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Resultados 70 resultados LastUpdate Última actualización 26/04/2017 [16:08:00] pdf PDF




Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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Method For Using Protein Databases To Identify Microorganisms

NºPublicación: US2017108509A1 20/04/2017

Solicitante:
VIRGIN INSTR CORP [US]

Resumen de: US2017108509A1

A method for identifying microorganisms by MALDI-TOF mass spectrometry includes acquiring a MALDI mass spectrum of a microorganism, detecting peaks in the acquired MALDI spectrum, generating a peak list comprising mass and intensity from the detected peaks in the acquired MALDI spectrum, acquiring a database of protein sequences deduced from DNA sequences for microorganisms, generating a sub-database of ribosomal proteins from the protein sequences and their masses in the database, matching masses of the detected peaks in the acquired MALDI spectrum to masses of the ribosomal proteins in the generated sub-database, scoring the matches obtained above for each represented microorganism, generating a peak list of accurate masses of matched ribosomal proteins, recalibrating the peak list comprising mass and intensity with the peak list of accurate masses of matched ribosomal proteins, identifying a microorganism with the highest score, and repeating until a desired improvement in the recalibrated peak list or a validated identification is achieved.



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DUAL ADJUVANT VACCINE COMPOSITIONS, PREPARATION AND USES

NºPublicación: EP3154575A1 19/04/2017

Solicitante:
BIOMUNE COMPANY [US]

Resumen de: WO2015195504A1

The present invention relates to vaccines comprising an effective amount of at least one antigen in a water-in-oil-in-water (WOW) emulsion and an additional adjuvant, and to the methods of preparation and uses thereof.



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HELICOBACTER THERAPEUTIC

NºPublicación: CN106573038A 19/04/2017

Resumen de: WO2016000022A1

The present invention relates to method of treating and/or preventing inflammation in a subject caused by bacteria that express HtrA. The present invention further relates to immunogenic compositions comprising an HtrA polypeptide or fragment thereof, as well as a therapeutic and/or prophylactic vaccine for treating or preventing disease.



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BIRD FEED AND IN PARTICULAR POULTRY FEED, COMPRISING SYNTHETIC CAPSAICINOID DERIVATIVES AND SUCH FEED FOR PROHYLACTIC USE OR TREATMENT OF SALMONELLA INFECTION

NºPublicación: WO2017061871A1 13/04/2017

Solicitante:
AXICHEM AB [NO]

Resumen de: WO2017061871A1

The invention relates to bird feed comprising synthetic capsaicinoids for prohylactic use or treatment of salmonella infection.



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Methods of Treating Salmonella-Induced Diarrhea in Non-Human Animals

NºPublicación: US2017095442A1 06/04/2017

Solicitante:
JAGUAR ANIMAL HEALTH INC [US]

Resumen de: US2017095442A1

Provided are methods of treating diarrhea, particularly malabsorption diarrhea, in neonatal, young and adult non-human animals, in which the diarrhea results from infection of the animals by Salmonella spp., such as Salmonella typhimurium, with a therapeutically effective amount of a proanthocyanidin polymer from Croton lechleri, in either enteric or non-enteric form.



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METHODS FOR ENHANCING THE IMMUNOSTIMULATION POTENCY OF ALUMINUM SALT-ADSORBED VACCINES

NºPublicación: JP2017509713A 06/04/2017

Resumen de: WO2015147899A1

Provided herein are (1) a method of mixing an aluminum salt-adsorbed immunogen with a monophosphoryl lipid A (MPLA)-containing liposome (L(MPLA)), and (2) the resulting immunogenic composition. The resulting immunogenic composition has an enhanced immunostimulation potency compared with either a composition comprising the uncapsulated immunogen mixed with the L(MPLA) or the aluminum salt-adsorbed immunogen alone.



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METHOD FOR INCREASING ETEC CS6 ANTIGEN PRESENTATION ON CELL SURFACE AND PRODUCTS OBTAINABLE THEREOF

NºPublicación: BR112014005596A2 04/04/2017

Solicitante:
SCANDINAVIAN BIOPHARMA HOLDING AB [SE]

Resumen de: WO2013037718A1

A method for increasing the presentation of ETEC CS6 antigen on cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100 %. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.



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Analyte detection devices, multiplex and tabletop devices for detection of analytes, and uses thereof

NºPublicación: NZ710838A 31/03/2017

Solicitante:
INVISIBLE SENTINEL INC

Resumen de: NZ710838A

A device for detecting an analyte, within a sample, comprising a housing member. The housing member comprising an inlet, a force member (2070), a moveable locking member (2065), an analyte detection membrane system (2047), an attachment member (2066), and a channel system (2300). The inlet allows a sample to be added into the system for testing and connects with the channel system (2300). The force member (2070) provides a compressing force to the analyte detection membrane system (2047). The moveable locking member (2065) maintains the force member against the membrane system until the sample is ready for testing. The locking system may be activated to release the force member and remove the compressing force from the membrane system. The analyte detection membrane system (2047) comprises a conjugate pad, a permeable membrane, a test membrane and an absorbent member. The membrane system may be arranged with each layer stacked one on top of the other such that the fluid from the channel system may flow through each layer in order. The attachment member (2066) may be attached to the moveable locking member (2065) and the conjugate pad (2050) such that the conjugate pad may be removed from the membrane system when the locking member is actuated. Removal of the conjugate pad can expose the test membrane underneath. The device may comprise multiple membrane systems each arranged to test for a different analyte, the channel system may comprise multiple channels for directing a por



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Immunogenic anti-inflammatory compositions

NºPublicación: NZ702796A 31/03/2017

Solicitante:
QU BIOLOGICS INC

Resumen de: NZ702796A

Disclosed is an a whole killed bacterial cell anti-inflammatory composition in the manufacture of a medicament for treating an individual for an inflammatory disease of the bone, wherein the anti-inflammatory composition comprises a whole killed bacterial cells selected or formulated so that together they are specific for at least one microbial pathogen that is pathogenic in the bone, and wherein the microbial pathogen is selected from the group consisting of Staphylococcus aureus, coagulase-negative staphylococci, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus agalactiae, other streptococci spp., Escherichia coli, Pseudomonas spp., Enterobacter spp., Proteus spp., Serratia spp. paNovirus B 19, rubella virus, hepatitis B.



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MDR E. COLI SPECIFIC ANTIBODY

NºPublicación: US2017087236A1 30/03/2017

Solicitante:
ARSANIS BIOSCIENCES GMBH [AT]

Resumen de: US2017087236A1

The subject relates to an isolated antibody that specifically binds to O25b antigen of multi drug resistant (MDR) E. coli strains, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated epitope recognized the specific antibody.



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Immunizing compositions and methods of use

NºPublicación: US2017087238A1 30/03/2017

Solicitante:
EPITOPIX LLC [US]

Resumen de: US2017087238A1

The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccarhide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.



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CARRIER FOR DETECTING FOODBORNE-ILLNESS-CAUSING BACTERIA, KIT FOR DETECTING FOODBORNE-ILLNESS-CAUSING BACTERIA, METHOD FOR DETECTING FOODBORNE-ILLNESS-CAUSING BACTERIA, AND PCR REACTION SOLUTION FOR FOODBORNE-ILLNESS-CAUSING BACTERIA

NºPublicación: US2017088882A1 30/03/2017

Solicitante:
TOYO SEIKAN GROUP HOLDINGS LTD [JP]

Resumen de: US2017088882A1

A carrier for detecting food poisoning bacteria that is used to simultaneously detect Escherichia coli, Salmonella, Staphylococcus aureus, and Vibrio parahaemolyticus includes a plurality of probes comprising: a probe from a region of pyrH gene of Escherichia coli; a probe from a region of vtx1 gene of Escherichia coli; a probe from a region of vtx2 gene of Escherichia coli; a probe from a region of invA gene of Salmonella; a probe from a region of dnaJ gene of Staphylococcus aureus; a probe from a region of toxR gene of Vibrio parahaemolyticus; a probe from a region of tdh gene of Vibrio parahaemolyticus; a probe from a region of trh1 gene of Vibrio parahaemolyticus; and a probe from a region of trh2 gene of Vibrio parahaemolyticus, wherein the probes are immobilized on the carrier.



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COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO ENTERIC PATHOGENS

NºPublicación: HK1219045A1 24/03/2017

Solicitante:
THE BOARD OF TRUSTEES OF THE UNIV OF ARKANSA [US]

Resumen de: WO2014152508A1

Vaccine vectors capable of eliciting an immune response to enteric bacteria and methods of using the same are provided. The vaccine vectors include a polynucleotide encoding a PAL polypeptide. The PAL polypeptide may be expressed on the surface of the vaccine vector. The vaccine vector may also include a second polypeptide encoding an immunostimulatory polypeptide such as a CD 154 polypeptide or an HMGB1 polypeptide.



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Phage Therapy of E coli infections

NºPublicación: JP2017507913A 23/03/2017

Resumen de: EP2893933A1

The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Escherichia coli strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.



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TUMOR ASSOCIATED VACCINES AND COMPOSITIONS FOR DISRUPTING TUMOR-DERIVED IMMUNOSUPPRESSION FOR USE IN COMBINATION CANCER IMMUNOTHERAPY

NºPublicación: US2017081671A1 23/03/2017

Solicitante:
HOPE CITY [US]

Resumen de: US2017081671A1

In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided. Such a therapeutic composition may include a Salmonella strain comprising a plasmid that expresses an shRNA molecule that suppresses the expression of an immunosuppressive target and suppresses tumor growth. In some aspects, the Salmonella strain is an attenuated Salmonella typhimurium strain. In other aspects, the immunosuppressive target is STAT3, IDO1, IDO2, Arginase 1, iNOS, CTLA-4, TGF-β, IL-10, pGE2 or VEGF. In one embodiment, the immunosuppressive target is IDO1 or Arg1 and the shRNA molecule is any one of SEQ ID NO:5-14.



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SALMONELLA CHOLERAESUIS-SALMONELLA TYPHIMURIUM VACCINES

NºPublicación: WO2017048677A1 23/03/2017

Solicitante:
BOEHRINGER INGELHEIM VETMEDICA INC [US]

Resumen de: WO2017048677A1

The present invention relates methods of reducing fecal shedding of animals infected with Salmonella by use of a vaccine or immunogenic composition of Salmonella Choleraesuis-Typhimurium.



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FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF

NºPublicación: US2017080051A1 23/03/2017

Solicitante:
CLEVELAND CLINIC FOUND [US]

Resumen de: US2017080051A1

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.



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COMPOSITIONS PRODUCED USING ENTERIC PATHOGENS AND METHODS OF USE

NºPublicación: US2017080073A1 23/03/2017

Solicitante:
EPITOPIX LLC [US]

Resumen de: US2017080073A1

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.



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COMPOSITIONS PRODUCED USING ENTERIC PATHOGENS AND METHODS OF USE

NºPublicación: US2017080074A1 23/03/2017

Solicitante:
EPITOPIX LLC [US]

Resumen de: US2017080074A1

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.



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Compositions And Methods For Immunodominant Antigens

NºPublicación: US2017081659A1 23/03/2017

Solicitante:
IMMPORT THERAPEUTICS INC [US]

Resumen de: US2017081659A1

Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.



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Device For Detection Of Target Molecules And Uses Thereof

NºPublicación: US2017082613A1 23/03/2017

Solicitante:
INVISIBLE SENTINEL INC [US]

Resumen de: US2017082613A1

Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.



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种沙门氏菌鞭毛融合蛋白及其编码基因和应用

NºPublicación: CN106519039A 22/03/2017

Resumen de: CN106519039A

本发明涉及基因工程技术领域,具体地,本发明涉及种沙门氏菌鞭毛融合蛋白及其编码基因和应用。本发明的沙门氏菌鞭毛融合蛋白FliC‑CTB,其氨基酸序列如SEQ ID NO.1所示。本发明的基因fliC‑CTB,编码上述沙门氏菌鞭毛融合蛋白FliC‑CTB,其碱基序列如SEQ ID NO.2或3所示。本发明利用植物遗传转化技术,将沙门氏菌fliC基因与霍乱肠毒素B亚基基因融合转入马铃薯,筛选获得转基因植株,并在分子水平上证实了目的基因的整合、转录和表达,过对植物外源融合蛋白检测,证明融合蛋白具有抗原活性,利用本发明的融合基因植物表达载体可将马铃薯作为生物反应器表达该融合蛋白。也可通过本发明继续研发沙门氏菌“通用植物口服疫苗”,为沙门氏菌病防治提供种新的有效的解决途径。



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O157 BSP10 Bacteriophage against Salmonella pathogen E. coli O157 Shigella and composition threrof

NºPublicación: KR20170031516A 21/03/2017

Resumen de: KR20170031516A

본 발명은 마이오비리대()에 속하는 박테리오파지 BSP10 (KACC97026P), 이를 포함하는 세균 사멸용 조성물 및 세균사멸용 미생물 제제에 관한 것으로서, 본 발명의 파지는 다수의 살모넬라균에 감염능력이 있으며, 병원성이 높은 대장균인 O157 균 및 이질균에 대한 감염능력을 동시에 보인다. 본 발명은 생물학적 조절제 역할을 수행할 수 있는데, 식품산업과 농축산업에 병원성 미생물 오염으로 인한 경제적 손실을 절감할 수 있으며, 기존 항생제에 대한 내성 여부와 상관없이 살모넬라균, 병원성 대장균 O157 및 이질균을 동시에 사멸시킬 수 있다. 본 발명의 파지는 살모넬라균, 병원성 대장균 O157 및 이질균의 감염에 대한 질환 치료용으로 사용할 수 있는데, 특히 항생제 내성을 갖는 살모넬라균, 독성이 강한 대장균 O157 및 이질균에 사용시 기존 항생제로 제거할 수 없었던 항생제 내성균을 사멸시킬 수 있으며, 항생제와는 달리 병원성이 없는 유용한 대장균에는 영향을 미치지 않는다는 독특한 특성을 가져 기존 항생제의 대체물로 유용하게 활용될 수 있다.



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LAMP Primers used for LAMP reaction for the detection of Salmonella and its use

NºPublicación: KR20170030746A 20/03/2017

Resumen de: KR20170030746A

본원은 식중독균인 살모넬라를 등온증폭 방식으로 특이적으로 검출할 수 있는 프라이머 세트, 이를 포함하는 조성물 또는 키트, 및 이를 이용한 방법을 개시한다. 본원에 따른 프라이머 세트는 높은 민감도와 특이성은 물론 신속하게 검체 또는 식품 내 병원체의 감염 또는 오염 여부 검출할 수 있으며, 또한 필요한 경�xC6B0; 반응 종결 후 전기영동과 같은 별도의 처리 없이 바로 검출이 가능하여 편리성이 증대된다.



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Method to Introduce Salmonella Into Ground Meat

Nº publicación: US2017074862A1 16/03/2017

Solicitante:
TEXAS TECH UNIV SYSTEM [US]
UNITED STATES DEPT OF AGRICULTURE [US]

Resumen de: US2017074862A1

The present invention includes a method of introducing a pathogenic infection into one or more peripheral lymph nodes of an animal for testing of meat, comprising: inoculating at one or more peripheral lymph node drainage areas the animal with a known amount of a known pathogen; harvesting one or more peripheral lymph nodes from the animal; grinding meat or meat trimmings and the one or more peripheral lymph nodes into ground meat; and determining a ratio of a number of peripheral lymph nodes infected to the weight of the meat or meat trimmings used to create the ground meat, wherein the infected ground meat can be used to test interventions against the known pathogen in a grinding process.


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