Resumen de: US2021145613A1

A prosthetic device includes a polymer lattice structure. The lattice structure includes a first surface arranged to face toward a residual limb, a second surface arranged to face away from the residual limb, a thickness between the first and second surfaces, and a variable lattice density across the thickness.

Resumen de: GB2605150A

A ceramic acetabular cup 10 comprises an inner wall 12 having a part-spherical articulating surface for non- captively receiving a femoral head. In one embodiment the cup has an outer wall 14 having an outer surface 22 for enabling bone fixation and cavity 26 is located between an interior surface 20 of the inner wall and an interior surface 24 of the outer wall. The cup may be optionally formed from a ceramic material in an additive manufacturing process. In a further embodiment the cup has at least one bone engaging component and is at least part formed via an additive manufacturing process.

Resumen de: WO2021099091A1

The invention relates to a method for producing an implant from a biocompatible silicone, comprising the following steps: A mathematical 3D model is provided of an implant to be produced; a 3D model of a casting mould for the implant is created as a negative, using the 3D model of the implant; the casting mould is produced from a polymeric material by an additive manufacturing process; the casting mould is coated, at least in the regions that come into contact with the silicone to be cast; the coating process is achieved by gas-phase deposition of a coating material from the parylene family; the biocompatible silicone is introduced into the mould cavity of the coated casting mould; the casting mould is heated so that the silicone vulcanises and the vulcanised implant, once cooled, is released from the casting mould.

Resumen de: WO2021101801A1

Provided herein is a method of making a flexible partial denture, which may include: (a) producing a partial denture base by additive manufacturing (e.g., bottom-up or top-down stereolithography) from a dual cure resin, with the dual cure resin comprising a light polymerizable component and a heat polymerizable component, with the denture base including at least one tooth socket; (b) inserting an acrylic artificial tooth into each at least one tooth socket to produce an assembled intermediate product; and then (c) baking said assembled intermediate product for a time sufficient to cure said heat polymerizable component in said denture base and retained dual cure resin, bond said tooth into each at least one socket with said retained dual cure resin, and produce said flexible partial denture. A flexible partial denture produced and resin formulations useful for the same are also provided.

Resumen de: EP4063042A1

Die vorliegende Erfindung betrifft ein Verbundmaterial aus einem Matrixwerkstoff und Silber, wobei das Silber homogen in dem Matrixwerkstoff verteilt ist und der Gehalt an Silber im Verbundmaterial zwischen 5 Gew.-% und 40 Gew.-% liegt sowie Verfahren zur Herstellung dieses Verbundmaterials und medizinische Implantate enthaltend dieses Verbundmaterial. Das Verbundmaterial ist insbesondere zur Reduktion und Vermeidung von Biofilmbildung geeignet.

Resumen de: CN115105166A

本发明一种超声刀刀头弯头及制作方法和打印装置，制作方法，包括如下步骤，步骤1：确认需要打印的超声刀刀头模型，并对刀头进行空间划分，划分超声刀刀头的直杆和弯头；步骤2：在空间上将弯头分割形成若干段，对每段进行打印，并根据每段的打印进度，阶段性调整三维打印设备的成型平台斜率，完成弯头的打印。通过上述方法制得超声刀刀头弯头。一种三维打印装置，它包括金属3D打印设备以及控制设备内成型平台摆动的多向摆动机构，多向摆动机构带动平台实现竖直向、水平向以及倾斜的运动。本发明的优点为：1提供一种生产制造更方便、能够自定义定制，且生产成本的弯头制造方法。2：弯头的方向性指向和应力分布有利于超声振动的传递。

Resumen de: CN115105630A

本发明公开了一种内嵌有壳聚糖/明胶复合水凝胶的3D打印材料及其制备方法，涉及3D打印材料技术领域。本发明先制备羟基磷灰石/聚乳酸复合材料，然后再制备羟基磷灰石/聚乳酸复合3D打印支架以及壳聚糖/明胶复合水凝胶，最后将制备的羟基磷灰石/聚乳酸复合3D打印支架浸泡在壳聚糖/明胶复合水凝胶中，经抽真空以及冷冻干燥后制成一种内嵌有壳聚糖/明胶复合水凝胶的3D打印材料。本发明所制备的内嵌有壳聚糖/明胶复合水凝胶的3D打印材料兼具聚乳酸的可降解性、羟基磷灰石的生物活性和成骨能力、水凝胶的吸水性和软组织相容性的优点。

Resumen de: CN115089262A

本发明提出一种基于3D打印的髋关节截骨导航系统,包括应用层、数据层、反馈层和网络传输层，所述应用层的输出端与数据层的输入端连接，且应用层包括髋关节固定模块、图像采集模块、关节CT扫描模块、总计算机以及3D打印接入模块，所述数据层的输出端与反馈层的输入端连接，且数据层包括原始数据存储模块和图像数据存储模块，所述反馈层包括移动终端和固定终端，本发明通过引用图像采集以及薄层CT扫描两种方式来获取患者的髋关节数据，并根据获取的数据建立对于的3D髋关节模型，使得二种方式建立的模型可以相互验证，来提升模型导航数据的精准性，以便后续医生借助3D打印出来的模型进行手术预演。

Resumen de: CN115090883A

本发明属于医用植入体制造技术领域，具体公开了一种医用多孔钛铁合金植入体及其制备方法。本发明先将铁粉、钛粉和银粉混合得到混合粉体备用，然后将植入组织的三维模型进行切片处理，导入3D打印机；铺设混合粉体，采用激光烧结进行逐层打印，得到植入体半成品；最后将植入体半成品与电池正极连接进行微弧氧化，得到医用多孔钛铁合金植入体。本发明制备的医用多孔钛铁合金植入体降低了植入体的弹性模量，与人骨更加匹配，同时还能促进细胞和微血管的生长，更快的形成骨结合。

Resumen de: FR3120783A1

Procédé de fabrication d’un assemblage de pose d’un appareil orthodontique et assemblage de pose associé L’invention se rapporte à un procédé de fabrication d’un assemblage (10) de pose d’un appareil orthodontique, ledit assemblage de pose comprenant l’appareil orthodontique (12) et un élément de pose (14) assemblés l’un à l’autre. Le procédé comprend les étapes suivantes : - réalisation d’une image numérisée d’une rangée de dents (18) d’un patient ; - fabrication d’un support de pose par fabrication additive à partir de l’image numérisée, le support de pose correspondant aux dents de la rangée ; - fabrication de l’appareil orthodontique et fixation dudit appareil sur le support de pose ; puis - fabrication de l’élément de pose (14) en recouvrant l’appareil orthodontique et le support de pose, assemblés l’un à l’autre, d’un matériau (60) fluide élastomère ; puis - dissociation de l’appareil orthodontique et du support de pose. Figure pour l'abrégé : Figure 1

Resumen de: CN115090903A

本发明公开了一种基于分子筛功能基元的医疗植入件及其制备方法与应用。首先对分子筛结构进行单元选取，并对单元模型进行重构生成分子筛功能基元，包括但不限于孔径、杆径、孔隙率、单元尺寸等孔隙参数的定义，还可将分子筛多孔结构设计成杆径平滑变化的梯度多孔结构，经孔隙参数优化后输出多孔植入件假体模型并利用增材制造方法成形制备。本发明开创性地使用分子筛结构作为多孔医用植入件的单元结构，优化分子筛结构的孔隙率、孔径等参数，使设计的分子筛功能基元满足组织细胞黏附、增殖、分化等不同生物行为的同时，也满足增材制造技术工艺限制。本发明制备得到的基于分子筛功能基元的医疗植入件在人工假体中具有广泛的应用前景。

Resumen de: CN115089173A

本发明的目的在于提供基于显色反应的组织液提取检测方法和一体化的微针贴片，以解决目前小尺寸微针难以精确制备以及缺少葡萄糖快速定量检测的装置和方法的问题，一体化微针贴片，包括：微针显色底座、水凝胶微针阵列，所述的微针显色底座与所述的水凝胶微针阵列固定连接，所述的微针显色底座包括：阳离子化的甲基酰化明胶纳米纤维膜、3,3',5,5'‑四甲基联苯胺，所述的水凝胶微针阵列中包括：葡萄糖氧化酶；所述的阳离子化的甲基酰化明胶纳米纤维膜的纤维直径在100nm‑1000nm之间。

Resumen de: CN115089328A

本发明提供了一种表面梯度微孔结构的牙种植体系统及其制备方法，其中所述牙种植体系统包括无螺纹微锥柱形的牙种植体和基台，其中所述牙种植体包括具有仿生骨小梁结构的微孔层和具有极高致密性和机械强度的基体。本发明可实现牙种植体系统同时具备内部结构的精密性和表面结构的仿生特点，有效改善植入后的长期稳定性、降低牙种植体系统的加工工艺流程的复杂度并可实现个性化和批量化生产。

Resumen de: US2022297184A1

The inventive concept relates to method for manufacturing a metal based component comprising at least one protrusion. The method comprises: providing a metal based substrate comprising a surface having at least one cavity; providing a metal based protrusion element comprising a first portion and a second portion, wherein said first portion has a shape that conforms to a shape of the cavity; arranging the first portion of the protrusion element in said cavity such that at least the second portion of the protrusion element protrudes at least 5 mm from a surface of the metal based substrate, to form a substrate comprising a protrusion; placing said substrate comprising a protrusion in a canister such that a void is formed between the canister and the surface of the substrate comprising the protrusion; filling at least a portion of the void with a diamond powder such that the surface of the substrate comprising the protrusion is covered by the inert filler material; removing gas from the interface between said diamond powder and said substrate comprising

Resumen de: WO2022195521A1

The invention provides an oromucosal film composition comprising: a therapeutically effective amount of epinephrine solid particles having a particle size in the range of from about 0.01 um to about 100 um; and a pharmaceutically acceptable polymer wherein the epinephrine solid particles are dispersed in and/or disposed on a polymeric layer. The film compositions can be used for the treatment of anaphylactic shock, cardiac arrest, asthma, bronchial asthma, bronchitis, emphysema, respiratory infections, and allergic reactions. The film compositions may further contain local anesthetics and used for providing local anesthesia, such as for the treatment or prevention of tooth pain.

Resumen de: US2022296475A1

A feeding device includes a fluid reservoir and a nipple configured to be attached to the fluid reservoir. The nipple includes a body portion defining a compartment configured to contain a liquid so as to mimic a feel of a mother's breast. The body portion comprises a nipple tip comprising a fluid outlet. The nipple includes a base member attached to the body portion, the base member including an attachment portion configured to attach the nipple to the fluid reservoir. The base member comprises a fluid inlet in fluid communication with the fluid reservoir. The nipple includes a fluid passageway extending through the compartment from the fluid inlet to the nipple tip, where the fluid passageway allows fluid to flow from the fluid reservoir to the fluid outlet. A valve member positioned on the base member adjusts a flow rate of fluid from the fluid reservoir into the fluid passageway.

Resumen de: US2022296345A1

The present disclosure provides a photopolymerizable composition. The photopolymerizable composition includes at least one urethane component, at least one monofunctional reactive diluent, an initiator, and optionally an inhibitor. The present disclosure also provides an article including the reaction product of the photopolymerizable composition. Further, the present disclosure provides a method of making an article. The method includes (i) providing a photopolymerizable composition and (ii) selectively curing the photopolymerizable composition to form an article. The method optionally also includes (iii) curing unpolymerized urethane component and/or reactive diluent remaining after step (ii). Further, methods are provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an article; and generating, with the manufacturing device by an additive manufacturing process, the article based on the digital object. A system is also provided, including a display that displays a 3D model of an article; and one or more processors that, in response to the 3D model selected by a user, cause a 3D printer to create a physical object of an article.

Resumen de: US2022304150A1

A substrate for use in an electronic skin is disclosed herein. The substrate comprises a base polymer layer, and a first intermediate polymer layer attached to the base polymer layer by a first adhesive layer. The first intermediate polymer layer comprises a first intermediate polymer in which electron-rich groups are linked directly to one another or by optionally substituted C1-4 alkanediyl groups. A first conductive layer is attached to the first intermediate polymer layer by a second adhesive layer or by multiple second adhesive layers between which a second intermediate polymer layer or a second conductive layer is disposed.

Resumen de: WO2022197247A1

Disclosed herein is a hygromorphic composite material comprising a moisture-active pollen paper substrate formed from a plurality of pollen microgel particles, and at least one moisture-inactive layer applied onto the top and/or bottom surface of the moisture-active pollen paper substrate with a pattern that causes the hygromorphic composite material to change its shape in a pre-determined manner due to a change in relative humidity of its ambient environment. Also disclosed herein is a method of forming the hygromorphic composite material.

Resumen de: WO2022192966A1

The present invention relates to compositions suitable for the delivery of agents to biological targets such as tissues and cells and/or capable of promoting the growth and/or proliferation of cells, and methods for the production thereof. Specifically, a printable collagen bioink comprising type IV collagen is used to produce crosslinked collagen gels comprising mammalian cells, such as endothelial or epithelial cells, for corneal regeneration.

Resumen de: WO2022193904A1

The present disclosure provides a knee joint replacement intelligent navigation guide plate, comprising a main frame and fitting surface columns. Mounting holes are arranged on the main frame. The fitting surface columns are detachably mounted on the mounting holes, and are formed by 3D printing. According to the knee joint replacement intelligent navigation guide plate, the main frame can be prepared in a conventional manner, the fitting surface columns formed by 3D printing are assembled to the main frame, so that the structural strength of the knee joint replacement intelligent navigation guide plate can be greatly improved, and the surgical field of view can be exposed as much as possible. At the same time, it is also possible to reduce printing consumables and improve economy of the guide plate, and it is also guaranteed that the main frame can adapt to various sterilization modes, and the structure precision error is low.

Resumen de: WO2022198100A1

Custom radioactive seed carriers are fabricated pre-operatively and/or intraoperatively to more precisely match carrier specification of a radiation treatment plan for a particular patient. One or more carrier specification component, such as a 3D printer, injection molding system, machining component, or bioprinter, may be utilized to create the custom carrier.

Resumen de: WO2022197701A1

The current invention describes a method for developing bioactive borate glass (BBG)- hydrogel constructs based on 3D printing technology for healing of burn wounds and low-tomoderate exuding wounds. The hydrogels serve as a water reservoir and binder for BBG, to provide hydration of the BBG-hydrogel construct and to make the bioink printable, while 3D printing technology enables the layer-by-layer deposition of multiple materials including BBG and hydrogels such as alginate, gelatin, GelMa, cellulose, chitosan and other like materials, as well as control of pore geometry to increase the available surface area for wound-dressing contact and more favorable cell-biomaterial interactions.

Resumen de: WO2021000794A1

A 3D printing method for a complex curved hollow structure. The 3D printing method comprises: firstly manufacturing a bottom die (B) attached to a complex curved hollow structure, and forming the complex curved hollow structure on a forming surface (C) of the bottom die (B) by taking the bottom die (B) as a support. The forming of the bottom die (B) and the forming of the complex curved hollow structure are completed under the same world coordinate system without the need to remove the bottom die (B) from an object carrying table (2), and then transplanting the bottom die into a printing system of a member (A) to be formed. An advantage of the method lies in that a high-precision complex curved hollow structure can be manufactured.

Resumen de: AU2020437666A1

A medical implant which comprises a porous lattice is fabricated with additive manufacturing techniques such as direct metal laser sintering. A CAD model of the porous lattice is created by defining a trimming volume and merging some lattice elements with adjacent solid substrate.