CORONAVIRUS: DIAGNOSIS AND THERAPY IN HUMANS

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Resultados 207 results. LastUpdate Updated on 18/06/2021 [19:36:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 120 días/Published applications in the last 120 days



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METHOD AND KIT FOR DETECTION OF POLYNUCLEOTIDE

Publication No.: WO2021111466A1 10/06/2021

Applicant:

COUNCIL SCIENT IND RES [IN]

Absstract of: WO2021111466A1

The invention describes a kit for detection of a target polynucleotide using a CRISPR effector system that comprises CAS9 from Francisella novicida, a synthetic sgRNA and a detection scheme based on binding and subsequent enzymatic cleavage of the target polynucleotide. The invention also describes a method for detection of a target polynucleotide using the kit. The kit can be applied to both pathogenic and non-pathogenic polynucleotides and can be used to distinguish polynucleotides different by a single mismatch without the need for sequencing. The kit can also be used for detection of COVID-19. The kit is economical, easy to assemble and provides a robust and rapid readout that can be appropriately adapted for point of care applications.

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ANTI VI ANTIVIRAL SHOPPING CART HANDLES

Publication No.: AU2021101829A4 10/06/2021

Applicant:

THOMAS ALAN JOHN [AU]

Absstract of: AU2021101829A4

DESCRIPTION OF THE INVENTION 1 / The AntiVi Invention is an attachable metal handle that is attached each end by a screw or bolt to the handle section of a shopping trolley.The handle is encased in any printing required and has a PVC antiviralplastic sleeve permanently attached to the handle by a compressed air systemAs shown in Page 6 Claims.These new antiviral handles can be exchanged with existing cart handles. 2 /The AntiVi Invention has antibacterial qualities but the main thrust of the protection is antiviral which is extremely important with the Covid 19 virus prevalent throughout the world.The AndVi invention is based on Silver Ions which is a powerful antimicrobial agent and the US E.PA has found it inhibits the growth of Covid 19 virus. 3 / The size of the metal handles can vary- but can be in the range of 40-70 cm. Length with a diameter in the range 15-50 mmthe PVC antiviral sleeves are made to suit the handles length. Thickness of the PVC antiviral film can be between 1 and 2 mm.As shown in ernails from Jackty at Coaction they can grind the antimicrobial additive finely to suit the thickness of the PVC sleeves-which shows their willingness to help make our Invention program successful. 4 / How PVC film is made from a Google site The electrolysis of salt water produces chlorine which is then combined with Ethylene that has been obtained from oilThe resulting element is Ethylene Di Chloride which converts at very high temperature to Vinyl Chloride Monomer.These Mon

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Methods of Treating Cytokine Storm Infections, Including COVID-19, By Inhibiting CCR5/CCL5 (RANTES) Interaction, and Compositions for Practicing the Same

Publication No.: US2021171646A1 10/06/2021

Applicant:

INCELLDX INC [US]

US_2021032355_A1

Absstract of: US2021171646A1

Methods of treating a subject suffering from COVID-19 are provided. Aspects of the methods including administering to the subject an effective amount of an inhibitor of CCR5/CCL5 interaction, such as a CCR5 antagonist. Also provided are methods of assessing severity of a disease involving hypercytokinemia, such as COVID-19, by determining the level of CCL5/RANTES in a subject, as well as compositions for use in such methods.

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Half-life optimized linker composition

Publication No.: US11028132B1 08/06/2021

Applicant:

ROSEN YITZHAK [US]

Absstract of: US11028132B1

Coronavirus disease 2019 (COVID-19 or COVID-2) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Common symptoms include fever, cough, and shortness of breath. The virus is mainly spread during close contact and via respiratory droplets produced when people cough or sneeze. Respiratory droplets may be produced during breathing but the virus is not generally airborne. A half-life optimized fusion composition linked by a Half-Life Optimizing (H-Lo) linker comprising of a receptor binding domain (RBD), a half-life extending domain (LED), wherein the LED is any one of a monoclonal antibody, single domain antibody, nanobody, antibody fragment, or combination thereof and the H-Lo linker with an X+7 amino acid length fusing the RBD C-terminus with the LED N-terminus (RBD-LED fusion) is discussed in the invention.

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Electrochemical device for virus detection and treatment

Publication No.: US11026664B1 08/06/2021

Applicant:

PETROVIC SLOBODAN [US]

Absstract of: US11026664B1

Viruses, including corona viruses such as COVID-19, are often present in the mouth or nose of a person before they infect the body. The disclosed electrochemical device destroys or denatures viruses in the mouth or nose rendering the viruses ineffective to cause infection by applying a low voltage potential to the mucus. The device has a potentiostat powered by a small battery embedded in a plastic frame that fits in a person's mouth. The device has electrodes to contact the mucus of the mouth or nose. The mucus serves as electrolyte, conducting ions as well as viruses with their protein “skin” towards the electrode. The viruses are adsorbed onto the metal probes where the electrical current denatures the protein skin of the virus rendering the virus ineffective to cause infection.

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Anti-SARS-CoV-2 antibodies derived from 2DD8

Publication No.: US11028150B1 08/06/2021

Applicant:

CENTIVAX INC [US]

Absstract of: US11028150B1

This disclosure provides antibodies and antigen-binding fragments that are derived from 2dd8 and that can be administered to an individual that is infected or suspected of being infected with a virus. Antibodies and antigen-binding fragments herein can be capable of treating or curing the virus, and which may provide protection against the virus for up to several weeks. Antibodies and antigen-binding fragments herein can be used to diagnose a SARS CoV-2 infection.

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Therapy for viral infections including the novel corona virus (COVID-19)

Publication No.: US11026909B1 08/06/2021

Applicant:

RAJU NADIMPALLY SATYAVARAHALA [IN]
ATTILI VENKATA SATYA SURESH [IN]
VARMA NADIMPALLY NEHA [IN]
MOORE STEVEN JEROME [US]
MOORE CULLEN THOMAS [US]

Absstract of: US11026909B1

A method for amelioriation of, or prophylaxis against, a viral infection comprising administering to a patient in need of treatment a therapeutically effective amount of 5 aminolevulinic acid, optionally with at least one of cucumarin nano, zinc, vitamin C and methylene blue, and compositions thereof. Such compositions may be used for the treatment of coronavirus infections, including the SARS-CoV-2 virus, and/or rhinoviruses.

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Anti-SARS-Cov-2 antibodies derived from 3bgf

Publication No.: US11028167B1 08/06/2021

Applicant:

CENTIVAX INC [US]

Absstract of: US11028167B1

This disclosure provides antibodies and antigen-binding fragments that are derived from 3bgf and that can be administered to an individual that is infected or suspected of being infected with a virus. Antibodies and antigen-binding fragments herein can be capable of treating or curing the virus, and which may provide protection against the virus for up to several weeks. Antibodies and antigen-binding fragments herein can be used to diagnose a SARS CoV-2 infection.

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METHOD FOR PREPARATION OF BETULIN FOR USE AS ADJUVANT IN VACCINE AGAINST SARS-COV-2 CORONAVIRUS

Publication No.: RU2749193C1 07/06/2021

Applicant:

OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOSTYU BETUVAKS [RU]

Absstract of: RU2749193C1

FIELD: medicine.SUBSTANCE: invention relates to a method for producing a betulin-based adjuvant for the vaccine against SARS-CoV-2 coronavirus, which provides for sterilizing filtration of a betulin solution in tetrahydrofuran through a nylon membrane with a pore diameter of 0.22 mcm, reducing the content of tetrahydrofuran by adding a 25-fold volume of sterile 0.01 M tris-buffer (pH-9.0±0.1) using a peristaltic pump with constant mixing for 15 minutes with a propeller-type magnetic mixer, followed by ultrasound homogenization at 35-40 kHz for 10 minutes until a homogeneous suspension is obtained with the formation of spherical amorphous homogeneous particles on which proteins of SARS-CoV-2 virus are sorbed.EFFECT: proposed is method for obtaining a betulin-based adjuvant for the vaccine against SARS-CoV-2 coronavirus with high sterility and immunogenicity, which improves the quality of the vaccine against coronavirus.4 cl, 6 dwg, 9 tbl, 2 ex

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Smart COVID-19 Protection Band using AI, IoT and Cloud

Publication No.: AU2021101705A4 03/06/2021

Applicant:

B BALAMURUGAN [IN]
B RADHA KRISHNAN [IN]
N GAYATHRI [IN]
R SRINIVASAN [IN]
S RAKESH KUMAR [IN]
T SATHISH [IN]
V VIJAYAN [IN]

Absstract of: AU2021101705A4

Smart COVID Protection Band using AI, IoT, and Cloud Abstract: COVID cases are in continuous rise day by day, however, the government is taking all sort of steps to aware the citizens about various precautions they can take to avoid the infection and people are also following that as well, but most of the time the corona virus somehow find a way to enter the human body and ultimately makes the person sick. We can't imagine such an invisible virus can cause devastating health issues to human health, being a new virus, our body is unable to fight back this, so it's better to use precautions while we are outside, stay at home if not important, as the growth rate of COVID cases shows the exponential curve and we don't know when this curve will be flattened. If somehow this spread can be minimized then the life of thousands can be saved, and it is possible! Various preventive majors in addition with different technologies can be utilized to solve this issue. One such solution is a smart band that can notify you when you are prone to or at risk of infection by analyzing the COVID data and history of that region and based on a crowd sourced system to give the risk report to the person. In this way, one can know about the risks and prevent ourselves accordingly. This advanced protection band will be based on the phenomena of satellite navigation and presumption of covid cases in particular regions by its past history and nearby cases and showing graphs and analysis so as to alert the

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A deep learning based system for automatic segmentation and quantification of covid-19 in CT images

Publication No.: AU2021101851A4 03/06/2021

Applicant:

VISHWAKARMA INSTITUTE OF INFORMATION TECH [IN]

Absstract of: AU2021101851A4

Abstract A deep learning based system for automatic segmentation and quantification of covid-19 in CT images The present invention relates to a deep learning based system for automatic segmentation and quantification of covid-19 in CT images. This invention uses pre-trained deep learning models. These pre-trained models have to be retrained on the new dataset to do the prediction. Once the training and testing are done on these datasets then we can use these newly trained models, pass new images to them and do the predictions. The final result would notify us whether the image is from an infected class or a non-infected class. "Pv w~iltoo ^ 1% Ill.OM 10 10 Fiur Figre Fi 0re4

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SIMULATION COMPLEX FOR SAFE TRAINING OF MEDICAL PERSONNEL IN CONTEXT OF PANDEMIC

Publication No.: RU2748960C1 02/06/2021

Applicant:

OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOSTYU VIARSIM [RU]

Absstract of: RU2748960C1

FIELD: computer technology.SUBSTANCE: said technical solution relates to the field of computer technology. A simulation complex for medical personnel in a pandemic is proposed, containing at least one XR station, which includes a set of realistic scenarios in virtual reality for practicing the skills of personal safety techniques of medical personnel in a pandemic, as well as the diagnostics and treatment of patients with COVID-19; a computing center for centralized management, monitoring and recording of medical personnel training sessions conducted by at least one XR station, and the XR station contains at least one system for fully immersing the user in virtual reality, and the system for fully immersing the user in virtual reality contains at least wireless virtual reality glasses and a set of wireless bodypack motion capture sensors; a system for tracking users in space, for determining the position and orientation of a real user in a virtual environment, and the tracking system contains at least 2 modules for determining the position and orientation of a user in a virtual environment, which are installed in the corners of the room where safe training of medical personnel in a pandemic is carried out; an administration center containing at least two computing devices, a display device and a video signal transceiver.EFFECT: invention provides safe training of medical personnel in a pandemic, as well as expanding the arsenal of technical means of the simulation complex.2 c

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ARTIFICIAL SPUTUM FOR MODELING RESPIRATORY OBSTRUCTION IN COVID-19

Publication No.: RU2748999C1 02/06/2021

Applicant:

URAKOV ALEKSANDR LIVIEVICH [RU]

Absstract of: RU2748999C1

FIELD: medicine; pulmonology; pharmacology; pharmacy; biotechnology; biochemistry; physical and colloidal chemistrySUBSTANCE: artificial sputum is disclosed intended for filling the respiratory tract of an isolated lung and depriving it of airiness for urgent use as a biological model for screening expectorants and foaming agents at the following ratio (wt.%): potato starch is 4.4-22.0; gelatin is 2.2-11.0; sodium chloride is 0.9; blood of an agricultural animal diluted with distilled water in a ratio of 1:1-5.0; distilled water is the rest, at a pH of 7.0-7.4, osmotic activity of 280-300 mOsm/l of water and a temperature of +37°С.EFFECT: invention provides urgent filling of the respiratory tract up to the elimination of airiness and drowning of the isolated lung in water, the possibility of using the lung as a biological model for screening expectorant and oxygen foaming drugs when they are inhaled without burn and frostbite damage to the lung tissues, without the development of cold spasm of the bronchi and without infection of the performers.1 cl, 7 ex

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Producing recombinant SARS-CoV-2 spike protein in a pre-fusion state

Publication No.: US11020474B1 01/06/2021

Applicant:

ABCLONAL SCIENCE INC [US]

Absstract of: US11020474B1

Disclosed is producing recombinant SARS-CoV-2 spike protein in a pre-fusion state, using furin knock out or knockdown mammalian cells (such as HEK293, CHO or other mammalian cells). The pre-fusion state SARS-CoV-2 spike protein can be used as an antigen to generate antibodies/binding molecules for use in SARS-CoV-2 detection assays or in diagnosis of active or prior infection with SARS-CoV-2; as a therapeutic to interfere with SARS-CoV-2 cellular binding; to generate antibodies/binding molecules to SARS-CoV-2 for use in therapy; or, as a vaccine for generating immunity to SARS-CoV-2; or for prophylactic or therapeutic use against related coronaviruses.

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Transmucosal dosage forms of remdesivir

Publication No.: US11020349B1 01/06/2021

Applicant:

JUBILANT GENERICS LTD [IN]

Absstract of: US11020349B1

Disclosed herein are the sublingual pharmaceutical compositions comprising remdesivir or its pharmaceutically acceptable salts or solvates thereof. The present invention also relates to a process for preparing sublingual pharmaceutical compositions comprising remdesivir or its pharmaceutically acceptable salts or solvates thereof. Compositions of remdesivir prepared as per present invention are able to increase bioavailability by avoiding first-pass metabolism. The compositions of remdesivir prepared as per present invention are useful in the treatment of viral infections including coronavirus infection (COVID-19). The compositions of remdesivir prepared as per present invention exhibit desired pharmaceutical technical attributes such as pH, assay, related substance, disintegration and dissolution.

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Anti-SARS-Cov-2 antibodies derived from 2GHW

Publication No.: US11021531B1 01/06/2021

Applicant:

CENTIVAX INC [US]

Absstract of: US11021531B1

This disclosure provides antibodies and antigen-binding fragments that are derived from 2ghw and that can be administered to an individual that is infected or suspected of being infected with a virus. Antibodies and antigen-binding fragments provided herein can be capable of treating or curing the virus, and which may provide protection against the virus for up to several weeks. Antibodies and antigen-binding fragments provided herein can be used to diagnose a SARS-Cov-2 infection.

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Method and apparatus for performance of thermal bronchioplasty to reduce covid-19-induced respiratory distress and treat covid-19-damaged distal lung regions

Publication No.: US11020618B1 01/06/2021

Applicant:

AERWAVE MEDICAL INC [US]

Absstract of: US11020618B1

Apparatus and methods for deactivating pulmonary nerves extending along the main bronchi of a mammalian subject to reduce ARDS effects by advancing an ultrasound transducer into the right and subsequently left main bronchus. The ultrasound transducer emits circumferential ultrasound so as to heat a circumferential tissue volume encompassing the right and left main bronchus. The energy of <10 W acoustic for <5 sec will not be sufficient to cause tissue necrosis but sufficient to inactivate nerve conduction. This treatment can be performed without locating or focusing on individual pulmonary nerves.

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Cold-adapted live attenuated severe acute respiratory syndrome coronavirus and vaccine containing the same

Publication No.: US11020475B1 01/06/2021

Applicant:

IAC IN NAT UNIV CHUNGNAM [KR]

Absstract of: US11020475B1

Disclosed is cold-adapted live attenuated severe acute respiratory syndrome coronavirus (SARS-CoV-2) prepared by infecting cells with severe acute respiratory syndrome coronavirus and then adapting the severe acute respiratory syndrome coronavirus to a temperature from 37° C. to 22° C. in a step by step manner. Further, a vaccine containing the cold-adapted live attenuated severe acute respiratory syndrome coronavirus (SARS-CoV-2) is disclosed.

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Superhuman anti-SARS-CoV-2 antibodies and uses thereof

Publication No.: US11021532B1 01/06/2021

Applicant:

CENTIVAX INC [US]

Absstract of: US11021532B1

This disclosure provides superhuman antibodies and antigen-binding fragments that can be administered to an individual that is infected or suspected of being infected with a virus. Superhuman antibodies and antigen-binding fragments provided herein can be capable of treating or curing the virus, and which may provide protection against the virus for up to at least several weeks. Superhuman antibodies and antigen-binding fragments provided herein can be used to diagnose a SARS Cov-2 infection.

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Phytotherapeutic food supplement anti-SARS-CoV-2

Publication No.: MD1531Y 31/05/2021

Applicant:

MEREUTA ION [MD]
CARAUS VLADIMIR [MD]
STRUTINSCHI TUDOR [MD]

Absstract of: MD1531Y

The invention relates to the food industry, sanocreatology and medicine, in particular to a biologically active, phytotherapeutic food supplement with antioxidant, immunostimulating activity, with inhibition of SARS-CoV-2 virus.The food supplement, according to the invention, comprises an alcoholic extract from: aboveground part of wormwood, aboveground part of cocklebur, maral root, walnut peel, horseradish root, aboveground part of lovage and propolis, obtained by extraction with ethyl alcohol of 96.4% vol. in a ratio of 1:(4-5), respectively, within 15-21 days, and purified water, the rest, until reaching a strength of 32-35% vol.

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Method for identifying the anti-SARS-CoV-2 IgG marker in blood serum

Publication No.: MD1524Y 31/05/2021

Applicant:

AGENTIA NAT PENTRU SANATATE PUBLICA A MINISTERULUI SANATATII MUNCII SI PROTECTIEI SOCIALE AL REPUBLI [MD]

Absstract of: MD1524Y

The invention relates to medicine, namely to a method for identifying the anti-SARS-CoV-2 IgG marker in blood serum and can be used for diagnosing COVID-19 infection.Summary of the invention consists in studying the blood serum by enzyme-linked immunosorbent assay (ELISA) using a microplate adsorbed with specific SARS-CoV-2 antigen and determining the optical density values of samples by the photometric method at a wavelength of 450 nm, then the average optical density value of negative control samples is determined using the formula: the average optical density value of negative control samples + 0.250, then the ratio between the average optical density value of patient's serum and the average optical density value of negative control samples + 0.250 is determined, and if the ratio is up to 0.9, the result is considered to be negative, if it is higher than 1,1 the result is positive; samples with the result of 0.9 are treated with 20% suspension of kaolin of the formula Al2O3·2SiO2·2H2O, then the mentioned enzyme immunoassay is repeated, by subsequently determining the ratio between the average optical density value of patient's serum and the average optical density value of negative control samples + 0.250, if the ratio is up to 0.9, the result is considered to be negative, and if it is higher than 1.1, the result is positive.

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Phytotherapeutic food supplement anti-SARS-CoV-2

Publication No.: MD1532Y 31/05/2021

Applicant:

MEREUTA ION [MD]
CARAUS VLADIMIR [MD]
STRUTINSCHI TUDOR [MD]

Absstract of: MD1532Y

The invention relates to the food industry, sanocreatology and medicine, in particular to a biologically active, phytotherapeutic food supplement with antioxidant, immunostimulating activity, with inhibition of SARS-CoV-2 virus.The food supplement, according to the invention, comprises an alcoholic extract from: aboveground part of wormwood, aboveground part of cocklebur, maral root, walnut peel, horseradish root and aboveground part of lovage, obtained by extraction with ethyl alcohol of 96.4% vol., in a ratio of 1:(4-5), respectively, within 15-21 days, and purified water, the rest, until reaching a strength of 32-35% vol.

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Phytotherapeutic food supplement anti-SARS-CoV-2

Publication No.: MD1533Y 31/05/2021

Applicant:

MEREUTA ION [MD]
CARAUS VLADIMIR [MD]
STRUTINSCHI TUDOR [MD]

Absstract of: MD1533Y

The invention relates to the food industry, sanocreatology and medicine, in particular to a biologically active, phytotherapeutic food supplement with antioxidant, immunostimulating activity, with inhibition of SARS-CoV-2 virus.The food supplement, according to the invention, comprises an alcoholic extract from: aboveground part of wormwood, aboveground part of cocklebur, maral root, walnut peel, horseradish root, aboveground part of lovage and sweet calamus root, obtained by extraction with ethyl alcohol of 96.4% vol., in a ratio of 1:(4-5), respectively, within 15-21 days, and purified water, the rest, until reaching a strength of 32-35% vol.

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METHODS AND DEVICES DETECTING SARS-COV-2

Publication No.: WO2021102210A1 27/05/2021

Applicant:

SARMAL INC [US]

Absstract of: WO2021102210A1

Provided herein are methods, systems and devices for detecting a nucleic acid sequences and/or pathogens; including detecting the presence of absence of a target-nucleic acid sequences, including SARS-COV2.

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Preventive and therapeutic treatment for COVID 19 and any other disease caused by SARS CoV 2

Nº publicación: US11013687B1 25/05/2021

Applicant:

AMCYTE PHARMA INC [US]

Absstract of: US11013687B1

Novel preventive treatment for COVID 19 and therapeutic treatment for early stages of COVID 19 or any other disease caused by SARS CoV 2. Pharmaceutical formulations and devices are disclosed to be able to implement these treatments. These treatments to prevent and alleviate the symptoms at early stages of COVID 19, the pandemic disease caused by SARS CoV 2. These treatments are based on the administration the nasal cavity and/or the lungs of solutions containing iota Carrageenan with or without the addition of xylitol as antiviral drug substances.

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