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Resultados 107 resultados LastUpdate Última actualización 19/10/2021 [18:49:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 15 días / Applications published in the last 15 days



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HOLLOW SILICA NANOPARTICLES WITH ENCAPSULATED BIOACTIVE INGREDIENTS, PREPARATION PROCESS AND APPLICATIONS THEREOF

NºPublicación: CN113499319A 15/10/2021

Solicitante:

牟中原

ES_2797779_T3

Resumen de: EP3284483A1

The present invention relates to hollow silica nanoparticles as a drug delivery system loading bioactive ingredients. Particularly, the present invention relates to silica nanoparticles comprising multi-layered silica shells with one or more bioactive ingredients encapsulated within and their applications in drug delivery; and processes of preparing the same.

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红细胞膜包被载药纳米粒/探针及其在脑胶质母细胞瘤诊疗中的应用

NºPublicación: CN113499318A 15/10/2021

Solicitante:

复旦大学附属华山医院

Resumen de: CN113499318A

本发明公开了一种红细胞膜包被载药纳米粒/探针及其在脑胶质母细胞瘤诊疗中的应用;所述红细胞膜包载药纳米粒由人或动物的红细胞膜包被载盐酸阿霉素的聚乳酸‑羟基乙酸共聚物(PLGA)所得。本发明获得的红细胞膜包载药纳米粒具有相似的粒径和形状、提供相对稳定的内环境、动物体内血液中循环时间长和生物相容性、肿瘤中靶向蓄积含量高等特点,可通过荧光成像实现肿瘤诊断,并可使药物在肿瘤部位释放,在体内抑制肿瘤生长、延长动物生存时间。

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ENGINEERED HEPATITIS B CORE POLYPEPTIDE

NºPublicación: CN113508125A 15/10/2021

Solicitante:

小利兰·斯坦福大学托管委员会

US_2020231632_A1

Resumen de: WO2020139843A1

Genetically modified HBc polypeptides are provided.

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COMPOSITIONS AND METHODS FOR INHIBITING POST-SURGICAL ADHESIONS

NºPublicación: CN113507925A 15/10/2021

Solicitante:

北卡罗来纳大学教堂山分校

WO_2020163601_A2

Resumen de: WO2020163601A2

In one aspect, methods are described herein employing particle compositions operable to form composite membrane for inhibition of post-surgical adhesions. Briefly, a method of treating a surgical site comprises contacting the surgical site with a particle formulation comprising targeting particles and scaffolding particles. The targeting particles and scaffolding particles are crosslinked to provide a composite membrane at the surgical site, wherein formation of post-surgical adhesions are inhibited by the composite membrane.

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EXTENDED NITRIC OXIDE-RELEASING POLYMERS VIA FUNCTIONALIZED MESOPOROUS SILICA NANOPARTICLES

NºPublicación: CN113507924A 15/10/2021

Solicitante:

北卡罗来纳大学教堂山分校

WO_2020180705_A1

Resumen de: WO2020180705A1

The subject matter disclosed herein is directed to nitric oxide releasing particles comprising a mesoporous silica network. Also disclosed are compositions comprising one or more nitric-oxide releasing particles and a polymer. In one aspect, the particles are admixed with the polymer. The compositions exhibit high payloads of nitric oxide release without particle leaching or the need for extremely cold storage conditions.

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一种多功能仿生纳米药物的制备方法及应用

NºPublicación: CN113499317A 15/10/2021

Solicitante:

郑州大学

Resumen de: CN113499317A

本发明涉及多功能仿生纳米药物的制备方法及应用,可有效增强肿瘤的光动力治疗,其解决的技术方案是,该多功能仿生纳米药物为在聚乳酸‑羟基乙酸共聚物上包载化疗药藤黄酸,得到载药纳米内核,经超声挤出将类囊体膜‑癌细胞膜复合膜包覆在纳米内核的外侧,构成多功能仿生纳米药物,本发明制备的多功能仿生纳米药物TCPG具有良好的生物相容性,通过特异性同源靶向与增强光动力疗法相结合的策略有效地提高纳米药物的抗肿瘤效果,是纳米药物上的创新。

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COMPOSITIONS COMPRISING NANOPARTICLES, METHOD OF MAKING AND USES THEREOF

NºPublicación: WO2021205411A1 14/10/2021

Solicitante:

ORGANICELL REGENERATIVE MEDICINE INC [US]

US_2021315939_A1

Resumen de: WO2021205411A1

Presented herein, in certain aspects, are cell-free therapeutic composition derived from human amniotic fluid (HAF) and uses thereof for the prevention and treatment of selected diseases and disorders.

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MIMETIC NANOPARTICLES FOR PREVENTING THE SPREADING AND LOWERING THE INFECTION RATE OF NOVEL CORONAVIRUSES

NºPublicación: WO2021205077A1 14/10/2021

Solicitante:

FINNCURE OY [FI]

Resumen de: WO2021205077A1

The present technology provides a method for minimizing the spread of novel coronaviruses such as SARS-CoV-2, which is the causative agent for the global COVID-19 pandemic, by tailored nanomaterials that mimics the infectious agent thus blocking the virus entry to the host by competitive inhibition of target receptors lowering the risk of contracting the COVID-19 disease. According to the invention, a synthetic carrier is provided for use in a method of preventing and reducing SARS-CoV-2 binding to target areas of cell surfaces such as ACE2 receptors of the host organism. The carrier comprises biocompatible particles having a maximum size in at least one dimension in the nanometer or micrometer range, forming a core, and further having a functionalized surface capable of binding to said target areas of said cell surfaces to at least temporarily block said target areas to prevent or minimize pathogen binding and thus, reducing the risk of the host contracting the disease caused by said virus. The nanocarrier can be loaded with active pharmaceutical ingredients e.g. Celastrol, Zinc and Interferon-Gamma modulators for targeted drug delivery by boosting the immune system and/or creating a hostile environment for viral replication lowering the risk of spreading the disease to other organisms.

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NOVEL VACCINE COMPOSITIONS

NºPublicación: WO2021205079A1 14/10/2021

Solicitante:

FINNCURE OY [FI]

FI_20205382_A1

Resumen de: WO2021205079A1

The present technology provides vaccine compositions and a method for selecting immunogenic epitopes from novel coronaviruses such as SARS-CoV-2. The identified epitopes derived from SARS-CoV-2 have high affinity towards specific MHC molecules in humans that are known to elicit an effective T cell response in vitro. The carrier comprises biocompatible particles having a maximum size in at least one dimension in the nanometer or micrometer range, forming a core, and further having a functionalized surface or loaded with the said immunogenic epitopes or nucleotides encoding for said polypeptides capable of eliciting a cell specific protection against the said virus. A temporary or prolonged protection against novel coronaviruses is achieved by stimulating the immune system for efficiently identifying viral-infected cells.

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PRUSSIAN BLUE NANOPARTICLES FUNCTIONALIZATION WITH LATENCY REVERSING AGENTS AND BROADLY NEUTRALIZING ANTIBODIES, AND APPLICATIONS THEREOF

NºPublicación: WO2021207635A1 14/10/2021

Solicitante:

UNIV GEORGE WASHINGTON [US]

Resumen de: WO2021207635A1

Embodiments of the instant disclosure relate to novel compositions and methods for the treatment of retroviruses (e.g., HIV) and the reduction and/or eradication of latent HIV reservoirs. Compositions herein may include biofunctionalized nanocomposites comprised of a core nanoparticle formed of Prussian blue materials, a shell obtained by partially or completely encapsulating the Prussian blue core with at least one biocompatible coating, and at least one biomolecule attached to, or absorbed to, the biocompatible coating and uses thereof.

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LONG-ACTING APOMORPHINE FORMULATIONS AND INJECTORS FOR THERAPEUTIC DELIVERY OF THE SAME

NºPublicación: WO2021207737A2 14/10/2021

Solicitante:

SCIENTURE INC [US]
INNOCORE TECH B V [NL]

Resumen de: WO2021207737A2

The present disclosure is directed to formulations, devices, kits, and methods for treating or preventing motor symptoms associated with Parkinson's disease by injection of a microsphere formulation of apomorphine free base or a pharmaceutically acceptable salt thereof, wherein injection can be from a pre-filled injector.

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CARRIERS FOR EFFICIENT NUCLEIC ACID DELIVERY

NºPublicación: WO2021207020A1 14/10/2021

Solicitante:

TIBA BIOTECH LLC [US]

Resumen de: WO2021207020A1

Nanoparticle compositions for delivery of nucleic acids to subjects including carriers comprising polyester (PE) dendrimers or dendrons, and therapeutic or immunogenic nucleic acid agents enclosed within the PE are described. Methods for treating or preventing diseases or conditions in a subject by administering the nanoparticle compositions that provide immune responses and synergistic therapeutic or preventive effects are provided.

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SYSTEM AND METHOD FOR AEROSOL PARTICLE PRODUCTION OF SUBMICRON AND NANO STRUCTURED MATERIALS

NºPublicación: WO2021207149A1 14/10/2021

Solicitante:

UNIV PRINCETON [US]

Resumen de: WO2021207149A1

Disclosed herein is a multi-purpose aerosol platform capable of producing and delivery of submicron and nano structured materials for pharmaceutical, biomedical and environmental applications. Depending on the application, active chemical and biological materials may be processed from liquid dispersions into droplets and/or particle formulations. The disclosed system uses moderate gas pressures to atomize liquids into submicron-size droplets that are 10-1000 times smaller in diameter than commercial and research systems. This allows much gentler and rapid droplet-to-particle conversion, applying much smaller physical and chemical stresses on the processed materials than conventional techniques like spray drying, spray coating, spray freeze drying and other technologies. For example, the disclosed system can be used for an ultra-fine nebulization and delivery of viscous therapeutic oils including oils of medical cannabis, for which conventional nebulization systems either fail or became ineffective. Such systems could help patients with acute respiratory distress syndrome (ARDS) developed in hard COVID-19 cases.

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COMPOSITION COMPRISING GOLD NANOPARTICLE AS ACTIVE INGREDIENT FOR PREVENTION OR TREATMENT OF CORONA VIRUS-19

NºPublicación: WO2021206187A1 14/10/2021

Solicitante:

CHIN CHUR [KR]

US_2021308180_A1

Resumen de: WO2021206187A1

The present invention relates to a pharmaceutic composition comprising gold nanoparticles for treating or preventing corona virus infection. In the present invention, the gold nanoparticles prevent interfere with a morphological change of corona virus proteins to block the invasion of corona virus proteins into cells, thereby enabling the prevention or treatment of corona virus infections.

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METHOD FOR TRANSFORMING INHOMOGENEOUS AQUEOUS SOLUTIONS COMPRISING INORGANIC AND ORGANIC COMPONENTS INTO HOMOGENEOUS SOLUTION

NºPublicación: WO2021205289A1 14/10/2021

Solicitante:

INNOSTUDIO ZRT [HU]

Resumen de: WO2021205289A1

In many areas of life, it is necessary to prepare a homogeneous mixture from inorganic and organic salts which, under certain conditions, precipitate each other due to chemical reactions or other transformations, and thus it is impossible to prepare an aqueous solution having suitable ion composition in homogeneous form. The precipitation changes the composition of the solution and thus reduces its therapeutic or other usability. The compatibility problems can be reduced to some extent by converting the components in the solution into nanoparticles in the usual and known manner, however, according to the common experience, the nanoparticle formation alone is not sufficient to adequately solve the non-compatibility problems. The present invention provides a method for producing homogeneous solutions starting from organic and/or inorganic salts, which are non- compatible with each other.

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PREPARATION METHOD FOR MICRORNA MICRO/NANOSPHERES AND APPLICATION THEREOF IN HEALING SPINAL CORD INJURY

NºPublicación: WO2021203515A1 14/10/2021

Solicitante:

YAOSHUNZE BIO MEDICAL NANJING CO LTD [CN]

CN_111437268_A

Resumen de: WO2021203515A1

Disclosed is a method for preparing microRNA micro/nanospheres, comprising: preparing a micro/nanosphere solution of polylactic acid-hydroxyethanoic acid copolymer via a re-emulsification process; adding an aqueous solution of polyetherimide into the micro/nanosphere solution of polylactic acid-hydroxyethanoic acid copolymer, followed by shaking and mixing until uniform to form a micro/nanosphere complex solution of polylactic acid-hydroxyethanoic acid copolymer modified by polyetherimide; and loading different microRNAs on the micro/nanospheres to form microRNA micro/nanospheres complex. Micro-nanospheres of polylactic acid-hydroxyethanoic acid copolymer, which is a biopolymer, are combined to regulate the expression of a variety of microRNAs, so as to form a local microenvironment that is conducive to regeneration after spinal cord injury, thereby promoting the healing process after spinal cord injury.

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HEPARIN NANO DRUG CARRIER SYSTEM FOR LOADING AMINO ANTI-TUMOR DRUG, AND PREPARATION METHOD THEREFOR

NºPublicación: WO2021203959A1 14/10/2021

Solicitante:

NANJING KING FRIEND BIOCHEMICAL PHARMACEUTICAL CO LTD [CN]
KINDOS PHARMACEUTICALS CO LTD [CN]

CN_112121174_A

Resumen de: WO2021203959A1

Disclosed in the present invention is a heparin nano drug carrier system for loading an amino anti-tumor drug. The drug carrier system is a conjugate for loading the amino anti-tumor drug on a PEGylated heparin molecule. A natural polysaccharide heparin that is biodegradable and has good compatibility and high availability is used as a drug carrier, and, by means of combining PEG modification and the amino anti-tumor drug, as compared with free drugs, nanoparticles have a significantly enhanced anti-tumor therapeutic index and biological safety in in-vivo therapy.

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NANO MATERIAL FOR OSTEOCLAST ACIDIC CLOSED REGION AND PREPARATION METHOD THEREFOR

NºPublicación: WO2021203434A1 14/10/2021

Solicitante:

SIR RUN RUN SHAW HOSPITAL ZHEJIANG UNIV SCHOOL OF MEDICINE [CN]

Resumen de: WO2021203434A1

Disclosed are a nano material for an osteoclast acidic closed region and a preparation method therefor. The nano material for an osteoclast acidic closed region comprises a nano material, bone-targeting molecules and a compound which causes an osteoclast acidic closed region to undergo a chemical reaction. After the nano material is subjected to bone targeting molecular modification, a compound which causes an osteoclast acidic region to undergo a chemical reaction is entrapped; and osteoclasts are inhibited by means of accurate mature osteoclast targeting and a biological cascade reaction regulated by a physiological chemical reaction. A new way of thinking and a new tool are provided for the pharmaceutical treatment of abnormal osteoclast activation.

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NANOPARTICLES FOR USE IN PHOTODYNAMIC THERAPIES AND METHODS OF MAKING, EVALUATING AND USING THE SAME

NºPublicación: WO2021207742A1 14/10/2021

Solicitante:

MI2 HOLDINGS LLC [US]

US_2021316011_A1

Resumen de: WO2021207742A1

A nanocomposition for use in treating a pathogen condition using phthalocyanine dye, such as IR700. A nanocomposition having IR700, an 8PEG nanoparticle and a pathogen targeting peptide. Administering a product comprising IR700 to a patient, whereby the IR700 is delivered to pathogen tissue, and found in only pathogen tissue; and administering light to activate the IR700, thereby producing an ROS.

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SYNTHETIC LIVER-TROPIC ADENO-ASSOCIATED VIRUS CAPSIDS AND USES THEREOF

NºPublicación: JP2021527405A 14/10/2021

Solicitante:

ザユニバーシティオブノースカロライナアットチャペルヒルTHEUNIVERSITYOFNORTHCAROLINAATCHAPELHILL

US_2021246467_A1

Resumen de: WO2019241324A1

The invention relates to synthetic adeno-associated virus capsids targeted to the liver and virus vectors comprising the same. The invention further relates to methods of using the vectors to target the liver and provide liver-specific expression, as well as transduce human primary hepatocytes and cell lines.

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SCAFFOLDS WITH STABILIZED MHC MOLECULES FOR IMMUNE-CELL MANIPULATION

NºPublicación: JP2021527419A 14/10/2021

Solicitante:

ダンマークステクニスクユニバーシテットDANMARKSTEKNISKEUNIVERSITET

BR_112020024183_A2

Resumen de: WO2019243463A1

The present invention relates to artificial antigen presenting cell (aAPC) scaffolds to provide cells with specific functional stimulation to obtain phenotypic and functional properties ideal to mediate tumor regression or viral clearance. In particular, the scaffolds of the present invention comprise stabilized MHC class I molecules comprising a heavy chain comprising an alpha-1 domain and an alpha-2 domain connected by a disulfide bridge, wherein said MHC class I molecules are free of antigenic peptide. The scaffolds can be loaded with antigenic peptide on demand, providing an agile platform for effective expansion and functional stimulation of specific T cells in a peptide- MHC-directed fashion.

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Peptide conjugated particles

NºPublicación: JP2021165273A 14/10/2021

Solicitante:

ノースウェスタンユニバーシティ

KR_20210096312_A

Resumen de: CN104684578A

The present invention provides compositions comprising peptide-coupled biodegradable poly(lactide-co-glycolide) (PLG) particles In particular, PLG particles are surface-functionalized to allow for coupling of peptide molecules to the surface of the particles (e.g., for use in eliciting induction of immunological tolerance).

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PLATINUM-BASED AMPHIPHILE PRODRUGS

NºPublicación: JP2021527675A 14/10/2021

Solicitante:

ナノメッドホールディングスプロプライエタリーリミテッド

US_2021275489_A1

Resumen de: WO2019241853A1

The present invention relates to platinum (IV) prodrug lipid-based amphiphiles and compositions thereof. In particular, it relates to cisplatin, oxaliplatin and carboplatin prodrugs with the capacity to make stable liquid crystalline nanoparticles and crystalline nanoparticles, and uses thereof to treat cancer in animals, including human.

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APPARATUS, SYSTEMS, AND METHODS FOR CONTINUOUS MANUFACTURING OF NANOMATERIALS AND HIGH PURITY CHEMICALS

NºPublicación: JP2021527561A 14/10/2021

Solicitante:

デルファイサイエンティフィック、エルエルシー

US_2020397696_A1

Resumen de: WO2019246615A1

A method for continuously processing at least two liquid feed streams is provided. A system for continuously processing at least two liquid feed streams is also provided.

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Nonviral modification of t cell gene expression

Nº publicación: AU2020260280A1 14/10/2021

Solicitante:

PREC NANOSYSTEMS INC

WO_2020210901_A1

Resumen de: AU2020260280A1

There is provided a lipid mix composition comprising ionizable lipid, a structural lipid such as DSPC, a sterol, and a surfactant such as polysorbate 80, polyoxyethylene (10) stearyl ether, polyoxyethylene (20) stearyl ether, or D-α-Tocopherol polyethylene glycol 1000 succinate. The lipid mix compositions find particular use in transfecting difficult to transfect cells and maintaining the viability of those cells. The lipid mix compositions are particularly well suited to T cell transfection

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