Resumen de: US2023086561A1

An implantable guide element comprises a main body formed from a biocompatible material. One or more grooved surface structures are provided on and/or within the main body, each grooved surface structure comprising one or more grooves for directionally guided growth of fibro-axonal tissue. At least one of the one or more grooved surface structures may form a channel along or within the main body, within which an electrode is disposed in spaced relationship from a wall of the channel along at least part of its length.

Resumen de: US2023085743A1

The present invention relates to a chamber environment controlling apparatus for a three-dimensional bioprinter including a printing chamber having an internal space in which printing is performed and which is defined by wall surfaces including sidewalls. The apparatus may include a temperature adjustor including a heater configured to heat the internal space of the printing chamber and an air circulator including an air guide portion extending from an outside of the printing chamber along a sidewall on one side and formed so that air flowing in through an inlet moves along an inside, is heated by the temperature adjustor, and is discharged into the internal space of the printing chamber through an outlet, a circulation fan configured to circulate air along the air guide portion, and a filter configured to filter the air circulating along the air guide portion.

Resumen de: US2023089253A1

A stabilized fabric composed of a mesh or a woven fabric is disclosed as are methods of their manufacture, the manufacture of medical devices made using a stabilized fibers and stabilized medical devices are all disclosed. Fabrics can be stabilized by several techniques including: using mechanical, chemical and/or energetic fasteners at warp and weft intersections in the weave; by using various weaving techniques and fibers. Meshes can be stabilized when properly dimensioned and arranged junctions and struts of the necessary properties are used. All of these stabilized fabrics can be made of synthetic polymer materials such as ultrahigh molecular weight PE or PP and expanded PTFE.

Resumen de: US2023086853A1

A method of making an annuloplasty implant includes forming first and second support rings arranged in a coiled configuration around an axial direction and forming at least part of the first and second support ring from a carbon fiber material. The first and second support rings can be formed by 3-D printing according to dimensions of a 3-D reconstruction of a heart valve.

Resumen de: US2023091952A1

A soil-based coupon having an electronically readable verification code printed thereon is used for verification of soil removal by a cleaning process. The coupon includes a soil overlay covering the verification code. The verification code is at least partially revealed by removal of all or part of the soil overlay during the cleaning process. If the data encoded in the verification code can be correctly decoded after completion of the cleaning process, the cleaning process can be verified. The soil overlay can be designed to match the application. The coupons may be used in a cleaning process verification procedure in which one or more computing devices analyze images of the verification codes to determine whether or not cleaning processes can be verified.

Resumen de: US2023089755A1

A support is coupled to an appliance to decrease warpage. The support may comprise a plurality of extensions coupled to the appliance to decrease warpage. The extensions can be coupled to the appliance at one or more of many locations, such as on an occlusal surface, a wall, an edge or an interior of the appliance. In some embodiments, the extensions are coupled to walls of the appliance such as a buccal wall and a lingual wall, and the extensions can be coupled to the walls of the appliance near edges of the walls, such as a gingivally facing edges of the walls that are oriented toward the gingiva when the appliance is worn.

Resumen de: US2023091071A1

The present invention provides a resin composition for stereolithography that excels in strength, toughness, and water resistance in the form of a shaped article. The present invention relates to a resin composition for stereolithography that comprises a urethanized (meth)acrylic compound (A), a (meth)acrylate compound (B) containing no urethane bond, and a photopolymerization initiator (C),the compound (A) being a urethanized (meth)acrylic compound (A-1) having a polymer structure, and/or a urethanized (meth)acrylic compound (A-2) having no polymer structure,the compound (A-1) having a weight-average molecular weight of less than 1,000,the compound (A-2) having a molecular weight of less than 1,000,the compound (B) comprising at least one selected from the group consisting of a (meth)acrylate compound (b-I) represented by general formula (I), and a (meth)acrylate compound (b-II) represented by general formula (II).

Resumen de: US2023091824A1

In an aspect, an extrusion printer is provided comprising a print head comprising one or more nozzles suited for 3D printing of a pharmaceutical product. A metering pump is coupled to the print head and is arranged to control a flow to said print head and an extruder device comprises an input arranged to receive a powder or pellet material. A three-way pressure valve is fitted between the metering pump and the extruder device to automatically distribute a constant output flow from the extruder to an input flow directed towards the metering pump and a remainder flow directed towards the overflow outlet.

Resumen de: US2023091499A1

A photocurable composition includes a photopolymerizable component and a photopolymerization initiator, in which a diluted solution (D1) obtained by diluting the photocurable composition with ethanol such that the content of ethanol is 99% by mass would satisfy the following Condition (X): the transmittance at at least one wavelength within the wavelength range of from 365 nm to 405 nm, measured at an optical path length of 1 cm, is from 1.0% to 70.0%.

Resumen de: US2023087107A1

A system and computer-implemented method for manufacturing an orthopedic implant involves segmenting features in an image of anatomy. Anatomic elements can be isolated. Spatial relationships between the isolated anatomic elements can be manipulated. Negative space between anatomic elements is mapped before and/or after manipulating the spatial relationships. At least a portion of the negative space can be filled with a virtual implant. The virtual implant can be used to design and manufacture a physical implant.

Resumen de: US2023091323A1

Compositions and methods for making biocompatible articles are provided. A method includes preparing a 3D printable mixture and depositing successive layers of the mixture in a predetermined pattern to form a porous biocompatible article. The predetermined pattern has a porosity suitable for a bone or cartilage scaffold. Associated 3D printable compositions and porous articles made from the described methods are also described. The preparing a 3D printable mixture can comprise conjugating an alkyne-terminated polymer to a peptide to form a peptide-containing composite, or providing a mixture that comprises a ceramic material and a binder, and wherein the 3D printable mixture comprises from 50 wt. % to 80 wt. % of the ceramic material.

Resumen de: US2023091230A1

A system for performing quality analysis for multidimensional printing. The system includes a multidimensional printer, wherein the multidimensional printer comprises a printing head, a printing surface, an axis system and a scale, wherein the scale is arranged to measure weight applied on the printing surface; and a control unit operatively coupled to the multidimensional printer. The control unit is configured to control the printing head to extrude a printing material, to produce a printed object on the printing surface, obtain, from the scale, a weight of the printed object, and store the weight of the printed object in a memory associated with the control unit, compare the weight with a reference weight of the printed object, and control the printing head to stop extrusion of the printing material when the weight is equal to or exceeds the reference weight.

Resumen de: US2023092285A1

The invention provides a solid-dosage-form printing apparatus comprising: i) a 3D printer suitable for printing solid-dosage-forms, said 3D printer comprising an interchangeable print head selected from the group consisting of: a fused deposition modelling print head, a semi-solid extrusion print head and a direct powder extrusion print head; ii) a build platform; iii) a balance for measuring the mass of the printed solid-dosage-forms, said balance being integrated into said build platform; and optionally iv) means for performing in-line near-infra-red and/or raman spectroscopy on the solid-dosage-form product; wherein said solid-dosage-form comprises at least one active-ingredient and at least one excipient. Further provided are methods of producing solid-dosage-forms using the apparatus, including computer-implemented methods.

Resumen de: GB2610835A

A method of forming a stochastic structure comprises the steps of selecting a parent structure which defines an array of unit cells. Each unit has a size, a geometry, a relative density and at least one node. An implicit function of an object or part of an object is placed at each node. The object has position (xcn, ycn, zcn), and extent (rxn, ryn, rzn) parameters or a shape defined by an equation having at least the parameters x, y and z. One or more of the parameters are randomised by applying a statistical distribution having a standard deviation σ, which controls at least one of the three dimensions (Fig. 6) where random values of each parameter are created. A Monte-Carlo array of unit cells representative of the stochastic structure is created. The randomised unit cells may form three-dimensional volume data comprising iso-surfaces which may be rendered or printed with an additive manufacturing process. The implicit function may be any one or a combination of an ellipsoid, sphere, polygon, minimal surface or triply periodic minimal surface. A gas turbine engine including said randomised structure is also disclosed.

Resumen de: WO2021230789A1

A bioprinter (1) comprising at least one printhead (4a, 4b, 4c) with nozzle (5), a printbed (20) onto which the printhead (4a, 4b, 4c) is arranged to print an ink, an ultrasonic sensor arrangement arranged at the printbed (20), a controller (7) arranged to control movement of the printhead/nozzle (4a, 4b, 4c; 5) and to perform calibration of the printhead/nozzle (4a, 4b, 5 4c; 5) based on information from the ultrasonic sensor arrangement.

Resumen de: EP4151407A1

The present invention addresses the problem of providing a body-mounted component, molded using a 3D printer, which has excellent flexibility, with which the occurrence of breakages and the like when bent is suppressed, and which has a comfortable fit, and a method for manufacturing the same. A body-mounted component according to the present invention is mounted around a joint of the body, and is characterized in that the body-mounted component is formed by means of a resin material for a 3D printer, and in that the tensile elongation at fracture of the resin material is at least equal to 200%. Further, the method for manufacturing the same is characterized by including: a step 1 of forming a powder of the resin material for the 3D printer into a thin layer; a step 2 of selectively shining laser light onto the formed thin layer to form a molded object layer obtained by sintering or melt-bonding resin particles contained in the powder; and a step 3 of laminating the molded object layers by repeating step 1 of forming the thin layer and step 2 of forming the molded object layer a plurality of times, in this order.

Resumen de: WO2022040538A1

There is disclosed a talus implant comprising a base having at least one hole and at least one pin. There is also a top comprising at least one hole and at least one pin, wherein the top is configured to be inserted into the base. At least one embodiment comprises a tibial implant comprising at least one post and at least one base coupled to the at least one post. Additionally, there is at least one pad coupled to the at least one base, wherein the at least one pad is selectively insertable into and removable from the at least one base. A method for fabricating a talus and tibial implant is disclosed and also a method for inserting a talus implant and a tibial implant into a patient having a damaged talus joint.

Resumen de: WO2022045796A1

Disclosed are a composition for forming a clear orthodontic appliance, a method for manufacturing a clear orthodontic appliance, and a clear orthodontic appliance manufactured by the method. The disclosed composition for forming a clear orthodontic appliance comprises: 100 parts by weight of a first photocurable compound represented by chemical formula 1; 35-75 parts by weight of a second photocurable compound represented by chemical formula 2; 15-65 parts by weight of a third photocurable compound represented by chemical formula 3; 5-40 parts by weight of a fourth photocurable compound represented by chemical formula 4; and 1-15 parts by weight of a fifth photocurable compound represented by chemical formula 5.

Resumen de: CN115814152A

本发明涉及一种具有定向排列纤维微结构的高强度互穿网络(IPN)水凝胶血管的制备方法，其包括：准备水凝胶血管的原材料，配制生物水凝胶溶液；采用3D打印或者模具灌注的方法，制备管状水凝胶血管；通过控制温度变化和蓝光照射实现IPN水凝胶的制备；将IPN水凝胶置于管状水凝胶风干的设备，采用限制性风干的方法处理定向排列纤维结构的生成，最后复水保存。本发明的方法，简便易行，选用生物源性水凝胶，利用3D打印技术制备，打印过程与互穿网络形成过程同时进行；在水凝胶内部自发形成的纤维结构增强了其在特定方向的强度。本发明的方法，除制备血管外，还可用于制备各种需要较大力学强度的生物组织，例如肌肉、韧带等，以进行体内或体外的研究。

Resumen de: US2021290434A1

A macular indentor for implantation on an eye of a patient includes a curved backbone extending from a first end to a second end and a raised pad coupled to the first end of the backbone. The raised pad extends inward from an inner face of the backbone such that, when the macular indentor is implanted on the eye, the raised pad applies pressure to the sclera of the eye which contacts the macula of the eye. The geometry of the backbone is configured to match the geometry of the eye.

Resumen de: CN115813615A

本发明属于骨科医疗器械相关技术领域，并公开了一种表面多孔的髋臼杯假体分区设计及成型方法，其包括：髋臼杯球形壳体的建模；髋臼杯球壳壳体的等分分区切割；多孔层在分区髋臼杯假体表面的一体化设计；分区髋臼杯假体的重组；半球形髋臼杯假体的构建；以及髋臼杯假体的3D打印制造。通过本发明，所形成的多孔层垂直于髋臼杯表面，因此其具有优异的力学性能；其具有完全互联的枝杆结构且不存在孤立的杆，避免了术后长期活动的过程中孤立杆的脱落引发的炎症甚至是重新翻修。此外，该多孔层可以是任意形状的多孔结构且非常便利地成形到髋臼杯表面上，可针对促进骨长入的孔径和孔隙率进行设计，并满足长寿命、高生物相容性髋臼杯假体植入物的需求。

Resumen de: CN115813507A

一种皮肤固定骨骼标志定位的3D打印经皮穿刺定位模板制作技术，本发明属于微创治疗领域，涉及3D建模及3D打印领域。利用3D建模软件及3D打印技术，制作个性化的穿刺模板，用以解决穿刺过程不确定危险性及放射性图像引导多次曝光使患者接受过多辐射的问题。

Resumen de: CN115814151A

本发明公开了一种3D打印骨植入物表面多级微米结构的制备方法，属于人工假体的技术领域。其具体包括如下步骤，S1、准备3D打印钛合金骨植入体，S2、预清洗，S3喷砂处理、S4酸蚀处理、S5、二次清洗，S6、碱处理，S7、三次清洗。本发明具有较好的亲水性并提高了生物活性。

Resumen de: WO2018193306A2

A system for forming a product with different size particles is disclosed. The system comprises at least one print head region configured to retain a first group of print heads configurable to additively print at least a first portion of the product with a first material and a second group of print heads configurable to additively print at least a second portion of the product with a second material. The described system may also comprise a processor configured to regulate the first group of print heads and the second group of print heads to distribute the first material and the second material. A method of making an object by ink jet printing using the disclosed system is also disclosed.

Resumen de: CN218642832U

本实用新型提供了一种用于牙种植体的一体式保护帽和种植体组件，一体式保护帽包括一体成型的底座、颈部连接结构和顶部连接结构；所述颈部连接结构包括第一凹槽；其中，所述底座的外形与酸蚀夹具适配，所述颈部连接结构连接所述底座和所述顶部连接结构，所述顶部连接结构用于连接种植体；所述第一凹槽围设在所述颈部连接结构与所述种植体的近端的抵接处，且所述第一凹槽与所述种植体的颈部相适配。本实用新型能够在对所述种植体的表面进行酸蚀的过程中很好地保护种植体的内部以及所述顶部连接结构，从而延长所述一体式保护帽的使用寿命，节约资源。