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Resultados 24 resultados LastUpdate Última actualización: 30/05/2016 [19:26:00] pdf PDF




Solicitudes de Patente publicadas en los últimos 90 días / Patent Applications last 90 days publications



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COMPOSITIONS AND METHODS FOR DIAGNOSING, PREVENTING, AND TREATING SALMONELLA TYPHI AND SALMONELLA PARATYPHI INFECTION

Nº publicación: US2016144013A1 26/05/2016

Solicitante:
UNIV YALE [US]

Resumen de: WO2014189942A2

The invention provides compositions and methods for preventing, treating and diagnosing infection by Salmonella enterica serovar typhi (S. typhi) and/or S. paratyphi, i.e., typhoid fever.



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MULTIFUNCTIONAL NANOPROBE-ENABLED CAPTURE AND EARLY DETECTION OF MICROBIAL PATHOGENS

Nº publicación: US2016146813A1 26/05/2016

Solicitante:
UNIV JOHNS HOPKINS [US]

Resumen de: US2016146813A1

The presently disclosed fluidic sensor system and method comprise multifunctional nanoprobe-enabled capture for early detection of chemical and/or biological pathogens in a liquid sample. This sensor system and method can be used for food and environmental monitoring.



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CHEMICAL MITIGANTS IN ANIMAL FEED AND FEED INGREDIENTS

Nº publicación: WO2016081716A1 26/05/2016

Solicitante:
UNIV KANSAS STATE [US]

Resumen de: WO2016081716A1

Methods of preventing or decreasing PEDv and/or Salmonella bacteria in animal feed, feed ingredients, and pet food are provided. The methods utilize generally safe chemical mitigants, such as medium chain fatty acids, essential oils, and sodium bisulfate. The chemical mitigants are introduced to the feed or feed ingredients at inclusion rates selected so as to prevent or decrease PEDv and/or Salmonella bacteria in the animal feed, feed ingredients, or pet food. The methods are particularly suitable for use in post-processing treatment of animal feed, feed ingredients, or pet food that will be transported and stored for multiple days or weeks.



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LPS VACCINE

Nº publicación: RU2014138021A 20/05/2016

Resumen de: EP2829281A1

A vaccine composition for birds comprising as an active ingredient a structure containing 0-antigen derived from Gram-negative bacteria, provided that said structure does not contain a whole cell, and a process for preparing the same are provided. By using a structure containing 0-antigen (e.g. lipopolysaccharide) derived from Gram-negative bacteria as an active ingredient in accordance with the present invention, alleviation of inoculation reaction and reduction in an amount of injection are attained as compared to the conventional whole -cells vaccine to thereby allow for the increase in the number of other antigens to be mixed therewith.



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PROBIOTIC BACTERIA FOR THE PREVENTION AND TREATMENT OF SALMONELLA

Nº publicación: WO2016077453A1 19/05/2016

Solicitante:
OHIO STATE INNOVATION FOUNDATION [US]

Resumen de: WO2016077453A1

As disclosed herein, fructose-asparagine (F-Asn) is a primary nutrient utilized during Salmonella-mediated gastroenteritis. Engineered bacteria are disclosed that can compete with Salmonella for F-Asn and other nutrients and withstand Salmonella-induced inflammation. These bacterium can be used as probiotics to treat and prevent Salmonella-mediated gastroenteritis.



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Protein matrix vaccines and methods of making and administering such vaccines

Nº publicación: US2016136257A1 19/05/2016

Solicitante:
HARVARD COLLEGE [US]

Resumen de: US2008095803A1

The invention relates to vaccine compositions having a carrier protein and an antigen of interest entrapped in a complex, methods of making such vaccines, and methods of vaccine administration.



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AN ISOLATED IMMUNOGENIC BACTERIAL ANTIGEN AND ITS USE IN THE PREVENTION AND TREATMENT OF INFECTIONS CAUSED BY GRAM-NEGATIVE BACTERIA

Nº publicación: US2016136285A1 19/05/2016

Solicitante:
WROCLAWSKIE CT BADAN EIT & SP Z O O [PL]

Resumen de: WO2014195880A1

The subject of the present invention is an isolated antigen being an immunogenic form of the common enterobacterial antigen (ECA) of Gram-negative bacteria of the family Enterobacteriaceae: ECA combined with lipopolysaccharide (ECALPS); a glycoconjugate of inactivated form of this antigen with a protein, as well as compositions and vaccines containing such an antigen/glycoconjugate designed for the prevention and treatment infections caused by Gram-negative bacteria.



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Polysaccharide-protein conjugate vaccines

Nº publicación: US2016136256A1 19/05/2016

Solicitante:
US HEALTH [US]

Resumen de: US2007141084A1

Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.



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COMPETITIVE IMMUNOASSAY TEST SYSTEM FOR DETECTING A PYROGEN

Nº publicación: DE102014223430A1 19/05/2016

Solicitante:
FRAUNHOFER-GESELLSCHAFT ZUR F\u00D6RDERUNG DER ANGEWANDTEN FORSCHUNG E V [DE]

Resumen de: EP3020824A1

Die Erfindung betrifft ein kompetitives Immunassay-Testsystem sowie ein Verfahren zum einfachen und schnellen Nachweis von in einer Probe enthaltenen Pyrogenen mittels der Pyrogen-Bindedomäne von Mustererkennungsrezeptoren. Das Testsystem umfasst einen Assayträger, aufweisend mindestens eine immobilisierte Pyrogen-Bindedomäne eines Mustererkennungsrezeptors mit einem markierten, verdrängbaren Liganden, wobei die Verdrängung des Liganden durch ein in der Probe enthaltenes Pyrogen durch eine Farbreaktion der Markierung angezeigt wird. Bevorzugt weist der Assayträger weiterhin mindestens ein immobilisiertes Ligandenfängerprotein auf, welches den verdrängten Liganden bindet und dadurch eine Farbreaktion der Markierung auslöst.



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DEVICES, SYSTEMS, AND METHODS FOR THE DETECTION OF ANALYTES

Nº publicación: WO2016073977A1 12/05/2016

Solicitante:
PROTEOSENSE [US]

Resumen de: WO2016073977A1

Disclosed are devices, systems, and methods for the rapid and accurate detection of analytes, including Salmonella.



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CELL-PENETRATING BACTERIAL E3-UBIQITIN-LIGASES FOR USE IN IMMUNOTHERAPY

Nº publicación: AU2014322988A1 12/05/2016

Solicitante:
UNIV MUENSTER WILHELMS

Resumen de: WO2015040215A1

The present invention relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for use in immunotherapy. The present invention further relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for delivering cargo molecules into eukaryotic cells.



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Delivering functional nucleic acids to mammalian cells via bacterially derived, intact minicells

Nº publicación: US2016113883A1 28/04/2016

Solicitante:
ENGENELC MOLECULAR DELIVERY PTY LTD [AU]

Resumen de: CN101072876A

Intact bacterially derived minicells containing functional nucleic acids or plasmids encoding functional nucleic acids can reduce, in targeted mammalian cells, drug resistance, apoptosis resistance, and neoplasticity, respectively. Methodology that employs minicells to deliver functional nucleic acids, targeting the transcripts of proteins that contribute to drug resistance or apoptosis resistance, inter alia, can be combined with chemotherapy to increase the effectiveness of the chemotherapy.



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COMPOSITIONS, KITS, AND RELATED METHODS FOR DETECTING AND/OR MONITORING SHIGA TOXIN PRODUCING ESCHERICHIA COLI

Nº publicación: US2016115527A1 28/04/2016

Solicitante:
ROKA BIOSCIENCE INC [US]

Resumen de: US2016115527A1

The invention relates to a method for testing a sample for the presence of a pathogenic Escherichia coli, the method including detecting the presence of (i) ecf and (ii) wzx and/or stx in the sample, wherein detection of (i) ecf and (ii) wzx and/or stx in the sample is taken as an indication that the sample includes pathogenic E. coli.



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COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES

Nº publicación: US2016114025A1 28/04/2016

Solicitantes:
UNIV ARKANSAS [US]
TEXAS A & M UNIV SYS [US]

Resumen de: WO2008036675A2

Provided herein are Salmonella enteritidis 13A strains and compositions comprising these strains. Also provided are methods of enhancing an immune response against Influenza A and methods of reducing morbidity associated with an Influenza A infection. Methods of enhancing an immune response to a vaccine vector by expressing a polypeptide of CD 154 capable of binding CD40 are also disclosed. Methods of developing a bacterial vaccine vector are disclosed. Methods of generating scarless site-specific mutations in a bacterium are also disclosed.



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A BACTERIAL VACCINE AND METHODS FOR MANUFACTURE THEREOF

Nº publicación: KR20160045829A 27/04/2016

Resumen de: WO2015029056A1

Disclosed are stable conjugate vaccine formulations for protection against Salmonella typhi, and methods of conjugation between Vi-polysaccharide of S.typhi to tetanus toxoid as the carrier protein, responsible for producing improved T-dependent immune response against Typhoid fever caused by Salmonella typhi. The methods disclosed in this invention and the resulting formulations are capable of inducing immunity against typhoid fever including in children below 2 years of age, through only a single injection to comprise a complete vaccination schedule.



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CN105524862A

Nº publicación: CN105524862A 27/04/2016

 

PHAGE-BASED BACTERIAL DETECTION ASSAY

Nº publicación: CN105531382A 27/04/2016

Resumen de: WO2014205221A2

Methods of detecting target bacteria are provided. In some embodiments the methods comprise exposing the sample to a phage capable of infecting a set of target bacteria and comprising a heterologous nucleic acid sequence encoding a marker. In some embodiments the target bacteria comprise Listeria. In some embodiments the target bacteria are all Listeria. Recombinant Listeria phage comprising a heterologous nucleic acid sequence encoding a marker are also provided as are useful combinations of such phage and articles of manufacture comprising such phage, among other things.



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CAU130028 Novel bacteriophage CAU130028 having killing activity specific to Salmonella Enteritidis

Nº publicación: KR20160044637A 26/04/2016

 

MDR E. COLI SPECIFIC ANTIBODY

Nº publicación: JP2016511633A 21/04/2016

Resumen de: WO2014111516A1

The subject relates to an isolated antibody that specifically binds to O25b antigen of multi drug resistant (MDR) E. coli strains, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated epitope recognized the specific antibody.



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Drug-resistant microbe and variant microbe disinfectant containing chlorous acid aqueous solution

Nº publicación: US2016106106A1 21/04/2016

Solicitante:
HONBU SANKEI CO LTD [JP]

Resumen de: CN105263327A

The present invention provides microbe disinfectants, providing: Drug-resistant microbe disinfectants comprising a chlorous acid aqueous solution for inactivating microbes selected from methicillin-resistant Staphylococcus aureus, multidrug-resistant Pseudomonas aeruginosa, and vancomycin-resistant Enterococcus; and microbe disinfectants, which are made with acidity when applied to gram-negative microbes and with alkalinity when applied to gram-positive microbes. The microbes comprise at least one species of microbes selected from the group consisting of E. coli, Staphylococcus aureus, microbes of genus Bacillus, microbes of genus Paenibacillus, Pseudomonas aeruginosa, Enterococcus, Salmonella enterica, and periodontal disease microbes. The present invention is usable as a microbe disinfectant that is safe to human body and easy to handle as a microbe disinfectant for pretreatment in food processing and produces chlorous acid that generates little chlorine dioxide. The microbe disinfectant comprising a chlorous acid aqueous solution of the present invention can be utilized as a sterilizing agent, food additive, antiseptic, quasi-drug, medicine, etc.



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FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET

Nº publicación: JP2016510973A 14/04/2016

Resumen de: WO2014133197A1

The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.



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CN105483051A

Nº publicación: CN105483051A 13/04/2016

 

CN105483052A

Nº publicación: CN105483052A 13/04/2016

 

CN105483049A

Nº publicación: CN105483049A 13/04/2016


 

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