NANOFÁRMACOS

VolverVolver

Resultados 212 resultados LastUpdate Última actualización 17/08/2019 [16:04:00] pdf PDF

Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days

Página1 de 9 nextPage   por página


Use of nano-material composition DG-5 for the treatment of drug-resistant bacteria

NºPublicación: US2019247429A1 15/08/2019

Solicitante:

CHANGSHA DIGU NANO BIOTECHNOLOGY CO LTD [CN]

WO_2018010403_A1

Resumen de: US2019247429A1

The present invention is in the field of medicinal technologies, and provides a nano-material composition DG-5 for use as a medicament against drug-resistant bacteria. The composition showed a strong inhibitory effect against several super drug-resistant bacteria (superbugs), and thus can be used for manufacture of novel effective antibacterial drugs. The mediocament can be administered externally, orally, subcutaneously, or via intravenous or intramuscular injection.

traducir

DENDRIMER BASED NANODEVICES FOR THERAPEUTIC AND IMAGING PURPOSES

NºPublicación: US2019247407A1 15/08/2019

Solicitante:

UNIV WAYNE STATE [US]
THE US SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICE [US]

US_2015141350_A1

Resumen de: US2019247407A1

A nanodevice composition including N-acetyl cysteine linked to a dendrimer, such as a PAMAM dendrimer or a multiarm PEG polymer, is provided. Also provided is a nanodevice for targeted delivery of a compound to a location in need of treatment. The nanodevice includes a PAMAM dendrimer or multiarm PEG polymer, linked to the compound via a disulfide bond. There is provided a nanodevice composition for localizing and delivering therapeutically active agents, the nanodevice includes a PAMAM dendrimer or multiarm PEG polymer and at least one therapeutically active agent attached to the PAMAM dendrimer or multiarm PEG polymer. A method of site-specific delivery of a therapeutically active agent, by attaching a therapeutically active agent to a PAMAM dendrimer or multiarm PEG polymer using a disulfide bond, administering the PAMAM dendrimer or multiarm PEG polymer to a patient in need of treatment, localizing the dendrimer or multiarm PEG polymer to a site in need of treatment, and releasing the therapeutically active agent at the site in need of treatment.

traducir

COMPOSITIONS AND METHODS FOR GENE EDITING FOR HEMOPHILIA A

NºPublicación: US2019247517A1 15/08/2019

Solicitante:

CASEBIA THERAPEUTICS LTD LIABILITY PARTNERSHIP [US]

WO_2019079527_PA

Resumen de: US2019247517A1

Provided include materials and methods for treating Hemophilia A in a subject ex vivo or in vivo. Also provided include materials and methods for knocking in a FVIII-encoding gene in a genome, in particular the locus of albumin gene.

traducir

BIONANOCOMPOSITE SYNTHESIS FOR WOUND HEALING

NºPublicación: US2019247514A1 15/08/2019

Solicitante:

IMAM ABDULRAHMAN BIN FAISAL UNIV [SA]

Resumen de: US2019247514A1

A method for treating a burn, lesion, lacuna, or wound comprising contacting the burn, lesion, or wound with a chitosan-functionalized silica sphere (“CHI-HSS”). Chitosan-functionalized silica spheres and pharmaceutical compositions containing them.

traducir

PROSTACYCLIN COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF

NºPublicación: US2019248731A1 15/08/2019

Solicitante:

INSMED INC [US]

JP_2019056007_A

Resumen de: US2019248731A1

Prostacyclin compounds and compositions comprising the same are provided herein. Specifically, prostacyclin compounds comprising treprostinil covalently linked to a linear C3-C18 alkyl, branched C5-C18 alkyl, linear C2-C18 alkenyl, branched C3-C18 alkenyl, aryl, aryl-C1-C18 alkyl or an amino acid or a peptide (e.g., dipeptide, tripeptide, tetrapeptide) are described. The linkage, in one embodiment, is via a carbamate, amide or ester bond. Prostacyclin compounds provided herein can also include at least one hydrogen atom substituted with at least one deuterium atom. Methods for treating pulmonary hypertension (e.g., pulmonary arterial hypertension) and portopulmonary hypertension are also provided.

traducir

POLYMER-METAL OXIDE COMPLEX, PREPARATION METHOD THEREFOR, AND APPLICATIONS

NºPublicación: US2019247524A1 15/08/2019

Solicitante:

JIANGSU NANOFE BIOMEDICAL TECH CO LTD [CN]

GB_2568434_A

Resumen de: US2019247524A1

A polymer-metal oxide complex, comprising a metal oxide particle located at the core and a polymer modified on the surface of the metal oxide particle, the polymer being provided with functional groups capable of bonding with a metal in the metal oxide, the density of the binding sites of the polymer and the surface of the metal oxide particle being greater than two sites/square nanometer. Also disclosed are a preparation method for the polymer-metal oxide complex, and applications of the polymer-metal oxide complex as a nuclear magnetic resonance contrast agent and as an iron supplement. The polymer-metal oxide complex has a significantly extended in vivo circulation time and effectively overcomes the defect that existing contrast agents cause hypersensitivity, which in addition to the superparamagnetic and iron metabolism participation functions of the complex, enables the complex to be applied as a magnetic resonance imaging contrast agent and as an iron supplement treating iron-deficiency anaemia.

traducir

POLYMER-CLAY COMPOSITE AND ORGANOCLAY

NºPublicación: US2019247542A1 15/08/2019

Solicitante:

UNIV SOUTHAMPTON [GB]

US_2017043058_A1

Resumen de: US2019247542A1

The invention relates to a polymer-clay composite material comprising clay nanoparticles and a polymer, and wherein (a) the polymer comprises phosphate and/or phosphonate ligands; or (b) the polymer-clay composite further comprises linker molecules comprising a phosphate or phosphonate ligand, wherein the linker molecules are arranged to be anchored to the polymer. The invention further relates to organoclays, BMP-clay composite material. Uses, treatments, and manufacturer of the material are also provided.

traducir

ANTIBODY-MEDIATED AUTOCATALYTIC, TARGETED DELIVERY OF NANOCARRIERS TO TUMORS

NºPublicación: US2019247515A1 15/08/2019

Solicitante:

UNIV YALE [US]

JP_2019518040_A

Resumen de: US2019247515A1

DNA-targeted nanocarriers for encapsulating an active agent and delivering it to extracellular DNA are provided. The nanocarriers, for example, polymeric particles, liposomes, and multilamellar vesicles have targeting moiety that targets DNA conjugated thereto. The targeting moiety that targets DNA is typically an antibody, or variant, fragment, or fusion protein derived therefrom that binds to DNA or nucleosomes. The targeting moiety can be a circulating autoantibody that binds DNA such as those commonly found in patients with SLE. In some embodiments, the targeting moiety is antibody 3E10 or a variant, fragment, or fusion protein derived therefrom. Pharmaceutical compositions, methods of use, and dosage regimens are also provided.

traducir

NANOPARTICLE FORMULATIONS AND METHODS OF MAKING AND USING THEREOF

NºPublicación: US2019247357A1 15/08/2019

Solicitante:

ABRAXIS BIOSCIENCE LLC [US]

CN_109996527_A

Resumen de: US2019247357A1

The present invention provides compositions comprising nanoparticles comprising (a) a hydrophobic drug, (b) an albumin, and (c) a bioactive polypeptide. The present invention also provides method of making compositions comprising nanoparticles comprising (a) a hydrophobic drug, (b) an albumin, and (c) a bioactive polypeptide. Further provided are methods of use, pharmaceutical compositions, medicines, and kits thereof.

traducir

DEXAMETHSONE PRODRUG COMPOSITIONS AND USES THEREOF

NºPublicación: US2019247311A1 15/08/2019

Solicitante:

INTERFACE BIOLOGICS INC [CA]

WO_2019148293_A1

Resumen de: US2019247311A1

The disclosure features dexamethasone prodrug dimers of dexamethasone and pharmaceutical compositions thereof useful for, e.g., the extended release of a drug and for the treatment of a disease or condition.

traducir

METHODS AND COMPOSITIONS FOR POTENTIATING STEM CELL THERAPIES

NºPublicación: US2019247358A1 15/08/2019

Solicitante:

OJAI ENERGETICS PBC [US]

Resumen de: US2019247358A1

The present disclosure relates to cannabinoid compositions used in combination with stem cell therapies. These compositions can be encapsulated (e.g., microencapsulated). In particular, these compositions can be administered to a subject, such as through oral consumption or topical treatment.

traducir

PROTEINOID COMPOUNDS, PROCESS OF PREPARING SAME AND USES THEREOF

NºPublicación: US2019247318A1 15/08/2019

Solicitante:

UNIV BAR ILAN [IL]

US_2017042827_A1

Resumen de: US2019247318A1

Proteinoid compounds characterized by a molecular weight (Mw) of at least 15,000 Da, processes of preparing such compounds and methods of use thereof, are provided. A method of monitoring the presence and metastases of cancer in a body of an individual is further disclosed.

traducir

Copper Sulfide Perfluorocarbon Nanocarriers

NºPublicación: US2019247525A1 15/08/2019

Solicitante:

GEORGIA TECH RES INST [US]

Resumen de: US2019247525A1

The present invention provides nanocarrier compositions, for example, copper sulfide perfluorocarbon nanocarrier compositions, and methods of making the same. The compositions are useful for imaging, diagnostics, therapy and for other uses.

traducir

NUCLEIC ACID-PEPTIDE CAPSULE COMPLEXES

NºPublicación: US2019246632A1 15/08/2019

Solicitante:

KANSAS STATE UNIV RESEARCH FOUNDATION [US]

CA_3035356_A1

Resumen de: US2019246632A1

Described herein are nucleic acid-peptide capsule complexes or nanoparticles comprising pre-formed peptide capsules and nucleic acids bound the exterior surface of the capsule, such that the wrap around the capsule membrane. The peptide capsules comprise bilayer membrane defining a liquid-receiving interior space and comprises a plurality of branched, amphipathic peptides. Method of making and using such complexes for delivering nucleic acids in vivo and in vitro are also described.

traducir

ANTI-BACTERIAL APPLICATIONS OF POLY-N-ACETYLGLUCOSAMINE NANOFIBERS

NºPublicación: US2019247410A1 15/08/2019

Solicitante:

MARINE POLYMER TECH INC [US]

JP_2018203766_A

Resumen de: US2019247410A1

Described herein are compositions comprising shortened fibers of poly-N-acetylglucosamine and/or a derivative thereof (“sNAG nanofibers”) and anti-bacterial applications of such compositions. The sNAG nanofibers may be formulated into compositions for the prevention and/or treatment of bacterial infections and diseases associated with such infections. Regimens employing such compositions are also described.

traducir

COMPOSITIONS AND METHODS FOR BILE ACID PARTICLES

NºPublicación: US2019247313A1 15/08/2019

Solicitante:

UNIV UTAH RES FOUND [US]

KR_20170125793_A

Resumen de: US2019247313A1

Therapeutic compositions are disclosed which contain a therapeutic agent and a bile acid or bile acid conjugate. The compositions can be absorbed via enterohepatic circulation. The compositions include a cationic moiety and an anionic polymer, which are coupled through electrostatic interactions. The therapeutic compositions can be used for the treatment of diseases or disorders.

traducir

ULTRASOUND TRIGGERED RELEASE FROM METAL ORGANIC FRAMEWORK NANOCARRIERS

NºPublicación: US2019247502A1 15/08/2019

Solicitante:

AMERICAN UNIV OF SHARJAH [AE]

Resumen de: US2019247502A1

Metal-organic frameworks for drug delivery systems, therapeutic compositions including the metal-organic frameworks, and method of treating cancer using the therapeutic compositions are disclosed. According to some embodiments, a method of treating cancer in a mammal may include: providing a therapeutic composition containing a nanocarrier with a drug-loaded metal organic framework; delivering the therapeutic composition to the mammal; allowing the nanocarrier to circulate throughout a circulatory system of the mammal for a time sufficient to allow aggregation of a therapeutic quantity of the nanocarrier at a treatment area; and applying ultrasound to the treatment area such that the nanocarrier releases the drug in the treatment area.

traducir

SPHERICAL MICROPARTICLES

NºPublicación: EP3523021A1 14/08/2019

Solicitante:

BASF SE [DE]

Resumen de: WO2018065481A1

The present invention relates to compositions of spherical microparticles composed of a wall material and at least one cavity containing a gas and/or a liquid which contain pores at their surface, wherein the spherical microparticles have an average particle diameter of 10 - 600 µm and wherein at least 80% of those microparticles whose particle diameters deviate from the average particle diameter of the microparticles of the composition by not more than 20% each have on average at least 10 pores whose diameter is in the range from 1/5000 to 1/5 of the average particle diameter and furthermore the diameter of these pores is at least 20 nm, wherein the wall material consists of a composition containing at least one aliphatic-aromatic polyester and the wall material has a solubility at 25°C of at least 50g/l in dichloromethane, to a process for the production thereof and to the use thereof.

traducir

COATING OF NANOPARTICLE SURFACES WITH CYCLOPEPTIDES FOR IMPROVING DELIVERY OF AGENTS VIA THE ORAL ROUTE

NºPublicación: EP3522866A1 14/08/2019

Solicitante:

RUPRECHT KARLS UNIV HEIDELBERG [DE]

WO_2018065085_PA

Resumen de: WO2018065085A1

The present invention relates to a surface-coated nanoparticle comprising biodegradable polymer chains and cyclopeptides, wherein the cyclopeptides are covalently attached to the biodegradable polymer chains forming the nanoparticle, thereby coating the surface of the nanoparticle. The present invention further relates to the use of said surface-coated nanoparticle as a capsule for an agent for improving the oral delivery thereof. In another aspect, the present invention relates to the surface-coated nanoparticle for use in the treatment or prevention of a disorder or disease in a patient, wherein the treatment or prevention is achieved by mucosal uptake of the surface-coated nanoparticle via the oral route.

traducir

POLYMERIZABLE QUANTUM DOT NANOPARTICLES AND THEIR USE AS THERAPEUTIC, ABLATION AND TATTOOING AGENTS

NºPublicación: EP3522926A1 14/08/2019

Solicitante:

NANOCO TECHNOLOGIES LTD [GB]

KR_20190055149_A

Resumen de: WO2018065860A1

The present disclosure relates to quantum dot nanoparticles conjugated to ligands, and in particular quantum dot nanoparticles wherein each nanoparticle is conjugated to a polymenzable ligand. The present disclosure also relates to methods of making such conjugated quantum dot nanoparticles, and the use of such conjugated quantum dot nanoparticles as therapeutic agents, ablation agents and tattooing agents.

traducir

COMPOSITIONS AND METHODS FOR PROTEIN EXPRESSION AND DELIVERY

NºPublicación: EP3523321A1 14/08/2019

Solicitante:

NAT UNIV SINGAPORE [SG]

CN_110023328_A

Resumen de: WO2018067075A1

The present invention relates to methods and compositions that provide an environment that promotes enhanced protein expressing and/or folding. More particularly, the present invention provides engineered thermostable ferritin assemblies comprising at least one modified ferritin subunit, wherein the least at least one modified ferritin subunit lacks an unstructured carboxy-terminal sequence that is present in a wildtype ferritin subunit and wherein the engineered assembly is stable at lower salt concentrations that a wildtype ferritin assembly. The invention is exemplified by a ferritin assembly derived from hyperthermophilic Archaeoglobus fulgidus. Also claimed are nucleic acids, compositions, kits and methods of encapsulating a polypeptide, delivering and administering the said engineered ferritin assembly to a subject.

traducir

COMPOUNDS AND METHODS FOR ACTIVATING TIE2 SIGNALING

NºPublicación: EP3522906A1 14/08/2019

Solicitante:

ASCLEPIX THERAPEUTICS INC [US]
UNIV JOHNS HOPKINS [US]

US_2019225670_A1

Resumen de: WO2018067646A1

The present invention in various aspects and embodiments, involves methods for treating Tie2 -related vascular permeability by administering one or more collagen IV-derived biomimetic peptides and involves compositions for treating Tie2-related vascular permeability comprising one or more collagen IV-derived biomimetic peptides. Such peptides can promote the Tie2 agonist activities of Angiopoietin 2 (Ang2), thereby stabilizing vasculature and/or lymphatic vessels.

traducir

NANOPARTICLE FORMULATIONS AND METHODS OF MAKING AND USING THEREOF

NºPublicación: EP3522854A1 14/08/2019

Solicitante:

ABRAXIS BIOSCIENCE LLC [US]

US_2019247357_A1

Resumen de: WO2018071399A1

The present invention provides compositions comprising nanoparticles comprising (a) a hydrophobic drug, (b) an albumin, and (c) a bioactive polypeptide. The present invention also provides method of making compositions comprising nanoparticles comprising (a) a hydrophobic drug, (b) an albumin, and (c) a bioactive polypeptide. Further provided are methods of use, pharmaceutical compositions, medicines, and kits thereof.

traducir

ULTRALOW-POWER NEAR INFRARED LAMP LIGHT OPERABLE TARGETED ORGANIC NANOPARTICLE PHOTODYNAMIC THERAPY

NºPublicación: EP3522870A1 14/08/2019

Solicitante:

UNIV MASSACHUSETTS [US]

US_2019224221_A1

Resumen de: WO2018071256A1

The invention provides a novel class of NIR-absorbing biocompatible organic nanoparticles for effective imaging, targeting and treatment of deep-tissue cancers or tumors. The invention enables a new platform for precise cancer- or tumor-targeting theranostics and clinical cancer treatment.

traducir

一种声控肿瘤高效协同免疫治疗可视化微纳载体系统及其制备方法、应用

Nº publicación: CN110115764A 13/08/2019

Solicitante:

\u5929\u6D25\u5927\u5B66

Resumen de: CN110115764A

本发明提供一种声控肿瘤高效协同免疫治疗可视化微纳载体系统及其制备方法、应用。所述系统包括由pH/还原双敏感聚合物组成的智能模块;由声敏蛋白MscL基因组成的声控模块;由T细胞和DC细胞抗体组成的靶向模块;由微泡负载超声成像剂组成的可视模块。所述系统有望通过基因高效递送、声控精准启动、免疫协同集成同时实现声控免疫应答增强、免疫逃逸解除和免疫过程调控的协同,进一步实现原位与全身免疫应答的协同,并产生免疫记忆,从而最大程度实现肿瘤的原位治疗、转移抑制和复发预防。

traducir

Página1 de 9 nextPage por página

punteroimgVolver