3D BIOPRINTING

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Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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一种粘性凝胶复合材料及其制备方法和应用

Publication No.: CN114887122A 12/08/2022

Applicant:

中山大学

Absstract of: CN114887122A

本发明涉及生物材料技术领域,具体公开了一种粘性凝胶复合材料及其制备方法和应用。所述粘性凝胶复合材料包括A区域和B区域,所述B区域分布在A区域的外围,或者所述B区域分布在A区域的两侧,所述粘性凝胶复合材料的弹性模量由B区域向A区域增高。进一步地,所述粘性凝胶复合材料的一个表面设计有抗黏连层。本发明的粘性凝胶复合材料在实现伤口密封的同时,可有效避免伤口与周围组织的黏连,并且,在动态载荷情况下,能够抵抗伤口撕裂。

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CERAMIC SCAFFOLD

Publication No.: CN114901321A 12/08/2022

Applicant:

南加利福尼亚大学阿尔弗雷德··曼恩生物医学工程研究所

WO_2021087335_A1

Absstract of: WO2021087335A1

This disclosure generally relates to a ceramic scaffold. This disclosure particularly relates to a ceramic scaffold useful for bone regenerations. This disclosure also relates to a ceramic scaffold comprising hydroxyapatite (HA), tricalcium phosphate (TCP), or a mixture thereof. This disclosure also relates to a ceramic scaffold with high mechanical strength and flexibility. This disclosure further relates to a ceramic scaffold manufactured through a three-dimensional (3D) printing process, methods of manufacturing a ceramic scaffold and methods of replacing bone in a subject using the ceramic scaffold.

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基于热成像的人工智能糖尿病足溃疡识别的鞋垫剪裁方法

Publication No.: CN114888870A 12/08/2022

Applicant:

温州医科大学

Absstract of: CN114888870A

本发明公开了基于热成像的人工智能糖尿病足溃疡识别的鞋垫剪裁方法,涉及糖尿病鞋垫技术领域,解决了对于糖尿病足溃疡早期的患者,无法识别足溃疡的位置,制作的鞋垫不能将溃疡的位置进行裁剪和患者的足部骨骼还未发生病变,但是其受力点可能出现变化,造成受力分析存在误差的问题。本发明提出的基于热成像的人工智能糖尿病足溃疡识别的鞋垫剪裁方法,以红外热成像技术获取糖尿病患者双足的热图像,以更客观的热图像形式显示足部皮肤因周围神经血管病变引起的皮肤温度情况,进而早期识别足部溃疡发生部位和程度,并基于红外热成像显示的结果,智能化识别并分割图像中的足部病变区域,获得裁剪模板,裁剪个性化鞋垫,满足不同需求。

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METHODS AND SYSTEMS FOR VAGINAL THERAPEUTIC DEVICE FITTING

Publication No.: CN114886651A 12/08/2022

Applicant:

德瑞克·席安

US_2020214617_A1

Absstract of: WO2019051579A1

A variety of medical and non-medical devices are exploited by users to address a wide range of conditions. However, in the vast majority of instances the device has a limited number of options with respect to its fit for the user and its performance. Further, the determination of target performance and fit are established on a qualitative basis rather than a quantitative basis. In many instances these combinations lead to low user acceptance of the device due to the resulting performance and fit issues. Accordingly, it would enhance performance and user acceptance if a quantitative determination provided a recommended type where options exist, and this determination provided the basis of a custom designed device to the user's specific anatomical and/or performance requirements.

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PATIENT-SPECIFIC IMMOBILIZATION STRUCTURE AND SYSTEM AND METHOD FOR FABRICATION THEREOF

Publication No.: US2022249866A1 11/08/2022

Applicant:

ADAPTIIV MEDICAL TECH INC [CA]

Absstract of: US2022249866A1

Systems and methods are provided for modelling and fabricating a patient-specific immobilization support. Image data is obtained for characterizing an exposed surface of a body portion and a support structure employed to support the body portion during imaging. The image data is processed to determine a position and orientation of the support structure based on spatial features of the support structure, and surface data associated with the exposed surface of the body portion is segmented from the image data. The segmented surface data and the position and orientation of the support structure are employed to generate a digital model of a patient-specific immobilization structure that is attachable to the support structure for immobilizing the body portion between the patient-specific immobilization structure and the support structure. Prior to fabricating the patient-specific immobilization structure, an initial digital model may be modified, optionally according to beam parameters associated with a treatment plan.

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Method For Ink-Jet Printing A Silicone-Based Composition Onto A Textile Substrate

Publication No.: US2022250397A1 11/08/2022

Applicant:

SIGVARIS AG [CH]

BR_112021024871_A2

Absstract of: US2022250397A1

A method for ink-jet printing a two-component silicone-based composition onto a textile substrate is presented. The composition includes a first component having at least one silicone polymer and a second component having at least one cross-linking agent. The method includes the following steps: providing a printing system having at least one print head, itself having at least one print nozzle of spraying the two-component silicone-based composition onto the textile substrate, and a device for producing relative movement between the print head and the textile substrate, spraying the first component and the second component onto the textile substrate via the print nozzle cross-linking the silicone polymer by reaction between the first component and the second component so as to form a printed pattern on the textile substrate.

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Arrangements for forming three-dimensional structures, and related methods thereof

Publication No.: AU2021217126A1 11/08/2022

Applicant:

BELLASENO GMBH

WO_2021156292_A1

Absstract of: AU2021217126A1

Embodiments relate to a method for forming a three-dimensional structure. The method includes determining one or more locations for positioning a sensing device based on structural coordinate information relating to a three-dimensional structure to be formed. The method further includes forming a portion of the three-dimensional structure based on the structural coordinate information. The method further includes positioning the sensing device at a location of the one or more locations.

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3D Bioprinted Skin Tissue Model

Publication No.: US2022249738A1 11/08/2022

Applicant:

CELLINK AB [SE]

CN_113950339_PA

Absstract of: US2022249738A1

The present invention relates to a 3D bioprinted skin tissue model, a method for providing said model and the use of said model. The 3D bioprinted skin tissue model comprises at least one bioink A, at least one cell type A, at least one factor A, wherein the bioink A comprises at least one biopolymer, a thickener, at least one extra-cellular matrix or a decellularized matrix, and optionally a photo initiator and/or cellular additions, the at least one cell type A is an epidermal, dermal and/or hypodermal cell or cell line, and the at least one factor A is a growth factor, protein and/or molecule that stimulates altered or abnormal metabolism of cell type A.

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BIOMIMETIC TISSUE AND METHOD OF USE THEREOF

Publication No.: US2022249740A1 11/08/2022

Applicant:

NEW YORK STEM CELL FOUND INC [US]
UNIV NEW YORK [US]

Absstract of: US2022249740A1

Described herein are methods for using localized source of heat, such as thermal scanning probe lithography (tSPL), for the low-cost and high-throughput fabrication of biological tissue replicas.

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MULTI-BLOCK SHAPE MEMORY BIORESORBABLE POLYMERS

Publication No.: US2022251290A1 11/08/2022

Applicant:

EVONIK OPERATIONS GMBH [DE]

KR_20220038392_A

Absstract of: US2022251290A1

This invention relates to the synthesis of multi-block bioresorbable polymers bearing hard and soft polymeric segments. The invention further relates to bioresorbable polymers for shape memory properties. The invention also relates to the use of such polymers as bone filler, vascular closure devices, hemostasis device, aneurysms, mastectomy devices and stent applications. The invention relates also to the use of such polymers for applications in fast degradation applications and 3D printing. The invention also relates to the use of such polymers as drug delivery platforms applications.

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RESIN COMPOSITION FOR STEREOLITHOGRAPHIC MODELING

Publication No.: US2022251275A1 11/08/2022

Applicant:

KURARAY NORITAKE DENTAL INC [JP]

Absstract of: US2022251275A1

The present invention provides a resin composition for stereolithographic modeling emitting a weak odor, having desirable shape accuracy, and made into a cured product having desirable strength, toughness, and color tone when used for stereolithographic modeling. The present invention relates to a resin composition for stereolithographic modeling, comprising: a polymerizable monomer (A); a photopolymerization initiator (B), and an organic peroxide (C), wherein the polymerizable monomer (A) comprises a (meth)acrylic acid ester compound (A-1) having a viscosity of 1,000 mPa·s or less and a normal boiling point of 270° C. or more and/or a (meth)acrylamide compound (A-2) having a viscosity of 1,000 mPa·s or less and a normal boiling point of 200° C. or more, and the photopolymerization initiator (B) is at least one selected from a (bis)acylphosphine oxide, an α-hydroxyketone compound, an α-aminoketone compound, a benzoin alkyl ether compound, a thioxanthone, a ketal, an α-diketone, and an anthraquinone.

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Modeling devices used in guided bone and tissue regeneration

Publication No.: GB2603694A 10/08/2022

Applicant:

OSTEOGENICS BIOMEDICAL INC [US]

CN_114667111_PA

Absstract of: GB2603694A

This disclosure describes manufacturing of a device configured to guide bone and tissue regeneration for a bone defect. A method may include receiving a three- dimensional digital model or scan representing an anatomical feature to be repaired, generating a simulated membrane using the three-dimensional model, the simulated membrane being configured to cover the anatomical feature to be repaired, generating a digital two-dimensional flattened version of the simulated membrane, and generating code or instructions configured to cause a three-dimensional printer or milling device to produce a trimming guide that includes an opening corresponding to the flattened version of the simulated membrane and that further includes a cut-out configured to hold a premanufactured membrane. The trimming guide may be operative as a guide for marking or cutting the premanufactured membrane through the opening while the premanufactured membrane is held in the cut-out.

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3D printed shapable fixation device for wrist, wrist and thumb, thumb, elbow, and palm and method of its manufacture

Publication No.: SK452022U1 10/08/2022

Applicant:

MOLNAR IVAN ING [SK]
MICHAL DAVID ING PHD [SK]

Absstract of: SK452022U1

The 3D printed shapable fixation device for wrist, wrist and thumb, thumb, elbow, and palm is formed by a body (1) containing holes (2) with regular spacing in an inner surface, wherein the body (1) contains holes (3) on two opposite sides to secure the position after shaping with velcro fasteners, it is 2 millimeters thick and is made of PLA (polylactic acid) thermoplastic material. The body (1) is extruded in the form of a plate by gradually adding layers of PLA thermoplastic material, which is pushed in the form of a coil through a heated nozzle and deposited according to software-defined paths on the 3D printer platform.

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RESIN COMPOSITION FOR STEREOLITHOGRAPHY

Publication No.: EP4039722A1 10/08/2022

Applicant:

KURARAY NORITAKE DENTAL INC [JP]

Absstract of: EP4039722A1

The present invention provides a resin composition for stereolithography that enables easy stereolithographical fabrication, and that can produce a cured object having desirable strain recovery, desirable toughness, and desirable water resistance. The present invention relates to a resin composition for stereolithography comprising a polymerizable compound (A) whose homopolymer has a glass transition temperature (Tg) of 37°C or higher, and a photopolymerization initiator (B), and having a tanδ at 37°C of 0.3 or less after cure.

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AIR DELIVERY CONDUIT

Publication No.: EP4039311A1 10/08/2022

Applicant:

RESMED PTY LTD [AU]

JP_2022002707_A

Absstract of: EP4039311A1

The present disclosure relates to a method of forming an air delivery conduit for use in the treatment of sleep disordered breathing, comprising: laminating a polymer to a fabric sheet, wherein the polymer is laminated as diagonal lines across the fabric sheet or wherein the laminated polymer has a skeleton configuration; and forming the fabric sheet into a tubular shape thereby forming a conduit to deliver pressurized air, wherein the laminated polymer functions as a support structure and provides form to the conduit.

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TREATMENT OF TEMPEROMANDIBULAR JOINT DYSFUNCTION WITH ALIGNER THERAPY

Publication No.: EP4039222A1 10/08/2022

Applicant:

ALIGN TECHNOLOGY INC [US]

CN_110809456_A

Absstract of: EP4039222A1

Methods and systems are provided for diagnosing and generating a treatment plan for temporomandibular joint dysfunction where a polymeric shell appliance is utilized to generate one or more activation forces that facilitate tooth movement. The polymeric shell appliances may comprise one or more tooth receiving cavities, in which each of the plurality of tooth receiving cavities is shaped and arranged to provide a counter moment of each of the plurality of teeth.

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RADIATION-CURABLE COMPOSITION FOR USE IN RAPID PROTOTYPING OR RAPID MANUFACTURING METHODS

Publication No.: EP4039223A1 10/08/2022

Applicant:

KULZER & CO GMBH [DE]

Absstract of: WO2020182810A1

The invention relates to a polymerizable radiation-curable composition comprising (i) monomers which comprise at least (a) one first monomer with a homopolymer TG (glass transition temperature) which is greater than or equal to 20 °C and at least (b) one second monomer with a homopolymer TG (glass transition temperature) which is less than or equal to 100 °C, wherein at least one of the at least one first monomer or the at least one second monomer has an alicyclic group, and comprising (ii) at least one second component which comprises at least one photoinitiator for the UV and/or the Vis range or a photoinitiator system for the UV and/or Vis range. The invention additionally relates to a blank in the form of a three-dimensional molded body of a polymerized composition, in particular a radiation-cured composition, for producing 3D molded bodies, such as dental models, dental prosthetic parts, orthopedic instruments, or dental pre-forms and to the use of the composition in order to produce dental prosthetic parts, orthopedic instruments, or dental pre-forms in a rapid prototyping method or in a rapid manufacturing or rapid tooling method.

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负载缓释涂层的3D打印多孔支架及其制备方法和应用

Publication No.: CN114870073A 09/08/2022

Applicant:

四川国纳科技有限公司

Absstract of: CN114870073A

本申请公开了一种负载缓释涂层的3D打印多孔支架及其制备方法和应用,属于生物医学材料技术领域,该支架包括通过3D打印技术成型的多孔支架以及附着在所述多孔支架上的BMP‑2缓释涂层;其中,所述多孔支架的材料为HA/PA66生物复合材料;所述BMP‑2的缓释载体为PVA水凝胶。该制备方法用于制备上述负载缓释涂层的3D打印多孔支架。该负载缓释涂层的3D打印多孔支架可应用于骨缺陷修复材料。本申请的多孔支架能和骨组织形成生物性骨整合,PVA水凝胶在降解过程中逐步释放BMP‑2,以促进成骨,最终在大的缺损腔体内形成以HA/PA为骨架,由新生骨组织包覆且贯穿支架的愈合形态。

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骨替代复合体及其制备方法及用途

Publication No.: CN114870092A 09/08/2022

Applicant:

广州骊贝生物科技有限公司

Absstract of: CN114870092A

本申请公开了一种骨替代复合体及其制备方法及用途,其中,骨替代复合体,包括:支架,用于填充骨缺损部位且被构造为具有多孔结构;功能胶体,用于填充支架的多孔结构且具有流动性;其中,支架包含磷酸三钙;功能胶体包含透明质酸水凝胶。本申请方法包括制备支架和使功能胶体浸入支架,本申请的骨替代复合体用于修复牙槽骨。本申请的有益之处在于提供了一种生物适配性优良且有利于组织生长的骨替代复合体及其制备方法及用途。

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一种选区激光熔化TC4合金基复合材料及其制备方法和应用

Publication No.: CN114875408A 09/08/2022

Applicant:

成都科宁达材料有限公司

Absstract of: CN114875408A

本发明提供了一种选区激光熔化TC4合金基复合材料的制备方法,包括如下步骤:采用酸性溶液对选区激光熔化TC4合金进行腐蚀处理,得到表面腐蚀合金;在所述表面腐蚀合金的表面进行镀膜处理,得到表面为镍铬钼合金镀层的选区激光熔化TC4合金基复合材料。本发明先对选区激光熔化TC4合金进行腐蚀处理,能够去除其表面的夹杂物和应力层,再进行表面镀膜处理,得到表面为镍铬钼合金镀层的选区激光熔化TC4合金基复合材料,其中,合金镀层中的镍和铬元素对氧亲和性较大,显著改善了内生氧化膜的性质,促进TC4合金和陶瓷的化学结合;钼元素作为表面活性剂,改善了镀层的表面质量,进一步提高了TC4合金和陶瓷的物理和化学结合力。

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一种多功能复合支架及其制备方法和应用

Publication No.: CN114869863A 09/08/2022

Applicant:

中山大学附属第三医院

Absstract of: CN114869863A

本申请属于载药平台技术领域,尤其涉及一种多功能复合支架及其制备方法和应用;其中,多功能复合支架具有程序性释放治疗药物的特性,两侧支架上负载的肿瘤血管阻断药物会优先迅速释放破坏肿瘤组织血管内皮细胞,进而引起肿瘤内部部分癌细胞坏死,随后中间静电纺丝膜持久性地释放化疗药物,长时间地作用于残余肿瘤细胞,有效杀伤残留肿瘤细胞,降低肿瘤复发率,本申请通过负载肿瘤血管阻断药物的生物相容性支架叠加在负载化疗药物的可降解静电纺丝膜两侧构成三明治结构,解决了现有技术手段难以有效杀伤残留肿瘤细胞,肿瘤复发率高的技术问题。

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一种用于椎间融合器的3D打印复合材料及制备方法

Publication No.: CN114870076A 09/08/2022

Applicant:

南方医科大学深圳医院

Absstract of: CN114870076A

本发明公开了一种用于椎间融合器的3D打印复合材料及制备方法,包括以下重量份数的原料:45S生物玻璃40~60份、SrO 40~60份、盐酸多巴胺1~3份、Tris‑HCl缓冲溶液20~60份、左旋聚乳酸(PLLA)3~6份、无水乙醇1~3份、蒸馏水3~5份;包括Sr/Bioglass复合及改性、混合粉末制备和Sr/Bioglass/PLLA支架/融合器制备。本发明所述的一种用于椎间融合器的3D打印复合材料及制备方法,基于有限元力学仿真及TPMS构建方法实现融合器“控形”与“控性”操作,复合材料的刚度及强度与人体相匹配、可控降解、具有调控炎症反应、促进成骨、抑制破骨等优点,可促进成骨、加速椎间骨性融合、减少终板骨丢失的生物学机制,解决OLIF椎间融合术后终板塌陷、融合器下沉移位及椎体间骨不连的难题。

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一种聚醚醚酮支架及其制备方法、应用

Publication No.: CN114870077A 09/08/2022

Applicant:

南方科技大学

Absstract of: CN114870077A

本发明公开了一种聚醚醚酮支架及其制备方法、应用,聚醚醚酮支架,包括:具有微孔结构的本体,所述本体的材质为聚醚醚酮;功能层,包括包裹所述本体的聚多巴胺层和复合在所述聚多巴胺层表面的碱性成纤维细胞生长因子。通过在具有微孔结构的本体上涂覆聚多巴胺层,在聚多巴胺层的表面引入碱性成纤维细胞生长因子,使得该聚醚醚酮支架作为植入物时,能够和软组织间形成有效的整合和密封,避免出现感染、松动和移位等并发症。

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基于数字光处理的3D打印组织工程胰岛及其制备方法和用途

Publication No.: CN114870093A 09/08/2022

Applicant:

四川大学

Absstract of: CN114870093A

本发明属于3D生物打印技术领域,具体涉及一种基于数字光处理的3D打印组织工程胰岛及其制备方法和用途。针对现有的3D打印制备胰岛存在着耗时长,打印得到的细胞活性低,胰岛细胞容易渗漏出封装装置等缺陷,本发明提供了一种基于数字光处理的3D打印组织工程胰岛的制备方法,采用中间部位是一个凹槽的圆形图案光,采用甲基丙烯酸化水凝胶溶液溶解于光引发剂为生物打印墨水,固化20秒,逐层打印,得到了直径为7‑12mm,高度为0.5‑2mm的迷你工程胰岛。本发明制备的工程胰岛具有防止胰岛细胞渗漏、胰岛细胞存活率高以及宿主免疫系统对植入材料的反应免疫原性低等特点,有重要科学意义和潜在的临床转化前景,也为未来能为I型糖尿病的临床治疗提供了新的思路。

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HIGH-THROUGHPUT AND HIGH-PRECISCION PHARMACEUTICAL ADDITIVE MANUFACTURING SYSTEM

Nº publicación: JP2022535626A 09/08/2022

Applicant:

トリアステックインコーポレイテッド

US_2022212404_A1

Absstract of: WO2021031824A1

Provided are pharmaceutical products manufactured using additive manufacturing technology. An exemplary printing system comprises: a material supply module for receiving a set of printing materials; a flow distribution module comprising a flow distribution plate, wherein the material supply module is configured to transport a single flow corresponding to the set of printing materials to the flow distribution plate; wherein the flow distribution plate comprises a plurality of channels for dividing the single flow into a plurality of flows; a plurality of nozzles, wherein the plurality of nozzles comprises a plurality of needle-valve mechanisms; one or more controllers for controlling the plurality of needle-valve mechanisms to dispense the plurality of flows based on a plurality of nozzle-specific parameters; and a printing platform configured to receive the dispensed plurality of flows, wherein the printing platform is configured to move to form a batch of the pharmaceutical product.

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