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Resultados 218 resultados LastUpdate Última actualización 27/05/2020 [21:04:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days



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POLYETHYLENIMINE NANOPARTICLES AND METHODS OF USING SAME

NºPublicación: EP3654948A1 27/05/2020

Solicitante:

CHILDRENS HOSPITAL MED CT [US]
UNIV CINCINNATI [US]

WO_2019018320_PA

Resumen de: WO2019018320A1

Disclosed herein are nanoparticle compositions containing that may be created by functionalizing polyethylenimine (PEI) with fatty acids and carboxylate terminated poly(ethylene glycol) (PEG). The disclosed compositions may be delivered to an individual in need thereof via delivery into blood circulation, where the nanoparticle compositions show an exceptionally high specificity to the pulmonary microvascular endothelium with minimal targeting of other cell types in the lung, to provide delivery of therapeutic agents such as stabilized nucleic acids. Methods of using the compositions are also disclosed.

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DEVICES, SYSTEMS, AND METHODS FOR DELIVERY OF SOLID FORMULATIONS

NºPublicación: EP3654844A1 27/05/2020

Solicitante:

ABBOTT DIABETES CARE INC [US]

WO_2019018838_PA

Resumen de: WO2019018838A1

The disclosed technology provides delivery devices for therapeutic agents, where the delivery devices are configured to be worn on a patient's body, and where the delivery devices deliver a solid formulation of a therapeutic agent subcutaneously to the patient. The delivery devices may in one embodiment be part of an integrated system comprising both a solid formulation delivery device and an analyte sensing device.

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NANOSTRUCTURED AND BIOCOMPATIBLE BIOCATALYSTS FOR USE IN CANCER TREATMENT

NºPublicación: EP3654949A2 27/05/2020

Solicitante:

GOMEZ LOPEZ WENCESLAO [MX]

US_2020147029_A1

Resumen de: WO2019016723A2

Nanostructured and biocompatible biocatalysts an organic ligand either linear or branched to Pt, Cu, or Fe-based compounds, in II, III or IV oxidation state, having cytotoxic activity for use in the treatment of cancer in animals or humans.

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NANOPARTICLES, METHODS AND USES THEREOF

NºPublicación: EP3654947A1 27/05/2020

Solicitante:

MEMORIAL SLOAN KETTERING CANCER CENTER [US]

WO_2019018707_PA

Resumen de: WO2019018707A1

The present invention provides nanoparticle compositions in which individual nanoparticles comprise one or more dopant entities, as well as methods of making and using such nanoparticle compositions, and various compositions and/or technologies relating to such nanoparticle compositions, their production and/or their use.

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ANTIMICROBIAL ADHESIVE PROTEIN, ANTIMICROBIAL NANOPARTICLE, ANTIMICROBIAL COMPOSITION COMPRISING SAME NANOPARTICLE, AND PREPARATION METHOD FOR SAME COMPOSITION

NºPublicación: EP3656785A1 27/05/2020

Solicitante:

POSCO [KR]
POSTECH ACAD IND FOUND [KR]

KR_20200017539_A

Resumen de: EP3656785A1

The present invention relates to an antimicrobial adhesive protein, an antimicrobial nanoparticle, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition and, more particularly, to an antimicrobial adhesive protein in which an antibiotic peptide is linked to a mussel adhesive protein, a mussel adhesive protein derivative in which a tyrosine residue within the antimicrobial adhesive protein is modified with a catechol derivative, an antimicrobial nanoparticle including a metal capable of forming a coordinate bond with a derivative of the mussel adhesive protein and having intrinsic antimicrobial activity, an antimicrobial composition comprising the same nanoparticle, and a preparation method for the same composition.

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NANOPARTICLE COMPOSITIONS

NºPublicación: EP3655009A1 27/05/2020

Solicitante:

YISSUM RESEARCH AND DEVELOPMENT COMPANY OF THE HEBREW UNIV OF JERUSALEM LTD [IL]
UNIV INDIANA RES & TECH CORP [US]

WO_2019016819_PA

Resumen de: WO2019016819A1

Compositions comprising nanoparticles are described herein. At least a portion of the nanoparticles comprises a lipid and/or polymer which is water-insoluble, and an agent incorporated in the lipid and/or polymer. The nanoparticles are optionally associated with a surface of water-soluble particles which comprise a water-soluble compound. The polymer is optionally a polyanhydride. Further described herein are processes for preparing such compositions, comprising contacting a solution comprising the lipid and/or polymer dissolved in a non-aqueous solvent with an anti-solvent (in which the lipid and/or polymer and agent are insoluble) which is miscible with the non-aqueous solvent. Further described herein are uses of the compositions for nasal administration, and devices configured for nasal administration of the composition upon atomization.

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NOVEL NANOPARTICLES OF ANTIRETROVIRAL DRUGS, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF VIRAL INFECTIONS

NºPublicación: WO2020099547A1 22/05/2020

Solicitante:

CENTRE NAT RECH SCIENT [FR]
PASTEUR INSTITUT [FR]
UNIV PARIS SACLAY [FR]

EP_3653201_A1

Resumen de: WO2020099547A1

The present application relates to nanoparticles comprising an antiretroviral drug and chitosan and optionally one or more metal cation, their use for treating viral infections, their process of preparation and the pharmaceutical compositions comprising the same.

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TLR9-TARGETED THERAPEUTICS

NºPublicación: WO2020102382A1 22/05/2020

Solicitante:

H LEE MOFFITT CANCER CENTER AND RES INSTITUTE INC [US]
ANP TECH INC [US]

Resumen de: WO2020102382A1

Disclosed are compositions and methods for targeted treatment of TLR9-expressing cancers. In particular, disclosed herein are molecules or conjugates containing a TLR9 targeting ligand, such as a CpG oligodeoxynucleotide, and a cytotoxic nanoparticle that targets TLR9-expressing malignant cells. Also disclosed is a pharmaceutical composition comprising a molecule disclosed herein in a pharmaceutically acceptable carrier. Also disclosed is a method for treating a TLR9-positive cancer in a subject that involves administering to the subject a therapeutically effective amount of a disclosed pharmaceutical composition.

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HYDROPHOBICITY/HYDROPHILICITY-TUNABLE ORGANOSILOXANE NANO-/MICROSPHERES AND PROCESS TO MAKE THEM

NºPublicación: WO2020097717A1 22/05/2020

Solicitante:

SILICYCLE INC [CA]

Resumen de: WO2020097717A1

The present disclosure relates to hydrophobicity/hydrophilicity-tunable organosiloxane nano-/microspheres with or without actives/payloads and a one-pot surfactant-free versatile process to make them. The release can be controlled by adjusting the hydrophobicity/hydrophilicity of the organosiloxane nano-/microspheres. The process of preparation comprising i0) separately hydrolyzing one or more silica precursor in a hydrolytic media; i1) combining the pre-hydrolyzed precursors or i2) removing a part of or totality of volatile solvents or i3) preparing a dispersed phase comprising a hydrophilic solvent to provide a dispersed phase; emulsifying, in absence of a surfactant, the dispersed phase of the step i1), i2) or i3) in a continuous phase to provide a water in oil emulsion; i5) adding a condensation catalyst to the emulsion to provide said nano-/microspheres.

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PLANT TISSUE-DERIVED NANOPARTICLES AND FOOD POWDERS

NºPublicación: WO2020097739A1 22/05/2020

Solicitante:

PSIGRYPH INC [CA]

Resumen de: WO2020097739A1

Provided herein are nanoparticles including self-assembled cellular components derived from a homogenized plant tissue. Also provided are food powders and other related compositions. Methods for preparing such nanoparticles and food powders, as well as uses thereof in the treatment or prevention of diseases or disorders in a subject and/or as delivery vehicles are also described.

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PLANT TISSUE-DERIVED NANOFIBRES

NºPublicación: WO2020097740A1 22/05/2020

Solicitante:

PSIGRYPH INC [CA]

Resumen de: WO2020097740A1

Provided herein are nanofibres including self-assembled cellular components derived from a homogenized plant tissue. Methods for preparing such nanofibres, as well as uses thereof in the treatment or prevention of diseases or disorders in a subject and/or as delivery vehicles are also described.

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一种靶向的pH/酯酶双重响应的双药超分子纳米组装体及其制备方法

NºPublicación: CN111184701A 22/05/2020

Solicitante:

陕西科技大学

Resumen de: CN111184701A

本发明公开了一种靶向的pH/酯酶双重响应的双药超分子纳米组装体及其制备方法,属于生物医用高分子材料技术领域。本发明的制备方法,以单‑6‑脱氧‑6‑乙二胺‑β‑环糊精修饰的透明质酸和酯基键合的姜黄素‑顺铂为原料,利用β‑环糊精和姜黄素之间的主客体包合作用形成超分子聚合物;以超分子聚合物为原料,利用所述超分子聚合物的两亲性自组装形成亲水性透明质酸为壳层、疏水性姜黄素‑顺铂为内核的超分子纳米组装体。本发明的双药超分子纳米组装体,可实现药物的靶向递送,特异响应性释放以及协同的联合治疗,增强对肿瘤组织的治疗效果,降低对正常组织的毒副作用,解决了目前化疗药物利用率不高,缺乏靶向性,具有毒副作用的问题。

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STEM CELL-DERIVED EXTRACELLULAR VESICLES AND METHODS OF USE THEREOF

NºPublicación: WO2020102684A1 22/05/2020

Solicitante:

UNIV WASHINGTON [US]
SHEN HUA [US]

Resumen de: WO2020102684A1

Disclosed herein are bionanoparticles of adipose-derived stem cell extracellular vesicles, a tissue repair matrix comprising the bionanoparticles, and methods of use thereof for enhanced tendon healing.

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NANOEMULSION COMPOSITIONS HAVING ENHANCED PERMEABILITY

NºPublicación: WO2020102494A1 22/05/2020

Solicitante:

BLUEWILLOW BIOLOGICS INC [US]

Resumen de: WO2020102494A1

The present disclosure relates to nanoemulsion compositions with certain surfactant blend ratios that impart enhanced permeability. Such compositions are useful for topical, mucosal, vaginal, and intranasal applications and allow for the greater delivery of one or more active agents to the application site.

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COMPOSITIONS AND METHODS FOR COMPARTMENT-SPECIFIC CARGO DELIVERY

NºPublicación: WO2020102578A1 22/05/2020

Solicitante:

FLAGSHIP PIONEERING INNOVATIONS V INC [US]

Resumen de: WO2020102578A1

Fusosome compositions and methods are described herein.

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NANOPARTICLES AND USES THEREOF

NºPublicación: WO2020099869A1 22/05/2020

Solicitante:

LIVERPOOL JOHN MOORES UNIV [GB]

Resumen de: WO2020099869A1

The present invention relates to a nanoparticle comprising a polymer, α- Galactosylceramide (α-GalCer) and chitosan. The invention also relates to multivalent immunogenic compositions. The invention has particular use as a pulmonary vaccine.

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可延缓肿瘤生长的β-CD-PEG-G分子的合成及作为药物递送系统的应用

NºPublicación: CN111184702A 22/05/2020

Solicitante:

滨州医学院

Resumen de: CN111184702A

本专利合成了β‑环糊精‑PEG‑鸟苷(β‑CD‑PEG‑G)分子,该分子可在水中自组装形成带负电的球形聚集体,并且其能够在水溶液中稳定存在。该聚集体可包载阿霉素(Dox)形成β‑CD‑PEG‑G‑Dox纳米药,包封率为79±6.3%,而Dox从β‑CD‑PEG‑G‑Dox纳米药中释放时具有缓释性和pH响应性。除此之外,通过生物试验表明,β‑CD‑PEG‑G聚集体可以延缓肿瘤的生长,具有一定的抗肿瘤活性;同时β‑CD‑PEG‑G‑Dox纳米药可有效诱导肿瘤细胞凋亡,能够更好的发挥抗肿瘤作用。因此,β‑CD‑PEG‑G分子作为优异的药物载体具有重要的研究意义。

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RNA INTERFERENCE DELIVERY FORMULATION AND METHODS FOR MALIGNANT TUMORS

NºPublicación: WO2020102668A1 22/05/2020

Solicitante:

NITTO DENKO CORP [JP]

US_2020157540_A1

Resumen de: WO2020102668A1

This invention provides formulations for use in distributing RNAi molecules targeted to a human GST-π for treating a malignant tumor in a subject. The formulation can include nanoparticles composed of an ionizable lipid, a DSPE lipid, and additional lipids. A drug product can be made by lyophilization of the formulation. This invention further provides methods for ameliorating or treating a malignant tumor by administering a therapeutically effective amount of a formulation containing the RNAi agents.

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Antisense Therapies For Treating Cancer

NºPublicación: US2020157536A1 21/05/2020

Solicitante:

UNIV CALIFORNIA [US]

CN_110719790_A

Resumen de: US2020157536A1

The present invention provides methods for cancers associated with a TERT promoter mutation in a subject. In some embodiments, the methods comprise administering to the subject a therapeutically effective amount of an agent that specifically reduces or inhibits GA binding protein transcription factor beta subunit 1 long isoform (GABPBIL) expression or function.

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Compositions and methods for enhancing visual function

NºPublicación: AU2018365175A1 21/05/2020

Solicitante:

UNIV CALIFORNIA

US_2019169244_A1

Resumen de: AU2018365175A1

The present disclosure provides a method of restoring or enhancing visual function in an individual, the method comprising administering to the individual a nucleic acid comprising a nucleotide sequence encoding one or more of a medium wavelength cone opsin (MW-opsin), a long wavelength cone opsin (LW-opsin), and a short wavelength cone opsin (SW-opsin). One or more of the MW-opsin, LW-opsin, and SW-opsin is expressed in a retinal cell in the individual, thereby restoring or enhancing visual function.

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FORMULATION COMPRISING GLYCOPYRROLATE, METHOD AND APPARATUS

NºPublicación: US2020155506A1 21/05/2020

Solicitante:

VECTURA LTD [GB]

US_2017258762_A1

Resumen de: US2020155506A1

A method is disclosed for making a pharmaceutical composition for pulmonary administration comprising co-jet milling glycopyrrolate and magnesium stearate, wherein the co-jet milled glycopyrrolate and magnesium stearate is then subjected to a conditioning step which includes exposure of the co-jet milled glycopyrrolate and magnesium stearate to humidity. A composition made by this method is also disclosed.

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THERAPEUTIC NANOPARTICLES ENCAPSULATING TERPENOIDS AND/OR CANNABINOIDS

NºPublicación: US2020155469A1 21/05/2020

Solicitante:

GBS GLOBAL BIOPHARMA INC [CA]
UNIV OF SEVILLE [ES]

WO_2020094908_A1

Resumen de: US2020155469A1

Provided herein are terpenoid- and cannabinoid-encapsulating PLGA nanoparticles and pharmaceutical compositions comprising the nanoparticles. Further provided are methods of making and using the terpenoid- and cannabinoid-encapsulating PLGA nanoparticles for therapeutic purposes.

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MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS

NºPublicación: US2020155706A1 21/05/2020

Solicitante:

MODERNATX INC [US]

Resumen de: US2020155706A1

The invention relates to compositions including polynucleotides encoding polypeptides which have been chemically modified by replacing the uridines with 1-methyl-pseudouridine to improve one or more of the stability and/or clearance in tissues, receptor uptake and/or kinetics, cellular access by the compositions, engagement with translational machinery, mRNA half-life, translation efficiency, immune evasion, protein production capacity, secretion efficiency, accessibility to circulation, protein half-life and/or modulation of a cell's status, function, and/or activity.

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COMPOSITION FOR TREATING CANCER OR INHIBITING CANCER METASTASIS, INCLUDING TFG OR TFMG NANOPARTICLES

NºPublicación: US2020155644A1 21/05/2020

Solicitante:

KYUNGPOOK NAT UNIV IND ACADEMIC COOP FOUND [KR]

Resumen de: US2020155644A1

The present invention relates to a composition for preventing or treating cancer, a composition for inhibiting the metastasis of cancer, and the like, including TFG nanoparticles or TFMG nanoparticles, and more particularly, to a composition exhibiting effects of treating cancer, effects of inhibiting the metastasis of cancer, and the like by normalizing blood vessels inside a tumor.

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SULFUR- OR HEAVY ATOM-CONTAINING NANOPARTICLES, METHODS OF MAKING SAME, AND USES THEREOF

Nº publicación: US2020155710A1 21/05/2020

Solicitante:

UNIV CORNELL [US]

WO_2018191316_A1

Resumen de: US2020155710A1

Provided are sulfur- or heavy atom-containing silica or aluminosilica nanoparticles. A nanoparticle can have at least one dye molecule covalently bonded to the silica or aluminosilica matrix of the silica or aluminosilica nanoparticle, respectively. The nanoparticle may have a size, such as, for example, a longest dimension, of less than 10 nm. The silica or aluminosilica nanoparticle can be used in methods such as, for example, imaging methods and photodynamic therapy methods. The imaging methods can provide sub-diffraction limit resolution.

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