of a composition selected from the group consisting of antibodies, antibody fragments, insulin-like growth factor antagonists, Toll-like receptor antagonists and mixtures thereof for the treatment or the prophylaxis of certain diseases.



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PRODUCTION AND USE OF HYPERIMMUNE EGG - PC2

NºPublicación: EP3212664A1 06/09/2017

Solicitante:
ROMVAC COMPANY SA [RO]

Resumen de: RO130213A0

The invention relates to a process for preparing an immunologic product based on chicken immunoglobulins. According to the invention, the process comprises the immunization of usual egg-laying hens with an antigen mass consisting of a mixture of bacteria, viruses and mushrooms, previously inactivated, in association with a usual adjuvant, after which immune response assessment tests are performed, the hens exhibiting a positive response being admitted for the egg production, wherefrom the eggs containing 100...200 mg lgY and 10...20 mg specific lgY, respectively, are selected and processed for preservation purposes.



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IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS

NºPublicación: JP2017149751A 31/08/2017

Resumen de: WO2012012874A1

The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.



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Antibacterial Peptide and Method of Treatment Using the Antibacterial Peptide

NºPublicación: US2017246240A1 31/08/2017

Solicitante:
UNITED ARAB EMIRATES UNIV [AE]

Resumen de: US2017246240A1

A method of treating or preventing a bacterial infection in an animal comprises administering to the animal an effective amount of an antibacterial peptide, the antibacterial peptide being derived from degraded date pits which are degraded by solid state degradation by a fungus, Trichoderma reesei. The antibacterial peptide has a molecular mass of less than 10 kDa and an amino acid sequence including (a) SEQ ID NO:4 or (b) SEQ ID NO:6. The bacterial infection is caused by a Gram-positive bacteria or a Gram-negative bacteria, for example, a Salmonella species, a Campylobacter species, a Shigella species, an Escherichia species, a Pseudomonas species, and a Staphylococcus species.



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FLAGELLIN COMPOSITONS AND USES

NºPublicación: EA201790294A1 31/08/2017

Resumen de: WO2016019034A1

The present invention relates to compositions comprising improved flagellin derived constructs and methods of using the same in the treatment of various diseases.



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METHOD OF DETECTING A SALMONELLA MICROORGANISM

NºPublicación: US2017247738A1 31/08/2017

Solicitante:
3M INNOVATIVE PROPERTIES CO [US]

Resumen de: US2017247738A1

A method of detecting a Salmonella microorganism is provided. The method includes the use of a selective growth medium, a first indicator system that is converted to a first detectable product by a Salmonella microorganism, and a second indicator system that is converted to a second detectable product by β-galactosidase enzyme activity. The method further comprises inoculating the growth medium and incubating the inoculated growth medium at a temperature higher than 40 degrees C.



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System and Method for Integration of Mobile Device Imaging with Microchip Elisa

NºPublicación: US2017248592A1 31/08/2017

Solicitante:
BRIGHAM AND WOMEN'S HOSPITAL INC [US]

Resumen de: US2017248592A1

A system and method for analyzing a biomarker in a biological sample is provided. A biological sample is loaded onto a microchip and an enzyme-linked immunosorbent assay specific to the biomarker is performed on the microchip. A color image of the microchip is generated using a mobile device and a color intensity of a selected portion of the color image is determined. The color intensity is correlated with a biomarker concentration using a baseline curve calculation and the concentration of the biomarker is then reported.



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GLYCOCONJUGATE VACCINES COMPRISING BASIC UNITS OF A MOLECULAR CONSTRUCT EXPRESSING BUILT-IN MULTIPLE EPITOPES FOR THE FORMULATION OF A BROAD-SPECTRUM VACCINE AGAINST INFECTIONS DUE TO ENTEROPATHOGENIC BACTERIA

NºPublicación: EA201692546A1 31/08/2017

Resumen de: WO2016012587A1

The present invention refers to new glycoconjugate antigens expressing built-in multiple epitopes and to polyvalent glycoconjugate vaccines intended for the protection of mammalians, and particularly for the protection of the human population from enteropathogenic bacteria, such as the Gram-positive anaerobic bacterium Clostridium difficile and the Gram-negative bacteria Salmonella typhi, Escherichia Coli, Vibrio Cholerae, Shigella flexneri, Salmonella typhimurium, Salmonella enteritidis, Salmonella paratyphi A, Shigella sonnei, Shigella dysenteriae, Salmonella cholerasuis, Klebsiella, Enterobacter,Pseudomonas aeruginosa and/or from viral gastrointestinal infections due to human noroviruses.



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IMMUNOGENIC COMPOSITIONS

NºPublicación: AR105010A1 30/08/2017

Solicitante:
GLAXOSMITHKLINE BIOLOGICALS SA [BE]

Resumen de: WO2016202872A1

This invention relates to immunogenic compositions, particularly vaccine compositions, for use in providing protection against illness caused by bacterial infection with Shigella strains.



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融合表达鸡传染性法氏囊病毒VP2蛋白和沙门菌属外膜蛋白的重组乳酸菌菌株及其用途

NºPublicación: CN107099496A 29/08/2017

Resumen de: CN107099496A

本发明公开了种融合表达鸡传染性法氏囊病毒VP2蛋白和沙门菌属外膜蛋白的重组乳酸菌菌株及其用途。本发明所述的重组乳酸菌菌株,含有经优化后的编码鸡传染性法氏囊病毒VP2蛋白的基因序列以及编码沙门菌属外膜蛋白OMP的基因序列。实验证明该重组乳酸菌菌株其能够高效融合表达VP2蛋白和外膜蛋白OMP,且以可溶性形式存在于细胞质中。将本发明的重组乳酸菌菌株直接作为疫苗免疫鸡,实验结果表明:该重组乳酸菌菌株能有效诱导机体产生特异性的免疫应答,主要产生特异性中和抗体,使免疫鸡获得100%的抵抗高致病力vvIBDV致死性攻击的保护,并可清除体内残留的病毒,达到清除性免疫的目的。因此,本发明的提出为鸡传染性法氏囊病的防治提供了种新的技术手段。



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A SYNERGISTIC COMPOSITION COMPRISING A MIXTURE OF BACTERIA OF THE GENERA LACTOBACILLUS AND PROPIONOBACTERIUM PARTICULARLY USEFUL TO REDUCE OR ELIMINATE PATHOGEN CONTAMINATION IN SOYBEN MEAL AND ITS DERIVATIVES; METHODS AND USES THEREOF

NºPublicación: US2017238571A1 24/08/2017

Solicitante:
MOLINOS R\u00CDO DE LA PLATA S A [AR]
MOLINOS IP S A [CH]
MOLINOS RIO DE LA PLATA S A [AR]

Resumen de: US2017238571A1

The invention discloses a synergistic composition comprising a mix of bacteria of the genera Lactobacillus and Propionibacterium which is particularly useful to reduce or eliminate contamination by bacteria of the genus Salmonella and fungi, thus also preventing the occurrence of mycotoxins in soybean meal and its derivatives.



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METHODS OF PASTEURIZATION ENABLING THE TOTAL INACTIVATION OF VIRAL AND BACTERIAL CONTAMINATION OF IN-SHELL CHICKEN EGGS

NºPublicación: US2017238567A1 24/08/2017

Solicitante:
DAVIDSON L JOHN [US]

Resumen de: US2017238567A1

There is a process which can pasteurize in-shell chicken eggs to inactivate pathogens when present which includes all strains of salmonella and all strains of viruses that historically have been known to exist within chicken eggs and currently are known to be evolving into new and separate strains which may cause large quantities of human illnesses unless countermeasures are developed and employed. One such countermeasure is provided through pasteurization of the subject in-shell eggs through pasteurization involving concurrently a secured environment together with a protocol which enables total inactivation of the targeted pathogens whether bacterial or viral without risk of recontamination.



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METHODS AND COMPOSITIONS FOR THE TREATMENT OF RADIATION-RELATED DISORDERS

NºPublicación: EP3206708A2 23/08/2017

Solicitante:
CLEVELAND BIOLABS INC [US]

Resumen de: WO2016109002A2

This invention relates, in part, to methods and compositions that are useful for the treatment and/or prevention of various disorders, including radiation-related disorders, such as acute radiation syndrome.



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Avirulent Salmonella Gallinarum Variants and Pharmaceutical Composition Using the Same

NºPublicación: CN107083351A 22/08/2017

Resumen de: US2012294892A1

The present invention relates to avirulent Salmonella Gallinarum variants by inactivating virulence gene clusters of Salmonella Gallinarum (SG), a main pathogen of avian salmonellosis, and various uses thereof notably in the production of Salmonella-specific lytic bacteriophages, pharmaceutical compositions and feed additives.



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REAL-TIME DETECTION OF WATER CONTAMINANTS

NºPublicación: CN107076698A 18/08/2017

Resumen de: WO2016019381A1

Provided herein is a field-effect transistor based sensor for real-time detection of water contaminants and methods of use thereof.



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FLAGELLIN COMPOSITONS AND USES

NºPublicación: CN107073092A 18/08/2017

Resumen de: WO2016019034A1

The present invention relates to compositions comprising improved flagellin derived constructs and methods of using the same in the treatment of various diseases.



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EMULSIFIED VACCINE TO OBTAIN FORMULATIONS OF CONCENTRATED IGY IMMUNOGLOBULINS; PROCESSES AND USES FOR THE SAME.

NºPublicación: CN107073098A 18/08/2017

Resumen de: WO2016027135A1

The present invention relates to a therapy for the treatment or prevention of diverse diseases in animals, based on the administration of a formulation of highly concentrated immunoglobulins of avian origin obtained from egg yolk from hens previously hyperimmunised with a vaccine formulation comprising antigens of infectious agents or toxins, a light mineral oil and a particulate adjuvant.



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DUAL ADJUVANT VACCINE COMPOSITIONS, PREPARATION AND USES

NºPublicación: CN107073097A 18/08/2017

Resumen de: WO2015195504A1

The present invention relates to vaccines comprising an effective amount of at least one antigen in a water-in-oil-in-water (WOW) emulsion and an additional adjuvant, and to the methods of preparation and uses thereof.



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EXPRESSION OF A SINGLE CHAIN ANTIBODY AGAINST SALMONELLA IN LACTOBACILLUS

NºPublicación: CN107074934A 18/08/2017

Resumen de: WO2015145250A2

The present disclosure relates to camel id antibodies that inhibit growth, and colonization of Salmonella serovars. The present disclosure also relates to a modified Lactobacillus as a delivery vehicle for controlling salmonella in a host organism.



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REAL-TIME DETECTION OF WATER CONTAMINANTS

Nº publicación: US2017234861A1 17/08/2017

Solicitante:
UWM RES FOUND INC [US]

Resumen de: US2017234861A1

Provided herein is a field-effect transistor based sensor for real-time detection of water contaminants and methods of use thereof.


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