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Resultados 94 resultados LastUpdate Última actualización 16/12/2017 [17:02:00] pdf PDF




Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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WELL-DEFINED DEGRADABLE POLY(PROPYLENE FUMARATE) POLYMERS AND SCALABLE METHODS FOR THE SYNTHESIS THEREOF

NºPublicación: US2017355815A1 14/12/2017

Solicitante:
BECKER MATTHEW [US]
DEAN HOWARD [US]
LUO YUANYUAN [US]
UNIV AKRON [US]
THE OHIO STATE UNIV [US]

Resumen de: US2017355815A1

The present invention provides a low molecular mass PPF polymer (and related methods) that is suitable for 3D printing and other polymer device fabrication modalities and can be made inexpensively in commercially reasonable quantities. These novel low molecular mass PPF polymers have a low molecular mass distribution (m) and a wide variety of potential uses, particularly as a component in resins for 3D printing of medical devices. The ability to produce low m PPF creates a new opportunity for reliable GMP production of PPF. It provides low cost synthesis and scalability of synthesis, blending of well-defined mass and viscosity PPF, and reduced reliance on solvents or heat to (a) achieve mixing of 3D printable resins or (b) and flowability during 3D printing. These PPF polymers are non-toxic, degradable, and resorbable and can be used in tissue scaffolds and medical devices that are implanted within a living organism.



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MULTI-LAYER SKIN SUBSTITUTE PRODUCTS AND METHODS OF MAKING AND USING THE SAME

NºPublicación: US2017354763A1 14/12/2017

Solicitante:
UNIV WAKE FOREST HEALTH SCIENCES [US]

Resumen de: US2017354763A1

Provided are live, artificial, skin substitute products and methods of making and using the same, such as for wound treatment and compound testing, including compound testing for efficacy, toxicity, penetration, irritation and/or metabolism testing of drug candidates or compositions such as cosmetics. Described herein is an artificial mammalian skin substitute product, comprising: (a) optionally, but in some embodiments preferably, a first (“hypodermis-like”) layer comprising live mammalian adipocytes (e.g., induced pre-adipocytes) in a first hydrogel carrier; (b) a second (“dermis-like”) layer contacting or directly contacting the first layer and comprising live mammalian fibroblast cells and' live mammalian follicle dermal papilla cells in combination in a second hydrogel carrier; (c) a third (“epidermis-like”) layer contacting or directly contacting the second layer (i.e., on the opposite side thereof as the first layer, so that the second layer is sandwiched between the first and third layers when the first layer is present), the third layer comprising live mammalian keratinocytes and live mammalian melanocytes in combination in a third hydrogel carrier.



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OMNIDIRECTIONAL DEPLOYABLE MULTICHANNEL NEURAL ELECTRODE SYSTEM

NºPublicación: EP3254726A1 13/12/2017

Solicitante:
NEURONEXUS TECH INC [US]

Resumen de: EP3254726A1

A neural probe system having a single guide tube that is inserted into neural tissue and from which a number of neural probes can be deployed is described. Each probe is deployable into tissue along a desired trajectory. This is done by supporting the electrode array on a spring tape-type carrier that maintains axial stiffness once the neural probe has deployed out a channel in the guide tube. That way, a target neural tissue is bounded by an increased number of neural probes while minimizing trauma to surrounding body tissue.



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种单喷头实现多材料层级复合3DP的装置

NºPublicación: CN206733600U 12/12/2017

Resumen de: CN206733600U

本实用新型涉及种三维打印技术(3DP),具体涉及使用单喷头实现多材料层级复合的3DP的装置。本实用新型是在不改变原有的三维打印技术设备平台基础上,通过设计配置级、二级物料筒,并经打印喷头的二级联动活塞装置,在不改变打印设备原有运动模式和控制软件的前提下,精确实现不多物料的连续共混挤出打印。本实用新型提供的多材料复合打印喷头,可充分复合多种打印材料,不同材料间混合充分,复合效果好,打印结构为层级包裹连续复合,具有较好的设备兼容性和可实施性,在生物医学领域具有广阔的应用前景。



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自动输送注料装置及3d打印牙模自动输送注料体机

NºPublicación: CN206718299U 08/12/2017

Resumen de: CN206718299U

本申请公开了自动输送注料装置,包括支架,所述支架上设有牙模放置工位及能对所述牙模放置工位上的牙模进行注料的注料装置,所述注料装置下方设有能对注料后的牙模进行固化的固化装置,所述支架上设有能将牙模输送至所述牙模放置工位上、或将牙模从所述牙模放置工位上取出的取放输送装置。其技术方案的要点是能使牙模加工过程中的注料、固化及放置等工序自动化进行,生产效率提高且降低人力成本。



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种无异味的环保印刷设备

NºPublicación: CN206715624U 08/12/2017

Resumen de: CN206715624U

本实用新型公开了种无异味的环保印刷设备,包括激光打印机,所述激光打印机的前端面设有进纸口以及出纸口,所述出纸口的下方位置设有除异味托盘,除异味托盘采用胶粘的形式固定在激光打印机的外壁上;除异味托盘内设有空腔,除异味托盘的上表面均匀的开设有进气孔,本实用新型在抽气风机的作用下产生抽气效果,此时放在除异味托盘的纸张所散发出的异味被抽入空腔内,然后经过抽气管进入空气过滤器内,此时经过空气净化滤芯的过滤除去异味,然后经过香薰盒的增香,最终从抽气风机的排气口排出,此时排出的空气具有定的香气,而且异味也被处理,从而不仅整体使用时没有异味,而且也更加环保。



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种人工关节股骨柄

NºPublicación: CN206714856U 08/12/2017

Resumen de: CN206714856U

本实用新型提供种人工关节股骨柄,在人工关节股骨柄本体上分布有孔或槽,在上述孔或槽内分布有柱突、球突或其他立体形状。不仅有助于植入物与骨组织之间形成制锁作用,能够为新骨的长入提供理想的空间结构,有利于改善骨组织细胞的附着、增生能力,达到良好的骨结合,增强了人工关节股骨柄与自体组织的融合性,有利于人工关节股骨柄在人体中长期有效地发挥作用;而且力学性能优异,机械强度高,能够很好降低应力遮挡,保持有效力学支撑。



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可调节角度上肢支具

NºPublicación: CN206714867U 08/12/2017

Resumen de: CN206714867U

本实用新型公开了种可调节角度上肢支具是由前支具、后支具、连接支具构成的厚度为0.3cm的弧形支撑架,前支具、后支具和连接支具分体设置且均由ABS材料或PLA材料通过3D打印成型,前支具与拇指对应的位置独立于与拇指之外的其他手指对应的位置,前支具与拇指之外的其他手指对应的位置为体式结构,前支具设有第连接孔,后支具设有第二连接孔,连接支具搭接在前支具和后支具的表面,且连接支具上设有第三连接孔和第四连接孔。本实用新型的可调节角度上肢支具重量轻,透气,不发臭,贴合度、舒适性好,病人易接受,方便进行康复训练,疗效好,安装时可避免对神经造成二次伤害,角度可调节,有助于恢复手神经损伤。



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GRAFT SCAFFOLD FOR CARTILAGE REPAIR AND PROCESS FOR MAKING SAME

NºPublicación: US2017348458A1 07/12/2017

Solicitante:
ETH ZUERICH [CH]

Resumen de: US2017348458A1

The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.



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MICRONEEDLE-ARRAY MANUFACTURING APPARATUS, MICRONEEDLE-ARRAY MANUFACTURING METHOD, AND PRODUCT HAVING THE MICRONEEDLE ARRAY

NºPublicación: US2017348880A1 07/12/2017

Solicitante:
NISSHA PRINTING [JP]
BIOSERENTACH CO LTD [JP]

Resumen de: US2017348880A1

A product having a microneedle array is provided wherein the composition distribution has been adjusted with good accuracy. A droplet-delivery apparatus of a microneedle-array manufacturing apparatus is configured capable of delivering, to each recessed part, droplets of a raw-material liquid in a prescribed amount that is less than the capacity of the recessed part. An aligning apparatus can align the relative position of the droplet-delivery apparatus and a mold such that the droplets from the droplet-delivery apparatus are caused to land in each of the recessed parts. The droplet-delivery apparatus delivers a plurality of the droplets to each of the recessed parts; and the aligning apparatus aligns the relative position of the droplet-delivery apparatus and the mold such that a second droplet lands in each of the recessed parts on the center part side of a first droplet.



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AIRWAY STENT AND TISSUE-ENGINEERED AIRWAY USING THE AIRWAY STENT, AND APPLICATION THEREOF

NºPublicación: WO2017206483A1 07/12/2017

Solicitante:
SHANGHAI CHILDREN'S MEDICAL CENTER AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE [CN]

Resumen de: WO2017206483A1

An airway stent and a tissue-engineered airway using the airway stent, and application thereof. The airway stent comprises a plurality of support rings (2) arranged at intervals. A supporting element (1) with a hollow mesh structure is provided between adjacent support rings (2). The airway stent provides excellent support, facilitates formation of cartilage of relatively better quality within two weeks, and can be directly used in transplanting.



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3D-PRINTED MYOELECTRIC HAND PROSTHESIS WITH IMPROVED THUMB MOVEMENT

NºPublicación: WO2017208100A1 07/12/2017

Solicitante:
ROBLEDO RAMIREZ JORGE ALBERTO [CO]

Resumen de: WO2017208100A1

The present invention relates to a 3D-printed myoelectric hand prosthesis with improved thumb movement, which comprises a plurality of mechanisms that provide independent movement to each finger and allow same to be fitted to any size of prosthesis, maintaining the strength and speed of the movements. Advantageously, the prosthesis of the present invention also allows the opposition of the thumb to the other fingers and the subterminolateral (key grip) opposition of the thumb, thereby providing a functionality closer to that of a human hand.



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PREPARATION AND APPLICATIONS OF RGD CONJUGATED POLYSACCHARIDE BIOINKS WITH OR WITHOUT FIBRIN FOR 3D BIOPRINTING OF HUMAN SKIN WITH NOVEL PRINTING HEAD FOR USE AS MODEL FOR TESTING COSMETICS AND FOR TRANSPLANTATION

NºPublicación: WO2017210663A1 07/12/2017

Solicitante:
GATENHOLM PAUL [US]

Resumen de: WO2017210663A1

The present invention relates to use of hydrogel based on RGD-conjugated alginate with and without addition of nanocellulose and/or fibrin as a novel bioink for 3D Bioprinting of human skin, particularly dermis. RGD-conjugated alginate provides adhesion sites for the human fibroblasts which result in cell adhesion and stretching which contribute to upregulation of genes producing Collagen I. In this invention, RGD-conjugated alginate is used as one of the components of the bioink for 3D bioprinting. Another innovation described herewith is use of coaxial needle when 3D bioprinting with alginate and RGD-modified alginate bioinks. A coaxial needle makes it possible to crosslink the bioink upon 3D bioprinting operation and thus achieve high printing fidelity which is required for high cell viability, proliferation and production of extracellular matrix. In this invention, the novel RGD-modified alginate bioink together with human fibroblasts is 3D bioprinted and the resulting construct shows high cell viability, high cell proliferation, high degree of stretching of fibroblasts and high productivity of Collagen I. The cell bioink construct biofabricated with this invention is ideal for testing cosmetics and active ingredients of skin care products particularly those used for skin regeneration. It is also ideal to be used as skin grafts for skin repair for patients with damaged or burned skin.



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INDIVIDUELLE BIOMATERIALSCHALE ZUR REKONSTRUKTION VON KNOCHENDEFEKTEN

NºPublicación: DE102017005036A1 07/12/2017

Solicitante:
DRAENERT FLORIAN [DE]

Resumen de: DE102017005036A1

Die Erfindung betrifft eine Vorrichtung zur Abdeckung und/oder Rekonstruktion einer Knochendefektstelle, die einen mit einem partikulärem Material unterfüllbaren Hohlraum zwischen Defektoberfläche und der dem Knochendefekt zugewandten Oberfläche der Vorrichtung aufweist, welcher einen Aufsatz bildet umfassend • einen einen Rahmen bildenden 3-dimensionalen Festkörper, und • eine darauf befestigte Membran, welche beide jeweils aus demselben oder unterschiedlichen Biomaterialien bestehen und eine dem Knochendefekt abgewandte Oberfläche und eine dem Knochendefekt zugewandte Oberfläche aufweisen, wobei die Abmessungen und 3-dimensionale Geometrie des Rahmens durch die Oberflächendaten des Knochendefektes, die mit Hilfe eines Schichtbildgebungsverfahrens gewonnen und mittels CAD-CAM-Technik weiterverarbeitet wurden, definiert sind. Ein weiterer Gegenstand der Erfindung ist ein Verfahren, ein angepasster Rahmen und ein System zur Herstellung der erfindungsgemäßen Vorrichtung.



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CUSTOMIZED SURGICAL GUIDES, METHODS FOR MANUFACTURING AND USES THEREOF

NºPublicación: EP3251619A2 06/12/2017

Solicitante:
MAT N V [BE]

Resumen de: EP3251619A2

A combination of a bone implant and a customized surgical guide for surgical instruments for placement on the bone implant with a unique fit, wherein said customized surgical guide comprises: - one or more customized guiding elements for the surgical instruments; - surfaces or parts thereof which ensure the unique fit with the implant; - surfaces or parts thereof which, upon placement, contact the bone and are supported by the bone and which specifically mate with areas of the bone.



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旋转支承结构、生物打印平台及其旋转杆结构的拆装方法

NºPublicación: CN107432777A 05/12/2017

Resumen de: CN107432777A

本发明公开了种生物打印平台的旋转支承结构和生物打印平台。旋转支承结构包括旋转轴结构和旋转杆结构,旋转杆结构与旋转轴结构具有组装状态和分解状态,在组装状态,旋转杆结构与旋转轴结构连接且旋转杆结构能够在旋转轴结构的带动下围绕旋转轴结构的中心轴线转动,在分解状态,旋转杆结构与旋转轴结构分离,其中,旋转杆结构与旋转轴结构配置为能够通过改变旋转杆结构与旋转轴结构在中心轴线的径向方向的距离实现旋转杆结构与旋转轴结构在组装状态和分解状态之间的切换。本发明可以提高旋转杆的拆装效率。



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用于制备生物构建体的方法和试剂盒

NºPublicación: CN107432955A 05/12/2017

Resumen de: CN107432955A

本发明涉及种用于制备生物构建体的试剂盒及其用途,所述试剂盒包含彼此分离的第试剂和第二试剂,其中,所述第试剂含有第组分,所述第二试剂含有第二组分,并且当所述第组分与第二组分接触时,能够产生粘连效果,实现粘合作用。此外,本发明还涉及种用于构建生物结构或组织的方法,其包括使用本发明的试剂盒。



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种拇指功能康复的外骨骼机器人

NºPublicación: CN107432816A 05/12/2017

Resumen de: CN107432816A

种拇指功能康复的外骨骼机器人,它涉及种外骨骼机器人。本发明解决现有的康复机械手未能充分模拟手指关节的自然运动,存在康复治疗的效果不尽人意以及不具备感知功能的问题。其中指间关节单元和掌指关节单元均采用平面导杆机构来驱动拇指的指间关节和掌指关节作屈曲或伸展运动;拇指腕骨关节单元通过掌背调整机构直接与拇指的腕骨关节对心实现腕骨关节的内收或外展运动;所述传动驱动机构采用直流电机作为动力源,绕线轮模块通过鲍登线将直流电机输出的力矩传递到指间关节单元、掌指关节单元和腕骨关节单元。本发明的拇指功能康复的外骨骼机器人适用于拇指功能康复。



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IMMOBILISATION ELEMENT AND ADDITIVE MANUFACTURING METHOD FOR MAKING SAME

NºPublicación: CN107438512A 05/12/2017

Resumen de: WO2016108154A1

This invention relates to a method for manufacturing an individualized immobilization element for the non-invasive immobilization and/or mobilization of at least a segment of a body part of a patient in a predetermined position relative to a reference and/or in a pre- certain configuration. The method comprises the steps of (i) providing a data set that comprises a three-dimensional image of an outer contour of at least a part of the segment of the body part to be immobilized and/or mobilized and (ii) the manufacture of at least a part of the immobilization element by rapid manufacturing of a shape on the basis of said data set using a polymeric material containing a thermoplastic polymer having a melting point less than or equal to 100°C, wherein the polymer material contains a nucleating agent for enhancing the of the crystallization of the thermoplastic polymer.



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种3D打印医疗颈部护套

NºPublicación: CN107411867A 01/12/2017

Resumen de: CN107411867A

本发明公开种3D打印医疗颈部护套,包括上护套和下护套;所述的上护套的宽度大于下护套的宽度,且所述的上护套和下护套均设置为半圆形结构;且所述的上护套的两侧端面内部均设置有卡槽,而所述的下护套的两侧端部则卡入到卡槽中固定从而构成整体为圆形结构的护套。本发明中的内部的气孔也使得上护套具备定的挤压变形能力,以及配合外部设置的按摩凸起,当病人坐立的倚靠的时候,外部按摩凸起和内部的气孔可以很好的受力;整体装置可大大提升病人颈部护理时的舒适度。



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儿童髋关节脱位手术用3D打印导航模板及其制作方法

NºPublicación: CN107411799A 01/12/2017

Resumen de: CN107411799A

本发明公开种儿童髋关节脱位手术用3D打印导航模板,包括覆盖髋骨外侧上部的上端和覆盖髋骨外侧下部的下端,在上端和下端的连接部位开有楔形槽孔,上端设置有可拆卸的切骨端盖,切骨端盖上设置有克氏针插入孔。本发明还公开种儿童髋关节脱位手术用3D打印导航模板的制作方法,本发明的导航模板的楔形槽孔和切骨端盖的设计为手术中切骨和锯断髂骨时进行精确定位,节省手术时间,增加手术精确度。导航模板根据每个患儿的不同的病情利用3D打印技术进行个性化的定制,完全适用每个婴幼儿患者。



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种3D打印的生物组合种牙植体设备

NºPublicación: CN107411833A 01/12/2017

Resumen de: CN107411833A

本发明公开了种3D打印的生物组合种牙植体设备,所述种牙植体设备完全贴合人体牙齿牙龈,所述种牙植体设备在缺牙部位设置有钻孔套帽,所述钻孔套帽上设置钻孔平台,在钻孔平台中心设有钻孔导向孔,在钻孔导向孔内设置有刚套,在所述牙植体设备上设置有透气孔,所述种牙植体设备采用3D打印技术打印制作而成。本发明的3D打印的生物组合种牙植体设备结构简单,设计合理,使用方便,生产成本低。通过按照不同病人的实际情况,制作不同数量和不同直径的钻孔导向孔,医生在手术过程中使用本设备可以根据不同的人的不同情况使用3D打印技术,这样使得医生手术中的每次使用钻头都能够按照预先的设计进行,使手术更加精确、科学。



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种复合细胞的预血管化大块生物骨支架构建方法

NºPublicación: CN107412851A 01/12/2017

Resumen de: CN107412851A

本发明公开了种复合细胞的预血管化大块生物骨支架构建方法,用于生物制造领域,采用复合生物3D打印、电流体动力学直写、减材制造和细胞组装技术在大块生物骨支架内部构建功能性预制血管化网络来促进大块骨缺损的修复。此方法的关键在于采用可在体内讲解的生物材料海藻酸钠作为牺牲材料,并在其中加载内皮细胞,通过内皮细胞自身的迁移粘附到预制血管网络表面,与此同时,海藻酸钠降解形成预制血管网络;此外,骨支架材料中的人骨髓间充质干细胞分化成成骨细胞,并与内皮细胞的相互促进作用下合成分泌骨基质,并矿化,提高骨组织修复的效率,解决了大块骨组织修复的功能性问题,对临床医学上解决大块骨组织修复问题具有重要意义。



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PATIENT-ADAPTED AND IMPROVED ORTHOPEDIC IMPLANTS, DESIGNS AND RELATED TOOLS

NºPublicación: CN107411852A 01/12/2017

Resumen de: WO2010151564A1

Methods and devices are disclosed relating improved articular models, implant components, and related guide tools and procedures. In addition, methods and devices are disclosed relating articular models, implant components, and/or related guide tools and procedures that include one or more features derived from patient-data, for example, images of the patient's joint. The data can be used to create a model for analyzing a patient's joint and to devise and evaluate a course of corrective action. The data also can be used to create patient-adapted implant components and related tools and procedures.



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管腔组织构建体及其制备方法、制备装置

Nº publicación: CN107411844A 01/12/2017

Resumen de: CN107411844A

本发明涉及种管腔组织构建体及其制备方法、制备装置,其中管腔组织构建体的制备方法包括:提供用于制备管腔组织构建体的内壁(5)和外壁(10),其中,所述内壁(5)为包含生物活性物质的生物构建体,所述外壁(10)为管状;将所述外壁(10)与所述内壁(5)通过套装方式固定连接在起。本发明单独提供内壁和外壁,并且外壁均管状结构,内壁为包含生物活性物质的生物构建体,可以通过套装的方式将内壁与外壁固定连接在起,从而形成管腔组织构建体,这种组装方法步骤简单,组装效率高,适用于批量生产。


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