SALMONELLA

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Resultados 67 results. LastUpdate Updated on 18/06/2021 [21:22:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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IL-12 IMMUNOCONJUGATE

Publication No.: EP3834847A1 16/06/2021

Applicant:

PHILOGEN SPA [IT]

ES_2706428_T3

Absstract of: EP3834847A1

Conjugate comprising interleukin-12 (IL-12) and a single chain targeting portion comprising two antigen binding sites. The targeting portion may comprise an antibody fragment such as a single chain diabody. The conjugate may be a single chain fusion protein. Use of single chain bivalent IL-12 immunocytokine for targeting the extra-cellular matrix (ECM) of tissues, particularly tumour neovasculature antigens, for example fibronectin. Use for treating cancer or pathological angiogenesis in a patient.

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POLYPEPTIDES SELF-ASSEMBLING INTO NANOPARTICLES

Publication No.: EP3833676A1 16/06/2021

Applicant:

ETH ZUERICH [CH]

US_2021163540_A1

Absstract of: WO2020030654A1

The present invention relates to polypeptides self-assembling into nanoparticles. In particular, the invention relates to a polypeptide comprising an amino acid sequence I (SEQ ID NO: 1), a nucleic acid sequence encoding said polypeptide, a nanoparticle comprising at least one polypeptide of the invention, a complex comprising said nanoparticle and one or more cargo molecules, and a method for transfecting a cell with said complex.

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MILLETTIA SPECIOSA POLYSACCHARIDES, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF IN ANTIBACTERIAL ASPECTS

Publication No.: WO2021109714A1 10/06/2021

Applicant:

UNIV SOUTH CHINA TECH [CN]

CN_110903409_A

Absstract of: WO2021109714A1

Disclosed are Millettia speciosa polysaccharides, a preparation method therefor and an application thereof in antibacterial aspects. The method comprises the following steps: (1) cleaning, slicing, drying, smashing and sieving Millettia speciosa root pieces, and then performing hot water reflux extraction to obtain a crude extract of Millettia speciosa polysaccharides; (2) depigmenting the crude extract of the Millettia speciosa polysaccharides by using macroporous resin, removing residual protein by using a Sevag reagent, and then performing alcohol precipitation to obtain crude Millettia speciosa polysaccharides; (3) adding the crude Millettia speciosa polysaccharides to water to prepare a crude Millettia speciosa polysaccharide solution, and then adding same to a DEAE-52 cellulose anion exchange column, eluting by using distilled water and 0.2 mol/L of a NaCl solution successively, and collecting eluates separately to obtain Millettia speciosa polysaccharides MSCP1 and MSCP2. The Millettia speciosa polysaccharides prepared in the present invention have a certain inhibitory effect on Gram-negative bacteria, especially Escherichia coli and Salmonella. Therefore, the Millettia speciosa polysaccharides can be used to develop antibacterial materials or antibacterial agents.

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USE OF MYRICETIN IN THE PREPARATION OF SALMONELLA TYPE Ⅲ SECRETION SYSTEM INHIBITOR

Publication No.: WO2021109924A1 10/06/2021

Applicant:

UNIV JILIN [CN]

CN_110859832_A

Absstract of: WO2021109924A1

The present invention relates to the use of myricetin in the preparation of a salmonella type III secretion system inhibitor. Human cervical cancer cells (HeLa) are used as the infection carrier. In vivo and in vitro experiments confirm that myricetin inhibits the function of a type III secretion system, and so has a significant inhibitory effect on salmonella infections. Compared with the action mechanism of traditional antibiotics in directly killing salmonella, the traditional Chinese medicine compound myricetin can directly inhibit the function of salmonella type III secretion system, thereby exerting an anti-infection effect, which gives bacteria a small selective pressure and does not easily induce the emergence of bacteria drug resistance, and has the characteristics of wide sources, low cost and high cure rate.

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IMMUNOGENIC ANTI-INFLAMMATORY COMPOSITIONS

Publication No.: JP2021088568A 10/06/2021

Applicant:

クーバイオロジックスインク.QUBIOLOGICSINC.

JP_2019070040_A

Absstract of: CA2804709A1

The invention provides methods of formulating an anti-inflammatory composition for treating inflammatory conditions in a specific organ or tissue. The method involves selecting at least one pathogen that is pathogenic in the specific organ or tissue; producing an antigenic composition comprising antigenic determinants that together are specific for the pathogen; and formulating the antigenic composition for administration as an anti-inflammatory composition capable of eliciting an anti-inflammatory response in the specific organ or tissue, wherein the condition characterized by inflammation is not a cancer. In embodiments of the invention, a cancer is situated in the specific organ or tissue.

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USE OF TOLL-LIKE RECEPTOR AGONIST FOR TREATING CANCER

Publication No.: US2021169972A1 10/06/2021

Applicant:

CLEVELAND BIOLABS INC [US]

US_2019275128_A1

Absstract of: US2021169972A1

The present invention is directed to methods and agents used for treating cancer in Toll-Like Receptor 5-expressing tissues by providing a Toll-Like Receptor agonist such as flagellin. The present invention also relates to protecting the liver from a liver toxicity using a Toll-like receptor agonist.

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MDR E. COLI SPECIFIC ANTIBODY

Publication No.: US2021162034A1 03/06/2021

Applicant:

X4 PHARMACEUTICALS AUSTRIA GMBH [AT]

JP_2019068841_A

Absstract of: US2021162034A1

The subject relates to an isolated antibody that specifically binds to O25b antigen of multi drug resistant (MDR) E. coli strains, its medical and diagnostic use, method of producing the antibody, including an isolated nucleotide sequence, plasmids and host cells as used in the production of the antibody; and further an isolated epitope recognized the specific antibody.

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BURKHOLDERIA PSEUDOMALLEI COMPLEX OUTER MEMBRANE VESICLES AS ADJUVANTS

Publication No.: US2021162033A1 03/06/2021

Applicant:

ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND [US]

KR_20200142028_A

Absstract of: US2021162033A1

Outer membrane vesicles from bacteria of the Burkholderia pseudomallei complex can be 5 used as adjuvants in compositions and methods to potentiate the immune response to immunogens.

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QUALITATIVE METHOD AND KIT FOR THE COLORIMETRIC DETECTION OF SALMONELLA FOR SURFACES BASED ON GOLD NANOPARTICLES AND APTAMERS, AND AN APTASENSOR COMPRISING SAME

Publication No.: WO2021102546A1 03/06/2021

Applicant:

TNS NANOTECNOLOGIA LTDA [BR]

Absstract of: WO2021102546A1

The present invention relates to a qualitative method and kit for the colorimetric detection of Salmonella for surfaces based on gold nanoparticles and aptamers, and an Aptasensor comprising same for a novel qualitative method of colorimetric detection of Salmonella contamination in surface samples using gold nanoparticles and aptamers. In particular, the invention provides highly sensitive and specific bifunctional oligonucleotide probes that can be used for detecting Salmonella in samples containing interferents, such as food supply chain surface samples. The invention also anticipates a detection kit and a method involving same for detecting Salmonella. The invention also provides two sequences of probes functionalized with the thiol group for detecting Salmonella contamination. In another important aspect of the invention, an aptasensor is provided containing a gold nanoparticle and a main aptamer which is bound by means of probes complementary to the sequence of the main aptamer. Detection is carried out in surface samples based on a change in colour.

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USE OF 3, 4-DIARYLPYRAZOLES AS ANTIBACTERIAL AGENTS

Publication No.: EP3827825A1 02/06/2021

Applicant:

UNIV WAGENINGEN [NL]

Absstract of: EP3827825A1

The use of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof as an antibacterial or antibioticagainst Staphylococcus, Escherichia, Streptococcus, Klebsiella, Mycobacterium, Pseudomonas, Clostridium, Acinetobacter, Enterococcus, Pasteurella Bacillus anthracis. Listeria monocytogenes, Corynebacterium diphtheriae, Salmonella, Shigella, Moraxella, Helicobacter, Legionella, Vibrio, Rickettsia, Neisseria, Actinobacter, is disclosed.

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DE-IMMUNIZED SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES FOR APPLICATIONS IN MAMMALS

Publication No.: CN112851769A 28/05/2021

Applicant:

分子模板公司

AU_2021200390_A1

Absstract of: CN106103489A

The present invention is directed to T-cell epitope delivering polypeptides which deliver one or more CD 8+ T-cell epitopes to the MHC class I presentation pathway of a cell, including toxin- derived polypeptides which comprise embedded T-cell epitopes and are de-immunized. The present invention provides cell-targeted, CD8+ T-cell epitope delivering molecules for the targeted delivery of cytotoxicity to certain cells, e.g., infected or malignant cells, for the targeted killing of specific cell types, and the treatment of a variety of diseases, disorders, and conditions, including cancers, immune disorders, and microbial infections. The present invention also provides methods of generating polypeptides capabl e of delivering one or more heterologous T-cell epitopes to the MHC class I presentation pathway, including polypeptides which are 1 ) B-cell and/or CD4+ T-cell de-immunized, 2) comprise embedded T-cell epitopes, and/or 3) comprises toxin effectors which retain toxin functions.

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ENGINEERED MICROBE-TARGETING MOLECULES AND USES THEREOF

Publication No.: US2021155677A1 27/05/2021

Applicant:

HARVARD COLLEGE [US]

JP_2020128421_A

Absstract of: US2021155677A1

Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. Some particular embodiments of the microbe-targeting or microbe-binding molecules comprise a carbohydrate recognition domain of mannose-binding lectin, or a fragment thereof, linked to a portion of a Fc region. In some embodiments, the microbe-targeting molecules or microbe-binding molecules can be conjugated to a substrate, e.g., a magnetic microbead, forming a microbe-targeting substrate (e.g., a microbe-targeting magnetic microbead). Such microbe-targeting molecules and/or substrates and the kits comprising the same can bind and/or capture of a microbe and/or microbial matter thereof, and can thus be used in various applications, e.g., diagnosis and/or treatment of an infection caused by microbes such as sepsis in a subject or any environmental surface. Microbe-targeting molecules and/or substrates can be regenerated after use by washing with a low pH buffer or buffer in which calcium is insoluble.

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A NEW ANTIBIOTIC SELECTIVELY KILLS GRAM-NEGATIVE PATHOGENS

Publication No.: WO2021098989A1 27/05/2021

Applicant:

UNIV JUSTUS LIEBIG GIESSEN [DE]

Absstract of: WO2021098989A1

The invention is concerning a medical preparation comprising bicyclic heptapeptides for use in vertebrates or humans suffering from an infection caused by Gramnegative bacteria like Pseudomonas aeruginosa, Klebsiella pneumoniae, Acineto bacter baumannii, Neisseria gonorrhoeae, Chlamydia trachomatis, Shigella sonnei, Salmonella enterica Typhimurium LT2, Enterobacter spp., Bifidobacterium longum, Bacteroides fragilis, Lactobacillus reuteri, Enterococcus spp., Yersinia pestis and numerous other Gram-negative bacteria.

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CELL-PENETRATING BACTERIAL E3-UBIQITIN-LIGASES FOR USE IN IMMUNOTHERAPY

Publication No.: AU2021202654A1 27/05/2021

Applicant:

UNIV MUENSTER WESTFAELISCHE WILHELMS

US_2020038493_A1

Absstract of: AU2021202654A1

Abstract The present invention relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bac-teria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for use in immunotherapy. The present invention further relates to cell-penetrating effector proteins of type III secretion system (T3SS)-containing bacteria of the genus Salmonella or Shigella and variants, fragments and immunmodulatory domains thereof, for delivering cargo molecules into eukaryotic cells.

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Bacteria-Based Protein Delivery

Publication No.: US2021155942A1 27/05/2021

Applicant:

UNIV BASEL [CH]

JP_2020182478_A

Absstract of: US2021155942A1

The present invention relates to recombinant Gram-negative bacterial strains and the use thereof for delivery of heterologous proteins into eukaryotic cells.

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AMES NEGATIVE SUBLIMATION TONER

Publication No.: US2021157250A1 27/05/2021

Applicant:

ESPRIX TECH LP [US]

Absstract of: US2021157250A1

Provided are toners and combinations of toners that demonstrate excellent color and are Ames test negative in both Salmonella typhimurium strains TA98 and TA100.

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DIAGNOSTIC KIT AND METHOD FOR THE SIMULTANEOUS DETECTION OF A COMBINATION OF MULTIPLE GRAM-POSITIVE BACTERIA AND/OR GRAM-NEGATIVE BACTERIA

Publication No.: EP3825422A2 26/05/2021

Applicant:

SIGMA ALIMENTOS SA DE CV [MX]

MX_2018008742_A

Absstract of: EP3825422A2

A method for the simultaneous detection of a combination of multiple Gram-positive bacteria and/or Gram-negative bacteria in a sample, the method comprising: providing DNA extracted from the sample; preparing a reaction mixture containing the DNA, one or more pairs of oligonucleotide primers having a sequence selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO: 2, SEQ ID NO: 4 and SEQ ID NO: 5, SEQ ID NO: 7 and SEQ ID NO: 8, SEQ ID NO: 10 and SEQ ID NO: 11, SEQ ID NO: 13 and SEQ ID NO: 14, SEQ ID NO: 16 and SEQ ID NO: 17 and combinations of same, and one or more oligonucleotide probes having a sequence selected from the group consisting of SEQ ID NO: 3, SEQ ID NO: 6, SEQ ID NO: 9, SEQ ID NO: 12, SEQ ID NO: 15, SEQ ID NO: 18 and combinations of same; amplifying the DNA included in the reaction mixture, by means real-time polymerase chain reaction; and simultaneously determining the presence or absence of Gram-positive bacteria and/or Gram-negative bacteria in the sample. The method can be used to identify any combination of three species of Gram-positive bacteria (Listeria ssp., Listeria monocytogenes and Staphylococcus aureus) and three species of Gram-negative bacteria (Escherichia coli spp., Escherichia coli O157:H7 and Salmonella spp.).

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Automated priming and library loading device

Publication No.: GB2589159A 26/05/2021

Applicant:

CLEAR LABS INC [US]

US_2020251181_A1

Absstract of: GB2589159A

Provided herein are methods and apparatus for the identification of pathogenic and non-pathogenic microorganisms in food and environmental samples. The disclosure solves existing challenges encountered in identifying food borne pathogens, including pathogens of the Salmonella, Campylobacter, Listeria, and Escherichia genera in a timely and efficient manner. The disclosure also provides methods for differentiating a transient versus a resident pathogen, correlating presence of non-pathogenic with pathogenic microorganisms, distinguishing live versus dead microorganisms by sequencing.

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METHOD FOR INCREASING ETEC CS6 ANTIGEN PRESENTATION ON CELL SURFACE AND PRODUCTS OBTAINABLE THEREOF

Publication No.: US2021147491A1 20/05/2021

Applicant:

SCANDINAVIAN BIOPHARMA HOLDING AB [SE]

US_2019389913_A1

Absstract of: US2021147491A1

A method for increase the presentation of ETEC CS6 antigen on a cell surface, comprising the step of contacting cells expressing said antigen with an aqueous solution comprising 0.6-2.2 percent phenol by weight, such that the presentation of said antigen is increased by at least 100%. A method for the manufacture of a killed whole cell vaccine for immunization against CS6-expressing ETEC. Cells and vaccines obtainable by the above methods.

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METHOD OF REDUCING EGG CONTAMINATION

Publication No.: US2021145954A1 20/05/2021

Applicant:

UNIV GENT [BE]

PE_20190225_A1

Absstract of: US2021145954A1

The present invention relates to Salmonella mutant strains and their use as a vaccine for preventing Salmonella infection, in particular in eggs.

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ENGINEERED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF

Publication No.: EP3820992A2 19/05/2021

Applicant:

ACTYM THERAPEUTICS INC [US]

CN_112673092_A

Absstract of: WO2020014543A2

Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella or modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin- and/or pagP -. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd -, purI - and msbB -. The immunostimulatory bacteria, such as Salmonella species, are modified to encode immunostimulatory proteins that confer anti-tumor activity in the tumor microenvironment, and/or are modified so that the bacteria preferentially infect immune cells in the tumor microenvironment or tumor-resident immune cells and/or induce less cell death in immune cells than in other cells. Also provided are methods of inhibiting the growth or reducing the volume of a solid tumor by administering the immunostimulatory bacteria.

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ERADICATION OF BACTERIAL BIOFILM USING ANTI-AMYLOID MONOCLONAL ANTIBODIES

Publication No.: CN112805296A 14/05/2021

Applicant:

英联邦高等教育系统天普大学兰肯瑙医学研究所

US_2021122809_A1

Absstract of: WO2019226978A1

The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.

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GLYCOCONJUGATE VACCINES COMPRISING BASIC UNITS OF A MOLECULAR CONSTRUCT EXPRESSING BUILT-IN MULTIPLE EPITOPES FOR THE FORMULATION OF A BROAD-SPECTRUM VACCINE AGAINST INFECTIONS DUE TO ENTEROPATHOGENIC BACTERIA

Publication No.: US2021138059A1 13/05/2021

Applicant:

BIOSYNTH SRL [IT]

Absstract of: US2021138059A1

The present invention refers to new glycoconjugate antigens expressing built-in multiple epitopes and to polyvalent glycoconjugate vaccines intended for the protection of mammalians, and particularly for the protection of the human population from enteropathogenic bacteria, such as the Gram-positive anaerobic bacterium Clostridium difficile and the Gram-negative bacteria Salmonella typhi, Escherichia Coli, Vibrio Cholerae, Shigella flexneri, Salmonella typhimurium, Salmonella enteritidis, Salmonella paratyphi A, Shigella sonnei, Shigella dysenteriae, Salmonella cholerasuis, Klebsiella, Enterobacter, Pseudomonas aeruginosa and/or from viral gastrointestinal infections due to human noroviruses.

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SYSTEMS AND METHODS FOR DETECTING INFECTIOUS DISEASES

Publication No.: BR112016004994A2 11/05/2021

Applicant:

THERANOS IP CO LLC [US]
THERANOS INC [US]

US_2020234804_A1

Absstract of: US2015072338A1

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (POS) location and may be tested at the POS location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may be determined by the condition or past history of a subject. Test results may be obtained within a short amount of time after sample placement in a testing device, or within a short amount of time after being obtained from the subject. A prescription for treatment of a detected disorder may be provided, and may be filled, at the POS location. A bill may be automatically generated for the testing, or for the prescription, may be automatically sent to an insurance provider, and payment may be automatically obtained.

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TUMOR-TARGETING SALMONELLA GALLINARUM STRAIN AND USE THEREOF

Nº publicación: KR20210052337A 10/05/2021

Applicant:

CHOYBIOLAB CO LTD [KR]

WO_2021086085_A1

Absstract of: WO2021086085A1

The present invention relates to a tumor-targeting Salmonella gallinarum strain and the use thereof. The tumor-targeting Salmonella gallinarum strain has excellent tumor proliferation inhibitory activity and enables tumor-specific targeting, and thus can be utilized for treatment and imaging of tumors without any side effects.

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