BIOIMPRESIÓN 3D

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Resultados 91 resultados LastUpdate Última actualización 13/10/2019 [18:16:00] pdf PDF xls XLS




Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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THREE-DIMENSIONAL PRINTING OF COLLOIDAL BUILDING BLOCKS FOR WOUND HEALING MATERIALS

NºPublicación: WO2019195681A1 10/10/2019

Solicitante:
UNIV NORTH CAROLINA STATE [US]

Resumen de: WO2019195681A1

Bio-ink compositions comprising bio-compatible microgels or nanogels are described. The bio-inks can comprise, for example, micro- or nanogels comprising crosslinked poly(N-isopropylacrylamide) (poly-NIPam). The bio- inks can further comprise viscosity control agents, such as poly(ethylene glycol) (PEG), and/or surface tension agents. Three-dimensional (3D) printing (e.g., piezoelectric printing) of the bio-inks can provide 3D printed materials comprising microgel or nanogel assemblies of the bio-ink compositions. These materials can be used as scaffolds for preparing biological tissues for use, for instance, in regenerative medicine.



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APPARATUS AND METHOD FOR THE AUTOMATED PRODUCTION OF CUSTOMIZABLE DOSAGE FORMS

NºPublicación: WO2019193060A1 10/10/2019

Solicitante:
DE GIORGI CARLO [IT]

Resumen de: WO2019193060A1

An apparatus (10, 100, 1000) for the automated production of customizable dosage forms, comprising a sterile chamber (20) inside which a dosage form is formed, comprising: - a core supporting assembly (30) for retaining a core (9) inside the sterile chamber (20), - one or more dispensing devices (50), each of which is configured to emit, in a controlled manner, in the direction of the core (9), a jet (g) of a pharmaceutical compound, - a motor assembly (40), adapted to transmit a rotation about a central rotation axis (Y) to the core supporting assembly (30) and with it to the core (9) or to at least one dispensing device (50); the motor assembly (40) and the dispensing devices (50) being configured so that during rotation the dispensing devices (50) deposit one or more layers (1', 1'') of a predefined thickness of pharmaceutical compounds on a perimetric portion of the core (9).



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IMPLANT MADE OF FIBRE-REINFORCED PLASTIC

NºPublicación: US2019307534A1 10/10/2019

Solicitante:
SCHWITALLA ANDREAS [DE]
MUELLER WOLF DIETER [DE]

Resumen de: US2019307534A1

A customizable implant made of plastic including a thermoplastic which is reinforced with long fibers arranged multidirectionally in a targeted manner and has a modulus of elasticity E of 10-70 GPa is provided. A system for producing a customizable implant including a device for collecting patient data regarding the environment into which an implant is to be inserted, a computer program for creating a model for a customized implant based on the patient data collected, and a device for producing the customized implant based on the calculated model by means of 3D printing and/or laser sintering is also provided.



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INTERFACE DEVICE FORMABLE BY ADDITIVE MANUFACTURING PROCESS

NºPublicación: US2019307980A1 10/10/2019

Solicitante:
KONINKLIJKE PHILIPS NV [NL]

Resumen de: US2019307980A1

An interface device is structured to be connected in fluid communication with a source of breathing gas and to provide a flow of breathing gas to the airways of a patient. The interface device includes a support (24), a deformable portion (28) situated on the support, and an interface portion (32) situated on the deformable portion and being structured to be engaged with the patient in the vicinity of the airways, with the deformable portion including a plurality of deformable elements (36) that form a lattice structure and that are connected with the support at a plurality of spaced apart points of connection (44) on the support. The interface device may be formed via an additive manufacturing process.



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Dental Prosthetic Moulds and Moulding Methods

NºPublicación: US2019307537A1 10/10/2019

Solicitante:
FUNG JOHN [AU]

Resumen de: US2019307537A1

A method of forming a plurality of compression moulds for moulding prosthetic tooth elements is disclosed. A natural tooth surface or a model of the natural tooth surface is scanned to obtain scan data. Based on the scan data, a first compression mould is formed comprising a first mould surface, the first mould surface having a shape corresponding to a shape of a natural tooth surface increased in size by a first scale factor. Based on the scan data, a second compression mould is formed comprising a second mould surface, the second mould surface having a shape corresponding to the shape of the natural tooth surface increased in size by a second scale factor, the second scale factor being different from the first scale factor. Prosthetic tooth elements and dental prostheses formed using the method are also disclosed.



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Polymeric Materials and Articles Manufactured There From

NºPublicación: US2019309238A1 10/10/2019

Solicitante:
PROCTER & GAMBLE [US]
VIRGINIA TECH INTELLECTUAL PROPERTIES INC [US]

Resumen de: US2019309238A1

A water-soluble polyurethane derived from: polyethylene glycol, polyethylene glycol-block-polypropylene glycol-block-polyethylene glycol polymer, polypropylene glycol-block-polyethylene glycol-block-polypropylene and mixtures thereof, 1,1′-Carbonyldiimidazole, polyamine and mixtures thereof.



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Three Dimensional Bioprinted Tumor Models for Drug Testing

NºPublicación: US2019309264A1 10/10/2019

Solicitante:
ORGANOVO INC [US]
UNIV OREGON HEALTH & SCIENCE [US]

Resumen de: US2019309264A1

Described are three-dimensional, engineered, biological cancer models, methods of producing the same, and methods of identifying a therapeutic agent for cancer in an individual utilizing the three-dimensional, engineered, biological cancer models.



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Preparation and Applications of 3D Bioprinting Bioinks for Repair of Bone Defects, Based on Cellulose Nanofibrils Hydrogels with Natural or Synthetic Calcium Phosphate Particles

NºPublicación: US2019307923A1 10/10/2019

Solicitante:
CELLINK AB [SE]

Resumen de: US2019307923A1

The present invention relates to preparation of bioink composed of cellulose nanofibril hydrogel with native or synthetic Calcium containing particles. The concentration of the calcium containing particles can be between 1% and 40% w/v. Such bioink can be 3D Bioprinted with or without human or animal cells. Coaxial needle can be used where cellulose nanofibril hydrogel filled with Calcium particles can be used as shell and another hydrogel based bioink mixed with cells can be used as core or opposite. Such 3D Bioprinted constructs exhibit high porosity due to shear thinning properties of cellulose nanofibrils which provides excellent printing fidelity. They also have excellent mechanical properties and are easily handled as large constructs for patient-specific bone cavities which need to be repaired. The porosity promotes vascularization which is crucial for oxygen and nutrient supply. The porosity also makes it possible for further recruitment of cells which accelerate bone healing process. Calcium containing particles can be isolated from autologous bone, allogenic bone or xenogeneic bone but can be also isolated from minerals or be prepared by synthesis. Preferable Calcium containing particles consist of β-tricalcium phosphate which is resorbable or natural bone powder, preferably of human or porcine origin. The particles described in the present invention have particle size smaller than 400 microns, or more preferably smaller than 200 microns, to make it possible to han



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PRINTING DEVICE AND COMPOSITION COMPRISING MAGNETIC COLOR CHANGEABLE MICROCAPSULES

NºPublicación: WO2019193169A1 10/10/2019

Solicitante:
SOC BIC [FR]

Resumen de: WO2019193169A1

This disclosure relates to a printing device for printing or dispensing a curable printing composition which is capable of changing color in response to the application of a magnetic field in the non-cured state. The printing device may be a handheld device such as a portable pen. The present disclosure further relates to curable compositions, cartridges and methods which may be used in combination with the aforementioned printing devices or in other applications.



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BIODEGRADABLE ELASTIC HYDROGELS FOR BIOPRINTING

NºPublicación: WO2019195256A1 10/10/2019

Solicitante:
UNIV TEXAS [US]
UNIV NORTHEASTERN [US]

Resumen de: WO2019195256A1

Disclosed herein are hydrogel compositions comprising a triblock copolymer having a formula A-B-A, wherein A is a polycaprolactone (PCL) block or a polyvalerolactone (PVL) block and B is a polyethylene glycol (PEG) block. Also disclosed are methods of making a hydrogel comprising providing a photoinitiator and a triblock copolymer having a formula A-B-A, wherein the triblock copolymer comprises one or more ethylenically unsaturated moieties; and photocrosslinking the triblock copolymer, thereby forming a hydrogel. Also disclosed are methods of printing a three-dimensional (3D) article comprising extruding a printing composition from a deposition nozzle moving relative to a substrate, the printing composition comprising a photoinitiator and any herein disclosed triblock copolymer, wherein the triblock copolymer comprises one or more ethylenically unsaturated moieties; depositing one or more layers comprising the printing composition on the substrate; and photocrosslinking the triblock copolymer to form the printed 3D article.



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生物3D打印植入凝胶及其在软组织缺损修复中的应用

NºPublicación: CN110302430A 08/10/2019

Solicitante:
上海交通大学医学院附属第九人民医院

Resumen de: CN110302430A

一种组合物,包括聚乙二醇、去细胞细胞外基质和透明质酸的溶液。其中,聚乙二醇浓度1.5w/v%~3.5%w/v,去细胞细胞外基质浓度10w/v%~30w/v%和透明质酸浓度10g/L~20g/L。本发明的组合物具有良好生物相容性,具有温敏特性,随着温度升高,逐渐固化,运用3D打印技术制成模拟细胞外基质形态的凝胶,有利于软组织切除手术后形成的空腔内的新生肉芽组织的粘附生长和再生修复,促进创伤愈合。



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用于骨组织工程的钛酸钡压电陶瓷支架及其制备方法

NºPublicación: CN110304917A 08/10/2019

Solicitante:
上海理工大学

Resumen de: CN110304917A

本发明提供了一种用于骨组织工程的钛酸钡压电陶瓷支架,其特征在于,包括:将60‑80wt%的包覆生物活性玻璃的钛酸钡粉末、10‑20wt%乙醇、5‑15wt%的粘结剂聚乙烯吡咯烷酮混合,搅拌,得到打印墨水;使用三维建模软件设计50%‑90%孔隙率的多孔模型,进行三维打印,得到多孔支架素坯;将多孔支架素坯置于管式炉中烧结,得到用于骨组织工程的钛酸钡压电陶瓷支架。本发明以包覆生物活性玻璃的钛酸钡为原料,采用三维打印技术制备出多孔复合陶瓷支架,具有很好的生物活性和压电性,能够精确控制支架的内部结构,成型过程简单。



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一种Ag-DBT/PVDF复合骨支架及其制备方法

NºPublicación: CN110302429A 08/10/2019

Solicitante:
江西理工大学

Resumen de: CN110302429A

本发明提供了一种Ag‑DBT/PVDF复合骨支架及其制备方法,所述复合骨支架由PVDF基体以及分散于PVDF基体中的Ag‑DBT组成,所述Ag‑DBT为表面负载有纳米银的聚多巴胺包覆BaTiO,所述制备方法采用多巴胺对BaTiO进行表面修饰得到DBT粉体;将DBT粉体分散至含Ag的溶液中,通过原位还原反应在BaTiO颗粒表面形成单质银,得到Ag‑DBT复合颗粒;将PVDF粉体与Ag‑DBT复合颗粒通过液相混合得到Ag‑DBT/PVDF复合粉体;所述复合粉体通过选择性激光烧结得到Ag‑DBT/PVDF复合骨支架;该方法利用BaTiO作为纳米银载体,不但可以强化加载在陶瓷颗粒上的极化电压,使外加电压足以实现BaTiO陶瓷颗粒中偶极子的完全偏转,增强复合材料支架压电性能,改善其生物性能,而且可以促进纳米银在PVDF基体中的分散,赋予复合材料支架良好的抗菌性能。



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一种具有梯度孔结构的全层皮肤组织工程支架的制备方法

NºPublicación: CN110302432A 08/10/2019

Solicitante:
华南理工大学

Resumen de: CN110302432A

本发明涉及组织工程皮肤技术领域,具体为一种具有梯度孔结构的全层皮肤组织工程支架的制备方法,采用溶胶‑凝胶技术探索制备了有机‑无机杂化材料,依照皮肤组织的结构和成分特征,选用CS‑Si‑Gel组分作为真皮层,CS‑Si组分作为表皮层,采用多喷头打印系统成功构建出具有梯度孔结构的全层皮肤组织工程支架。本发明所选材料具备优异的生物相容性、抗菌性等,所制备支架具有结构仿生的优势。此外,采用三维扫描建模技术进行分层打印,逐层堆叠,可实现个性化定制,从而提高了全层皮肤缺损修复的成功率。其亦可用于体外皮肤模型的研究,在药物和化妆品测试以及肿瘤研究方面均将发挥重要作用。



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基于活细胞3D打印的软骨-骨-骨髓复合组织结构及方法

NºPublicación: CN110302428A 08/10/2019

Solicitante:
中国人民解放军陆军军医大学第一附属医院

Resumen de: CN110302428A

本发明公开了一种基于活细胞3D打印的软骨‑骨‑骨髓复合组织结构及方法,采集骨组织的生物信息,输入计算机进行仿生建模,配制适用软骨、成骨、间充质干、血管内皮等细胞的生物墨水;配制打印密致骨区域的硬材料硬材料;配制各种铸型剂;将活细胞按一定的密度接种于相应的生物墨水中;将各种类型的打印墨水分别加载于打印机料仓,设置打印参数后进行3D打印,打印成型的骨组织在组织工程仿生培养器中进行培养,一定时间后运用温控或酶控或光控的方法,于不同的时间祛除铸型剂材料,在软骨‑骨‑骨髓复合组织外部接枝人工血管,在组织工程仿生培养器内连续循环灌注培养,实现打印组织的预成熟。其实现3D打印骨组织的长期存活和生物功能。



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一种3D打印复合生物墨水材料及其制备方法与应用

NºPublicación: CN110302419A 08/10/2019

Solicitante:
暨南大学

Resumen de: CN110302419A

本发明公开了一种3D打印复合生物墨水材料及其制备方法与应用。该复合生物墨水材料的组成成分包括生物降解聚酯、增强增韧剂和三元溶剂体系。其中,三元溶剂体系按质量百分比含有机溶剂40~90%、表面活性剂5~45%、增塑剂5~45%。相比于单一低沸点有机溶剂体系,三元溶剂体系不仅提高了复合生物墨水的可打印性,也提高了生物降解聚酯基体与增强增韧剂之间的界面结合,而且,增强了打印过程中纤维层与层之间的界面粘接,可赋予3D打印复合多孔支架良好的三维结构和力学性能。此外,所用增强增韧剂可进一步改善生物降解聚酯的力学性能和成骨活性,赋予复合多孔支架优异的促骨组织修复能力。



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Printhead device for 3D bio-printer

NºPublicación: US10434713B1 08/10/2019

Solicitante:
UNIV TAIYUAN TECHNOLOGY [CN]

Resumen de: US10434713B1

A printhead device is provided. The printhead device includes a cell tube, a cell tube rubber plug covering the cell tube, a connector arranged at an end of the cell tube, and a fixing knob fixed to the connector and communicating with a printing nozzle through a bottom liquid tube. A fixing clip is provided on the upper part of the cell tube, and a stepping motor box is provided on the upper end of the fixing clip. An air valve box is arranged on the upper side of the stepping motor box, and a rotary air valve is provided in the air valve box. The rotary air valve communicates with the inner cavity of the cell tube through an internal vent tube, and with an air valve straight tube or an air valve gooseneck tube.



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IMPROVEMENTS RELATING TO PRINTING

NºPublicación: ES2726532T3 07/10/2019

Solicitante:
MANREX PTY LTD

Resumen de: WO2013016757A1

An assembled blister package (1) has a blister sheet (11) formed with blisters (2) sealed by a foil backing sheet (4). The blister package (1) is sandwiched between opposite sides of a folded card (not shown) to stiffen it. Each of these sides has a rectilinear array of windows, the blisters protruding through one array of windows and the other array of windows defining discrete areas on which print describing the contents of the blisters beneath, is to be applied. A header sheet on which a bar-code is printed is attached to the backing sheet and a reader (23) is positioned to read the bar-code and extract from it information such as a description of the contents of each of the blisters and their respective positions in the package. Information relating to the identification of the contents of a particular blister and the identity of the patient is fed to an ink-jet printer (31) and two stepping motors (22 and 30) are used to control the position of the printer with respect to the backing sheet. As the printer does not make physical contact with the backing sheet, it can be spaced from it by a sufficient distance to enable it to pass over the card without obstruction despite the card being salient with respect to the surface of the backing sheet. Printing can thus proceed quickly without obstruction by parts of the card and without having to vary the distance between the printer and the irregular surface over which it passes. This has the advantage that no precise alignment o



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DEVICE FOR PRODUCING 3D-PRINTED ACTIVE SUBSTANCE-RELEASING SYSTEMS WITH ACTIVE SUBSTANCE DEPOTS, AND METHOD FOR PRODUCING 3D-PRINTED ACTIVE SUBSTANCE-RELEASING SYSTEMS

NºPublicación: WO2019185725A1 03/10/2019

Solicitante:
UNIV ROSTOCK [DE]

Resumen de: WO2019185725A1

The invention is based on the problem of providing a device and a method that resolve the disadvantages of the prior art and enable the construction of high-resolution active substance-releasing systems of any form and with locationally selective active substance depots. This problem is solved by a device for producing a 3D-printed active substance-releasing system with active substance depots according to claim 1. The device is designed such that a radiation source in operation causes a polymerisation of a layer of the base material on the construction platform and that an inkjet printhead incorporates an active substance mixture, which has at least one active substance, into the base material in a locationally selective manner. The problem is also solved by a method for producing a 3D-printed active substance-releasing system with active substance depots according to claim 16 by providing a trough, in which a base material and a construction platform are arranged, and polymerising selected regions of a layer of the base material on the construction platform and introducing, by means of an inkjet printing method, an active substance mixture, which has at least one active substance, into the base material and/or polymerised base material in a locationally selective manner in order to thereby create active ingredient depots in the active ingredient-releasing system.



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PRINTING DEVICE AND PRINTING METHOD

NºPublicación: WO2019187898A1 03/10/2019

Solicitante:
SCREEN HOLDINGS CO LTD [JP]

Resumen de: WO2019187898A1

This printing device prints an image on a front surface (91) of a granular object. The printing device comprises a conveyance mechanism, an imaging unit (102), a rear surface cut line detection unit, and a printing unit. The conveyance mechanism conveys the granular object while holding the granular object from a rear surface (92) side. The imaging unit (102) generates image data by imaging the front surface (91) and a side surface (93) of the granular object being conveyed. The rear surface cut line detection unit detects whether or not the rear surface (92) includes a cut line and detects the direction of the cut line on the basis of the image data. The printing unit performs printing on the front surface (91) of the granular object on the basis of the direction of the cut line detected by the rear surface cut line detection unit. Accordingly, while the direction of holding the granular object is not changed after the cut line in the rear surface (92) of the granular object is detected, an image can be precisely printed, along the detected cut line, on the front surface (91) of the granular object.



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PHOTOCURABLE RESIN COMPOSITION

NºPublicación: WO2019189566A1 03/10/2019

Solicitante:
KURARAY NORITAKE DENTAL INC [JP]

Resumen de: WO2019189566A1

The present invention provides a photocurable resin composition which has excellent modeling properties, while providing a cured product thereof with excellent flexibility, fracture resistance and water resistance. The present invention relates to a photocurable resin composition which contains (A) a urethanized (meth)acrylic compound, (B) a mono(meth)acrylic acid ester compound having no urethane bond, and (C) a photopolymerization initiator, and which is configured such that: the urethanized (meth)acrylic compound (A) is a (meth)acrylate which has, in each molecule, a urethane bond and at least one structure that is selected from the group consisting of polyesters, polycarbonates, polyurethanes, polyethers, poly-conjugated dienes and hydrogenated poly-conjugated dienes; and the mono(meth)acrylic acid ester compound (B) having no urethane bond contains at least one compound that is selected from the group consisting of mono(meth)acrylic acid ester compounds (b-I) represented by general formula (I) and mono(meth)acrylic acid ester compounds (b-II) represented by general formula (II).



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MEDICAL IMPLANTS AND OTHER ARTICLES OF MANUFACTURE BASED ON TRABECULAR BONE LATTICES

NºPublicación: WO2019191149A1 03/10/2019

Solicitante:
UNIV CALIFORNIA [US]
LI ALFRED [US]

Resumen de: WO2019191149A1

Novel articles of manufacture based comprising lattices based on trabecular bone, having a plurality of plates and interconnecting rods. The trabecular bone-inspired lattice may be designed based on the general alignment of plates and rods found in trabecular bone, including anisotropic lattices having one or more predominant axes of mechanical strength. Lumbar fusion implants and other implants are provided having a trabecular bone inspired lattice in which bone graft material may be packed and providing a scaffold for bone fusion and growth. The implants may be based on bone structures having a predominant axis of mechanical strength and may be deployed in sites with the predominant axis of mechanical strength aligned with the primary axis of mechanical stress, such as in the the spine.



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SPLINT DEVICE

NºPublicación: WO2019191248A1 03/10/2019

Solicitante:
NORTON SEAN C [US]

Resumen de: WO2019191248A1

A splint device for stabilizing and/or securing a limb or appendage in a fixed position is provided. The splint device can include a first plate member and a second plate member connected together at one end by a hinged connection member. The hinged connection member can be configured to allow each plate member to be rotated relative to one another and selectively locked into a fixed position. The splint device can include a third plate member connected to the second plate member by a second hinged connection. The rotation of each plate member relative to the other can allow the splint device to be selectively positioned in a fixed configuration to generally match the shape and contour of a limb or appendage in a desired configuration. The splint device permits the accommodation of a joint (elbow, wrist, knee, ankle), and may provide for multiple configurations at a splinted limb.



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APPARATUS AND METHODS FOR CREATION OF A PATIENT-SPECIFIC BODY PART OR MEDICAL INSERT

NºPublicación: US2019298526A1 03/10/2019

Solicitante:
MEDIPRINT LLC [US]

Resumen de: US2019298526A1

Methods and apparatus for generating a patient-specific replacement body part. DICOM may be used to describe an anatomical portion of a patient and features may be differentiated that relate to a various biological systems. A user or a controller may designate a portion of features that relate to a biological system to be produced in a tangible model. A data file is generated that represents a surface geometry of a three-dimensional object representative of the portion of the features that relate to the biological system. Fabrication apparatus is operated to produce the object, which includes a tangible three-dimensional model of features that relate to the biological system.



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SYSTEMS AND METHODS FOR DIGITIZING ELECTROCARDIOGRAMS

Nº publicación: US2019298204A1 03/10/2019

Solicitante:
CARDIOLOGS TECH SAS [FR]

Resumen de: US2019298204A1

The disclosure relates to systems and methods of converting a representation of a physiological signal (e.g., a non-digitized version such as a printed curve) into a digitized representation of the physiological signal of a subject. For example, a printed electrocardiogram (ECG) may be digitized using the systems are methods provided herein. The method may include receiving a digitized image of a printed curve representing the physiological signal of the subject, and detecting at least one region of interest having a portion of the physiological signal. For each of the regions of interest, the method may include extracting coordinates representing the physiological signal and registering the extracted coordinates.


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