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Resultados 67 resultados LastUpdate Última actualización 28/03/2017 [16:01:00] pdf PDF




Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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SALMONELLA CHOLERAESUIS-SALMONELLA TYPHIMURIUM VACCINES

NºPublicación: WO2017048677A1 23/03/2017

Solicitante:
BOEHRINGER INGELHEIM VETMEDICA INC [US]

Resumen de: WO2017048677A1

The present invention relates methods of reducing fecal shedding of animals infected with Salmonella by use of a vaccine or immunogenic composition of Salmonella Choleraesuis-Typhimurium.



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Device For Detection Of Target Molecules And Uses Thereof

NºPublicación: US2017082613A1 23/03/2017

Solicitante:
INVISIBLE SENTINEL INC [US]

Resumen de: US2017082613A1

Devices and methods for the detection of antigens are disclosed. Devices and methods for detecting food-borne pathogens are disclosed.



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FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF

NºPublicación: US2017080051A1 23/03/2017

Solicitante:
CLEVELAND CLINIC FOUND [US]

Resumen de: US2017080051A1

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.



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COMPOSITIONS PRODUCED USING ENTERIC PATHOGENS AND METHODS OF USE

NºPublicación: US2017080073A1 23/03/2017

Solicitante:
EPITOPIX LLC [US]

Resumen de: US2017080073A1

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.



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COMPOSITIONS PRODUCED USING ENTERIC PATHOGENS AND METHODS OF USE

NºPublicación: US2017080074A1 23/03/2017

Solicitante:
EPITOPIX LLC [US]

Resumen de: US2017080074A1

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.



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TUMOR ASSOCIATED VACCINES AND COMPOSITIONS FOR DISRUPTING TUMOR-DERIVED IMMUNOSUPPRESSION FOR USE IN COMBINATION CANCER IMMUNOTHERAPY

NºPublicación: US2017081671A1 23/03/2017

Solicitante:
HOPE CITY [US]

Resumen de: US2017081671A1

In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided. Such a therapeutic composition may include a Salmonella strain comprising a plasmid that expresses an shRNA molecule that suppresses the expression of an immunosuppressive target and suppresses tumor growth. In some aspects, the Salmonella strain is an attenuated Salmonella typhimurium strain. In other aspects, the immunosuppressive target is STAT3, IDO1, IDO2, Arginase 1, iNOS, CTLA-4, TGF-β, IL-10, pGE2 or VEGF. In one embodiment, the immunosuppressive target is IDO1 or Arg1 and the shRNA molecule is any one of SEQ ID NO:5-14.



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Compositions And Methods For Immunodominant Antigens

NºPublicación: US2017081659A1 23/03/2017

Solicitante:
IMMPORT THERAPEUTICS INC [US]

Resumen de: US2017081659A1

Contemplated compositions, devices, and methods comprise immunodominant antigens from selected human pathogens (Burkholderia pseudomallei, Borrelia burgdorferi, Brucella melitensis, Chlamydia muridarum, Coxiella burnetii, Francisella tularensis, human Herpes virus 1 and 2, Mycobacterium tuberculosis, Plasmodium falciparum, and Vaccinia virus) can be used as a vaccine, as diagnostic markers, and as therapeutic agents. In particularly preferred aspects, the antigens have quantified and known relative reactivities with respect to sera of a population infected with the pathogen, and have a known association with a disease parameter.



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COMPOSITIONS PRODUCED USING ENTERIC PATHOGENS AND METHODS OF USE

NºPublicación: US2017080072A1 23/03/2017

Solicitante:
EPITOPIX LLC [US]

Resumen de: US2017080072A1

The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.



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种沙门氏菌鞭毛融合蛋白及其编码基因和应用

NºPublicación: CN106519039A 22/03/2017

Resumen de: CN106519039A

本发明涉及基因工程技术领域,具体地,本发明涉及种沙门氏菌鞭毛融合蛋白及其编码基因和应用。本发明的沙门氏菌鞭毛融合蛋白FliC‑CTB,其氨基酸序列如SEQ ID NO.1所示。本发明的基因fliC‑CTB,编码上述沙门氏菌鞭毛融合蛋白FliC‑CTB,其碱基序列如SEQ ID NO.2或3所示。本发明利用植物遗传转化技术,将沙门氏菌fliC基因与霍乱肠毒素B亚基基因融合转入马铃薯,筛选获得转基因植株,并在分子水平上证实了目的基因的整合、转录和表达,过对植物外源融合蛋白检测,证明融合蛋白具有抗原活性,利用本发明的融合基因植物表达载体可将马铃薯作为生物反应器表达该融合蛋白。也可通过本发明继续研发沙门氏菌“通用植物口服疫苗”,为沙门氏菌病防治提供种新的有效的解决途径。



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Method to Introduce Salmonella Into Ground Meat

NºPublicación: US2017074862A1 16/03/2017

Solicitante:
TEXAS TECH UNIV SYSTEM [US]
UNITED STATES DEPT OF AGRICULTURE [US]

Resumen de: US2017074862A1

The present invention includes a method of introducing a pathogenic infection into one or more peripheral lymph nodes of an animal for testing of meat, comprising: inoculating at one or more peripheral lymph node drainage areas the animal with a known amount of a known pathogen; harvesting one or more peripheral lymph nodes from the animal; grinding meat or meat trimmings and the one or more peripheral lymph nodes into ground meat; and determining a ratio of a number of peripheral lymph nodes infected to the weight of the meat or meat trimmings used to create the ground meat, wherein the infected ground meat can be used to test interventions against the known pathogen in a grinding process.



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SALMONELLA CHOLERAESUIS-SALMONELLA TYPHIMURIUM VACCINES

NºPublicación: US2017072042A1 16/03/2017

Solicitante:
BOEHRINGER INGELHEIM VETMEDICA INC [US]

Resumen de: US2017072042A1

The present invention relates methods of reducing fecal shedding of animals infected with Salmonella by use of a vaccine or immunogenic composition of Salmonella Choleraesuis-Typhimurium.



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Methods and compositions for intra-nasal immunization with recombinant MVA encoding flagellin

NºPublicación: AU2015323736A1 16/03/2017

Solicitante:
BAVARIAN NORDIC AS

Resumen de: AU2015323736A1

Provided herein are immunogenic compositions comprising a recombinant modified vaccinia virus Ankara (MVA) comprising a nucleic acid sequence encoding a flagellin, and a nucleic acid sequence encoding a heterologous disease-associated antigen, wherein the immunogenic composition induces increased T-cell and antibody mediated immune responses specific for the heterologous disease-associated antigen when administered to a subject, e.g. a human subject, and related methods and uses.



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Flagellin-based agents and uses including effective vaccination

NºPublicación: AU2015296298A1 16/03/2017

Solicitante:
CLEVELALND BIOLABS INC\n

Resumen de: AU2015296298A1

The present invention relates to, in part, compositions comprising improved flagellin derived constructs and methods of using for vaccination, including adjuvants comprising flagellin-based agents.



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种肠炎沙门菌基因敲除减毒突变株及其制备与应用

NºPublicación: CN106497855A 15/03/2017

Resumen de: CN106497855A

�x672C;发明属于微生物领域,具体涉及种肠炎沙门菌基因敲除减毒突变株及其制备与应用。本发明首先提供种肠炎沙门菌基因敲除减毒株,为基因不表达的肠炎沙门菌。本发明成功研制了种肠炎沙门菌基因敲除减毒株,本发明通过动物试验发现,所述突变株毒力显著降低,对强毒力肠炎沙门菌提供良好的保护作用,可有效清除强毒力菌株感染。



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种淋病奈瑟菌‑沙门菌双效疫苗、制备方法及应用

NºPublicación: CN106492211A 15/03/2017

Resumen de: CN106492211A

本发明提供种淋病奈瑟菌‑沙门菌双效疫苗,其中,沙门菌菌影作为递送载体负载淋病奈瑟菌PorB DNA疫苗;以及其制备方法和应用。主要包括以下步骤:1)以淋病奈瑟菌基因组为模板,通过PCR扩增出孔蛋白B(PorB)基因并构建PorB DNA疫苗;2)构建温控表达载体pB‑E,并将其转化到沙门菌感受态中获得重组菌SE(pB‑E),经温度诱导制得沙门菌菌影疫苗冻干粉;3)将淋病奈瑟菌PorB DNA疫苗与沙门菌菌影冻干粉孵育,得到沙门菌菌影负载的淋病奈瑟菌PorB的菌影疫苗SE ghost(PorB)。该双效疫苗安全性良好、能同时诱导机体产生和提高针对淋病奈瑟菌和沙门菌的特异性体液免疫应答、黏膜免疫应答,并具有较高的抗体水平;在淋病和/或沙门菌防治方面具有重大意义。



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APPLICATION OF GENETIC ENGINEERING BACTERIUM OF ATTENUATED SALMONELLA TYPHIMURIUM IN PREPARATION OF MEDICINE FOR TREATING LIVER CANCER

NºPublicación: WO2017036302A1 09/03/2017

Solicitante:
NANJING SINOGEN BIOTECH & PHARMACEUTICAL INC [CN]

Resumen de: WO2017036302A1

Provided is an application of a genetic engineering bacterium of attenuated Salmonella typhimurium in preparation of medicine for treating liver cancer. The bacterium is attenuated Salmonella typhimurium VNP20009 carrying a plasmid cloned with a methionine synthase gene. Also provided is a construction method for the bacterium.



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SWINE VIRUS VACCINES THAT ARE LIQUID STABLE

NºPublicación: JP2017506643A 09/03/2017

Resumen de: WO2015124594A1

The present invention is drawn to liquid stable swine vaccines that comprise a live porcine virus. The invention is also drawn to the manufacture of such vaccines and methods of vaccinating animal subjects with these vaccines.



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METHOD AND DEVICE FOR DETECTION OF PSEUDOMONAS AERUGINOSA

NºPublicación: US2017067894A1 09/03/2017

Solicitante:
YISSUM RES DEV COMPANY OF THE HEBREW UNIV OF JERUSALEM LTD [IL]
YEDA RES & DEV [IL]

Resumen de: US2017067894A1

A method of and device for detecting and diagnosing Pseudomonal aeruginosa in a gaseous, liquid or solid sample, employing Lux-R-like receptor-driven reporter cells.



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PHAGE WRAPPING

NºPublicación: US2017067026A1 09/03/2017

Solicitante:
UNIV CALIFORNIA [US]

Resumen de: US2017067026A1

Disclosed herein, inter alia, are compositions and methods useful for improving detection of analytes. The compositions and methods provided include polymer-wrapped viral particles useful, inter alia, for the detection of PSMA.



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USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER

NºPublicación: US2017065692A1 09/03/2017

Solicitante:
CLEVELAND BIOLABS INC [US]

Resumen de: US2017065692A1

The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.



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COMPOSITION FOR ORAL DELIVERY OF BIOACTIVE AGENTS

NºPublicación: DK201670506A1 06/03/2017

Solicitante:
ADVANCED BIONUTRITION CORP [US]

Resumen de: DK201670506A1

A composition for oral administration of a bioactive agent to aquatic or terrestrial species includes particles each of which includes a bioactive agent dispersed in oil droplets, the oil droplets being dispersed in a matrix including an enteric coating polymer, wherein the particles each further include a mucoadhesive polymer. Methods of making and using the composition are also provided.



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Method of Treating Protozoal Gastrointestinal Disorders in Immunocompromised Patients

NºPublicación: US2017056497A1 02/03/2017

Solicitante:
WHELIHAN JOSEPH [US]
ELEY JADA [US]

Resumen de: US2017056497A1

The invention relates to a method for treating protozoal gastrointestinal disorders in immunocompromised patients. It includes a method for the isolation of a factor from the milk of hyperimmunized animals in a substantially pure form, and to the use of said factor in combination with vitamins and minerals.



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ALGAL BASED EDIBLE VACCINES

NºPublicación: JP2017506212A 02/03/2017

Resumen de: WO2015121863A1

The present invention provides edible vaccines comprising transgenic microalgae expressing at least one exogenous antigen or an intervening organism comprising the transgenic microalgae. The antigen expressing microalgae are used for oral delivery of the antigen to a target organism in its intact and functional form. The exogenous antigen, expressed in the microalgae, is characterized by exerting at least one immunogenic response in the subject consuming the vaccine.



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METHODS AND SYSTEMS FOR ELECTROCHEMICALLY DETECTING OR QUANTIFYING AN ANALYTE

NºPublicación: US2017059567A1 02/03/2017

Solicitante:
THE UNIV OF UTAH RES FOUND [US]

Resumen de: US2017059567A1

Methods of electrochemically detecting or quantifying an analyte by coupling a plurality of redox-active agents (e.g., guanine-rich oligonucleotides) to the analyte are disclosed. More particularly, this application discloses affinity-based methods for isolating one or more analytes from a sample and subsequently detecting or determining the concentration of the one or more analytes. Detecting or determining the concentration of one or more analytes may involve measuring the extent of oxidation of guanine nucleobases that have been or are coupled to the analyte.



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FLAGELLAR AND NEEDLE COMPLEX (INJECTOSOME) LOOP AS ANTI BACTERIAL DRUG TARGET

Nº publicación: US2017049779A1 23/02/2017

Solicitante:
OKINAWA INST OF SCIENCE AND TECH SCHOOL CORP [JP]

Resumen de: US2017049779A1

The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.


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