SALMONELLA

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Resultados 75 resultados LastUpdate Última actualización 20/10/2021 [03:49:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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CAPTURE COMPOSITIONS

NºPublicación: US2021318298A1 14/10/2021

Solicitante:

SIENNA CANCER DIAGNOSTICS INC [US]

US_2018143188_A1

Resumen de: US2021318298A1

Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a Molecular Net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a Molecular Net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample. A Molecular Net may comprise a pseudorandom nature. Use of various capture molecules, linkers and spacers in a Molecular Net may confer unique binding properties to a Molecular Net. Porosity, binding affinity, size exclusion abilities, filtration abilities, concentration abilities and signal amplification abilities of a Molecular Net may be varied and depend on the nature of components used in its fabrication. Uses of a Molecular Net may include analyte capture, analyte enrichment, analyte purification, analyte detection, analyte measurement and analyte delivery. Molecular Nets may be used in liquid phase or on solid phases such as nanomaterials, modified metal surfaces, nanospheres, microspheres, microtiter plates, slides, pipettes, cassettes, cartridges, discs, probes, lateral flow devices, microfluidics devices, microfluidics devices, optical fibers and others.

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METHODS AND SYSTEMS FOR THE RAPID DETECTION OF LISTERIA USING INFECTIOUS AGENTS

NºPublicación: CN113490849A 08/10/2021

Solicitante:

美国控股实验室公司

CA_3126474_A1

Resumen de: WO2020160190A1

Disclosed herein are methods and systems for rapid detection of microorganisms such as Listeria spp. in a sample. A genetically modified bacteriophage is also disclosed which comprises an indicator gene in the late gene region. The specificity of the bacteriophage, such as Listeria-specific bacteriophage, allows detection of a specific microorganism, such as Listeria spp. and an indicator signal may be amplified to optimize assay sensitivity.

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NOVEL SALMONELLA-BASED CORONAVIRUS VACCINE

NºPublicación: WO2021198376A1 07/10/2021

Solicitante:

VAXIMM AG [CH]

Resumen de: WO2021198376A1

The present invention relates to a DNA vaccine comprising a Salmonella typhi Ty21a strain comprising a DNA molecule comprising a eukaryotic expression cassette encoding at least a COVID-19 coronavirus (SARS-CoV-2) spike (S) protein or a portion thereof. In particular, the present invention relates to the DNA vaccine for use in the prevention and/ or the treatment of coronavirus disease 2019 (COVID-19) or a SARS-CoV-2 infection.

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RECOMBINANT BACTERIA PRODUCING CHEMICALS INHIBITORY TO SALMONELLA INVASION

NºPublicación: WO2021202630A2 07/10/2021

Solicitante:

UNIV CORNELL [US]

Resumen de: WO2021202630A2

The present disclosure is directed to genetically modified bacteria that produce a diffusible signal factor (DSF). The disclosure also provides methods for treating or preventing Salmonella infection/invasion in a subject. The disclosure further provides vectors and compositions for carrying out the methods disclosed herein.

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METHOD FOR DETECTING MASTITIS-CAUSING BACTERIA

NºPublicación: EP3889609A1 06/10/2021

Solicitante:

ASAHI CHEMICAL IND [JP]

JP_WO2020111223_A1

Resumen de: EP3889609A1

An object of the present invention is to elucidate the cause of degradation of the reliability of detecting causative bacteria of environmental mastitis such as Escherichia coli, Klebsiella bacteria, Streptococcus bacteria, and CNS, and to provide a highly reliable detection means. Another object of the present invention is to provide a highly reliable detection means based on the immunochromatographic method, which enables quicker determination compared with the cultivation-based method, and a diagnosis kit using it. The present invention provides a method for detecting a causative bacterium of environmental mastitis of a livestock animal, which comprises: the step of determining whether number of the causative bacterium in a milk of a subject livestock animal is not smaller than a determination value defined beforehand on the basis of distribution of amounts of the causative bacterium in milks derived from a non-disease group and distribution of the amounts of causative bacterium in milks derived from a disease group by an immunological test method, and wherein the immunological test method is an immunochromatographic method using an antibody labeled with not less than 0.6/cm<2> and not more than 3.5/cm<2> of gold colloid particles (particle-labeled antibody).

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一种增强细菌中外源蛋白活性和表达的前导稳定元件

NºPublicación: CN113461790A 01/10/2021

Solicitante:

山西大学

Resumen de: CN113461790A

本发明属于生物技术领域,公开了一种增强细菌中外源蛋白活性和表达的前导稳定元件。为沙门氏菌肠亚种肠衣原体鼠伤寒菌株RM13672SspH1蛋白N端的208个氨基酸残基片段,其核苷酸序列如SEQ.ID.NO:1所示,氨基酸序列如SEQ.ID.NO:2所示。本发明得到的增强细菌中外源蛋白活性和表达的前导稳定元件,可以在工业界或科研中把它用作一个提升蛋白产量和蛋白活力的工具,有助于科学研究和生物医药工业生产以及抗传染病疫苗制备。此外,谷胱甘肽S转移酶(GST)是一个含有211个氨基酸的蛋白,是最常用的蛋白表达的稳定多肽,但对不同目标蛋白效果差异大。本发明鉴定出的SspH1前导稳定元件可以提供一个新的选择,以获得理想的活性蛋白的表达。

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METHODS FOR TESTING SKIN SAMPLES

NºPublicación: US2021302408A1 30/09/2021

Solicitante:

PROCTER & GAMBLE [US]

WO_2021189226_A1

Resumen de: US2021302408A1

A method of taking a skin sample can include placing an adhesive onto a portion of skin and lifting the adhesive from the skin. A skin sample may then be tested while still on the adhesive, for example, by inoculating the sample with a bacterium, fungus, virus, or a combination.

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METHOD FOR DETECTING MASTITIS-CAUSING BACTERIA

NºPublicación: JPWO2020111223A1 30/09/2021

Solicitante:

旭化成株式会社

EP_3889609_A1

Resumen de: WO2020111223A1

The purpose of the present invention is to find reliability degrading factors when detecting environmental mastitis-causing bacteria such as E. coli, Klebsiella, streptococcus and CNS and to provide a highly reliable detection means. Additionally, the purpose of the present invention is to provide: a highly reliable detection means by using immunochromatography that is capable of quicker determination than culture methods; and a diagnosis kit using the same. The present invention provides a method for detecting environmental livestock mastitis-causing bacteria, the method comprising an immunological test process for determining whether the number of the causal bacteria in the milk of a subject livestock is greater than a determination value that is set in advance on the basis of the distribution of the amount of noninfectious group-derived causal bacteria in the milk and the distribution of the amount of infectious group-derived causal bacteria in the milk, wherein the immunological test is immunochromatography that uses an antibody labeled with gold colloid particles (particle-labeled antibody) having sizes of 0.6-3.5/cm2.

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De-immunized shiga toxin A subunit effector polypeptides for applications in mammals

NºPublicación: JP2021151261A 30/09/2021

Solicitante:

モレキュラーテンプレーツ,インク.MOLECULARTEMPLATES,INC.

JP_2021129598_A

Resumen de: CN106414483A

The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins. The Shiga toxin effector polypeptides of the present invention have uses as components of therapeutics, diagnostics, and immunization materials. The cytotoxic proteins of the present invention have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections. The proteins of the present invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring the treatment of a variety of diseases, such as, e.g., cancers, immune disorders, and microbial infections.

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NEW STRATEGY TO TREAT AND PREVENT DISEASES CAUSED BY ENTEROBACTERIAE

NºPublicación: WO2021191274A1 30/09/2021

Solicitante:

INST NAT SANTE RECH MED [FR]
UNIV RENNES [FR]

Resumen de: WO2021191274A1

The present invention relates to the treatment of diseases induced by Enterobacteriae. The inventors evaluated, in a multicellular in vitro model associating cells representing human enterocytes (Caco-2 cells), goblet mucus secreting cells (HT29-MTX) and M cells, whether Bacteroides fragilis, a non-enterotoxigenic strain, could be useful to limit the severity of the Salmonella Heidelberg infection, with an hypermutator phenotype, by analyzing their impact on growth and mucosal translocation. Thus, the present invention relates to a Bacteroides fragilis strain for use in the treatment of diseases induced by Enterobacteriae in a subject in need thereof.

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METHODS FOR TESTING SKIN SAMPLES

NºPublicación: WO2021189226A1 30/09/2021

Solicitante:

PROCTER & GAMBLE [US]
WEI KARL SHIQING [US]
YUE FENG [CN]
YU HECHUAN [CN]

US_2021302408_A1

Resumen de: WO2021189226A1

A method of taking a skin sample can include placing an adhesive onto a portion of skin and lifting the adhesive from the skin. A skin sample may then be tested while still on the adhesive, for example, by inoculating the sample with a bacterium, fungus, virus, or a combination.

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ERADICATION OF BACTERIAL BIOFILM USING ANTI-AMYLOID MONOCLONAL ANTIBODIES

NºPublicación: JP2021525798A 27/09/2021

Solicitante:

テンプルユニヴァーシティ−オブザコモンウェルスシステムオブハイアーエデュケーションランケナウインスティテュートオブメディカルリサーチ

KR_20210095998_A

Resumen de: WO2019226978A1

The present invention features compositions comprising an anti-amyloid antibody and methods of treating microbial infection and treating or preventing microbial biofilms using the composition.

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EFFICIENT TRACELESS GENE EDITING SYSTEM FOR SALMONELLA AND USE THEREOF

NºPublicación: WO2021184763A1 23/09/2021

Solicitante:

JIANGSU TARGET BIOMEDICAL RES INSTITUTE CO LTD [CN]

CN_111454927_A

Resumen de: WO2021184763A1

Provided are an efficient traceless gene editing system for Salmonella and the use thereof. Double exchange between a template DNA and a genomic target site is promoted by means of using a λRed recombinase, and is combined with a CRISPR/Cas9 system, which is used as a screening means, and one-step homologous recombination to rapidly construct a targeting plasmid by means of which genes can be inserted, substituted or knocked out. Genomic DNA is completely substituted according to a designed homologous template, and no other fragments remain. Genome editing can be efficiently finished within 3-4 days, the experimental strength is alleviated, and the experimental period is shortened.

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A METHOD OF FEEDING MONOGASTRIC ANIMALS IN ORDER TO CONTROL THE PRESENCE OF BACTERIA IN THESE ANIMALS

NºPublicación: US2021289814A1 23/09/2021

Solicitante:

NUTRECO NEDERLAND BV [NL]

CA_3034378_A1

Resumen de: US2021289814A1

A method of controlling the presence of bacteria that belong to the group of enterobacteriaceae, for example, Salmonella and/or Escherichia species, in a monogastric animal, by feeding the monogastric animal with a feed material that comprises mycelium of Agaricus Blazei Murill (ABM mycelium), e.g., grown on a grain substrate.

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METHOD FOR DIAGNOSING INFECTION WITH HELICOBACTER SUIS

NºPublicación: US2021292375A1 23/09/2021

Solicitante:

THE KITASATO INST [JP]

JP_WO2019225639_A1

Resumen de: US2021292375A1

Described herein is a newly found outer membrane protein gene specific for Helicobacter suis and a gene product thereof. Also described herein is a method for determining infection of a subject with Helicobacter suis and a method for treatment using an antibody against the gene product.

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IMMUNE COMPOSITION, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

NºPublicación: US2021290759A1 23/09/2021

Solicitante:

BRAVOVAX CO LTD [CN]

AU_2019349036_A1

Resumen de: US2021290759A1

A prokaryotic expression system or a recombinant adenovirus system is used to highly efficiently express VZV envelope gE glycoprotein and the flagellin fusion protein thereof. The produced recombinant gE protein, gE flagellin fusion protein and recombinant adenovirus vector, or composition thereof is used to immunize a mouse so as to promote the body to generate gE and VZV-specific antibody titer, as well as gE-specific and VZV-specific cell immunity.

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MULTIPLE ANTIGEN PRESENTING IMMUNOGENIC COMPOSITION, AND METHODS AND USES THEREOF

NºPublicación: EP3881836A1 22/09/2021

Solicitante:

CHILDRENS MEDICAL CENTER [US]

KR_20210037018_PA

Resumen de: EP3881836A1

The present embodiments provide for an immunogenic multiple antigen presenting system comprising a polymer to which antigens are associated by complementary affinity molecules. For example, the polymer can be a polysaccharide, or antigenic polysaccharide, to which protein or peptide antigens from the same or different pathogens are indirectly linked. The present immunogenic compositions can elicit both humoral and cellular immune responses to one or multiple antigens at the same time.

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MODIFIED STRAIN OF SALMONELLA ENTERICA TYPHI

NºPublicación: CN113412122A 17/09/2021

Solicitante:

普罗卡瑞姆有限公司

AU_2020215254_A1

Resumen de: WO2020157203A1

The present invention relates to the modification of a live attenuated strain of Salmonella enterica serovar Typhi, wherein its natural surface-exposed polysaccharide and flagellin antigens may be converted to, or augmented by, those from other strains of Salmonella, including S. enterica serovars Paratyphi, Typhimurium and Enteritidis. The present invention also relates to modified strains of Salmonella enterica serovar Typhi being suitable for use as components of a vaccine for enteric fever and salmonellosis.

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DETOXIFIED LIPOPOLYSACCHARIDES (LPS), NATURALLY NON-TOXIC LPS, AND USES THEREOF

NºPublicación: WO2021180972A1 16/09/2021

Solicitante:

HEPHAISTOS PHARMA [FR]

Resumen de: WO2021180972A1

The invention relates to an enriched population of modified lipopolysaccharide (LPS) molecular species being: - devoid of phosphate group at position C1 of the reducing end of their lipid A domain; and - substituted at position C6' of the non-reducing end of their lipid A domain by a hydrophilic moiety, with the proviso that said hydrophilic moiety is not a hydroxyl group. It also relates to compositions comprising the enriched population of modified LPS; and uses of naturally-occurring LPS molecular species and/or enriched population of modified LPS molecular species for treating and/or preventing cancer, inflammatory diseases or infectious diseases, and for stimulating an immune response or vaccinating a subject.

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INDUCTION OF PROTECTIVE IMMUNITY AGAINST ANTIGENS

NºPublicación: US2021284955A1 16/09/2021

Solicitante:

UNIV FLORIDA [US]

MX_2019008645_A

Resumen de: US2021284955A1

Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation and/or regulated expression of one or more antigens of interest.

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FOOD SAFETY VACCINE TO CONTROL SALMONELLA ENTERICA AND REDUCE CAMPYLOBACTER IN POULTRY

NºPublicación: US2021283235A1 16/09/2021

Solicitante:

UNIV FLORIDA [US]

BR_112019015425_A2

Resumen de: US2021283235A1

Described herein are compositions and methods for making and using recombinant bacteria that are capable of regulated attenuation, regulated expression of one or more antigens of interest, and/or N-glycan modification of secreted/surface antigens.

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METHOD AND DEVICE FOR DETECTION OF AMPICILLIN-RESISTANT NON-TYPHOIDAL SALMONELLA

NºPublicación: US2021285028A1 16/09/2021

Solicitante:

UNIV TAIPEI MEDICAL [TW]

TW_202024341_A

Resumen de: US2021285028A1

Disclosed is a method and a device for determining whether a sample contains ampicillin-resistant (AMP-R) non-typhoid Salmonella (NTS). The method comprises detecting, in the sample, the presence of a combination of certain genes or their gene products, wherein the presence of said combination indicates the sample contains AMP-R NTS.

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MICROBIAL COMPOSITIONS AND USES THEREOF

NºPublicación: WO2021181210A1 16/09/2021

Solicitante:

WHITE DOG LABS INC [US]

Resumen de: WO2021181210A1

Provided are microbial compositions comprising at least one attenuated form of a pathogenic bacterium having an ability to colonize at least one organ of the gastrointestinal tract of an animal, such as an attenuated form of a bacterium having an antagonistic effect against a bacterium selected from the group consisting of Salmonella enteritidis, Salmonella enterica, Salmonella typhimurium, Clostridium difficile, Clostridium perfringens, Escherichia coli, Campylobacter spp., Listeria monocytogenes, Yersinia enterocolitica and combinations thereof. Also provided are animal feeds comprising such compositions, preparations for in-ovo injection comprising such compositions and methods of treatment using such compositions.

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ENGINEERED SALMONELLA SEROVAR TYPHIMURIUM STRAINS, COMPOSITIONS THEREOF, AND METHODS OF USE

NºPublicación: US2021283234A1 16/09/2021

Solicitante:

UNIV NORTH CAROLINA STATE [US]

WO_2018022974_A1

Resumen de: US2021283234A1

Provided herein are engineered Salmonella enterica serovar Typhimurium strains and compositions, including vaccines, thereof. Also provided herein are methods of treating and/or preventing infection by at least Salmonella enterica serovar Typhimurium in a subject in need thereof by administering a vaccine provided herein.

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DIAGNOSING SEPSIS OR BACTEREMIA BY DETECTING PEPTIDOGLYCAN ASSOCIATED LIPOPROTEIN (PAL) IN URINE

Nº publicación: EP3877762A1 15/09/2021

Solicitante:

MICHEL LEA [US]
HELLMAN JUDITH [US]

WO_2020097499_A1

Resumen de: WO2020097499A1

A method, device and kit for detecting sepsis or bacteremia in a patient includes detecting peptidoglycan associated lipoprotein (Pal) from Gram-negative bacteria in the urine of the patient is disclosed.

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