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Resultados 150 resultados LastUpdate Última actualización 05/02/2023 [12:19:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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一种3D打印的平面导板

NºPublicación: CN115670704A 03/02/2023

Solicitante:

杭州深蓝维笑医疗科技有限公司

Resumen de: CN115670704A

本发明涉及平面导板技术领域,尤其涉及一种3D打印的平面导板。包括平面导板,所述平面导板包括口内弓、口外板和口侧板,所述口内弓呈“Y”字形,所述口内弓与口外板固定连接,所述口外板的两侧分别固定连接一个口侧板,所述两个口侧板和一个口外板呈“U”字形,所述口侧板远离口外板的一侧设置固位块。设计了一种3D打印的平面导板,可对平面导板的大小进行调节,且设置有固位块,可对平面导板进行固定,提升了稳定性。

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METHOD AND SYSTEM FOR MANUFACTURING AN ORTHOPAEDIC SPLINT AND ORTHOPAEDIC SPLINT THEREOF

NºPublicación: FR3125700A1 03/02/2023

Solicitante:

SKINCASTS [FR]

Resumen de: WO2023006987A1

The invention relates to a method for manufacturing an orthopaedic splint, wherein the splint is made up of two non-identical foam (8) shells (3, 4) made of plastic, the two shells (3, 4) extending substantially longitudinally and being intended to be wrapped around a patient's limb (2), the shells (3, 4) being connected to one another by a plurality of attachments, wherein the method comprises a subsequent step of thermoforming the two shells (3, 4) during which the two shells (3, 4) are put in place around the patient's limb (2) and at least one portion of at least one of the two shells (3, 4) is heated at a temperature of between 40°C and 70°C in a way that the shape of the portion is modified strictly within the circumferential limits of the two shells (3, 4).

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BONE REPAIR SCAFFOLD, AND PREPARATION METHOD THEREFOR AND USE THEREOF

NºPublicación: CN115671384A 03/02/2023

Solicitante:

中国科学院深圳先进技术研究院

WO_2023000371_PA

Resumen de: WO2023000371A1

A bone repair scaffold, and a preparation method therefor and the use thereof. The bone repair scaffold is a three-dimensional porous scaffold, and the material of the bone repair scaffold comprises the following components in percentage by mass: 80-95% of a biodegradable polymer and 5-20% of a biodegradable nanoparticle, wherein the biodegradable nanoparticle is a nanoparticle of a manganese compound. The method for preparing the bone repair scaffold comprises: preparing a homogeneous solution containing the biodegradable polymer and the biodegradable nanoparticle according to the mass percentages; preparing a formed three-dimensional porous scaffold from the homogeneous solution by using a curing process; and freeze-drying the formed three-dimensional porous scaffold to obtain the bone repair scaffold. The bone repair scaffold can better promote the healing of a bone injury and has excellent mechanical properties and good medical imaging functions.

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基于TPMS结构的锌合金或其复合材料组织工程支架及制备

NºPublicación: CN115671380A 03/02/2023

Solicitante:

天津理工大学

Resumen de: CN115671380A

本发明属于医用材料制备技术领域,涉及一种基于TPMS结构的锌合金或其复合材料组织工程支架及制备方法。本发明的方法步骤如下:1)建模得到多孔支架的STL数据。2)导入3D打印机,设置,打印得到多孔珠宝树脂支架。3)灌注石膏溶液,使石膏溶液完全侵入多孔支架的内部,一同干燥烧结,得到多孔石膏支架的翻模体。4)采用渗流铸造法在多孔石膏支架翻模体中渗流锌合金或其复合材料。5)超声清洗支架内部的石膏,得到本发明所述支架。本发明解决了目前3D打印技术无法直接制备锌合金及其复合材料多孔支架的问题,实现了低孔径、高孔隙率的锌合金及其复合材料的多孔支架的制备,实现了锌合金及其复合材料的多孔支架结构孔径及孔隙率的精确控制。

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一种多肽和双生长因子梯度分布的含细胞骨软骨支架及其制备方法和应用

NºPublicación: CN115671397A 03/02/2023

Solicitante:

上海大学

Resumen de: CN115671397A

本发明提供了一种多肽和双生长因子梯度分布的含细胞骨软骨支架及其制备方法和应用,属于再生医学技术领域。本发明利用微流控通道对第一生物墨水、第二生物墨水和第三生物墨水的分散和汇聚过程,沿软骨下骨层方向,纳米羟基磷石灰浓度呈梯度逐渐变大,促进人骨髓间充质干细胞的矿化和诱导其分化为成骨细胞;转化生长因子和人骨形态发生蛋白沿骨‑软骨界面的垂直方向呈相反方向的浓度梯度分布,以梯度方式刺激人骨髓间充质干细胞的定向成骨分化和成软骨分化;精氨酸‑甘氨酸‑天冬氨酸多肽沿着软骨下骨层和关节软骨层呈反向的梯度浓度分布,实现人骨髓间充质干细胞在骨软骨界面的定向成骨分化和成软骨分化,以便更好地对缺损的骨软骨组织进行修复。

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一种3D打印仿生角膜缘移植物及其制备方法和用途

NºPublicación: CN115671398A 03/02/2023

Solicitante:

首都医科大学附属北京同仁医院

Resumen de: CN115671398A

本发明提供的一种3D打印仿生角膜缘移植物及其制备方法和用途,其仿生角膜缘移植物包括相互叠置的角膜缘上皮层和角膜缘微环境层,并通过分别基于LESC细胞,以及角膜缘基质干细胞、黑色素细胞和微血管内皮细胞配置的生物墨水,再经过3D打印制备获得。本发明提供的3D打印仿生角膜缘移植物及其制备方法和用途通过将3D生物打印技术重建角膜缘的立体结构,并将其用于角膜缘移植,进而达到治疗角膜缘干细胞缺乏,促进角膜上皮愈合,减少角膜组织的瘢痕形成,提高视力的目的。

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一种锆铌合金骨科植入物的三维制造方法

NºPublicación: CN115673339A 03/02/2023

Solicitante:

西安赛隆增材技术股份有限公司

Resumen de: CN115673339A

本公开实施例是关于一种锆铌合金骨科植入物的三维制造方法。该方法包括:建立目标工件的三维模型,三维模型分两部分进行设计:致密体部分和非致密体部分;设计致密体部分,并将致密体部分按照预设摆放形态进行摆放,得到摆放后的致密体部分,并在摆放后的致密体部分的底部设计若干拉杆单元;设计非致密体部分,并将非致密体部分与摆放后的致密体部分按照预设连接方式进行连接,得到连接后的致密体部分与非致密体部分的结合体;对结合体进行逐层离散处理,得到离散数据,并将离散数据及三维成形工艺参数导入三维成形设备;通过三维成形设备对锆铌合金粉末进行三维成形,得到目标工件。

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一种新型3D生物活性骨修复材料的制备

NºPublicación: CN115671385A 03/02/2023

Solicitante:

艾威亚(广州)医药科技有限公司

Resumen de: CN115671385A

本发明创新地将3D打印与相分离结合,构建了微米级的纤维状粗糙表面和纳米级微孔的PLA多孔支架。通过对PLA多孔支架表面包被聚多巴胺并滴加微球溶液,使微球粘附于支架表面,形成新型3D生物活性骨修复材料,用在大鼠颅骨中,可见明显的骨缺损修复。本发明利用相分离原理,采用有机溶剂四氢呋喃(THF)溶解3D打印的PLA,使PLA材料表面形成纤维样微观形貌。纳米或微米级的纤维形貌有利于干细胞及成骨细胞粘附生长,这对骨缺损修复起着重要的作用。

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NEURAL NETWORK-BASED GENERATION AND PLACEMENT OF TOOTH RESTORATION DENTAL APPLIANCES

NºPublicación: CN115697243A 03/02/2023

Solicitante:

3M\u521B\u65B0\u6709\u9650\u516C\u53F8

WO_2021240290_A1

Resumen de: WO2021240290A1

Techniques are described for automating the design of dental restoration appliances using neural networks. An example computing device receives transform information associated with a current dental anatomy of a dental restoration patient, provides the transform information associated with the current dental anatomy of the dental restoration patient as input to a neural network trained with transform information indicating placement of a dental appliance component with respect to one or more teeth of corresponding dental anatomies, the dental appliance being used for dental restoration treatment for the one or more teeth, and executes the neural network using the input to produce placement information for the dental appliance component with respect to the current dental anatomy of the dental restoration patient.

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一种具有消毒功能的医疗3D打印用矫正模具

NºPublicación: CN115670702A 03/02/2023

Solicitante:

苏州无限三维科技产业有限公司

Resumen de: CN115670702A

本发明公开了一种具有消毒功能的医疗3D打印用矫正模具,包括上模具主体和连接杆,所述上模具主体呈半圆结构,所述上模具主体为中空结构,所述上模具主体的顶部安装有储物框,所述储物框的底部为敞口结构,所述储物框的顶部贯穿设置有插孔,所述插孔的内部嵌合安装有戳针,所述储物框的内部放置有一次性储液袋,且一次性储液袋位于戳针的下方,所述储物框的内表面贯穿设置有第一连接孔,所述上模具主体的底部安装有均匀分布的连接杆。本发明通过安装有上模具主体、储物框、插孔、戳针、一次性储液袋和第一连接孔,向下推动戳针,使其扎破一次性储液袋,此时消毒液会通过第一连接孔和第二连接孔进入到储物框的内部,进而达到消毒的目的。

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OSSEOINTEGRABLE IMPLANTS AND SCREWS COMPRISING STRUCTURALLY POROUS SURFACE, PROCESS FOR PREPARING THE IMPLANTS AND SCREWS AND USES THEREOF

NºPublicación: CN115697253A 03/02/2023

Solicitante:

M3\u533B\u7597\u4EA7\u54C1\u8D38\u6613\u548C\u5065\u5EB7\u4EA7\u4E1A\u53CA\u53E3\u8154\u76F8\u5173\u6709\u9650\u516C\u53F8

WO_2021243429_A1

Resumen de: WO2021243429A1

The present invention relates to implantable medical devices (dental and orthopedic) (osseointegrable implants) textured by the additive manufacturing process. Such implants are prepared in such a way as to comprise a larger surface area of contact between implant/adjacent tissues, porous microstructure with complex geometry with controlled and diversified pore size, which confers several technical advantages. In addition, the present invention relates to the process of preparing said implants and/or screws with an optimized structure for accelerating osseointegration. Finally, the present invention refers to the use of said implants as carriers of drugs or cells in order to treat the site, promote its healing, tissue regeneration or promote cell growth.

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A SKIN MICROBE SAMPLER AND RELATED METHODS

NºPublicación: CN115697209A 03/02/2023

Solicitante:

新加坡科技研究局

WO_2021251907_A1

Resumen de: WO2021251907A1

The invention relates to a skin microbe sampler comprising: a plurality of solid microneedles extending from a support surface, wherein the microneedles are dimensioned to penetrate the epidermis and/or dermis layer of the skin to obtain microbes residing in the skin. In particular, the microneedles comprise a cone shape that is substantially devoid o patterning on the surface of said cone shape. In another embodiment, the surfaces of the microneedles comprise an adhesion coating on their surfaces for enhancing adhesion of the microbes on the microneedles. Also provided are a method of sampling microbes residing in a skin, a method of making the microbe sampler, and a mold for making the microbe sampler. In particular, the method of making the microbe sampler comprises 3D printing the solid microneedles and/or molding the solid microneedles from a negative imprint of the solid microneedles.

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一种放疗定位膜3D打印定位架

NºPublicación: CN218420687U 03/02/2023

Solicitante:

广州市第一人民医院广州消化疾病中心、广州医科大学附属市一人民医院、华南理工大学附属第二医院

Resumen de: CN218420687U

本实用新型涉及医疗器械技术领域,公开了一种放疗定位膜3D打印定位架,包括头架,所述头架向上竖立地设置有呈水平拱门形状的定位栏,所述定位栏的上端设置有用于连接定位膜的托板,所述托板上设置有数个连接孔。一种放疗定位膜3D打印定位架定位操作简易,对比常规3D打印的方案来说制作时间更短,根据患者的体表数据来重建设计,打印制作出来完全符合患者的体表以及骨性标志的位置,固定制化程度高,并且实际使用中直接置于患者定位位置固定,所以操作简易。

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一种单晶硅空心微针结构

NºPublicación: CN218420647U 03/02/2023

Solicitante:

苏州揽芯微纳科技有限公司

Resumen de: CN218420647U

本实用新型提供了一种单晶硅空心微针结构,属于微纳加工技术领域。本实用新型由(100)型双面抛光硅片加工而成,包括A部分和B部分;A部分与B部分一体连接;A部分为楔形结构,A部分具有贯穿第一面和第三面的贯穿孔;B部分具有贯穿槽,贯穿槽为倒四棱台凹槽;A部分第三面与B部分的贯穿槽的一个敞开口端连接;贯穿孔轴线垂直第三面且穿过贯穿槽,贯穿槽的侧壁与B部分底面之间具有角度。本实用新型的单晶硅空心微针结构在加工过程中仅用一次深硅刻蚀工艺,结合单晶硅各向异性腐蚀工艺,具有成本低、适合批量生产的优点,从而具高度产业利用价值。

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一种基于Jamming转变的可食用高稳定性乳液凝胶及其制备方法

NºPublicación: CN115669949A 03/02/2023

Solicitante:

甘肃农业大学

Resumen de: CN115669949A

本发明公开了一种基于Jamming转变的可食用高稳定性乳液凝胶及其制备方法。所述方法以质量浓度为4~8%的蛋白质和2~4%的多糖溶液为基质,按照体积比为9:1~4:6混合,利用超声技术构建水包水(W/W)型均相混合物,作为水相,以体积比为60~75%食用植物油脂为油相,通过超声联合均质技术将油相乳化,进而利用Jamming转变形成水包油(O/W)型乳液凝胶。所述W/W型蛋白质‑多糖混合液的构建改变了多糖结构,使其能够更好地填充在油滴间隙,增加了油滴间斥力,显著提高了乳液凝胶的稳定性,贮藏660天后仍保持结构完好和品质稳定。所述乳液凝胶构建工艺简单易行,产品稳定性高,通用性强,可作为脂肪替代物、活性因子载体、3D/4D打印食品等新型材料,应用前景广泛。

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METHOD AND SYSTEM FOR MANUFACTURING AN ORTHOPAEDIC SPLINT AND ASSOCIATED ORTHOPAEDIC SPLINT

NºPublicación: FR3125699A1 03/02/2023

Solicitante:

SKINCASTS [FR]

Resumen de: WO2023006972A1

The invention relates to a method for manufacturing an orthopaedic splint, the splint being made up of two non-identical cellular (8) plastic shells (3, 4), the two shells (3, 4) extending substantially longitudinally and being intended to partially envelop a patient's limb (2), the shells (3, 4) being connected to one another by a plurality of fasteners, wherein, during the course of the aforesaid digitization step, a plurality of three-dimensional sensors is applied to the patient's limb (2), the sensors, during the step of defining the shape and dimensions of the two shells (3, 4), determining the circumferential limits of each of the two shells (3, 4).

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OPERATIVELY TUNING IMPLANTS FOR INCREASED PERFORMANCE

NºPublicación: US2023034795A1 02/02/2023

Solicitante:

SMITH & NEPHEW INC [US]

US_2020219626_A1

Resumen de: US2023034795A1

A method for preoperatively characterizing an individual patients biomechanic function in preparation of implanting a prosthesis is provided. The method includes subjecting a patient to various activities, recording relative positions of anatomy during said various activities, measuring force environments responsive to said patient's anatomy and affected area during said various activities, characterizing the patient's biomechanic function from said relative positions and corresponding force environments, inputting the measured force environments, relative positions of knee anatomy, and patient's biomechanic function characterization into one or more computer simulation models, inputting a computer model of the prosthesis into said one or more computer simulation models, and manipulating the placement of the prosthesis in the computer simulation using said patient's biomechanic function characterization and said computer model of the prosthesis to approximate a preferred biomechanical fit of the prosthesis.

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METHOD FOR PRODUCING AN IMPLANT FOR INSERTING INTO AN EYE, IN PARTICULAR FOR INSERTING INTO THE SCHLEMM'S CANAL OF AN EYE

NºPublicación: DE112021002241A5 02/02/2023

Solicitante:

AIXTENT GMBH [DE]

CN_115666446_PA

Resumen de: WO2021204312A2

The invention relates to a method for producing an implant, in particular for inserting into an eye and in particular for inserting into the Schlemm's canal of an eye, in which method first at least one region of a blank of the material of the implant is exposed to laser radiation and subsequently the exposed region is removed by a liquid (etched), leaving behind the implant, the blank being permeable to the laser radiation. The invention additionally relates to an implant, which is hollow-cylindrical and is permeable to liquid on opposite sides of the lateral surface of the cylinder, and also relates to an arrangement comprising an implant which has a rod-, spiral- or sleeve -shaped insertion aid that can be detachably connected to the implant.

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3D-Printed Implants And Methods For 3D Printing Of Implants

NºPublicación: US2023037200A1 02/02/2023

Solicitante:

DEPUY SYNTHES PRODUCTS INC [US]

Resumen de: US2023037200A1

A method of making an implantable device includes directing a projection of laser energy having a plurality of adjacent energy pixels on a build surface atop a bed of powder, thereby forming a layer of the implantable device. The directing step is repeated a plurality of times, in a layer-by-layer manner, such that a totality of the formed layers define at least a portion of the implantable device.

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CRANIOFACIAL IMPLANTS FOR NEUROPLASTIC SURGERY

NºPublicación: US2023032649A1 02/02/2023

Solicitante:

ACUMED LLC [US]

WO_2021173617_A1

Resumen de: US2023032649A1

Craniofacial implants for neuroplastic surgery structured for filling cranial bone voids in the skull designed, shaped and manufactured to address problems including cranioplasty failure, soft tissue thinning above the implant, overlying scalp atrophy leading to contour irregularities and/or scalp breakdown with exposure/infection, ineffective pre-fabricated shapes with sharp corners requiring manually bending or cutting the implants for proper form/shape, and additional operative time and anesthesia morbidity, and a need to spend time hand-trimming prong edges along the perimeter to ensure an absence of sharp edges and/or corners capable of injuring the scalp/soft tissue above, leading to chronic pain. The craniofacial implants for neuroplastic surgery are configured to have an improved shape absent corners, a smoother contour, a shape addressing co-existing soft tissue temporal deformity/atrophy, and/or a smoother, frictionless coating in order to prevent complications leading to suboptimal outcomes and implant removal by way of prior art implants.

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NANOFIBER SHEET, METHOD FOR USING SAME, AND METHOD FOR MANUFACTURING SAME

NºPublicación: US2023033405A1 02/02/2023

Solicitante:

KAO CORP [JP]

CN_114901883_PA

Resumen de: US2023033405A1

A nanofiber sheet has a nanofiber layer composed of an accumulation of nanofibers. The nanofiber sheet has a plurality of membrane-like regions which extend between the nanofibers. The membrane-like regions of the nanofiber sheet each contain a water insoluble polymer and a pigment. The water insoluble polymer contained in the membrane-like regions of the nanofiber sheet is different from a constituent member of the nanofibers. The nanofiber sheet is preferred because it has a plurality of membrane-like aggregate regions, each an aggregate of a plurality of membrane-like regions which are adjacent to each other via a fiber and it has a non-membrane-like region between the membrane-like aggregate regions adjacent to each other.

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Customized tibial trays, methods, and systems for knee replacement

NºPublicación: AU2021276381A1 02/02/2023

Solicitante:

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
MONOGRAM ORTHOPAEDICS INC

WO_2021236736_A1

Resumen de: AU2021276381A1

A tibial tray system for a resurfaced proximal portion of a tibia for a patient includes, for example, a tibial tray and at least one screw. The tibial tray includes a body having a superior portion, and an inferior tibia-engaging portion having a peripheral inferiorly-extending portion contactable with an underlying cortical bone and/or spaced apart from the underlying inner surface of the cortical of the tibia of the patient. In some embodiments in the total knee replacement, a greater portion of a shearing force acting transversely on the tibial tray and the resected portion of the proximal portion of the tibia of the patient is resisted by the at least one inferiorly-extending wall and the periphery of the resected proximal portion of the tibia compared to a portion of the shearing force being resisted along the center inferior surface of the tibial tray and the resected cancellous bone surface.

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PROCESS TO OBTAIN THREE-DIMENSIONAL BIODRESSING, THREE- DIMENSIONAL BIODRESSING OBTAINED AND ITS USE

NºPublicación: WO2023004480A1 02/02/2023

Solicitante:

IN SITU TERAPIA CELULAR LTDA [BR]

Resumen de: WO2023004480A1

The present invention refers to a process to obtain a three-dimensional (3D) biodressing comprising the steps of (a) isolating and culturing mesenchymal cells with human AB serum; (B) performing three-dimensional (3D) bioprinting using a biomaterial such as sodium alginate and cells obtained in step "a"; (c) putting at rest the 3D biodressing obtained after bioprinting; (d) covering the 3D biodressing with a 100 mM calcium chloride solution; (e) washing the 3D biodressing; (f) adding Dulbecco's Modified Eagle Medium (DMEM); and (g) keeping the biodressing in an incubator for up to 15 days. Additionally, the present invention refers to the 3D biodressing obtained comprising, preferably 4% sodium alginate and mesenchymal cells from the umbilical cord (MCUs), which has healing, anti-inflammatory, and analgesic properties. Furthermore, the present invention relates the 3D biodressing to treat patients with chronic wounds and severe burns.

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3D-PRINTED IMPLANTS AND METHODS FOR 3D PRINTING OF IMPLANTS

NºPublicación: WO2023007304A1 02/02/2023

Solicitante:

DEPUY SYNTHES PRODUCTS INC [US]

US_2023037200_PA

Resumen de: WO2023007304A1

A method of making an implantable device includes directing a projection of laser energy having a plurality of adjacent energy pixels on a build surface atop a bed of powder, thereby forming a layer of the implantable device. The directing step is repeated a plurality of times, in a layer-by-layer manner, such that a totality of the formed layers define at least a portion of the implantable device.

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THREE-DIMENSIONAL TUMOR MODEL OF GLIOBLASTOMA AND BRAIN METASTASIS, METHODS OF MANUFACTURING SAME AND USES THEREOF

Nº publicación: WO2023007500A1 02/02/2023

Solicitante:

RAMOT AT TEL AVIV UNIV LTD [IL]

Resumen de: WO2023007500A1

A three dimensional (3D) model of a glioblastoma tumor made of a synthetic material and a plurality of cell types, including malignant cells and non-malignant cells of the tumor. Methods of forming the 3D tumor model are also provided, as well as systems in which the 3D tumor model can be perfused and fluidly connected to a medium containing immune cells and/or other cells and factors present in the tumor's microenvironment. Methods utilizing the 3D tumor model or the system in, for example, personalized therapy, are also provided.

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