Absstract of: WO2021230789A1

A bioprinter (1) comprising at least one printhead (4a, 4b, 4c) with nozzle (5), a printbed (20) onto which the printhead (4a, 4b, 4c) is arranged to print an ink, an ultrasonic sensor arrangement arranged at the printbed (20), a controller (7) arranged to control movement of the printhead/nozzle (4a, 4b, 4c; 5) and to perform calibration of the printhead/nozzle (4a, 4b, 5 4c; 5) based on information from the ultrasonic sensor arrangement.

Absstract of: EP4151407A1

The present invention addresses the problem of providing a body-mounted component, molded using a 3D printer, which has excellent flexibility, with which the occurrence of breakages and the like when bent is suppressed, and which has a comfortable fit, and a method for manufacturing the same. A body-mounted component according to the present invention is mounted around a joint of the body, and is characterized in that the body-mounted component is formed by means of a resin material for a 3D printer, and in that the tensile elongation at fracture of the resin material is at least equal to 200%. Further, the method for manufacturing the same is characterized by including: a step 1 of forming a powder of the resin material for the 3D printer into a thin layer; a step 2 of selectively shining laser light onto the formed thin layer to form a molded object layer obtained by sintering or melt-bonding resin particles contained in the powder; and a step 3 of laminating the molded object layers by repeating step 1 of forming the thin layer and step 2 of forming the molded object layer a plurality of times, in this order.

Absstract of: WO2022040538A1

There is disclosed a talus implant comprising a base having at least one hole and at least one pin. There is also a top comprising at least one hole and at least one pin, wherein the top is configured to be inserted into the base. At least one embodiment comprises a tibial implant comprising at least one post and at least one base coupled to the at least one post. Additionally, there is at least one pad coupled to the at least one base, wherein the at least one pad is selectively insertable into and removable from the at least one base. A method for fabricating a talus and tibial implant is disclosed and also a method for inserting a talus implant and a tibial implant into a patient having a damaged talus joint.

Absstract of: CN115814152A

本发明涉及一种具有定向排列纤维微结构的高强度互穿网络(IPN)水凝胶血管的制备方法，其包括：准备水凝胶血管的原材料，配制生物水凝胶溶液；采用3D打印或者模具灌注的方法，制备管状水凝胶血管；通过控制温度变化和蓝光照射实现IPN水凝胶的制备；将IPN水凝胶置于管状水凝胶风干的设备，采用限制性风干的方法处理定向排列纤维结构的生成，最后复水保存。本发明的方法，简便易行，选用生物源性水凝胶，利用3D打印技术制备，打印过程与互穿网络形成过程同时进行；在水凝胶内部自发形成的纤维结构增强了其在特定方向的强度。本发明的方法，除制备血管外，还可用于制备各种需要较大力学强度的生物组织，例如肌肉、韧带等，以进行体内或体外的研究。

Absstract of: WO2018193306A2

A system for forming a product with different size particles is disclosed. The system comprises at least one print head region configured to retain a first group of print heads configurable to additively print at least a first portion of the product with a first material and a second group of print heads configurable to additively print at least a second portion of the product with a second material. The described system may also comprise a processor configured to regulate the first group of print heads and the second group of print heads to distribute the first material and the second material. A method of making an object by ink jet printing using the disclosed system is also disclosed.

Absstract of: US2021290434A1

A macular indentor for implantation on an eye of a patient includes a curved backbone extending from a first end to a second end and a raised pad coupled to the first end of the backbone. The raised pad extends inward from an inner face of the backbone such that, when the macular indentor is implanted on the eye, the raised pad applies pressure to the sclera of the eye which contacts the macula of the eye. The geometry of the backbone is configured to match the geometry of the eye.

Absstract of: CN115813615A

本发明属于骨科医疗器械相关技术领域，并公开了一种表面多孔的髋臼杯假体分区设计及成型方法，其包括：髋臼杯球形壳体的建模；髋臼杯球壳壳体的等分分区切割；多孔层在分区髋臼杯假体表面的一体化设计；分区髋臼杯假体的重组；半球形髋臼杯假体的构建；以及髋臼杯假体的3D打印制造。通过本发明，所形成的多孔层垂直于髋臼杯表面，因此其具有优异的力学性能；其具有完全互联的枝杆结构且不存在孤立的杆，避免了术后长期活动的过程中孤立杆的脱落引发的炎症甚至是重新翻修。此外，该多孔层可以是任意形状的多孔结构且非常便利地成形到髋臼杯表面上，可针对促进骨长入的孔径和孔隙率进行设计，并满足长寿命、高生物相容性髋臼杯假体植入物的需求。

Absstract of: CN115813507A

一种皮肤固定骨骼标志定位的3D打印经皮穿刺定位模板制作技术，本发明属于微创治疗领域，涉及3D建模及3D打印领域。利用3D建模软件及3D打印技术，制作个性化的穿刺模板，用以解决穿刺过程不确定危险性及放射性图像引导多次曝光使患者接受过多辐射的问题。

Absstract of: CN115814151A

本发明公开了一种3D打印骨植入物表面多级微米结构的制备方法，属于人工假体的技术领域。其具体包括如下步骤，S1、准备3D打印钛合金骨植入体，S2、预清洗，S3喷砂处理、S4酸蚀处理、S5、二次清洗，S6、碱处理，S7、三次清洗。本发明具有较好的亲水性并提高了生物活性。

Absstract of: WO2022045796A1

Disclosed are a composition for forming a clear orthodontic appliance, a method for manufacturing a clear orthodontic appliance, and a clear orthodontic appliance manufactured by the method. The disclosed composition for forming a clear orthodontic appliance comprises: 100 parts by weight of a first photocurable compound represented by chemical formula 1; 35-75 parts by weight of a second photocurable compound represented by chemical formula 2; 15-65 parts by weight of a third photocurable compound represented by chemical formula 3; 5-40 parts by weight of a fourth photocurable compound represented by chemical formula 4; and 1-15 parts by weight of a fifth photocurable compound represented by chemical formula 5.

Absstract of: CN218642832U

本实用新型提供了一种用于牙种植体的一体式保护帽和种植体组件，一体式保护帽包括一体成型的底座、颈部连接结构和顶部连接结构；所述颈部连接结构包括第一凹槽；其中，所述底座的外形与酸蚀夹具适配，所述颈部连接结构连接所述底座和所述顶部连接结构，所述顶部连接结构用于连接种植体；所述第一凹槽围设在所述颈部连接结构与所述种植体的近端的抵接处，且所述第一凹槽与所述种植体的颈部相适配。本实用新型能够在对所述种植体的表面进行酸蚀的过程中很好地保护种植体的内部以及所述顶部连接结构，从而延长所述一体式保护帽的使用寿命，节约资源。

Absstract of: CN115805702A

本发明公开了一种口腔正畸中用于精准粘接托槽的3D打印工具及方法，涉及口腔正畸技术领域。此工具是以软的3D打印原料制作的半包围式及开窗式的托槽定位导板。方法是首先生成患者牙部的数字化模型，在数字化模型上定位托槽粘接位置；然后围绕粘接托槽位置设计半包围式及开窗式的托槽定位导板；选择合适的3D打印原料打印所述托槽定位导板；将3D打印成的托槽定位导板佩戴在患者口内，再由托槽定位导板确定的空格位置进行患者口内托槽粘接；完成后将托槽定位导板撕掉。本发明通过影像学、3D打印技术、数字化设计的结合与应用，实现化繁为简，使口腔正畸固定矫治变得更科学、精确和便捷，降低投入成本、提高效率，应用前景广阔。

Absstract of: CN115804677A

本发明涉及医疗设备的技术领域，更具体地，涉及一种矫形装置。一种矫形装置，包括脊柱矫形模块：所述脊柱矫形模块通过物理方法利用三点或四点矫正规律对身体凸出的位置进行外部施加压力；智能检测模块：实时监控患者佩戴脊柱矫形支具的压力和温度情况；红外热疗模块：采用纳米石墨烯技术施加电压后释放远红外线；穴位刺激模块：所述穴位刺激模块向穴位施加低频电流和低频震动刺激。本发明脊柱矫形支具采用3D打印便于患者穿戴；而且通过上述模块的综合作用，本矫形装置便于检测患者穿戴脊柱矫形支具的压力数据以及温度数据并通过提醒装置提醒，而且便于监护人可远程掌握实时检测数据；能提升用户体验，并且刺激穴位，增强治疗效果。

Absstract of: US2018133955A1

Systems, methods, components, and materials are disclosed for stereolithographic fabrication of three-dimensional objects. A resin including particles dispersed in a binder system can be substantially transparent to light of a wavelength sufficient to cure at least one component of the binder system. A green object can be formed by activation light penetrating into each layer of a plurality of layers of the resin in a layer-by-layer process to crosslink, polymerize, or both, at least one component of the binder system in successive layers of the resin to one another. Through subsequent processing, the green object can be densified to form a metal object, a ceramic object, or a combination thereof.

Absstract of: WO2020005386A1

Systems and methods of simulating dental treatments are disclosed. A method may include capturing a first 2D image of a patients face, including the patients teeth, building a parametric 3D model of the patients teeth based on the 2D image, developing a simulated outcome of a dental treatment of the patients teeth by rendering the 3D model with the patients teeth in one or more positions and/or orientations corresponding to the treatment goals of the dental treatment plan, and rendering a second 2D image of the patients face with teeth according to a simulated outcome of the dental treatment plan. As noted herein, the dental treatment plan may include orthodontic and/or restorative elements. The simulated outcome may correspond to estimated outcomes and/or intended outcomes of the dental treatment plan.

Absstract of: CN115804865A

本发明提供一种用于半月板替代的3D打印支架及其制备方法，设计径向和周向排列纤维的半月板模型，将聚(ε‑己内酯)装入3D打印机的料筒中，进行熔融沉积成型3D打印，得到3D打印半月板支架；将3D打印半月板支架置入氢氧化钠溶液中进行表面处理；将处理后的支架放到半月板形状的模具中，向模具中加入含N‑丙烯酰甘氨酰胺、光引发剂2‑羟基‑2‑甲基苯基丙酮的水溶液，在紫外光下进行自由基聚合反应，得到用于半月板替代的3D打印支架。本方法可通过3D打印对半月板支架的内部结构进行仿生设计，3D打印聚(ε‑己内酯)框架模拟胶原用于抵抗拉伸载荷，氢键超分子聚合物高强度水凝胶用于抵抗压缩载荷，在构建半月板组织替代物方面具有巨大应用潜能。

Absstract of: WO2021146554A1

Lithography fabrication methods for producing polymeric microneedles, microprobes, and other micron-sized structures with sharp tips. The fabrication process utilizes a single-step bottom-up exposure of photosensitive resin through a photomask micro-pattern, with a corresponding change/increase in refractive index of the resin creating a meta-state waveguide within the resin which focuses down additional transmitted energy and forms a converging shape (first harmonic microcone). Energy is diffracted through the tip of the first harmonic microcone as a second harmonic beam to form a second converging shape (second harmonic shape) adjacent the first microcone, followed by additional tertiary harmonic microcones, which can be built upon these structures with application of additional energy.

Absstract of: CN115804673A

本发明涉及一种定制化的颌面修复体及其制备方法，包括以下步骤：患者术前接受颌面部CT断层扫描，获得CT数据以DICOM格式导入数字化外科辅助软件；患者和医生讨论手术方案，在所述数字化外科辅助软件中分离患者剥离区域，并进行模拟设计颌面修复体，所述颌面修复体在接骨处矩阵镂空出用于骨长入的规则多孔结构，获得3D设计模型；对所述3D设计模型进行修复后，以STL文件的格式导入三维打印软件中，打印材料为聚醚醚酮和双向磷酸钙混合形成的植入级丝材，通过喷头熔融挤出逐层打印定制化颌面修复体，进行3D打印，在温度不小于100℃之前拆除所述支撑柱，得到定制化的颌面修复体。该方法易于实现，可操作性强，具有极好的运用前景。

Absstract of: WO2023035767A1

A 3D multi-branch bionic stent, a preparation method therefor and an application thereof. The 3D multi-branch bionic stent comprises: a main fiber tube, one end of the main fiber tube being connected to at least two primary branch fiber tubes, and the end of each primary branch fiber tube being connected to a secondary branch fiber tube; the cross-sectional area of the main fiber tube is equivalent to the sum of the cross-sectional areas of all the primary branch fiber tubes connected thereto; and the tube wall of the main fiber tube, the tube walls of the primary branch fiber tubes and the tube walls of the secondary branch fiber tubes all have pore structures. The 3D multi-branch bionic stent can provide effective mechanical support for defective tissues, and an interconnected network framework thereof facilitates cellular directional arrangement, osmotic growth, and blood vessel and nerve growth, and also facilitates the transfer of nutritional substances and metabolic waste. The stent has low production costs and high production operability, and is highly flexible.

Absstract of: WO2018088594A1

Provided is a mobile image-forming device. A mobile image-forming device according to an embodiment of the present invention comprises: a surface measuring unit for measuring a contact area of a surface area where a print image is to be printed, with the mobile image-forming device; an image processing unit which extracts at least one of unevenness data and moisture data from a measurement result and corrects the print image on the basis of at least one of the extracted unevenness data and the extracted moisture data; and an image forming unit for printing the corrected print image on the surface.

Absstract of: US2023080204A1

Adaptive graft assemblies and methods of manufacture and implantation are provided herein. In particular, such grafts can be 3D printed and can be defined as standard designs or patient-specific, external sheaths customized for specific vein graft dimensions following minimally/non-invasive vein mapping and computational modeling. The external sheath may include one or more layers of various biomaterials to produce customized biomechanical properties. The external sheath may be made to elute specific bioactive drugs allowing for pharmacologic prevention of adverse remodeling in addition to mechanical support. These customizable features may be tailored for each patient individually depending on specific medical history, including hypertension, diabetes, smoking history, anatomy or any pertinent patient attribute. These methods protect vascular grafts, specifically venous grafts, from immediate exposure to arterial pressure that can induce adverse remodeling and graft failure, thereby providing a precision medicine solution to cardiovascular bypass surgery.

Absstract of: US2023079330A1

A system and method for manufacturing custom fit artificial nails includes a 3D surface scanning module and a 3D printing module and use thereof. A central processing module is connected to the 3D surface scanning module and the 3D printing module and performs: operating the 3D surface scanning module to obtain an image of a user's hands/feet; processing the image to create an input 3D model of nails of the user; generating an output 3D model corresponding to artificial nails matching dimensions of the user's nails according to the 3D input model; operating the 3D printing module to manufacture artificial nails according to the output 3D model; and generating medical data by correlating the identified features of the user's nails with known medical conditions, in order to diagnose a medical condition of the user which is known to exhibit the identified features as a symptom. Alternatively, or additionally, medicinal ingredient may be included in the artificial nail to treat the medical condition of the user. Embedded devices, sensors or an RFID chip may be integrated into the artificial nail.

Absstract of: US2023078215A1

In one aspect, the present application provides a method for fabricating shell-shaped dental appliance, comprising: generating a first 3D digital model representing an assembly of a support and a shell-shaped dental appliance, where the support has a first surface that conforms to and clings to a second surface of the shell-shaped dental appliance; and using the first 3D digital model to control a device to discharge successive drops of at least one fluid phase and solidifiable appliance material and successive drops of at least one fluid phase and solidifiable support material to form the assembly slice by slice along a first direction.

Absstract of: US2023082525A1

A virtual model of an intraoral cavity is provided, wherein this process is initialized by a dental clinic, and the design and manufacture of a suitable dental prosthesis for the intraoral cavity is shared between a dental lab and a service center.

Absstract of: US2023082358A1

Current approaches in small diameter vascular grafts for coronary artery bypass surgeries fail to address physiological variations along the graft that contribute to thrombus formation and ultimately graft failure. An interlayer drug delivery system can sustain delivery of heparin through the graft with a high degree of temporal and spatial control. A heparin-loaded gelatin methacrylate interlayer sits between a biohybrid composed of decellularized bovine pericardium and poly(propylene fumarate) and UV crosslinking is controlled via 3D printed shadow masks. The masks enable control of the resultant gelMA crosslinking and properties by modulating the incident light intensity on the graft. High doses of heparin have detrimental effects on endothelial cell function. When exposed to heparin in a slower, more sustained manner consistent with the masks, endothelial cells behave similarly to untreated cells. Slower release profiles cause significantly more release of tissue factor pathway inhibitor, an anticoagulant, than a faster release profile.