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Resultados 66 resultados LastUpdate Última actualización 11/07/2020 [18:27:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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COMPOSITIONS AND METHODS OF TREATING CANCER AND INFECTIONS USING BACTERIOPHAGE AND ITS MUTANTS

NºPublicación: EP3675902A1 08/07/2020

Solicitante:

UNIV MICHIGAN STATE [US]

CN_111278457_A

Resumen de: WO2019045791A1

Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.

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SYSTEMS AND METHODS FOR DETECTING INFECTIOUS DISEASES

NºPublicación: CN111378568A 07/07/2020

Solicitante:

赛拉诺斯知识产权有限责任公司

US_2020013488_A1

Resumen de: US2015072338A1

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.

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SELECTIVE ENRICHMENT MEDIA AND USES THEREOF

NºPublicación: US2020208099A1 02/07/2020

Solicitante:

PARADIGM DIAGNOSTICS INC [US]

Resumen de: US2020208099A1

Selective enrichment media and methods for selectively growing and detecting Salmonella spp. and/or Shiga toxin-producing E. coli. The media may comprise a carbon and nitrogen source, an inorganic salt, a fermentable sugar, one or more selective agents, and an efflux pump inhibitor. Various selective agents include sulfa drugs, surfactants, aminocoumarins, cycloheximide, supravital stains, ascorbic acid, bromobenzoic acid, myricetin, nitrofurantoin, rifamycins, polyketides, and oxazolidinones. Various efflux pump inhibitors include arylpiperazines, such as 1-(1-naphthylmethyl)piperazine, and quinoline derivatives, such as 4-chloroquinoline. Methods of selectively growing and detecting Salmonella and/or Shiga toxin-producing E. coli are provided.

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FAST AND PORTABLE MICROFLUIDIC DETECTION SYSTEM AS AN ALTERNATIVE TO SALMONELLA'S CLASSICAL CULTURE METHOD

NºPublicación: WO2020136595A1 02/07/2020

Solicitante:

TUBITAK [TR]

TR_201820388_A2

Resumen de: WO2020136595A1

Every year, approximately 94 million cases of Salmonella gastroenteritis, with 155000 deaths, are reported each year and 85% of them reported to be food-borne. Investigation of the foods whether they are clean for Salmonella and sensitivity, easy applicability, absence of false positivity and negativity and the speed are the features sought in the analysis method for this investigation. It is not desirable for analysis to detect the presence of dead bacteria in food. Although the final product does not contain microbiologically harmful live bacteria during the food process, the detection of dead bacteria transmitted before the process causes the food product to be unfairly diagnosed as harmful. To prevent this situation, the analysis kits depending on molecular methods, increase their microorganism detection levels up to to 104 while reducing their sensitivity. Since the molecular methods cannot discriminate dead and live organisms, a confirmation test is required to prove that the positive result of the analysis belongs to the live bacteria in the food, which results in additional cost and time loss. In the same way, it is necessary to verify whether the colonies that grow in the gold standard culture method, belong to Salmonella bacteria. In the developed system; 105 dead bacterial DNA is eliminated in the food to prevent false positive results and the minimum detection limit is 10 bacteria. Also, in developed system, 4 primers specific to 6 regions of DNA are used. Therefo

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COMPOSITIONS AND METHODS FOR RAPID DETECTION OF SALMONELLA SEROVAR D1

NºPublicación: US2020208199A1 02/07/2020

Solicitante:

ENVIROLGIX INC [US]
ENVIROLOGIX INC [US]

JP_2018523474_A

Resumen de: US2020208199A1

The present invention features rapid and accurate methods for detecting Salmonella (e.g., in a food product, environmental sample, biological sample or other material).

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SYSTEMS AND METHODS FOR DETECTING INFECTIOUS DISEASES

NºPublicación: EP3674422A2 01/07/2020

Solicitante:

THERANOS IP COMPANY LLC [US]

US_2020013488_A1

Resumen de: EP3674422A2

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.

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A METHOD OF REDUCING EGG CONTAMINATION

NºPublicación: RU2018145441A 26/06/2020

Solicitante:

УНИВЕРСИТЕЙТГЕНТ

PE_20190225_A1

Resumen de: WO2017202804A1

The present invention relates to Salmonella mutant strains and their use as a vaccine for preventing Salmonella infection, in particular in eggs.

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DEVICE FOR RAPID DETECTION OF SALMONELLA BACTERIA, METHOD OF FABRICATING AND OPERATING THEREOF

NºPublicación: WO2020130791A1 25/06/2020

Solicitante:

UNIV OF MALAYA [MY]

Resumen de: WO2020130791A1

The present invention relates to a device for rapid detection of Salmonella bacteria, a method of fabricating and a method of operating thereof. The biosensor device is an aptasensor comprising a thiolated DNA aptamer, wherein the thiolated DNA aptamer is deployed onto an electrode having an active electrode area formed by a predefined photolitographic process via a carbon nanotube drop-casted thereon. The biosensor has a low detection limit of analyte and has the ability to measure a wide range of analyte concentrations.

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Surface display of antigens on Gram-negative outer membrane vesicles

NºPublicación: US2020197308A1 25/06/2020

Solicitante:

DE STAAT DER NEDERLANDEN VERT DOOR DE MINI VAN VWS MINI VAN VOLKSGEZONDHEID WELZIJN EN [NL]
DE STAAT DER NERDERLANDEN VERT DOOR DE MINI VAN VWS MINI VAN VOLKSGERZONDHEID WELZIJN [NL]

JP_2018521632_A

Resumen de: US2020197308A1

The present invention relates to vaccine compositions based on Gram-negative outer membrane vesicles displaying antigens of pathogens expressed as part of a fusion protein comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria, and use of such compositions in vaccination. The invention further relates to the fusion lipoproteins comprising N-terminal parts of surface expressed lipoproteins of Gram-negative bacteria and antigens of pathogens fused thereto, DNA constructs and bacterial host cells for expressing these fusion lipoproteins and to methods for producing outer membrane vesicles displaying the fusion lipoproteins.

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Methods and systems for the rapid detection of Salmonella using infectious agents

NºPublicación: AU2019208101A1 18/06/2020

Solicitante:

LABORATORY CORP AMERICA HOLDINGS

AU_2019208099_A1

Resumen de: AU2019208101A1

Disclosed herein are methods and systems for rapid detection of microorganisms in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as

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METHODS FOR GENERATING EPITOPES FOR BINDING TO RECOGNITION MOLECULES BY TEMPLATED ASSEMBLY

NºPublicación: EP3665277A1 17/06/2020

Solicitante:

TRIBIOTICA LLC [US]

CN_111133104_A

Resumen de: WO2019032942A1

The present disclosure provides polypeptides and polypeptide-nucleic acid conjugates comprising portions of epitopes, and methods of using target molecule binding components, such as aptamers, to present template sequences, where the target molecule binding components bind to target molecules unique to specific cellular targets, for the purpose of templated assembly of the epitopes for recognition molecules.

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COMPOSITIONS AND METHODS FOR INHIBITING PATHOGEN INFECTION

NºPublicación: EP3666285A2 17/06/2020

Solicitante:

UNIV NORTH CAROLINA CHAPEL HILL [US]
UNIV JOHNS HOPKINS [US]

US_2015284451_A1

Resumen de: EP3666285A2

The presently-disclosed subject matter relates to antibodies, compositions, and methods for inhibiting and treating pathogen infection and providing contraception. In particular, the presently-disclosed subject matter relates to inhibiting and treating pathogen infection and providing contraception in a subject using compositions and antibodies capable of trapping pathogens or sperm in mucus, thereby inhibiting transport of pathogens or sperm across mucus secretions. The subject matter further relates to methods for monitoring the effectiveness of vaccines by detecting antibodies capable of trapping pathogens in mucus.

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MULTI-FUNCTIONALIZED nOMV CONJUGATES

NºPublicación: EP3664837A1 17/06/2020

Solicitante:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

WO_2019030271_A1

Resumen de: WO2019030271A1

The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.

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Polysaccharide Purification for Vaccine Production using Lytic Enzymes, Tangential Flow Filtration, and Multimode Chromatography

NºPublicación: CN111295450A 16/06/2020

Solicitante:

创赏有限公司

KR_20200024896_A

Resumen de: US2019010187A1

An improved, cost effective and shortened process of purification of the capsular polysaccharide of S. Pneumoniae, Group B Streptococcus, H. Influenzae, S. Typhoid and N. meningitidis is disclosed. The process includes a cocktail of enzyme treatment, tangential flow filtration, and multimodal chromatography purification. For Gram-negative bacteria, endotoxin removal process involves endotrap HD resin. This shortened process achieved the purity required by WHO/EP/BP for the use in human vaccine preparation, with simple steps and higher yield as compared to conventional processes. The steps of the process avoid use of organic solvents such as, for example, alcohol, phenol, and ultracentrifugation that are otherwise expensive and time consuming to perform, and/or health hazards for commercial use. This process disclosed is also simple, efficient, non-toxic, easy to scale-up, and environmentally friendly.

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基于杆状病毒表达系统的Flic免疫佐剂及制备方法和应用

NºPublicación: CN111285924A 16/06/2020

Solicitante:

华南农业大学

Resumen de: CN111285924A

本发明公开了一种基于杆状病毒表达系统的Flic免疫佐剂及制备方法和应用。本发明是将编码鼠伤寒沙门氏菌鞭毛蛋白的核苷酸序列通过Bac‑to‑Bac杆状病毒表达系统进行表达,纯化,得到的可溶性Flic蛋白即为Flic免疫佐剂。本发明提供的方法得到的可溶性Flic蛋白产量高,而且有极高的理化特性、生物学活性、免疫原性和安全性。用该Flic免疫佐剂制备得到的灭活禽流感疫苗,免疫后可快速产生高滴度的HI抗体效价,同时可以诱导产生细胞免疫反应,具有良好的免疫原性和反应性。

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COMPOSITIONS AND METHODS OF TREATING CANCER AND INFECTIONS USING BACTERIOPHAGE AND ITS MUTANTS

NºPublicación: CN111278457A 12/06/2020

Solicitante:

密西根州立大学校董会

WO_2019045791_A1

Resumen de: WO2019045791A1

Provided herein are vaccine composition comprising an antigen conjugated to a capsid, wherein the capsid comprises wild type or native sequence. Provided herein are also vaccine composition comprising an antigen conjugated to a capsid, wherein said capsid comprises at least one mutation, such as a non-natural mutation. Such compositions are useful in the treatment and prevention of pathogenic infections, inflammatory diseases, and neurodegenerative disease, and cancer, among others.

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LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS HETEROLOGOUS OUTER MEMBRANE PROTEIN ANTIGENS AND METHODS OF USE THEREOF

NºPublicación: US2020179501A1 11/06/2020

Solicitante:

UNIV MARYLAND [US]
NAT RES COUNCIL CANADA [CA]

CA_3063419_A1

Resumen de: US2020179501A1

The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector comprising a heterologous antigen from a pathogen, wherein the heterologous antigen comprises an outer membrane protein, an antigenic fragment thereof or a variant thereof, wherein the antigen is delivered to a mucosal tissue of the subject by an outer membrane vesicle.

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LUCIFERASE-BASED THERMAL SHIFT ASSAYS

NºPublicación: US2020174012A1 04/06/2020

Solicitante:

PROMEGA CORP [US]

US_2016282360_A1

Resumen de: US2020174012A1

Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).

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SAMPLING SYSTEMS AND RELATED MATERIALS AND METHODS

NºPublicación: US2020170627A1 04/06/2020

Solicitante:

PROGENITY INC [US]

JP_2019528117_A

Resumen de: US2020170627A1

Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are disclosed.

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BACTERIA-BASED PROTEIN DELIVEY

NºPublicación: EP3660034A1 03/06/2020

Solicitante:

UNIV BASEL [CH]

ES_2754508_T3

Resumen de: EP3660034A1

The present invention relates to recombinant Gram-negative bacterial strains and the use thereof for delivery of heterologous proteins into eukaryotic cells.

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HokC Singleplex Real-Time PCR Development of a Singleplex Real-Time PCR Kit for Rapid Detection of Salmonella Enteritidis HokC target gene

NºPublicación: KR20200059758A 29/05/2020

Solicitante:

UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV [KR]
KOREA FOOD & DRUG ADMIN [KR]

Resumen de: KR20200059758A

본 발명은 살모넬라 엔테리티디스() 균주의 검출용 프라이머 세트, 프로브, 이를 포함하는 살모넬라 엔테리티디스 균주의 검출용 조성물, 키트 및 검출 방법에 관한 것이다. 본 발명의 프라이머 세트 및 프로브를 이용하여 conventional PCR 또는 Real-Time PCR을 수행 시, HokC 유전자를 특이적으로 타겟하여 살모넬라 엔테리티디스만을 특이적으로 검출하는 특이도, 극소량의 시료 농도에서도 검출되는 민감도가 매우 우수함을 확인하여 살모넬라 엔테리티디스의 검출을 위한 양성대조군 DNA로서도 이용 가능한 효과가 있어, 관련 산업에 유용하게 이용될 수 있다.

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METHODS AND MATERIALS FOR DETECTING SALMONELLA IN BEEF

NºPublicación: WO2020106897A1 28/05/2020

Solicitante:

BRANDT ALEX [US]
GARRETT RANDAL [US]
PLEITNER AARON [US]
MURAOKA WAYNE MURAOKA [US]
HOLZER KATLYN [US]

Resumen de: WO2020106897A1

Materials and methods for detecting Salmonella in beef are provided herein.

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DE-IMMUNIZED SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES FOR APPLICATIONS IN MAMMALS

NºPublicación: JP2020079267A 28/05/2020

Solicitante:

モレキュラーテンプレーツ,インク.MOLECULARTEMPLATES,INC.

JP_2020073569_A

Resumen de: CA2937407A1

The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins. The Shiga toxin effector polypeptides of the present invention have uses as components of therapeutics, diagnostics, and immunization materials. The cytotoxic proteins of the present invention have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections. The proteins of the present invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring the treatment of a variety of diseases, such as, e.g., cancers, immune disorders, and microbial infections.

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NANOPORE-MATCHED PROTEIN SHUTTLE FOR MOLECULAR CHARACTERIZATION

NºPublicación: EP3655423A1 27/05/2020

Solicitante:

HARVARD COLLEGE [US]
UNIV MASSACHUSETTS [US]

CN_110914291_A

Resumen de: WO2019018398A1

Systems and methods are provided for trapping and electrically monitoring molecules in a nanopore sensor. The nanopore sensor comprises a support structure with a first and a second fluidic chamber, at least one nanopore fluidically connected to the two chambers, and a protein shuttle. The protein shuttle comprises an electrically charged protein molecule, such as Avidin. The nanopore can be a Clytosolin A. A method can comprise applying a voltage across the nanopores to draw protein shuttles towards the nanopores. The ionic current through each or all of the nanopores can be concurrently measured. Based on the measured ionic current, blockage events can be detected. Each blockage event indicates a capture of a protein shuttle by at least one nanopore. Each blockage event can be detected through a change of the total ionic current flow or a change in the ionic current flow for a particular nanopore.

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A FOOD SAFETY VACCINE TO CONTROL SALMONELLA ENTERICA AND REDUCE CAMPYLOBACTER IN POULTRY

Nº publicación: BR112019015425A2 26/05/2020

Solicitante:

UNIV FLORIDA [US]

US_2020009240_A1

Resumen de: WO2018140717A1

Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.

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