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Resultados 78 resultados LastUpdate Última actualización 14/05/2021 [01:58:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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Preparation of live vaccines

NºPublicación: CN112760252A 07/05/2021

Solicitante:

瑞士伊兰科动物保健有限公司

ES_2776429_T3

Resumen de: AU2013311675A1

Described is a method for the generation of a live vaccine containing stable bacteria carrying at least three attenuating mutations and a vaccine containing bacteria obtained by said method.

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METHODS OF TREATMENT OF INFECTIONS USING BACTERIA

NºPublicación: CN112770764A 07/05/2021

Solicitante:

迪科生物系统公司

AU_2019347502_A1

Resumen de: US2020101119A1

The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non-viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines.

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TUMOR-TARGETING SALMONELLA GALLINARUM STRAIN AND USE THEREOF

NºPublicación: WO2021086085A1 06/05/2021

Solicitante:

CHOYBIOLAB CO LTD [KR]
UNIV NAT CHONNAM IND FOUND [KR]

Resumen de: WO2021086085A1

The present invention relates to a tumor-targeting Salmonella gallinarum strain and the use thereof. The tumor-targeting Salmonella gallinarum strain has excellent tumor proliferation inhibitory activity and enables tumor-specific targeting, and thus can be utilized for treatment and imaging of tumors without any side effects.

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METHODS FOR DETECTING MICROORGANISMS USING MICROORGANISM DETECTION PROTEIN AND OTHER APPLICATIONS OF CELL BINDING COMPONENTS

NºPublicación: CN112740041A 30/04/2021

Solicitante:

美国控股实验室公司

CA_3093277_PA

Resumen de: WO2019173838A1

Disclosed herein are methods and systems for rapid detection of microorganisms using a cell binding component (CBC). The specificity of CBSs for binding microorganisms allows targeted and highly specific detection of a microorganism of interest.

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BIOACTIVE HYDROXYAPATITE MATERIALS WITH ANTIBACTERIAL PROPERTIES

NºPublicación: RO134884A2 29/04/2021

Solicitante:

INSTITUTUL NAT DE CERCETARE DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 [RO]

Resumen de: RO134884A2

The invention relates to bioactive antibacterial materials based on zinc-doped hydroxyapatite, to be used for coating implants made of Ti6Al14V alloy and Mg alloy. According to the invention, the materials consist of Zn-doped hydroxyapatite, with a thickness ranging between 200 nm and 1 μm, with a Zn amount ranging between 3...12%, the percentage being expressed by mass, with the Ca/P ratio ranging between 1.61...1.83 and the crystal size of maximum 16 nm, the materials showing a good adhesion to the substrate, having the normal critical forces at the scratch adhesion test ranging between 8...18 mN, being hydrophilic, the contact angle being <40°, having a higher resistance to corrosion in simulated body fluid SBF with a pH = 7.4 at a temperature of 37°C, having a porosity of <0.1% and a corrosive attack protection efficiency Pe >86%, showing higher biomineralisation properties after 21 days of immersion in SBF, PBS or DMEM, recording a maximum weight gain of 2.1 mg, the biodegradation rate assessed by weight loss being of maximum 0.1 mg after immersion in SBF for 21 days and a good resistance to Staphylococcus aureus, Streptococcus pyogenes and Salmonella Typhimurium attack.

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Enhanced Shigella-Enterotoxigenic E. coli multi-valent vaccine

NºPublicación: US2021121553A1 29/04/2021

Solicitante:

UNIV MARYLAND [US]

BR_112020020377_A2

Resumen de: US2021121553A1

The invention relates to a multivalent Shigella/Enterotoxigenic Escherichia coli vaccine for use in prophylaxis and treatment of diarrheal disease. The Shigella-ETEC vaccine provides increased coverage of a broader range of ETEC and Shigella isolates than prior vaccines, and includes CS14 antigens and serotypes (S. flexneri 7a, or S. flexneri 1b).

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Vaccine, method of vaccination against clostridium difficile

NºPublicación: AU2019345141A1 29/04/2021

Solicitante:

THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIV
AVIEX TECH LLC

CA_3113432_A1

Resumen de: AU2019345141A1

An attenuated

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FLAGELLIN RELATED POLYPEPTIDES AND USES THEREOF

NºPublicación: US2021121520A1 29/04/2021

Solicitante:

CLEVELAND CLINIC FOUND [US]

US_2020261535_A1

Resumen de: US2021121520A1

The use of flagellin and flagellin related polypeptides for the protection of mammals from the effects of apoptosis is described.

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METHODS FOR MANUFACURING LIVE LACTOBACILLUS CELLS

NºPublicación: US2021121509A1 29/04/2021

Solicitante:

MICROBIOS INC [US]

US_2020078423_A1

Resumen de: US2021121509A1

Lactobacillus-based probiotic compositions for inclusion in microbial-based products. In one instance, the microbial-based product takes the form of an animal feed additive. When used as a feed additive for animals, especially ruminants, and in particular cattle, the following benefits from the composition are noted: (i) improved milk yield in dairy cattle, (ii) improved milk composition in dairy cattle, (iii) increased weight gain-to-feed intake ratio in beef cattle (feed efficiency), and (vi) improved average daily weight gain. Another marked benefit of the compositions when used as an animal feed additive is inhibition of pathogenic growth including E. coli, Salmonella, Clostridium, Staphylococcus and Streptococcus.

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ERADICATION OF BACTERIAL BIOFILM USING ANTI-AMYLOID MONOCLONAL ANTIBODIES

NºPublicación: US2021122809A1 29/04/2021

Solicitante:

UNIV TEMPLE [US]
LANKENAU INSTITUTE OF MEDICAL RES [US]

BR_112020024048_A2

Resumen de: US2021122809A1

The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.

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NOVEL VACCINE COMPOSITIONS

NºPublicación: WO2021074352A1 22/04/2021

Solicitante:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

EP_3808372_PA

Resumen de: WO2021074352A1

A Shigella flexneri O-antigen of a first serotype or subserotype are provided for use in raising an immune response against one or more Shigella flexneri O-antigen of a different serotype or subserotype, together with associated binding moieties, pharmaceutical compositions, kits, uses or methods.

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RECOMBINANT MODIFIED VACCINIA VIRUS ANKARA (MVA) FILOVIRUS VACCINE

NºPublicación: JP2021063112A 22/04/2021

Solicitante:

バヴァリアン・ノルディック・アクティーゼルスカブ

US_2020268872_A1

Resumen de: WO2016034678A2

The present invention relates to an improved filovirus vaccine comprising a recombinant modified vaccinia virus Ankara-based (MVA-based) vaccine against filovirus infection and to related products, methods and uses. Specifically, the present invention relates to genetically engineered (recombinant) MVA and FPV vectors comprising at least one heterologous nucleotide sequence encoding an antigenic determinant of a Marburg virus (MARV) or Ebola virus glycoprotein. Specifically, the invention relates to recombinant MVA comprising Ebola virus glycoprotein and virion protein 40. The invention also relates to products, methods and uses thereof as well as prime/boost regimens of MVA and genetically engineered (recombinant) FPV, e.g., suitable to induce a protective immune response in a subject.

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DEVICES, SYSTEMS, AND METHODS FOR THE DETECTION OF ANALYTES

NºPublicación: US2021116412A1 22/04/2021

Solicitante:

PROTEOSENSE [US]

US_2018299403_A1

Resumen de: US2021116412A1

Disclosed are devices, systems, and methods for the rapid and accurate detection of analytes, including Salmonella.

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Synthetic binding agents for limiting permeation through mucus

NºPublicación: AU2019343952A1 22/04/2021

Solicitante:

MUCOMMUNE LLC
UNIV NORTH CAROLINA CHAPEL HILL

CA_3113059_PA

Resumen de: AU2019343952A1

Synthetic binding agents for reducing the fraction of targets that can permeate through mucus and/or freely divide, and methods of reducing mucosal permeation and/or free division of a target using these synthetic binding agents.

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Methods of treatment of infections using bacteria

NºPublicación: AU2019347502A1 22/04/2021

Solicitante:

DECOY BIOSYSTEMS INC

CN_112770764_A

Resumen de: AU2019347502A1

The present disclosure relates generally to compositions, dosage forms, and methods for preventing and treating infections. The compositions include intact and substantially non-viable Gram-negative bacterial cells which have been treated to reduce lipopolysaccharide (LPS)-associated endotoxin activity, which surprisingly have increased activity to trigger immune cell production of cytokines.

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COMPOSITIONS AND METHODS FOR PRODUCING ENHANCED IMMUNE RESPONSES AND RAPID ANTIBODY PRODUCTION

NºPublicación: WO2021076897A1 22/04/2021

Solicitante:

UNIV VIRGINIA PATENT FOUNDATION [US]

Resumen de: WO2021076897A1

Provided are modified bacteria and derivatives thereof that express antigens of interest. In some embodiments, the bacterium has a reduced genome and induces an enhanced immune response against the antigen of interest when administered to a subject as compared to an immune response that would have been induced by a bacterium of the same strain that has a full complement of genes. In some embodiments, the antigen is expressed on a surface of a bacterium. Also provided are method for producing antibody against antigens of interest, vaccine compositions, methods for vaccinating subjects, methods for treating cancers in subjects, methods for modulating inappropriate and undesirable immune response, methods for targeting materials in or on a human or animal that may be the cause of disease or otherwise undesirable phenotypes, and expression vectors for expressing antigens on the surface of reduced genome bacteria.

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NOVEL VACCINE COMPOSITIONS

NºPublicación: EP3808372A1 21/04/2021

Solicitante:

GLAXOSMITHKLINE BIOLOGICALS SA [BE]

WO_2021074352_A1

Resumen de: EP3808372A1

A Shigella flexneri O-antigen of a first serotype or subserotype for use in raising an immune response against one or more Shigella flexneri O-antigen of a different serotype or subserotype, together with associated binding moieties, pharmaceutical compositions, kits, uses or methods.

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NOVEL PD-L1 TARGETING DNA VACCINE FOR CANCER IMMUNOTHERAPY

NºPublicación: RU2019132253A 19/04/2021

Solicitante:

ФАКСИММАГ

BR_112019019251_A2

Resumen de: WO2018167290A1

The present invention relates to an attenuated strain of Salmonella comprising at least one copy of a DNA molecule comprising an expression cassette encoding PD-L1. In particular, the present invention relates to said attenuated strain of Salmonella for use in the treatment of cancer.

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DIAGNOSTIC CHIP FOR ANALYZING PRESENCE OF BACTERIA IN A SAMPLE

NºPublicación: GR20190100415A 16/04/2021

Solicitante:

NANOPLASMAS PRIVATE COMPANY [GR]

EP_3798320_PA

Resumen de: GR20190100415A

A bacterium capture microfluidic device for ultrafast and highly sensitive analysis of the presence of bacteria in a liquid sample. The analysis is based on capture and lysis of viable bacteria on antibodies functionalized and lyophilized on chip, DNA amplification and visual detection.

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ENGINEERED IMMUNOSTIMULATORY BACTERIAL STRAINS AND USES THEREOF

NºPublicación: CN112673092A 16/04/2021

Solicitante:

阿克蒂姆治疗有限公司

KR_20210030973_PA

Resumen de: WO2020014543A2

Provided are delivery immunostimulatory bacteria that have enhanced colonization of tumors, the tumor microenvironment and/or tumor-resident immune cells, and enhanced anti-tumor activity. The immunostimulatory bacteria are modified by deletion of genes encoding the flagella or modification of the genes so that functional flagella are not produced, and/or are modified by deletion of pagP or modification of pagP to produce inactive PagP product. As a result, the immunostimulatory bacteria are flagellin- and/or pagP -. The immunostimulatory bacteria optionally have additional genomic modifications so that the bacteria are adenosine or purine auxotrophs. The bacteria optionally are one or more of asd -, purI - and msbB -. The immunostimulatory bacteria, such as Salmonella species, are modified to encode immunostimulatory proteins that confer anti-tumor activity in the tumor microenvironment, and/or are modified so that the bacteria preferentially infect immune cells in the tumor microenvironment or tumor-resident immune cells and/or induce less cell death in immune cells than in other cells. Also provided are methods of inhibiting the growth or reducing the volume of a solid tumor by administering the immunostimulatory bacteria.

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PRO-INFLAMMATORY AND ADJUVANT FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS

NºPublicación: JP2021059571A 15/04/2021

Solicitante:

ザチルドレンズメディカルセンターコーポレーション

JP_2021059570_A

Resumen de: WO2016115097A2

The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.

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PRO-INFLAMMATORY AND ADJUVANT FUNCTIONS OF TOLL-LIKE RECEPTOR 4 ANTAGONISTS

NºPublicación: JP2021059570A 15/04/2021

Solicitante:

ザチルドレンズメディカルセンターコーポレーション

JP_2021059571_A

Resumen de: WO2016115097A2

The present invention provides methods and compositions for specific activation of inflammatory responses in dendritic cells (DCs). 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphorylcholine (PAPC) and its oxidized variant (oxPAPC) were identified to promote DC-mediated immunity, and are provided as adjuvants in immunostimulatory compositions, including vaccines.

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ERADICATION OF BACTERIAL BIOFILM USING ANTI-AMYLOID MONOCLONAL ANTIBODIES

NºPublicación: EP3802572A1 14/04/2021

Solicitante:

UNIV TEMPLE [US]
LANKENAU INSTITUTE FOR MEDICAL RES [US]

US_2021122809_A1

Resumen de: WO2019226978A1

The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.

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一种基于鸡白痢沙门氏菌X蛋白包被的抗体ELISA检测方法

NºPublicación: CN112649606A 13/04/2021

Solicitante:

江苏立华牧业股份有限公司江苏兴牧农业科技有限公司

Resumen de: CN112649606A

本发明公开了一种基于鸡白痢沙门氏菌X蛋白包被的抗体ELISA检测方法,涉及家禽细菌性疾病检测领域;本发明通过制备和纯化鸡白痢沙门氏菌的SPF鸡源高亲和力多克隆抗体,采用免疫共沉淀技术筛选鉴定电子传递链中的电子载体、兼具氧化还原酶活性的优势抗原X蛋白;构建、表达并以特定温和方法纯化外分泌的优势抗原X蛋白;建立检测鸡白痢沙门菌抗体的间接ELISA方法。本发明能有效检出鸡白痢沙门菌阳性抗体,并提高了现有检测技术的特异性、灵敏性;为企业鸡白痢沙门氏菌净化提供了有力工具。

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沙门氏菌、鸭疫里默氏杆菌、大肠埃希氏杆菌病三联疫苗

Nº publicación: CN112618706A 09/04/2021

Solicitante:

青岛博霖生物科技有限公司

Resumen de: CN112618706A

本发明属于兽用生物制品技术领域,具体涉及一种沙门氏菌、鸭疫里默氏杆菌、大肠埃希氏杆菌病三联疫苗。抗原为灭活的鼠伤寒沙门氏菌S01株、鸭疫里默氏杆菌R01株和大肠埃希氏杆菌E01株。本发明的疫苗所使用的三种菌株毒力强高、免疫原性好并具有较好的交叉保护性。本发明制备的疫苗的安全性良好,未出现由疫苗引起的任何局部和全身不良反应。保存期试验中经过性状、安全性试验、效力试验数据的分析,各项指标均稳定有效;效力试验结果证明,三联灭活疫苗能产生良好抗体,并能产生较好的攻毒保护力。

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