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Resultados 130 resultados LastUpdate Última actualización 30/09/2022 [11:42:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 15 días / Applications published in the last 15 days



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COMPOSITIONS AND METHODS OF DETECTING AND TREATING THROMBOSIS AND VASCULAR PLAQUES

NºPublicación: US2022305143A1 29/09/2022

Solicitante:

MICROVASCULAR THERAPEUTICS LLC [US]

JP_2022535862_A

Resumen de: US2022305143A1

The invention provides nanodroplets labeled with targeting ligands that are useful in the detection and treatment of vascular thromboses (e.g., fibrin clots) and vascular plaques, or related diseases and conditions, as well as methods of preparation and use thereof.

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LIPID NANOPARTICLE COMPOSITIONS AND METHODS AS CARRIERS OF CANNABINOIDS IN STANDARDIZED PRECISION-METERED DOSAGE FORMS

NºPublicación: US2022304938A1 29/09/2022

Solicitante:

NANOSPHERE HEALTH SCIENCES INC [CA]

CA_3089686_A1

Resumen de: US2022304938A1

This disclosure teaches phospholipid nanoparticle compositions of cannabinoids formed from phospholipids and simpler lipids in an unfired sequential process that encapsulate a high concentration of cannabinoids, and create standardized precision-metered dosage forms of cannabinoids; yielding an increase cannabinoid transport across hydrophobic mucosa; increase the bioavailability of the cannabinoid 2-fold to 8-fold, decrease the dose of cannabinoids 2-fold to 8-fold less than an amount of cannabinoids needed to illicit the same therapeutic effect compared to raw and non-encapsulated cannabinoids; where the nanoparticle dynamic structure reduces the adverse effects of cannabinoids; and enable safe more efficacious cannabinoid therapy.

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PROTEIN PRODUCING NANOLIPOSOMES AND USES THEREOF

NºPublicación: US2022304928A1 29/09/2022

Solicitante:

UNIV CALIFORNIA [US]

WO_2021055660_A1

Resumen de: US2022304928A1

Synthetic liposomal nanoparticles comprising a cell-free transcription and translation machinery, a plasmid encoding a cytokine, and a regulatable caged ATP molecule, as well as microparticles encasing the synthetic liposomal nanoparticles and methods of making and using the synthetic liposomal nanoparticles, are described herein. These liposomal nanoparticles may be used for the controlled release o a cytokine within a localized environment of, for example a tumor, as part of a therapeutic treatment of cancer, or for localized treatment at a focus of interest of an autoimmune disease, an allergic reaction or hypersensitivity reaction, a localized site of an infection or infectious disease, a localized site of an injury or other damage, a transplant or other surgical site, or a blood clot. Further, microparticles produced by encapsulating hundreds of liposomal nanoparticles, and their therapeutic uses, are also described.

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LIPIDS FOR DELIVERY OF CHARGED MATERIAL, FORMULATIONS THEREOF AND METHOD FOR MAKING SAME

NºPublicación: US2022304929A1 29/09/2022

Solicitante:

INTEGRATED NANOTHERAPEUTICS INC [CA]
UNIV BRITISH COLUMBIA [CA]

CN_114945555_PA

Resumen de: US2022304929A1

Disclosed herein is a lipid having a net charge at physiological pH, and being covalently attached to a lipid moiety. The lipid moiety comprises a hydrocarbon structure having two or more linked hydrocarbon chains, optionally having cis or trans C═C, at least one of said chains being covalently attached to the head group optionally via the linker region. The hydrocarbon chains are bonded to one another at a branch point at an internal carbon of the chain attached to the linker region, which branch point comprises a functional group having an electronegative atom. The hydrocarbon chains each have between 1 and 40 carbon atoms, wherein the hydrocarbon structure in total comprises between 10 and 150 carbon atoms. Advantageously, the hydrocarbon structure may assume a generally flared shape for enhanced delivery of cargo molecules. Further provided are delivery vehicles comprising the lipids.

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SUPPOSITORIES COMPRISING CANNABINOIDS

NºPublicación: US2022304925A1 29/09/2022

Solicitante:

APIRX PHARMACEUTICAL USA LLC [US]

Resumen de: US2022304925A1

This invention relates to a suppository composition comprising cannabinoids. The suppository composition is formulated for easy absorption through mucosal membrane. The suppository as provided herein is useful for administration of cannabinoids in patients with nausea, vomiting, other conditions preventing swallowing, or conditions wherein suppository administration is required. Methods to manufacture the suppository composition are provided. Methods to treat pain, nausea, post-operative ileus and/or inflammatory bowel diseases using the suppository according to this invention are also provided.

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Mitochondrial Performance Enhancement Nanoemulsion Method

NºPublicación: US2022304927A1 29/09/2022

Solicitante:

QUICKSILVER SCIENT INC [US]

US_11344497_B1

Resumen de: US2022304927A1

An aqueous, intra-oral, nanoemulsion blend is provided that enhances mitochondrial performance in mammals when orally administered. The blend includes at least two different monolayer surfactant bound particle components and at least one bilayer water-core liposome component. The blend optionally may include a micelle.

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CHITOSAN POROUS STRUCTURE-BASED MAGNETICALLY ACTUATED MICROROBOT

NºPublicación: US2022305243A1 29/09/2022

Solicitante:

BIOT KOREA INC [KR]
KOREA INST OF MEDICAL MICROROBOTICS [KR]

KR_20220055223_PA

Resumen de: US2022305243A1

The present invention relates to a porous structure-based magnetically actuated microrobot and a fabricating method therefor, wherein the porous structure-based magnetically actuated microrobot is based on a natural polymer having biocompatibility and biodegradability, so that the precise targeting of the porous microrobot through the attachment of magnetic nanoparticles and the drug and cell delivery using the porous microrobot can be attained.

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IMMUNE MICROBUBBLE COMPLEX, AND USE THEREOF

NºPublicación: US2022305139A1 29/09/2022

Solicitante:

IMGT CO LTD [KR]

CN_114340682_PA

Resumen de: US2022305139A1

Provided is an immune microbubble complex, and a use thereof. An immune-microbubble complex (IMC) according to the presently claimed subject matter includes microbubbles to which an antibody is conjugated, in which the microbubbles have excellent stability and excellent antibody binding strength, and it was confirmed that, when the immune-microbubble complex is treated with high-intensity focused ultrasound (HIFU), an anti-tumor effect is significantly increased and an immune-enhancing effect is exhibited. Therefore, the immune-microbubble complex according to the presently claimed subject matter is expected to increase the efficiency of delivering the conjugated antibody and be used in both diagnosis and treatment of cancer, and exhibit various functions in the field of immunotherapy, including a contrast effect, half-life improvement, improved drug delivery, a lymphocyte concentration effect, cancer immunotherapy and induction of immunotherapy using ultrasound.

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COMPOSITIONS AND ARTICLES COMPRISING (NANO)DIAMOND PARTICLES

NºPublicación: US2022305140A1 29/09/2022

Solicitante:

DEBINA DIAGNOSTICS INC [US]

JP_2022536972_PA

Resumen de: US2022305140A1

Compositions and articles comprising diamond particles, such as nanodiamond based pharmaceutical compositions, are generally provided. In some embodiments, the articles and methods comprising (nano)diamond particles may be useful for monitoring and/or treating a disease (e.g., in a subject).

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Process for converting inhomogeneous aqueous solutions containing incompatible inorganic and organic components intr a homogeneous solution

NºPublicación: HU2100129A2 28/09/2022

Solicitante:

INNOSTUDIO [HU]

Compositions and methods for delivery of RNA

NºPublicación: GB2605312A 28/09/2022

Solicitante:

HDT BIO CORP [US]

US_2022249691_A1

Resumen de: GB2605312A

The disclosure provides nanoemulsion compositions and methods of making and using thereof to deliver a bioactive agent such as a nucleic acid to a subject. The nanoemulsion composition comprises a hydrophobic core based on inorganic nanoparticles in a lipid nanoparticle that allows imaging as well as delivering nucleic acids. Methods of using these particles for treatment and vaccination are also provided.

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DEVICE FOR THE PREPARATION OF FUNCTIONALISED SUBSTANCES

NºPublicación: EP4061381A1 28/09/2022

Solicitante:

GRADE MEDICAL S R O [CZ]

CZ_2019720_A3

Resumen de: WO2021098892A1

A device for the preparation of functionalised substrates, in particular the device for the preparation of functionalised substrates (7) for medical and/or cosmetic use, comprising a modification chamber (1) for applying a modification solution containing nanoparticles and/or micro-particles containing encapsulated active substance onto a carrier substrate (6) by means of a pressure drop between the inlet part (16) and the outlet part (17) of the modification chamber (1), the modification chamber (1) being connected to a module (3) for preparing a modification solution containing at least one active substance.

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CTGF GENE-SPECIFIC DOUBLE-STRANDED OLIGONUCLEOTIDE, AND A COMPOSITION FOR PREVENTING AND TREATING FIBROTIC DISEASES AND RESPIRATORY-RELATED DISEASES COMPRISING SAME

NºPublicación: EP4063504A1 28/09/2022

Solicitante:

BIONEER CORP [KR]

CN_114981433_PA

Resumen de: EP4063504A1

The present invention relates to a double-stranded oligonucleotide capable of inhibiting CTGF expression with a very specific and high efficiency, a double-stranded oligonucleotide structure and nanoparticles comprising the double-stranded oligonucleotide, and a use thereof in preventing or treating of fibrotic or respiratory diseases.

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IONIZABLE LIPIDS AND NANOPARTICLE COMPOSITIONS THEREOF

NºPublicación: EP4061797A1 28/09/2022

Solicitante:

GENERATION BIO CO [US]

BR_112022007481_A2

Resumen de: WO2021102411A1

Provided herein are ionizable lipids represented by the Formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R1, R2, R3, R4, R5,R6, m, and n are as defined herein. Also provided herein are lipid nanoparticle (LNP) compositions comprising an ionizable lipid of the invention and a capsid-free, non-viral vector (e.g., ceDNA). These LNPs can be used to deliver a capsid-free, non-viral DNA vector to a target site of interest (e.g., cell, tissue, organ, and the like).

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KIT FOR PREPARING NANOPARTICLE COMPOSITION FOR DRUG DELIVERY

NºPublicación: EP4062908A1 28/09/2022

Solicitante:

SAMYANG HOLDINGS CORP [KR]

CN_114980870_PA

Resumen de: EP4062908A1

The present invention relates to a kit for preparing a nanoparticle composition for drug delivery and, more specifically, to a kit for preparing a nanoparticle composition for drug delivery, wherein the kit is designed such that the kit does not comprise a polylactic acid salt and nanoparticles containing a drug encapsulated therein can be easily formed just by simply mixing an amphiphilic block copolymer, a cationic compound, and a drug as components of the kit.

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一种纳米疫苗及应用

NºPublicación: CN115105485A 27/09/2022

Solicitante:

南通大学南通市老年康复医院南通市肿瘤医院

Resumen de: CN115105485A

本发明公开了一种纳米疫苗,通过以下方法制备:S1、纳米化达沙替尼的制备;S2、PLT制备,将新鲜血液分离得到血小板,经脂质体挤出器处理,获得血小板膜液;S3、超声包载,取S1中制备的纳米化达沙替尼溶液与血小板膜液,充分超声混匀后,进行超声包载;S4、离心收集,将S3中超声包载后的溶液离心,即得所述纳米疫苗。本发明通过对达沙替尼进行纳米化修饰,有利于血小板的包载,提高达沙替尼的治疗效果。

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一种乳酸菌和白藜芦醇的联合制剂及其制备方法和应用

NºPublicación: CN115105487A 27/09/2022

Solicitante:

绍兴同创生物科技有限公司

Resumen de: CN115105487A

本发明涉及微生物制剂技术领域,具体而言,涉及一种乳酸菌和白藜芦醇的联合制剂及其制备方法和应用。该联合制剂内载入白藜芦醇的纳米颗粒和乳酸菌,可提高白藜芦醇的溶解性和稳定性,并将益生菌共同载入微囊中,还可以提高活菌在上消化道中的存活率,并实现白藜芦醇与活菌同时靶向递送至肠道菌群,提高两种药物的联合活性,发挥调节肠道菌群的作用,对治疗结肠炎具有一定的效果。

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一种双阴离子多糖稳定化的大豆分离蛋白-姜黄素自组装纳米粒子及其制备方法

NºPublicación: CN115105486A 27/09/2022

Solicitante:

自然资源部第三海洋研究所

Resumen de: CN115105486A

本发明提供了一种双阴离子多糖稳定化的大豆分离蛋白‑姜黄素自组装纳米粒子及其制备方法,包括:将姜黄素乙醇溶液加入到大豆分离蛋白溶液中,均质,得到混合溶液;将卡拉胶溶液加入到混合溶液中,调节溶液pH至2.5~4.5,均质,使大豆分离蛋白与卡拉胶复合凝聚反应完全,形成卡拉胶‑大豆分离蛋白纳米颗粒分散液;将岩藻多糖溶液加入到卡拉胶‑大豆分离蛋白纳米颗粒分散液中,均质,去除体系中残留的乙醇,冷冻干燥,即得。本发明采用卡拉胶与岩藻多糖双重阴离子多糖作为复合涂层,有效提高了载姜黄素的大豆分离蛋白纳米颗粒的水再分散性与稳定性,且在提高姜黄素稳定性的同时还可以与姜黄素协同增强其生物活性。

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一种藤黄酸纳米制剂及其制备方法

NºPublicación: CN115093434A 23/09/2022

Solicitante:

中国中医科学院中药研究所

Resumen de: CN115093434A

本发明提供了一种藤黄酸纳米制剂及其制备方法,属于制药领域。本发明构建了一种肝癌细胞靶向的还原敏感载体GA‑PEG2k‑SS‑PCL5k用于藤黄酸二聚体前药的有效递送,使藤黄酸二聚体前药结构更容易被药物载体通过疏水相互作用包裹进入内核。该药物载体GA‑PEG2k‑SS‑PCL5k与藤黄酸二聚体能够形成稳定的GA‑PEG2k‑SS‑PCL5k/藤黄酸二聚体纳米制剂,该纳米制剂的包封率高达95.97%,载药量高达30.45%,应用前景广阔。

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一种细胞膜包被的前药纳米粒、制备方法及应用

NºPublicación: CN115089561A 23/09/2022

Solicitante:

浙江大学医学院附属第一医院

Resumen de: CN115089561A

本发明公开了一种细胞膜包被的前药纳米粒,包括:由脂质单分子层和装载于所述脂质单分子层中的SN38前药组成的SN38前药脂质纳米粒以及包裹在纳米粒外面的细胞膜;所述的脂质单分子层由卵磷脂、胆固醇和DDAB/DOTAP作为骨架,同时以DSPE‑PEG2k双亲性聚合物作为添加剂。本发明同时提供了一种上述细胞膜包被的前药纳米粒的制备方法及应用。本发明的这种仿生纳米载药平台表现出活性药物的酯酶响应性释放,显著延长了药物的体内循环时间,提高了药物的生物利用度,增强了药物的抗肿瘤生长的效果。本发明提供的仿生纳米载药平台为小分子化疗药物提供了广阔的临床转化前景,也为肿瘤治疗提供的新的选择方案。

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一种烷基葡糖酰胺与IR780复合的选择性光热杀菌纳米材料及其制备方法和应用

NºPublicación: CN115089706A 23/09/2022

Solicitante:

华南农业大学

Resumen de: CN115089706A

本发明公开了一种烷基葡糖酰胺与IR780复合的选择性光热杀菌纳米材料及其制备方法和应用。所述选择性光热杀菌纳米材料由烷基葡糖酰胺、荧光染料IR780和助表面活性剂作为原料制备获得,所述选择性光热杀菌纳米材料为核壳结构,外壳为烷基葡糖酰胺,内核为荧光染料IR780。所述选择性光热杀菌纳米材料载药率高,稳定性好,且粒径小,粒径均匀性好;其包封率可达95%,载药率可接近4.5%,且制备成功后24小时内无IR780的析出,光吸收谱稳定。此外,该纳米材料具有选择性杀灭作用,杀菌效率高,可在5min内升温达20摄氏度,实现快速杀菌作用,且毒性小,具有较好的生物安全性。

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PROVISION OF BACTERIOPHAGES IN VARIOUS DOSAGE FORMS AND BACTERIOPHAGE APPLICATION DEVICE

NºPublicación: CN115103665A 23/09/2022

Solicitante:

Pha\u79D1\u6280\u6709\u9650\u516C\u53F8

DE_102020100725_A1

Resumen de: WO2021143962A1

The invention relates to the provision of bacteriophages in various dosage forms, namely in intracorporeal form, naso-pharyngeal and pulmonary form, cutaneous form and in the form of bacteriophage suture material and also in the form of a two-syringe bacteriophage preparation, to a dispenser for providing bacteriophages in a naso-pharyngeal and pulmonary dosage form and to a bacteriophage-sensitive tester application.

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一种基于微流控芯片的载药聚多巴胺铁纳米颗粒的制备方法及其应用

NºPublicación: CN115089560A 23/09/2022

Solicitante:

东华大学

Resumen de: CN115089560A

本发明涉及一种基于微流控芯片的载药聚多巴胺铁纳米颗粒的制备方法及其应用,所述纳米颗粒以含二价铁离子、多巴胺、药物、蛋白的原料,通过微流控芯片获得。本发明以微流控芯片为反应器制备的纤连蛋白包覆的载药聚多巴胺铁纳米颗粒,生物安全性好,可特异性靶向肿瘤区域,选择性递送药物,实现T1磁共振成像,同时实现肿瘤的增强化学动力治疗/化疗/免疫治疗三模态联合治疗,在癌症诊疗方面具有潜在的应用前景。

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METHODS OF CANCER TREATMENT BY DELIVERY OF SIRNAS AGAINST BCLXL AND MCL1 USING A POLYPEPTIDE NANOPARTICLE.

NºPublicación: WO2022197607A2 22/09/2022

Solicitante:

SIRNAOMICS INC [US]

US_2022288228_PA

Resumen de: WO2022197607A2

Compositions and methods are provided for the silencing of the BCLxL and MCL1 genes. Specifically, siRNA compositions are provided that contain siRNA molecules that target the BCLxL and MCL1 genes. Methods for using these compositions for treating cancer also are provided.

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Neuropilin-1 Specific Binding Peptide, Fusion Protein Fused with Same, and Use Thereof

Nº publicación: US2022298220A1 22/09/2022

Solicitante:

PINETREE THERAPEUTICS INC [US]

ES_2894299_T3

Resumen de: US2022298220A1

A peptide that binds specifically to neuropilin-1 (NRP1) without binding to neuropilin-2 (NRP2) is provided. A fusion protein, a fusion antibody, small-molecule drug, a nanoparticle, or a liposome, which comprises the peptide, and a pharmaceutical composition for treating or preventing cancer or angiogenesis-related diseases, and a composition for diagnosing cancer or angiogenesis-related diseases are provided. A polynucleotide encoding the peptide that binds specifically to NRP1 and a method for screening the peptide that binds specifically to NRP1 are provided. An antibody heavy-chain constant region Fc-fused peptide binding specifically to NRP1 has the property of binding specifically to NRP1, and thus when it is administered in vivo, it accumulates selectively in tumor tissue, and widens the intercellular space between tumor-associated endothelial cells to promote its extravasation and increases its tumor tissue penetration.

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