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Resultados 60 resultados LastUpdate Última actualización 21/05/2019 [18:31:00] pdf PDF

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days

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A METHOD OF REDUCING EGG CONTAMINATION

NºPublicación: EP3463442A1 10/04/2019

Solicitante:

UNIV GENT [BE]

CN_109496156_A

Resumen de: WO2017202804A1

The present invention relates to Salmonella mutant strains and their use as a vaccine for preventing Salmonella infection, in particular in eggs.

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Artificial Invaplex Formulated with Deacylated Lipopolysaccharide

NºPublicación: US2019099442A1 04/04/2019

Solicitante:

THE US SECRETARY OF THE ARMY ON BEHALF OF THE WALTER [US]

WO_2018005324_A1

Resumen de: US2019099442A1

Disclosed herein are artificial Invaplexes comprising deacylated lipopolysaccharides and methods of making and using thereof.

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ENGINEERING GUT COMMENSAL BACTERIA TO EXPRESS HETEROLOGOUS PROTEINS IN THEIR OUTER MEMBRANE VESICLES (OMVS) FOR DELIVERY TO THE GI-TRACT

NºPublicación: US2019099477A1 04/04/2019

Solicitante:

QUADRAM INST BIOSCIENCE [GB]
UEA ENTERPRISES LTD [GB]

CN_108779482_A

Resumen de: US2019099477A1

This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.

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METHOD FOR PRODUCING BACTERIAL GHOST AND VECTOR FOR PRODUCING BACTERIAL GHOST

NºPublicación: KR20190033708A 01/04/2019

Solicitante:

NAT UNIV CHONBUK IND COOP FOUND [KR]

Resumen de: KR20190033708A

본원은, 박테리오파지의 홀린(holin) 유전자, 엔도라이신(endolysin) 유전자 및 Rz 유전자를 포함하는 카제트(cassette)를 포함하는 벡터에 의해 형질전환된 고스트 백신 균주, 이의 제조를 위한 벡터, 이를 포함하는 조성물 및 세균 고스트 제조 방법에 관한 것이다.

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PATHOGEN VACCINES AND METHODS OF PRODUCING AND USING THE SAME

NºPublicación: JP2019508418A 28/03/2019

Solicitante:

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CN_108697778_A

Resumen de: WO2017143024A2

The present invention provides vaccine compositions and methods of producing such compositions. Other embodiments of the invention include methods of treating a pathogen infection, methods of vaccinating a subject against a pathogen infection, and methods for treating an antibiotic-resistance bacterial infection in a subject in need thereof. In further embodiments, the invention includes methods of decreasing the level of a pathogen in a subject having a pathogen infection, methods of increasing the surviving rate of a subject having a pathogen infection, methods of reducing the level of pain associated with a pathogen infection, and methods of reducing the level of distress associated with a pathogen infection in a subject in need thereof. Novel scaffold compositions and opsonin-bound or lectin-bound pathogen compositions, and uses thereof, are also provided herein.

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REAGENT FOR RAPIDLY AND QUANTITATIVELY DETECTING ANTIMICROBIAL SUSCEPTIBILITY AND APPLICATION METHOD THEREOF

NºPublicación: WO2019056926A1 28/03/2019

Solicitante:

XINTRUM PHARMACEUTICALS LTD [CN]

CN_107421939_A

Resumen de: WO2019056926A1

A kit for rapidly and quantitatively detecting antimicrobial susceptibility, comprising a reagent capable of directly detecting bacterial ATP. After adding the reagent at once, lysis of bacteria and release and detection of ATP can be achieved in one step, and experimental results for antimicrobial susceptibility can be obtained in 2 hours. Any microplate type luminescence detector can be used, and an automatic sample injection system is not required. The operation for adding samples is done in one step, and there is no need to inject a lysis solution and an ATP-detecting reagent separately. An MIC value can be determined, and whether the bacteria are drug resistant is also reported.

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BACTERIALLY-DERIVED, INTACT MINICELLS THAT ENCOMPASS PLASMID-FREE FUNCTIONAL NUCLEIC ACID FOR IN VIVO DELIVERY TO MAMMALIAN CELLS

NºPublicación: US2019091160A1 28/03/2019

Solicitante:

ENGENEIC MLOECULAR DELIVERY PTY LTD [AU]
ENGENEIC MOLECULAR DELIVERY PTY LTD [AU]

US_2018028456_A1

Resumen de: US2019091160A1

Intact, bacterially-derived minicells can safely introduce therapeutically effective amounts of plasmid-free functional nucleic acid to target mammalian cells. To this end, functional nucleic acid can be packaged into intact minicells directly, without resort to expression constructs, the expression machinery of the host cell, harsh chemicals or electroporation.

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种肠炎沙门菌icdA基因缺失株及其应用

NºPublicación: CN109517776A 26/03/2019

Solicitante:

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Resumen de: CN109517776A

本发明公开了种肠炎沙门菌icdA基因缺失株及其应用,其中肠炎沙门菌icdA基因缺失株的构建方法,包括次重组菌株肠炎沙门菌c50336::cat的构建和二次重组菌株肠炎沙门菌c50336ΔicdA的构建。本发明提供了种肠炎沙门菌icdA基因缺失株的构建方法,该方法通过构建肠炎沙门菌icdA基因缺失株,并对其生物学特性和毒力进行研究,用以系统评估icdA基因对肠炎沙门菌毒力的影响,明确了icdA基因缺失引起肠炎沙门菌毒力下降,为肠炎沙门菌疫苗研究,进而防治肠炎沙门菌感染提供参考。

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牛源肠炎沙门菌nmpC基因缺失的应用

NºPublicación: CN109517773A 26/03/2019

Solicitante:

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Resumen de: CN109517773A

本发明公开了牛源肠炎沙门菌nmpC基因缺失株的构建方法,以及牛源肠炎沙门菌nmpC基因缺失能够降低牛源肠炎沙门菌的毒力,且牛源肠炎沙门菌nmpC基因缺失能够应用于肠炎沙门菌疫苗。本发明利用Red同源重组方法构建牛源肠炎沙门菌nmpC基因缺失株,并对其生物学特性和毒力进行研究,明确了nmpC基因缺失引起牛源肠炎沙门菌毒力下降,为设计牛源肠炎沙门菌疫苗靶点提供参考,进而防治肠炎沙门菌感染,同时能够进步探索肠炎沙门菌NmpC蛋白的生理学功能。

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MODIFIED NANOPORES, COMPOSITIONS COMPRISING THE SAME, AND USES THEREOF

NºPublicación: JP2019507583A 22/03/2019

Solicitante:

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CN_109072295_A

Resumen de: WO2017098322A1

Provided herein relate to modified or mutant forms of cytolysin A (ClyA) and compositions comprising the same. In particular, the modified or mutant forms of ClyA permits efficient capture and/or translocation of a target negative-charged molecule or polymer through the modified or mutant ClyA nanopores at low or physiological ionic strengths. Thus, methods for using the modified or mutant forms of ClyA and compositions, for example, for characterizing a target negatively-charged analyte, e.g., a target polynucleotide, are also provided.

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GENETIC TESTING FOR PREDICTING RESISTANCE OF SALMONELLA SPECIES AGAINST ANTIMICROBIAL AGENTS

NºPublicación: US2019085377A1 21/03/2019

Solicitante:

ARES GENETICS GMBH [AT]

CN_108271394_A

Resumen de: US2019085377A1

The invention relates to a method of determining an infection of a patient with Salmonella species potentially resistant to antimicrobial drug treatment, a method of selecting a treatment of a patient suffering from an antibiotic resistant Salmonella infection, and a method of determining an antibiotic resistance profile for bacterial microorganisms of Salmonella species, as well as computer program products used in these methods. In an exemplary method, a sample 1 is used for molecular testing 2, and then a molecular fingerprint 3 is taken. The result is then compared to a reference library 4, and the result 5 is reported.

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RECOMBINANT VECTOR COMPRISING TRYPTOPHANYL-TRNA SYNTHETASE GENE AND USE THEREOF

NºPublicación: WO2019054699A1 21/03/2019

Solicitante:

THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIV [KR]

KR_101886415_B1

Resumen de: WO2019054699A1

The present invention relates to a recombinant vector comprising a pig-derived tryptophanyl-tRNA synthetase gene and a use thereof, wherein the recombinant vector of the present invention may be usefully used for production of a recombinant protein by using a tryptophanyl-tRNA synthetase protein as a fusion partner to increase the receptivity of a target protein in a host cell.

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种鸡伤寒沙门氏菌弱毒分离株及其应用

NºPublicación: CN109486714A 19/03/2019

Solicitante:

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Resumen de: CN109486714A

本发明涉及种鸡伤寒沙门氏菌弱毒分离株及其应用。所述分离株保藏于中国普通微生物菌种保藏管理中心(CGMCC),保藏地址为中国北京,保藏编号为CGMCC No.16049,保藏日期为2018.07.02,分类命名为鸡伤寒沙门氏菌。该菌株对不同年龄鸡均为弱毒,无致病性,可作为预防禽伤寒沙门氏菌感染和预防家禽(鸡)感染性疾病的菌株载体。本发明为评估沙门氏菌弱毒疫苗株的毒力及作为家禽(鸡)活疫苗的菌株载体的潜力提供了数据参考。

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A METHOD OF REDUCING EGG CONTAMINATION

NºPublicación: CN109496156A 19/03/2019

Solicitante:

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CA_3025410_A1

Resumen de: WO2017202804A1

The present invention relates to Salmonella mutant strains and their use as a vaccine for preventing Salmonella infection, in particular in eggs.

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ANTIBODIES TARGETING A GALACTAN-BASED O-ANTIGEN OF K. PNEUMONIAE

NºPublicación: RU2017132168A 18/03/2019

Solicitante:

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JP_2018508208_A

Resumen de: WO2016131503A1

The invention provides for an isolated antibody that specifically recognizes a galactan-III epitope of the lipopolysaccharide (LPS) O-antigen structure of Klebsiella pneumoniae, which epitope is incorporated in galactan-III repeating units, wherein the galactan-III repeating unit is a branched galactose homopolymer of Formula (I). The invention further provides for a pharmaceutical or diagnostic preparation comprising said antibody, and a method of producing said antibody.

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MICROFLUIDICS FOR ANALYTE DETECTION BASED ON THE LIGHT TO HEAT CONVERSION PROPERTIES OF METAL NANOPARTICLES

NºPublicación: CN109475861A 15/03/2019

Solicitante:

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US_2019118174_A1

Resumen de: WO2017167769A1

The present invention refers to the in vitro use of a microfluidic kit or device comprising a support or substrate, wherein said support or substrate comprises at least one channel in the substrate, the channel comprising an inlet, an outlet, and a flow-path connecting the inlet and outlet, wherein the inlet and outlet together define a midplane; and a portion of the flowpath travels transversely across the midplane, wherein the portion of the flowpath that travels transversely across the midplane includes a recognition site or sensing area for detecting a target analyte; for detecting an analyte as a result of the heat generated by metal nanoparticles when they are irradiated with an external light source.

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BIOMARKERS FOR PREDICTING RESPONSE TO CLOSTRIDIUM DIFFICILE

NºPublicación: WO2019048461A1 14/03/2019

Solicitante:

BIOSYS UK LTD [GB]

Resumen de: WO2019048461A1

The invention relates to methods for identifying/selecting cows for immunisation and to the use of markers for such methods. The methods involve interrogation of cells from a cow, and the use of markers in those cells to identify cows for immunisation. Cows are selected for immunisation by observing the change in expression of markers resulting from stimulating a cell obtained from a cow with C. difficile and/or a C. difficile specific antigen.

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SALMONELLA SIIE-DERIVED PEPTIDES FOR MANIPULATION OF LONG-LIVED PLASMA CELLS

NºPublicación: WO2019048540A1 14/03/2019

Solicitante:

DEUTSCHES RHEUMA FORSCHUNGSZENTRUM BERLIN [DE]
NATIONAL UNIV CORPORATION CHIBA UNIV [JP]

Resumen de: WO2019048540A1

The invention relates to an isolated polypeptide comprising or consisting of an amino acid sequence according to SEQ ID NO 1 (AS 136-154) (EEAEKAKEAAEKALNEAFE) or an amino acid sequence with a sequence identity of least 70 %, preferably of at least 80 %, more preferably of at least 90 % to SEQ ID NO 1, wherein the polypeptide is no longer than 200, preferably no longer than 170 amino acids. The invention relates to a nucleic acid encoding for said polypeptide, a gene therapy vector comprising said nucleic acid and genetically modified cells expressing said polypeptide. Furthermore, the invention relates to the medical use of said polypeptide, said nucleic acid, said gene therapy vector and/or said cell for the treatment of a disease associated with pathogenic long-lived plasma cells.

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Composition, Probiotic Formulation and Method to Reduce Bacterial Infection in Poultry

NºPublicación: US2019075821A1 14/03/2019

Solicitante:

NOVOZYMES AS [DK]
THE BOARD OF TRUSTEES OF THE UNIV ARKANSAS [US]
UNIV ARKANSAS [US]

WO_2017132201_A1

Resumen de: US2019075821A1

The present disclosure relates to compositions and probiotic formulations of bacterial isolates, and methods for selecting bacterial isolates capable of reducing levels of Salmonella and/or Campylobacter in poultry. Methods for reduction of Salmonella and/or Campylobacter in poultry are also part of the invention.

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YEAST VACCINE VECTOR INCLUDING IMMUNOSTIMULATORY AND ANTIGENIC POLYPEPTIDES AND METHODS OF USING THE SAME

NºPublicación: EP3452069A1 13/03/2019

Solicitante:

UNIV ARKANSAS [US]
TEXAS A & M UNIV SYS [US]

KR_20190015712_A

Resumen de: WO2017192671A1

Vaccine compositions including a yeast comprising an immunostimulatory polypeptide and optionally an antigenic polypeptide are provided herein. The immunostimulatory polypeptide and the antigenic polypeptide are expressed or displayed on the surface of the yeast vaccine composition. Methods of using the vaccine composition to vaccinate subjects are also provided.

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COMPOSITION COMPRISING BACTERIOPHAGES FOR REDUCING, ELIMINATING AND/OR PREVENTING SALMONELLA ENTERITIDIS, SALMONELLA TYPHIMURIUM AND SALMONELLA PARATYPHI B

NºPublicación: US2019070231A1 07/03/2019

Solicitante:

UNIV DE LOS ANDES [CO]

Resumen de: US2019070231A1

The present invention relates to a new cocktail of bacteriophages with specific lytic activity against Salmonella enteritidis, Salmonella typhimurium and Salmonella paratyphi B., for reducing, eliminating and/or preventing them in farm animals and animals from the poultry sector, such as poultry, hens and breeding hens, in addition to eggs. It may be administered as an additive in the feed, in water or by spray. Moreover, the cocktail may be used as a disinfectant in work areas of farms and abattoirs, and in processed foods, without affecting the organoleptic properties of the product.

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A NOVEL CONJUGATE FOR VACCINATION AGAINST TYPHOID COMPRISING CHEMICAL CONJUGATE OF VI POLYSACCHARIDE AND FLAGELLIN, A PROCESS FOR PRODUCING THE SAME AND A COMPOSITION COMPRISING THE CONJUGATE

NºPublicación: EP3448424A1 06/03/2019

Solicitante:

NAT INSTITUTE OF IMMUNOLOGY [IN]

US_2019134177_A1

Resumen de: WO2017187448A1

The present investigation relates to a conjugate comprising flagellin adjuvant covalently linked to Vi polysaccharide derived from S. typhi for vaccination against typhoid. Both flagellin adjuvant and Vi polysaccharide are from S. typhi which leads to the improved immunogenicity. The conjugate of the present invention may be used as single dose administration without the need of multiple immunizations. The present invention also discloses a nanoparticle composition comprising the conjugate of the present invention.

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ENGINEERING GUT COMMENSAL BACTERIA TO EXPRESS HETEROLOGOUS PROTEINS IN THEIR OUTER MEMBRANE VESICLES (OMVS) FOR DELIVERY TO THE GI-TRACT

NºPublicación: EP3449005A1 06/03/2019

Solicitante:

QUADRAM INST BIOSCIENCE [GB]
UEA ENTERPRISES LTD [GB]

US_2019099477_A1

Resumen de: WO2017187190A1

This invention relates to the delivery of heterologous peptides or proteins such as therapeutic peptides, therapeutic proteins or antigens to mucosal sites using vesicles derived from the outer membrane of commensal bacteria, recombinant bacteria capable of producing such vesicles, and methods for the production of such vesicles. The invention further relates to an inducible expression system for use in recombinant bacteria.

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ANTIMICROBIAL AGENTS AGAINST SALMONELLA BACTERIA

NºPublicación: EP3448992A1 06/03/2019

Solicitante:

LYSANDO AG [LI]

Resumen de: WO2017186942A1

The present invention relates to the field of antimicrobial agents active against Salmonella bacteria. In particular, the present invention relates to polypeptides comprising a first and a second amino acid sequence, wherein the first amino acid sequence is an endolysin, and wherein the second amino acid sequence is an antimicrobial peptide, cationic peptide, hydrophobic peptide, amphipathic peptide or sushi peptide, and wherein the polypeptide comprises at least one sequence selected from the group consisting of SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:4 and derivatives thereof. In addition, the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding host cells. Finally, the present invention relates to applications of the inventive polypeptides, nucleic acids, vectors, and/or host cells, in particular in the pharmaceutical field and in the field of food and feed.

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牛源肠炎沙门菌trxB基因缺失的应用

Nº publicación: CN109402036A 01/03/2019

Solicitante:

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Resumen de: CN109402036A

本发明公开了牛源肠炎沙门菌trxB基因缺失株的构建方法,以及牛源肠炎沙门菌trxB基因缺失能够降低牛源肠炎沙门菌的毒力,且牛源肠炎沙门菌trxB基因缺失能够应用于肠炎沙门菌疫苗。本发明利用Red同源重组方法构建牛源肠炎沙门菌trxB基因缺失株,并对其生物学特性和毒力进行研究,明确了trxB基因缺失引起牛源肠炎沙门菌毒力下降,为设计牛源肠炎沙门菌疫苗靶点提供参考,进而防治肠炎沙门菌感染,同时能够进步探索肠炎沙门菌TrxB蛋白的生理学功能。

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