SALMONELLA

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Resultados 71 resultados LastUpdate Última actualización 19/08/2019 [19:35:00] pdf PDF

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days

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DETECTION OF MICROORGANISMS IN FOOD SAMPLES AND FOOD PROCESSING FACILITIES

NºPublicación: US2019203267A1 04/07/2019

Solicitante:

CLEAR LABS INC [US]

US_2019204317_A1

Resumen de: US2019203267A1

Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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ANTIBODIES AGAINST MICROORGANISMS AND USES THEREOF

NºPublicación: US2019202896A1 04/07/2019

Solicitante:

NOVOBIND LIVESTOCK THERAPEUTICS INC [CA]

WO_2017199094_A1

Resumen de: US2019202896A1

Described herein are methods and antibodies useful for reducing, eliminating, or preventing infection with a bacterial population in domestic animals or humans. Also described herein are antigens useful for targeting by heavy chain antibodies and VHH fragments for reducing a bacterial population in domestic animals or humans.

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INORGANIC POLYATOMIC OXYANIONS FOR PROTECTING AGAINST ANTIGENIC DAMAGE DURING PATHOGEN INACTIVATION FOR VACCINE PRODUCTION

NºPublicación: US2019201520A1 04/07/2019

Solicitante:

NAJIT TECH INC [US]

JP_2019515047_A

Resumen de: US2019201520A1

Provided are methods for rapidly inactivating a pathogen, or for producing a vaccine composition containing an inactivated noninfectious pathogen having retained antigenicity and/or immunogenicity, comprising exposing the pathogen to a chemical inactivating agent (e.g., one or more chemical oxidizing, alkylating or crosslinking agents) in the presence of inorganic polyatomic oxyanions in an amount and for a time sufficient to render the pathogen noninfectious while enhancing retention of pathogen antigenicity and/or immunogenicity relative to that retained by contacting the pathogen with the chemical inactivating agent alone. The methods are broadly applicable to pathogens having RNA or DNA genomes (e.g., including viruses, bacteria, fungi, and parasites). Also provided are vaccine compositions (medicaments) containing a pathogen inactivated by exposure to a an inactivating agent in the presence of elevated concentrations of inorganic polyatomic oxyanions, and methods for eliciting an immune response in a subject by administering the vaccine compositions.

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AUTOMATED PRIMING AND LIBRARY LOADING DEVICE

NºPublicación: WO2019133756A1 04/07/2019

Solicitante:

CLEAR LABS INC [US]

AU_2018353924_A1

Resumen de: WO2019133756A1

Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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AUTOMATED PRIMING AND LIBRARY LOADING DEVICE

NºPublicación: US2019203287A1 04/07/2019

Solicitante:

CLEAR LABS INC [US]

Resumen de: US2019203287A1

Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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DETECTION OF MICROORGANISMS IN FOOD SAMPLES AND FOOD PROCESSING FACILITIES

NºPublicación: US2019204317A1 04/07/2019

Solicitante:

CLEAR LABS INC [US]

US_2019203267_A1

Resumen de: US2019204317A1

Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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MASS SPECTROMETRIC METHODS AND KITS TO IDENTIFY A MICROORGANISM

NºPublicación: EP3504552A1 03/07/2019

Solicitante:

THERMO FISHER SCIENTIFIC OY [FI]

US_2019212338_A1

Resumen de: WO2018037089A1

The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.

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A COMPANION DIAGNOSTIC METHOD FOR USE IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME WITH DIETARY INTERVENTIONS OR FAECAL MICROBIOTA TRANSPLANT

NºPublicación: BR112019007424A2 02/07/2019

Solicitante:

GENETIC ANALYSIS AS [NO]

CN_110114471_A

Resumen de: WO2018069538A1

The present invention provides a diagnostic method which may be used to determine the likelihood that a subject with Irritable Bowel Syndrome (IBS) will respond to treatment with an IBS intervention diet or faecal microbiota transplant (FMT). In particular, the method may be used to predict, or determine the likelihood of, a positive response of the subject with IBS to treatment with an IBS intervention diet or FMT, especially to determine the likelihood that the dietary intervention or FMT may have a positive (i.e. beneficial) effect on the subject's Gl tract, specifically the Gl tract microbiota, or other symptoms or complications of IBS (e.g. reducing severity thereof). The method of the present invention is based on analysing the abundance of certain bacteria in Gl tract samples, e.g. by nucleic acid analysis.

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A METHOD OF REDUCING EGG CONTAMINATION

NºPublicación: US2019192647A1 27/06/2019

Solicitante:

UNIV GENT [BE]

MX_2018014532_A

Resumen de: US2019192647A1

The present invention relates to Salmonella mutant strains and their use as a vaccine for preventing Salmonella infection, in particular in eggs.

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SALMONELLA VACCINES

NºPublicación: US2019192646A1 27/06/2019

Solicitante:

MODERNATX INC [US]

Resumen de: US2019192646A1

The disclosure relates to Salmonella ribonucleic acid vaccines as well as methods of using the vaccines and compositions comprising the vaccines.

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MASS SPECTROMETRIC METHODS AND KITS TO IDENTIFY A MICROORGANISM

NºPublicación: CN109937363A 25/06/2019

Solicitante:

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US_2019212338_A1

Resumen de: WO2018037089A1

The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.

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PROCESS FOR THE PRODUCTION OF A DNA VACCINE FOR CANCER IMMUNOTHERAPY

NºPublicación: US2019183996A1 20/06/2019

Solicitante:

VAXIMM AG [CH]

JP_2019521154_A

Resumen de: US2019183996A1

The present invention relates to a method for producing a DNA vaccine for cancer immunotherapy comprising at least the steps of (a) transforming an attenuated strain of Salmonella with at least one DNA molecule comprising at least one expression cassette encoding at least one antigen or at least one fragment thereof; (b) characterizing at least one transformed cell clone obtained in step (a); and (c) selecting at least one of the transformed cell clone(s) characterized in step (b) and further characterizing said at least one selected transformed cell clone. The present invention further relates to a DNA vaccine obtainable by the method according to the present invention.

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HEV VACCINE

NºPublicación: JP2019516745A 20/06/2019

Solicitante:

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US_2019151442_A1

Resumen de: WO2017202973A1

The present invention relates to a vaccine comprising Open Reading Frame 2 (ORF2) protein of Swine Hepatitis E virus (HEV) and a pharmaceutically acceptable carrier, for use in the protection of anti- HEV MDA-positive piglets against HEV fecal shedding.

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DESIGN OF PROTECTIVE ANTI-ZIKV VACCINE WITHOUT INDUCING CROSS-REACTIONS WITH DENGUE

NºPublicación: US2019185520A1 20/06/2019

Solicitante:

UNIV FLORIDA [US]

WO_2018018041_A1

Resumen de: US2019185520A1

The subject application provides a genetically modified recombinant facultative intracellular invasive bacterial pathogen (RFIIBP) or a recombinant attenuated Salmonella vaccine (RASV) strains encoding Zika virus (ZIKV) antigens. These strains exhibit high immunogenicity, complete safety, and attenuation, and are unable to persist or be shed in an infective or viable form. These RFIIBPs and RASVs also exhibit regulated delayed attenuation in vivo, regulated delayed in vivo synthesis of protective ZIKV antigens. Methods of inducing mucosal, systemic and cellular immunities in hosts are also provided and antibodies produced using the disclosed RFIIBPs and RASVs can comprise neutralizing antibodies against ZIKV that do not crossreact with Dengue virus (DENV).

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Methods for affecting salmonella infections

NºPublicación: AU2017381803A1 20/06/2019

Solicitante:

CSL BEHRING AG
CENTRE HOSPITALIER UNIV VAUDOIS

WO_2018115048_A1

Resumen de: AU2017381803A1

The invention relates to methods promoting the aggregation of Salmonella bacteria in the gut of subjects, thereby providing immune exclusion and limiting bacterial entry, therefore reducing mucosal and systemic infection.

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RAPID DETECTION METHOD FOR SALMONELLA IN DAIRY PRODUCT

NºPublicación: WO2019114374A1 20/06/2019

Solicitante:

NEW HOPE SHUANGXI DAIRY SUZHOU CO LTD [CN]

Resumen de: WO2019114374A1

A rapid detection method for Salmonella in a dairy product, mainly comprising the steps of pretreating the dairy product, extracting a DNA template in a sample to be tested, formulating a LAMP amplification reaction solution, and LAMP amplification and detection, where eosin and 2-hydroxy-3-naphthoic acid are added to the LAMP amplification reaction solution to allow a positive amplification product to express a specific fluorescent reaction, thus determining the presence of Salmonella. This detection method for Salmonella in the dairy product is simple, time-saving, highly accurate, and highly sensitive, requires merely 3-3.5 hours from the pretreatment of the dairy product to the acquisition of the final detection result, thus greatly increasing the freshness and shelf life of the dairy product being inspected; the positive coincidence rate of the result detected per the present method and C12Q of the result detected according to steps in GB 4789.4-2016 is 99.9% or more.

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PARTICLE MEASURING METHOD, SAMPLE PROCESSING METHOD, AND PARTICLE IMAGING APPARATUS

NºPublicación: CN109897888A 18/06/2019

Solicitante:

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US_2019178782_A1

Resumen de: EP3495508A1

A particle measuring method, a sample processing method, and a particle imaging apparatus capable of efficiently acquiring information effective in pathological diagnosis or the like are provided.The particle measuring method comprises a step (S13) of labeling and amplifying, within a particle, a target nucleic acid in the particle, a step (S14) of labeling a surface target polypeptide on the surface of the particle and/or target nucleic acid different from the first target nucleic acid, and a step (S2) of measuring the labeled target nucleic acid and the labeled target polypeptide and/or other labeled target nucleic acid.

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RAPID METHOD FOR DETECTIOIN OF SALMONELLA LIVE VACCINE STRAINS

NºPublicación: PH12018501995A1 17/06/2019

Solicitante:

IMICROQ S L [ES]

EA_201892078_A1

Resumen de: PH12018501995A1

The present specification discloses methods of detecting a Salmonella live vaccine bacteria of interest and components useful in carrying out these methods, including a first and second pre-enrichment media, and enrichment media and a detection solution.

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PRODUCTION AND USE OF PHOSPHOETHANOLAMINE CELLULOSE AND DERIVATIVES

NºPublicación: US2019177756A1 13/06/2019

Solicitante:

UNIV LELAND STANFORD JUNIOR [US]

WO_2018035411_A1

Resumen de: US2019177756A1

Phosphoethanolamine cellulose and methods of making and using it are disclosed. In particular, the invention relates to a method of producing a phosphoethanolamine cellulose biosynthetically using a BcsG phosphoethanolamine transferase for cellulose modification. Recombinant constructs encoding BcsG are described, including constructs encoding BcsG by itself or in combination with BcsE and BcsF, which increase the extent of cellulose modification and the amount of modified cellulose produced. Production of phosphoethanolamine cellulose in cell culture and derivatization of phosphoethanolamine cellulose are also described.

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COMPOSITION FOR USE IN THE PREVENTION OR TREATMENT OF SALMONELLOSIS

NºPublicación: WO2019112418A1 13/06/2019

Solicitante:

NUTRILEADS B V [NL]

Resumen de: WO2019112418A1

The invention relates to a composition for use in the prevention or treatment of Salmonellosis in animals, said use comprising administering the composition to the animal, wherein the composition contains at least 0.01 % by weight of dry matter of rhamnogalacturonan I (RG-I) polysaccharides having a molecular weight of more than 2 kDa and having a backbone consisting of galacturonic acid residues and rhamnose residues, said rhamnose residues being contained in alpha(1-→4)-galacturonic-alpha(1→2)-rhamnose residues, wherein the molar ratio of galacturonic acid residues to rhamnose residues in the RG-I polysaccharides is within the range of 50:1 to 1 : 1. The use of RG-I polysaccharides in the treatment or prevention of Salmonellosis provides an alternative for the widespread use of antibiotics. Furthermore, these RG-I polysaccharides may be used to prevent or treat Salmonellosis caused by Salmonella strains with resistance to antibiotics.

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VACCINE COMPOSITIONS

NºPublicación: WO2019110765A1 13/06/2019

Solicitante:

PROKARIUM LTD [GB]

EP_3495378_A1

Resumen de: WO2019110765A1

A genetically engineered non-natural bacterium comprising one or more of the following genetic modifications: (i). one or more heterologous genes encoding factors that prevent cell division, the expression of which are under the control of an inducible promoter activated when the bacterium is internalised into the intracellular vesicle of an animal cell; (ii). one or more endogenous factors that promote cell division, the expression of which are genetically modified to be repressed and/or prevented when the bacterium is internalised into the intracellular vesicle of an animal cell; and/or one or more endogenous factors that repress cell division, the expression of which are genetically modified to be under the control of an inducible promoter activated when the bacterium is internalised into the intracellular vesicle of an animal cell.

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VACCINE COMPOSITIONS II

NºPublicación: WO2019110819A1 13/06/2019

Solicitante:

PROKARIUM LTD [GB]

EP_3495469_A1

Resumen de: WO2019110819A1

The present invention provides a genetically engineered non-natural bacterium comprising inactivating mutations in one or more genes selected from pltA, pltB, cdtB and tts A, wherein the bacterium is derived from Salmonella spp, i n particular Salmonella enterica, such as S. enterica Typ hi, S. enterica Paratyphi A, S. enterica Paratyphi B or S. enterica Paratyphi C. The one or more inactivating mutations may comprise the partial or complete deletion of the one or more genes selected from pltA, pltB, cdtB and ttsA. The non-natural bacterium of the invention is provided for use in the treatment or prevention of a disease, such as an infectious disease or cancer. For example the bacterium may be for use in vaccination against a disease, such as typhoid or paratyphoid enteric fever. The bacterium may also be used as an anti-cancer therapy comprising suitable heterologous proteins.

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PARTICLE MEASURING METHOD, SAMPLE PROCESSING METHOD, AND PARTICLE IMAGING APPARATUS

NºPublicación: US2019178782A1 13/06/2019

Solicitante:

SYSMEX CORP [JP]

CN_109897888_A

Resumen de: US2019178782A1

A particle measuring method, a sample processing method, and a particle imaging apparatus capable of efficiently acquiring information effective in pathological diagnosis or the like are provided. The particle measuring method comprises a step (S13) of labeling and amplifying, within a particle, a target nucleic acid in the particle, a step (S14) of labeling a surface target polypeptide on the surface of the particle and/or target nucleic acid different from the first target nucleic acid, and a step (S2) of measuring the labeled target nucleic acid and the labeled target polypeptide and/or other labeled target nucleic acid.

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COMPOSITION FOR DELIVERY OF ACTIVE AGENTS TO AN ANIMAL

NºPublicación: US2019174748A1 13/06/2019

Solicitante:

ADVANCED BIONUTRITION CORP [US]

Resumen de: US2019174748A1

The present invention provides compositions for delivering an active agent to an animal, comprising an active agent, a first coating, a second coating and a third coating. The active agent is coated with the first coating, the first coating is coated with the second coating, and the second coating is coated with the third coating. The active agent is in contact with the first coating, not the second or third coating. The first coating separates the active agent from the second coating while the second coating separates the first and third coatings. The first, second and third coatings are different from each other. Also provided are methods for making and using the compositions.

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METHODS FOR PREVENTING OR TREATING INFECTIOUS DISEASES CAUSED BY EXTRACELLULAR MICROORGANISMS, INCLUDING ANTIMICROBIAL-RESISTANT STRAINS THEREOF, USING GALLIUM COMPOUNDS

Nº publicación: US2019175644A1 13/06/2019

Solicitante:

ICAHN SCHOOL MED MOUNT SINAI [US]
CAHN SCHOOL OF MEDICINE AT MOUNT SINAI [US]

Resumen de: US2019175644A1

The present invention relates to methods for preventing or treating infectious diseases caused by extracellular microorganisms, such as bacteria and fungi, by systemically administering to a patient a compound containing gallium. The extracellular microorganisms targeted by the present methods include methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus faecalis (VRE), E. coli O157:H7, fluoroquinolone-resistant Salmonella typhi, and the like. Furthermore, in the present methods, gallium compounds can be co-administered with one or more conventional antimicrobial agents to treat infectious diseases with reduced risks of creating multi-drug resistant pathogens. The methods of the present invention is also applicable to those microorganisms, such as ulcer-causing Helicobacter pylori, complete eradication of which so far has been difficult to achieve.

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