SALMONELLA

VolverGo back

Resultados 111 results. LastUpdate Updated on 27/05/2023 [13:28:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



previousPage Page2/5 nextPage   results/page


AUTOTRANSPORTER SYSTEM

Publication No.: EP4168554A1 26/04/2023

Applicant:

PROKARIUM LTD [GB]

CN_116113705_PA

Absstract of: WO2021255480A1

The present invention provides for a modified autotransporter and the use of genetically engineered microorganisms comprising said modified autotransporters in the treatment of infectious and neoplastic disease. The present invention therefore also relates to vaccine and immunotherapeutic compositions comprising said genetically engineered microorganism.

traducir

SHIGELLA-TETRAVALENT (SHIGELLA4V) BIOCONJUGATE

Publication No.: EP4168040A1 26/04/2023

Applicant:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

BR_112022024294_PA

Absstract of: WO2021255684A1

A composition comprising Shigella-Tetravalent (4-valent Shigella) bioconjugates. That encompasses the Shigella O-polysaccharide antigens of serotypes Shigella flexneri 2a, 3a, 6 and Shigella sonnei covalently linked to the protein carrier.

traducir

APPARATUS AND METHOD FOR INACTIVATING VIRUSES AND PATHOGENS IN HUMAN PLASMA UNITS

Publication No.: WO2023063933A1 20/04/2023

Applicant:

CASTOR TREVOR P [US]

Absstract of: WO2023063933A1

The present invention is a physical pathogen reduction method and apparatus for controlling or eliminating transfusion-transmittable infections. This purely physical technique does not involve the use of heat, chemicals and/or irradiation, each of which has significant drawbacks in the pathogen reduction of human plasma, The invention inactivates both nonenveloped and enveloped viruses as well as pathogenic bacteria and parasites in units of human plasma, while retaining the natural biological activity, integrity and potency of the treated plasma. The method uses critical, near-critical or supercritical fluids for viral and pathogen reduction of units of donor blood plasma, using novel blood plasma bags. The apparatus is in the form of a bench-top or mobile transportable unit, which can be used in hospitals, blood banks, medical facilities and hot zones in developing countries for the clearance of viruses from human plasma.

traducir

VACCINE AGAINST KLEBSIELLA PNEUMONIAE

Publication No.: US2023122752A1 20/04/2023

Applicant:

IDORSIA PHARMACEUTICALS LTD [CH]

US_2021198304_A1

Absstract of: US2023122752A1

The present invention relates to a synthetic saccharide of general formula (I) that is related to Klebsiella pneumoniae serotype O1, O2, O2ac, and O8 O-polysaccharide and carbapenem-resistant Klebsiella pneumoniae ST258 O-polysaccharide and conjugate thereof. Said synthetic saccharide, said conjugate and pharmaceutical composition containing said synthetic saccharide or said conjugate are useful for prevention and/or treatment of diseases associated with Klebsiella pneumoniae. Furthermore, the synthetic saccharide of general formula (I) is useful as marker in immunological assays for detection of antibodies against Klebsiella pneumoniae bacteria.

traducir

MICROBIAL COMPOSITIONS AND USES THEREOF

Publication No.: US2023123485A1 20/04/2023

Applicant:

SUPERBREWED FOOD INC [DE]

Absstract of: US2023123485A1

Provided are microbial compositions comprising at least one attenuated form of a pathogenic bacterium having an ability to colonize at least one organ of the gastrointestinal tract of an animal, such as an attenuated form of a bacterium having an antagonistic effect against a bacterium selected from the group consisting of Salmonella enteritidis, Salmonella enterica, Salmonella typhimurium, lostridium difficile, Clostridium perfringens, Escherichia coli, Campylobacter spp., Listeria monocytogenes, Yersinia enterocolitica and combinations thereof. Also provided are animal feeds comprising such compositions, preparations for in-ovo injection comprising such compositions and methods of treatment using such compositions.

traducir

SALMONELLA-BASED DNA VACCINES IN COMBINATION WITH AN ANTIBIOTIC

Publication No.: US2023121528A1 20/04/2023

Applicant:

VAXIMM AG [CH]

JP_2023510770_A

Absstract of: US2023121528A1

The present invention relates to a Salmonella typhi Ty21a strain comprising a DNA molecule comprising at least one eukaryotic expression cassette encoding at least one tumor antigen, stroma antigen and/or checkpoint inhibitor antigen for the use in the treatment of cancer in a human subject following treatment with an antibiotic, wherein the Salmonellatyphi Ty21a strain is to be administered orally and optionally in combination with a checkpoint inhibitor.

traducir

LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS CANCER PROTEIN ANTIGENS AND METHODS OF USE THEREOF

Publication No.: JP2023516420A 19/04/2023

Applicant:

ユニヴァーシティーオブメリーランドバルチモア

AU_2021230602_PA

Absstract of: WO2021178888A1

The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector, wherein the Salmonella Typhi vector has been engineered to express one or more cancer antigens. In some aspects the vector has been engineered to express an outer membrane folding protein Bam A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella Typhi vector is capable of delivering the antigen to a mucosal tissue or subcutaneously to dendritic cells via an outer membrane vesicle when administered to a subject.

traducir

LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS PROTEIN ANTIGENS AND METHODS OF USE THEREOF

Publication No.: JP2023516397A 19/04/2023

Applicant:

ユニヴァーシティーオブメリーランドバルチモア

US_2023104907_PA

Absstract of: WO2021178891A1

The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector, wherein the Salmonella Typhi vector has been engineered to express one or more antigens; an outer membrane folding protein Bam A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella Typhi vector is capable of delivering the antigen to a mucosal tissue via an outer membrane vesicle when administered to a subject.

traducir

PRO-INFLAMMATORY AND ADJUVANT FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS

Publication No.: JP2023055883A 18/04/2023

Applicant:

ザチルドレンズメディカルセンターコーポレーション

JP_2023055880_PA

Absstract of: WO2016115097A2

The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.

traducir

PRO-INFLAMMATORY AND ADJUVANT FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS

Publication No.: JP2023055880A 18/04/2023

Applicant:

ザチルドレンズメディカルセンターコーポレーション

JP_2023055883_PA

Absstract of: WO2016115097A2

The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.

traducir

BACTERIA-BASED PROTEIN DELIVERY

Publication No.: CN115960919A 14/04/2023

Applicant:

巴塞尔大学

KR_20220127345_PA

Absstract of: US2017198297A1

The present invention relates to recombinant Gram-negative bacterial strains and the use thereof for delivery of heterologous proteins into eukaryotic cells.

traducir

MULTI-SENSORY ENRICHMENT WITH SELF-ADMINISTERING HEALTH PRODUCT DELIVERY SYSTEM

Publication No.: WO2023060081A1 13/04/2023

Applicant:

UNIV TEXAS TECH SYSTEM [US]

US_2023105761_PA

Absstract of: WO2023060081A1

The present disclosure describes a self-sprayer device for self-administering an animal product to an animal and providing environmental enrichment to the animal.

traducir

MICROORGANISM IDENTIFICATION METHOD

Publication No.: CN115927528A 07/04/2023

Applicant:

株式会社岛津制作所学校法人名城大学

US_2019242903_A1

Absstract of: WO2017168742A1

This microorganism identification method comprises: a step in which a sample containing microorganisms is subjected to mass spectrometry and a mass spectrum is obtained; a reading step in which the mass-to-charge ratio m/z of peaks derived from a marker protein is read from the mass spectrum; and an identification step in which the mass-to-charge ratio m/z is used as a basis to identify whether the microorganisms included in the sample include any bacterial species from among Escherichia coli, bacteria of the genus Shigella, and Escherichia albertii. The microorganism identification method is characterized in that at least one of the following thirteen types of ribosomal proteins is used as the marker protein: S5; L15; S13; L31; L22; L19; L20; L13; S15; L25; HNS; HdeB; and L29.

traducir

MULTI-SENSORY ENRICHMENT WITH SELF-ADMINISTERING HEALTH PRODUCT DELIVERY SYSTEM

Publication No.: US2023105761A1 06/04/2023

Applicant:

UNIV TEXAS TECH SYSTEM [US]

WO_2023060081_PA

Absstract of: US2023105761A1

The present disclosure describes a self-sprayer device for self-administering an animal product to an animal and providing environmental enrichment to the animal.

traducir

LIVE SALMONELLA TYPHI VECTORS ENGINEERED TO EXPRESS PROTEIN ANTIGENS AND METHODS OF USE THEREOF

Publication No.: US2023104907A1 06/04/2023

Applicant:

UNIV MARYLAND [US]
NAT RES COUNCIL CANADA [CA]

JP_2023516397_A

Absstract of: US2023104907A1

The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella typhi vector, wherein the Salmonella typhi vector has been engineered to express one or more antigens; an outer membrane folding protein Barn A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella typhi vector is capable of delivering the antigen to a mucosal tissue via an outer membrane vesicle when administered to a subject.

traducir

STRUCTURALLY MODIFIED CHIMERIC POLYPEPTIDE OF HUMAN PAPILLOMAVIRUS, RECOMBINANT PROTEIN COMPRISING SAME POLYPEPTIDE, AND USE OF SAME PROTEIN

Publication No.: EP4159746A1 05/04/2023

Applicant:

GENEMATRIX INC [KR]

AU_2021281910_PA

Absstract of: EP4159746A1

The present invention relates to a chimeric recombinant protein having a therapeutic effect on cervical cancer by fusing genetic modified E6 and E7, which are carcinogenesis-inducing proteins of human papillomavirus high-risk group type 16, with a fusion protein for increasing immunogenicity, the HPV type 16 E6, E7 chimeric recombinant protein fused with the flagellin fusion protein of the present invention showed the lowest tumor cell volume, and the immune response of specific T cells according to the recombinant antigen was significantly confirmed, and when the prophylactic effect was measured, it was confirmed that the volume of tumor cells was low and the antibody titer was increased, therefore human papillomavirus recombinant antigen of the present invention shows tumor treatment and prophylaxis and can be applied as a therapeutic/prophylactic vaccine composition.

traducir

Salmonella strain for treating cancer and use thereof

Publication No.: CN115916981A 04/04/2023

Applicant:

全南国立大学校产学协力团

AU_2020454144_PA

Absstract of: KR102327091B1

The present invention relates to a Salmonella strain selectively acting on cancer to treat cancer and a composition for preventing or treating cancer, comprising the same. Specifically, the Salmonella strain according to the present invention has a tumor-suppressing effect, and has remarkably low viability in a normal organ, thereby having a remarkable anticancer effect compared to the conventional inventions.

traducir

Method for double-target detection of drug-resistant salmonella based on RPA-Cas12a

Publication No.: CN115873930A 31/03/2023

Applicant:

YANGZHOU FOOD AND DRUG INSPECTION AND TESTING CENTER

Absstract of: CN115873930A

The invention discloses a double-target detection method for drug-resistant salmonella based on RPA-Cas12a, which comprises the following steps: culturing the drug-resistant salmonella overnight, cleaning, heating, cracking, centrifugally extracting supernatant, placing a DNA (deoxyribonucleic acid) extracting solution, RPA (recombinase polymerase amplification) freeze-dried powder, a primer and a buffer solution required by RPA amplification at the bottom of an Ep tube with a tube cover, and temporarily storing a Cas12a detection solution in the tube cover; then, the Ep tube is flatly placed, and after amplification, Cas12a detection liquid in a tube cover flows to the tube bottom in a transient centrifugation mode and is mixed with amplification liquid at the tube bottom; and after the Ep tube is continuously incubated for a period of time, carrying out fluorescence detection on a reaction product. The Cas12a is placed in the cover of the Ep tube, after RPA in the Ep tube reacts, the Cas12a is added in a centrifugal mode, salmonella detection can be achieved in a short time, the detection sensitivity is high, operation is more convenient, and cross contamination between samples is avoided.

traducir

Salmonella drug resistance detection device

Publication No.: CN115873704A 31/03/2023

Applicant:

SHANDONG ACAD OF AGRICULTURAL SCIENCES

Absstract of: CN115873704A

The salmonella drug resistance detection device comprises a box body and a bearing disc used for bearing drug sensitive paper sheets, and a positioning mechanism used for positioning the bearing disc and a grabbing mechanism used for grabbing the drug sensitive paper sheets on the bearing disc to a culture dish are arranged in the box body; during an experiment, the drug sensitive paper sheets are placed on the bearing plates, the plurality of bearing plates are positioned through the positioning mechanism, the grabbing mechanism grabs the drug sensitive paper sheets into the culture dish, the drug sensitive paper sheets can be automatically attached to the surface of a culture medium, manual clamping is not needed, the experiment efficiency is improved, and the pollution risk is reduced.

traducir

INDEL MOLECULAR MARKER OF ULTRASONIC MUTAGENESIS SALMONELLA TYPHIMURIUM HISD GENE AND USE THEREOF

Publication No.: EP4155414A1 29/03/2023

Applicant:

UNIV JIANGSU [CN]

GB_2612409_PA

Absstract of: EP4155414A1

The present disclosure provides an insertion and deletion (InDel) molecular marker of a hisD gene of ultrasonically-mutagenized Salmonella typhimurium (S. typhimurium) and use thereof, and belongs to the field of molecular biology. In the present disclosure, through ultrasonic mutagenesis to S. typhimurium and sequencing, it is found that all InDel mutations occur in a core mutation region of the hisD gene. Therefore, the core mutation region is used as the InDel molecular marker to determine an insertion or a deletion of a gene reverse mutation, and the InDel molecular marker can also be used to analyze a relationship between a sequence of the hisD gene and a function of a protein encoded thereby.

traducir

Antigen protein and application thereof

Publication No.: CN115850407A 28/03/2023

Applicant:

UNIV SHIHEZI

Absstract of: CN115850407A

The invention belongs to the technical field of germ detection, and particularly relates to an antigen protein and application thereof, and the antigen protein is suitable for salmonella pullorum detection. The antigen protein comprises a sequence as shown in SEQIDNO.1 or SEQIDNO.2, the antigen protein has very strong specificity to salmonella pullorum antibodies, the salmonella pullorum is detected by an indirect ELISA (Enzyme-Linked Immunosorbent Assay) method taking the two antigen proteins as coating antigens, the minimum positive serum dilution ratio can reach 1: 1600, and the sensitivity is high; in addition, the intra-batch repetition variable coefficient and the inter-batch repetition variable coefficient are both lower than 10%, and repeatability is good.

traducir

Salmonella gallinarum attenuated isolates not expressing Peg pilus and application of salmonella gallinarum attenuated isolates

Publication No.: CN115851771A 28/03/2023

Applicant:

UNIV YANGZHOU

Absstract of: CN115851771A

The invention discloses a salmonella gallinarum attenuated isolated strain not expressing Peg mycosis and application of the salmonella gallinarum attenuated isolated strain. The isolated strain is orally inoculated with an SGOP strain with the dose of 1 * 10 < 10 > CFU and has no pathogenicity to SPF chickens of 1 day age, the SGOP strain is immunized and inoculated to the SPF chickens of 1 day age, chicken flocks immunized with the SGOP strain can resist toxic attack of salmonella gallinarum wild strain U20 after 21 days, and 70% of chicken flocks attacked with toxic attack are protected without diseases. The SGOP strain disclosed by the invention is relatively high in safety, does not influence the monitoring and purification procedures of avian salmonella, and has relatively great potential in clinical prevention and control of salmonella gallinarum infection and marker attenuated vaccine candidate strains thereof.

traducir

Multiplex PCR (Polymerase Chain Reaction) detection primer combination for bacteria and application thereof

Publication No.: CN115851988A 28/03/2023

Applicant:

BEIJING HFK BIO TECH CO LTD

Absstract of: CN115851988A

The invention relates to the technical field of microbiological detection, and particularly discloses a multiple PCR detection primer combination for bacteria and application thereof, and the multiple PCR detection primer combination for bacteria comprises primer combinations for performing multiple PCR detection on pseudomonas aeruginosa, staphylococcus aureus, klebsiella pneumoniae, proteus mirabilis, helicobacter and salmonella respectively. The invention also provides a multiple PCR detection kit for bacteria and a multiple PCR detection method for bacteria. The detection primer combination disclosed by the invention has good sensitivity and specificity, is matched with an optimized amplification system and program, so that the amplification efficiency is remarkably improved, the result is accurate, the efficiency is high, the consumed time is short, the damage to animals can be avoided, and the detection primer combination has a practical application value.

traducir

Preparation method of kit for detecting salmonella typhimurium and kit

Publication No.: CN115856297A 28/03/2023

Applicant:

UNIV JILIN

Absstract of: CN115856297A

The invention provides a preparation method of a kit for detecting salmonella typhimurium and the kit, and belongs to the technical field of kits. The preparation method comprises the following steps: firstly, preparing magnetic beads with superparamagnetism, coating the magnetic beads serving as a magnetic core with an organic covalent skeleton (COF) to form a core-shell structure, namely MCOF nano magnetic particles, and then loading gold nanoparticles on the MCOF nano magnetic particles by using an in-situ reduction method, so as to obtain the MCOF nano magnetic particles. And finally, coupling with an aptamer of salmonella typhimurium to synthesize the nano probe apt-MCOF-AuNPs with high fluorescence emission. The salmonella typhimurium and the nanoprobe are co-incubated to form a probe-thallus compound, a quenching agent Fe < 3 + > is added to quench fluorescence of the probe, the fluorescence of the probe cannot be quenched by the Fe < 3 + > due to the protective effect of thallus on the nanoprobe and competitive binding of the thallus and the Fe < 3 + >, and the solution is bright green fluorescence under irradiation of 365 nm ultraviolet light. Therefore, rapid and specific detection of salmonella typhimurium is realized.

traducir

Traditional Chinese veterinary medicine'replacement resistance 'compound preparation as well as preparation method and application thereof

Nº publicación: CN115844955A 28/03/2023

Applicant:

UNIV SOUTHWEST JIAOTONG

Absstract of: CN115844955A

The invention belongs to the technical field of traditional Chinese veterinary medicines, and particularly relates to a traditional Chinese veterinary medicine'alternative resistance 'compound preparation as well as a preparation method and application thereof. The traditional Chinese veterinary medicine'anti-replacement 'compound preparation is prepared from the following raw materials in parts by weight: 10 to 20 parts of flos lonicerae extract, 20 to 40 parts of macleaya cordata extract, 10 to 20 parts of radix scutellariae extract, 10 to 20 parts of radix astragali seu hedysari extract, 5 to 20 parts of herba lysimachiae extract and 5 to 20 parts of cassia twig extract. The traditional Chinese veterinary medicine'anti-replacement 'compound preparation provided by the invention can effectively prevent common pathogenic bacteria such as escherichia coli, staphylococcus aureus, salmonella and pasteurella in the chicken breeding process. The method has important research value in the field of traditional Chinese veterinary medicines, improves the green breeding level of China, and ensures food safety.

traducir

previousPage Page2/5 nextPage results/page

punteroimgGo back