Resumen de: WO2023094655A1

The invention relates to a medical device (1) for delivering a therapeutic agent by bio-printing, comprising a rod body (2) comprising - a bio-printing cartridge (4) arranged in proximity to the distal end of the rod body (2), comprising: - an upper layer comprising a solution comprising a therapeutic agent; and - an absorbent compound capable of converting the light energy of laser radiation into thermal energy and arranged in such a way as to cause heating of the solution comprising a therapeutic agent, so as to produce a jet of the solution; - an optical fibre (3) extending longitudinally inside a lumen of the rod body (2) in order to convey a laser flux to the absorbent compound.

Resumen de: CN116196479A

本发明公开了一种3D打印骨骼材料及其制备方法，属于生物医用材料技术领域，以重量份数计，所述3D打印骨骼材料包括以下原料：牛骨粉50～70份、聚醚醚酮8～15份、甲基丙烯酰胺明胶3～6份、β‑磷酸三钙5～10份和生物粘合剂4～10份。本发明提供的3D打印骨骼材料将牛骨粉和聚醚醚酮进行配合使用并作为3D打印的主要原料，辅以适宜配比的甲基丙烯酰胺明胶、β‑磷酸三钙和生物粘合剂，得到了一种兼具有优异生物相容性和促进成骨、骨诱导、骨传导特性的3D打印骨骼材料，克服了聚醚醚酮材料与骨组织之间存在的生物惰性，为聚醚醚酮材料和牛骨粉在骨移植材料领域应用提供了一条新的途径。

Resumen de: CN116196131A

本发明公开了一种采用记忆复原结构的义齿制作装置及其方法，涉及牙科器械技术领域，包括基座、调位组件和补齐组件，所述基座的顶部两侧设置有第一电推杆，且第一电推杆的输出端连接有锁位块，所述锁位块的外端设置有模体组件。本发明将组合成一体的齿体在连接体成型前与其固定，并采用3D打印具体牙齿细节的方式来制作义齿，能免去传统义齿制作时的“一颗颗”假牙植入，这使得设备在假牙植入过程中，只需进行单次位置对准即可保证整体假牙的位置精度，此外本设备所有的假牙均是与齿体衔接的，而齿体埋设在连接体内部，这使得本设备制作的义齿可模拟真实的牙齿与齿骨衔接关系，以保证义齿使用过程中的牢固度，降低假牙脱落的风险。

Resumen de: CN116196480A

本发明提供一种3D打印氢键交联超分子聚合物高强度水凝胶基半月板支架及其制备方法，通过制备低浓度的聚(N‑丙烯酰基脲胺)凝胶，对其进行反复挤压得到凝胶微颗粒体系，加入单体及光引发剂，配制打印墨水；利用3D打印技术，通过“挤出打印—辐照—溶剂交换”过程，构建高模量水凝胶半月板骨架；向模具中加入含N‑丙烯酰基甘氨酰胺、光引发剂的水溶液引发自由基聚合反应。本发明以3D打印高模量氢键交联水凝胶构建半月板骨架，模仿胶原纤维结构，提供高拉伸模量；以浇注柔性氢键交联水凝胶作为填充，模仿蛋白多糖成分，提供低压缩模量，实现了对天然半月板各向异性力学性能的模仿，在构建半月板替代物方面具有巨大的潜在应用价值。

Resumen de: CN116198113A

一种光固化3D打印PU赝复体制备方法，包括步骤有：步骤(1)、采集上颌缺损处的CT扫描数据；步骤(2)、根据步骤(1)得到的CT扫描数据，得到赝复体打印模型；步骤(3)、使用预先制备的光固化PU打印墨水对赝复体打印模型进行3D光固化打印得到的赝复体；光固化PU打印墨水的原料含有聚四亚甲基醚二醇PTMEG和异佛尔酮二异氰酸酯IPDI。该光固化3D打印PU赝复体制备方法的赝复体合成简易、机械性能良好、生物相容性好及力学性能强，而且本发明降低赝复体制作前印模的临床操作难度，缩短制作时间并能大幅提高赝复体的精度。

Resumen de: CN116196475A

本发明公开了一种3D打印曲率生物角膜的制备方法，包括以下步骤：在I型胶原的溶液中加入1‑乙基‑3(3‑二甲基氨丙基)碳化二亚胺、N‑羟基丁二酰亚胺和2，3‑环氧丙基三甲基氯化铵，制备得到改性胶原；将改性胶原加入可光交联GelMA溶液，在中性条件下溶解，得到3D打印墨水；将角膜基质细胞重悬于3D打印墨水中，得到生物墨水；将生物墨水装于3D打印料筒中，进行3D打印。本发明还公开了3D打印曲率生物角膜的制备方法制备得到的3D打印曲率生物角膜在预防角膜基质纤维化中的应用。本发明解决了大分子量胶原无法在中性条件下溶解的难题，制备的角膜具有完整的复杂结构，负载的细胞活性高，并且能预防纤维化的发生。

Resumen de: CN219112906U

本实用新型属于义齿制作技术领域，尤其为一种义齿激光熔融装置，包括工作台以及固定连接在所述工作台表面的L型板和安装在所述工作台表面的激光成型件，还包括设置在所述工作台表面的冷却组件，所述冷却组件包括固定连接在所述工作台表面的水箱以及固定安装在所述水箱表面的水泵和固定连接在所述水泵出水端的弯管，所述弯管远离所述水泵的一端固定安装有蒸发器，所述蒸发器和所述工作台固定连接，所述蒸发器的表面固定连接有输气管；有利于对成型后的义齿进行冷却，缩短义齿冷却所需要的时间，提高义齿加工效率，有利于加快义齿上方位置处的空气流通，从而降低义齿靠近其表面位置处的热量。

Resumen de: US2023165690A1

A spinal implant device is provided comprising a body structure and a movable door coupled or configured to couple to the body structure. The spinal implant device can include a distal end, a proximal end, two opposing side walls extending between the distal end and the proximal end, an upper wall, a lower wall, and a central cavity. The movable door is configured to open to allow the central cavity to be packed with material and the movable door is configured to close. A method is provided comprising providing a spinal implant device, packing the cavity with the material, closing the movable door, and inserting the spinal implant device between adjacent vertebrae. A method of manufacturing a spinal implant device is provided comprising 3D printing a spinal implant device, wherein the spinal implant device is 3D printed as one piece.

Resumen de: US2023165666A1

A parameter recommendation module is used to propose a recommendation for dental restoration material parameters. The recommendation takes into consideration final tooth color influencing factors such as underlying tooth stump color and color of restoration fastening material such that at least one output restoration characteristic value needed to achieve a final user-specific tooth color for at least one tooth layer of the restoration is proposed.

Resumen de: US2023165613A1

The present disclosure provides for a bone screw formed of continuous fibers, for example. The bone screw may include a first portion having a cylindrical shape and extending in a longitudinal direction from a first end to a second end, for example. In various embodiments, the first portion may include a thermoplastic material and/or be substantially formed of a thermoplastic material. In various embodiments, the bone screw may include a second portion coupled to the first portion and surrounding the first portion, at least partly, for example. In various embodiments, the second portion may include a plurality of layers, each layer comprising a continuous fiber material, for example. In various embodiments, the continuous fibers may be oriented longitudinally, diagonally, helically, radially, etc. In various embodiments, the second portion may define an exposed thread pattern and a leading tip.

Resumen de: US2023165965A1

The present invention provides new coumarin-polymer conjugates that, upon irradiation with IR light, undergo an intermolecular [2+2] cycloaddition reaction through coumarin units through the coumarin components of different units of said coumarin-polymer conjugate thereby forming a crosslinked product, compositions/mixtures comprising said conjugates, products comprising the crosslinked product, and uses thereof. The new coumarin-polymer conjugates of the invention are particularly useful for 3D bioprinting.

Resumen de: US2023166455A1

A bioprinter (1) comprising at least one printhead (4a, 4b, 4c) with nozzle (5), a printbed (20) onto which the printhead (4a, 4b, 4c) is arranged to print an ink, an ultrasonic sensor arrangement arranged at the printbed (20), a controller (7) arranged to control movement of the printhead/nozzle (4a, 4b, 4c; 5) and to perform calibration of the printhead/nozzle (4a, 4b, 5 4c; 5) based on information from the ultrasonic sensor arrangement.

Resumen de: US2023170116A1

The present invention relates to a method of fabricating a programmable and/or reprogrammable magnetic soft device having a Young's modulus of less than 500 MPa in a part of the device. The invention further relates to an untethered programmable and/or reprogrammable, in particular 3D, magnetic soft device having a part with Young's modulus of less than 500 MP, to a method of encoding a programmable and/or reprogrammable magnetic soft device, and to a use of a programmable and/or reprogrammable magnetic soft device.

Resumen de: AU2023202961A1

A system for creating cranial remolding orthoses comprises a controller in data communication with an additive fabricator and a scanner. The controller has access to a database of mappings of nonstandard cranial shapes to desired cranial shapes, to cranial scan data for a patient with an existing cranium shape, and to patient-specific information about the patient. The controller has design software for determining from the scan data a development path from the existing cranium shape to a desired cranium shape, the development path comprising a plurality of development path stages. Fabrication software in the controller allows it to instruct the fabricator for fabricating a cranial remodeling orthoses corresponding to the development path without requiring a physical model. The othoses comprise a monolithic hollow core shell of thickness varying according to the desired remodeling of the cranium, an inner soft liner, and a fastener disposed for mounting the orthoses on the cranium of the patient.

Resumen de: AU2021365763A1

An additive manifold includes a valve side including a plurality of valve mounts; and a tube fitting side including a plurality of integrally formed tube fittings. The additive manifold includes at least one passageway formed between the valve side and the tube fitting side, the at least one passageway allowing fluid communication between the valve mounts and the tube fittings.

Resumen de: AU2021363120A1

An electrostimulatable 3-dimensional (3D) electrogel scaffold comprising piezoelectric nanoparticles uniformly dispersed throughout a homogenous hydrogel polymer matrix, wherein the hydrogel polymer matrix is gelled and comprises crosslinked alginate, carboxymethyl-chitosan and agarose polymers.

Resumen de: WO2023097074A1

Printed delivery devices are disclosed herein. The printed delivery devices may include a layer formed from a water-soluble, printable composition. The water-soluble, printable composition may include purified water, pullulan, and vegetable glycerin. The printed delivery device may also include a support substrate made from polyester and/or polyolefin. The first layer may be printed on the support substrate.

Resumen de: WO2023096876A2

Implementations describe systems and methods for manufacturing and performing quality assessment of dental appliances. In one embodiment, a method of manufacturing a dental appliance comprises receiving, at a holder, a feature of the dental appliance, the feature comprising a first surface having a first shape, wherein the holder holds the feature of the dental appliance at a reference position. The method further includes automatically placing an object against the feature at the reference position using a robot arm, wherein the object comprises a second surface having a second shape that mates with the first shape. The method further includes applying pressure to press the object against the feature of the dental appliance and bonding the object to the feature of the dental appliance while applying the pressure.

Resumen de: WO2023094565A1

The present invention relates to a printing apparatus for additive manufacturing methods, comprising: one or more print heads (1, 2), which each comprise a printing nozzle, the print head or print heads being optionally vertically movable; and a print bed which has a print table that is movable in a horizontal direction and optionally in a vertical direction and comprises a printing surface (3), the print table having an optical device (4) which is designed to capture an optical reproduction of the printing nozzle or printing nozzles at least from below. The invention also relates to a method comprising automatic position calibration of the printing nozzle(s) for the additive manufacturing of objects, preferably pharmaceutical administration forms, using the apparatus according to the invention.

Resumen de: WO2023094585A1

The invention relates to a method for producing a medical product, comprising the following step: a) additively building or manufacturing at least one functional element on a surface of a base body, the at least one functional element being connected to the base body after carrying out step a). The invention also relates to a medical product (1) produced by the method.

Resumen de: WO2023094655A1

The invention relates to a medical device (1) for delivering a therapeutic agent by bio-printing, comprising a rod body (2) comprising - a bio-printing cartridge (4) arranged in proximity to the distal end of the rod body (2), comprising: - an upper layer comprising a solution comprising a therapeutic agent; and - an absorbent compound capable of converting the light energy of laser radiation into thermal energy and arranged in such a way as to cause heating of the solution comprising a therapeutic agent, so as to produce a jet of the solution; - an optical fibre (3) extending longitudinally inside a lumen of the rod body (2) in order to convey a laser flux to the absorbent compound.

Resumen de: US2023166011A1

The present invention relates to an animal model with ischemic heart disease, by a 3-dimensional bioprinted occluder and method for producing the same.

Resumen de: WO2023095467A1

Provided is a 3D printing composition comprising: a first (meth)acrylate having a urethane bond; a second (meth)acrylate having a poly-conjugated diene structure and a urethane bond; and a mono-functional third (meth)acrylate having a glass transition temperature Tg of 70ºC or higher.

Resumen de: WO2023096331A1

The present invention relates to an orthodontic sheet having a composite structure by stacking and binding different materials, the orthodontic sheet comprising a first sheet layer, a second sheet layer, and an intermediate sheet layer formed between the first sheet layer and the second sheet layer, wherein the intermediate sheet layer comprises: a bead portion formed of a hard material in comparison to the first sheet layer and the second sheet layer and formed in a bead structure; and a binding portion for binding the first sheet layer and the second sheet layer due to the materials of the first sheet layer and the second sheet layer being filled between the beads of the bead portion.

Resumen de: WO2023096327A1

The present invention relates to an orthodontic sheet having a composite structure by stacking and binding different materials, the orthodontic sheet comprising a first sheet layer, a second sheet layer, and an intermediate sheet layer formed between the first sheet layer and the second sheet layer, wherein the intermediate sheet layer comprises: a mat portion formed of a hard material in comparison to the first sheet layer and the second sheet layer and formed in a mesh structure; and a binding portion for binding the first sheet layer and the second sheet layer due to the materials of the first sheet layer and the second sheet layer being filled in the meshes of the mat portion.