CORONAVIRUS: DIAGNÓSTICO Y TERAPIA EN HUMANOS

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Solicitudes publicadas en los últimos 365 días/Published applications in the last 365 days



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HUMAN BETACORONAVIRUS LINEAGE C AND IDENTIFICATION OF N-TERMINAL DIPEPTIDYL PEPTIDASE AS ITS VIRUS RECEPTOR

NºPublicación: EP3741846A2 25/11/2020

Solicitante:

UNIV ERASMUS MED CT ROTTERDAM [NL]
DR SOLIMAN ABDULKHADER FAKEEH HOSPITAL COMPANY [SA]

US_2015275183_A1

Resumen de: EP3741846A2

The invention provides an isolated essentially mammalian positive-sense single stranded RNA virus classifiable as belonging to the Order: Nidovirales; Family: Coronaviridae; Subfamily: Coronavirinae; Genus: Betacoronavirus; and non-Lineage A, non-Lineage B or non-Lineage D, human betacoronavirus. The invention also provides a human virus having a receptor binding domain (RBD) capable of binding to a dipeptidyl peptidase 4. The invention also provides diagnostic means and methods, prophylactic means and methods and therapeutic means and methods to be employed in the diagnosis, prevention and/or treatment of disease, in particular of respiratory disease, in particular of mammals, more in particular in humans.

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Methods of Treating Cytokine Storm Infections, Including COVID-19, By Inhibiting CCR5/CCL5 (RANTES) Interaction, and Compositions for Practicing the Same

NºPublicación: US2020362044A1 19/11/2020

Solicitante:

INCELLDX INC [US]

Resumen de: US2020362044A1

Methods of treating a subject suffering from COVID-19 are provided. Aspects of the methods including administering to the subject an effective amount of an inhibitor of CCR5/CCL5 interaction, such as a CCR5 antagonist. Also provided are methods of assessing severity of a disease involving hypercytokinemia, such as COVID-19, by determining the level of CCL5/RANTES in a subject, as well as compositions for use in such methods.

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LIVE IMAGING SYSTEM TO VISUALIZE THE RETRO-TRANSCRIBED VIRAL DNA GENOME

NºPublicación: WO2020229893A1 19/11/2020

Solicitante:

PASTEUR INSTITUT [FR]

Resumen de: WO2020229893A1

A recombinant lentiviral vector comprising a coding sequence for an OR protein fused to a coding sequence for a fluorescent protein or a subunit of a fluorescent protein, and a promoter active in human cells operatively linked to the coding sequences. A recombinant lentivirus comprising a recombinant genome comprising an RNA that generates an ANCH sequence upon retrotranscription. A recombinant eukaryotic cell comprising a genomically integrated DNA copy of the recombinant lentiviral vector. A method of observing lentiviral DNA in a eukaryotic cell, comprising: providing a recombinant eukaryotic cell that produces a fusion protein comprising an OR protein, fused to a fluorescent protein or a subunit of a fluorescent protein; infecting the recombinant eukaryotic cell with a recombinant lentivirus comprising a recombinant genome comprising an RNA that generates an ANCH sequence upon retrotranscription, under conditions sufficient for reverse transcription of the recombinant lentiviral genome comprising an ANCH sequence; allowing the OR protein to bind to the ANCH sequence; and detecting the fluorescent protein or subunit of the fluorescent protein to thereby observe the lentiviral DNA in the eukaryotic cell. This tool can be suitable also for in vivo applications (e.g. humanized mice) as well as for screening of new antiretroviral compounds. The HIV-1 ANCHOR system can be extended to the study of other viruses or for the screening of antiviral compounds, e.g. against SARS-CoV2.

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PEPTIDES HAVING PROTEASE ACTIVITY FOR USE IN THE TREATMENT OR PREVENTION OF CORONAVIRUS INFECTION

NºPublicación: US2020353060A1 12/11/2020

Solicitante:

ENZYMATICA AB [SE]

KR_20200107958_A

Resumen de: US2020353060A1

The present invention provides a polypeptide having protease activity for use in the treatment or prevention of coronavirus infection in a mammal. In particular, the invention relates to treatment or prevention of a coronavirus infection in a human, using trypsins.

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EARLY COVID PREDICTION: NEURO FUZZY MULTI-LAYERED DATA CLASSIFIER

NºPublicación: AU2020102448A4 12/11/2020

Solicitante:

HARI KRISHNA T DR [IN]
KALLAM SURESH DR [IN]
KUMAR MADAPURI RUDRA DR [IN]
PRASANTHI B MS [IN]
RAMANA KADIYALA DR [IN]
SENTHIL MAHESH P C DR [IN]
SURYA NARAYANA G DR [IN]

Resumen de: AU2020102448A4

EARLY COVID PREDICTION: NEURO FUZZY MULTI-LAYERED DATA CLASSIFIER Abstract Coronavirus disease (COVID-19) is a harmful disease caused from new SARS-CoV-2 virus. COVID-19 disease includes the symptoms such as cold, cough, fever and difficulty in breathing. COVID-19 has affected many countries and their spread in world has put humanity at risk. Due to increasing number of cases and their stress on administration as well as health professionals, different prediction techniques were introduced to predict the corona virus disease existence in patients. However, the accuracy was not improved and time consumption was not minimized during the disease prediction. In order to address these problems, Least Square Regressive Gaussian Neuro Fuzzy Multi-Layered Data Classification (LSRGNFM-LDC) Technique is introduced in this article. LSRGNFM-LDC Technique performs efficient COVID prediction with better accuracy and lesser time consumption through feature selection and classification. Deming Least Square Regressive Feature Selection process is carried out for selecting the most relevant features through identifying the line of best fit. After the feature selection process, the data classification is carried out using neuro-fuzzy classifier with help of fuzzy if-then rules for performing prediction process. Finally, the patient data is predicted as the higher risk patient data, medium risk patient data or higher risk patient data in more accurate manner with higher accuracy and lesser time

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A medicine for treating coronavirus-2 infection

NºPublicación: AU2020102463A4 12/11/2020

Solicitante:

DIAO BO [CN]
LIU YUEPING [CN]

Resumen de: AU2020102463A4

The invention discloses a medicine for treating coronavirus-2 infection. The invention finds that T cells in COVID-19 patients is reduced and depleted finally, indicating that cytokines such as IL-10, IL-6, TNF-a may directly mediate reduction of T cells. Therefore, ICU patients need new treatment measures, and may even high-risk patients with low T cells count require early preventive treatment.

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HMGB1 ANTAGONIST

NºPublicación: WO2020227603A1 12/11/2020

Solicitante:

THE FEINSTEIN INSTITUTES FOR MEDICAL RES [US]

US_2020353037_A1

Resumen de: WO2020227603A1

The present invention is related to HMGB1 antagonists, and in particular, HMGB1 tetramer peptidomimetics which have been stabilized with at least one azatide linkage, such as K883 such as K883 and to pharmaceutical compositions comprising HMGB1 antagonists such as K883. The present invention is also related to the use of HMGB 1 antagonists such as K883 to treat a human for e.g. an autoimmune or inflammatory disease or condition, for severe sepsis, for ALI, for influenza, for SARS-CoV-2, for a SARS virus, for neuropathic pain or for diabetic peripheral neuropathy.

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METHOD FOR IMPROVING OXYGENATING PULMONARY FUNCTION IN THE PATIENTS WITH A NEW CORONAVIRAL INFECTION (COVID-19) WITH RESPIRATORY FAILURE WHO ARE ON RESPIRATORY SUPPORT

NºPublicación: RU2735797C1 09/11/2020

Solicitante:

KHADARTSEV ALEKSANDR AGUBECHIROVICH [RU]

Resumen de: RU2735797C1

FIELD: medicine.SUBSTANCE: invention refers to medicine, namely to intensive care and resuscitation, and can be used for treating patients with a new coronavirus infection (COVID-19). Method involves intravenous introduction of a serotonin adipinate solution at rate of 10-30 mg/h to the patients with a new coronaviral infection COVID-19 with respiratory failure on respiratory support. Respiratory support is non-invasive lung ventilation, oxygen therapy; additionally, calcium nandroparin or enoxaparine are administered.EFFECT: using the invention enables improving the oxygenating function of the lungs by normalizing smooth muscle function of the microcirculatory bed of the lungs and other organs, and thereby increasing gas exchange.1 cl, 3 tbl, 3 ex

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TECHNOLOGY OF REMOTE MEDICAL REHABILITATION OF PATIENTS WITH CORONAVIRUS INFECTION

NºPublicación: RU2735722C1 06/11/2020

Solicitante:

FEDERALNOE GOSUDARSTVENNOE BIUDZHETNOE UCHREZHDENIE \u00ABNATSIONALNYI MEDITSINSKII ISSLEDOVATELSKII TSEN [RU]

Resumen de: RU2735722C1

FIELD: medicine.SUBSTANCE: invention relates to medicine, medical equipment and rehabilitation using computer technology, innovative electronic developments of distance learning and treatment systems, cloud systems and is based on use of a telemedicine platform for rehabilitation online sessions with patients suffering from or undergoing coronaviral infection in self-isolation mode, for complex improvement of the functions of their respiratory, cardiovascular, motor, digestive, and nervous systems. Remote rehabilitation is performed on a cloud telemedical platform - COVIDREHAB, using a device suitable for unobstructed Internet access and video communication in real time. First, patient leaves online application on platform portal for remote rehabilitation, filling a set of questionnaires, attending physician checks completed questionnaires: health assessment, mMRC (Modified Medical Research Council), SF-36, and determines indications and contra-indications for remote rehabilitation in accordance with information received from patient. If, in the process of filling out the questionnaires, the patient indicates a symptom that is dangerous or critical for life and health, patient immediately receives notification from attending physician on in-person seeking of medical care. According to results of patient filling questionnaires and analyzing available information on patient's condition, attending physician through portal of telemedicine platform opens the patient access to set

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TECHNOLOGY OF REHABILITATION-PREVENTIVE NUTRITIONAL SUPPORT IN CORONAVIRUS INFECTION

NºPublicación: RU2735723C1 06/11/2020

Solicitante:

FEDERALNOE GOSUDARSTVENNOE BYUDZHETNOE UCHREZHDENIE \u00ABNATSIONALNYJ MEDITSINSKIJ ISSLEDOVATELSKIJ TSEN [RU]

Resumen de: RU2735723C1

FIELD: medicine.SUBSTANCE: invention refers to medicine, and concerns a method for nutritional support in coronavirus infection involving administering a complex of agents aimed at intestinal microbiota recovery, immune system functions, metabolism, where in patients with mild or moderate disease, as well as after suffering severe COVID-19 infection, switched to enteral nutrition, said recovery agents are represented by: high-protein diet (HPD); oral administration of prebiotic preparations based on gel of fucus; patients receiving hepatoprotectors take with meals for restoring liver function; also for 1.5-2 months, a fish oil-based preparation containing polyunsaturated fatty acids (PUFA) of omega-3; vitamin-mineral complexes containing minerals of zinc, selenium and vitamins; course of 1.5-2 months is taking vitamin D3 preparation; Maxilac symbiotic is taken; then - Stimbiphide prebiotic; during entire 2-3-month course of recovery, taking Yessentuki No. 4 chloride-hydrocarbonate-sodium borate mineral water, inhalation through a nebuliser with the same heated mineral water is performed 4-6 times day for 10 min, and after each meal rinses are performed with it.EFFECT: invention provides nutritional support in coronavirus infection.1 cl, 5 ex

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INHIBITION OF IL-1 AND IL-6 INFLAMMATION

NºPublicación: WO2020223608A1 05/11/2020

Solicitante:

THIOLAB LLC [US]

Resumen de: WO2020223608A1

This invention provides methods of treatment for a variety of inflammation pathologies using thione-forming disulfides (TFDs). The treatments are particularly effective in the context of inflammations primarily due to excessive activity of innate immune system components, macrophage activity and inflammation arising from excessive production of IL-1. TFD inhibition of both IL-1 and IL-6 can reduce the detrimental effects of the cytokine storms known to increase morbidity and mortality caused by certain infections, such as COVID-19 viral pneumonia.

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SARS-CoV-2 Pharmaceutical Composition for prevention or treatment of diseases caused by SARS-CoV-2

NºPublicación: KR102174934B1 05/11/2020

Solicitante:

동화약품주식회사

KR_102174935_B1

Resumen de: KR102174934B1

본 발명은 쥐꼬리망초(Justicia procumbens) 유기용매 추출물을 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 저스티시딘-A (Justicidin-A)를 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 저스티시딘-B (Justicidin-B)를 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 또는 6' 하이드록시 저스티시딘-B (6' hydroxyl justicidin-B)를 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 및 이들의 COVID-19 질환 예방 또는 개선용 식품 조성물에 관한 것이다. 본 발명의 쥐꼬리망초 무수 에탄올 추출물, 저스티시딘-A 저스티시딘-B, 및 6' 하이드록시 저스티시딘-B는 SARS-CoV-2 바이러스를 효과적으로 억제함을 나타내므로, SARS-CoV-2 바이러스에 의해 야기되는 질환을 효과적으로 예방, 치료 또는 개선할 수 있다.

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SARS-CoV-2 Pharmaceutical Composition for prevention or treatment of diseases caused by SARS-CoV-2

NºPublicación: KR102174935B1 05/11/2020

Solicitante:

동화약품주식회사

KR_102174934_B1

Resumen de: KR102174935B1

본 발명은 쥐꼬리망초(Justicia procumbens) 유기용매 추출물을 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 저스티시딘-A (Justicidin-A)를 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 저스티시딘-B (Justicidin-B)를 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 또는 6' 하이드록시 저스티시딘-B (6' hydroxyl justicidin-B)를 유효성분으로 포함하는 COVID-19 질환의 예방 또는 치료용 약학적 조성물, 및 이들의 COVID-19 질환 예방 또는 개선용 식품 조성물에 관한 것이다. 본 발명의 쥐꼬리망초 무수 에탄올 추출물, 저스티시딘-A 저스티시딘-B, 및 6' 하이드록시 저스티시딘-B는 SARS-CoV-2 바이러스를 효과적으로 억제함을 나타내므로, SARS-CoV-2 바이러스에 의해 야기되는 질환을 효과적으로 예방, 치료 또는 개선할 수 있다.

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SPATIO-TEMPORAL MODELING TECHNIQUES FOR PREDICTING COVID-19 INFECTION RISK THROUGH WEARABLE

NºPublicación: AU2020102363A4 05/11/2020

Solicitante:

AGGARWAL VIBHA DR [IN]
BHARGAVA CHERRY DR [IN]
GUPTA SANDEEP DR [IN]
KALLAM SURESH DR [IN]
KRISHAN BAL DR [IN]
RANI USHA MRS [IN]
SHARMA PARDEEP KUMAR DR [IN]
SHIPRA [IN]
SINGLA SANDEEP KUMAR MR [IN]
SINGLA VIRINDER KUMAR MR [IN]

Resumen de: AU2020102363A4

SPATIO-TEMPORAL MODELING TECHNIQUES FOR PREDICTING COVID-19 INFECTION RISK THROUGH WEARABLE DEVICE DATA Significant general wellbeing occurrences, for example, COVID-19, ordinarily have attributes of being unexpected, dubious, and dangerous. On the off chance that an administration can successfully gather enormous information from different sources and utilize suitable explanatory strategies, it might rapidly react to accomplish ideal general wellbeing choices, subsequently improving adverse effects from a general wellbeing episode and all the more rapidly reestablishing ordinariness. Even though numerous reports and studies are analyzing how to utilize massive information for plague counteraction, there is as yet an absence of a robust audit and structure of the utilization of big data in the battle against significant general well being episodes, for example, COVID-19, which would be a useful reference for governments. This development gives away from on the attributes of COVID-19, as well as critical large information assets, enormous information for the representation of pandemic counteraction and control, close contact screening, online popular conclusion checking, infection have an examination, and pandemic gauge assessment. A system is given as a multidimensional reference to the successful utilization of enormous information examination innovation to forestall and control pandemics. The difficulties and proposals for applying considerable information for battling COVI

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AN ARTIFICIAL INTELLIGENCE BASED SYSTEM FOR COVID PREVENTION

NºPublicación: AU2020102382A4 05/11/2020

Solicitante:

BHASIN NARINDER KUMAR DR [IN]
FAKIH AWAB HABIB MR [IN]
GULATI KAMAL DR [IN]
JADHAV SHITAL SHIVNARAYAN MRS [IN]
KUZHALOLI S DR [IN]
KSHIRSAGAR PRAVIN R DR [IN]
PATIL SONAL PRAMOD MRS [IN]
PATIL SWATI ARUN MRS [IN]
RAHAMATHUNNISA U DR [IN]
RANJANA DR [IN]
SAHU JITENDRA KUMAR DR [IN]
SAHU MANABHANJAN DR [IN]
SINHA DIVYANSHU MR [IN]
SOLUNKE HIRALAL BHASKAR MR [IN]
SRIVASTAVA ALOK MR [IN]
VACHHANI HARSHITA MRS [IN]
VANMATHI C DR [IN]
VARALAKSHMI L M DR [IN]
KUMAR K VEERA DR [IN]

Resumen de: AU2020102382A4

The present invention relates to an artificial intelligence based system for COVID prevention. The proposed invention incorporates a definite number of subsystems each enabling checks and/or preventive actions against the most obvious symptoms of coronavirus. The invention has to be deployed at the entry point of the place of human assembly restricts the virus-infected people from entering the premise; and hence, mixing of the covid-infected population and the fit ones can be prevented to lower the further spread of coronavirus. The system includes methods for measuring the body-temperature and coughing of the entrant. It includes a method which detects if the entrant is not in possession of the protective face-mask. In case, any of the aforementioned tests disqualify the entrant, an alarming system comes into action intimating the local officials about the situation; otherwise, the entrant is allowed to enter the premise after sanitizing his hands. Following invention described in detail with the help of figure 1 of sheet 1 which shows schematic diagram of proposed invention. Figure IA

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MICROELECTRONIC SENSOR WITH BOLOMETRIC OR PYROELECTRIC DETECTOR FOR SENSING ELECTRICAL SIGNALS IN SUB-TERAHERTZ AND TERAHERTZ FREQUENCY RANGES

NºPublicación: WO2020222149A1 05/11/2020

Solicitante:

EPITRONIC HOLDINGS PTE LTD [SG]

Resumen de: WO2020222149A1

The present invention relates to an open-gate pseudo-conducting high-electron mobility transistor (PC-HEMT) combined with a bolometric or pyroelectric detector installed in an open gate area of the transistor, for amplifying signals in the frequency range between 30 GHz to 430 THz. The transistor of the present invention further comprises either an asymmetric dual grating gate created on top of a detector layer, or a separately-biased grating gate created on top and in the middle of the detector layer. The grating gate is capable of completely depleting the 2DEG or 2DHG conducting channel locally, while leaving the remaining area under the grating gate to be tuned for resonant plasmon absorption of sub-THz or THz radiation. A microelectronic sensor comprising the PC-HEMT of the present invention is suitable for chemical sensing and biomolecular diagnostics. Non-limiting examples of biological compounds to be tested are human viral pathogens, such as SARS-CoV-2.

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DETECTION OF SARS-COV-2 IN A PLURALITY OF BIOLOGICAL SAMPLES

NºPublicación: US2020347465A1 05/11/2020

Solicitante:

DRK BLUTSPENDEDIENST BADEN WUERTTEMBERG HESSEN GEMEINNUETZIGE GMBH [DE]
JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN [DE]

Resumen de: US2020347465A1

A method is for the detection of SARS-CoV-2 in a plurality of biological samples of living beings and a kit is for carrying out the method. The method includes providing at least one biological sample of a first living being and at least one biological sample of at least a second living being. The samples from the first and second living beings are suspected of containing SARS-CoV-2 and/or SARS-CoV-2 derived material. At least an aliquot of each of the biological samples are pooled to obtain a pool sample. The pool sample is tested for the presence of SARS-CoV-2 and/or SARS-CoV-2 derived material.

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MINIATURIZED DEVICE TO STERILIZE FROM COVID-19 AND OTHER VIRUSES

NºPublicación: US2020345873A1 05/11/2020

Solicitante:

NXGEN PARTNERS IP LLC [US]

Resumen de: US2020345873A1

A system for sterilizing viruses includes beam generation circuitry for generating a radiating wave having radiating energy therein at a predetermined frequency therein. A controller controls the radiating wave generation at the predetermined frequency. The predetermined frequency equals a resonance frequency of a particular virus. The predetermined frequency induces a mechanical resonance vibration at the resonance frequency of the particular virus within the particular virus for destroying a capsid of the particular virus. Radiating circuitry projects the radiating wave on a predetermined location to destroy the particular virus at the predetermined location.

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METHOD AND SYSTEM FOR CONTROLLED HYPERTHERMIA

NºPublicación: US2020345920A1 05/11/2020

Solicitante:

VERTREES ROGER [US]
WINETZ JAN [US]

Resumen de: US2020345920A1

Methods and for treatment of cancer and other diseases including complications from late stage viral infections by inducing hyperthermia in a patient relying on withdrawing blood from the patient and returning the withdrawn blood to the patient to establish an extracorporeal flow circuit. Blood is heated by passing through the extracorporeal circuit at a controlled rate until a target body core temperature in is achieved. Usually, the blood will be subjected to a continuously re-circulating dialysis to balance electrolytes. Additionally, the blood will be subjected to a continuously recirculating regeneration through a carbon sorbent column where toxins and contaminants are removed. The blood temperature is maintained at the target blood temperature for a treatment period, and the blood is cooled after the treatment period has been completed. The method can also be effective in treating rheumatoid arthritis, scleroderma, hepatitis, sepsis, the Epstein-Barr virus, and patients with life threatening complications from other viruses, including the COVID-19 virus. A method for removing viruses from the blood supply in an external circuit is also presented.

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A METHOD FOR DETERMINING THE EFFICACY OF A SARS-COV-2 VACCINE

NºPublicación: EP3734286A1 04/11/2020

Solicitante:

EUROIMMUN MEDIZINISCHE LABORDIAGNOSTIKA AG [DE]

Resumen de: EP3734286A1

The present invention relates to method for determining whether a subject produces antibodies as a result of administration of a vaccine for distinguishing whether a subject produces antibodies as a result of administration of a vaccine or as a result of a previous corona virus infection, comprising the step detecting in a sample comprising antibodies from said subject the absence or presence of an antibody to SEQ ID NO1 and the absence or presence of an antibody to SEQ DI NO2.

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Lateral flow immunoassay test reader and method of use

NºPublicación: US10823746B1 03/11/2020

Solicitante:

BUSA WILLIAM [US]
COELHO PHILLIP H [US]
GETCHEL PAUL [US]
THERMOGENESIS HOLDINGS INC [US]

Resumen de: US10823746B1

A reader for a lateral flow test device includes a tray or drawer, extendable from the reader, which receives the test device. The tray includes a calibration test pattern affixed or printed thereon placed proximate to the test device and in alignment with the axis of the test device. As the tray is closed and the test device is inserted to the reader, the calibration test pattern is first read by an optics unit including a photodiode. The resulting photodiode output provides a calibration curve S that the reader then uses to correct for any non-linear response of the reader's optical or electronic systems, thus insuring that every reader will yield the same readout for a given test cartridge, despite reader-to-reader variations or reader degradation with time. One use of the reader is for detection of SARS-CoV-2 infection.

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Molecules that bind to SARS-CoV-2

NºPublicación: US10822379B1 03/11/2020

Solicitante:

UNIV OF PITTSBURGH\u2014OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION [US]

Resumen de: US10822379B1

This document provides methods and materials involved in binding a binder (e.g., an antibody, antigen binding fragment, and/or antibody domain) to a SARS-CoV-2 antigen. For example, binders (e.g., antibodies, antigen binding fragments, and antibody domains) that bind to a SARS-CoV-2 polypeptide and methods and materials for using one or more such binding molecules to treat a mammal (e.g., a human) having COVID-19 (or a viral infection caused by SARS-CoV-2) are provided.

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-19 44-Diaminodiphenyl Sulfone as an Inflammasome Competitor of Oral Vaccine or Therapeutics for SARS-CoV-2 or COVID-19

NºPublicación: KR20200124185A 02/11/2020

Solicitante:

이종훈

Resumen de: KR20200124185A

이 연구의 목적은 예방제로서 inflammasome 경쟁자의 사용을 조사하는 것이 었습니다. 코로나 바이러스는 다른 종의 수용체에 결합하는 S 단백질의 적응성으로 인해 동물 감염 가능성이 있으며, 특히 SARS-CoV에 의해 입증되었습니다. SARS-CoV-2와 TLR의 결합은 카스파제 -1에 의해 절단되는 pro-IL-1β의 방출을 일으켜 폐염증, 발열 및 섬유증의 매개인 인플라마 좀의 형성 및 활성화를 유발합니다. NLRP3 인플 라마 좀은 알츠하이머병 (AD), 프리온 병, 제 2 형 당뇨병 및 수많은 전염병을 포함한 다양한 인간 질병과 관련이 있습니다. 이 연구는 알츠하이머 병으로도 진단된 한센병 환자의 치료에서 4,4'-diaminodiphenyl sulfone (DDS)의 사용을 조사함으로써 inflammasome의 활성화와 관련된 다양한 메커니즘을 보여줍니다. 유전적 다형성으로 인해 TLR은 바이러스를 포함한 다양한 미생물 리간드에 대한 면역 반응을 변경할 수 있습니다. 특히 TLR2Arg677Trp는 한국인 한센병 나형 환자에게만 존재하는 것으로 보고되었습니다. 이전에, TLR2의 세포 내 도메인의 돌연변이는 LL에 대한 감수성을 결정하는 역할을 입증했지만, LL은 DDS와 리팜피신 및 클로파지민의 조합을 사용하여 성공적으로 치료되었습니다. 테스트된 세 가지 항생제 중 DDS는 경미한인지장애 (MCI), 파�

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ELECTROCHEMICAL APPROACH FOR COVID-19 DETECTION

NºPublicación: US2020340945A1 29/10/2020

Solicitante:

ABDOLAHAD MOHAMMAD [IR]
SADAT MIRIPOUR ZOHREH [IR]
SANATI KOLOUKHI HASSAN [IR]
SHOJAEIAN ZANJANI FATEMEH ZAHRA [IR]
NANO HESGARSAZAN SALAMAT ARIA [IR]\n

Resumen de: US2020340945A1

A method for diagnosing COVID-19 infection of a person. The method includes acquiring a sputum sample of a person, measuring a level of ROS in the sputum sample, and detecting a COVID-19 infection status of the person based on the measured level of ROS. Measuring the level of ROS in the sputum sample includes recording a cyclic voltammetry (CV) pattern from the sputum sample and measuring a current peak of the recorded CV pattern. Detecting the COVID-19 infection status of the person includes detecting COVID-19 infection of the person responsive to the measured current peak being in a first range of more than 230 μA and detecting COVID-19 non-infection of the person responsive to the measured current peak being in a second range of less than 190 μA.

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A SYSTEM FOR DETECTION OF CORONA VIRUS IN HUMAN BODY USING ARTIFICIAL INTELLIGENCE

Nº publicación: AU2020102228A4 29/10/2020

Solicitante:

AGRAWAL PANKAJ DR [IN]
B VENKAIAHPPALASWAMY MR [IN]
BHASIN NARINDER KUMAR DR [IN]
BHAT NAGARAJ MR [IN]
GULATI KAMAL DR [IN]
HERUR SANTOSH MR [IN]
KALPANA V DR [IN]
KSHIRSAGAR PRAVIN R DR [IN]
M MAHENDRA B MR [IN]
MADHUSUDAN [IN]
SHARMA ARVIND K DR [IN]
SIDHU RAJWINDER SINGH MR [IN]
SONTH MAHESH V DR [IN]
TAKYI KATE MR [IN]
TEWARI RANJANA DR [IN]
UPRETI KAMAL DR [IN]
YASEEN SYED MUFASSIR MR [IN]

Resumen de: AU2020102228A4

Abstract The present invention relates to a system for detection of corona virus in human body using artificial intelligence. The proposed can detect likelihood of the Covid-19, measure oxygen saturation and temperature of the patient. Invented system comprises a testing stand which having stethoscopes connected to a microphone to listen and record the respiratory sounds of the patient, a pulse oximeter to measure the oxygen saturation level of the patient, an IR temperature sensor to measure the temperature of the patient and a computer which comprises of a machine learning software to combine and analyse all readings to produce the final result. Following invention described in detail with the help of figure 1A of sheet 1 shows covid-19 diagnostic system with a patient, figure 1B of sheet 1 shows expanded view of covid-19 diagnostic system. (103) (104) -- (10s) (100) (106) (1i2)re1) Figure 1A (103) (10)100) (105) (104) (1108) '107) (102) (101) Figure 1B

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