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Resultados 74 resultados LastUpdate Última actualización 27/01/2023 [13:23:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 15 días / Applications published in the last 15 days



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一种包裹间充质干细胞膜的载药磁性纳米颗粒及其制备方法和应用

NºPublicación: CN115634212A 24/01/2023

Solicitante:

温州医科大学附属第二医院(温州医科大学附属育英儿童医院)

Resumen de: CN115634212A

本发明公开了一种包裹间充质干细胞膜的载药磁性纳米颗粒及其制备方法和应用,制备方法包括:步骤一、制备Fe3O4磁性纳米颗粒;步骤二、制备顺铂前药DSP;步骤三、制备Fe3O4@PEI磁性纳米颗粒;步骤四、制备Fe3O4@PEI‑DSP磁性纳米颗粒;步骤五、制备间充质干细胞膜;步骤六、将Fe3O4@PEI‑DSP磁性纳米颗粒与间充质干细胞膜分别进行超声波处理后混合,采用囊泡发生器对混合溶液进行挤压,获得包裹间充质干细胞膜的载药磁性纳米颗粒。本发明的包裹间充质干细胞膜的载药磁性纳米颗粒包含间充质干细胞膜表面趋化因子受体,保留了间充质干细胞独特的肿瘤趋化性,可特异性地趋化至肿瘤细胞部位从而发挥靶向肿瘤治疗的作用,具有制备方法简易、成本低廉、应用广泛等优点。

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一种人血清白蛋白为载体递送莲子心生物碱的纳米粒及其制法和应用

NºPublicación: CN115634211A 24/01/2023

Solicitante:

南京中医药大学

Resumen de: CN115634211A

本发明公开了一种人血清白蛋白为载体递送莲子心生物碱的纳米粒及其制法和应用,所述纳米粒通过机械搅拌法合成,主要是利用人血清白蛋白的疏水口袋包载疏水性的莲子心生物碱,所述纳米粒是由人血清白蛋白和莲子心生物碱构成。本发明制备工艺简单、条件温和、成本低廉,制得的纳米粒具有高度内源性、高靶向性、治疗机制互补、生物安全性等优点。该纳米药物递送平台能够实现多种疏水性中药单体的递送,实现对于复杂的进行性疾病如肿瘤等疾病的协同靶向治疗,具有良好的应用前景。

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一种基于牛血清白蛋白-银复合纳米颗粒的制备

NºPublicación: CN115634238A 24/01/2023

Solicitante:

西南大学

Resumen de: CN115634238A

本发明涉及一种基于牛血清白蛋白‑银复合纳米颗粒的制备,包括:以牛血清白蛋白为纳米笼,通过静电相互作用使银离子在纳米笼中成核生长为银的复合纳米颗粒;对所得最终产品进行体外性能评价。本发明方法简单易行,制备得到的牛血清白蛋白‑银复合纳米颗粒具有良好的稳定性和多功能性。

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一种脂质纳米颗粒及其制备方法和应用

NºPublicación: CN115624539A 20/01/2023

Solicitante:

首都医科大学附属北京朝阳医院

Resumen de: CN115624539A

本发明涉及生物医药技术领域,尤其是涉及一种脂质纳米颗粒及其制备方法和应用,该脂质纳米颗粒包含:阳离子脂质体和包被于阳离子脂质体中的复合物,所述复合物至少由一种反义寡核苷酸与聚乙烯亚胺复合形成。本发明的技术方案通过采用阳离子脂质体包被由反义寡核苷酸与聚乙烯亚胺形成的复合物,获得脂质纳米颗粒,以提高反义寡核苷酸作药物的稳定性和递送效率。

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一种新型蟾毒它灵功能化仿生纳米复合制剂及其制备方法和应用

NºPublicación: CN115624623A 20/01/2023

Solicitante:

湖南万欧科技有限公司

Resumen de: CN115624623A

本发明涉及一种新型蟾毒它灵功能化仿生纳米复合制剂,该仿生纳米复合制剂包括中空普鲁士蓝纳米颗粒(HPB NPs)、蟾毒它灵(CS‑5)、聚乙烯亚胺(PEI,1.8kDa)、二氢卟吩e6(Ce6)和仿生膜,蟾毒它灵物理装封于中空普鲁士蓝纳米颗粒内,聚乙烯亚胺修饰在中空普鲁士蓝纳米颗粒表面,二氢卟吩e6修饰于中空普鲁士蓝纳米颗粒的聚乙烯亚胺层上,且二氢卟吩e6与聚乙烯亚胺修饰的中空普鲁士蓝纳米颗粒通过酰胺键共价连接得到纳米复合制剂,最后仿生膜伪装于纳米复合制剂最外层得到粒径为100nm~130nm的仿生纳米复合制剂。本发明中的仿生纳米复合制剂具有高肿瘤渗透性及优异的肿瘤靶向性,且能够高效产氧缓解肿瘤微环境,可用于有效的化疗/光动力联合抗肿瘤治疗。

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仿生型巨噬细胞膜包覆纳米配位聚合物及制备方法与其在肝脏缺血再灌注损伤中的应用

NºPublicación: CN115624538A 20/01/2023

Solicitante:

上海交通大学医学院附属瑞金医院

Resumen de: CN115624538A

本发明公开了仿生型巨噬细胞膜包覆纳米配位聚合物及制备方法与其在肝脏缺血再灌注损伤中的应用。该仿生型巨噬细胞膜包覆纳米配位聚合物为涂覆有巨噬细胞膜的由地塞米松磷酸钠和铁离子通过配位作用构建的纳米配位聚合物。该仿生型巨噬细胞膜包覆纳米配位聚合物为器官移植的缺血再灌注损伤治疗提供了一种新的治疗选择。

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AQUEOUS BUMETANIDE-CONTAINING LIQUID

NºPublicación: WO2023285009A1 19/01/2023

Solicitante:

DRIPEL B V [NL]

Resumen de: WO2023285009A1

The invention relates to an aqueous bumetanide-containing liquid that can suitably be used for transmucosal administration of bumetanide, said aqueous liquid comprising: - 0.3-5 wt.% bumetanide; - 2-30 wt.% of a non-ionic surfactant having a HLB of more than 10; and - 65-94 wt.% water; wherein the liquid has a pH at 25°C in the range of 5-9 and wherein each of the bumetanide and the non-ionic surfactant is dissolved and/or contained in colloidal particles having a diameter of less than 50 nm. The aqueous liquid of the present invention offers the advantage that it can accommodate relatively high concentrations of bumetanide. Excellent bioavailability can be achieved upon transmucosal administration of the aqueous bumetanide-containing liquid. The aqueous liquid further offers the highly desirable advantage that it does not cause irritation, e.g. stinging or itching, when administered in this manner.

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SINGLE CHAIN VARIABLE FRAGMENT (SCFV) MODIFIED LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF

NºPublicación: WO2023287861A2 19/01/2023

Solicitante:

GENERATION BIO CO [US]

Resumen de: WO2023287861A2

Provided herein are pharmaceutical compositions comprising a lipid nanoparticle (LNP) and a therapeutic nucleic acid (TNA), wherein the LNP comprises a single-chain variable fragment (scFv) linked to the LNP, and at least one pharmaceutically acceptable excipient. The scFv is capable of binding an antigen present on the surface of a cell, advantageously providing LNP compositions that target only those cells or tissues expressing the receptor.

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TARGETED GLYCOSAMINOGLYCAN-PARTICLES AND METHODS OF USE

NºPublicación: WO2023287912A1 19/01/2023

Solicitante:

UNIV OKLAHOMA [US]

Resumen de: WO2023287912A1

Compositions containing compositions of heparosan polymers linked to a particle, such as a metallic or polymeric or lipid-containing nanoparticle are described, for use in cell delivery applications.

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RNA ADSORBED ONTO LIPID NANO-EMULSION PARTICLES AND ITS FORMULATIONS.

NºPublicación: WO2023286076A1 19/01/2023

Solicitante:

GENNOVA BIOPHARMACEUTICALS LTD [IN]

Resumen de: WO2023286076A1

RNA adsorbed onto lipid nano-emulsion particles and its formulations. The present invention relates, a method of preparing a liquid formulation of RNA complexed with lipid nano-emulsion particles or nano-carriers. It particularly provides a method for preparation of the RNA adsorbed onto lipid nano-emulsion particles in liquid and the formulations of said RNA complexes as such.

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COMPOSITION FOR PREVENTING OR TREATING BONE DISEASES CONTAINING NANOVESICLES DERIVED FROM DIOSCOREA JAPONICA THUNB

NºPublicación: WO2023287159A1 19/01/2023

Solicitante:

KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND [KR]
ANDONG NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION [KR]

Resumen de: WO2023287159A1

The present invention relates to a composition for preventing or treating bone diseases containing nanovesicles derived from Dioscorea japonica Thunb. As the nanovesicles isolated from a natural product are nontoxic, and effectively act on the proliferation, differentiation, and bone formation of osteoblasts, the nanovesicles can be utilized for prevention, amelioration or treatment of various bone diseases including osteoporosis. In addition, as the nanovesicles derived from Dioscorea japonica Thunb have a superior osteoblast differentiation and bone formation effect compared to any one component contained in Dioscorea japonica Thunb, such as diosgenin, dioscin, or microvesicles derived from Dioscorea japonica Thunb, it is possible to develop various types of functional food materials by using the nanovesicles, and to contribute to the development of the agricultural economy in areas producing Dioscorea japonica Thunb.

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BRAIN PERMEABLE MULTIFUNCTIONAL SYSTEM AND USES THEREOF

NºPublicación: WO2023286060A1 19/01/2023

Solicitante:

NANOCARRY THERAPEUTICS LTD [IL]

Resumen de: WO2023286060A1

The present invention provides a BBB-permeable multifunctional system for the synchronized delivery of distinct active agents to the brain. The multifunctional system is based on an inorganic core particle which is conjugated through a first polymeric linker to a first active agent; through a second polymeric linker to a second active agent; and through a third polymeric linker to a brain-internalizing transporter moiety. Further provided are a process for preparation of the multifunctional system, pharmaceutical compositions comprising the multifunctional system and uses thereof in therapeutic and/or diagnostic methods.

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CELL NUCLEUS-TARGETING UPCONVERSION FLUORESCENT PROBE, AND PREPARATION METHOD THEREFOR AND USE THEREOF

NºPublicación: WO2023284134A1 19/01/2023

Solicitante:

NANJING NUOYUAN MEDICAL DEVICES CO LTD [CN]

CN_113512415_A

Resumen de: WO2023284134A1

Disclosed in the present invention are a cell nucleus-targeting upconversion fluorescent probe, and a preparation method therefor and the use thereof. The fluorescent probe is of a shell-core structure, wherein the core of the fluorescent probe is an upconversion fluorescent nanoparticle doped with rare-earth ions, the shell of the fluorescent probe is a mesoporous silica coating layer, mesopores of the mesoporous silica coating layer are loaded with a chemotherapeutic drug, and a cell nucleus-targeting ligand is grafted onto the outer surface of the mesoporous silica coating layer. The fluorescent probe provided by the present invention can not only load a chemotherapeutic drug by means of mesoporous channels of the mesoporous silica layer and deliver the chemotherapeutic drug to the cell nucleus in a targeted manner, but can also achieve NIR-vis and NIR-NIR upconversion fluorescence imaging by means of the upconversion fluorescent nanoparticles UCNPs doped with rare-earth ions. The upconversion fluorescent nanoparticles doped with the rare-earth ions have the characteristics of a high sensitivity and skin tissue penetration depth, and achieve cell nucleus targeted delivery and upconversion fluorescent tracing and localization.

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ACETYLCYSTEINE-STABILIZED GOLD NANOCLUSTERS FOR ACUTE KIDNEY INJURY, AND PREPARATION METHOD THEREFOR AND USE THEREOF

NºPublicación: WO2023284408A1 19/01/2023

Solicitante:

UNIV SHENZHEN [CN]

CN_113663082_A

Resumen de: WO2023284408A1

Disclosed in the present invention are acetylcysteine-stabilized gold nanoclusters for acute kidney injury, and a preparation method therefor and the use thereof. The acetylcysteine-stabilized gold nanoclusters (Au NCs-NAC) comprise: gold nanoclusters and acetylcysteine binding to the surface of the gold nanocluster. The Au NCs-NAC of the present invention comprise a surface ligand acetylcysteine and gold nanoclusters protected by the surface ligand. The Au NCs-NAC designed in the present invention are ultra-small, can be effectively enriched in the kidney of mice, can relieve and treat glycerol-induced acute kidney injury by means of removing a large amount of active oxygen or active nitrogen from kidney tubules, has excellent anti-inflammatory capability, and also has a better therapeutic effect than that of acetylcysteine. In addition, the Au NCs-NAC have excellent biocompatibility and biosafety.

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METHOD OF USE FOR APOE PEPTIDES

NºPublicación: WO2023288316A1 19/01/2023

Solicitante:

ANJI PHARMA US LLC [US]

Resumen de: WO2023288316A1

Provided herein are lipid nanoparticle (LX P) compositions and methods related, to the delivery' of biologically active agents and treatment of disease.

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PERCUTANEOUS ABSORPTION AGENT

NºPublicación: WO2023286120A1 19/01/2023

Solicitante:

UNIV KYUSHU NAT UNIV CORP [JP]

Resumen de: WO2023286120A1

In this percutaneous absorption agent, an ionic liquid is finely dispersed in an oil phase, the ionic liquid including a hydrophilic peptide drug, choline, and carboxylate ions obtained by dissociation of hydrogen ions from carboxy groups of a fatty acid. The average particle diameter of the ionic liquid finely dispersed in the oil phase may be 1-100 nm. The centers of particles of the ionic liquid finely dispersed in the oil phase may comprise the hydrophilic peptide drug and one or more selected from the group consisting of choline propionate, choline lactate, and choline formate. The hydrophilic peptide drug may be insulin. The fatty acid may be oleic acid or linoleic acid. The percutaneous absorption agent may further include sorbitan monolaurate in the oil phase.

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PHARMACEUTICAL PREPARATION FOR LOW-TEMPERATURE THERMOTHERAPY, AND PREPARATION METHOD THEREFOR AND USE THEREOF

NºPublicación: WO2023284582A1 19/01/2023

Solicitante:

SICHUAN ENRAY PHARMACEUTICAL TECH CO LTD [CN]

CN_115607667_PA

Resumen de: WO2023284582A1

Disclosed is the use of a nano-carbon iron composite preparation in the preparation of a tumor thermotherapy drug matched with near-infrared light. During low-temperature thermotherapy, the composite preparation can reduce the dosage and reduce the occurrence of adverse reactions, and has a lower temperature when used for thermotherapy, so that surrounding normal tissues cannot be easily damaged, and adverse reactions during nano-carbon thermotherapy are also reduced; and it is further proved that the nano-carbon iron composite preparation and near-infrared irradiation have a synergistic effect. On the basis of the approach and technical effects of low-temperature thermotherapy, the composite preparation has broad clinical significance.

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PORPHYRIN NANOVESICLE WITH FATTY ACID CONJUGATE

NºPublicación: WO2023283732A1 19/01/2023

Solicitante:

UNIV HEALTH NETWORK [CA]

Resumen de: WO2023283732A1

There is described herein a bilayer nanovesicle comprising porphyrin-phospholipid conjugate and a chelator-fatty acid conjugate; wherein the chelator-fatty acid conjugate comprises an aminopolycarboxylic acid conjugated to a single chain fatty acid; and the porphyrin-phospholipid conjugate comprises one porphyrin, porphyrin derivative or porphyrin analog covalently attached to a lipid side chain, preferably at the sn-1 or the sn-2 position, of one phospholipid.

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Formulation to deliver lipophilic active ingredients

NºPublicación: AU2021305974A1 19/01/2023

Solicitante:

PERFORMS S R L

WO_2022009118_A1

Resumen de: AU2021305974A1

The present invention relates to a technological platform for the delivery of lipophilic active ingredients.

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Nanoparticles and methods of manufacture thereof

NºPublicación: AU2021300174A1 19/01/2023

Solicitante:

HILLSTREAM BIOPHARMA INC

WO_2022006271_A2

Resumen de: AU2021300174A1

Provided herein is a biodegradable polymeric nanoparticle formed of hybrid block copolymers comprising a di-block copolymer methoxy-poly(ethylene glycol)-poly(lactic acid) (m-PEG-PLA) and/or a penta-block copolymer poly(lactic acid)-poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol)-poly(lactic acid) (PLA-PEG-PPG-PEG-PLA). Also provided herein are methods of preparing biodegradable polymeric nanoparticles.

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Stem Cell Delivery

NºPublicación: US2023020486A1 19/01/2023

Solicitante:

UNIV MIAMI [US]

WO_2021127639_A1

Resumen de: US2023020486A1

This disclosure relates to systems, compounds and methods for stem cell delivery. More specifically, the disclosure relates a system for promoting tissue regeneration, the system comprising a plurality of stem cells coated with at least one or a plurality of dendrimer nanocarriers that specifically bind to an adhesion molecule. Additionally, the disclosure relates to methods for delivering stem cells to damaged or diseased tissue for stem cell regeneration of the tissue.

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EXOSOMES-BASED THERAPY FOR LIVER FIBROSIS AND OTHER DISEASES WITH FIBROSIS

NºPublicación: US2023013636A1 19/01/2023

Solicitante:

UNIV TEXAS [US]

CN_115297850_PA

Resumen de: US2023013636A1

Provided herein are compositions of lipid-based nanoparticles, such as exosomes, that contain a therapeutic STAT3-targeting inhibitory RNA. Also provided are methods of using such compositions to treat a patient having fibrosis or a disease associated with fibrosis.

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HEMOSTATIC NANOCAPSULES FOR STOPPING BLEEDING, VISUALIZING INJURY, AND DELIVERING DRUGS

NºPublicación: US2023018837A1 19/01/2023

Solicitante:

UNIV MARYLAND [US]

Resumen de: US2023018837A1

One of the significant challenges to translation of intravenously administered nanomaterials has been complement-mediated infusion reactions which can be lethal. Slow infusions can reduce infusion reactions, but slow infusions are not always possible in applications like controlling bleeding following trauma. Nanocapsules based on polyurethane are introduced as candidates that do not substantially activate complement protein C5a and the PEGylation and functionalization of the nanocapsules with the GRGDS peptide to create a new class of hemostatic nanomaterials is disclosed. Advantageously, the nanocapsules substantially avoid complement-mediated infusion reactions, promote faster clotting than controls, maintain maximum clot firmness, and do not activate pro-inflammatory cytokines.

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PHARMACEUTICAL-LOADED NANOCOMPOSITE FOR TREATING PULMONARY INFECTIONS

NºPublicación: US2023019135A1 19/01/2023

Solicitante:

UNIV IMAM ABDULRAHMAN BIN FAISAL [SA]

Resumen de: US2023019135A1

A nanocomposite comprising a nanocarrier, a pharmaceutical compound disposed on a surface of the nanocarrier, and a biocompatible coating disposed on the pharmaceutical compound. The nanocarrier comprises nanotubes of a silicate or aluminosilicate material, preferably halloysite, and nanoparticles of a magnetic transition metal ferrite material of formula MFe2O4, where M is selected from the group consisting of zinc, nickel, copper, manganese, and cobalt, the nanoparticles being disposed on an interior and/or an exterior surface of the nanotubes. The pharmaceutical compound is disposed in the pores and/or on the surface of the nanocarrier by a solution phase impregnation process. The nanomedicinal composition is used in a method of treating pulmonary infections. The nanomedicinal composition may be administered by inhalation.

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Determining Capsule Specificity for Specific Cell Types

Nº publicación: US2023014648A1 19/01/2023

Solicitante:

CAPCO BIO GMBH [DE]
UNIV FREIBURG ALBERT LUDWIGS [DE]

Resumen de: US2023014648A1

The task of the invention is therefore making available transfer capsules that are taken up by the target cell type and permanently or transiently modify the target cell, without exerting any toxic effects on the cell during this process.The solution according to the invention consists of the use of monodisperse cores, so as to produce polyelectrolyte nanocapsules having cell-specific sizes from them. The sizes for hematopoietic cells are in a range of 20-80 nm, preferably in a range of 40-60 nm. In this regard, the sizes of the particles must be in a very narrow range, so as to prevent toxic effects from occurring. In order to keep the toxicity of the nanocapsules low, it is furthermore important to remove the nanoparticles around which the capsules are built up (cores) before use. Methods in this regard are known from the state of the art (for example dissolution by means of EDTA).A further task is the stabilization of the transfer capsules.The solution according to the invention consists in the modification of the capsules, the layers and/or the cargo to be packed, by means of functional groups, which allows stabilization and thereby long-term storage at room temperature.The third task is the targeted introduction of the transfer capsules.The solution according to the invention is a functionalization of the layers by way of chemical modifications and/or supplementing of the layers with antibodies, proteins or peptides.

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