Resumen de: WO2023008787A1

Disclosed herein are a microalga-derived exosome mimetic and a manufacturing method therefor. The method for manufacturing an exosome mimetic of the present invention comprises a step of exclusion processing a buffer solution containing microalgae to prepare nanovesicles. The present invention has the advantage of being able to mass-produce exosome mimetics derived from microalgae on the basis of an extrusion processing method. In particular, the present invention can increase the yield of vesicle production of exosome mimetics derived from microalgae by selectively applying a biolipid surfactant that enhances extrusion processing efficiency.

Resumen de: WO2023006827A1

The invention relates to a method of making a product for human consumption which comprises partially lysed microalgae, said method comprising a) preparing a suspension of microalgae, wherein the microalgae belong to a phylaselected from Chlorophyta, Ochrophyta, and Heterokonta; b) applying a pulsed electric field to the suspension of microalgae, wherein said pulsed electric field has a specific energy input between 25 to 150 kJ per kg suspension (kg sus-1); c) optionally treating the microalgae with enzyme; d) incubating the biomass suspension at 300 rpm, 4-37 °C for 6-48 h e) forming a biomass of partially lysed microalgae; and f) adding the biomass of partially lysed microalgae to a product for human consumption.

Resumen de: RO137238A2

The invention relates to a process for treating residual flows in dairy industry. According to the invention, the process consists in cultivating the Nannochloris sp. microalgae strain in a mixotrophic regime, by using 2.5...10 g/L lactose from whey obtained as a secondary flow during cheese-making, as a source of organic carbon and bubbling of air enriched with 7% CO2 as a source of inorganic carbon, in a photobioreactor equipped with an adjustable lighting source, thermostating and gas bubbling system, in alternating cycles of 12 h of natural/artificial lighting and 12 h of dark, at a temperature of 28 +/-1°C, with the addition of a whey volume corresponding to a concentration of 2.5...10g/L lactose, related to the total volume of nutrient medium, after 7 days of cultivation there resulting a 99...100% reduction of lactose content, up to 96% reduction of chemical oxygen consumption, up to 91% reduction of nitrogen content and 70% reduction of phosphorus content, respectively, and an increase of microalgae biomass quantity of up to 138%.

Resumen de: US2023022786A1

A food composition in the form of an oil-in-water emulsion, comprising 66 to 87 wt % of vegetable oil, less than 1 wt % of microalgal oil, water, microalgal protein, and wherein the composition has a pH of from 2 to 4.8, and wherein the composition is free from egg-derived ingredients.

Resumen de: WO2023001894A1

Provided are compositions containing extracellular vesicles from microalgae (MEVs) that are exogenously loaded with bioactive cargo or other cargo of interest, such as for therapeutic, industrial, diagnostic, and cosmetic uses. The MEVs have a variety of applications as therapeutics, including as vaccines, as anti-cancer therapeutics, as diagnostics, and other such uses.

Resumen de: WO2023001967A1

The present invention relates to a method of preparation of comprising microalgae, in particular Chlorella and products resulting thereof.

Resumen de: US2023025620A1

Extracellular vesicles derived from native, photosynthetic, non-fermenting microalgae are provided. A method for isolating extracellular vesicles from native, photosynthetic, non-fermenting microalgae involving growth, centrifugation and ultracentrifugation steps is also provided. Use of the isolated extracellular vesicles as carriers for deliverling diagnostic, therapeutic, nutraceutic and/or cosmetic agents is further provided.

Resumen de: EP4122330A1

The present invention relates to a method of preparation of comprising microalgae, in particular Chlorella and products resulting thereof.

Resumen de: AU2021232694A1

The present disclosure relates to the field of grouper cultivation, in particular to a method for hatching and culturing grouper using chlorella. The present disclosure applies the self-produced natural green microalgae product to the indoor industrialized culturing of grouper, breaking through the problems of extremely low hatching survival rate of grouper and serious pollution, and opening up the whole process of indoor industrialized culturing, which provides a boost for the transformation to indoor industrialized culturing of grouper. - 23 -

Resumen de: WO2023287381A1

The invention relates to a method of obtaining and producing an antimicrobial bioactive extract from nitrogen stress-grown microalgae. Antimicrobial activity study is carried out with the antimicrobial bioactive extract obtained from the microalgae genus Auxenochlorella protothecoides in the said invention.

Resumen de: US2023013336A1

A method of generating a variant cyanobacterium (e.g., Synechococcus elongatus, in particular S. elongatus sp. PCC11801) for photoautotrophic production of an amino acid (e.g., L-phenylalanine); the variant so produced; a method of extending growth of a culture of a variant cyanobacterium and its photoautotrophic production of an amino acid; and a method of photo-autotrophically producing L-phenylalanine.

Resumen de: WO2021180713A1

The invention relates to a system (1) for producing microalgae in the form of biofilm, comprising a frame (100), a motor (200), at least one support (300) and a ply (400) designed to receive the biofilm and in which: • the frame (100) is configured to support the motor (200), • the motor (200) is configured to impart a rotational movement on at least one support (300); • the at least one support (300) is configured to have a rotational movement about an axis of rotation and to support and impart the rotational movement on the ply (400); • the ply (400) is configured to at least partially surround the at least one support (300), characterized in that the support (300) is configured to have a non-negative buoyancy in a liquid (2).

Resumen de: KR20230007850A

본 발명은 독도 유래의 신규 미세조류 (Scenedesmus rubescens KNUA042) 및 이를 이용한 카로티노이드 생산방법에 관한 것으로, 더욱 자세하게는 독도에서 순수분리한 신규 미세조류 (Scenedesmus rubescens KNUA042)에 최적화된 스트레스 조건을 주어 바이오디젤 및 카로티노이드 생산량을 증대시키는 2단계 배양공정을 통해 바이오연료뿐만 아니라 고부가 제품을 생산할 수 있다.

Resumen de: US2023009188A1

Processes are disclosed for photosynthetic cyanobacterial production of selected proteins and biochemicals within an evolving alkaliphilic microbial consortium.

Resumen de: WO2023275423A1

The present invention relates to an illumination device and incubator for conducting microalgae growth experiments. The device comprises at least one illumination source (10) having LEDs (20) for illuminating the microalgae and a control unit (30) configured for controlling the switching on/off of the LEDs (20) and for varying the light intensity of the LEDs (20). The illumination source (10) comprises RGB LEDs (20) and each RGB LED (20) has a casing that houses a red (21), green (22) and blue (23) LED and a microcontroller (24) that is connected to the control unit (30) for varying the light intensity of the red (21), green (22) and blue (23) LEDs of the RGB LED (20), such that the colour and intensity of the light emitted by each RGB LED (20) is modified by means of the control unit (30).

Resumen de: WO2023277733A1

The invention relates to the field of biotechnology. The microalgae strain Chlorella sp. VADA 2020 was isolated from samples of water from Lake Tamarkul' in the Chanovsky District of the Novosibirsk Oblast and deposited in the Collection of Microalgae of the Institute of Plant Physiology, Russian Academy of Science, under registration number IPPAS С-2048. To cultivate the strain, readily available culture media are used. The invention makes it possible to produce a biomass with a high protein and unsaturated fat content, which is suitable for use for nutritional purposes. More particularly, a biomass is produced having a protein content of 48.1% (by weight) and an unsaturated and mono-unsaturated fatty acid content of 59.1% (of the overall content), which can be used as raw material in the production of food supplements.

Resumen de: WO2021170754A1

The present invention concerns a recombinant microalgae comprising a nucleic acid sequence encoding a recombinant peptide of KTTKS (SEQ ID N°1); a recombinant peptide, polypeptide or protein consisting in repeated units of SEQ ID N°1; or a derivative thereof, said nucleic acid sequence being located in the chloroplast genome of microalgae. It also relates to a method for producing a recombinant peptide of SEQ ID N°1; a recombinant peptide, polypeptide or protein consisting in repeated units of SEQ ID N°1; or a derivative thereof, wherein said method comprises the chloroplast genome transformation of a microalgae with a nucleic acid sequence encoding said recombinant protein, polypeptide or peptide. It further relates to the use of said recombinant peptide, polypeptide or protein for the cosmetic industry.

Resumen de: GB2595644A

Disclosed are modified strains of Chlorella vulgaris having a reduced chitin content. The reduced chitin content may improve digestibility. Also disclosed is a method for producing them. The method involves performing mutagenesis of a parent strain of Chlorella vulgaris. The mutation may be induced with a mutagen such as ethyl methanesulphonate. Also disclosed is a composition comprising algae biomass derived from the modified strains of Chlorella vulgaris and their use in food and/or cosmetics amongst other applications.

Resumen de: WO2022269464A1

A method and system for monitoring invasive species in an algal bioreactor utilizes a low resolution Raman spectrometer (LRRS) system and signal processing methods based upon Support Vector Machine (SVM) models. A spectrum preprocessing algorithm transforms LRRS spectra into normalized spectral data vectors. An ex-situ method is used to analyze a calibration set of known samples of a suspension containing a desired biomass, such as spirolina, together with various concentrations of invasive algal or cyanobacterial species. The ex-situ method generates SVM models and their associated SVM support vectors for classification modeling. An in-situ method uses the SVM models to provide an output vector of probability values corresponding to the presence of invasive species in an unknown sample, and optionally to provide an additional output vector of probability values corresponding to concentrations of the invasive species in the unknown sample.

Resumen de: US2022411744A1

A cyanobacterium transformed using a gene transfer vector. The gene transfer vector includes: a first homologous recombination region homologous to a 5′ side of a target DNA of the cyanobacterium; a second homologous recombination region homologous to a 3′ side of the target DNA; and a DNA fragment introduced into a portion sandwiched between the first homologous recombination region and the second homologous recombination region. A total length of the first homologous recombination region and the second homologous recombination region is 5 kbp or more. The cyanobacterium has a DNA fragment transferred between the 5′ side of the target DNA and the 3′ side of the target DNA.

Resumen de: EP4108225A1

Method for producing cosmetic micro/nano capsules containing at least one antioxidant compound preferably extracted from microalgae and/or cyanobacteria, characterized in that it comprises the following steps:a) solubilising the antioxidant compound in an organic solvent;b) mixing the solution obtained in step a) with an aqueous solution of lysozyme to obtain an antioxidant complex formed by the antioxidant compound and by the lysozyme;c) evaporating at least a part of the organic solvent present in the solution obtained in step b);d) mixing the solution obtained in step c) with an aqueous solution of hyaluronic acid;e) homogenising the solution obtained in step d) to produce a homogeneous suspension of the antioxidant complex;f) adding to the homogeneous suspension obtained in step e) an aqueous solution of a cross-linking compound and performing the homogenisation of the aqueous solution of a cross-linking compound in the homogeneous suspension obtained in step e) to produce the micro/nano capsules containing the antioxidant compound.

Resumen de: KR20220169517A

흰 반점 증후군 바이러스 외피 단백질을 발현하는 형질전환 미세조류를 유효성분으로 포함하는 흰 반점 증후군의 예방 또는 개선용 사료첨가제 조성물 및 이의 용도에 관한 것으로서, 본 발명의 흰 반점 증후군 바이러스(WSSV)의 VP28을 발현하는 형질전환된 클로렐라가, 효과적으로 VP28을 발현하는 것을 확인하였으며, 형질전환 클로렐라를 사료에 혼합하여, 징거미새우(Macrobrachium nipponense) 및 흰다리새우(Litopenaeus vannamei)에 경구투여하였을 때, 효과적으로 WSSV의 감염을 억제하는 것을 확인하였다.

Resumen de: WO2022263580A1

The present invention relates to an anti-inflammatory extract of soil microorganisms or a fraction thereof, wherein the microorganisms comprise one or more selected from Chlorophyta, Xanthophyceae or Cyanobacteria. The invention further relates to compositions comprising two or more of Lyso-DGTS, p-Coumaric acid (ester-linked), oleamide, theophylline, or DGTS. The invention further relates to pharmaceutical compositions comprising the anti-inflammatory extract of soil microorganisms or a fraction thereof or a composition comprising two or more of Lyso-DGTS, p-Coumaric acid (ester-linked), oleamide, theophylline, or DGTS as an active ingredient. The invention further relates to an anti-inflammatory extract of soil microorganisms or a fraction thereof or a pharmaceutical composition comprising an anti-inflammatory extract of soil microorganisms or a fraction thereof or a composition comprising two or more of Lyso-DGTS, p-Coumaric acid (ester-linked), oleamide, theophylline, or DGTS as an active ingredient for use as a medicament, wherein the microorganisms comprise one or more selected from Chlorophyta, Xanthophyceae or Cyanobacteria. The invention further relates to compositions comprising an anti- inflammatory extract of soil microorganisms or a fraction thereof, wherein the microorganisms comprise one or more selected from Chlorophyta, Xanthophyceae or Cyanobacteria.

Resumen de: WO2022264182A1

The present invention concerns an integrated process for producing hydrogen comprising the following steps: a) production of algal biomass by means of a photobioreactor (1) wherein microalgae are fed with water and carbon dioxide and irradiated with light radiation; b) anaerobic digestion for obtaining biomethane and nitrogen digestates by means of an anaerobic digester (2), wherein said anaerobic digestion takes place starting from said algal biomass obtained in said step a); c) steam reforming for obtaining hydrogen, carbon dioxide and heat starting from steam, oxygen and said biomethane obtained in said step b), and subsequent separation of carbon dioxide; and d) alkaline electrolysis of water for obtaining hydrogen and oxygen, by means of electrolysers (4), starting from water heated by the heat obtained in step c) and electric power, wherein the carbon dioxide in said step a) comes from step c) and the oxygen in said step c) comes from step d).

Resumen de: US2022403320A1

The present invention relates to a novel Chlamydomonas strain with an improved oil generation function, the strain of the present invention having useful mycological characteristics as a strain that provides a useful substance, such as a vegetable oil, in a microalga, as the strain has a fast cell growth speed and an excellent lipid generation function compared to conventional strains. In particular, the present invention can provide a vegetable oil with improved stability and a longer preservation period by containing, in a cell, a large amount of antioxidant pigments such as lutein and zeaxanthin, and can, thereby, be usefully used in industries such as food, medicine, cosmetics, etc., which utilize a vegetable oil.