Resumen de: CN115805702A

本发明公开了一种口腔正畸中用于精准粘接托槽的3D打印工具及方法，涉及口腔正畸技术领域。此工具是以软的3D打印原料制作的半包围式及开窗式的托槽定位导板。方法是首先生成患者牙部的数字化模型，在数字化模型上定位托槽粘接位置；然后围绕粘接托槽位置设计半包围式及开窗式的托槽定位导板；选择合适的3D打印原料打印所述托槽定位导板；将3D打印成的托槽定位导板佩戴在患者口内，再由托槽定位导板确定的空格位置进行患者口内托槽粘接；完成后将托槽定位导板撕掉。本发明通过影像学、3D打印技术、数字化设计的结合与应用，实现化繁为简，使口腔正畸固定矫治变得更科学、精确和便捷，降低投入成本、提高效率，应用前景广阔。

Resumen de: CN115804677A

本发明涉及医疗设备的技术领域，更具体地，涉及一种矫形装置。一种矫形装置，包括脊柱矫形模块：所述脊柱矫形模块通过物理方法利用三点或四点矫正规律对身体凸出的位置进行外部施加压力；智能检测模块：实时监控患者佩戴脊柱矫形支具的压力和温度情况；红外热疗模块：采用纳米石墨烯技术施加电压后释放远红外线；穴位刺激模块：所述穴位刺激模块向穴位施加低频电流和低频震动刺激。本发明脊柱矫形支具采用3D打印便于患者穿戴；而且通过上述模块的综合作用，本矫形装置便于检测患者穿戴脊柱矫形支具的压力数据以及温度数据并通过提醒装置提醒，而且便于监护人可远程掌握实时检测数据；能提升用户体验，并且刺激穴位，增强治疗效果。

Resumen de: US2018133955A1

Systems, methods, components, and materials are disclosed for stereolithographic fabrication of three-dimensional objects. A resin including particles dispersed in a binder system can be substantially transparent to light of a wavelength sufficient to cure at least one component of the binder system. A green object can be formed by activation light penetrating into each layer of a plurality of layers of the resin in a layer-by-layer process to crosslink, polymerize, or both, at least one component of the binder system in successive layers of the resin to one another. Through subsequent processing, the green object can be densified to form a metal object, a ceramic object, or a combination thereof.

Resumen de: WO2020005386A1

Systems and methods of simulating dental treatments are disclosed. A method may include capturing a first 2D image of a patients face, including the patients teeth, building a parametric 3D model of the patients teeth based on the 2D image, developing a simulated outcome of a dental treatment of the patients teeth by rendering the 3D model with the patients teeth in one or more positions and/or orientations corresponding to the treatment goals of the dental treatment plan, and rendering a second 2D image of the patients face with teeth according to a simulated outcome of the dental treatment plan. As noted herein, the dental treatment plan may include orthodontic and/or restorative elements. The simulated outcome may correspond to estimated outcomes and/or intended outcomes of the dental treatment plan.

Resumen de: CN115804865A

本发明提供一种用于半月板替代的3D打印支架及其制备方法，设计径向和周向排列纤维的半月板模型，将聚(ε‑己内酯)装入3D打印机的料筒中，进行熔融沉积成型3D打印，得到3D打印半月板支架；将3D打印半月板支架置入氢氧化钠溶液中进行表面处理；将处理后的支架放到半月板形状的模具中，向模具中加入含N‑丙烯酰甘氨酰胺、光引发剂2‑羟基‑2‑甲基苯基丙酮的水溶液，在紫外光下进行自由基聚合反应，得到用于半月板替代的3D打印支架。本方法可通过3D打印对半月板支架的内部结构进行仿生设计，3D打印聚(ε‑己内酯)框架模拟胶原用于抵抗拉伸载荷，氢键超分子聚合物高强度水凝胶用于抵抗压缩载荷，在构建半月板组织替代物方面具有巨大应用潜能。

Resumen de: WO2021146554A1

Lithography fabrication methods for producing polymeric microneedles, microprobes, and other micron-sized structures with sharp tips. The fabrication process utilizes a single-step bottom-up exposure of photosensitive resin through a photomask micro-pattern, with a corresponding change/increase in refractive index of the resin creating a meta-state waveguide within the resin which focuses down additional transmitted energy and forms a converging shape (first harmonic microcone). Energy is diffracted through the tip of the first harmonic microcone as a second harmonic beam to form a second converging shape (second harmonic shape) adjacent the first microcone, followed by additional tertiary harmonic microcones, which can be built upon these structures with application of additional energy.

Resumen de: CN115804673A

本发明涉及一种定制化的颌面修复体及其制备方法，包括以下步骤：患者术前接受颌面部CT断层扫描，获得CT数据以DICOM格式导入数字化外科辅助软件；患者和医生讨论手术方案，在所述数字化外科辅助软件中分离患者剥离区域，并进行模拟设计颌面修复体，所述颌面修复体在接骨处矩阵镂空出用于骨长入的规则多孔结构，获得3D设计模型；对所述3D设计模型进行修复后，以STL文件的格式导入三维打印软件中，打印材料为聚醚醚酮和双向磷酸钙混合形成的植入级丝材，通过喷头熔融挤出逐层打印定制化颌面修复体，进行3D打印，在温度不小于100℃之前拆除所述支撑柱，得到定制化的颌面修复体。该方法易于实现，可操作性强，具有极好的运用前景。

Resumen de: WO2023035767A1

A 3D multi-branch bionic stent, a preparation method therefor and an application thereof. The 3D multi-branch bionic stent comprises: a main fiber tube, one end of the main fiber tube being connected to at least two primary branch fiber tubes, and the end of each primary branch fiber tube being connected to a secondary branch fiber tube; the cross-sectional area of the main fiber tube is equivalent to the sum of the cross-sectional areas of all the primary branch fiber tubes connected thereto; and the tube wall of the main fiber tube, the tube walls of the primary branch fiber tubes and the tube walls of the secondary branch fiber tubes all have pore structures. The 3D multi-branch bionic stent can provide effective mechanical support for defective tissues, and an interconnected network framework thereof facilitates cellular directional arrangement, osmotic growth, and blood vessel and nerve growth, and also facilitates the transfer of nutritional substances and metabolic waste. The stent has low production costs and high production operability, and is highly flexible.

Resumen de: US2023079256A1

An Internet of Thing (IoT) device includes a body with a processor, a camera and a wireless transceiver coupled to the processor.

Resumen de: US2023080204A1

Adaptive graft assemblies and methods of manufacture and implantation are provided herein. In particular, such grafts can be 3D printed and can be defined as standard designs or patient-specific, external sheaths customized for specific vein graft dimensions following minimally/non-invasive vein mapping and computational modeling. The external sheath may include one or more layers of various biomaterials to produce customized biomechanical properties. The external sheath may be made to elute specific bioactive drugs allowing for pharmacologic prevention of adverse remodeling in addition to mechanical support. These customizable features may be tailored for each patient individually depending on specific medical history, including hypertension, diabetes, smoking history, anatomy or any pertinent patient attribute. These methods protect vascular grafts, specifically venous grafts, from immediate exposure to arterial pressure that can induce adverse remodeling and graft failure, thereby providing a precision medicine solution to cardiovascular bypass surgery.

Resumen de: US2023079330A1

A system and method for manufacturing custom fit artificial nails includes a 3D surface scanning module and a 3D printing module and use thereof. A central processing module is connected to the 3D surface scanning module and the 3D printing module and performs: operating the 3D surface scanning module to obtain an image of a user's hands/feet; processing the image to create an input 3D model of nails of the user; generating an output 3D model corresponding to artificial nails matching dimensions of the user's nails according to the 3D input model; operating the 3D printing module to manufacture artificial nails according to the output 3D model; and generating medical data by correlating the identified features of the user's nails with known medical conditions, in order to diagnose a medical condition of the user which is known to exhibit the identified features as a symptom. Alternatively, or additionally, medicinal ingredient may be included in the artificial nail to treat the medical condition of the user. Embedded devices, sensors or an RFID chip may be integrated into the artificial nail.

Resumen de: US2023078215A1

In one aspect, the present application provides a method for fabricating shell-shaped dental appliance, comprising: generating a first 3D digital model representing an assembly of a support and a shell-shaped dental appliance, where the support has a first surface that conforms to and clings to a second surface of the shell-shaped dental appliance; and using the first 3D digital model to control a device to discharge successive drops of at least one fluid phase and solidifiable appliance material and successive drops of at least one fluid phase and solidifiable support material to form the assembly slice by slice along a first direction.

Resumen de: US2023082358A1

Current approaches in small diameter vascular grafts for coronary artery bypass surgeries fail to address physiological variations along the graft that contribute to thrombus formation and ultimately graft failure. An interlayer drug delivery system can sustain delivery of heparin through the graft with a high degree of temporal and spatial control. A heparin-loaded gelatin methacrylate interlayer sits between a biohybrid composed of decellularized bovine pericardium and poly(propylene fumarate) and UV crosslinking is controlled via 3D printed shadow masks. The masks enable control of the resultant gelMA crosslinking and properties by modulating the incident light intensity on the graft. High doses of heparin have detrimental effects on endothelial cell function. When exposed to heparin in a slower, more sustained manner consistent with the masks, endothelial cells behave similarly to untreated cells. Slower release profiles cause significantly more release of tissue factor pathway inhibitor, an anticoagulant, than a faster release profile.

Resumen de: US2023080308A1

Method and system for establishing an initial position of a tooth, determining a target position of the tooth in a treatment plan, calculating a movement vector associated with the tooth movement from the initial position to the target position, determining a plurality of components corresponding to the movement vector, and determining a corresponding one or more positions of a respective one or more attachment devices relative to a surface plane of the tooth such that the one or more attachment devices engages with a dental appliance are provided.

Resumen de: US2023080331A1

In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.

Resumen de: US2023080643A1

There is provided a microneedle patch. The microneedle patch includes: a plurality of microneedles each having an upper end portion and a base portion and which are individualized from each other; and a base layer that is formed of a water-soluble material and includes linear portions that pass the base portions of the microneedles neighboring each other among the plurality of microneedles and are joined to the base portions of the microneedles neighboring each other.

Resumen de: US2023084657A1

The present invention relates to a method for manufacturing a prefabricated crown by processing and tabulating the type, size, material and color of prefabricated crowns for sub-gingival and supra-gingival, and actual and try-in crowns by a table system (1), and a prefabricated crown manufactured therefrom, and the method includes a first step (S100) of classifying a plurality of prefabricated crowns by type and size by a first module (5) of the table system (1); a second step (S110) of classifying the plurality of prefabricated crowns by color and material by a second module (7) of the table system (1); a third step (S120) of tabulating the type, size, color and material data of the prefabricated crowns classified in the first and second steps (S100, S110) by a third module (9) of the table system (1), and assigning an identification code to each data; a fourth step (S130) of manufacturing the tabulated plurality of prefabricated crowns; and a fifth step (S140) of inputting the measured type, size, color and material data of patient's tooth into a fourth module (11) of the table system (1) to select a prefabricated crown corresponding thereto.

Resumen de: US2023083655A1

An external breast prosthesis (12) includes a main body made from a polymer, the body having an inner surface (13) for coinciding with an outer chest surface of a person wearing the breast prosthesis and an opposing outer surface (14), wherein the main body includes multiple elongated thermal conductors (15) that extend from a position adjacent the inner surface of the breast prosthesis to a position adjacent the outer surface of the breast prosthesis.

Resumen de: US2023084447A1

A sterilization system with automated sterilization data processing and related methods. In one aspect, the sterilization system receives mechanical indicator values and chemical indicator values for the sterilization cycle. The system determines whether the mechanical indicator values and chemical indicator values for the sterilization cycle match predetermined criteria. In response to the mechanical indicator and chemical indicator values for the sterilization cycle matching predetermined criteria, the system automatically generates a sterilization record in accordance with the first sterilization cycle data and second sterilization cycle data, stores the sterilization record in a sterilization database, and prints a sterilization label for each sterilized item in the sterilization cycle. Each sterilization label includes a Quick Response (QR) code encoding information for sterilization cycle.

Resumen de: US2023084440A1

The present disclosure relates to food grade hydrogels containing probiotics and methods of their preparation. More particularly, this disclosure describes 3D printable edible hydrogels, freeze-dried 3D printed edible hydrogels, systems for their printing, as well as, methods of preparing food grade 3D printed, freeze dried hydrogel compositions. Beneficially, the 3D printed, freeze-dried hydrogel compositions are storage stable.

Resumen de: US2023081904A1

In some embodiments, apparatuses and methods are provided herein useful to providing data files associated with orthodontic appliances. In some embodiments, a system for providing data files associated with orthodontic appliances comprises a database, wherein the database stores the data files associated with the orthodontic appliances and a control circuit, wherein the control circuit is communicatively coupled to the database, a user device, and a printer, wherein the control circuit is configured to receive, from the user device, an indication of a selected orthodontic device, retrieve, based on the indication of the selected orthodontic device from the database, one of the data files associated with the orthodontic appliances, wherein the one of the data files associated with the orthodontic appliances corresponds to the selected orthodontic appliance, and transmit, to the printer, the one of the data files associated with the orthodontic appliances.

Resumen de: WO2021224816A1

A printing process of high resolution, preferably medical, devices with complex geometries is described, comprising the steps of: - printing a model (1) with a three-dimensional printing method by using a three-dimensional printer; said model (1) positive reproducing the medical device (10) to be made; - said model (1) being printed of a first water-soluble polymer (2) or aqueous solutions; - covering said model (1) with a layer of material (3) insoluble to a solution able to dissolve said first soluble polymer (2); said covering step making a shell of solid mold (7) provided with a surface comprising empty interstitial spots; - infiltrating an amount of water or aqueous solution into said solid mold through said empty interstitial spots so that to dissolve said model (1) and to make a mold cavity (8) negative reproducing said model (1); - infiltrating into the mold cavity (8), through the outer walls of said mold, a second liquid polymer (5); said material (3) having a melting temperature greater than the melting temperature of said second liquid polymer (5) and/or a difference in the Hildebrand solubility parameter greater than or equal to 2 cal1/2cm-3/2 with respect to that of said second liquid polymer (5); said step of infiltrating into the mold cavity (8) occurs by depositing the liquid polymer (5) on the outer walls of said mold (7); - removing said mold by releasing the product obtained and created in said second polymer (5).

Resumen de: US2022027526A1

Designing personalized oral irrigation may include a generated oral insert including a fluid inlet port, fluid nozzles, manifolds, and a tray configured to retain teeth. One variation of a design method may comprise the steps of displaying a graphical representation of the oral insert model, generating a geometry of the fluid nozzles based on oral scan data of a jaw, defining a tray surface that encloses the fluid nozzles based on the oral scan data, and generating a geometry of the manifolds that connect the fluid inlet port to the fluid nozzles on the graphical representation of the oral insert model. The manifolds are configured to provide a predetermined range of hydraulic pressures to each of the fluid nozzles.

Resumen de: US10902944B1

Systems and methods for designing and implementing patient-specific surgical procedures and/or medical devices are disclosed. In some embodiments, a method includes receiving a patient data set of a patient. The patient data set is compared to a plurality of reference patient data sets, wherein each of the plurality of reference patient data sets is associated with a corresponding reference patient. A subset of the plurality of reference patient data sets is selected based, at least partly, on similarity to the patient data set and treatment outcome of the corresponding reference patient. Based on the selected subset, at least one surgical procedure or medical device design for treating the patient is generated.

Resumen de: WO2018175897A1

Stemless components and fracture stems for joint arthroplasty, such as shoulder arthroplasty, are disclosed. Also, methods and devices are disclosed for the optimization of shoulder arthroplasty component design through the use of medical imaging data, such as computed tomography scan data.