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Resultados 58 resultados LastUpdate Última actualización 09/12/2016 [03:38:00] pdf PDF




Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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AUTOMATED ASSAY

NºPublicación: EP3099409A2 07/12/2016

Solicitante:
UNIV STRATHCLYDE [GB]

Resumen de: WO2015114316A2

Disclosed is a system and method for automating the performance of a conjugate or sandwich assay, and a cassette for use with the system. The cassette comprises a fluid conduit and one or more chambers in the fluid conduit, from which a measurement may be acquired from a sample using a cassette reader device. Sample and reagent fluids may be caused to flow along the fluid conduit to perform the assay and control over the progress of the assay may be exerted at least in part by the arrangement of chambers in the fluid conduit. Also disclosed is a tablet or bead for use with the assay system, which may be incorporated in the cassette. The tablet or bead may comprise one or more reagents to be used in the assay, in a soluble matrix. Use of an acridan or acridinium ester label may enable a sensitive measurement to be rapidly acquired. The assay may be configured to be performed by a clinician at the point of use or care.



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ALGAL BASED EDIBLE VACCINES

NºPublicación: US2016346373A1 01/12/2016

Solicitante:
TRANSALGAE ISRAEL LTD [IL]

Resumen de: US2016346373A1

Provided are edible vaccines including transgenic microalgae expressing at least one exogenous antigen or an intervening organism including the transgenic microalgae. The antigen expressing microalgae are used for oral delivery of the antigen to a target organism in its intact and functional form. The exogenous antigen, expressed in the microalgae, is characterized by exerting at least one immunogenic response in the subject consuming the vaccine.



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COMPOSITIONS AND METHODS OF ENHANCING IMMUNE RESPONSES TO EIMERIA

NºPublicación: EP3097926A1 30/11/2016

Solicitante:
UNIV ARKANSAS [US]
TEXAS A & M UNIV SYS [US]
UNIV GUELPH [CA]

Resumen de: EP3097926A1

Vaccines comprising TRAP polypeptides and Salmonella enteritidis vectors comprising TRAP polypeptides are provided. The vaccines may also include a CD 154 polypeptide capable of binding to CD40. Also provided are methods of enhancing an immune response against Apicomplexan parasites and methods of reducing morbidity associated with infection with Apicomplexan parasites.



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COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGEN NUCLEIC ACID

NºPublicación: EP3098323A1 30/11/2016

Solicitante:
GEN PROBE PRODESSE INC [US]

Resumen de: EP3098323A1

Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and combinations thereof, for determining the presence or absence of at least two of Salmonella, Shigella, C. jejuni, and C. coli. Also disclosed are methods of specific nucleic acid amplification and detection, including multiplex assays, using the disclosed oligomers, as well as corresponding reaction mixtures and kits.



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VACCINES FOR USE IN THE PROPHYLAXIS AND TREATMENT OF INFLUENZA VIRUS DISEASE

NºPublicación: JP2016196472A 24/11/2016

Resumen de: WO2011103453A2

Provided herein are polypeptides comprising portions of the influenza virus hemagglutinin, compositions comprising such polypeptides that can be used as immunogens in vaccines and methods of their use to generate an immune response against multiple influenza subtypes in a subject.



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Salmonella conjugate vaccines

NºPublicación: JP2016536317A 24/11/2016

Resumen de: EP2870974A1

The invention relates to a conjugate based on Vi polysaccharide which is fragmented and a carrier protein, to compositions comprising said conjugate and to methods for making said conjugates and compositions.



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BACTERIAL LIVE VECTOR VACCINES EXPRESSING CHROMOSOMALLY-INTEGRATED FOREIGN ANTIGENS

NºPublicación: US2016339095A1 24/11/2016

Solicitante:
GALEN JAMES E [US]
WANG JIN-YUAN [US]
UNIV MARYLAND [US]

Resumen de: US2016339095A1

Bacterial live vector vaccines represent a vaccine development strategy that offers exceptional flexibility. In the present invention, genes encoding protective antigens of unrelated bacterial, viral, parasitic, or fungal pathogens are expressed in an attenuated bacterial vaccine strain that delivers these foreign antigens to the immune system, thereby eliciting relevant immune responses. Rather than expressing these antigens using only low copy expression plasmids, expression of foreign proteins is accomplished using both low copy expression plasmids in conjunction with chromosomal integrations within the same live vector. This strategy compensates for the inherent disadvantage of loss of gene dosage (versus exclusive plasmid-based expression) by integrating antigen expression cassettes into multiple chromosomal sites already inactivated in an attenuated vector.



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ENRICHMENT AND SELECTIVE CULTURE OF SALMONELLA AND SHIGELLA

NºPublicación: WO2016181070A1 17/11/2016

Solicitante:
BIOM\u00C9RIEUX [FR]

Resumen de: WO2016181070A1

The invention relates to the detection and identification of bacteria of the genera Salmonella and Shigella. More specifically, it relates to the methods of microbiology and the culture media used for the detection, identification, isolation and/or analytical study of said bacteria. The invention further relates to a method for the enrichment and selective culture of bacteria of the genera Salmonella and/or Shigella contained in a biological sample. In said method, all or part of said sample is seeded in/on a culture medium comprising a nutritive component favourable to the development and growth of said bacteria, and comprising L-ornithine as a selective agent. The invention also relates to a culture medium for implementing said method.



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免疫原性抗炎症組成物

NºPublicación: JP2016193902A 17/11/2016

Resumen de: JP2016193902A

【課題】特定の器官又は組織における炎症性状態を処置するための抗炎症組成物を処方する方法の提供。【解決手段】特定の器官又は組織において病原性である少なくとも1の病原体を選択するステップと、病原体について一緒に特異的である抗原決定基を含む抗原性組成物を生成するステップと、特定の器官又は組織において抗炎症応答を誘発できる抗炎症組成物として投与するために抗原性組成物を処方するステップとを含み、炎症を特徴とする状態はがんでない方法。抗原性組成物を生成する前に、炎症の症状を示す特定の器官又は組織を同定する診断ステップを更に含む特定の器官又は組織に腫瘍がある。抗原性組成物は、皮下注射又は皮内注射用に処方される方法。【選択図】なし



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Phage Therapy of E coli infections

NºPublicación: EP3091992A1 16/11/2016

Solicitante:
PHERECYDES PHARMA [FR]

Resumen de: EP2893933A1

The present invention relates to bacteriophage therapy. More particularly, the present invention relates to novel bacteriophages having a high specificity against Escherichia coli strains, their manufacture, components thereof, compositions comprising the same and the uses thereof in phage therapy.



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Shell Egg Pasteurization Using Radio Frequency Electromagnetic Wave Energy

NºPublicación: US2016324170A1 10/11/2016

Solicitante:
NAT PASTEURIZED EGGS INC [US]

Resumen de: US2016324170A1

A shell egg pasteurization system uses radio frequency electromagnetic wave energy to heat the yolk. The radio frequency energy is applied in two stages as the shell egg is rotated and moved through the electric field. The system also has a preheating oven and a downstream albumen heating oven. The combination of heat from the ovens and the radio frequency is sufficient to achieve a 5 log kill of Salmonella Enteritidis throughout the eggs.



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SHELL EGG PASTEURIZATION USING RADIO FREQUENCY ELECTROMAGNETIC WAVE ENERGY

NºPublicación: WO2016179210A1 10/11/2016

Solicitante:
NAT PASTEURIZED EGGS INC [US]

Resumen de: WO2016179210A1

A shell egg pasteurization system uses radio frequency electromagnetic wave energy to heat the yolk. The radio frequency energy is applied in two stages as the shell egg is rotated and moved through the electric field. The system also has a preheating oven and a downstream albumen heating oven. The combination of heat from the ovens and the radio frequency is sufficient to achieve a 5 log kill of Salmonella Enteritidis throughout the eggs.



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AUTOMATED WAX SPRAYER SYSTEM FOR CLEAN, WASHED OR PASTEURIZED SHELL EGGS

NºPublicación: WO2016178940A1 10/11/2016

Solicitante:
NAT PASTEURIZED EGGS INC [US]

Resumen de: WO2016178940A1

An automated wax sprayer system for clean, washed or pasteurized shell eggs sprays a heated solution containing water and wax emulsion onto the eggs as they rotate and pass through a conveyer. The temperature of the wax coating on the surface of the egg shells is heated at or above a sanitizing temperature and sprayed on the surface of the egg shells where Salmonella contamination may be present. Salmonella contamination present on the surface of the egg shells is eliminated substantially immediately. Separate flow pumps provide a consistent flow of wax solution to individual nozzles for consistent application of the wax on the entire surface of the eggs.



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COMPETITIVE IMMUNOASSAY TEST SYSTEM FOR DETECTING A PYROGEN

NºPublicación: US2016327580A1 10/11/2016

Solicitante:
FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E V [DE]

Resumen de: US2016327580A1

The invention relates to a competitive immunoassay test system as well as a method to simply and rapidly detect pyrogens contained in a sample by means of the pyrogen binding domain of pattern recognition receptors. The test system comprises an assay carrier having at least one immobilized pyrogen binding domain of a pattern recognition receptor with a labeled, displaceable ligand, wherein the displacement of the ligand is indicated by a pyrogen contained in the sample by a color reaction of the labeling. The assay carrier preferably also has at least one immobilized ligand capture protein, which binds the displaced ligand and thereby initiates a color reaction of the labeling.



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Compositions and methods for detecting gastrointestinal pathogen nucleic acid

NºPublicación: AU2016247158A1 10/11/2016

Solicitante:
GEN-PROBE INCORPORATED

Resumen de: AU2016247158A1

COMPOSITIONS AND METHODS FOR DETECTING GASTROINTESTINAL PATHOGEN NUCLEIC ACID [145] Disclosed are nucleic acid oligomers, including amplification oligomers, detection probes, and combinations thereof, for detection of one or more gastrointestinal pathogens selected from Salmonella, Shigella, Campylobacter jejuni, and Campylobacter coli. Also disclosed are methods of specific nucleic acid amplification and detection, including multiplex assays, using the disclosed oligomers, as well as corresponding reaction mixtures and kits.



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PREVENTION OF CROSS-CONTAMINATION IN SYSTEMS FOR RAPID ANALYSIS OF BIOLOGICAL SAMPLES

NºPublicación: US2016327488A1 10/11/2016

Solicitante:
FUNDAMENTAL SOLUTIONS CORP [US]

Resumen de: US2016327488A1

A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a reaction chamber having a central axis, wherein the reaction chamber has the shape of a revolved half ellipse; and an inlet channel connected to the reaction chamber, wherein the inlet channel is positioned above the reaction chamber at an angle of 15-60 degrees above the horizontal, and wherein the inlet channel is offset from the central axis of the reaction chamber.



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REACTION CHAMBERS FOR USE IN SYSTEMS FOR RAPID ANALYSIS OF BIOLOGICAL SAMPLES

NºPublicación: US2016327487A1 10/11/2016

Solicitante:
FUNDAMENTAL SOLUTIONS CORP [US]

Resumen de: US2016327487A1

A system for use in rapid sample analysis that includes a biosensor reagent, wherein the biosensor reagent includes living biological cells; a reservoir card, wherein the reservoir card stores the biosensor reagent; and a test cartridge base, wherein the test cartridge base is configured to accept the reservoir card, and wherein the test cartridge base further includes a contoured reaction chamber; and an inlet channel connected to and entering the reaction chamber at a predetermined angle thereto.



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DEVICE FOR RAPID DETECTION OF INFECTIOUS AGENTS

NºPublicación: JP2016191720A 10/11/2016

Resumen de: US2013149775A1

A portable system for real time detection of the presence of an infectious agent in a biological sample employs a reagent which detects the presence of a specific infectious agent in the sample, and emits a detectable signal when the reagent reacts with the sample and detects the presence of the infectious agent. A test cartridge has a reaction chamber for receiving the sample and the reagent. The reaction chamber has a predetermined internal geometry and at least one inner surface. Introducing the sample and the reagent into the test cartridge mixes the sample and the reagent. A testing unit receives the test cartridge, and includes a sensor for detecting an emitted detectable signal. The detection of the emitted detectable signal is indicative of the presence of the infectious agent in the sample.



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NON-CODING RNA OF SALMONELLA AND IDENTIFICATION AND USE THEREOF

NºPublicación: US2016319332A1 03/11/2016

Solicitante:
JIANGSU MICROMEDMARK BIOTECH CO LTD [CN]
JIANGSU MICROMEDMARK BIOTECH CO LTD [CN]

Resumen de: US2016319332A1

The present invention provides Salmonella non-coding RNA and the identification and application thereof. In particular, the present invention proves through experiments that a Salmonella bacterium delivers non-coding RNAs (ncRNAs) encoded by the bacterium itself into a host cell, generates milRNAs similar to microRNAs by means of a microRNA splicing system in the cell, regulates the immune system with the milRNAs, and further protects the Salmonella bacterium from being cleared by the host. Adsorbing milRNAs using milRNA inhibitors can effectively inhibit the survival ability of the bacterium in the cell, leading to a reduced vitality of the bacterium. The present invention further provides relevant reagents and methods for effective detection of, treatment to and study on Salmonella bacteria or Salmonella infectious diseases.



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NOVEL MSLN TARGETING DNA VACCINE FOR CANCER IMMUNOTHERAPY

NºPublicación: US2016317634A1 03/11/2016

Solicitante:
VAXIMM GMBH MAFINEX-TECHNO-LOGIEZENTRUM [DE]
VAXIMM GMBH MAFINEX-TECHNOLOGIEZENTRUM [DE]

Resumen de: US2016317634A1

The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding Mesothelin. In particular, the present invention relates to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy.



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Automated Wax Sprayer System for Clean, Washed or Pasteurized Shell Eggs

NºPublicación: US2016316774A1 03/11/2016

Solicitante:
NAT PASTEURIZED EGGS INC [US]

Resumen de: US2016316774A1

An automated wax sprayer system for clean, washed or pasteurized shell eggs sprays a heated solution containing water and wax emulsion onto the eggs as they rotate and pass through a conveyer. The temperature of the wax coating on the surface of the egg shells is heated at or above a sanitizing temperature and sprayed on the surface of the egg shells where Salmonella contamination may be present. Salmonella contamination present on the surface of the egg shells is eliminated substantially immediately. Separate flow pumps provide a consistent flow of wax solution to individual nozzles for consistent application of the wax on the entire surface of the eggs.



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Biyo Trap

NºPublicación: US2016320277A1 03/11/2016

Solicitante:
AVCI RECEP [US]

Resumen de: US2016320277A1

A device consisting activated microfibers, such as glass and cellulose, comprising the 3D network, packed in small volumes, traps and concentrates the bacteria from trace contaminated liquids rapidly. It functions for concentrating and rapid detection of microbes in <20 min. The device enables the easy recovery of concentrated bacteria, which involves the mixing and agitation of the contaminated sample, followed by the suction. The chemistry of the system involves coupling aminosilane groups such as 3-aminopropyl methyldiethoxysilane (APMDES) or carboxylated groups in 3-triethoxysilyl propylsuccinicanhydride (TESPSA) to the —OH bearing moieties on the surfaces of glass and/or cellulose microfibers, attained by solution or vapor phase techniques. The device has a wide variety of applications, including rapid detection of trace bacteria in contaminated liquids; in vegetable, fruit, meat, tabletop and countertop wash-offs; and in the filtration of liquids (water or fuels) to remove bacteria or other microorganisms.



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Salmonella conjugate vaccines

NºPublicación: EA201690857A1 31/10/2016

Resumen de: EP2870974A1

The invention relates to a conjugate based on Vi polysaccharide which is fragmented and a carrier protein, to compositions comprising said conjugate and to methods for making said conjugates and compositions.



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CRP CAPTURE/DETECTION OF GRAM POSITIVE BACTERIA

NºPublicación: US2016311877A1 27/10/2016

Solicitante:
WATTERS ALEXANDER [US]
INGBER DONALD [US]
CARTWRIGHT MARK [US]
SUPER MICHAEL [US]
ROTTMAN MARTIN [FR]
PRESIDENT AND FELLOWS OF HARVARD COLLEGE [US]

Resumen de: US2016311877A1

Described herein are engineered microbe-targeting molecules, microbe-targeting articles, kits comprising the same, and uses thereof. Such microbe-targeting molecules, microbe-targeting articles, or the kits comprising the same can bind or capture of a microbe or microbial matter thereof, and can thus be used in various applications, such as diagnosis or treatment of an infection caused by microbes in a subject or any environmental surface.



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ENCAPSULATED SENSORS AND SENSING SYSTEMS FOR BIOASSAYS AND DIAGNOSTICS AND METHODS FOR MAKING AND USING THEM

Nº publicación: JP2016533164A 27/10/2016

Resumen de: WO2015048173A2

In alternative embodiments, the invention provides high throughput, multiplexed systems or methods for detecting a biological, a physiological or a pathological maker, or a single molecule or a single cell using a droplet microfluidics system integrated with use of a sensor or a sensing system, an aptamer, or a DNAzyme. In alternative embodiments, the sensor or sensing system comprises a nucleic acid based, an antibody based, an enzyme based or a chemical based sensor or sensing system. In alternative embodiments, the invention provides methods for detecting a biological, a physiological or a pathological marker, or a single molecule or a single cell using a droplet system integrated with rapid and sensitive fluorescence detection systems including, for example, a 3D Particle Detector. In alternative embodiments, the invention provides systems comprising Integrated Comprehensive Droplet Digital Detection (IC 3D).


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