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Resultados 57 resultados LastUpdate Última actualización 03/10/2022 [13:23:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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Live salmonella typhi vectors engineered to express protein antigens and methods of use thereof

NºPublicación: AU2021230603A1 29/09/2022

Solicitante:

UNIVERSITY OF MARYLAND BALTIMORE
NAT RES COUNCIL CANADA

WO_2021178891_A1

Resumen de: AU2021230603A1

The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live

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NK-LYSIN PEPTIDE COMPOSITIONS AND METHODS FOR THEIR USE AS ANTIMICROBIAL/ANTIVIRAL AGENTS

NºPublicación: US2022305093A1 29/09/2022

Solicitante:

UNIV KING ABDULAZIZ [SA]

US_11260113_B1

Resumen de: US2022305093A1

Natural killer (NK)-lysin peptides from chicken, bovine and human species are used as an antimicrobial or antiviral agent alone or in combination with other agents. A pharmaceutical composition comprising NK-lysin peptides was effective against Rotavirus and various gram-negative and gram-positive bacteria that were tested. Combinations of NK-lysin peptides plus silver nanoparticles or IL-2 were also effective against Salmonella typhimurium. Treatment with the NK-lysin peptides repressed β-lactam-resistance genes (CTX-M-1, CTX-M-8 and CTX-M-9) in bacterial species tested and thus can be used to augment treatment with β-lactams and increase bacterial sensitivity to this important class of antibiotics.

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Live salmonella typhi vectors engineered to express cancer protein antigens and methods of use thereof

NºPublicación: AU2021230602A1 29/09/2022

Solicitante:

UNIVERSITY OF MARYLAND BALTIMORE
IRAZU BIO LLC

WO_2021178888_A1

Resumen de: AU2021230602A1

The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live

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METHODS AND COMPOSITIONS FOR USE OF RECOMBINANT BACTERIAL EFFECTOR PROTEINS AS ANTI-INFLAMMATORY AGENTS

NºPublicación: US2022306702A1 29/09/2022

Solicitante:

WISTAR INST [US]
INNATE BIOLOGICS LLC [US]

US_2021054033_A1

Resumen de: US2022306702A1

A method of obtaining a population of cells enriched in human polymorphonuclear myeloid derived suppressor cells (PMN-MDSCs) comprises isolating from a cell suspension those cells which express LOX-1 to provide a population of cells enriched with PMN-MDSCs. A method of monitoring the population of LOX-1+ cells in a cell-containing biological sample is useful for determining the efficacy of treatment or the metastasis or increasing progression of cancer. Other cell isolation and diagnostic methods are also described. A composition for use in diagnosing and treating cancer related to PMN-MDSC is provided that contains antagonists and/or inhibitors of genes related to the ER stress response.

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DOSAGE AND ADMINISTRATION OF A BACTERIAL SACCHARIDE GLYCOCONJUGATE VACCINE

NºPublicación: EP4061412A1 28/09/2022

Solicitante:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

BR_112022008761_A2

Resumen de: WO2021099982A1

The present invention provides a glycoconjugate for administration to a subject in a method comprising the steps of: (i) administering a first dose of glycoconjugate; (ii) subsequently administering a second dose of glycoconjugate; wherein the amount of glycoconjugate in the first dose or first and second doses are atypically low, and also related aspects.

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一种体外原核表达肠道沙门氏菌avrA蛋白的方法

NºPublicación: CN115093469A 23/09/2022

Solicitante:

江苏农林职业技术学院

Resumen de: CN115093469A

本发明公开了一种体外原核表达肠道沙门氏菌avrA蛋白的方法。本发明所述的方法包括以下步骤:(S1)设计沙门氏菌的avrA基因的引物,进行avrA基因体外扩增;(S2)重组载体的构建:将扩增后的avrA基因与通过BamH I酶切位点和XhoI酶切位点双酶切后的pGEX‑4T‑1质粒大片段进行重组,得到重组载体pGEX‑4T‑1‑avrA质粒;(S3)重组菌的构建:将步骤(S2)得到的重组载体转化进感受态细胞中;所述的感受态细胞分别为BL21和Rosetta 2表达菌种;(S4)avrA蛋白的诱导表达:将步骤(S3)得到的重组菌在培养基中培养,将适当浓度的IPTG加入培养基中,诱导avrA蛋白表达。本发明实现了avrA蛋白在细菌裂解上清液中表达,使avrA蛋白的活性及功能更接近原始状态。

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METHODS FOR IDENTIFYING NOVEL DOSING REGIMENS

NºPublicación: JP2022137084A 21/09/2022

Solicitante:

ザヴァンテセラペウティクス,インコーポレイテッド

CN_111787924_A

Resumen de: WO2018129560A1

The present invention provides for methods of treating a Gram negative bacterial infection comprising a co-administration regimen of an effective amount of fosfomycin together with at least one antimicrobial agent selected from the group consisting of piperacillin-tazobactam, ceftazidime and meropenem to an infected subject. The present invention further provides for a method of treating a subject with a bacterial infection that includes infection with a "resistant" mutant subpopulation selected from the group consisting of Staphylococcus aureus, Enterococcus faecalis, Pseudomonas aeruginosa, Acinetobacter baumannii and E. coli, the method comprising (a) obtaining a sample from a subject suffering from a bacterial infection; (b) identifying the presence of the "resistant" mutant subpopulation in said sample; and (c) co-administering fosfomycin and at least one antimicrobial agent to the subject, wherein after the co-administration, the bacterial density is effectively reduced and the "resistant" mutant subpopulation is inhibited.

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一种沙门氏菌马流产活疫苗的制备方法

NºPublicación: CN115058360A 16/09/2022

Solicitante:

重庆澳龙生物制品有限公司

Resumen de: CN115058360A

本发明提供了一种沙门氏菌马流产活疫苗的制备方法,属于兽用疫苗制备技术领域。包括:将马流产沙门氏菌C355弱毒菌接种于普通琼脂斜面上进行斜面培养,得到一级种子;将一级种子接种于沙门氏菌液体培养基中进行二级种子培养,得到二级种子;将二级种子接种于沙门氏菌液体培养基中进行发酵,得到发酵液,收集所述发酵液中的沙门氏菌;将得到的沙门氏菌与冻干保护剂混合,得到沙门氏菌马流产活疫苗。采用本发明的制备方法制备疫苗周期短、生产强度小,安全性和免疫性要优于原生产工艺。

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DETECTION OF THE INHIBITION CAPACITY OF A FIRST MICROBIAL STRAIN ON THE GAS PRODUCTION OF A SECOND GAS PRODUCING MICROBIAL STRAIN

NºPublicación: US2022290206A1 15/09/2022

Solicitante:

CHR HANSEN AS [DK]

BR_112022002254_PA

Resumen de: US2022290206A1

The present invention relates to a method for quantifying the inhibition capacity of at least one, potentially inhibiting, first bacterial or yeast strain towards a gas producing, potentially undesirable, second bacterial or yeast strain, based on a measure of the total gas production. Examples of a first bacterial or yeast strain are probiotic bacterial strains of the genus Bacillus, Lactobacillus or Lactococcus, and examples of the gas producing bacterial or yeast strain are bacteria such as Clostridium, fusobacteria, Escherichia coli and Salmonella or yeast such as Saccharomyces or Pichia.

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METHODS OF INCREASING VACCINE EFFICACY

NºPublicación: US2022288198A1 15/09/2022

Solicitante:

GENOME PROT INC [US]

CN_114502573_PA

Resumen de: US2022288198A1

The present invention relates, in part, to compositions and methods for enhancement of an immune response and for increased vaccine efficacy by stimulation of the TLR5 receptor, for example, with a recombinant TLR5 agonist (e.g., a flagellin-based agent or variant thereof).

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ENGINEERED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF

NºPublicación: US2022280577A1 08/09/2022

Solicitante:

ACTYM THERAPEUTICS INC [US]

JP_2021530220_A

Resumen de: US2022280577A1

Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella, or by modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin− and/or pagP−. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd−, purI−, and msbB−. The immunostimulatory bacteria, such as Salmonella species, are modified to encode immunostimulatory proteins that confer anti-tumor activity in the tumor microenvironment, and/or are modified so that the bacteria preferentially infect immune cells in the tumor microenvironment, or tumor-resident immune cells, and/or are modified to induce less cell death in immune cells than in other cells. Also provided are methods of inhibiting the growth or reducing the volume of a solid tumor by administering the immunostimulatory bacteria.

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TUMOR-TARGETING SALMONELLA GALLINARUM STRAIN AND USE THEREOF

NºPublicación: EP4053283A1 07/09/2022

Solicitante:

UNIV NAT CHONNAM IND FOUND [KR]

KR_20210052337_A

Resumen de: EP4053283A1

The present invention relates to a tumor-targeting Salmonella gallinarum strain and the use thereof. The tumor-targeting Salmonella gallinarum strain has excellent tumor proliferation inhibitory activity and enables tumor-specific targeting, and thus can be utilized for treatment and imaging of tumors without any side effects.

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IMMUNOGENIC CONJUGATES AND USE THEREOF

NºPublicación: JP2022130637A 06/09/2022

Solicitante:

グラクソスミスクラインバイオロジカルズソシエテアノニム

JP_2019535775_A

Resumen de: WO2018096007A2

The provided technology is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to antigens to form nOMV-antigen conjugates, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates is also provided.

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一种含有能表达痢疾志贺氏菌O抗原的脂多糖的沙门菌、制备方法及其应用

NºPublicación: CN114990042A 02/09/2022

Solicitante:

南昌大学

Resumen de: CN114990042A

本发明公开了一种能表达痢疾志贺氏菌O抗原的脂多糖的沙门菌,该菌能够将痢疾志贺氏菌O抗原的脂多糖表达在重组沙门菌的外膜囊泡上,沙门菌通过基因改造去掉沙门菌自身O抗原;去掉干扰沙门菌外膜囊泡免疫反应的FliC和FljB鞭毛蛋白;去掉沙门菌自身非必须的外膜蛋白OmpA、OmpC和OmpD。本发明还公开了所述菌在制备抗痢疾志贺氏菌疫苗中的应用。

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KIT FOR PREDICTING OR DIAGNOSING NONALCOHOLIC FATTY LIVER DISEASE, AND METHOD FOR DIAGNOSING NONALCOHOLIC FATTY LIVER DISEASE

NºPublicación: US2022276246A1 01/09/2022

Solicitante:

KOBIOLABS INC [KR]

US_2022257669_A1

Resumen de: US2022276246A1

The present invention relates to a kit for predicting or diagnosing the degree of risk of disease, a method for providing information for predicting or diagnosing the degree of risk of disease, a method for screening a therapeutic agent of disease, and a pharmaceutical composition for prevention or treatment of disease, for nonalcoholic fatty liver disease. Specifically, through the kit for predicting or diagnosing of the present invention, the degree of risk of nonalcoholic fatty liver disease can be effectively predicted or diagnosed, and in particular, the predictive value and significance of information provision in non-obese subjects are excellent. Therefore, by providing effective information on nonalcoholic fatty liver disease through this, it can be effectively used to prevent or treat the corresponding disease. In addition, the pharmaceutical composition for prevention or treatment of the present invention may be effectively used for treatment of nonalcoholic fatty liver disease.

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SALMONELLA TYPHI DETECTION KIT, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

NºPublicación: WO2022179494A1 01/09/2022

Solicitante:

WANG WEIJIA [CN]
YUAN YONG [CN]

CN_113249499_A

Resumen de: WO2022179494A1

A salmonella typhi detection kit, a preparation method therefor and an application thereof. The detection kit comprises an amplification primer, crRNA, an LbCas12a-RR protein and a single-stranded DNA reporting system. The crRNA is a specific crRNA for a detection section of a flag gene of the salmonella typhi. The sequence expressed by the LbCas12a-RR protein is a sequence obtained by carrying out prokaryotic codon optimization on a Cas12 protein nucleic acid sequence and respectively mutating the 532nd and 595th amino acids into G532R and K595R. The detection kit for the salmonella typhi is used for nucleic acid detection of the salmonella typhi.

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Novel PD-L1 Targeting DNA Vaccine for Cancer Immunotherapy

NºPublicación: US2022273782A1 01/09/2022

Solicitante:

VAXIMM AG [CH]

BR_112019019251_A2

Resumen de: US2022273782A1

The present invention relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding PD-L1. In particular, the present invention relates to said attenuated strain of Salmonella for use in the treatment of cancer.

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ANTIBODIES TO TIGIT

NºPublicación: JP2022126847A 30/08/2022

Solicitante:

ジェイエヌバイオサイエンシーズエルエルシー

KR_20220024837_PA

Resumen de: WO2017152088A1

The invention provides monoclonal antibodies that specifically bind to TIGIT. The monoclonal antibodies have the capacity for substantial activation of T cells and natural killer cells by inhibiting binding of TIGIT to CD 155. The monoclonal antibodies can be used for treatment of cancer and infectious disease, among other applications.

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Endophytic bacillus from Pu'er tea tree leaves and application thereof

NºPublicación: AU2020418980A1 25/08/2022

Solicitante:

UNIV SOUTH CHINA TECH

WO_2021135544_A1

Resumen de: AU2020418980A1

An endophytic bacillus from Pu'er tea tree leaves and an application thereof. The endophytic bacillus from Pu'er tea tree leaves is named Bacillus velezensis FZ06, and was deposited at the China Center for Type Culture Collection in Wuhan University, Wuhan, China on 25 October 2019, with deposit number CCTCC NO: M 2019854. The bacterium can produce lipopeptide substances, including 27 species in three categories, with a higher richness than other previously reported Bacillus velezensis. The lipopeptides produced have obvious inhibitory activity on pathogenic bacteria such as Escherichia coli, Staphylococcus aureus, Salmonella, Aspergillus flavus, and Aspergillus parasiticus, and can be used to inhibit pathogenic bacteria.

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ANTIBODY MOLECULE-DRUG CONJUGATES AND USES THEREOF

NºPublicación: US2022267418A1 25/08/2022

Solicitante:

VISTERRA INC [US]

AU_2022200567_A1

Resumen de: US2022267418A1

Antibody molecule-drug conjugates (ADCs) that specifically bind to lipopolysaccharides (LPS) are disclosed. The antibody molecule-drug conjugates can be used to treat, prevent, and/or diagnose bacterial infections and related disorders.

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Avian food additive

NºPublicación: GB2604026A 24/08/2022

Solicitante:

PEPSIS LTD [GB]

WO_2022136889_A1

Resumen de: GB2604026A

Feed additive for an avian granivore comprising a malt extract comprising one or more enzymes selected from amylases, maltases, cellulases, fructanases, glucanases, xylanases, and deacetylases. The feed additive is used for: treating/preventing one or more pathogenic bacteria, e.g gastrointestinal pathogenic bacteria such as Escherichia coli, Salmonella enteritidis, Campylobacter spp, and Staphylococcus spp, with or without the combination of a further antibiotic; reducing viral infections; reducing post-race recovery time for Columba livia domestica; improving energy utilisation, improving voluntary feed intake; increasing egg weight; increasing eggshell thickness; improving feed conversion ratio; and increasing the firmness of avian granivore droppings. The malt extract may additionally comprise: proteinases; lipases; and water soluble sugars selected from maltose, maltotriose, and maltose polymers. The malt extract may be based on the seeds of barley, wheat, triticale, sorghum, maize, buck wheat, and rice. The feed additive may additionally comprise: medium chain triglycerides e.g. coconut oil; water soluble organic acids or salts thereof e.g. caprylic acid, sorbic acid, caproic acid, benzoic acid, ascorbic acid, propionic acid, acetic acid, formic acid, fumaric acid, tartaric acid. The feed additive may be used in combination with granivore feed and the avian granivore may be Columba livia domestica or Gallus gallus domestica.

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COMPOSITIONS AND METHODS FOR PRODUCING ENHANCED IMMUNE RESPONSES AND RAPID ANTIBODY PRODUCTION

NºPublicación: EP4045672A1 24/08/2022

Solicitante:

UNIV VIRGINIA PATENT FOUNDATION [US]

WO_2021076897_A1

Resumen de: WO2021076897A1

Provided are modified bacteria and derivatives thereof that express antigens of interest. In some embodiments, the bacterium has a reduced genome and induces an enhanced immune response against the antigen of interest when administered to a subject as compared to an immune response that would have been induced by a bacterium of the same strain that has a full complement of genes. In some embodiments, the antigen is expressed on a surface of a bacterium. Also provided are method for producing antibody against antigens of interest, vaccine compositions, methods for vaccinating subjects, methods for treating cancers in subjects, methods for modulating inappropriate and undesirable immune response, methods for targeting materials in or on a human or animal that may be the cause of disease or otherwise undesirable phenotypes, and expression vectors for expressing antigens on the surface of reduced genome bacteria.

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NOVEL VACCINE COMPOSITIONS

NºPublicación: EP4045079A1 24/08/2022

Solicitante:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

BR_112022006549_A2

Resumen de: EP3808372A1

A Shigella flexneri O-antigen of a first serotype or subserotype for use in raising an immune response against one or more Shigella flexneri O-antigen of a different serotype or subserotype, together with associated binding moieties, pharmaceutical compositions, kits, uses or methods.

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INTRACELLULAR DELIVERY OF THERAPEUTIC PROTEINS DESIGNED TO INVADE AND AUTONOMOUSLY LYSE AND METHODS OF USE THEREOF

NºPublicación: WO2022174226A1 18/08/2022

Solicitante:

UNIV MASSACHUSETTS [US]
ERNEST PHARMACEUTICALS LLC [US]

WO_2022174224_PA

Resumen de: WO2022174226A1

Provided herein is a bacterial delivery platform that harnesses mechanisms unique to Salmonella to intracellularly deliver protein-based drugs.

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COMPOSITION AND METHOD FOR PREVENTING, ALLEVIATING, OR TREATING LIVER INJURY

Nº publicación: US2022257669A1 18/08/2022

Solicitante:

KOBIOLABS INC [KR]

US_2022276246_PA

Resumen de: US2022257669A1

The present invention relates to a composition for preventing, alleviating or treating liver injury, for example, nonalcoholic fatty liver, and more specifically, it relates to a composition for preventing or treating liver injury comprising a Ruminococcus spp. strain.

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