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Resultados 68 resultados LastUpdate Última actualización 28/05/2020 [04:27:00] pdf PDF xls XLS

Solicitudes publicadas en los últimos 90 días / Applications published in the last 90 days



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NANOPORE-MATCHED PROTEIN SHUTTLE FOR MOLECULAR CHARACTERIZATION

NºPublicación: EP3655423A1 27/05/2020

Solicitante:

HARVARD COLLEGE [US]
UNIV MASSACHUSETTS [US]

CN_110914291_A

Resumen de: WO2019018398A1

Systems and methods are provided for trapping and electrically monitoring molecules in a nanopore sensor. The nanopore sensor comprises a support structure with a first and a second fluidic chamber, at least one nanopore fluidically connected to the two chambers, and a protein shuttle. The protein shuttle comprises an electrically charged protein molecule, such as Avidin. The nanopore can be a Clytosolin A. A method can comprise applying a voltage across the nanopores to draw protein shuttles towards the nanopores. The ionic current through each or all of the nanopores can be concurrently measured. Based on the measured ionic current, blockage events can be detected. Each blockage event indicates a capture of a protein shuttle by at least one nanopore. Each blockage event can be detected through a change of the total ionic current flow or a change in the ionic current flow for a particular nanopore.

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BACTERIOCINS FOR CONTROL OF SALMONELLA ENTERICA

NºPublicación: JP2020513822A 21/05/2020

Solicitante:

ノマド・バイオサイエンス・ゲーエムベーハー

US_2020010517_A1

Resumen de: EP3378485A1

The present invention relates to bacteriocins for control of Salmonella enterica (salmocins). The bacteriocins are derived from Salmonella. The salmocins can be expressed in plants and can be used in a method of preventing or reducing infection or contamination of an object with Salmonella.

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WHOLE CELL VACCINES

NºPublicación: JP2020513802A 21/05/2020

Solicitante:

ロンドンスクールオブハイジーンアンドトロピカルメディシンLONDONSCHOOLOFHYGIENE&TROPICALMEDICINE

US_2020009241_A1

Resumen de: WO2018167485A1

The disclosure relates to attenuated bacterial cells expressing glycans and glycoconjugate antigens and their use in the manufacture of whole cell vaccines effective at preventing or treating bacterial infections in non-human species.

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Nanomaterial-based Bacterial Sensors

NºPublicación: US2020158642A1 21/05/2020

Solicitante:

AGENCY SCIENCE TECH & RES [SG]

WO_2018182510_PA

Resumen de: US2020158642A1

This invention relates to a sensor that detects bacteria cells comprising (a) a primary negatively charged, nanoparticulate sensing material; (b) a secondary positively charged, fluorescent sensing material; (c) a housing; and (d) at least one illuminator; wherein said housing contains said primary negatively charged, nanoparticulate sensing material, said secondary positively charged fluorescent sensing material and a sample potentially comprising bacteria in aqueous medium, wherein said illuminator provides light of at least one pre-specified wavelength λi to excite at least said secondary positively charged, fluorescent material, wherein said secondary positively charged, fluorescent material electrostatically attached to bacteria cells provides at least one fluorescent response at a second different wavelength λn wherein both i and n are integers, wherein said negatively charged, nanoparticulate sensing material electrostatically attached to said fluorescent material suppresses fluorescing of said fluorescent material at said second wavelength λn; and wherein said housing permits illumination of the contents of said housing by said illuminator and wherein said housing further permits the detection of a fluorescent response at a second wavelength λn. The negatively charged material includes (dsDNA coated) spherical AuNPs and graphene oxide (GO). The positively charged fluorescent material includes water soluble cationic conjugated polyelectrolytes (COPE) or positively

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DENDROBIUM OFFICINALE ENDOPHYTIC FUNGUS STRAIN AND EXTRACELLULAR POLYSACCHARIDE PRODUCED THEREBY, AND EXTRACTION METHOD AND APPLICATION OF EXTRACELLULAR POLYSACCHARIDE

NºPublicación: US2020157590A1 21/05/2020

Solicitante:

UNIV SOUTH CHINA TECH [CN]

WO_2019000850_PA

Resumen de: US2020157590A1

The present invention provides a Dendrobium officinale (D. officinale) endophytic fungus strain and an extracellular polysaccharide produced thereby as well as an extraction method and application of the extracellular polysaccharide. The extraction process of the extracellular polysaccharide includes: activating a strain; culturing seed liquid; fermenting and culturing; filtering the fermented liquid under vacuum; concentrated the filtrate under vacuum; conducting alcohol precipitation on the concentrated liquid; precipitating and centrifuging; dialyzing after dissolving the precipitates in water; freezing and drying the dialysate under vacuum; and obtaining the extracellular polysaccharide. The D. officinale endophytic fungus strain belongs to Fusarium solani, and the extracellular polysaccharide produced thereby has inhibitory effects on Escherichia coli, Staphylococcus aureus, Salmonella ssp., and Bacillus subtilis.

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A method for specifically detecting living bacteria

NºPublicación: US2020158727A1 21/05/2020

Solicitante:

CENTRE NAT RECH SCIENT [FR]
UNIV PARIS SUD [FR]

ES_2556996_T3

Resumen de: EP2617833A1

The present invention concerns a method for detecting specifically living bacteria of a given category of bacteria in a sample comprising bacteria, the method comprising the steps of: a) incubating said bacteria of said sample with an analog of a monosaccharide compound, said monosaccharide being an endogenous monosaccharide residue of glycans of the outer membrane of such given category of bacteria, the said endogenous monosaccharide residue comprising an ulosonic acid or ulosonate salt residue, the said analog of a monosaccharide compound being a modified monosaccharide substituted at a given position by a first reactive chemical group capable to react with a second reactive group of a detectable molecule, and b) contacting said bacteria with a said detectable molecule comprising a said second reactive group, for generating the reaction of said first reactive group of said analog residue incorporated within said glycans of the outer membrane of said bacteria with said second reactive group of said detectable, and c) detecting whether said bacteria comprise said detectable molecule bound to the glycans of their outer membrane.

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SELF-ASSEMBLING PROTEIN SCAFFOLDS AND METHODS

NºPublicación: US2020157153A1 21/05/2020

Solicitante:

UNIV MINNESOTA [US]

WO_2019216930_A2

Resumen de: US2020157153A1

A protein scaffold includes a plurality of EutM subunits and a multi-enzyme cascade. The multi-enzyme cascade includes a first enzyme attached to the first EutM subunit and a second enzyme attached to the second EutM subunit. The scaffold may be formed by a method that generally includes incubating a plurality of EutM subunits under conditions allowing the EutM subunits to self-assemble into a protein scaffold, attaching a first enzyme of a multi-enzyme cascade to a first EutM subunit, and attaching a second enzyme of the multi-enzyme cascade to a second EutM subunit. The scaffold may be self-assembled in vivo or in vitro. Each enzyme may be, independently of any other enzyme, attached to its EutM subunit in vivo or in vitro. Each enzyme may be, independently of any other enzyme, attached to its EutM subunit before or after the scaffold is assembled.

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TUMOR ASSOCIATED VACCINES AND COMPOSITIONS FOR DISRUPTING TUMOR-DERIVED IMMUNOSUPPRESSION FOR USE IN COMBINATION CANCER IMMUNOTHERAPY

NºPublicación: US2020157549A1 21/05/2020

Solicitante:

HOPE CITY [US]

US_2019153452_A1

Resumen de: US2020157549A1

In one embodiment, a single modality cancer immunotherapy regimen that includes a therapeutic composition is provided. Such a therapeutic composition may include a Salmonella strain comprising a plasmid that expresses an shRNA molecule that suppresses the expression of an immunosuppressive target and suppresses tumor growth. In some aspects, the Salmonella strain is an attenuated Salmonella typhimurium strain. In other aspects, the immunosuppressive target is STAT3, IDO1, IDO2, Arginase 1, iNOS, CTLA-4, TGF-β, IL-10, pGE2 or VEGF. In one embodiment, the immunosuppressive target is IDO1 or Arg1 and the shRNA molecule is any one of SEQ ID NO:5-14.

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马流产沙门氏菌驴源株及其在制备驴副伤寒灭活疫苗中的应用

NºPublicación: CN111154678A 15/05/2020

Solicitante:

中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心)

Resumen de: CN111154678A

本发明公开了马流产沙门氏菌驴源株及其在制备驴副伤寒灭活疫苗中的应用,属于生物疫苗领域。本发明所述的马流产沙门氏菌驴源株,命名为20180422.D.DE.X,保藏在中国微生物菌种保藏管理委员会普通微生物中心,菌种保藏编号为:CGMCC No.18342。本发明的马流产沙门氏菌驴源株20180422.D.DE.X具有免疫原性好、培养特性好等优点,将该马流产沙门氏菌驴源株接种于沙门氏菌增菌液,培养后,用甲醛(终浓度0.2%)灭活后,制备成灭活疫苗。实验证明,使用本发明制备得到的灭活疫苗免疫小鼠,能够使小鼠免于强毒马流产沙门氏菌的攻击,且在驴体上免疫安全性良好。因此该疫苗具有安全、低剂量免疫等优点,是首个驴用马流产沙门氏菌灭活疫苗,可以用于预防由马流产沙门氏菌引起的驴副伤寒。

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DE-IMMUNIZED SHIGA TOXIN A SUBUNIT EFFECTOR POLYPEPTIDES FOR APPLICATIONS IN MAMMALS

NºPublicación: JP2020073569A 14/05/2020

Solicitante:

モレキュラーテンプレーツ,インク.MOLECULARTEMPLATES,INC.

ES_2749862_T3

Resumen de: WO2015113007A1

The present invention relates to Shiga toxin effector polypeptides with reduced antigenic and/or immunogenic potential. Immunogenicity can be a limitation for the repeated administration to mammals of proteins and polypeptides derived from Shiga toxins. The Shiga toxin effector polypeptides of the present invention have uses as components of therapeutics, diagnostics, and immunization materials. The cytotoxic proteins of the present invention have uses for selective killing of specific cell types and as therapeutics for the treatment of a variety of diseases, including cancers, immune disorders, and microbial infections. The proteins of the present invention also have uses for detecting specific cell types, collecting diagnostic information, and monitoring the treatment of a variety of diseases, such as, e.g., cancers, immune disorders, and microbial infections.

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LIVE SELF-DESTRUCTING BACTERIAL ADJUVANTS TO ENHANCE INDUCTION OF IMMUNITY

NºPublicación: WO2020096994A1 14/05/2020

Solicitante:

UNIV FLORIDA [US]

Resumen de: WO2020096994A1

Disclosed herein are unique adjuvant compositions comprising an attenuated derivative of a bacterial pathogen that undergoes lysis in vivo. In exemplary embodiments, the bacterial pathogen is a Salmonella spp. Also disclosed are methods for enhancing an immune response using the adjuvants disclosed herein.

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MULTIVALENT GLYCOCONJUGATES IMMUNOGENIC COMPOSITIONS

NºPublicación: WO2020095324A1 14/05/2020

Solicitante:

BHARAT BIOTECH INTERNATIONAL LTD [IN]

Resumen de: WO2020095324A1

Disclosed are multivalent conjugate compositions against Salmonella diseases. A combined vaccine composition of glycol-conjugates in tetravalent, trivalent and bivalent combinations are disclosed in the present invention.

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USE OF AMMONIA FOR DISINFECTION, APPLICATION METHOD AND DEVICE

NºPublicación: WO2020093118A1 14/05/2020

Solicitante:

WR IND E COMERCIO DE ELETRONICOS EIRELI ME [BR]

Resumen de: WO2020093118A1

Use of ammonia for disinfection of aviary bedding, and the method and application device therefor. The main advantage of the use of ammonia in this disinfection method is that it renders viable the rapid elimination of microorganisms present in the environment, especially Salmonella, allowing the resumption of production within substantially shorter periods of time in comparison to current agricultural practice.

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Control of Pathogenic Bacteria in Foods

NºPublicación: US2020146315A1 14/05/2020

Solicitante:

NEVADA NATURALS INC [US]

Resumen de: US2020146315A1

Methods of making coated pet food kibble and the kibble product by coating kibble with a composition that include at least one of: (i) lecithin and chicken fat; (ii) lecithin, a glycerol monoester of a fatty acid, a sugar monoester of a fatty acid, and chicken fat; (iii) lecithin, Nα-(C8-C18) acyl arginine alkyl (C8-C18) ester, and chicken fat; or (iv) Nα-(C8-C18) acyl arginine alkyl (C8-C18) ester-thymol and chicken fat. When the pet food kibble coated with a composition as described above, exhibits amounts of Salmonella sp. that are reduced by about 99%. This reduction is effective for at least 60 days post coating when compared to pet food kibble coated with a composition lacking one of (i)-(iv). The compositions are also used in a method for treating raw beef or poultry prior to grinding where the ground meat exhibits amounts of Salmonella sp. that are reduced by about 99%.

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Polysaccharide Purification for Vaccine Production using Lytic Enzymes, Tangential Flow Filtration, and Multimode Chromatography

NºPublicación: EP3649247A1 13/05/2020

Solicitante:

INVENTPRISE LLC [US]

KR_20200024896_A

Resumen de: US2019010187A1

An improved, cost effective and shortened process of purification of the capsular polysaccharide of S. Pneumoniae, Group B Streptococcus, H. Influenzae, S. Typhoid and N. meningitidis is disclosed. The process includes a cocktail of enzyme treatment, tangential flow filtration, and multimodal chromatography purification. For Gram-negative bacteria, endotoxin removal process involves endotrap HD resin. This shortened process achieved the purity required by WHO/EP/BP for the use in human vaccine preparation, with simple steps and higher yield as compared to conventional processes. The steps of the process avoid use of organic solvents such as, for example, alcohol, phenol, and ultracentrifugation that are otherwise expensive and time consuming to perform, and/or health hazards for commercial use. This process disclosed is also simple, efficient, non-toxic, easy to scale-up, and environmentally friendly.

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METHODS FOR GENERATING EPITOPES FOR BINDING TO RECOGNITION MOLECULES BY TEMPLATED ASSEMBLY

NºPublicación: CN111133104A 08/05/2020

Solicitante:

特里比奥迪卡有限责任公司

CA_3072569_A1

Resumen de: WO2019032942A1

The present disclosure provides polypeptides and polypeptide-nucleic acid conjugates comprising portions of epitopes, and methods of using target molecule binding components, such as aptamers, to present template sequences, where the target molecule binding components bind to target molecules unique to specific cellular targets, for the purpose of templated assembly of the epitopes for recognition molecules.

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METHOD FOR DETERMINING ESCHERICHIA COLI

NºPublicación: WO2020089512A1 07/05/2020

Solicitante:

AQSENS HEALTH OY [FI]

Resumen de: WO2020089512A1

The present invention is related to determining Escherichia coli from a sample such as urine. According to the method, part of sample is admixed with a reagent comprising a lanthanide(III) ion, a transition metal ion, and a transition metal ion/E. coli -specific M13 phage, and another part of the sample is admixed with the reagent comprising lanthanide(III) ion, the transition metal ion a wild-type M13 phage. The signals derived from the lanthanide(III) ions in the admixtures were detected with time-gated luminescence measurement. The presence of E. coli in the sample was determined by comparing the lanthanide(III) ion signal in the presence transition metal ion/E. coli -specific M13 phage and the wild type M13 phage.

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马流产沙门氏菌马源株及其在制备马流产沙门氏菌灭活疫苗中的应用

NºPublicación: CN111100817A 05/05/2020

Solicitante:

中国农业科学院哈尔滨兽医研究所(中国动物卫生与流行病学中心哈尔滨分中心)

Resumen de: CN111100817A

本发明公开了马流产沙门氏菌马源株及其在制备马流产沙门氏菌灭活疫苗中的应用,属于生物疫苗技术领域。本发明所述的马流产沙门氏菌马源株,命名为20180316.H.AES.G,保藏在中国微生物菌种保藏管理委员会普通微生物中心,其菌种保藏编号为:CGMCC No.18341。本发明的马流产沙门氏菌马源株20180316.H.AES.G具有免疫原性好、培养特性好等优点,将本发明的马流产沙门氏菌马源株接种于沙门氏菌增菌液,培养后,用0.2%v/v甲醛灭活,制成灭活疫苗。实验证明,使用本发明制备得到的马流产沙门氏菌灭活疫苗免疫小鼠,攻毒后,能使小鼠免于死亡,免疫马体后,安全性良好。因此该疫苗具有安全、低剂量免疫等优点。本发明首次提出了一种马流产沙门氏菌灭活疫苗,可以用于预防由马流产沙门氏菌引起的流产。

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BIRD FEED AND IN PARTICULAR POULTRY FEED, COMPRISING SYNTHETIC CAPSAICINOID DERIVATIVES AND SUCH FEED FOR PROHYLACTIC USE OR TREATMENT OF SALMONELLA INFECTION

NºPublicación: KR20200045569A 04/05/2020

Solicitante:

악시켐아베

CN_110839775_A

Resumen de: WO2017061871A1

The invention relates to bird feed comprising synthetic capsaicinoids for prohylactic use or treatment of salmonella infection.

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AMES NEGATIVE SUBLIMATION TONER

NºPublicación: US2020133153A1 30/04/2020

Solicitante:

ESPRIX TECH LP [US]

Resumen de: US2020133153A1

Provided are toners and combinations of toners that demonstrate excellent color and are Ames test negative in both Salmonellatyphimurium strains TA98 and TAIOO.

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APPARATUS AND METHOD FOR DETECTING MICROBIAL CONTAMINATION

NºPublicación: US2020132687A1 30/04/2020

Solicitante:

S D SYSTEMS INC [US]

CA_3060696_A1

Resumen de: US2020132687A1

Provided are novel methods for screening and testing for pathogens in food, water, and bodily fluids using methods that are faster to complete than conventional methods of culturing and plating that require lengthy times in properly equipped labs. The invention utilizes specific, rapid and sensitive optical detection to capture small concentrations of the target bacteria and render them amenable for detection with various specific synthesis binding agents approaches. The technique merges capture and detection steps with quantification unit suitable to provide results in a relatively shorter time current detection methods.

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GLYCOCONJUGATE VACCINES COMPRISING BASIC UNITS OF A MOLECULAR CONSTRUCT EXPRESSING BUILT-IN MULTIPLE EPITOPES FOR THE FORMULATION OF A BROAD-SPECTRUM VACCINE AGAINST INFECTIONS DUE TO ENTEROPATHOGENIC BACTERIA

NºPublicación: US2020129606A1 30/04/2020

Solicitante:

BIOSYNTH SRL [IT]

Resumen de: US2020129606A1

The present invention refers to new glycoconjugate antigens expressing built-in multiple epitopes and to polyvalent glycoconjugate vaccines intended for the protection of mammalians, and particularly for the protection of the human population from enteropathogenic bacteria, such as the Gram-positive anaerobic bacterium Clostridium difficile and the Gram-negative bacteria Salmonella typhi, Escherichia Coli, Vibrio Cholerae, Shigella flexneri, Salmonella typhimurium, Salmonella enteritidis, Salmonella paratyphi A, Shigella sonnei, Shigella dysenteriae, Salmonella cholerasuis, Klebsiella, Enterobacter, Pseudomonas aeruginosa and/or from viral gastrointestinal infections due to human noroviruses.

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GUT BACTERIA DERIVED MICROVESICLES FOR VACCINE DELIVERY

NºPublicación: WO2020084295A2 30/04/2020

Solicitante:

QUADRAM INST BIOSCIENCE [GB]

Resumen de: WO2020084295A2

The present invention relates to a vaccine suitable for immunisation against influenza, plague or Y. pestis infection said vaccine comprising outer membrane vesicles (OMVs) and the plague vaccine including the V and/or F1 antigens of Y. pestis.

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INFORMATION PROVIDING METHOD FOR DIAGNOSING PARKINSONS DISEASE

NºPublicación: US2020128801A1 30/04/2020

Solicitante:

UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV [KR]

WO_2018106020_PA

Resumen de: US2020128801A1

Provided is an information providing method for diagnosing Parkinson's disease by measuring the amount of any one target selected from the group consisting of a Proteus mirabilis strain, a metabolite produced by the Proteus mirabilis strain, and α-synuclein in a biological sample of a subject; a composition comprising a Proteus mirabilis strain as an active ingredient for fabricating a Parkinson's disease animal model; a method for fabricating a Parkinson's disease animal model, the method comprising a step for administering a Proteus mirabilis strain to an animal excluding human; and a method for screening a Parkinson's disease medicine, the method comprising a step for administering a candidate drug of the Parkinson's disease medicine to the Parkinson's disease animal model and a step for observing the degree of mitigation of Parkinson's disease symptoms to determine the treatment effect of the candidate drug on Parkinson's disease.

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MICROFLUIDICS FOR ANALYTE DETECTION BASED ON THE LIGHT TO HEAT CONVERSION PROPERTIES OF METAL NANOPARTICLES

Nº publicación: RU2018137413A 29/04/2020

Solicitante:

НАНОИММУНОТЕКСЛ

JP_2019515310_A

Resumen de: WO2017167769A1

The present invention refers to the in vitro use of a microfluidic kit or device comprising a support or substrate, wherein said support or substrate comprises at least one channel in the substrate, the channel comprising an inlet, an outlet, and a flow-path connecting the inlet and outlet, wherein the inlet and outlet together define a midplane; and a portion of the flowpath travels transversely across the midplane, wherein the portion of the flowpath that travels transversely across the midplane includes a recognition site or sensing area for detecting a target analyte; for detecting an analyte as a result of the heat generated by metal nanoparticles when they are irradiated with an external light source.

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