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Resultados 64 resultados LastUpdate Última actualización: 25/08/2016 [22:08:00] pdf PDF




Solicitudes de Patente publicadas en los últimos 90 días / Patent Applications published in the last 90 days



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REDUCTION OF THE CONCENTRATION OF GRAM-NEGATIVE BACTERIA IN A FERMENTED FOOD PRODUCT BY THE COMBINATION OF RED WINE EXTRACT AND A CULTURE COMPRISING AT LEAST ONE BACTERIOCIN-PRODUCING LACTIC ACID BACTERIAL STRAIN

Nº publicación: WO2016128508A1 18/08/2016

Solicitante:
CHR HANSEN AS [DK]

Resumen de: WO2016128508A1

The present invention relates to a method of reducing the concentration of Gram-negative bacteria in a food product, the method comprising adding a red wine extract produced from red wine by dealcoholization, concentration and drying, and a culture comprising at least one class IIa bacteriocin-producing lactic acid bacterial strain to a food product, ripening the food product, and storing the food product at a temperature of at the most 15 ̊C until a concentration less than 1 E-1 of Gram-negative bacteria. In a preferred embodiment of the invention, Gram-negative bacteria already present are eliminated. In one embodiment of the invention, the Gram-negative bacteria are Salmonella ssp.. The bacteriocin-producing culture may comprise at least one of Lactobacillus curvatus (DSM 18775) and Pediococcus acidilactici (DSM 28307). The invention further relates to a kit for reducing the concentration of Gram-negative bacteria in a food product comprising a red wine extract produced from red wine by dealcoholization, concentration and drying, and a culture comprising at least one class IIa bacteriocin-producing lactic acid bacterial strain.



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伤寒糖蛋白的生物制备方法及其应用

Nº publicación: CN105861535A 17/08/2016

Resumen de: CN105861535A

本发明公开了种伤寒糖蛋白的生物制备方法及其应用。本发明公开种细菌多糖修饰的蛋白的制备方法,包括将脑膜炎奈瑟球菌O-寡糖转移酶PglL的底物蛋白与脑膜炎奈瑟球菌O-寡糖转移酶PglL在O-抗原连接酶基因缺陷的细菌中共表达,得到细菌多糖修饰的蛋白。本发明在提高疫苗的均性,提高疫苗的生产效率,降低成本,具有广泛的应用前景,可用于预防伤寒病原菌引起的疾病。



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LPS VACCINE

Nº publicación: US2016228526A1 11/08/2016

Solicitante:
THE CHEMO-SERO-THERAPEUTIC RES INST [JP]

Resumen de: EP2829281A1

A vaccine composition for birds comprising as an active ingredient a structure containing 0-antigen derived from Gram-negative bacteria, provided that said structure does not contain a whole cell, and a process for preparing the same are provided. By using a structure containing 0-antigen (e.g. lipopolysaccharide) derived from Gram-negative bacteria as an active ingredient in accordance with the present invention, alleviation of inoculation reaction and reduction in an amount of injection are attained as compared to the conventional whole -cells vaccine to thereby allow for the increase in the number of other antigens to be mixed therewith.



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ENCAPSULATED SENSORS AND SENSING SYSTEMS FOR BIOASSAYS AND DIAGNOSTICS AND METHODS FOR MAKING AND USING THEM

Nº publicación: US2016231324A1 11/08/2016

Solicitante:
THE REGENTS OF THE UNIV OF CALIFORNIA [US]

Resumen de: WO2015048173A2

In alternative embodiments, the invention provides high throughput, multiplexed systems or methods for detecting a biological, a physiological or a pathological maker, or a single molecule or a single cell using a droplet microfluidics system integrated with use of a sensor or a sensing system, an aptamer, or a DNAzyme. In alternative embodiments, the sensor or sensing system comprises a nucleic acid based, an antibody based, an enzyme based or a chemical based sensor or sensing system. In alternative embodiments, the invention provides methods for detecting a biological, a physiological or a pathological marker, or a single molecule or a single cell using a droplet system integrated with rapid and sensitive fluorescence detection systems including, for example, a 3D Particle Detector. In alternative embodiments, the invention provides systems comprising Integrated Comprehensive Droplet Digital Detection (IC 3D).



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ANTI-SALMONELLA ANTIBODIES AND USES THEREOF

Nº publicación: WO2016125089A1 11/08/2016

Solicitante:
ABCELEX TECHNOLOGIES INC [CA]

Resumen de: WO2016125089A1

The present disclosure provides anti-Salmonella antibodies or antibody fragments, such as camelid single domain antibodies (VHHs), along with associated nucleic acids, host cells and phages. Methods of reducing the presence of Salmonella in an animal or an animal environment, methods and formulations for treating Salmonella infection, and methods of detecting Salmonella are also described.



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Isolation, Detection and Use of Biological Cells

Nº publicación: US2016223441A1 04/08/2016

Solicitante:
GJERDE DOUGLAS T [US]

Resumen de: US2016223441A1

This invention relates to devices and methods for purifying, detecting and using biological cells. A variety of cell types including viable tumor, stem, immune and sperm cells can be purified from a complex biological sample using a column, including a pipette tip column. Methods of the invention can aid research, diagnosis and treatment of cancer. Purified viable cells can be detected on the column or eluted from the column and detected. Cells on a column can be used as a stationary phase for liquid chromatography. Cells may be removed, recovered and analyzed.



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COMPOSITIONS AND METHODS FOR RAPID DETECTION OF SALMONELLA

Nº publicación: US2016222440A1 04/08/2016

Solicitante:
ENVIROLOGIX INC [US]

Resumen de: WO2016122698A1

The present invention features rapid and accurate methods for detecting Salmonella (e.g., in a food product, environmental sample, biological sample or other material).



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USE AND MAKING OF BIOSENSORS UTILIZING ANTIMICROBIAL PEPTIDES FOR HIGHLY SENSITIVE BIOLOGICAL MONITORING

Nº publicación: US2016223538A1 04/08/2016

Solicitantes:
MCALPINE MICHAEL C [US]
MANNOOR MANU SEBASTIAN [US]
THE TRUSTEES OF PRINCETON UNIV [US]

Resumen de: US2012156688A1

A biosensor and method of making are disclosed. The biosensor is configured to detect a target and may include a peptide immobilized on a sensing component, the sensing component having an anode and a cathode. The immobilized peptide may comprise an antimicrobial peptide binding motif for the target. The sensing component has an electrical conductivity that changes in response to binding of the immobilized peptide to the target. The immobilized peptide may bind one or more targets selected from the list consisting of: bacteria, Gram-negative bacteria, Gram-positive bacteria, pathogens, protozoa, fungi, viruses, and cancerous cells. The biosensor may have a display with a readout that is responsive to changes in electrical conductivity of the sensing component. The display unit may be wirelessly coupled to the sensing component. A resonant circuit with an inductive coil may be electrically coupled to the sensing component. A planar coil antenna may be disposed in proximity to the resonant circuit, the planar coil antenna being configured to provide power to the sensing component.



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Use of the Salmonella SPP Type III Secretion Proteins as a Protective Vaccination

Nº publicación: US2016220655A1 04/08/2016

Solicitantes:
THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIV [US]
UNIV OF KANSAS [US]

Resumen de: US2016220655A1

Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.



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COMPOSITIONS AND METHODS FOR RAPID DETECTION OF SALMONELLA

Nº publicación: WO2016122698A1 04/08/2016

Solicitante:
ENVIROLOGIX INC [US]

Resumen de: WO2016122698A1

The present invention features rapid and accurate methods for detecting Salmonella (e.g., in a food product, environmental sample, biological sample or other material).



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ENCAPSULATED SENSORS AND SENSING SYSTEMS FOR BIOASSAYS AND DIAGNOSTICS AND METHODS FOR MAKING AND USING THEM

Nº publicación: EP3049067A2 03/08/2016

Solicitante:
UNIV CALIFORNIA [US]

Resumen de: WO2015048173A2

In alternative embodiments, the invention provides high throughput, multiplexed systems or methods for detecting a biological, a physiological or a pathological maker, or a single molecule or a single cell using a droplet microfluidics system integrated with use of a sensor or a sensing system, an aptamer, or a DNAzyme. In alternative embodiments, the sensor or sensing system comprises a nucleic acid based, an antibody based, an enzyme based or a chemical based sensor or sensing system. In alternative embodiments, the invention provides methods for detecting a biological, a physiological or a pathological marker, or a single molecule or a single cell using a droplet system integrated with rapid and sensitive fluorescence detection systems including, for example, a 3D Particle Detector. In alternative embodiments, the invention provides systems comprising Integrated Comprehensive Droplet Digital Detection (IC 3D).



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预防和治疗辐射损伤的蛋白CAA′及其应用

Nº publicación: CN105820218A 03/08/2016

Resumen de: CN105820218A

本发明公开了种预防和治疗辐射损伤的蛋白CAA′及其应用。本发明提供了种环化蛋白(命名为蛋白CAA′),是如下(a1)或(a2)或(a3)或(a4):(a1)序列7自N末端第11至305位氨基酸残基组成的环化蛋白;(a2)序列7自N末端第3至311位氨基酸残基组成的环化蛋白;(a3)序列7所示的环化蛋白;(a4)将(a1)或(a2)或(a3)经过个或几个氨基酸残基的取代和/或缺失和/或添加且具有预防和/或治疗辐射损伤功能的环化蛋白。本发明还保护蛋白CAA′在制备产品中的应用;产品的功能为(f1)和/或(f2):(f1)预防和/或治疗辐射损伤;(f2)活化NF?κB信号通路。本发明对于辐射损伤的预防和/或治疗具有重大的应用前景和推广价值。



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IMMUNOGENIC COMPOSITION

Nº publicación: BR112013010338A2 02/08/2016

Solicitante:
GLAXOSMITHKLINE BIOLOG SA [BE]

Resumen de: WO2012055951A2

The present invention relates to the use of a immunogenic or immunostimulatory composition comprising a Shigella outer membrane protein (OMP) and Shigella LPS molecule in medicine and methods for preparing the composition.



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NOVEL MUCOSAL ADJUVANTS AND DELIVERY SYSTEMS

Nº publicación: HK1214507A1 29/07/2016

Solicitante:
THE BOARD OF TRUSTEES OF THE UNIV OF ARKANSA [US]

Resumen de: WO2014070709A1

Adjuvants comprising chitosan cross-linked with, an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used, in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.



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DEVICE FOR RAPID DETECTION OF INFECTIOUS AGENTS

Nº publicación: NZ626701A 29/07/2016

Solicitante:
FUNDAMENTAL SOLUTIONS CORP

Resumen de: US2013149775A1

A portable system for real time detection of the presence of an infectious agent in a biological sample employs a reagent which detects the presence of a specific infectious agent in the sample, and emits a detectable signal when the reagent reacts with the sample and detects the presence of the infectious agent. A test cartridge has a reaction chamber for receiving the sample and the reagent. The reaction chamber has a predetermined internal geometry and at least one inner surface. Introducing the sample and the reagent into the test cartridge mixes the sample and the reagent. A testing unit receives the test cartridge, and includes a sensor for detecting an emitted detectable signal. The detection of the emitted detectable signal is indicative of the presence of the infectious agent in the sample.



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METHODS OF IMPROVING THE THERAPEUTIC EFFICACY AND UTILITY OF ANTIBODY FRAGMENTS

Nº publicación: US2016215041A1 28/07/2016

Solicitantes:
HALL J CHRISTOPHER [CA]
MCLEAN MICHAEL D [CA]
XIE XUEMEI [CA]
WEISSER NINA [CA]
ALMQUIST KURT C [CA]

Resumen de: WO2010051635A1

The present disclosure relates to methods and uses of improving the therapeutic efficacy and utility of antibody fragments by employing anti-epitope-tagging technologies.



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IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS

Nº publicación: SG10201604175XA 28/07/2016

Solicitante:
QU BIOLOG INC [CA]

Resumen de: WO2012012874A1

The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.



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Rapid Method For Detection of Salmonella Live Vaccine Strains

Nº publicación: US2016215323A1 28/07/2016

Solicitante:
INTEGRATED MICROSYSTEMS FOR QUALITY OF LIFE S L [ES]

Resumen de: US2016215323A1

The present specification discloses methods of detecting a pathogen of interest, components useful in carrying out these methods, including a pre-enrichment media, and enrichment media and a detection solution and kits thereof.



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SALMONELLA ENTERICA PRESENTING C. JEJUNI N-GLYCAN OR DERIVATIVES THEREOF

Nº publicación: US2016213770A1 28/07/2016

Solicitante:
EIDGE-NOESSISCHE TECHNISCHE HOCHSCHULE ZURICHE [CH]

Resumen de: WO2010108682A1

The present invention relates to Salmonella entehca comprising at least one pgl operon of Campylobacter jejuni or a functional derivative thereof and presenting at least one N- glycan of Campylobacter jejuni or N-glycan derivative thereof on its cell surface. In addition, it is directed to medical uses and pharmaceutical compositions thereof as well as methods for treating and/or preventing Campylobacter and optionally Salmonella infections and methods for producing these Salmonella strains.



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PHAGE-BASED BACTERIAL DETECTION ASSAY

Nº publicación: JP2016521996A 28/07/2016

Resumen de: WO2014205221A2

Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.



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IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS

Nº publicación: CN105797145A 27/07/2016

Resumen de: WO2012012874A1

The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.



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A BACTERIAL VACCINE AND METHODS FOR MANUFACTURE THEREOF

Nº publicación: US2016206721A1 21/07/2016

Solicitante:
BHARAT BOTECH INTERNAT LTD [IN]

Resumen de: WO2015029056A1

Disclosed are stable conjugate vaccine formulations for protection against Salmonella typhi, and methods of conjugation between Vi-polysaccharide of S.typhi to tetanus toxoid as the carrier protein, responsible for producing improved T-dependent immune response against Typhoid fever caused by Salmonella typhi. The methods disclosed in this invention and the resulting formulations are capable of inducing immunity against typhoid fever including in children below 2 years of age, through only a single injection to comprise a complete vaccination schedule.



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USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER

Nº publicación: US2016206690A1 21/07/2016

Solicitante:
CLEVELAND BIOLABS INC [US]

Resumen de: WO2012097012A1

The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.



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CELL-PENETRATING BACTERIAL E3-UBIQITIN-LIGASES FOR USE IN IMMUNOTHERAPY

Nº publicación: US2016206713A1 21/07/2016

Solicitante:
UNIV MUENSTER WILHELMS [DE]

Resumen de: WO2015040215A1

The present invention relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for use in immunotherapy. The present invention further relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for delivering cargo molecules into eukaryotic cells.



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PASTEURIZATION ENABLING IMPROVED VIRAL AND BACTERIAL INACTIVATION LEVELS OF IN-SHELL CHICKEN EGGS WITHOUT LOSS OF RAW CHARACTERISTICS

Nº publicación: WO2016115501A1 21/07/2016

Solicitante:
DAVIDSON L JOHN [US]

Resumen de: WO2016115501A1

There is a process which can pasteurize in-shell chicken eggs to inactivate pathogens when present which includes all strains of salmonella and all strains of viruses that historically have been known to exist within chicken eggs and currently are known to be evolving into new and separate strains which may cause large quantities of human illnesses unless countermeasures are developed and employed. One such countermeasure is provided through pasteurization of the subject in-shell eggs through pasteurization involving concurrently a secured environment together with a protocol which enables total inactivation of the targeted pathogens whether bacterial or viral without risk of recontamination.


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