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Resultados 70 resultados LastUpdate Última actualización 17/08/2019 [19:28:00] pdf PDF

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days

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High Sensitivity Impedance Sensor

NºPublicación: US2019250159A1 15/08/2019

Solicitante:

UNIV MISSOURI [US]

US_2016299138_PA

Resumen de: US2019250159A1

Disclosed herein are example embodiments of a transformative sensor apparatus that is capable of detecting and quantifying the presence of a substance of interest such as a specified bacteria within a sample via changes in impedance exhibited by a detection electrode array. In an example embodiment, sensitivity is improved by including a focusing electrode array in a rampdown channel to focus a concentration of the substance of interest into a detection region. The focusing electrodes include an opposing pair of electrodes in a rampdown orientation. The focusing electrode may also include tilted thin film finger electrodes extending from the rampdown electrodes. In another example embodiment, trapping electrodes are positioned to trap a concentration of the substance of interest onto the detection electrode array.

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PROTEIN MATRIX VACCINE COMPOSITIONS INCLUDING POLYCATIONS

NºPublicación: EP3524265A1 14/08/2019

Solicitante:

MATRIVAX INC [MC]

CN_103747798_A

Resumen de: EP3524265A1

The present invention relates to immunogenic compositions containing one or more antigens of interest, one or more carrier proteins, and one or more polycations, wherein the antigen of interest is entrapped with cross-linked carrier protein matrix and one or more polycations, methods of making such vaccines, and methods of vaccine administration.

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BACTERIAL MINICELLS FOR DELIVERING NUCLEIC ACID ADJUVANTS AND METHODS OF USING THE SAME

NºPublicación: EP3522935A1 14/08/2019

Solicitante:

ENGENEIC MOLECULAR DELIVERY PTY LTD [AU]

CN_110022905_A

Resumen de: US2018100159A1

This disclosure provides intact bacterially derived minicells containing nucleic acids adjuvants or plasmids encoding nucleic acids adjuvants that can produce a desired immune response in target cells. This disclosure further provides methods that employ minicells to deliver nucleic acids adjuvants for use in the treatment of diseases, including neoplastic disease and cancer.

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A COMPANION DIAGNOSTIC METHOD FOR USE IN THE TREATMENT OF IRRITABLE BOWEL SYNDROME WITH DIETARY INTERVENTIONS OR FAECAL MICROBIOTA TRANSPLANT

NºPublicación: CN110114471A 09/08/2019

Solicitante:

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AU_2017342088_A1

Resumen de: WO2018069538A1

The present invention provides a diagnostic method which may be used to determine the likelihood that a subject with Irritable Bowel Syndrome (IBS) will respond to treatment with an IBS intervention diet or faecal microbiota transplant (FMT). In particular, the method may be used to predict, or determine the likelihood of, a positive response of the subject with IBS to treatment with an IBS intervention diet or FMT, especially to determine the likelihood that the dietary intervention or FMT may have a positive (i.e. beneficial) effect on the subject's Gl tract, specifically the Gl tract microbiota, or other symptoms or complications of IBS (e.g. reducing severity thereof). The method of the present invention is based on analysing the abundance of certain bacteria in Gl tract samples, e.g. by nucleic acid analysis.

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Compositions and Methods for Treating Disease Using Salmonella T3SS Effector Protein (SipA)

NºPublicación: US2019240286A1 08/08/2019

Solicitante:

UNIV MASSACHUSETTS [US]

US_2017035837_A1

Resumen de: US2019240286A1

The invention provides compositions and methods for reducing one or more symptoms of disease by administering compositions comprising SipA. The invention's compositions and methods are particularly advantageous in reducing symptoms of diseases that are associated with overexpression of P-gp and/or p53. The invention's compositions and methods are useful in reducing cancer symptom and/or cancer multidrug resistance (MDR). The invention provides a method for reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, said SipA is operably conjugated to a nanoparticle. In another embodiment, said cancer comprises cancer cells resistant to at least one cytotoxin.

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Novel VEGFR-2 targeting immunotherapy approach

NºPublicación: AU2018222777A1 08/08/2019

Solicitante:

VAXIMM AG

WO_2018149982_PA

Resumen de: AU2018222777A1

[0081] The present invention relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding a VEGF receptor protein for use in cancer immunotherapy, wherein the cancer is characterized by VEGF receptor protein expressing cancer cells. The present invention further relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding a VEGF receptor protein for use in cancer immunotherapy, wherein the cancer is characterized by VEGF receptor protein expressing cancer cells, and wherein the cancer is selected from the group consisting of glioblastoma, carcinoid cancer, kidney cancer, particularly renal cell carcinoma, thyroid cancer, lung cancer, particularly Non-Small Cell Lung Cancer (NSCLC), breast cancer, ovarian cancer, prostate cancer, gastrointestinal cancer, particularly colorectal cancer, more particularly colon cancer, and skin cancer, particularly melanoma. The present invention further relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding a VEGF receptor protein for use in cancer immunotherapy in a patient comprising at least one VEGF receptor protein expressing cancer cell.

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METHOD FOR REDUCING OR ELIMINATING MICROORGANISMS, PREFERABLY BACTERIA, ON HARD OR SEMI-HARD SURFACES, WHETHER SMOOTH OR POROUS, OF DIFFERENT TYPES OF CONSTRUCTION MATERIAL BY APPLYING A NON-IONISING ELECTROMAGNETIC FIELD

NºPublicación: WO2019148302A1 08/08/2019

Solicitante:

UNIV SANTIAGO CHILE [CL]

Resumen de: WO2019148302A1

The invention relates to a method for reducing or eliminating microorganisms, preferably bacteria, from different surfaces, which comprises applying to said surface a non-ionising electromagnetic field with RF waves emitted between 0.9 and 4 GHz and a stable field with emissions between -35 and 2.5 dBm, under an environment with a relative humidity between 30 and 50% and constant ambient humidity. The surfaces can be selected from: ceilings of dwellings, floor tiles, ceramics, crockery, varnished or unvarnished wooden floors, glass and bathroom surfaces, inter alia. The bacteria are selected from bacteria of the genuses Campylobacter, Staphylococcus, Bacillus and Clostridium. Bacteria selected from the group consisting of Escherichia coli, Salmonella thypimurium and Listeria mococytogenes can also be included, as well as filamentous fungi and yeasts.

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CHEMICAL SYNTHESIS METHOD FOR O-ANTIGEN OLIGOSACCHARIDE OF PLESIOMONAS SHIGELLOIDES SEROTYPE O51

NºPublicación: WO2019144508A1 01/08/2019

Solicitante:

UNIV JIANGNAN [CN]

CN_108558961_A

Resumen de: WO2019144508A1

Disclosed is a chemical synthesis method for an O-antigen oligosaccharide of Plesiomonas shigelloides serotype O51, which method belongs to the field of chemistry. In the present invention, source-rich D-glucose, L-fucose, D-glucosamine, etc., are used as raw materials to prepare three glycosylated building blocks, a synthetic route composed of 11 reaction modules is designed, and the preparation of the target oligosaccharide chain is successfully completed by the optimization of protecting groups and the optimization of the timing of introduction of modifying groups. The raw materials of the oligosaccharide chain prepared in the present invention are cheap and readily available, the preparation method therefor is simple and repeatable, and same has a good application prospect in the development of new drugs and vaccines for Plesimonas shigelloides, etc.

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NOVEL MUCOSAL ADJUVANTS AND DELIVERY SYSTEMS

NºPublicación: US2019231869A1 01/08/2019

Solicitante:

UNIV ARKANSAS [US]

CN_109364244_A

Resumen de: US2019231869A1

Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.

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SENSOR DEVICE FOR DETECTING TARGET MICROORGANISM IN TAP WATER IN REAL TIME

NºPublicación: US2019234947A1 01/08/2019

Solicitante:

UNIV YONSEI IACF [KR]

Resumen de: US2019234947A1

A sensor device for detecting a target microorganism in tap water in real time, the sensor device includes: a substrate; and a microorganism detection unit configured to detect the target microorganism. A microorganism mounting unit and a signal recognition unit are provided on the microorganism detection unit, and a hydrothermal synthesis unit and a signal disturbance blocking unit are provided on the signal recognition unit to detect an electrochemical reaction occurring in the microorganism mounting unit as an impedance signal value and to measure or detect the target microorganism.

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RAPID METHOD FOR DETECTION OF SALMONELLA LIVE VACCINE STRAINS

NºPublicación: EA201892078A1 31/07/2019

Solicitante:

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CN_109642247_A

Resumen de: WO2017157434A1

The present specification discloses methods of detecting a Salmonella live vaccine bacteria of interest and components useful in carrying out these methods, including a first and second pre-enrichment media, and enrichment media and a detection solution.

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Multidifferential Agar with Chromogenic Substrates

NºPublicación: US2019226005A1 25/07/2019

Solicitante:

S2M ENTPR LLC [US]

Resumen de: US2019226005A1

Multidifferential agar for differentially detecting Bile-Tolerant Gram-Negative organisms, E. coli, Salmonella, and non-E. coli coliforms and methods for using the same are disclosed. The multidifferential agar may include chromogenic substrate(s), agar, gelatin, an inhibitor of gram-positive bacteria, bacterial nutrients, propylene glycol, surfactants, and/or bile salts.

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CELL-BASED NEOANTIGEN VACCINES AND USES THEREOF

NºPublicación: US2019224236A1 25/07/2019

Solicitante:

HUTCHINSON FRED CANCER RES [US]

JP_2019514393_A

Resumen de: US2019224236A1

The present disclosure relates to immune cells that express an exogenous neoantigen and an immunogenicity enhancer, or to T cells that express an exogenous neoantigen, and their use in treating a disease or disorder, such as cancer for tumor associated neoantigens. Related expression constructs, kits, host cells, pharmaceutical compositions, and methods are also provided.

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BACILLUS SUBTILIS FOR ANIMAL FEED

NºPublicación: WO2019141815A1 25/07/2019

Solicitante:

CHR HANSEN AS [DK]

Resumen de: WO2019141815A1

The present invention provides a Bacillus subtilis strain deposited as DSM 32685 and mutant strains thereof which are susceptible to relevant antibiotics, have inhibitory activity against Staphylococcus, Streptococcus, E. coli and Salmonella enterica and have the ability to facilitate degradation of non-starch polysaccharides and thereby increase the amount of available oligosaccharides (sugar) in animal feed. The invention further relates to a composition comprising at least one Bacillus subtilis strain of the invention and optionally further bacteria, and/or one or more types of yeast. The composition may be a probiotic, Direct Fed Microbial (DFM), a premix, an animal feed additive, or an animal feed such as complete feed, e.g. a canine complete feed. The composition can be used in the prevention, reduction or control of a bacterial colonization or infection or for increasing digestibility of an animal feed, in particular a feed for a monogastric animal, such as feed for a companion animal, e.g. a domestic dog or cat.

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Automated priming and library loading device

NºPublicación: AU2018353924A1 18/07/2019

Solicitante:

CLEAR LABS INC

WO_2019133756_A1

Resumen de: AU2018353924A1

Provided herein are methods and apparatus for the identification of pathogenic and non pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food bome pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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METHODS AND SYSTEMS FOR THE RAPID DETECTION OF SALMONELLA USING INFECTIOUS AGENTS

NºPublicación: WO2019140409A1 18/07/2019

Solicitante:

LABORATORY CORP AMERICA HOLDINGS [US]

US_2019218589_A1

Resumen de: WO2019140409A1

Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Salmonella-specific bacteriophage, allows detection of a specific microorganism, such as Salmonella spp. and an indicator signal may be amplified to optimize assay sensitivity.

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Methods and Systems for the Rapid Detection of Salmonella Using Infectious Agents

NºPublicación: US2019218589A1 18/07/2019

Solicitante:

LABORATORY CORP AMERICA HOLDINGS [US]

US_2019218590_A1

Resumen de: US2019218589A1

Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Salmonella-specific bacteriophage, allows detection of a specific microorganism, such as Salmonella spp. and an indicator signal may be amplified to optimize assay sensitivity.

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Low-Buffer Nutritional Compositions And Uses Thereof

NºPublicación: US2019216122A1 18/07/2019

Solicitante:

MEAD JOHNSON NUTRITION CO [US]

CN_109259225_A

Resumen de: US2019216122A1

The present disclosure is directed to methods for supporting resistance to bacterial growth in the gastrointestinal tract of a subject, particularly in that of a human infant. In certain embodiments, the method comprises administering to a subject a nutritional composition that has a low buffer strength, wherein administration of said nutritional composition decreases the bacterial counts of bacteria selected from the group consisting of Enteropathogenic E. coli (EPEC), Enteroaggregative E. coli (EAEC), Cronobacter sakazakii, Salmonella enterica, and combinations thereof in the subject's gastrointestinal tract. This disclosure further relates to the manufacture and use of low-buffer nutritional compositions in methods for modulating gastric acidity and/or in methods for enhancing the rate of gastric emptying in a subject, each method comprising a step of administering at least one of said low-buffer nutritional compositions to the subject.

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Detection methods of Salmonella using real-time PCR kit

NºPublicación: KR20190084533A 17/07/2019

Solicitante:

KIM YUL MIN [KR]

Resumen de: KR20190084533A

본 발명은 대표적인 식중독 균인 살모넬라균의 존재 유무를 리얼타임 PCR을 이용하여 검출하는 방법에 관련된 것으로써, 높은 민감도와 특이도를 보유하고 신속하고 정확하게 살모넬라균의 존재 유무를 확인 할 수 있다.

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BACTERIAL MINICELLS FOR DELIVERING NUCLEIC ACID ADJUVANTS AND METHODS OF USING THE SAME

NºPublicación: CN110022905A 16/07/2019

Solicitante:

\u5B89\u5409\u5C3C\u79D1\u5206\u5B50\u4F20\u8F93\u516C\u53F8

AU_2017339841_A1

Resumen de: US2018100159A1

This disclosure provides intact bacterially derived minicells containing nucleic acids adjuvants or plasmids encoding nucleic acids adjuvants that can produce a desired immune response in target cells. This disclosure further provides methods that employ minicells to deliver nucleic acids adjuvants for use in the treatment of diseases, including neoplastic disease and cancer.

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MASS SPECTROMETRIC METHODS AND KITS TO IDENTIFY A MICROORGANISM

NºPublicación: US2019212338A1 11/07/2019

Solicitante:

THERMO FISHER SCIENTIFIC OY [FI]

CN_109937363_A

Resumen de: US2019212338A1

The present invention includes a novel method and system for identification of microorganisms in samples that proteins and other biological material from non-microorganism sources (e.g., proteins of mammalian origin) that can interfere with identification of the microorganisms. The methods and systems described herein include use of a single-use chromatography medium to purify intact proteins prior to mass spectrometry analysis. The chromatography medium and the methods described herein can rapidly and efficiently remove of a substantial portion of interfering biological material (e.g., mammalian proteins) from a crude cell lysate while preserving high signal strength and removing enough of the interfering protein(s) to allow for identification of the microorganism(s) by mass spectrometry analysis.

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SE131 Novel Salmonella specific bacteriophage SE131 and antibacterial composition comprising the same

NºPublicación: KR20190079850A 08/07/2019

Solicitante:

OPTIPHARM CO LTD [KR]

Resumen de: KR20190079850A

본 발명은 살모넬라균, 특히 살모넬라 엔테리티디스(Enteritidis) 및 살모넬라 갈리나룸(Gallinarum)에 특이적인 사멸능을 갖는 신규 박테리오파지 SE131, 상기 박테리오파지를 포함하는 살모넬라균에 의한 감염성 질병의 예방 또는 치료용 약학적 조성물, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 및 상기 박테리오파지를 개체에 투여하는 단계를 포함하는 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법에 관한 것이다. 본 발명의 박테리오파지 SE131을 이용한 살모넬라균에 의한 감염성 질병의 예방 또는 치료 방법은 기존의 항생제 등의 화학물질에 비해 살모넬라균, 특히 살모넬라 엔테리티디스(Enteritidis)에 대한 특이성이 매우 높고, 상기 박테리오파지 SE131은 살모넬라균에 감염하여 탁월한 용균 활성을 나타내고 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 SE131은 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제의 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는 장점이 있다. 따라서, 본 발명의 박테리오파지 SE131은 살모넬라균에 의한 감염성 질병의 예방 또는 치료, 항�

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SG102 Novel Salmonella specific bacteriophage SG102 and antibacterial composition comprising the same

NºPublicación: KR20190078864A 05/07/2019

Solicitante:

OPTIPHARM CO LTD [KR]

Resumen de: KR20190078864A

본 발명은 신규한 살모넬라균 특이 박테리오파지 SG102에 관한 것으로서, 더욱 상세하기는 상기 살모넬라균 특이 박테리오파지 SG102를 포함하는 항균 조성물에 관한 것이다. 본 발명에 따른 박테리오파지 SG102는 살모넬라균에 대한 특이성이 매우 높고, 살모넬라균에 감염하여 살모넬라균 내에서 증식함으로써 용균 활성이 우수하며, 물리화학적 자극에 강하다는 장점을 가지고 있다. 또한 본 발명의 박테리오파지 SG102는 사람, 동물, 식물 등 세균 외의 다른 숙주에는 감염되지 않으므로, 항생제의 오남용으로 인한 항생제 내성균의 문제점, 식품 내의 항생제 잔류 문제, 광범위한 숙주범위의 문제점을 해결할 수 있는바, 항생용 조성물, 사료 첨가용 조성물, 사료, 소독제 또는 세척제 분야에서 다양하게 활용될 수 있다.

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AUTOMATED PRIMING AND LIBRARY LOADING DEVICE

NºPublicación: WO2019133756A1 04/07/2019

Solicitante:

CLEAR LABS INC [US]

AU_2018353924_A1

Resumen de: WO2019133756A1

Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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DETECTION OF MICROORGANISMS IN FOOD SAMPLES AND FOOD PROCESSING FACILITIES

Nº publicación: US2019203267A1 04/07/2019

Solicitante:

CLEAR LABS INC [US]

US_2019204317_A1

Resumen de: US2019203267A1

Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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