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Resultados 51 resultados LastUpdate Última actualización 25/01/2023 [13:51:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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ENGINEERED S. TYPHIMURIUM AND USES THEREOF

NºPublicación: WO2023287770A2 19/01/2023

Solicitante:

VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIV [US]

Resumen de: WO2023287770A2

Described herein are engineered Salmonella Typhimurium (S. Typhimurium) bacteria and uses thereof. In some embodiments, the engineered S. Typhimurium bacteria comprises an exogenous collagenase. Also described in exemplary embodiments herein methods of using the engineered S. Typhimurium bacteria, such as part of a cancer therapy.

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Sensing Chip with Fluidic Device

NºPublicación: AU2022204265A1 19/01/2023

Solicitante:

KAO HSI TENG [TW]

CN_115508426_PA

Resumen de: AU2022204265A1

A sensing chip with fluidic device includes a substrate with a first area and a second area, a field effect transistor is arranged in the second area of the substrate and is electrically connected with the field effect transistor. The fluidic device includes an insulation layer with a window to expose the surface of substrate in the second area. A second gate electrode is arranged in the window of the isolation layer on the second area of the substrate. The sample is placed in the fluidic device to contact with the second gate electrode, and the receptor(s) on the metal layer will capture the target object in the sample, so the voltage of the metal layer will change with amount of the target object captured by the receptor(s). Thus, the concentration of the target object(s) in the sample may obtain by the changes of the voltage of the metal layer. 3 0 50 4010 206 m-40214 lOB 1OA Fig.lIA

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DETOXIFIED LIPOPOLYSACCHARIDES (LPS), NATURALLY NON-TOXIC LPS, AND USES THEREOF

NºPublicación: EP4117790A1 18/01/2023

Solicitante:

HEPHAISTOS PHARMA [FR]

CA_3171408_A1

Resumen de: WO2021180972A1

The invention relates to an enriched population of modified lipopolysaccharide (LPS) molecular species being: - devoid of phosphate group at position C1 of the reducing end of their lipid A domain; and - substituted at position C6' of the non-reducing end of their lipid A domain by a hydrophilic moiety, with the proviso that said hydrophilic moiety is not a hydroxyl group. It also relates to compositions comprising the enriched population of modified LPS; and uses of naturally-occurring LPS molecular species and/or enriched population of modified LPS molecular species for treating and/or preventing cancer, inflammatory diseases or infectious diseases, and for stimulating an immune response or vaccinating a subject.

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LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS CANCER PROTEIN ANTIGENS AND METHODS OF USE THEREOF

NºPublicación: EP4114918A1 11/01/2023

Solicitante:

UNIV MARYLAND [US]
IRAZU BIO LLC [US]

AU_2021230602_PA

Resumen de: WO2021178888A1

The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector, wherein the Salmonella Typhi vector has been engineered to express one or more cancer antigens. In some aspects the vector has been engineered to express an outer membrane folding protein Bam A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella Typhi vector is capable of delivering the antigen to a mucosal tissue or subcutaneously to dendritic cells via an outer membrane vesicle when administered to a subject.

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SYSTEMS FOR OBTAINING SAMPLES USING INGESTIBLE DEVICES

NºPublicación: JP2023002585A 10/01/2023

Solicitante:

ビオラ・セラピューティクス・インコーポレイテッド

US_2020170627_A1

Resumen de: WO2018035394A1

Ingestible devices configured to obtain samples when present in the GI tract of a subject, as well as related systems and methods, are disclosed. Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are also disclosed.

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Reduction of viral disease transmission by avian antibodies

NºPublicación: AU2021267035A1 05/01/2023

Solicitante:

CAMAS INCORPORATED

WO_2021226358_A1

Resumen de: AU2021267035A1

Formulations of egg powders with avian antibodies that act as mucosal protectants are provided. The formulations are effective for protecting the mucosal membranes in the pharyngeal area of an individual from viral infections. Formulations effective for reducing infections of SARS-CoV-2 in individuals are provided. Formulations are also effective for reducing transmission of viral disease. The formulations are tablets, candies, gummies, throat lozenges, and powders for administering to the pharyngeal area. Methods for administering the formulations for reducing viral disease such as Covid-19 are disclosed.

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ANTIBACTERIAL FORMULATION MADE OF A MIXTURE OF BACTERIOPHAGES, USE THEREOF, AND METHOD FOR PREVENTING OR TREATING DISEASES CAUSED BY SALMONELLA SPP. IN BREEDING ANIMALS, BY ORALLY ADMINISTERING THE FORMULATION

NºPublicación: EP4111865A1 04/01/2023

Solicitante:

PHAGELAB CHILE SPA [CL]

WO_2022241579_PA

Resumen de: WO2022241579A1

The invention relates to an antibacterial formulation comprising a mixture of bacteriophages that have lytic activity against Salmonella spp. strains, and a carrier, pH stabiliser and/or pharmaceutically and veterinarily acceptable excipients. This formulation is useful for the prevention and treatment of infectious diseases caused by Salmonella spp. and different serovars. The invention also relates to a use and method for preventing or treating infectious diseases caused by Salmonella spp. in breeding animals which comprises orally administering the antibacterial formulation to a non-human animal.

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YjeK YjeK gene deleted Salmonella typhimurium strain and Salmonella vaccine composition comprising the same

NºPublicación: KR20220170779A 30/12/2022

Solicitante:

INNOVAC [KR]

WO_2022270953_PA

Resumen de: WO2022270953A1

The present invention relates to a Salmonella typhimurium strain having YjeK gene deleted therefrom and to uses thereof. More specifically, the present invention relates to: a novel Salmonella typhimurium strain; and a vaccine composition, an immunogenic composition, and a feed composition comprising same. It was confirmed that the Salmonella typhimurium strain having YjeK gene deleted therefrom according to the present invention can effectively prevent Salmonella infection, thereby remarkably increasing a survival rate of an individual. This means that when the Salmonella typhimurium strain having YjeK gene deleted therefrom of the present invention is used as a vaccine, diseases related to Salmonella infection can be effectively prevented such that the present invention can be used in various ways in the field of livestock disease control.

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ATTENUATED SALMONELLA, VACCINES, AND DELIVERY PLATFORM

NºPublicación: WO2022271976A1 29/12/2022

Solicitante:

ELANCO US INC [US]

Resumen de: WO2022271976A1

The present invention provides an intracellular delivery platform comprising an attenuated bacterium carrying a self-amplifying nucleic acid encoding a therapeutic biomolecule. The therapeutic biomolecule has a desired activity or effect such as treating or preventing an infection, disease or disorder, or eliciting protective immunity against a pathogenic or parasitic organism. Genetically modified and attenuated bacteria, particularly Salmonella bacteria, are provided. Methods for intracellular and systemic delivery of one or more therapeutic biomolecule are provided. Self-amplifying nucleic acids are provided.

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SALMONELLA TYPHIMURIUM STRAIN HAVING YJEK GENE DELETED THEREFROM AND SALMONELLA VACCINE COMPOSITION COMPRISING SAME

NºPublicación: WO2022270953A1 29/12/2022

Solicitante:

INNOVAC CO [KR]

KR_20220170779_PA

Resumen de: WO2022270953A1

The present invention relates to a Salmonella typhimurium strain having YjeK gene deleted therefrom and to uses thereof. More specifically, the present invention relates to: a novel Salmonella typhimurium strain; and a vaccine composition, an immunogenic composition, and a feed composition comprising same. It was confirmed that the Salmonella typhimurium strain having YjeK gene deleted therefrom according to the present invention can effectively prevent Salmonella infection, thereby remarkably increasing a survival rate of an individual. This means that when the Salmonella typhimurium strain having YjeK gene deleted therefrom of the present invention is used as a vaccine, diseases related to Salmonella infection can be effectively prevented such that the present invention can be used in various ways in the field of livestock disease control.

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GROUP A STREP IMMUNOGENIC COMPOSITIONS WITH POLYSACCHARIDE-PROTEIN CONJUGATES

NºPublicación: EP4106807A1 28/12/2022

Solicitante:

VAXCYTE INC [US]

KR_20220143107_PA

Resumen de: WO2021167996A1

The present disclosure provides immunogenic compositions comprising Group A Streptococcus (GAS) polypeptide antigens and at least one polypeptide-polysaccharide conjugate. The present disclosure further provides methods of using such compositions to induce immune responses against GAS infections in subjects.

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SENSING CHIP WITH FLUIDIC DEVICE

NºPublicación: EP4109086A1 28/12/2022

Solicitante:

KAO HSI TENG [TW]

AU_2022204265_A1

Resumen de: EP4109086A1

A sensing chip with fluidic device (1) includes a substrate (10) with a first area (10A) and a second area (10B), a second gate electrode (40) is arranged in the second area of the substrate and is electrically connected with the field effect transistor (20). The fluidic device includes an insulation layer (30) with a window (302) to expose the surface of substrate in the second area. A second gate electrode is arranged in the window of the isolation layer on the second area of the substrate. The sample is placed in the fluidic device to contact with the second gate electrode, and the receptor(s) on the metal layer will capture the target object in the sample, so the voltage of the metal layer will change with amount of the target object captured by the receptor(s). Thus, the concentration of the target object(s) in the sample may obtain by the changes of the voltage of the metal layer.

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SENSING CHIP WITH FLUIDIC DEVICE

NºPublicación: CN115508426A 23/12/2022

Solicitante:

高熹腾

AU_2022204265_A1

Resumen de: EP4109086A1

A sensing chip with fluidic device (1) includes a substrate (10) with a first area (10A) and a second area (10B), a second gate electrode (40) is arranged in the second area of the substrate and is electrically connected with the field effect transistor (20). The fluidic device includes an insulation layer (30) with a window (302) to expose the surface of substrate in the second area. A second gate electrode is arranged in the window of the isolation layer on the second area of the substrate. The sample is placed in the fluidic device to contact with the second gate electrode, and the receptor(s) on the metal layer will capture the target object in the sample, so the voltage of the metal layer will change with amount of the target object captured by the receptor(s). Thus, the concentration of the target object(s) in the sample may obtain by the changes of the voltage of the metal layer.

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SENSING CHIP WITH FLUIDIC DEVICE

NºPublicación: US2022404345A1 22/12/2022

Solicitante:

KAO HSI TENG [TW]

AU_2022204265_A1

Resumen de: US2022404345A1

A sensing chip with fluidic device includes a substrate with a first area and a second area, a field effect transistor is arranged in the second area of the substrate and is electrically connected with the field effect transistor. The fluidic device includes an insulation layer with a window to expose the surface of substrate in the second area. A second gate electrode is arranged in the window of the isolation layer on the second area of the substrate. The sample is placed in the fluidic device to contact with the second gate electrode, and the receptor(s) on the metal layer will capture the target object in the sample, so the voltage of the metal layer will change with amount of the target object captured by the receptor(s). Thus, the concentration of the target object(s) in the sample may obtain by the changes of the voltage of the metal layer.

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SENSING CHIP WITH FLUIDIC DEVICE

NºPublicación: CA3164766A1 22/12/2022

Solicitante:

KAO HSI TENG [TW]

AU_2022204265_A1

Resumen de: CA3164766A1

A sensing chip with fluidic device includes a substrate with a first area and a second area, a field effect transistor is arranged in the second area of the substrate and is electrically connected with the field effect transistor. The fluidic device includes an insulation layer with a window to expose the surface of substrate in the second area. A second gate electrode is arranged in the window of the isolation layer on the second area of the substrate. The sample is placed in the fluidic device to contact with the second gate electrode, and the receptor(s) on the metal layer will capture the target object in the sample, so the voltage of the metal layer will change with amount of the target object captured by the receptor(s). Thus, the concentration of the target object(s) in the sample may obtain by the changes of the voltage of the metal layer.

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FliC-FimA-CD40L Vaccine composition for preventing or treating fowl typhoid and salmonellosis simultaneously comprising Salmonella gallinarum mutant expressing FliC-FimA-CD40L fusion antigen as effective component

NºPublicación: KR20220167577A 21/12/2022

Solicitante:

INDUSTRIAL COOPERATION FOUNDATION JEONBUK NATIONAL UNIV [KR]

Resumen de: KR20220167577A

본 발명의 FliC-FimA-CD40L 융합 항원을 발현하는 살모넬라 갈리나룸 변이주를 이용한 백신 조성물은 가금티푸스 및 살모넬라증의 동시 방어가 가능하고 야생형 살모넬라균의 제거에 충분한 면역원성을 제공하며, 균주 배양 방법으로 경제적이고 간편하게 백신을 제조할 수 있어, 가금티푸스 및 살모넬라증 동시 예방 또는 치료용 백신 조성물로 유용하게 사용될 것으로 기대된다.

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Minimum culture medium composition for detection of Salmonella Typhimurium

NºPublicación: KR20220167043A 20/12/2022

Solicitante:

UNIV KOOKMIN IND ACAD COOP FOUND [KR]
PNGBIOMED CO LTD [KR]

Resumen de: KR20220167043A

본 발명은 식품 내 미생물을 신속하게 검출할 수 있는 살모넬라 티피뮤리움(Salmonella Typhimurium) 검출용 최소배양 배지 조성물에 관한 것으로, 고가의 장비 없이 간편하고 쉽게 식품 속 미생물을 검출하는 방법을 제공하기 위해 살모넬라 티피뮤리움(Salmonella Typhimurium)을 BHI(Brain heart infusion) 배지; 피루브산 나트륨(Sodium pyruvate); 프롤린(Proline); 및 황산 마그네슘(Magnesium sulfate)을 포함하는 살모넬라 티피뮤리움(Salmonella Typhimurium) 검출용 배지 조성물에 배양할 경우, 단시간 배양하여도 유도기에 빠르게 도달하는 것을 확인하고, PCR에도 미생물의 DNA가 높은 농도라 검출되는 것을 확인함으로써, 상기 배지 조성물을 식품 속 미생물을 신속하게 검출할 수 잇는 최소 배양 배지로 제공된다.

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MOLECULAR TOOL

NºPublicación: MY194838A 19/12/2022

Solicitante:

UNIV SAINS MALAYSIA [MY]

Resumen de: MY194838A

This invention is directed to mixture of primers and probes for the detection of 4 most common causes of acute febrile illnesses (Leptospirosis, Melioidosis, Salmonella bacteremia and Malaria), particularly in tropical area, with optional incorporation of an internal control. This invention is suitable to be used in any molecular platform, especially the Taqman real-time PCR. The most illustrative drawing: FIG. 1

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NOVEL VACCINE COMPOSITIONS

NºPublicación: JP2022552352A 15/12/2022

Solicitante:

グラクソスミスクラインバイオロジカルズソシエテアノニム

BR_112022006549_A2

Resumen de: EP3808372A1

A Shigella flexneri O-antigen of a first serotype or subserotype for use in raising an immune response against one or more Shigella flexneri O-antigen of a different serotype or subserotype, together with associated binding moieties, pharmaceutical compositions, kits, uses or methods.

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Structurally modified chimeric polypeptide of human papillomavirus, recombinant protein comprising same polypeptide, and use of same protein

NºPublicación: AU2021281910A1 15/12/2022

Solicitante:

GENEMATRIX INC [KR]

WO_2021241928_A1

Resumen de: AU2021281910A1

The present invention relates to a chimeric recombinant protein having a therapeutic effect on cervical cancer through the fusion of a fusion protein for increasing immunogenicity and a genetic modification of E6 and E7, which are carcinogenic proteins of high-risk human papillomavirus type 16. The HPV type 16 E6/E7 chimeric recombinant protein of the present invention that is fused with a fusion protein of flagellin showed the lowest tumor cell volume, the immune response of specific T cells according to the recombinant antigen was confirmed to be significant, and, when the preventive effect thereof was measured, the tumor cell volume was low, and increased antibody titers were confirmed. In addition, the human papillomavirus recombinant antigen of the present invention exhibits therapeutic and preventive effects on tumors and can be applied as a therapeutic/preventive vaccine composition.

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ATTENUATED SALMONELLA GALLINARUM MUTANT STRAINS AND USES THEREOF

NºPublicación: US2022395565A1 15/12/2022

Solicitante:

SEOUL NAT UNIV R&DB FOUNDATION [KR]

KR_20220159914_PA

Resumen de: US2022395565A1

The present disclosure relates to Salmonella Gallinarum mutant strains and uses thereof. A vaccine composition according to an aspect has no risk of reverting to pathogenicity, has no residual pathogenicity due to detoxification of an endotoxin, and does not cause lesions and bacterial re-isolation, thereby exhibiting significantly improved safety compared to the existing fowl typhoid vaccines. In addition, since the vaccine composition induces a high-level immune response even when administered to young chicks, it may be used regardless of age, and as the vaccine strain may be used as a live vaccine having an excellent protective capability by itself, the vaccine composition may be useful for preventing and alleviating fowl typhoid.

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Pathogenic Escherichia coli Salmonella and Shigella-specific bacteriophage and antibacterial composition comprising the same

NºPublicación: KR20220164159A 13/12/2022

Solicitante:

KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND [KR]

Resumen de: KR20220164159A

본 발명은 병원성 대장균, 살모넬라균, 시겔라균에 대해 특이적인 사멸능을 갖는 신규 박테리오파지 KFS-EC3 및 이의 조성물에 관한 것이다. 본 발명의 박테리오파지 KFS-EC3는 병원성 대장균, 살모넬라균 또는 시겔라균에 특이적 사멸능을 가지는 넓은 숙주 범위를 가지는 반면, 유익균은 사멸시키지 않고 내산성 및 내열성이 우수하므로, 병원성 대장균, 살모넬라균 및 시겔라균 중 어느 하나 이상의 균에 의한 감염성 질병의 예방 또는 치료에 활용할 수 있을 뿐만 아니라, 항생용 조성물, 사료 첨가용 조성물, 소독제, 또는 세척제 등에도 광범위하게 이용될 수 있다.

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ATTENUATED SALMONELLA GALLINARUM MUTANT STRAINS AND USES THEREOF

NºPublicación: US2022387574A1 08/12/2022

Solicitante:

SEOUL NAT UNIV R&DB FOUNDATION [KR]
GENINER CO LTD [KR]

KR_20220159914_PA

Resumen de: US2022387574A1

The present disclosure relates to Salmonella Gallinarum mutant strains and uses thereof. A vaccine composition according to an aspect has no risk of recovering pathogenicity, has no residual pathogenicity due to detoxification of an endotoxin, and does not cause lesions and bacterial re-isolation, thereby exhibiting significantly improved safety compared to the existing fowl typhoid vaccines. In addition, since the vaccine composition induces a high-level immune response even when administered to young chicks, it may be used regardless of age, and as the vaccine strain may be used as a live vaccine having an excellent protective capability by itself, the vaccine composition may be useful for preventing and alleviating fowl typhoid.

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ATTENUATED SALMONELLA GALLINARUM MUTANT STRAINS AND USES THEREOF

NºPublicación: KR20220159912A 05/12/2022

Solicitante:

SEOUL NAT UNIV R&DB FOUNDATION [KR]

KR_20220159914_PA

Resumen de: US2022387574A1

The present disclosure relates to Salmonella Gallinarum mutant strains and uses thereof. A vaccine composition according to an aspect has no risk of recovering pathogenicity, has no residual pathogenicity due to detoxification of an endotoxin, and does not cause lesions and bacterial re-isolation, thereby exhibiting significantly improved safety compared to the existing fowl typhoid vaccines. In addition, since the vaccine composition induces a high-level immune response even when administered to young chicks, it may be used regardless of age, and as the vaccine strain may be used as a live vaccine having an excellent protective capability by itself, the vaccine composition may be useful for preventing and alleviating fowl typhoid.

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ATTENUATED SALMONELLA GALLINARUM MUTANT STRAINS AND USES THEREOF

Nº publicación: KR20220159914A 05/12/2022

Solicitante:

SEOUL NAT UNIV R&DB FOUNDATION [KR]

KR_20220159913_PA

Resumen de: US2022387574A1

The present disclosure relates to Salmonella Gallinarum mutant strains and uses thereof. A vaccine composition according to an aspect has no risk of recovering pathogenicity, has no residual pathogenicity due to detoxification of an endotoxin, and does not cause lesions and bacterial re-isolation, thereby exhibiting significantly improved safety compared to the existing fowl typhoid vaccines. In addition, since the vaccine composition induces a high-level immune response even when administered to young chicks, it may be used regardless of age, and as the vaccine strain may be used as a live vaccine having an excellent protective capability by itself, the vaccine composition may be useful for preventing and alleviating fowl typhoid.

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