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Resultados 131 resultados LastUpdate Última actualización 03/10/2022 [09:42:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 15 días / Applications published in the last 15 days



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含肼屈嗪的高效抗肿瘤纳米载药体系及其制备方法

NºPublicación: CN115120573A 30/09/2022

Solicitante:

上海浙江大学高等研究院

Resumen de: CN115120573A

本发明公开了一种含肼屈嗪的高效抗肿瘤纳米载药体系(H‑NPs),所述载药体系是以通过ππ键结合后的肼屈嗪与阿霉素作为疏水核心,以葡聚糖作为亲水外壳。本发明的含肼屈嗪的高效抗肿瘤纳米载药体系可通过扩张肿瘤血管和调节TME,从而增加肿瘤部位的血管通透性、血液灌注、改善纳米颗粒在肿瘤内的富集和渗透、减少肿瘤乏氧,增加肿瘤对化疗药物阿霉素的敏感度,显著提高其抗肿瘤效果。

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一种基因工程化细胞膜涂层脂质体纳米囊泡及其制备与应用

NºPublicación: CN115120572A 30/09/2022

Solicitante:

福建医科大学孟超肝胆医院(福州市传染病医院)

Resumen de: CN115120572A

本发明提供一种基因工程化细胞膜涂层的脂质体纳米囊泡Adar1‑LNPs@mPD1及制备方法和应用。纳米囊泡的外层是PD1生物细胞膜构成,Adar1‑siRNA(siAdar1)负载到其脂质体的内核中。基因工程化细胞膜表面表达的PD1可与癌细胞上的PD‑L1蛋白结合,阻断相关免疫抑制通路;脂质体(LNP)纳米颗粒具有高的核酸负载效率及良好的生物相容性;siAdar1可以有效地沉默ADAR1的表达以诱导肿瘤炎症,使肿瘤对干扰素更加敏感。通过上述功能的有机整合,Adar1‑LNPs@mPD1可激活系统的抗肿瘤免疫,实现显著的肿瘤生长消退、远端肿瘤预防和有效抑制肺转移。

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一种药物组合物及其制备方法

NºPublicación: CN115120734A 30/09/2022

Solicitante:

集美大学

Resumen de: CN115120734A

本发明提供一种药物组合物,所述组合物包括硫酸多糖和小分子活性物质,其中所述硫酸多糖包覆所述小分子活性物质。该组合物可使得硫酸多糖与小分子活性物质产生协同作用,增强其生物活性,为新型小分子药物的研发和应用提供支持。

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TRANSDERMAL DELIVERY SYSTEM

NºPublicación: CN115135309A 30/09/2022

Solicitante:

B.A.I.\u5B9E\u9A8C\u5BA4\u6709\u9650\u8D23\u4EFB\u516C\u53F8

US_2021169818_A1

Resumen de: WO2021108151A2

The present invention relates to compositions and methods for transdermal delivery of molecules or active ingredients into skin layers underneath Stratum Corneum. In preferred embodiments, the compositions comprise delivery systems providing high transdermal delivery efficiency.

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METHODS FOR TREATING TUMORS

NºPublicación: CN115135346A 30/09/2022

Solicitante:

NH\u963F\u5409\u514B\u65AF\u6CBB\u7597\u516C\u53F8,
\u683C\u52D2\u8BFA\u5E03\u5C14\u5927\u5B66\u4E2D\u5FC3\u533B\u9662,
\u683C\u52D2\u8BFA\u5E03\u5C14\u963F\u5C14\u5351\u65AF\u5927\u5B66

US_2022249711_A1

Resumen de: WO2021019268A1

The disclosure relates to methods for treating tumors. In particular, the disclosure relates to a method of treating a tumor by ionizing radiations in a subject in need thereof, said method comprising the steps of: (i) injecting a first therapeutically effective amount of high-Z element containing nanoparticles as radiosensitizing agents in said subject in need thereof within a period between 2 and 7 days prior to the first irradiation of the tumor, (ii) injecting a second therapeutically effective amount of the same or different high-Z element containing nanoparticles within a period between 1 hour to 12 hours prior to the first irradiation of the tumor, and, (iii) irradiating the tumor of said subject with a therapeutically efficient dose of radiations; wherein said high-Z element containing nanoparticles are nanoparticles containing an element with an atomic Z number higher than 40 and said nanoparticles have a mean hydrodynamic diameter below 10 nm.

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NANOPARTICLES COMPRISING PRODRUGS STABILIZED BY ALBUMIN FOR TREATMENT OF CANCER AND OTHER DISEASES

NºPublicación: CN115135319A 30/09/2022

Solicitante:

流明生物科学公司

CA_3157484_PA

Resumen de: WO2021092225A2

The present invention provides pharmaceutical compositions comprising solid nanoparticles, wherein the solid nanoparticles comprise i) an effective amount of a therapeutically active agent, wherein the therapeutically active agent is a substantially water insoluble prodrug; and ii) a biocompatible polymer.

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一种核酸和化药共递送聚合物组合物、其制备方法和应用

NºPublicación: CN115120733A 30/09/2022

Solicitante:

中国医学科学院药物研究所

Resumen de: CN115120733A

本发明属于生物医学材料领域,公开了一种多肽修饰的核酸和化药共递送聚合物组合物、其制备方法和应用。具体公开了一种聚合物组合物,其中包含:(i)聚乙烯亚胺‑聚乳酸羟基乙酸共聚物,其由下式表示:PEIm‑PLGAn,(ii)多肽共价连接的聚乙二醇‑聚天冬氨酸,即Di‑PEG‑PLD。两种材料通过静电作用结合,实现了靶向和核酸药物与难溶性化药共载的功能组合。本发明还公开了制备聚合物组合物的方法以及聚合物组合物共载核酸药物和难溶性抗肿瘤药物的方法。

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CARRIER FOR CELL DELIVERY

NºPublicación: CN115135307A 30/09/2022

Solicitante:

株式会社

WO_2021131116_A1

Resumen de: JP2021098668A

To provide a carrier for cell delivery that can deliver an active ingredient to a cell and a living tissue with high reliability and has all of antioxidant activity, intracellular absorptivity, intracellular disintegration properties, stability and safety.SOLUTION: Provided is a carrier for cell delivery, the carrier comprising: a vitamin derivative capable of simultaneously activating an autophagy-related gene and a synthetic gene for cathepsin; a stimulus-responsive polymer-containing molecule; an emulsion stabilizer; an active ingredient; and a lipid. Since the active ingredient is enclosed in the carrier for cell delivery, the carrier can deliver the active ingredient to a cell and a living tissue with high reliability.SELECTED DRAWING: None

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IN VITRO AND IN VIVO GENE DELIVERY TO IMMUNE EFFECTOR CELLS USING NANOPARTICLES FUNCTIONALIZED WITH DESIGNED ANKYRIN REPEAT PROTEINS (DARPINS)

NºPublicación: CN115135335A 30/09/2022

Solicitante:

生物技术细胞和基因治疗公司

AU_2020415313_PA

Resumen de: WO2021129945A1

The present disclosure generally relates to therapies involving immune effector cells such as T cells engineered to express antigen receptors such as T cell receptors (TCRs) or chimeric antigen receptors (CARs). It is demonstrated herein that such antigen receptor-engineered immune effector cells may be generated in vitro/ex vivo as well as in vitro by delivering nucleic acid encoding an antigen receptor for genetic modification to cells using particles comprising the nucleic acid and a targeting molecule for targeting the immune effector cells, wherein the targeting molecule is a designed ankyrin repeat protein (DARPin). In particular, DARPins are described herein which are high-affinity binders for CDS binding to the CDS receptor on human and non-human primate (NHP) cells. Nanoparticles functionalized with CD8- targeting DARPins (CDS-DARPin) can deliver genes exclusively and specifically to human CD8+ T cells in vitro and in vivo.

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FORMULATED AND/OR CO-FORMULATED LIPOSOME COMPOSITIONS CONTAINING IDO ANTAGONIST PRODRUGS USEFUL IN THE TREATMENT OF CANCER AND METHODS THEREOF

NºPublicación: CN115135385A 30/09/2022

Solicitante:

纳米医疗有限公司

KR_20220100904_PA

Resumen de: WO2021096542A1

Formulated and/or co-formulated liposomes comprising IDO prodrugs and methods of making the liposomes are disclosed herein. The IDO prodrug compositions comprise a drug moiety, a lipid moiety, and linkage unit that inhibit IDO-1. The IDO prodrugs can be formulated and/or co-formulated into a liposome to provide a method of treating cancer, immunological disorders, and other disease by utilizing a targeted drug delivery vehicle.

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NANOPARTICLE SYSTEMS TO STIMULATE AND MAINTAIN IMMUNE SYSTEM RESPONSIVENESS AT TREATMENT SITES

NºPublicación: CN115135764A 30/09/2022

Solicitante:

弗莱德哈钦森癌症中心蒂达尔治疗公司

AU_2020417305_PA

Resumen de: WO2021138600A1

Nanoparticle systems that genetically modify monocytes/macrophages in vivo to (1) recruit additional immune cells to a treatment site; (2) remain activated at the treatment site providing an on-going stimulatory signal to other immune cells; and (3) secrete bispecific immune-cell engaging antibodies that bind antigens on cells of interest at the treatment site and also bind and activate the recruited immune cells to destroy the bound cell. The systems can also inhibit the activity of transforming growth factor beta (TGFβ).

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KIT FOR PREPARING NANOPARTICLE COMPOSITION FOR DRUG DELIVERY, COMPRISING POLYLACTIC ACID SALT

NºPublicación: CN115135310A 30/09/2022

Solicitante:

三养控股公司

BR_112022012118_PA

Resumen de: WO2021125805A1

The present invention relates to a kit for preparing a nanoparticle composition for drug delivery and, more specifically, to a kit for preparing a nanoparticle composition for drug delivery, which is designed to easily form a nanoparticle in which a drug is encapsulated by simply mixing an amphiphilic block copolymer, a cationic compound, a polylactic acid salt, and the drug that are the components of the kit.

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LIPID NANOPARTICLE COMPOSITIONS AND METHODS AS CARRIERS OF CANNABINOIDS IN STANDARDIZED PRECISION-METERED DOSAGE FORMS

NºPublicación: US2022304938A1 29/09/2022

Solicitante:

NANOSPHERE HEALTH SCIENCES INC [CA]

CA_3089686_A1

Resumen de: US2022304938A1

This disclosure teaches phospholipid nanoparticle compositions of cannabinoids formed from phospholipids and simpler lipids in an unfired sequential process that encapsulate a high concentration of cannabinoids, and create standardized precision-metered dosage forms of cannabinoids; yielding an increase cannabinoid transport across hydrophobic mucosa; increase the bioavailability of the cannabinoid 2-fold to 8-fold, decrease the dose of cannabinoids 2-fold to 8-fold less than an amount of cannabinoids needed to illicit the same therapeutic effect compared to raw and non-encapsulated cannabinoids; where the nanoparticle dynamic structure reduces the adverse effects of cannabinoids; and enable safe more efficacious cannabinoid therapy.

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CONJUGATES OF HETEROAROMATIC NITROGEN-COMPRISING COMPOUNDS

NºPublicación: US2022305129A1 29/09/2022

Solicitante:

ASCENDIS PHARMA AS [DK]

Resumen de: US2022305129A1

The present invention relates to conjugates of π-electron-pair-donating heteroaromatic nitrogen-comprising drugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said conjugates and the use of said conjugates as medicaments.

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Mitochondrial Performance Enhancement Nanoemulsion Method

NºPublicación: US2022304927A1 29/09/2022

Solicitante:

QUICKSILVER SCIENT INC [US]

US_11344497_B1

Resumen de: US2022304927A1

An aqueous, intra-oral, nanoemulsion blend is provided that enhances mitochondrial performance in mammals when orally administered. The blend includes at least two different monolayer surfactant bound particle components and at least one bilayer water-core liposome component. The blend optionally may include a micelle.

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SUPPOSITORIES COMPRISING CANNABINOIDS

NºPublicación: US2022304925A1 29/09/2022

Solicitante:

APIRX PHARMACEUTICAL USA LLC [US]

Resumen de: US2022304925A1

This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.

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CHITOSAN POROUS STRUCTURE-BASED MAGNETICALLY ACTUATED MICROROBOT

NºPublicación: US2022305243A1 29/09/2022

Solicitante:

BIOT KOREA INC [KR]
KOREA INST OF MEDICAL MICROROBOTICS [KR]

KR_20220055223_PA

Resumen de: US2022305243A1

The present invention relates to a porous structure-based magnetically actuated microrobot and a fabricating method therefor, wherein the porous structure-based magnetically actuated microrobot is based on a natural polymer having biocompatibility and biodegradability, so that the precise targeting of the porous microrobot through the attachment of magnetic nanoparticles and the drug and cell delivery using the porous microrobot can be attained.

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IMMUNE MICROBUBBLE COMPLEX, AND USE THEREOF

NºPublicación: US2022305139A1 29/09/2022

Solicitante:

IMGT CO LTD [KR]

CN_114340682_PA

Resumen de: US2022305139A1

Provided is an immune microbubble complex, and a use thereof. An immune-microbubble complex (IMC) according to the presently claimed subject matter includes microbubbles to which an antibody is conjugated, in which the microbubbles have excellent stability and excellent antibody binding strength, and it was confirmed that, when the immune-microbubble complex is treated with high-intensity focused ultrasound (HIFU), an anti-tumor effect is significantly increased and an immune-enhancing effect is exhibited. Therefore, the immune-microbubble complex according to the presently claimed subject matter is expected to increase the efficiency of delivering the conjugated antibody and be used in both diagnosis and treatment of cancer, and exhibit various functions in the field of immunotherapy, including a contrast effect, half-life improvement, improved drug delivery, a lymphocyte concentration effect, cancer immunotherapy and induction of immunotherapy using ultrasound.

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DNA ENCODED NANOPARTICLE VACCINE AGAINST HUMAN PAPILLOMAVIRUS, AND METHODS OF USE THEREOF

NºPublicación: WO2022204597A1 29/09/2022

Solicitante:

WEINER DAVID [US]
LIAW KEVIN [US]
KULP DANIEL [US]
TURSI NICHOLAS [US]
XU ZIYANG [US]

Resumen de: WO2022204597A1

Disclosed herein are nanoparticles comprising one or more Human papillomavirus (HPV) antigen and nucleic acid molecules encoding the same. Also disclosed herein is a method of treating a HPV infection or treating or preventing a disease or disorder associated therewith in a subject in need thereof, by administering the nanoparticles, or encoding nucleic acid molecules, to the subject.

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PERTUSSIS VACCINE

NºPublicación: WO2022204491A1 29/09/2022

Solicitante:

MODERNATX INC [US]

Resumen de: WO2022204491A1

The disclosure relates to pertussis nucleic acid vaccines, diphtheria nucleic acid vaccines, tetanus nucleic acid vaccines, and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

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USE OF PORPHYRIN NANOSTRUCTURES AS ANTIMICROBIAL AGENTS

NºPublicación: WO2022204074A1 29/09/2022

Solicitante:

LUNANO INC [US]

Resumen de: WO2022204074A1

Methods of reducing or inhibiting growth of microbes (viruses, fungi and/or bacteria, including multi-drug resistant bacteria) can be carried out by applying a formulation including porphyrin nanoparticles to a surface to impart a residue of the porphyrin nanoparticles on the surface. The applied porphyrin nanoparticles residue can reduce or inhibit growth of infectious microbes on the surface for an extended period of time such as for at least 24 hours, 2 days, one week, etc. The applied porphyrin nanoparticles have high antimicrobial activity under visible light and without visible light.

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POLYNUCLEOTIDE COMPOSITIONS, RELATED FORMULATIONS, AND METHODS OF USE THEREOF

NºPublicación: WO2022204270A1 29/09/2022

Solicitante:

RECODE THERAPEUTICS INC [US]

Resumen de: WO2022204270A1

Compositions of polynucleotide(s), pharmaceutical compositions thereof, and methods of use thereof are disclosed. A polynucleotide may encode for a cystic fibrosis transmembrane conductance regulator (CFTR) protein or a functional fragment thereof. The polynucleotide may be assembled with a lipid composition for targeted delivery to a cell or an organ, such as a lung cell or a lung of a subject. Methods for enhancing an expression or activity of CFTR protein in a cell are provided. Methods for treating a subject having or suspected of having a CFTR-associated condition are also provided.

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COMPOSITIONS AND METHODS FOR TARGETED SYSTEMIC DELIVERY TO CELLS

NºPublicación: WO2022204286A1 29/09/2022

Solicitante:

RECODE THERAPEUTICS INC [US]
UNIV TEXAS [US]

Resumen de: WO2022204286A1

Described herein are compositions, kits, and methods for potent systemic delivery to a cell of a subject. Also described herein are pharmaceutical compositions comprising a therapeutic or prophylactic agent assembled to a lipid composition. The lipid composition can comprise an ionizable cationic lipid, a phospholipid, and a selective organ targeting lipid. Further described herein are high-potency dosage forms of a therapeutic or prophylactic agent formulated with a lipid composition.

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NANOPARTICLE COMPOSITION FOR TARGETED PROTEIN DEGRADATION

NºPublicación: WO2022201063A1 29/09/2022

Solicitante:

COVABIND JOINT RES PRIVATE LIMITED [IN]

Resumen de: WO2022201063A1

The invention provides a nanoparticle proteolysis targeting chimeras used for selectively inducing degradation of a targeted protein. More particularly invention provides nanoparticle composition comprising compound of Formula (I), their use as medicinal agent and process of their preparation.

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NANO ARTIFICIAL ANTIGEN PRESENTING CELL, PREPARATION METHOD THEREFOR AND USE THEREOF

Nº publicación: WO2022199138A1 29/09/2022

Solicitante:

SHENZHEN INST ADV TECH [CN]

CN_113041342_A

Resumen de: WO2022199138A1

Disclosed in the present invention are a nano artificial antigen presenting cell, a preparation method therefor and the use thereof, wherein the nano artificial antigen presenting cell is formed by means of encapsulating nanoparticles with an antigen-loading dendritic cell membrane, the antigen-loading dendritic cell membrane is used as a shell, and the nanoparticles are used as a core. The nano artificial antigen presenting cell is prepared by means of encapsulating the nanoparticles with the antigen-loading dendritic cell (also referred to as a DC cell) membrane, and can effectively activate the proliferation and activation of tumor-associated effector T cells and promote the enrichment of the T cells at tumor sites, so that the effects of treating tumors and inhibiting the proliferation and activation of tumor cells are achieved.

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