3D BIOPRINTING

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Resultados 167 results. LastUpdate Updated on 30/11/2022 [18:00:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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OXIDE LAYER-CONTAINING ZIRCONIUM-NIOBIUM ALLOY TIBIAL PLATEAU PROSTHESIS HAVING BONE TRABECULA AND PREPARATION METHOD

Publication No.: EP4094729A1 30/11/2022

Applicant:

JUST MEDICAL DEVICES TIANJIN CO LTD [CN]

WO_2022088704_A1

Absstract of: EP4094729A1

A tibial plateau prosthesis with trabeculae containing zirconium-niobium alloy on oxidation layer and a preparation method thereof. The preparation method uses zirconium niobium alloy powder as raw material, conducting a 3D printing for one-piece molding to obtain an intermediate product of the tibial plateau, performing hot isostatic pressing and cryogenic oxidation to obtain the tibial plateau prosthesis comprising a proximal trabecular layer and a distal trabecular layer; the pore size and porosity of the proximal trabecular layer are evenly arranged, and the distal trabecular layer are partitioned; the topological structure of the trabeculae of the tibial plateau prosthesis is gradiently distributed from three dimensions; the micro-strain in the 64 % - 72 % region of the finite element model of the tibial plateau bone tissue is between the minimum effective strain threshold and the supraphysiological strain threshold, which increases the mechanical adaptation of the prosthesis, and have excellent bone ingrowth; the oxidation layer can realize the excellent biocompatibility of the osseointegration interface, and a friction interface with super wear resistance and low wear rate.

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Method of producing a microneedle array

Publication No.: GB2607115A 30/11/2022

Applicant:

CIPHERX TECH LTD [GB]

Absstract of: GB2607115A

A method of forming a microneedle array, comprising transforming digital information in a digital input pattern/image into microneedle data defining a desired microneedle pattern, masking holes in a master mould to create an array of unmasked holes corresponding to a desired microneedle pattern, and forming a microneedle array having the desired microneedle pattern using the masked master mould. In another aspect, a microneedle array comprising at least first and second microneedles formed from or comprising a polymer containing or encapsulating a first cargo and a second cargo respectively. In another aspect, a microneedle array for delivering a biosensing tattoo that covers graphical information in response to a change in a sensed parameter. In this aspect, the cargo comprises a bio-sensing material configured to change colour or visibility in response to a change in a sensed parameter. In another aspect, a method of authenticating a first tattoo using a second tattoo, comprising reading authentication information encoded in the second tattoo and authenticating the first tattoo by comparing the authentication information to a database of identifiers associated with registered tattoo artists.

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IDENTIFIABLE ANTI-SCATTER GRID FOR A RADIOGRAPHIC IMAGING DEVICE

Publication No.: EP4094690A1 30/11/2022

Applicant:

KONINKLIJKE PHILIPS NV [NL]

Absstract of: EP4094690A1

The present invention provides methods and devices for making an anti-scatter grid for a radiographic imaging device identifiable. A method for providing an anti-scatter grid (100) for a radiographic imaging device comprises forming, by an additive manufacturing process, a grid pattern (110) in accordance with a product specification of the anti-scatter grid (100) to be provided; and forming, by an additive manufacturing process, a number of structural modifications (121) in or at the grid pattern in a manner making the number of structural modifications (121) image-based recognizable and in a unique identification pattern (120) creating a unique identifier to make the anti-scatter grid to be provided identifiable among one or more others.

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EXCESS MATERIAL WITHDRAWAL CONTROL METHOD AND BIOPRINTER

Publication No.: EP4094925A1 30/11/2022

Applicant:

REVOTEK CO LTD [CN]

WO_2021190231_A1

Absstract of: EP4094925A1

Provided are an excess material withdrawal control method and a bioprinter. The excess material withdrawal control method comprises: obtaining the length of a printing material attached to the outside of a nozzle (12) of the printer; and depending on the length of the printing material, withdrawing, by means of a material driving mechanism, the printing material attached to the outside of the nozzle (12) multiple times until the length of the printing material attached to the outside of the nozzle (12) is not greater than an allowable value. According to the excess material withdrawal control method, the printing material attached onto the nozzle (12) of the printer can be effectively removed.

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3D打印MOFs粒子网络水凝胶及制备方法和应用与水凝胶湿滑半月板替代物及制备方法

Publication No.: CN115403789A 29/11/2022

Applicant:

中国科学院兰州化学物理研究所烟台先进材料与绿色制造山东省实验室

Absstract of: CN115403789A

本发明提供了一种3D打印MOFs粒子网络水凝胶及制备方法和应用与水凝胶湿滑半月板替代物及制备方法,涉及水凝胶材料、3D打印制造和医疗器械技术领域。本发明将聚乙烯醇水溶液、羧甲基纤维素钠和MOFs有机配体混合,将所得水凝胶墨水进行直书写3D打印,得到含MOFs有机配体的3D打印水凝胶结构;将所述3D打印水凝胶结构依次进行冷冻和解冻,然后在金属盐有机溶液中浸泡后进行水交换平衡,得到3D打印MOFs粒子网络水凝胶。本发明制备得到的3D打印MOFs粒子网络水凝胶兼具优异的机械性能、亲水性、耐溶胀性、润滑性以及高的打印精度,用于制备半月板替代物,能得到兼具高承载和水润滑性能的水凝胶湿滑半月板替代物。

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ADDITIVE MANUFACTURING PROCESS

Publication No.: CN115401909A 29/11/2022

Applicant:

登士柏德特里有限公司

US_2022031576_A1

Absstract of: EP3659546A1

An additive manufacturing process comprising:(a) providing a curable composition comprising:(i) a filler comprising glassflakes having a diameter D3,99as determined by light scattering in the range of from 5 to 150 µm; and(ii) one or more curable compounds;(b) controlling an apparatus to form an object by using the curable composition, whereby the curable composition passes a discharge orifice having a minimum diameter Φmin,wherein the ratio of the minimum diameter of the discharge orifice to the diameter D3,99of the glassflakes (Φmin/D3,99) is in the range of 2 to less than 10.

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一种资料自助打印设备

Publication No.: CN217932847U 29/11/2022

Applicant:

曹梦宇

Absstract of: CN217932847U

本实用新型涉及自助打印设备技术领域,具体涉及一种资料自助打印设备,包括主机、底座、喷管和消毒水箱,消毒水箱的上端分别安装有时控器和微型水泵,喷管的内壁均安装有雾化喷嘴。本实用新型克服了现有技术的不足,通过设置有消毒水箱、时控器、微型水泵和喷管,使得利用时控器对微型水泵的开启时间和工作时长时间进行设定好,接着当时控器设定的时间达到后,会触发微型水泵进行开启做功,将消毒水箱内的消毒液传输到喷管处,再由喷管内壁的各个雾化喷嘴对消毒液进行喷出,实现对本设备的操控面板和显示屏处进行杀菌消毒工作,使得可以减少在利用本设备对资料打印时的病毒传播危险,也减少工作人员对本设备维护时的劳动强度。

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马来酸改性细菌纤维素的方法及其产品和应用

Publication No.: CN115400143A 29/11/2022

Applicant:

南京林业大学

Absstract of: CN115400143A

本发明公开了一种马来酸改性细菌纤维素的方法及其产品和应用。本发明以安全的食品级马来酸作为改性剂,细菌纤维素为原料,制备纳米细菌纤维素,并与明胶进行复合制备细菌纤维素‑明胶油墨。通过3D打印技术打印生物支架,将其应用于大鼠颅骨缺损模型中进行修复实验,结果表明所制备的马来酸处理细菌纤维素‑明胶支架具有良好的促进颅骨缺损修复能力,修复效果达到空白组的2.21倍。本发明通过马来酸改性细菌纤维素制备细菌纤维素‑明胶生物支架在促进骨缺损修复方面效果显著,具有巨大的应用潜力和经济效益。

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基于人源脱细胞基质的生物墨水及其制备方法与应用

Publication No.: CN115382020A 25/11/2022

Applicant:

银丰低温医学科技有限公司银丰生物工程集团有限公司

Absstract of: CN115382020A

本发明公开了一种基于人源脱细胞基质的生物墨水及其制备方法与应用,属于3D打印生物墨水制备领域。所述生物墨水由以下组分组成:脱细胞基质,4%~15%;明胶,8%~17.5%;壳聚糖,0.1%~3.5%;琼脂,0.5%~3.5%;余量为水。本发明还公开了该生物墨水的制备方法,以及在制备生物支架中的应用。本发明的生物墨水,将脱细胞基质经过冻干研磨成细粉,作为生物墨水成分直接加入,不需要加入胃蛋白酶等外来物,不需要进行消化处理,粘度适合、可打印性较好。利用本发明的生物墨水制备生物支架时不需要使用光固化打印方式,因此不需要用到有毒的光引发剂,且打印支架经冻干后机械性能较好。具有较好的作为植入性组织工程支架的潜力。

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仿生人工韧带及其制备方法

Publication No.: CN115382018A 25/11/2022

Applicant:

吉林大学

Absstract of: CN115382018A

本发明提供一种仿生人工韧带及其制备方法,属于骨骼韧带修复技术领域。其中,本发明的制备方法包括:形成纤维/基质一体化的自增强韧带支架;在所述自增强韧带支架表面修饰细胞粘附层;在表面修饰后的所述自增强韧带支架端部进行矿化处理,以得到仿生人工韧带。本发明实现了纤维/基质结构的一体化成型,并且保证了纤维增强相与基相之间界面连接与融合度,从而进一步提高材料的力学性能,同时表面修饰的细胞粘附层将有利于成纤维细胞的长入,而末端骨质附着区域的矿化也有利于与周围骨性组织的长入与融合,解决现有人工韧带生物活性差,组织融合度低的缺点,从而增强人工韧带的中远期修复效果。

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CONTINUOUS UNLOADING AND PACKAGING SYSTEM FOR PHARMACEUTICAL ADDITIVE MANUFACTURING

Publication No.: CN115397652A 25/11/2022

Applicant:

南京三迭纪医药科技有限公司

TW_202138161_A

Absstract of: WO2021164660A1

A high throughput, efficient, and simplified unloading and packaging systems and methods for large-scale production of pharmaceutical units (104) using additive manufacturing. The systems and methods may unload, inspect, package, and trace pharmaceutical units, produced by an additive manufacturing system (900), that are not damaged or deformed. The unloading and packaging system can include one or more unloading and packaging devices(100). The unloading and packaging device can include a modular configuration having modules. Individual modules to be arranged in any relative order, at any location, and with any number in the unloading and packaging device. The flexibility of the modular configuration allows one or more modules to be removed or added at any given time due to, e.g., expansion, downsizing, module repair, module upgrades, etc. High throughput can be achieved by operating unloading and packaging devices independently.

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一种I期临床试验用生物样本密集采样智能管理操作车

Publication No.: CN115381446A 25/11/2022

Applicant:

无锡市第九人民医院

Absstract of: CN115381446A

本发明提供一种I期临床试验用生物样本密集采样智能管理操作车,属于样本采集技术领域。该I期临床试验用生物样本密集采样智能管理操作车包括第一存储件、第二存储件、第三存储件以及第四存储件。本发明方便用户按照受试者采样的时间顺序直接获取贴有对应标签和符合温控条件的采样管,并集成有具备温控、暂时存储和智能核对生物样本信息功能的智能样本管架,大幅度地减少用户的工作量,提高用户的工作效率,提升用户的工作质量;第一存储件、第二存储件、第三存储件、第四存储件从左至右依次设置,方便在操作车上整齐摆放物品,方便用户快速找到需要的物品,方便用户在不同的区域上进行不同的工作,互不干扰,提高工作效率和工作质量。

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PHYSICAL 3D ANATOMICAL STRUCTURE MODEL FABRICATION

Publication No.: JP2022176214A 25/11/2022

Applicant:

コーニンクレッカフィリップスエヌヴェ

JP_2019511942_A

Absstract of: WO2017140611A1

In one aspect of the invention a system and method is claimed for providing model parameters for three dimensional fabrication of anatomical structures by obtaining and reconstructing three dimensional image data with a medical imager wherein imaging acquisition parameters of the imaging system and/or reconstruction input parameters of the reconstructor are optimized for maximum geometry precision. Advantageously, the imaging system is further configured to obtain material and/or functional information of the anatomical structure model and that material information is used to incorporate the material information in the anatomical model.

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一种基于桁架结构的3D打印多孔种植体及其制造方法

Publication No.: CN115381570A 25/11/2022

Applicant:

江苏万疆高科技有限公司

Absstract of: CN115381570A

本发明提供了一种基于桁架结构的3D打印多孔种植体及其制造方法,种植体包括种植体本体,种植体本体外表面设置有外螺纹,种植体本体内中上部的中心位置开设螺纹孔,种植体本体内靠近下端位置设置空腔,空腔位于螺纹孔下方,空腔内设置空间桁架结构,空腔通过空间桁架结构与种植体本体外部连通。本发明中,利用空间桁架结构能够增加种植体本体的结合面积,从而提高种植体本体的稳定性,避免种植体本体出现晃动甚至脱落的问题,延长了种植体本体的使用寿命。

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一种挤出式陶瓷义齿3D打印机

Publication No.: CN217891276U 25/11/2022

Applicant:

长沙泽尔顿新材料有限公司

Absstract of: CN217891276U

本实用新型提供一种挤出式陶瓷义齿3D打印机,涉及义齿制造技术领域,包括底板,所述底板上表面对称固定连接有第一安装板,底板右侧表面靠近第一安装板位置固定连接有支撑板,所述支撑板上表面固定安装有第一电机,所述第一电机输出端与第一安装板滑动贯穿。本实用新型中,通过电动伸缩杆控制出料头向下移动,对模具出料制作出义齿,第一电机可以调整出料头在X轴上的位置,第二电机可以调整出料头在Y轴上的位置,通过第一电机和第二电机的配合工作,可以控制出料头调整位置,以方便出料头可以针对不同厚度的位置调整出料速度,避免了因出料不均导致义齿内会形成空洞的问题,提升了制作出义齿的质量。

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INFORMATION PROCESSING APPARATUS AND METHOD OF CONTROLLING INFORMATION PROCESSING APPARATUS

Publication No.: JP2022175846A 25/11/2022

Applicant:

キヤノン株式会社

US_2022362418_PA

Absstract of: US2022362418A1

An information processing apparatus includes a sterilization unit that performs sterilization with an ultraviolet light source a part of the information processing apparatus that is operated on, a management unit that manages lifetime information corresponding to a product lifetime of the ultraviolet light source and usage information corresponding to an irradiation time and an irradiation output of the ultraviolet light source, and a control unit that controls the ultraviolet light source in a first control mode of controlling the ultraviolet light source with a first irradiation time and a first irradiation output or in a second control mode of controlling the ultraviolet light source with a second irradiation time shorter than the first irradiation time and a second irradiation output higher than the first irradiation output.

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一种可用于低温沉积3D打印的脱细胞基质及其制备方法和应用

Publication No.: CN115382023A 25/11/2022

Applicant:

北京积水潭医院

Absstract of: CN115382023A

本发明公开了一种可用于低温沉积3D打印的脱细胞基质及其制备方法和应用,属于组织工程再生医学领域。本发明提供的脱细胞基质的制备方法,包括如下步骤:(1)将动物组织进行脱细胞处理,得到脱细胞基质匀浆;(2)在所述脱细胞基质匀浆中加入乙酸溶液,搅拌,然后让部分乙酸挥发,得到所述脱细胞基质。本发明制备的脱细胞基质具有剪切变稀性和3D可打印性,可以实现脱细胞基质单一材料的3D打印。

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TREATMENT OF TEETH BY ALIGNERS

Publication No.: US2022374119A1 24/11/2022

Applicant:

ALIGN TECHNOLOGY INC [US]

ES_2869673_T3

Absstract of: US2022374119A1

A method for treating a subject's teeth. A target configuration for the subject's teeth is determined. Receiving features are produced on a dental base in response to the target configuration, the receiving features being configured to receive physical tooth models. The physical tooth models are assembled on the dental base to form a physical arch model. A dental aligner is produced using the physical arch model to move the subject's teeth to the target configuration.

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SENSOR CHIP AND METHODS THEREOF

Publication No.: US2022373562A1 24/11/2022

Applicant:

NAT UNIV SINGAPORE [SG]

JP_2022519067_A

Absstract of: US2022373562A1

The present disclosure relates generally to a sensor chip and methods for the detection of an analyte. In particular, the disclosure relates to a sensor chip for detecting an analyte in a subject suffering from a neurodegenerative disease. The sensor chip comprises a conductive layer on a membrane support layer, wherein a plurality of apertures extend through the conductive layer and the membrane support layer and are arranged such that illumination of the conductive layer and/or the membrane support layer produces a surface plasmon resonance.

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CONTROLLING THE SIZE OF 3D PRINTING HYDROGEL OBJECTS USING HYDROPHILIC MONOMERS, HYDROPHOBIC MONOMERS, AND CROSSLINKERS

Publication No.: US2022370188A1 24/11/2022

Applicant:

LUNG BIOTECHNOLOGY PBC [US]

WO_2022236030_PA

Absstract of: US2022370188A1

The present disclosure provides printable compositions comprising: about 1 weight percent (wt %) to about 40 wt % of one or more hydrophilic monomers; a swelling control agent selected from a hydrophobic monomer, a short chain crosslinker, or a combination thereof; about 0.01 wt % to about 2 wt % of a photo initiator; and 0 wt % to about 75 wt % of a vehicle comprising a protic solvent, by weight of the printable composition. The disclosure also includes methods of use and manufacture related to printable compositions.

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ARTIFICIAL ESOPHAGEAL STRUCTURE HAVING MULTI-LAYER STRUCTURE USING THREE-DIMENSIONAL BIO-PRINTING, AND MANUFACTURING DEVICE AND MANUFACTURING METHOD THEREFOR

Publication No.: US2022370189A1 24/11/2022

Applicant:

UNIV WONKWANG CT IND ACAD COOP [KR]
POSTECH RES & BUSINESS DEV FOUND [KR]
THE CATHOLIC UNIV OF KOREA INDUSTRY ACADEMI COOPERATION FOUNDATION [KR]

KR_20210037052_PA

Absstract of: US2022370189A1

Disclosed are an artificial esophageal structure having a multi-layer structure using three-dimensional bio-printing, and a manufacturing device and manufacturing method therefor. The artificial esophageal structure having a multi-layer structure according to one embodiment of the present invention comprises: a first layer in the shape of a hollow column and having a circular cross section; a second layer which is disposed inside the first layer and which is a column structure that simulates the mucosal layer of the esophagus; and an interlayer support part which is disposed between the first layer and the second layer and which maintains a gap between the layers, wherein the first layer and second layer each comprise: a plurality of column parts disposed at predetermined intervals; and a plurality of strands formed between the plurality of column parts by a dragging technique, and may have a porous structure due to pores between the plurality of strands.

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SEMI-STABLE NEAR-FIELD ELECTROSPUN SCAFFOLDS AND METHODS OF MAKING AND USING THE SAME

Publication No.: US2022370191A1 24/11/2022

Applicant:

THE UNIV OF MEMPHIS RESEARCH FOUNDATION [US]

Absstract of: US2022370191A1

Methods of producing hybrid fibrous scaffolds are provided. The methods include dissolving a polymer, such as polydioxanone, in a solution, such as 1,1,1,3,3,3-hexafluoro-2-propanol (HFP), to form a polymer-containing solution. The method comprises electrically charging the polymer-containing solution. The method comprises writing the polymer-containing solution on a counter electrode or a ground in a grid pattern to form semi-stable fibers comprised of the polymer, the semi-stable fibers vary between bent and straight and forming the hybrid fibrous scaffold. The writing may be performed by a 3D printer. The resulting scaffolds and methods of using the same are also disclosed herein.

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ENDOPROSTHESIS AND METHOD OF MANUFACTURING AN ENDOPROSTHESIS

Publication No.: US2022370193A1 24/11/2022

Applicant:

KARDIOZIS SAS [FR]

BR_112022004370_A2

Absstract of: US2022370193A1

The invention relates to an endoprosthesis (1), in particular a vascular stent or a heart stent, comprising at least one body (3) part. At least one area (5,6) of an outer surface, preferably the whole outer surface, of the at least one body part (3) is provided with thrombogenic fibers (2). The invention further relates to methods of manufacturing endoprostheses (1).

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METHOD TO BIOPRINT A PATIENT SPECIFIC BONE GRAFT

Publication No.: US2022370204A1 24/11/2022

Applicant:

HARTMAN MICHAEL J [US]

Absstract of: US2022370204A1

A system or method for bioprinting bone graft provides obtaining an image of the patient's oral facial area, and viewed with the image viewing software. A restoratively driven dental implant treatment plan is created to restore the patient's missing dentition. The restoratively driven treatment plan is created. A physical exam, review of a patient's desires and expectations, review of imaging, acquisition and review of patient photographs and intraoral digital impressions. The imaging and digital impressions are aligned, via software to create a virtual representation. The anticipated final implant retained dentures, unitary implant crowns, or implant bridges, are planned to provide optimal esthetic and functional results. Dental implants are then planned for prosthetic anchors. Bone deficiencies are evaluated and if areas of boney deficiency are present, a patient specific bone graft is designed to restore said deficient areas. Once designed, it may be printed via additive manufacturing.

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3D PRINTED STRUCTURALLY SOUND PROSTHETIC SOCKET

Nº publicación: US2022370202A1 24/11/2022

Applicant:

PREC VALVE & AUTOMATION INC [US]

Absstract of: US2022370202A1

A method for 3D printing a prosthetic socket from a digital model, including printing a solid wall perimeter of the prosthetic socket with a width achieved in a single pass of a printing nozzle, and forming a plurality of stiffener elements proximate a bottom end of the prosthetic socket, as a function of the printing the solid wall perimeter, is provided. Also provided is a 3D printed prosthetic socket including an upper portion, a lower portion configured to be attached to a prosthetic pylon, and a plurality of stiffener elements radially extending from the lower portion, wherein the upper portion, the lower portion, and the plurality of stiffener elements are printed as a solid wall construction comprised of a printing material deposited using only a single pass of a printing nozzle.

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