BIOMARCADORES PARA DIAGNÓSTICO DE DEMENCIA

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Resultados 50 resultados LastUpdate Última actualización 27/01/2023 [14:21:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 60 días / Applications published in the last 60 days



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NEURODEGENERATIVE DISEASE MARKER AND APPLICATION THEREOF

NºPublicación: WO2023284035A1 19/01/2023

Solicitante:

SHENZHEN INST ADV TECH [CN]

CN_115612728_PA

Resumen de: WO2023284035A1

A neurodegenerative disease marker and an application thereof. The neurodegenerative disease marker comprises a cystatin C coding gene NM_009976.4. It is found for the first time that the expression of cystatin C coding gene in Alzheimer disease brain tissue (cortex, hippocampus, and synapse) is down-regulated, but the level of cystatin C protein in the peripheral serum of Alzheimer disease is increased, and therefore, early diagnosis of Alzheimer disease can be performed by measuring the indicators.

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BLOOD-BASED ASSAY FOR DIAGNOSING AND TREATING BASED ON SITE-SPECIFIC TAU PHOSPHORYLATION

NºPublicación: US2023017557A1 19/01/2023

Solicitante:

WASHINGTON UNIVERSITY ST LOUIS [US]

JP_2022547209_A

Resumen de: US2023017557A1

The present disclosure provides methods to quantify tau phosphorylation at specific amino acid residues, using blood samples, to predict time to onset of mild cognitive impairment due to Alzheimer's disease, stage Alzheimer's disease, guide treatment decisions, select subjects for clinical trials, and evaluate the clinical efficacy of certain therapeutic interventions.

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CROSS-LINKED PRODUCT OF AMYLOID-B PROTEIN (AB) AS POTENTIAL SUBSTITUTE FOR AMYLOSPHEROIDS (ASPD) AND ANALYSIS OF ASPD

NºPublicación: US2023021187A1 19/01/2023

Solicitante:

FOUNDATION FOR BIOMEDICAL RES AND INNOVATION AT KOBE [JP]

CN_114729932_A

Resumen de: US2023021187A1

A substance that can be a substitute for amylospheroids (ASPD) and a method for analyzing ASPD are provided. Viewed from one aspect, the present disclosure relates to a substance in which amyloid-β protein (Aβ) is cross-linked with a cross-linking agent that has a spacer arm length of between 4 Å and 50 Å inclusive or a cross-linking agent that has, as a spacer arm, not less than 1 and not more than 13 groups that are an oxyethylene group(s) (—CH2CH2O—) and/or an oxypropylene group(s) (—CH2CH2CH3O—). Viewed from another aspect, the present disclosure relates to a method for analyzing ASPD using the substance as a reference material.

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BIOMARKERS FOR ALZHEIMER'S DISEASE

NºPublicación: WO2023285462A1 19/01/2023

Solicitante:

FONDAZIONE ST ITALIANO TECNOLOGIA [IT]
FOND SANTA LUCIA [IT]

Resumen de: WO2023285462A1

Disclosed are N-acylphosphatidylethanolamine (NAPE) molecules as biomarkers for Alzheimer's disease (AD), the use thereof in a method for the diagnosis or prognosis of AD, and a kit for implementation of the method.

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ANTIBODIES TO a-SYNUCLEIN AND USES THEREOF

NºPublicación: AU2022252753A1 19/01/2023

Solicitante:

ABL BIO INC [KR]

MX_2020004674_A

Resumen de: AU2022252753A1

The present invention relates to an anti-alpha-synuclein antibody preferentially recognizing alpha-synuclein aggregates and a use of detection, diagnosis, and/or treatment or prevention of various diseases caused by accumulation of alpha-synuclein aggregates, or their related symptom diseases by using the anti-alpha-synuclein antibody.

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DIAGNOSTIC METHODS USING PGC-1Α EXPRESSION

NºPublicación: EP4118435A1 18/01/2023

Solicitante:

BIORCHESTRA CO LTD [KR]

KR_20220154772_PA

Resumen de: WO2021181364A1

The present disclosure relates to the use of PGC-1α expression to identify a subject that is conducive to treatment with a miR-485 inhibitor. In some aspects, the subject suffers from a disease or disorder associated with reduced PGC-1α expression. In some aspects, the PGC-1α expression is measured in the serum of the subject.

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DIAGNOSTIC METHODS USING SIRT1 EXPRESSION

NºPublicación: EP4118436A1 18/01/2023

Solicitante:

BIORCHESTRA CO LTD [KR]

KR_20220155585_PA

Resumen de: WO2021181365A1

The present disclosure relates to the use of SIRT1 expression to identify a subject that is conducive to treatment with a miR-485 inhibitor. In some aspects, the subject suffers from a disease or disorder associated with reduced SIRT1 expression. In some aspects, the SIRT1 expression is measured in the serum of the subject.

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DEVICES, KITS, AND METHODS FOR DETERMINING INCREASED SUSCEPTIBILITY TO AND TREATMENT AND PREVENTION OF PERIODONTITIS, ALZHEIMER'S DISEASE, AND OTHER CONDITIONS

NºPublicación: WO2023283021A1 12/01/2023

Solicitante:

LEVINE MARTIN [US]

Resumen de: WO2023283021A1

Diagnostic microarray devices, kits, and methods of treating or reducing the occurrence of various conditions or diseases are disclosed, wherein the conditions or diseases include (but are not limited to) periodontal disease, Alzheimer's disease, cardiovascular disease, arthritis, and adverse pregnancy outcomes. The devices, kits, and methods utilize an analysis of single nucleotide polymorphisms (SNPs) from various interleukins.

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BIOMARKERS FOR ALZHEIMER'S DISEASE TREATMENT

NºPublicación: WO2023283650A1 12/01/2023

Solicitante:

EISAI R&D MAN CO LTD [JP]
SWANSON CHAD [US]

Resumen de: WO2023283650A1

Disclosed herein are method of diagnosing, selecting, monitoring, and treating subjects with Alzheimer's disease (AD) or suspected of having AD or another disorder associated with amyloid accumulation in the brain.

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METHOD FOR THE DETECTION OF APOLIPOPROTEIN E4

NºPublicación: JP2023002599A 10/01/2023

Solicitante:

シュピーンゴテックゲゼルシャフトミットベシュレンクテルハフツング

US_2021223242_A1

Resumen de: EP3309550A1

The present invention provides a method for the detection of Apolipoprotein E isotype 4 (ApoE4) or fragments thereof in a blood sample of a subject, whereby said method comprises the steps of contacting said sample with a solid phase, contacting said sample with at least one binder binding specifically to ApoE4 or a fragment thereof, thereby forming an ApoE4binder-complex, and detecting the ApoE4-binder-complex.

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MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS

NºPublicación: US2023003721A1 05/01/2023

Solicitante:

DAVIS RONALD L [US]
LIU ZE [US]
VARKUTI BOGLARKA H [HU]
KEPIRO MIKLOS [HU]
MACMULLEN COURTNEY M [US]
THE UNIV OF FLORIDA RESEARCH FOUNDATION INC [US]

WO_2021113127_A2

Resumen de: US2023003721A1

Described herein is a multiplexed and high content screening assay using primary neurons for identifying small molecule modulators of neuronal mitochondrial mitostasis (MnMs). Also described is a high throughput screening assay using primary neurons for identifying small molecules that increase mitochondrial function, identified by measuring the electrochemical potential across the inner mitochondrial membrane and ATP generation. Most MnMs that increased mitochondrial content, length and/or health also increased mitochondrial function without altering neurite outgrowth. Some MnMs protect mitochondria in primary neurons from Aβ(1-42) toxicity, glutamate toxicity, increased oxidative stress and the toxic cellular environment associated with Alzheimer's disease. Some MnMs target mitochondria directly. An MnM also increases the synaptic activity of hippocampal neurons and is potent in vivo, increasing the respiration rate of brain mitochondria after administering the compound to mice. The MnMs were demonstrated to protect the mitochondrial population in neurons in an in vivo model of Alzheimer's Disease. Also described is a method for treating a patient suffering from a disorder characterized by dysfunction of neuronal mitostasis, comprising administering to the patient a therapeutically effective amount of a compound (MnM), or a pharmaceutically acceptable salt thereof.

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SCREENING METHOD OF THERAPEUTIC AGENT FOR BRAIN DISEASES

NºPublicación: WO2023277459A1 05/01/2023

Solicitante:

HUSCION CO LTD [KR]

Resumen de: WO2023277459A1

The present invention relates to a screening method of a therapeutic agent for brain diseases. Specifically, the screening method according to the present invention can be useful for screening a therapeutic agent for brain diseases. The screening method is based on the fact that Rg3, which is known to have a therapeutic effect for Alzheimer's disease, promotes NF-κB signaling mechanisms while promoting M2 polarization and suppressing M1 polarization, suppresses Aβ accumulation by increasing SRA protein expression, and suppresses water-soluble APPα processing in neural cells through water-soluble APPα generation and the suppression of Aβ42 generation by increasing ADAM10 protein expression in microglia or neuroblastoma.

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MARKER OF ALZHEIMER'S DISEASE AND USE THEREOF

NºPublicación: WO2023272576A1 05/01/2023

Solicitante:

SHENZHEN INST OF ADV TECH CAS [CN]

Resumen de: WO2023272576A1

Provided in the present application is a marker of Alzheimer's disease, which marker comprises monocyte chemoattractant protein-1 (MCP 1). Further provided in the present application are a method for detecting the marker of Alzheimer's disease, a kit for detecting Alzheimer's disease, and the use of the marker, the detection method and the kit in the screening of a drug for treating Alzheimer's disease.

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METHODS FOR QUANTIFICATION OF AMYLOID BETA PEPTIDES IN PLASMA BY MASS SPECTROMETRY

NºPublicación: KR20230002465A 05/01/2023

Solicitante:

아라클론바이오테크에스엘

CN_115427815_A

Resumen de: WO2021219917A1

The present invention relates to a method for preparing a plasma sample comprising amyloid beta peptides for analysis by mass spectrometry, comprising the steps of: a) placing said plasma sample in contact with a denaturing agent, b) performing a first solid phase extraction step on the solution obtained in step a) to recover a first eluate, c) performing a second solid phase extraction step on said first eluate obtained in step b) to recover a second eluate, and d) drying said second eluate obtained in step c) and processing it for analysis by mass spectrometry, wherein the solution obtained in step d) comprises intact amyloid beta peptides Aß40 and Aß42.

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CSF-BASED PROGNOSTIC BIOMARKERS IN ALZHEIMER'S DISEASE AND METHODS OF USE THEREOF

NºPublicación: US2023003744A1 05/01/2023

Solicitante:

UNIV RUTGERS [US]
UNIV EMORY [US]

Resumen de: US2023003744A1

Embodiments of the disclosure are directed to biomarkers, or a panel of biomarkers, that determine progression of Alzheimer's disease, and methods of use thereof.

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PROTEIN MARKERS FOR ASSESSING ALZHEIMER'S DISEASE

NºPublicación: IL298100A 01/01/2023

Solicitante:

UNIV HONG KONG SCIENCE & TECH [HK]

AU_2021273299_PA

Resumen de: WO2021228125A1

The present invention provides protein markers present in a person's blood sample (such as a plasma, serum, or whole blood sample) that are associated with the Alzheimer's Disease (AD), diagnostic and treatment methods for AD, and kits for diagnosing AD.

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COROSOLIC ACID CAPABLE OF IMPROVING INSULIN RESISTANCE/SENSITIVITY AND ENHANCING METABOLIC FUNCTION AND ANALOGUE THEREOF

NºPublicación: WO2022270112A1 29/12/2022

Solicitante:

MATSUYAMA FUTOSHI [JP]

Resumen de: WO2022270112A1

[Abstract] Corosolic acid improves insulin resistance and recovers an insulin function that is deteriorated with age. As a result, the insulin sensitivity in an aged person is improved and the metabolism in all cells gets active. [Problem] The problem to be solved by the present invention is to alleviate and ameliorate an adult disease, a lifestyle-related disease, dementia and the like associated with insulin resistance and achieve a long healthy life-span by corosolic acid and an analogue thereof. There is a finding about a composition which recovers a function inherent to insulin again against the slowing down of an insulin reaction or insulin resistance that is believed as a main cause of an adult disease, a lifestyle-related disease, dementia or the like and is consequently useful for the delay of progression or prevention of an adult disease, a lifestyle-related disease, dementia/Alzheimer's disease or the like, and an idea about a specific method is proposed.

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MODIFIED IMMUNOGLOBULINS FOR TARGETING AMYLOID DEPOSITS

NºPublicación: US2022411489A1 29/12/2022

Solicitante:

ATTRALUS INC [US]
UNIV TENNESSEE RES FOUND [US]

CN_115298214_PA

Resumen de: US2022411489A1

Provided herein are modified immunoglobulins comprising an amyloid reactive peptide joined to an antibody, as well as humanized antibodies that bind to human amyloid fibrils and antibody-peptide fusion proteins. Also provided herein are methods of treating amyloid-based diseases by administering a modified immunoglobulin, humanized antibody, or antibody-peptide fusion protein.

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Silver Nanoneedles for Sustained DC Current Single Nanopore Measurements

NºPublicación: US2022412949A1 29/12/2022

Solicitante:

UNIV CINCINNATI [US]

Resumen de: US2022412949A1

A composition having one or more nanoneedles is provided, where each nanoneedle has a silver tip and one or more of the silver tips comprise an AgCl layer. In one approach, one or more of the silver tips further include a layer of thiol-polyethylene glycol. A method of resistive pulse detection involving a protein pore is also provided. The method involves reconstituting one or more protein pores in a lipid membrane formed on the tip of a nanoneedle, then applying a potential across the membrane and detecting resistive pulses.

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DETECTION METHOD OF CIRCULATING BMP10 (BONE MORPHOGENETIC PROTEIN 10)

NºPublicación: EP4107182A1 28/12/2022

Solicitante:

UNIV MAASTRICHT [NL]
HOFFMANN LA ROCHE [CH]
ROCHE DIAGNOSTICS GMBH [DE]
ACAD ZIEKENHUIS MAASTRICHT [NL]

CN_115190886_PA

Resumen de: WO2021165465A1

The present invention relates to a method for assessing atrial fibrillation in a subject, said method comprising the steps of determining the amount of BMP10 in a sample from the subject, and comparing the amount of BMP10 to a reference amount, whereby atrial fibrillation is to be assessed. Moreover, the present invention relates to a method for diagnosing heart failure based on the determination of BMP10 in a sample from a subject. Further, the present invention relates to a method for predicting the risk of a subject of hospitalization due to heart failure based on the determination of a BMP10-type peptide in a sample from a subject. The present invention further pertains to antibodies which bind to one or more BMP10-type peptides such as NT-proBMP10.

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ANTI-PHF-TAU ANTIBODIES AND USES THEREOF

NºPublicación: JP2022191383A 27/12/2022

Solicitante:

ヤンセンバイオテツク,インコーポレーテツド

US_2021179696_A1

Resumen de: US2018265575A1

Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.

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Antibodies specific for hyperphosphorylated tau and methods of use thereof

NºPublicación: NZ748983A 23/12/2022

Solicitante:

H LUNDBECK AS

US_2022177557_A1

Resumen de: NZ748983A

The present invention relates to a class of monoclonal antibody that specifically binds the phosphorylated serine 396 residue on pathological hyperphosphorylated (PHF) tau (pS396) with improved affinity, as well as to methods of using these molecules and their tau binding fragments in the treatment of Alzheimer s disease and other tauopathies.

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NEURONAL VIABILITY FACTOR AND USE THEREOF

NºPublicación: US2022404376A1 22/12/2022

Solicitante:

INST NAT SANTE RECH MED [FR]
CENTRE NAT RECH SCIENT [FR]

US_2020174023_A1

Resumen de: US2022404376A1

The present invention concerns a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound selected in the group comprising (i) a polypeptide comprising an amino acid sequence selected in the group comprising the amino acid sequence of the long isoform in Homo sapiens of the RdCVF2 gene (SEQ ID NO: 10), orthologs, derivatives and fragments thereof, (ii) a polynucleotide coding for said polypeptide, (iii) a vector comprising said polynucleotide, and (iv) a host cell genetically engineered expressing said polypeptide; the use of such a composition for the manufacture of a medicament for treating and/or preventing a neurodegenerative disorder in a subject; and a method of testing a subject thought to have or be predisposed to having a neurodegenerative disorder.

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METHODS OF TREATING DEMENTIA ASSOCIATED WITH ALZHEIMER'S DISEASE WITH PROTECTIVE PROTEIN/CATHEPSIN A (PPCA)

NºPublicación: US2022406435A1 22/12/2022

Solicitante:

ST JUDE CHILDRENS RES HOSPITAL [US]

US_2020087704_A1

Resumen de: US2022406435A1

Methods are provided for the prognosis, diagnosis and treatment of various pathological states, including cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. The methods provided herein are based on the discovery that various proteins with a high level of sialylation are shown herein to be associated with disease states, such as, cancer, chemotherapy resistance and dementia associated with Alzheimer's disease. Such methods provide a lysosomal exocytosis activity profile comprising one or more values representing lysosomal exocytosis activity. Also provided herein, is the discovery that low lysosomal sialidase activity is associated with various pathological states. Thus, the methods also provide a lysosomal sialidase activity profile, comprising one or more values representing lysosomal sialidase activity. A lysosomal sialidase activity profile is one example of a lysosomal exocytosis activity profile.

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BIOMARKERS AND TREATMENTS OF ALZHEIMER'S DISEASE AND MILD COGNITIVE IMPAIRMENT

Nº publicación: US2022402979A1 22/12/2022

Solicitante:

AXON NEUROSCIENCE SE [CY]

JP_2022547513_PA

Resumen de: US2022402979A1

The disclosure provides immunogenic peptides, compositions, means, and methods for treating Alzheimer's disease or mild cognitive impairment. The disclosure further provides means and methods for diagnosing patients, selecting patients for treatment, and/or evaluating the efficacy of treatment for Alzheimer's disease or mild cognitive impairment.

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