Absstract of: WO2023003329A1

The present invention relates to a vaccine composition comprising a capsular polysaccharide-protein conjugate derived from Salmonella typhi, wherein the optimal culture conditions for Salmonella typhi growth and Vi capsular polysaccharide expression were established, the purified Vi capsular polysaccharide was conjugated to a conjugate protein to produce a conjugate having a specific average molecular weight, and it was confirmed that a Vi capsular polysaccharide-conjugated protein conjugate of the present invention had excellent immunogenicity. A method for producing the Vi capsular polysaccharide-conjugated protein conjugate of the present invention, and a conjugate produced thereby can be used for the prevention of typhoid.

Absstract of: WO2021099982A1

The present invention provides a glycoconjugate for administration to a subject in a method comprising the steps of: (i) administering a first dose of glycoconjugate; (ii) subsequently administering a second dose of glycoconjugate; wherein the amount of glycoconjugate in the first dose or first and second doses are atypically low, and also related aspects.

Absstract of: KR20230011851A

전이금속 디칼코게나이드 기반 인공 항체로서, 전이금속 디칼코게나이드(TMD) 나노시트; 및 상기 나노시트에 형성된 고분자상(polymeric phase를 포함하는 것을 특징으로 하는 전이금속 디칼코게나이드 기반 인공 항체가 제공된다.

Absstract of: WO2018096013A1

The provided technology is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to antigens to form nOMV-linker-antigen conjugates, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates is also provided.

Absstract of: AU2022204265A1

A sensing chip with fluidic device includes a substrate with a first area and a second area, a field effect transistor is arranged in the second area of the substrate and is electrically connected with the field effect transistor. The fluidic device includes an insulation layer with a window to expose the surface of substrate in the second area. A second gate electrode is arranged in the window of the isolation layer on the second area of the substrate. The sample is placed in the fluidic device to contact with the second gate electrode, and the receptor(s) on the metal layer will capture the target object in the sample, so the voltage of the metal layer will change with amount of the target object captured by the receptor(s). Thus, the concentration of the target object(s) in the sample may obtain by the changes of the voltage of the metal layer. 3 0 50 4010 206 m-40214 lOB 1OA Fig.lIA

Absstract of: WO2023287770A2

Described herein are engineered Salmonella Typhimurium (S. Typhimurium) bacteria and uses thereof. In some embodiments, the engineered S. Typhimurium bacteria comprises an exogenous collagenase. Also described in exemplary embodiments herein methods of using the engineered S. Typhimurium bacteria, such as part of a cancer therapy.

Absstract of: WO2021178891A1

The present invention provides compositions and methods of inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector, wherein the Salmonella Typhi vector has been engineered to express one or more antigens; an outer membrane folding protein Bam A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella Typhi vector is capable of delivering the antigen to a mucosal tissue via an outer membrane vesicle when administered to a subject.

Absstract of: WO2021178888A1

The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live Salmonella Typhi vector, wherein the Salmonella Typhi vector has been engineered to express one or more cancer antigens. In some aspects the vector has been engineered to express an outer membrane folding protein Bam A or a fragment or variant thereof; and a lipid A deacylase PagL or a fragment or variant thereof, wherein the Salmonella Typhi vector is capable of delivering the antigen to a mucosal tissue or subcutaneously to dendritic cells via an outer membrane vesicle when administered to a subject.

Absstract of: WO2018035394A1

Ingestible devices configured to obtain samples when present in the GI tract of a subject, as well as related systems and methods, are disclosed. Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are also disclosed.

Absstract of: AU2021267035A1

Formulations of egg powders with avian antibodies that act as mucosal protectants are provided. The formulations are effective for protecting the mucosal membranes in the pharyngeal area of an individual from viral infections. Formulations effective for reducing infections of SARS-CoV-2 in individuals are provided. Formulations are also effective for reducing transmission of viral disease. The formulations are tablets, candies, gummies, throat lozenges, and powders for administering to the pharyngeal area. Methods for administering the formulations for reducing viral disease such as Covid-19 are disclosed.

Absstract of: EP4111865A1

The invention corresponds to an antibacterial formulation comprising a mixture of bacteriophages having lytic activity against strains of Salmonella spp. and a pharmaceutically and veterinarily acceptable vehicle, pH stabilizer and/or excipients. This formulation is for the prevention and treatment of infectious diseases caused by Salmonella spp. and different serovars; use and method for preventing or treating infectious diseases caused by Salmonella spp. in farm animals because it comprises administering the antibacterial formulation to a non-human animal orally.

Absstract of: CN115558701A

The invention discloses a method for evaluating chlorine resistance of avian salmonella and application of the method. The method comprises the following steps: step 1, preparing a bacterial suspension; step 2, preparing a chlorine disinfectant; 3, chlorine resistance is measured and evaluated. According to the method for evaluating the chlorine resistance of the poultry-derived salmonella and the application of the method, the chlorine resistance strength of the to-be-detected strain can be rapidly and accurately evaluated, and the antibiotics which have cross drug resistance to the to-be-detected strain with the chlorine resistance can be screened out, so that the edible safety of poultry is improved.

Absstract of: CN115554441A

The invention relates to the technical field of disinfection equipment, and discloses an innovative purification and disinfection equipment system which comprises a tap water outlet bin system, a disinfection water reaction bin system, a water pump system, a disinfection safety door spraying system, a sewage recovery system and a sewage treatment system, the tap water outlet bin system is mainly used for storing tap water in advance according to the actual goods quantity and disinfection requirements, and the tap water is generally stored according to the ton level; the disinfection water reaction bin system internally comprises a diamond film electrode module, a reaction bin indicator light module, a visual reverse bin, an intelligent control screen, a water tank and a structure protection module. According to the innovative purification and disinfection equipment system, bacterial viruses such as escherichia coli, staphylococcus aureus, salmonella typhimurium and new coronavirus can be easily disinfected, the disinfection time is short, the disinfection efficiency is improved, and the innovative purification and disinfection equipment system is free of corrosion and stimulation, friendly to people, free of harm to human bodies and free of corrosion to metal surfaces.

Absstract of: CN115558648A

The invention discloses two anti-bacterial pilus monoclonal antibodies, a hybridoma cell strain and application of the hybridoma cell strain. The invention discloses a simple and rapid preparation method of an anti-bacterial pilus monoclonal antibody, an immunogen is a target antigen recombination strain S9H-F18ab for expressing escherichia coli F18 pilus or a target antigen recombination strain S9H-Peg for expressing salmonella Peg pilus on the surface of a thallus, the preparation method is simple, and the method is suitable for large-scale production. Antigen extraction, expression and purification are not needed, an adjuvant does not need to be added during antigen immune injection, the number of immunization times is small, and the time is short; in the screening process of the hybridoma cells, the hybridoma cells capable of secreting the escherichia coli F18 fimbriae agglutination antibody or the hybridoma cells capable of secreting the salmonella Peg fimbriae agglutination antibody can be conveniently and quickly screened out by utilizing a glass plate agglutination experiment instead of utilizing ELISA (Enzyme-Linked Immunosorbent Assay). The method provided by the invention can be used for simply, conveniently and efficiently preparing the monoclonal antibody aiming at the specific antigen target and the application of the monoclonal antibody.

Absstract of: WO2022270953A1

The present invention relates to a Salmonella typhimurium strain having YjeK gene deleted therefrom and to uses thereof. More specifically, the present invention relates to: a novel Salmonella typhimurium strain; and a vaccine composition, an immunogenic composition, and a feed composition comprising same. It was confirmed that the Salmonella typhimurium strain having YjeK gene deleted therefrom according to the present invention can effectively prevent Salmonella infection, thereby remarkably increasing a survival rate of an individual. This means that when the Salmonella typhimurium strain having YjeK gene deleted therefrom of the present invention is used as a vaccine, diseases related to Salmonella infection can be effectively prevented such that the present invention can be used in various ways in the field of livestock disease control.

Absstract of: CN115531481A

The invention provides a composition for treating salmonellosis of red-feather pullorum as well as a preparation method and application of the composition, and belongs to the technical field of poultry disease prevention and treatment. The traditional Chinese medicine composition for treating pullorum salmonellosis comprises humifuse euphorbia herb, fructus chebulae, bighead atractylodes rhizome, folium isatidis, garlic and liquorice. Aiming at the disease types of pullorum disease and dyspnea of the red-feather chickens, the invention provides a traditional Chinese medicine composition which takes humifuse euphorbia herb and myrobalan as monarch drugs to clear heat, stop diarrhea and astringe lung to arrest cough, takes folium isatidis and garlic as minister drugs to enhance the heat-clearing and detoxifying effects of the monarch drugs, takes bighead atractylodes rhizome as assistant drugs to tonify qi, invigorate spleen, eliminate dampness and promote urination, and takes liquorice as guide drugs to harmonize the drugs. According to the present invention, the formula is reasonable, the monarch drug, the minister drug, the assistant drug and the guide drug are combined to produce the synergistic effect, the obvious inhibition effect on the red-feather pullorum disease salmonella is provided, the pullorum disease and dyspnea symptoms are reduced, the red-feather pullorum disease incidence is reduced, the survival rate is improved, the meat quality of the red-feather chicken

Absstract of: WO2022270953A1

The present invention relates to a Salmonella typhimurium strain having YjeK gene deleted therefrom and to uses thereof. More specifically, the present invention relates to: a novel Salmonella typhimurium strain; and a vaccine composition, an immunogenic composition, and a feed composition comprising same. It was confirmed that the Salmonella typhimurium strain having YjeK gene deleted therefrom according to the present invention can effectively prevent Salmonella infection, thereby remarkably increasing a survival rate of an individual. This means that when the Salmonella typhimurium strain having YjeK gene deleted therefrom of the present invention is used as a vaccine, diseases related to Salmonella infection can be effectively prevented such that the present invention can be used in various ways in the field of livestock disease control.

Absstract of: EP4109086A1

A sensing chip with fluidic device (1) includes a substrate (10) with a first area (10A) and a second area (10B), a second gate electrode (40) is arranged in the second area of the substrate and is electrically connected with the field effect transistor (20). The fluidic device includes an insulation layer (30) with a window (302) to expose the surface of substrate in the second area. A second gate electrode is arranged in the window of the isolation layer on the second area of the substrate. The sample is placed in the fluidic device to contact with the second gate electrode, and the receptor(s) on the metal layer will capture the target object in the sample, so the voltage of the metal layer will change with amount of the target object captured by the receptor(s). Thus, the concentration of the target object(s) in the sample may obtain by the changes of the voltage of the metal layer.

Absstract of: WO2021167996A1

The present disclosure provides immunogenic compositions comprising Group A Streptococcus (GAS) polypeptide antigens and at least one polypeptide-polysaccharide conjugate. The present disclosure further provides methods of using such compositions to induce immune responses against GAS infections in subjects.

Absstract of: CN115521536A

The invention belongs to the technical field of plastics, particularly relates to a preparation process of an antibacterial plastic color master batch formula, and aims to solve the problems of poor antibacterial property and low antibacterial rate in the prior art. The material comprises 55-65 parts of a main material, 5-10 parts of antibacterial ceramic microparticles, 5-10 parts of antibacterial montmorillonite, 1-5 parts of a nano antibacterial agent, 10-15 parts of toner, 1-5 parts of a dispersing agent and 1-5 parts of an oxidizing agent, and the antibacterial ceramic microparticles comprise ceramic microparticles, ceramic glaze, silver-loaded silicate and zinc oxide. According to the antibacterial plastic color master batch, various antibacterial materials in the antibacterial plastic color master batch are utilized, so that the antibacterial ability of the antibacterial plastic color master batch is greatly enhanced, the antibacterial rate on escherichia coli, tritirachium album, salmonella and staphylococcus is increased, mould breeding can be prevented, and long-term storage of the antibacterial plastic color master batch is facilitated.