CORONAVIRUS: DIAGNÓSTICO Y TERAPIA EN HUMANOS

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Resultados 86 resultados LastUpdate Última actualización 11/08/2020 [20:31:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 365 días/Published applications in the last 365 days



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Colloidal gold kit for jointly detecting coronavirus IgM/IgG antibody, and preparation method thereof

NºPublicación: CN111089962A 01/05/2020

Solicitante:

ZHONGSHAN BIO TECH CO LTD

Resumen de: CN111089962A

The invention discloses a colloidal gold kit for jointly detecting coronavirus IgM/IgG antibody, and a preparation method thereof, and relates to the field of biological medicine. Whether anti-novel coronavirus nucleocapsid protein IgM antibody and/or anti-novel coronavirus nucleocapsid protein IgG antibody exists in human serum or plasma or not by adopting an antigen-antibody sandwich method anda colloidal gold immunochromatography method principle, the novel coronavirus nucleocapsid protein containing 6xHis mark is marked by applying colloidal gold, thereby forming gold-marked N protein tobe adsorbed on a gold-marked pad, the novel coronavirus nucleocapsid protein containing 6xHis mark is used as an indication marker, the mouse-anti-human u chain monoclonal antibody is coated on the IgM detection line of a NC membrane, the mouse-anti-human IgG monoclonal antibody is coated on the IgG detection line and the mouse-anti 6xHis monoclonal antibody is coated on a quality control line ofthe NC membrane, the qualitative detection of the anti-novel coronavirus nucleocapsid protein IgG antibody is realized, and the colloidal gold kit disclosed by the invention has the advantages of being convenient to use, high in sensitivity and short in detection time.

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Non-contact face close-range air supply and exhaust device capable of preventing novel coronavirus pneumonia virus propagation

NºPublicación: CN111084943A 01/05/2020

Solicitante:

CHONGQING INDUSTRY POLYTECHNIC COLLEGE

Resumen de: CN111084943A

The invention relates to a non-contact face close-range air supply and exhaust device capable of preventing novel coronavirus pneumonia virus propagation. The non-contact face close-range air supply and exhaust device comprises a head ring, a temperature sensing probe, an air guide cylinder, an upper baffle and a connector. A connecting rod is arranged at the top end of the head ring; the temperature sensing probe is arranged at the outer end of the connecting rod; a cavity is formed in the air guide cylinder, an airflow through hole is formed in the inner ring, and the airflow through hole iscommunicated with the cavity; rotating shafts are arranged inside the two ends of the air guide cylinder; the rotating shafts are rotationally connected with the head ring; a joint is arranged on oneside of the head ring, an opening is formed in the outer side of the joint, and the opening is communicated with the cavity; the upper baffle and a lower baffle are arranged in the middle section ofthe air guide cylinder; a rotating groove is formed in the connector, and the connector is rotationally connected with the joint; an air guide pipe is arranged at the lower end of the connector; airflow in the air guide pipe can enter and exit from the airflow through hole through the connector, the joint and the cavity; and the air guide cylinder can rotate along center lines A of the rotating shafts. The non-contact face close-range air supply and exhaust device can provide guarantee for public t

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Detection kit for novel coronavirus, influenza A and B and respiratory syncytial virus

NºPublicación: CN111088408A 01/05/2020

Solicitante:

GUANGZHOU HYBRIBIO PHARMACEUTICAL TECH CO LTD
GUANGDONG HYBRIBIO BIOTECH CO LTD
GUANGZHOU KAIPU MEDICAL LABORATORY CO LTD

Resumen de: CN111088408A

The invention discloses a detection kit for a novel coronavirus, influenzas A and B and a respiratory syncytial virus. According to the detection kit, through combining primer probe design and adaptive detection system optimizing research, a group of nucleic acid combined detection primer and probe combinations and nucleic acid combined detection kits for the novel coronavirus (2019-nCoV/SARS-CoV2), an influenza A virus (FluA), an influenza B virus (FluB) and the respiratory syncytial virus (RSV) are developed, and sequences of primers and probes are shown in SEQ ID NO: 1-18. The kit has theadvantages of high detection sensitivity, good repeatability and low false negative and false positive and can effectively distinguish novel coronavirus infection from ordinary viral influenza and respiratory syncytial virus induced respiratory tract infection, so that precise diagnosis and subsequent precise treatment on a sufferer are achieved.

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Kit for detecting coronavirus RNA and method for detecting coronavirus RNA

NºPublicación: CN111088407A 01/05/2020

Solicitante:

WUXI SHENRUI BIO PHARMACEUTICALS CO LTD

Resumen de: CN111088407A

The invention provides a kit for detecting coronavirus RNA and a method for detecting the coronavirus RNA. The kit for detecting the coronavirus RNA comprises the following components: nuclease Cas13a, Cas13a guide RNA used for specifically detecting SARS-CoV-1 gene sequence and SARS-CoV-2 gene sequence, a RNA fluorescence probe, reverse transcriptase, DNA polymerase, T7RNA polymerase, and a buffer. The kit for detecting the coronavirus RNA and the method for detecting the coronavirus RNA disclosed by the invention are capable of realizing specific detection on coronaviruses with the SARS-CoV-1 gene sequence and the SARS-CoV-2 gene sequence, and have the advantages of being easy to operate, high in sensitivity, strong in specificity, free of PCR amplification conditions, good in stability,economical, practical and the like; and thus, needs of rapid clinical diagnosis and screening can be met.

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Dual-loop-mediated isothermal amplification technology based probe for detecting novel coronavirus, primer, kit and detection method

NºPublicación: CN111088406A 01/05/2020

Solicitante:

MEDCAPTAIN MEDICAL TECH CO LTD

Resumen de: CN111088406A

The invention provides a dual-loop-mediated isothermal amplification technology based primer for detecting a novel coronavirus. The primer comprises a first primer group and a second primer group, wherein the first primer group comprises a first inner primer pair shown in SEQ ID. No. 3-4, a first outer primer pair shown in SEQ ID. No. 5-6 and a first loop primer pair shown in SEQ ID. No. 7-8; andthe second primer group comprises a second inner primer pair shown in SEQ ID. No. 9-10, a second outer primer pair shown in SEQ ID. No. 11-12 and a second loop primer pair shown in SEQ ID. No. 13-14.The first primer group and the second primer group can rapidly and specifically amplify different target genes of the novel coronavirus separately. The invention further provides a probe for detectingthe novel coronavirus, a kit and a method.

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mVSV virus vector and virus vector vaccine, and COVID-19 vaccine based on mVSV mediation

NºPublicación: CN111088283A 01/05/2020

Solicitante:

SUZHOU AOTEMING PHARMACEUTICAL TECH CO LTD

Resumen de: CN111088283A

The invention provides an mVSV virus vector, i.e., attenuated mVSV obtained after multiple modification mutations occur to an M protein amino acid site of a wild Indiana strain VSV, and an optimized heterologous antigen gene is preferentially integrated to a double cloning site area of an mVSV packaging core plasmid pmVSV-Core at the same time. The mVSV virus vector vaccine comprises a heterologous antigen gene which fuses or embeds a target virus between G and L genes of an mVSV vector envelope, wherein the antigen gene comprises an enveloped and embedded antigen gene encoding the target virus, an embedded combination antigen gene or a fused antigen gene; the mVSV virus vector is embedded or fused with a dominant antigen of spike protein S of an SARS-CoV-2 pathogen; the dominant antigen is preferably selected from a receptor binding domain of spike protein S, namely RBD; and a COVID-19 vaccine based on mVSV mediation is formed. The vaccine has good prevention or treatment effect on COVID-19 infected people.

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Disinfectant bomb - Disinfectant dispersal system for small, medium and large areas. Disinfectant slow release spray for all modes of transport, homes and offices.

NºPublicación: AU2020100453A4 30/04/2020

Solicitante:

GIUMELLI COLIN BOYD MR [AU]

Resumen de: AU2020100453A4

Decontamination Dispersal Aerosol Unit for indoor hands-free use, said unit will come in range of sizes suitable for public and private transportation, office spaces, and private homes. The unit will deploy an aerosol variant of the disinfectant, covering all exposed areas (within specified coverage capabilities). This product will mitigate existing risks (e.g. viruses such as COVID-19) within essential services and industries allowing best opportunity for business as usual functions.

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Aerosol inhalation protection hood

NºPublicación: CN210409163U 28/04/2020

Solicitante:

PEKING UNIV THIRD HOSPITAL PEKING UNIV THIRD CLINICAL MEDICAL COLLEGE

Resumen de: CN210409163U

The utility model provides an aerosol inhalation protection hood. The aerosol inhalation protection hood comprises a cap body, a hood body and a visual window, the cover body extends downwards from the lower edge of the cap body, and a closed space is defined below the cap body. The visual window is arranged on the cover body and is tightly connected with the cover body, and a communicating pipe is arranged on the visual window and extends from the outside of the closed space to the inside of the closed space. An air inlet valve and an exhalation valve are further arranged on the visual window, and a buckle is arranged on the side face of the visual window and used for fixing the atomizer. A self-adhesive buckle is arranged at the bottom of the mask body, and an elastic band is arranged along the bottom edge of the mask body. According to the protective hood, the spreading range of aerosol in the aerosol inhalation treatment process can be reduced to the maximum extent; under the condition that a patient infected with the novel coronavirus is unfavorable for aerosol inhalation treatment, the aerosol inhalation treatment method is widely applied to clinic, the cure rate of the patient is increased, the death rate is reduced, the exposure risk of medical personnel is reduced, and the infection possibility of the medical personnel and related personnel is reduced.

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Inflatable gas-phase efficient inactivation novel coronavirus equipment

NºPublicación: CN210409079U 28/04/2020

Solicitante:

GUANGDONG QINLIAN CHANGSHI TECH CO LTD

Resumen de: CN210409079U

The utility model discloses a novel inflatable gas-phase efficient inactivation coronavirus device. The device comprises an arch-shaped air bag, supporting air bags communicated with an inner cavity of the arch-shaped air bag are arranged on the front portion and the rear portion of the bottom end of the arch-shaped air bag, inflation and deflation valves are arranged on the supporting air bags, and at least two arch-shaped chlorine dioxide channels are arranged on the arch-shaped air bag at equal intervals from left to right. The utility model discloses inflatable gas-phase efficient inactivation novel coronavirus equipment. Inflatable arched air bags and supporting air bags are arranged; when in use, the arrangement can be completed only by inflating; assembly is convenient and fast, thechlorine dioxide channels are separately arranged at equal intervals in the arch-shaped air bag; chlorine dioxide is more uniformly distributed in the inactivation space, the concentration of chlorine dioxide in the inactivation space is ensured, the inactivation effect is improved, and the occupied space of the whole inactivation equipment can be reduced only by discharging gas in the supportingair bag and the arched air bag through the inflation and deflation valve during transportation, so that the inactivation equipment is convenient to fold and transport.

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Composition, kit and method for detecting and typing viruses causing respiratory tract infection and application of composition, kit and method

NºPublicación: CN111074011A 28/04/2020

Solicitante:

SANSURE BIOTECH INC

Resumen de: CN111074011A

The invention relates to the field of molecular biology detection, in particular to detection of novel coronavirus, influenza A virus and influenza B virus. The invention provides a composition for detecting the viruses, and meanwhile, the invention further provides a kit containing the composition, application of the composition and a method for detecting and typing the viruses causing respiratory tract infection. The composition is combined with a fluorescent probe method, three viruses causing respiratory tract infection can be detected and typed at the same time in one tube, and the composition, the kit and the method have the advantages of being low in cost, high in flux, short in consumed time, easy and convenient to operate and capable of avoiding false positive caused by cross among samples and environmental pollution.

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Method and device for screening candidate drugs for COVID-19

NºPublicación: CN111081316A 28/04/2020

Solicitante:

GENEIS TECH BEIJING CO LTD

Resumen de: CN111081316A

The invention discloses a method and device for screening COVID-19 drugs. On the basis of obtaining sequence similarity information between viruses and structure similarity information between pharmaceutical chemical structures, a heterogeneous network based on virus sequence similarity and drug similarity is constructed, and training is performed on the constructed data set by using a random walkalgorithm so as to obtain a COVID-19 drug screening model. Based on the drug screening model, drugs related to new coronal pneumonia can be effectively screened. According to the method, the researchand development cost of the COVID-19 drugs can be reduced, and the screening speed and accuracy of the COVID-19 drugs exceed those of representative methods applied to other bioinformatics fields.

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COVID-19 (coronavirus disease 2019) nucleic acid testing method capable of increasing accurate rate

NºPublicación: CN111074008A 28/04/2020

Solicitante:

NANJING SYNTHGENE MEDICAL TECH CO LTD

Resumen de: CN111074008A

The invention relates to a COVID-19 (coronavirus disease 2019) nucleic acid testing method capable of increasing the accurate rate. firstly, a reversal reaction is performed in a reversal reaction system, so that RNA of polyA is subjected to reverse transcription under the assistance of reverse transcriptase and oligo (dT) to form cDNA of poly (T); meanwhile, cDNA subjected to reverse transcription is subjected to an RPA reaction for a period of time for further amplification; an amplified product is mixed with a QPCR (real-time quantitative PCR detecting system), and the mixture is subjectedto a chain reaction on a QPCR instrument and then sequentially subjected to denaturation, reannealing and final extended chain circular reaction respectively; fluorescence signal intensity is collected and detected through detection equipment, qualitative or semiquantitative analytic determination on target segments, and finally, the virus detection result of a patient is judged according to obtained different fluorescence signal data. According to the technical scheme, the COVID-19 nucleic acid testing method which is high in specificity, accurate is result, low in false negative probability,capable of monitoring each stage from the early period to the later period of infection of the patient and capable of increasing the accurate rate can be provided.

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Isothermal amplification kit for detecting SARS-COV-2 and primer probe set

NºPublicación: CN111074007A 28/04/2020

Solicitante:

SHANGHAI DIFEI MEDICAL LABORATORY CO LTD

Resumen de: CN111074007A

The invention discloses an isothermal amplification kit for detecting SARS-COV-2 and a primer probe set. The kit comprises (1) inactivated lysate; and (2) an isothermal amplification system: a reaction buffer solution Buffer A, magnesium acetate Buffer B, negative control, nuclease-free water, a primer probe set and RAA enzyme. The lysate is used for rapid inactivation and release of viral nucleicacid, an isothermal amplification technology is utilized for rapidly enriching and amplifying a target area, whether a specific amplified product exists is rapidly determined through combination of aprobe with modification groups and a product with biotin, by a lateral chromatography technology and by use of colloidal gold developing. The kit is simple to operate, professional extraction reagents and detection instruments are not required limitation of detection laboratories and professionals is freed, the kit can perform rapid detection in an instrument-free state outdoors, the whole process only needs 30 min, and reading is very convenient.

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Device used for blocking infecting of diseases such as novel coronavirus spread by droplets

NºPublicación: CN111053984A 24/04/2020

Solicitante:

SHANDONG DAIYOU MEDICINE TECH CO LTD

Resumen de: CN111053984A

The invention provides a device used for blocking infecting of diseases such as novel coronavirus spread by droplets. The device comprises a chemical sterilization and disinfection unit, a physical sterilization and disinfection device, an air filter, a hood and other auxiliary unit. Different combinations of the units of the device can achieve two work states, the positive-pressure work state andthe negative-pressure work state. When the device is in the positive-pressure work state, the hood is full of sterilized and disinfected air, the pressure is higher than environment pressure, and thedevice is suitable for healthy personnel working in environments where people are likely to be infected. When the device is in the negative-pressure state, the internal pressure of the hood is lowerthan the environment pressure, air exhaled by users is exhausted into the environment after being sterilized and disinfected, and the device is suitable for being used by suspected infected patients or diagnosed infectious victims. According to the device capable of reducing the concentrations of bacterial viruses in the local environment through direct sterilization and disinfection, bacterial viruses are eliminated from the source and are killed before being diffused, healthy personnel who have to work in the environment are protected, and the patient recovery process is promoted.

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Application of 2019-nCoV3CL hydrolase inhibitor and IL-6 monoclonal antibody in preparation of treatment novel coronavirus pneumonia drug

NºPublicación: CN111053909A 24/04/2020

Solicitante:

UNIV NANTONG

Resumen de: CN111053909A

The invention discloses application of a 2019-nCoV3CL hydrolase (Mpro) inhibitor and an interleukin-6 (IL-6) monoclonal antibody in preparation of a treatment novel coronavirus pneumonia drug, and belongs to the technical field of medicines. Through establishing a Vero E6 cell and macrophage Thp-1 co-culture model inoculated with novel coronavirus virus 2019-nCoV, and simulating a process of generating inflammatory response by novel coronavirus virus in a cell body; the combined application of the inhibitor aiming at 2019-nCoV Mpro and the monoclonal antibody for reversing macrophage M1 type pro-inflammatory polarization is designed, and the result shows that the combined application of the inhibitor and the monoclonal antibody is beneficial to cure and prognosis recovery of novel coronavirus pneumonia.

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LAMP primer combination and test kit for detecting novel coronavirus

NºPublicación: CN111057798A 24/04/2020

Solicitante:

HUASHAN HOSPITAL FUDAN UNIV

Resumen de: CN111057798A

The invention discloses a LAMP primer combination and a test kit for detecting novel coronavirus. The primer combination is selected from is selected from any one or more of a primer group 1 as shownin SEQ ID NO: 3-SEQ ID NO: 6, a primer group 2 as shown in SEQ ID NO: 7-SEQ ID NO: 10, a primer group 3 as shown in SEQ ID NO: 11-SEQ ID NO: 14, a primer group 4 as shown in SEQ ID NO: 15-SEQ ID NO: 18, a primer group 5 as shown in SEQ ID NO: 19-SEQ ID NO: 22, a primer group 6 as shown in SEQ ID NO: 24-SEQ ID NO: 27, a primer group 7 as shown in SEQ ID NO: 28-SEQ ID NO: 31 and a primer group 8 asshown in SEQ ID NO: 32-SEQ ID NO: 35. The primer combination is combined with an LAMP technology, so that the detection result can be observed by naked eyes, complex auxiliary equipment is not needed,the primer combination is simple and easy to use, the detection result can be semi-quantitative by a fluorescent dye method, the detection sensitivity is high, and the sensitivity is high. And a convenient and rapid means is provided for the research of diagnosis and treatment drugs of the novel coronavirus related diseases.

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Primer, probe, test kit and method for real-time fluorescent quantitative PCR detection of novel coronavirus 2019-nCoV

NºPublicación: CN111057797A 24/04/2020

Solicitante:

AFFILIATED TONGJI HOSPITAL OF TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV OF SCIENCE & TECHNOLOGY

Resumen de: CN111057797A

The invention belongs to the technical field of virus detection, and particularly relates to a primer, probe, test kit and method for real-time fluorescent quantitative PCR detection of novel coronavirus 2019-nCoV. A single-tube double-fluorescence channel is adopted to simultaneously detect the existence of the novel coronavirus 2019-nCoV and reference gene Rnase P, and the existence of the novelcoronavirus 2019-nCoV RNA in specimens such as alveolar lavage fluid, nasopharyngeal swab, whole blood, serum, feces and tissues can be detected. The method is short in detection time period, and issuitable for clinical and bedside rapid detection of diagnosis; the virus detection specificity is high, and the accuracy is high; virus qualitative analysis and quantitative analysis are carried out,and the quantitative linear range is good; the detection sensitivity is high; the experimental result is good in repeatability and high in precision; and the reference gene is added into a detectionsystem, so that the quality of the whole process of extracting and amplifying the sample can be monitored through the detection result of the reference gene.

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Fluorescence immunochromatography device for detecting COVID-19 and using method thereof

NºPublicación: CN111060691A 24/04/2020

Solicitante:

SHENZHEN BIOEASY BIOTECHNOLOGY CO LTD

Resumen de: CN111060691A

The invention discloses a fluorescence immunochromatography device for detecting a novel coronavirus COVID-19 and a using method of the fluorescence immunochromatography device. The fluorescence immunochromatography device disclosed by the invention is high in sensitivity and strong in specificity, the accuracy is high, the detection sensitivity can reach 10pg/ml, the detection speed is high, theoperation is simple, the device is portable, the requirement for personnel is low, the operation of professionals is not needed, the detection cost is low, the device can be applied to preliminary screening of various places such as hospitals, airports, customs and disease control centers, the detection time (10-15 min) is short, a simpler, more convenient and faster field detection means is provided for suspected patient investigation and asymptomatic infected person screening, and therefore epidemic spreading is prevented as soon as possible.

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Inhibition Of TCR Signaling With Peptide Variants

NºPublicación: US2020123205A1 23/04/2020

Solicitante:

SIGNABLOK INC [US]

US_2019241618_A1

Resumen de: US2020123205A1

The present invention provides compositions comprising peptides derived from amino acid sequences (or from combinations thereof) of fusion and other protein regions of various viruses, including but not limited to, severe acute respiratory syndrome coronavirus, herpesvirus saimiri, human herpesvirus 6, Lassa virus, lymphocytic choriomeningitis virus, Mopeia virus, Tacaribe virus, Friend murine leukemia virus; human T lymphotropic virus type 1; herpesvirus ateles; Marburg virus; Sudan Ebola virus; Zaire Ebola virus, and comprising L- and/or D-amino acids and combinations thereof, which affect T cells by acting on the T cell antigen receptor (TCR). More specifically, the peptides act on the TCRαβ-CD3δε-CD3γε-ζζ signaling complex. Yet more specifically, the peptides act on the TCRα/CD3δε/ζζ signaling module of TCR. The present invention further relates to the prevention and therapy of various T cell-related disease states involving the use of these compositions. Specifically, the compositions are useful in the treatment and/or prevention of a disease or condition where T cells are involved or recruited. The compositions of the present invention also are useful in the production of medical devices comprising peptide matrices (for example, medical implants and implantable devices).

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NOVEL QUINOLINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND ANTIVIRAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT

NºPublicación: WO2020080682A1 23/04/2020

Solicitante:

KOREA RES INST CHEMICAL TECH [KR]
PASTEUR INSTITUT KOREA [KR]
KOREA INST ORIENTAL MEDICINE [KR]

Resumen de: WO2020080682A1

The present invention relates to a novel quinolinone derivative, a preparation method therefor, and an antiviral composition containing same as an active ingredient. A novel quinolinone derivative provided in one aspect of the present invention exhibits an excellent inhibitory activity against a coronavirus infection, and thus can be effectively used as a pharmaceutical composition for preventing or treating a disease caused by a coronavirus infection, that is, MERS.

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PROPOSED THERAPY TO REDUCE EFFECTS OF VIRAL INFECTIONS (may help with COVID 19) 16 Mar. 2020

NºPublicación: AU2020100400A4 23/04/2020

Solicitante:

THOMPSON EDGAR

Resumen de: AU2020100400A4

PROPOSED THERAPY TO REDUCE EFFECTS OF VIRAL INFECTIONS The disclosed proposed therapy to reduce effects of viral infections is a combination of lifestyle changes, vitamin supplements and prescription medicines that will reduce the impact of viral infections by boosting the body's immune system. The outcomes of adopting and implementing these strategies will amaze both young an older people. For example, younger people may only have to implement the lifestyle changes to have an extremely healthy outcome.

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Kitchen garbage fermentation system and method capable of killing novel coronavirus and influenza virus

NºPublicación: CN111040935A 21/04/2020

Solicitante:

AZUREFLYING ZHEJIANG TECH CO LTD

Resumen de: CN111040935A

The invention discloses a kitchen garbage fermentation system and a method capable of killing novel coronavirus and influenza virus. The kitchen garbage fermentation system comprises a fermentation bin, a controller and a heat source; the lower half portion of the cross section of the fermentation bin is semicircular, the upper half portion of the cross section of the fermentation bin is rectangular, and the side length of the long side of the rectangular part is equal to the diameter of the semicircular part; the fermentation bin comprises a stirring part, a heating layer, a temperature sensor, a humidity sensor, a disinfection sprayer, a humidifier and an air exchange valve; and the stirring part rotates forwards or reversely or stops according to an instruction sent by the controller;the heating layer is arranged at the lower half portion of the fermentation bin, and the heat source is used for heating the heating layer; the temperature sensor and the humidity sensor are arrangedon the side wall of the upper half portion; and the disinfection sprayer, the humidifier and the air exchange valve are arranged on the top wall of the fermentation bin. The fermentation system comprises the disinfection sprayer for disinfecting and killing novel coronavirus, influenza and other viruses, the fermentation process is fully automatically controlled by the controller, and the kitchengarbage is effectively disinfected and sterilized.

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Application of COVID-19 infection host marker

NºPublicación: CN111041089A 21/04/2020

Solicitante:

GUANGZHOU VISION GENE TECH CO LTD

Resumen de: CN111041089A

The invention relates to an application of a COVID-19 infection host marker, and belongs to the technical field of gene detection. The COVID-19 infection host marker can be applied to preparation of aCOVID-19 infection detection reagent or detection equipment, and the host marker comprises at least one of RNR1, MFSD11, SYNE3 and SLC10A3 genes. According to the invention, the gene expression difference between a COVID-19 positive pneumonia group patient and a COVID-19 negative pneumonia group patient is analyzed, an obtained gene with differential expression is used as the host marker, can beused for assisting COVID-19 infection diagnosis, can make up for the defect of false negative in virus nucleic acid detection to a certain extent, and improve the diagnosis capability on COVID-19.

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Primer probe combination for detecting six respiratory viruses, kit and application

NºPublicación: CN111041129A 21/04/2020

Solicitante:

CAPITALBIO CORP

Resumen de: CN111041129A

The invention relates to the field of medical detection, in particular to a primer probe combination for detecting six respiratory viruses, a kit and application. According to the kit provided by theinvention, a method of combining isothermal amplification and a micro-fluidic chip is adopted; the kit can accurately detect novel coronavirus (2019-nCoV) S and N target genes and influenza A virus, novel influenza A H1N1 virus (2009), influenza A H3N2 virus, influenza B virus and respiratory syncytial virus at the same time, and the purpose of distinguishing the novel coronavirus from common influenza virus is achieved. The kit disclosed by the invention has the advantages of multiple detection indexes, simplicity and convenience in operation, short detection time and the like, six virus indexes can be simultaneously detected by one-time sample adding, the time from sample treatment to report is within 1.5 hours, and the kit is more time-saving and labor-saving than qPCR method.

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Colloidal gold immunochromatography device for combined detection of COVID-19 antigen and antibody and use method thereof

Nº publicación: CN111024954A 17/04/2020

Solicitante:

SHENZHEN BIOEASY BIOTECHNOLOGY CO LTD

Resumen de: CN111024954A

The invention discloses a colloidal gold immunochromatography device for combined detection of a novel coronavirus COVID-19 antigen and antibody and a use method thereof. Through simultaneously detecting a novel coronavirus COVID-19 antigen and a specific IgM antibody and IgG antibody thereof, the immunology reaction state of the organism can be accurately judged, so that an accurate detection result is given according to the detection result, the detection rate of the new coronavirus is improved, a false negative result is avoided, missing detection is prevented, the detection accuracy is further improved, and help is provided for clinical diagnosis and treatment of the new coronavirus pneumonia. The colloidal gold immunochromatography device is high in specificity, high in detection speed and easy and convenient to operate, does not need special equipment or operation of professionals, and can be applied to preliminary screening of various places such as communities, primary hospitals, airports, customs and even families.

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