SALMONELLA

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Resultados 67 resultados LastUpdate Última actualización 20/01/2022 [12:52:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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MULTI-FUNCTIONALIZED noMV CONJUGATES

NºPublicación: US2022008529A1 13/01/2022

Solicitante:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

WO_2019030271_A1

Resumen de: US2022008529A1

The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.

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SYSTEMS AND METHODS FOR DETECTING INFECTIOUS DISEASES

NºPublicación: JP2022002529A 11/01/2022

Solicitante:

ラブラドールダイアグノスティクスエルエルシー

BR_112016004994_A2

Resumen de: US2015072338A1

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.

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SELECTIVE SALMONELLA OR E. COLI CULTIVATION METHOD, COMPOSITIONS AND USES

NºPublicación: JP2022502087A 11/01/2022

Solicitante:

ソラスサイエンティフィックソリューションズリミティド

US_2022002663_A1

Resumen de: WO2020058707A1

The present disclosure provides rapid, convenient and sensitive means to detect low abundance target Gram negative bacteria such as Salmonella contamination from a range of samples, including food samples and environmental samples, through a single-step culture method and downstream sensitive detection.

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SYNTHETIC BINDING AGENTS FOR LIMITING PERMEATION THROUGH MUCUS

NºPublicación: JP2022502488A 11/01/2022

Solicitante:

ザユニバーシティオブノースカロライナアットチャペルヒルミューコミューン,リミテッドライアビリティカンパニー

US_2021347885_A1

Resumen de: WO2020061560A1

Synthetic binding agents for reducing the fraction of targets that can permeate through mucus and/or freely divide, and methods of reducing mucosal permeation and/or free division of a target using these synthetic binding agents.

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METHODS OF TREATMENT OF INFECTIONS USING BACTERIA

NºPublicación: JP2022502439A 11/01/2022

Solicitante:

デコイバイオシステムズインコーポレイテッドDECOYBIOSYSTEMS,INC.

EA_202190546_A1

Resumen de: US2020101119A1

The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non-viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines.

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BIOSENSOR FOR DETECTION OF SALMONELLA TYPHIMURIUM AND ITS APPLICATION

NºPublicación: AU2020205292A1 06/01/2022

Solicitante:

UNIV QINGDAO AGRICULTURAL

CN_111638330_A

Resumen de: AU2020205292A1

The present disclosure provides a biosensor for the detection of Salmonella typhimurium, belonging to the technical field of harmful microorganism detection. The biosensor is composed of a carbon quantum dot (Td-CD) modified by the aptamer of Salmonella typhimurium and a magnetic bead (Td-MB) modified by the aptamer of Salmonella typhimurium. Among them, the aptamer of Salmonella typhimurium is assembled with other nucleic acids to form a DNA tetrahedral structure through sequence design, and then used to modify carbon quantum dots and magnetic beads, respectively. The method of detecting Salmonella typhimurium by the biosensor of the present invention is simple to operate, short in time, and does not require complex pretreatment of the tested sample, with low detection cost. 2250 y 46.69x - 41.396 R2= 0.9987 0 1 2 3 4 5 6 7 Bacterial Concentration(log CFU-mL 1 ) Figure 2 40 Staphylococcus aureus 30 Listeria monocytogenes Escherichia coli E Salmonella typhimurium Figure 3

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LIVE SELF-DESTRUCTING BACTERIAL ADJUVANTS TO ENHANCE INDUCTION OF IMMUNITY

NºPublicación: US2022001008A1 06/01/2022

Solicitante:

UNIV FLORIDA [US]

WO_2020096994_A1

Resumen de: US2022001008A1

Disclosed herein are unique adjuvant compositions comprising an attenuated derivative of a bacterial pathogen that undergoes lysis in vivo. In exemplary embodiments, the bacterial pathogen is a Salmonella spp. Also disclosed are methods for enhancing an immune response using the adjuvants disclosed herein.

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Inert Carrier Salmonella and Potential Use Thereof

NºPublicación: US2022003763A1 06/01/2022

Solicitante:

UNIV YANGZHOU [CN]

WO_2020233148_A1

Resumen de: US2022003763A1

The present invention relates to an inert carrier Salmonella and potential use thereof, which is expected to be developed into a new inert carrier bacteria, and can be applied to the development of an indirect agglutination test method for simple and rapid detection of antigens or infected antibodies. The inert carrier Salmonella has been deposited in CGMCC in Beijing on Mar. 18, 2019 with the accession number of CGMCC No. 17340, and is classified as Salmonella sp. with a strain code of S9. The Salmonella has no visible agglutination reaction with various chicken sera derived from different genetic backgrounds, i.e., it has no non-specific agglutination reaction with chicken sera derived from broad range of genetic backgrounds.

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METHOD FOR ANALYZING MICROORGANISM

NºPublicación: US2022003764A1 06/01/2022

Solicitante:

SHIMADZU CORP [JP]

JP_2021173612_A

Resumen de: US2022003764A1

[OBJECT] To enable accurate identification of a specific serotype of Salmonella bacteria in a method for analyzing a microorganism using a MALDI-MS.[MEANS FOR SOLVING PROBLEM] The present invention is a method for analyzing a microorganism including an identification step for determining which of Abony and Pakistan which are two serotypes of Salmonella bacteria is contained in a sample which contains either Abony or Pakistan, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Minnesota. Infantis and Brandenburg which are three serotypes of Salmonella bacteria is contained in a sample which contains Minnesota. Infantis or Brandenburg, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample, or a method for analyzing a microorganism including an identification step for determining which of Schwarzengrund and Montevideo which are two serotypes of Salmonella bacteria is contained in a sample which contains either Schwarzengrund or Montevideo, based on the presence or absence of a peak (or peaks) at a predetermined mass-to-charge ratio (or ratios) in a mass spectrum obtained by a mass spectrometric analysis of the sample.

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METHOD FOR ANALYZING MICROORGANISM

NºPublicación: US2022003778A1 06/01/2022

Solicitante:

SHIMADZU CORP [JP]

JP_2021173611_A

Resumen de: US2022003778A1

A method for analyzing a microorganism according to the present invention includes: a step of reading, from a mass spectrum obtained by a mass spectrometric analysis of a sample containing a microorganism, a mass-to-charge ratio or ratios m/z of a peak or peaks originating from 1-10 kinds of proteins selected from the group, consisting of 10 kinds of proteins of gns, YaiA, YibT, PPI, L25, L21, S8, L17, L15 and S7 as well as any combination of the 10 kinds of proteins; and an identification step configured to determine, based on the read mass-to-charge ratio or ratios, m/z, of the peak or peaks, whether or not the microorganism contained in the sample contains at least one of the following six serotypes of Salmonella bacteria: Abaetetuba, Anatum, Newport, Poona, Tallahassee and Vellore.

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Mitrecin A Polypeptide with Antimicrobial Activity

NºPublicación: US2022000989A1 06/01/2022

Solicitante:

MITRE CORP [US]

US_2020353058_A1

Resumen de: US2022000989A1

The present invention provides a Mitrecin A polypeptide useful in prevention and treatment of one or more bacteria. Also provided is a method to kill or prevent growth of one or more bacteria comprising contacting the one or more bacteria with a Mitrecin A polypeptide. The target bacteria can be selected from the group consisting of a Gram-positive bacterium, a Gram-negative bacterium, or both. In one embodiment, the present invention is drawn to a polynucleotide encoding a Mitrecin A polypeptide, a vector comprising the polynucleotide, a host cell comprising the polynucleotide, or a composition comprising the Mitrecin A polypeptide, the polynucleotide, the vector, or the host cell.

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SELECTIVE SALMONELLA OR E. COLI CULTIVATION METHOD, COMPOSITIONS AND USES

NºPublicación: US2022002663A1 06/01/2022

Solicitante:

SOLUS SCIENT SOLUTIONS LTD [GB]

JP_2022502087_A

Resumen de: US2022002663A1

The present disclosure provides rapid, convenient and sensitive means to detect low abundance target Gram negative bacteria such as Salmonella contamination from a range of samples, including food samples and environmental samples, through a single-step culture method and downstream sensitive detection.

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TREATMENT OF BENIGN NERVOUS SYSTEM TUMORS USING ATTENUATED SALMONELLA TYPHIMURIUM

NºPublicación: EP3930745A1 05/01/2022

Solicitante:

MASSACHUSETTS GEN HOSPITAL [US]

CN_113766927_A

Resumen de: WO2020176764A1

Compositions and methods for the treatment of benign nervous system tumors including schwannomas using attenuated Salmonella typhimurium and optionally one or more checkpoint inhibitors.

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NOVEL PROTEIN TRANSLOCATION DOMAIN

NºPublicación: EP3932937A1 05/01/2022

Solicitante:

UNIV HAMBURG EPPENDORF [DE]

NANOPORE BIOSENSORS FOR DETECTION OF PROTEINS AND NUCLEIC ACIDS

NºPublicación: US2021405039A1 30/12/2021

Solicitante:

UNIV LEUVEN KATH [BE]

US_2020072824_A1

Resumen de: US2021405039A1

Described herein are nanopore biosensors based on a modified cytolysin protein. The nanopore biosensors accommodate macromolecules including proteins and nucleic acids, and may additionally comprise ligands with selective binding properties.

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Diagnosing Sepsis or Bacteremia by Detecting Peptidoglycan Associated Lipoprotein (PAL) in Urine

NºPublicación: US2021405048A1 30/12/2021

Solicitante:

MICHEL LEA [US]
HELLMAN JUDITH [US]
ROCHESTER INSTITUTE TECH [US]

WO_2020097499_A1

Resumen de: US2021405048A1

A method, device and kit for detecting sepsis or bacteremia in a patient includes detecting peptidoglycan associated lipoprotein (Pal) from Gram-negative bacteria in the urine of the patient is disclosed.

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MULTIVALENT GLYCOCONJUGATES IMMUNOGENIC COMPOSITIONS

NºPublicación: US2021401960A1 30/12/2021

Solicitante:

BHARAT BIOTECH INT LTD [IN]

CN_113271967_A

Resumen de: US2021401960A1

Provided are multivalent conjugate compositions against Salmonella diseases. A combined vaccine composition of glycol-conjugates in tetravalent, trivalent and bivalent combinations are disclosed.

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Salmonella strain for treating cancer and use thereof

NºPublicación: KR20210156804A 27/12/2021

Solicitante:

전남대학교산학협력단

WO_2021256599_A1

Resumen de: WO2021256599A1

The present invention relates to a Salmonella strain that selectively acts on cancer for the treatment of cancer, and a composition for preventing or treating cancer comprising same. Specifically, the Salmonella strain according to the present invention has a tumor-suppressing effect, but the viability thereof is significantly low in normal organs, and thus can have a significant anticancer effect compared to the conventional invention.

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COMPOSITIONS AND METHODS FOR PREVENTING AND TREATING VIRUS INFECTION

NºPublicación: US2021393768A1 23/12/2021

Solicitante:

UNIV VIRGINIA PATENT FOUNDATION [US]

WO_2020046982_PA

Resumen de: US2021393768A1

Disclosed herein are bacteria-based HIV MPER vaccine candidates, as well as bacteria-based candidates for other viruses and for bacteria. The HIV vaccine candidates express MPER-derived antigens on their surfaces using Gram autotransporters. The surface-expressed MPER antigens bind several different MPER-directed anti-HIV Broadly Neutralizing Monoclonal Antibodies. When the bacteria expressing the MPER-derived antigens on their surfaces are used to immunize mice they elicit the production of sera and vaginal wash material that bind the bacteria expressing the MPER antigens. At least one of the bacteria expressing MPER-derived antigens on their surfaces elicits the production of sera with anti-HIV neutralizing activity. Killed whole cell and live Salmonella expressing the MPER derived antigens on their surfaces constitute new approaches to HIV vaccine develop that is plausible and that could ultimately yield an inexpensive, globally appropriate candidate vaccine that could be rapidly produced and deployed largely using currently available technology.

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NOVEL DOSAGE REGIMEN TIACUMICIN COMPOUND

NºPublicación: JP2021193088A 23/12/2021

Solicitante:

アステラスファーマユーロープリミテッド

Resumen de: WO2017005358A1

The present inventors provides one or more of a tiacumicin compound, a stereo-isomer thereof, a polymorph thereof or a pharmaceutically acceptable solvate thereof for use in the oral treatment of Clostridium difficile infections (CDI) or Clostridium difficile-associated disease (CDAD) in a patient according to a dosage regimen comprising: (1) administering to the patient in an initial course of treatment 200 mg of the tiacumicin compound twice a day; (2) monitoring the efficacy of the initial course of treatment in the patient by means of monitoring changes of one or more indicators of CDI or CDAD; (3) assessing whether there is a positive change of the one or the more of the indicators; and (4) switching to an intermittent course of treatment by administering to the patient 200 mg of the tiacumicin compound every other day if the one or the more of the indicators of CDI or CDAD are positively changed. Further the invention provides the use of the tiacumicin compound to reduce recurrence in a patient suffering from CDI or CDAD.

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SALMONELLA STRAIN FOR TREATING CANCER AND USE THEREOF

NºPublicación: WO2021256599A1 23/12/2021

Solicitante:

UNIV NAT CHONNAM IND FOUND [KR]

KR_102327091_B1

Resumen de: WO2021256599A1

The present invention relates to a Salmonella strain that selectively acts on cancer for the treatment of cancer, and a composition for preventing or treating cancer comprising same. Specifically, the Salmonella strain according to the present invention has a tumor-suppressing effect, but the viability thereof is significantly low in normal organs, and thus can have a significant anticancer effect compared to the conventional invention.

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COMPOSITIONS FOR IMPROVING VACCINE SAFETY AND EFFICACY AND METHODS OF USE THEREOF

NºPublicación: US2021393696A1 23/12/2021

Solicitante:

UNIV KANSAS STATE [US]

WO_2020097226_A1

Resumen de: US2021393696A1

The present disclosure provides methods and compositions for reducing the incidence, severity, and/or duration of at least one sign of respiratory infection. The methods include the steps of administering a composition comprising gastrointestinal microbiota and an immunogenic composition to an animal in need thereof.

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SHIGELLA-TETRAVALENT (SHIGELLA4V) BIOCONJUGATE

NºPublicación: WO2021255684A1 23/12/2021

Solicitante:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

Resumen de: WO2021255684A1

A composition comprising Shigella-Tetravalent (4-valent Shigella) bioconjugates. That encompasses the Shigella O-polysaccharide antigens of serotypes Shigella flexneri 2a, 3a, 6 and Shigella sonnei covalently linked to the protein carrier.

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AUTOTRANSPORTER SYSTEM

NºPublicación: WO2021255480A1 23/12/2021

Solicitante:

PROKARIUM LTD [GB]

Resumen de: WO2021255480A1

The present invention provides for a modified autotransporter and the use of genetically engineered microorganisms comprising said modified autotransporters in the treatment of infectious and neoplastic disease. The present invention therefore also relates to vaccine and immunotherapeutic compositions comprising said genetically engineered microorganism.

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VACCINE AGAINST KLEBSIELLA PNEUMONIAE

Nº publicación: US2021386845A1 16/12/2021

Solicitante:

IDORSIA PHARMACEUTICALS LTD [CH]

JP_2021504438_A

Resumen de: US2021386845A1

The present invention relates to a synthetic oligosaccharide of general formula (I): T*-[(—Ux+4—Ux+3—Ux+2—Ux+1—Ux)m—(Vx+2—Vx+1—Vx)1-m-T-O-L-E that is related to Klebsiella pneumoniae serotype O3, O3b and/or O5 lipopolysaccharide and conjugate thereof. Said synthetic oligosaccharide, said conjugate and pharmaceutical composition containing said synthetic oligosaccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Klebsiella pneumoniae. Furthermore, the synthetic oligosaccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Klebsiella pneumoniae serotype O3, O3b and/or O5 bacteria.

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