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resultados
Última actualización
20/05/2024 [07:20:00]
Resumen de: CN118044898A
本发明公开了一种无托槽矫治器配合下的正畸正颌终末合板及制备方法，属于骨性畸形治疗结构的技术领域，包括马蹄形合板，马蹄形合板包括导板上颌面、导板下颌面、导板唇外侧和导板唇内侧，且导板上颌面和导板下颌面之间的距离为整个牙冠高度的三分之二，通过本发明，实现了在正畸正颌联合治疗的术后一到两个月内，可以对颌位起到固定的作用，同时包绕牙面的三分之二和无托槽隐形矫治器附件，起到正畸保持器的作用，有效的防止牙齿在拆除合板到开口两指的期间，出现了牙齿移位的情况，保证了矫治器的正常佩戴，方便患者自行佩戴，且避免医用级光敏树脂材料的特性而造成佩戴困难的问题。
Resumen de: US2023115195A1
An additive manufacturing system and method for making components having filaments formed by elastomeric materials. A liner includes the filaments formed by an elastomeric material and is adapted for a prosthetic device system. The filaments form an elastomeric lattice structure and solid layers or features and define a ventilated structure permitting a transfer of air and moisture from an interior volume of the liner to an exterior or ambient liner. The liner may incorporate an adhesive and a textile layer secured to the elastomeric lattice structure and further define recesses and other features for improving a liner.
Resumen de: WO2024100147A1
A load-carrying rod (1) for an implant system has a structure of individual interconnected solidified droplets (4) so that the transitions from one droplet to another act as crack stoppers in the event of a crack.
Resumen de: WO2024102992A2
A device comprising a piezoelectric solid and a miniaturized electronic device; wherein the piezoelectric solid comprises a polymer and metal oxide nanoparticles and has a platonic solid shape; wherein a face of the piezoelectric solid comprises a concentric void; and wherein the miniaturized electronic device is placed inside the concentric void.
Resumen de: WO2024098119A1
A detachable printhead for a bioprinter is disclosed, the detachable printhead comprising a body, removably attachable to a fixed portion of the bioprinter; a dispensing system, supported by the body; one or more reservoirs, for holding one or more biomaterials, in fluid communication with the dispensing system, supported by the body; and a coupling for attaching to the fixed portion of the bioprinter, the coupling including an interface for operating the dispensing system.
Resumen de: AU2022379458A1
A method of printing a hydrogel scaffold is provided which includes providing a container containing an ink and a liquid that is immiscible with the ink; applying light from a light source to the ink to form a portion of the hydrogel scaffold, and applying light from a light source one or more additional times to produce one or more additional portions of the hydrogel scaffold.
Resumen de: US2024157024A1
This disclosure generally relates to a ceramic scaffold. This disclosure particularly relates to a ceramic scaffold useful for bone regenerations. This disclosure also relates to a ceramic scaffold comprising hydroxyapatite (HA), tricalcium phosphate (TCP), or a mixture thereof. This disclosure also relates to a ceramic scaffold with high mechanical strength and flexibility. This disclosure further relates to a ceramic scaffold manufactured through a three-dimensional (3D) printing process, methods of manufacturing a ceramic scaffold and methods of replacing bone in a subject using the ceramic scaffold.
Resumen de: US2024156739A1
The present invention utilizes 3D printing technology, specifically fused filament fabrication (FFF) 3D printing, to produce solid dosage forms, such as pharmaceutical tablets. The production process utilizes novel printing filaments, typically on a spool, which contain the active ingredient. Such active-containing filaments have proved to be extremely robust and the principles outlined in the present disclosure provide access to a variety of viable formulations directly from a 3D printer. This, for the first time, affords a viable means for the in situ (e.g. within a pharmacy) 3D printing of personalized medicines tailored to a patient's needs. The invention also relates to purpose-built software for operating the printing apparatus, as well as local, national and global systems for monitoring the real time operation of a plurality of printing apparati to enable facile detection of malfunctions, thereby making regulatory approval viable and facilitating regulatory compliance.
Resumen de: WO2024099485A1
A method of manufacturing of a vibrator according to a real master, comprising non-invasive, contactless and convenient home 3D scanning of the penis shape and subsequent manufacturing of its faithful replica in an industrial manner, including a step consisting 3D scan of a master of a penis using a mobile device, usually mobile phone or tablet, wherein the 3D scan of the master is created using available application software. The scanning is performed by convenient use of the LiDAR system and/or that the 3D model of the master is formed using image sensors, either with ToF (Time of Fly) technology or a photogrammetry - a method consisting of a 3D model composition from input 2D photographs. Conveniently, it comprises the step wherein the data are exported to an STL format that is directly applicable in conventional 3D printing. The invention is applicable in manufacturing of sexual aids and - as a product - in particular as a sexual aid/erotic toy.
Resumen de: US2024156605A1
A method of forming an implant having a porous tissue ingrowth structure and a bearing support structure. The method includes depositing a first layer of a metal powder onto a substrate, scanning a laser beam over the powder so as to sinter the metal powder at predetermined locations, depositing at least one layer of the metal powder onto the first layer and repeating the scanning of the laser beam.
Resumen de: US2024157629A1
Bioprinters use biological inks (i.e. bioinks) to produce biomaterials such as cell cultures (including 3D cell cultures), living tissues, and organs. Bioprinters as described by the present invention include those capable of performing high-throughput industrial scale assays, applications, and development while maintaining precision.
Resumen de: US2024156492A1
A minimally invasive system using a surgical robot as a three-dimensional printer for fabrication of biological tissues inside the body of a subject. A preoperative plan is used to direct and control both the motion of the robot and the robotic bio-ink extrusion. The robotic motion is coordinated with the ink extrusion to form layers having the desired thickness and dimensions, and use of different types of ink enables composite elements to be laid down. Such systems have a small diameter bio-ink ejecting mechanism, generally in the form of a piston driven cannula, enabling access to regions such as joints, with limited space. The robotic control is programmed such that angular motion takes place around a pivot point at the point of insertion into the subject. The bio-inks can be stored in predetermined layers in the cannula to enable sequential dispensing from one cannula.
Resumen de: US2024156468A1
A resection guide locator includes a bone engagement portion with surfaces that are complementary to the surface topographies of a bone to be resected during surgery. A housing includes a socket defined by a resilient annular wall that is sized and arranged so to accept a resection guide by press-fit to thereby position and hold the resection guide within the socket. The resection guide is maintained in a predetermined, preferred position while the surfaces are releasably locked in position on the bone. A method is disclosed for forming and using the resection guide locator.
Resumen de: US2024158758A1
Provided herein are synthetic living tissue structures comprising multiple layers of fibers deposited in solidified form from a 3D bioprinter, together with kits and methods of use related thereto. The fibers comprise a plurality of mammalian cells dispensed within a solidified biocompatible matrix. The structural integrity of the fiber is maintained upon and after deposition without any additional crosslinking. The fiber is continuously bioprinted through at least two layers of the structure. In one aspect, synthetic muscle tissue structures exhibit a readily assayable contractile functionality.
Resumen de: WO2024102853A1
Compositions and methods for delivery of therapeutic agents to an individual in need thereof, for prevention/reduction of tissue adhesion, and for 3D printing are disclosed herein. In some embodiments, the composition comprises octadecyl modified hydroxypropyl methylcellulose (HPMC-C18) and a surfactant or cyclic polysaccharide, wherein the composition is a hydrogel that exhibits dynamic properties.
Resumen de: US2024157651A1
A method for making a rapid prototype of a patient's mouth to be used in the design and fabrication of a dental prosthesis. The method takes an impression of a mouth including a first installation site having a dental implant installed in the first installation site and a gingival healing abutment having at least one informational marker attached to the dental implant. A stone model is prepared based on the impression, including teeth models and model markers indicative of the at least one informational marker. The model is scanned. Scan data is generated from the scanning. The scan data is transferred to a CAD program. A three-dimensional model of the installation site is created in the CAD program. The at least one informational marker is determined to gather information for manufacturing the rapid protocol. Rapid prototype dimensional information is developed. The rapid prototype dimensional information is transferred to a rapid prototyping machine which fabricate a rapid prototype of the patient's dentition as well as a dental implant analog position.
Resumen de: EP4368215A1
The present invention relates to a resorbable device for bone regeneration comprising a main body of bioresorbable polymeric material, wherein said main body comprises at least a portion for anchoring said device to a portion of alveolar bone, wherein said main body comprises at least an osteoconductive substance selected from: hydroxyapatite and/or tricalcium phosphate in alpha or beta form, brushite, monetite, or mixtures thereof.The device according to the present invention, has the advantages of being an easy-to-graft bone regeneration device that does not require preoperative device modeling and does not require the removal thereof by means of a second surgical operation.
Resumen de: CA3226174A1
Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.
Resumen de: EP4368214A1
The invention describes an intelligent three-dimensional biomimetic structure and the use thereof in the regeneration of bone tissue after a trauma or cancer situation.Said intelligent three-dimensional biomimetic structure is comprised of filaments constituted by polymers mineralized with hydroxyapatite, which are able to mimic the bone tissue in terms of composition, morphology, and mechanical properties.
Resumen de: AU2022308624A1
The present invention relates to a process for the preparation of a solid pharmaceutical administration form comprising mesoporous silica using a 3D printing process. The process is a printing process that allows the production of solid pharmaceutical administration forms comprising drug loaded mesoporous silica in an easy and flexible manner and in conformity with the high-quality standards required for the production of pharmaceutical
Resumen de: WO2023281031A1
The instant invention relates to a printable material for Hot Melt Extrusion- based 3D printing (HME-3DP) comprising a pregelatinized cross-linked starch and hydroxypropyl methyl cellulose (HPMC). It also relates to a process for 3D printing using the same. It also relates to products, in particular controlled release solid dosage forms, obtained thereof by 3D printing.
Resumen de: CN117615897A
The present invention relates to a printable material for 3D printing, the printable material comprising a hydrolyzed and functionalized starch compound. The invention further relates to a method for conducting 3D printing through the 3D printer. The invention also relates to products thus obtained by 3D printing, in particular solid dosage forms.
Resumen de: US2023008260A1
Network enabled 3D printing and automated processing techniques for oral devices are disclosed herein. An example technique includes receiving, via a network, a data file representative of a mouth of a user, and printing, by a 3D printer, a 3D oral device based on the data file. The example technique may further include automatically ejecting, from the 3D printer, the 3D oral device, and scanning the 3D oral device to generate a 3D scan file of the 3D oral device. The example technique may further include comparing the 3D scan file with the data file to determine at least one feature represented in the 3D scan file that exceeds a deviation threshold relative to a corresponding respective feature represented in the data file; and finishing, by a finishing module, the 3D oral device by smoothing the at least one feature on the 3D oral device.
Resumen de: CN220938299U
本实用新型涉及医疗器械技术领域，特别涉及一种定制化3D打印颅骨缺损保护支具。本实用新型的定制化3D打印颅骨缺损保护支具包括3D打印防护板，所述3D打印防护板的两端设有连接点，两个所述连接点之间连接有束缚带。优点：结构设计简单、合理，能够有效的保护颅骨缺损部位，促进患者的恢复。
Resumen de: CN118027350A
本发明提供了一种脂肪族聚酯型聚氨酯丙烯酸酯及其制备方法和应用、3D打印光固化材料及其制备方法和应用，涉及牙科材料技术领域。本发明提供的脂肪族聚酯型聚氨酯丙烯酸酯不含苯环苄基结构，‑NOC与‑OH形成氢键结构，显著提高了脂肪族聚酯型聚氨酯丙烯酸酯的刚性，避免其出现黄变现象；酯基提供优异的韧性和抗变形能力，且无吸水性；氢键和酯基的共同作用形成坚韧性能优异的脂肪族聚酯型聚氨酯丙烯酸酯，抗断裂性和抗变形能力优异；六元环空间占位大，可降低固化后的体积收缩率，抗变形能力优异。本发明提供的脂肪族聚酯型聚氨酯丙烯酸酯能显著降低3D打印光固化材料的吸收性，提高其韧性、抗断裂性和抗变形性。
Resumen de: CN118022054A
本发明公开了一种可个性化定制骨缺损修复材料及其制备方法。该修复材料以动物来源提取的胶原蛋白、脱钙骨基质及钛酸钡复合，通过3D打印技术低温成型制成。本发明以胶原蛋白作为框架材料，以成骨性能良好的脱钙骨基质作为硬质材料增强材料力学支持，以具有良好压电效应的钛酸钡和甘氨酸作为电响应材料，制备一种可个性化定制的骨缺损修复支架，促进骨组织愈合，提高缺损处的成骨能力。
Resumen de: CN118027300A
本发明公开了一种光固化3D打印用的透明高强韧光敏树脂材料及其应用。本发明提供一种光固化3D打印用透明高强韧光敏树脂材料，按质量百分数计，包括如下组分：17％～21％低聚物1；15％～18％低聚物2；20％～25％低聚物3；13％～16％低聚物4；8％～15％活性稀释剂1；7％～12％活性稀释剂2；3％～7％活性稀释剂3；1％～2％光引发剂。本发明通过几种特定的低聚物与活性稀释剂的复配使用，利于3D打印制备隐形正畸产品，各组分之间相容性好，材料的耐黄变好、硬度与柔韧性优异，不仅能提高3D打印成品的精度，还提高了3D打印产品的交联网络的密度、力学强度、热稳定性和抗紫外老化性能，能达到用于隐形正畸的高透明、强韧要求。
Resumen de: CN118022061A
本发明提供一种基于喷墨打印的生物墨水及其制备方法和应用，所述生物墨水通过混合生物墨水组合物中的各组分而得到，所述组合物包括分散介质和生物单元；所述分散介质包括水凝胶交联前体和水凝胶粘附增强剂。本发明的生物墨水的粘度可调控范围较大，能确保高精度墨滴(微米级)、微量(纳升级)的打印性能；适用于多种材料表面、内部(如水凝胶、水、高分子等内部)打印；墨水组合物在0‑40℃下为液体，适用于0‑40℃的打印，在0‑40℃下打印时均不会堵塞针头，能够降低打印成本；可实现点、线、面、体的打印；可实现多种图案化的打印。
Resumen de: CN118021492A
本发明提供了一种4D打印管腔支架及其制备方法，所述管腔支架包括支架主体和载药层；所述支架主体采用非均匀韧带手性结构；其中，所述非均匀韧带手性结构中包括韧带结构和锯齿结构；所述支架主体与所述载药层均包括可生物降解的形状记忆聚合物；所述载药层还包括药物。本发明提供的4D打印管腔支架具有非线性J形应力‑应变行为，还能实现对管腔支架力学性能的调控。
Resumen de: CN118023540A
本发明涉及一种无粘粉粗糙表面的3D打印多孔金属植入体及其制造方法。本发明植入体具有内部互相连通的多孔网格状金属骨架，以及呈沟槽状的微米级粗糙金属骨架表面。所述多孔网状金属植入体经振动、水洗、气吹、超声和等离子抛光等净化处理后，植入体网格骨架表面和内部残留的未熔融金属粉末可以被高效去除。本发明植入体在植入人体后可避免因摩擦和体液腐蚀等原因引起的植入体表面不良粘附粉体脱落问题，减少有害金属离子的溶出；同时呈沟槽结构的微米级粗糙表面可以更好的促进细胞在植入体多孔结构表面的粘附、迁移和生长，赋予植入体更好的骨整合性能和长期使用安全性。
Resumen de: CN118021473A
本发明公开了一种新型预备导板模型构建方法及制作方法，所述方法包括利用软件，在牙列缺损数字化模型上可摘局部义齿的就位道方向；在数字化模型邻牙内侧参考就位道方向标注限位区域和邻牙内侧导平面；根据数字化模型中的缺牙区、邻牙、邻牙内侧的导平面、限位区域及待磨除区域生成预备导板模型。基于所生成的模型采用3D打印方法制备预备导板。本发明更好解决了现有技术中可摘局部义齿设计的就位道方向与实际口内预备的导平面方向不一致，影响义齿固位和稳定效果的问题。通过该方法，可以在数字化模型上提前完成导平面的预备，并根据导平面完成可摘局部义齿的数字化设计和制作。
Resumen de: CN118022052A
本发明公开了基于AI调控微力学和中药缓释的3D打印软骨材料制备方法，涉及软骨材料制备技术领域。该基于AI调控微力学和中药缓释的3D打印软骨材料制备方法，基于AI调控微力学和中药缓释的3D打印软骨材料制备方法包括以下步骤；本申请通过将含氨基和羧基的水溶性多糖与编码有生长因子的DNA载体在中药缓释溶液混匀，得到混合溶液，能够有效的将含氨基和羧基的水溶性多糖与编码有生长因子的DNA载体与中药缓释溶液成分混合，使中药缓释溶液中的药物成分能够成分进入到含氨基和羧基的水溶性多糖与编码有生长因子的DNA载体的内部，加强药物治疗效果，效果较好。
Resumen de: CN118022048A
本发明公开了一种磁场下精准导航的4D打印磁性支架及其制备方法与应用，其属于生物材料技术领域，其中，磁场下精准导航的4D打印磁性支架的制备方法包括以下步骤：将聚乳酸‑羟基乙酸共聚物加入到溶剂中溶解后，再加入羟基磷灰石粉和Fe3O4@SiO2粉末进行分散，得到墨水；将墨水使用3D打印机进行打印，得到所述4D打印磁性支架。本发明制得的4D打印磁性支架，具有理想的光热转换作用并且具备较强的磁性，这一特性能有效的促进骨修复，以及可以通过对808nm近红外光的照射的时间和功率的控制，采用非接触式诱导加热的方式将光能量转换成热能，实现对材料温度的精准控制。
Resumen de: CN118022051A
本发明提供一种多级孔聚己内酯复合骨支架及其制备方法和应用，属于生物高分子材料技术领域；该多级孔聚己内酯复合骨支架的制备方法包括：(1)将聚己内酯、有机材料及无机材料混合并溶于有机溶剂，得混合浆料；(2)将混合浆料进行3D打印，得支架前体；(3)将支架前体干燥灭菌后进行酶处理，即得。本发明的多级孔聚己内酯复合骨支架表面多孔且粗糙度高，利于细胞在其表面的粘附和浸润性生长，同时可提高有机材料和无机材料的表面暴露程度，具有促进细胞生长和骨组织修复的作用，在人工支架材料及骨组织工程修复材料的制备中具有较好的应用前景。
Resumen de: WO2024094890A1
An implant for cartilage and meniscus repair and formed from decellularized cartilage extracellular matrix (dECM) ink is described. The dECM ink has a dECM concentration of 5 to 10% (w/v), preferably a pH of 10-12, and the dECM in the implant is chemically crosslinked. The implant may be fibrous and formed by 3-D printing fibres with the dECM ink to form a fibrous 3-D construct, or it may be formed by casting the dECM ink in a mould. The dECM may include 50 to 350 mM salt. Implants made of tissue-specific dECM can recapitulate the inherent microenvironmental niche of cells, promoting a tissue-specific phenotype. Freeze-drying the implant and then crosslinking the freeze-dried implant has been found to provide an implant with improved mechanical properties.
Resumen de: FR3141674A1
L’invention porte sur un procédé de fabrication d’une selle de deux-roues, du type comprenant une armature (4) et un support d’utilisateur (3), caractérisé par les étapes suivantes : - appliquer une matière de moulage sur une armature (4) de selle, - réaliser une prise d’empreinte du fessier d’un utilisateur sur une face d’assise de la matière de moulage, - insérer au moins un élément élastique (1) sur la face d’assise de la matière de moulage à au moins une position présentant une pression localement accrue identifié lors d’un test d’assise initiale, - réaliser un test d’assise de validation par l’utilisateur, - déposer l’au moins un élément élastique (1) de la matière de moulage de sorte que la matière de moulage présente au moins une cavité (2), - relever la forme externe de la matière de moulage présentant l’au moins une cavité (2), - fabriquer le support d’utilisateur (3) présentant la forme externe relevée. Figure à publier avec l’abrégé : Fig. 1
Resumen de: WO2024094275A1
The present invention relates to a method for interactively designing via an implant design platform an artificial joint implant for hip arthroplasty and corresponding broaching and osteotomy guide apparatuses. The proposed implant design platform reconstructs the anatomy of the patient's pelvic and femoral bones in a 3D digital environment, and accordingly develops a patient-specific femoral implant stem as well as patient-specific surgical tools broach/rasp, osteotomy guide) used in total hip arthroplasty. The patient-specific femoral implant stem developed may be optimized to ensure optimum mechanical performance for the patient, employing complex internal lattices that minimize stress shielding and advanced trabecular surfaces to promote osseointegration.
Resumen de: US2024108297A1
The present invention provides methods and devices for making an anti-scatter grid for a radiographic imaging device identifiable. A method for providing an anti-scatter grid (100) for a radiographic imaging device comprises forming, by an additive manufacturing process, a grid pattern (110) in accordance with a product specification of the anti-scatter grid (100) to be provided; and forming, by an additive manufacturing process, a number of structural modifications (121) in or at the grid pattern in a manner making the number of structural modifications (121) image-based recognizable when the anti-scatter grid (100) is viewed according to its intended use in a viewing direction from a radiation source of the radiographic imaging device, and in a unique identification pattern (120) creating a unique identifier to make the anti-scatter grid to be provided identifiable among one or more others.
Resumen de: CN220917447U
本实用新型公开了一种3D打印新型血管连接器组件，包括连通管和固定环，连通管具有两个以上的连通口，连通管的直径为测量的血管的内径，在连通管上靠近连通口的端部均具有用于安装固定环的环形凸起。环形凸起的直径比连通口的直径大1mm，固定环的宽度为1mm，固定环的内直径等于环形凸起直径。解决现有的血管缝合操作困难且缝合完成度不稳定的问题。
Resumen de: CN118002801A
本发明涉及金属牙冠打印技术领域，尤其涉及一种金属牙冠的3D打印制备方法，本发明通过确定牙齿咬合面上若干采集点在预设方向上的坐标值，以绘制坐标值的正态分布曲线，根据正态分布曲线确定热量显性坐标值区间，通过在逐层打印金属牙冠过程中获取热量显性坐标值区间内各打印层的温度变化曲线，计算熔化热量影响表征系数，以判定热量显性坐标轴区间内打印层的热量表现是否异常，并选定对打印参数的调整方式，最后，逐层打印得到目标金属牙冠，进而，实现了根据牙齿咬合面的数据信息对热影响叠加区域进行筛选，数据化直观表征层间热影响程度，以及适应性地调整牙齿咬合面复杂区域的打印过程参数，保证了牙冠整体性能的一致性。
Resumen de: WO2024097752A1
Manufacturing a dental part with volumetric units that vary in translucency, shading and/or color. A beam translation module of a 3D printing system is used to translate an input pattern into an output for controlling a spatial structuring of light for 3D printing an object from a resin material that is sensitive to light intensity, light color or light exposure time.
Resumen de: CN118001221A
本发明公开了一种光固化水凝胶复合微针，所述光固化水凝胶复合微针的原料包括光引发剂、光固化水凝胶单体和生物活性玻璃；按质量百分比计，所述生物活性玻璃包括40wt％‑50wt％的SiO2、23wt％‑27wt％的Na2O、23wt％‑27wt％的CaO和4wt％‑6wt％的P2O5；按质量百分比计，所述光固化水凝胶复合微针的原料中，所述光引发剂和光固化水凝胶单体的含量之和为70wt％‑80wt％，所述生物活性玻璃的含量为20wt％‑30wt％。本发明制备方法简单，制备的光固化水凝胶复合微针有着优异的物理机械性能，针头能够有效刺破皮肤，协助输送药物至真皮层。
Resumen de: CN118001461A
本发明属于3D打印生物材料技术领域，具体涉及一种用于“一步法”原位实时3D打印的胶原蛋白生物墨水及其制备方法和应用。所述胶原蛋白生物墨水由胶原蛋白溶液、甲基丙烯酸酐和光引发剂混合制成，在405nm波长的蓝光照射下进行固化；所述胶原蛋白生物墨水具有良好的可挤出性能，可以3D打印得到精细的微米级结构；所述胶原蛋白生物墨水打印的生物支架具有良好的生物相容性和生物活性，能显著促进皮肤损伤的修复。
Resumen de: CN118000973A
本发明提供了一种仿生梯度支架的制备方法及仿生梯度支架，包括如下步骤：步骤1：对大段骨缺损部位进行扫描，获取缺损区域数据，将所获取的数据导入建模软件中重构形成骨缺损三维模型；步骤2：基于所重构的骨缺损三维模型，确定骨缺损部位的相关参数，在建模软件中模拟植入位点及虚拟骨尺寸，生成能够覆盖骨缺损部位的梯度支架的三维结构模型；步骤3：将梯度支架的三维结构模型导入建模软件进行切片，切片后数据导入3D打印设备，打印生成梯度支架；步骤4：对打印生成的梯度支架进行冷却，除去支撑结构，对梯度支架的表面进行抛光处理。本发明的镁合金骨组织工程支架具有三维联通性好、孔径孔隙率可控和孔隙形状精度高、梯度结构仿生的特点。
Resumen de: WO2024097682A1
An indirect bonding (IDB) tray that can be positioned over a single tooth of a patient. The IDB tray can include a well to receive an orthodontic bracket therein. The IDB tray can be 3D printed with a rigid photopolymer material and a soft photopolymer material. The soft photopolymer material may be disposed on a gingival portion of the IDB tray such that the soft photopolymer material can be positioned proximate the gums of the patient to improve patient comfort and/or accommodate gum remodeling due to tooth movement. The soft photopolymer material may be disposed around an inner periphery of the well to facilitate bracket insertion and/or release from the well. The IDB tray can include separation indicia indicating where the IDB tray can be sectioned. The IDB tray can include long axis lines to indicate proper orientation of the IDB tray on a patient's one or more teeth.
Resumen de: WO2024097183A2
A method of fabricating a removable dental appliance includes the steps of: (a) acquiring 3D digital image data of a patient's mouth and dentition; (b) creating a 3D digital model of a removable dental appliance to be fabricated wherein the 3D digital model incorporates a model clasp and/or model seat selected from a digital library of virtual clasps and/or seats, each of the virtual clasps or seats corresponding to an associated physical clasp or seat; (c) fabricating a portion of the removable dental appliance from the 3D digital model, the portion of the removable dental appliance including an attachment section; (d) selecting a physical clasp or seat that corresponds to the model clasp or seat; and (e) inserting a tail section of a selected physical clasp and/or seat into mounting structure in the attachment section, the tail section being dimensioned to matingly engage the mounting structure to assemble the selected physical clasp and/or seat to the attachment section of the removable dental appliance.
Resumen de: WO2024093647A1
Three-dimensional (3D) printing methods for making metal-embedded medical implants and devices are provided. The newly developed 3D printing technology and surface modification method will contribute to the wider application of 3D-printed patient-specific products in many medical fields showing excellent clinical safety.
Resumen de: CN118005839A
一种用于制备牙科假体的可自由基聚合材料，其包含(a)至少一种单官能可自由基聚合的(甲基)丙烯酸酯，(b)至少一种多官能可自由基聚合的(甲基)丙烯酸酯，(c)至少一种ABA三嵌段共聚物，(d)至少一种平均一次粒度为10纳米至350纳米的纳米颗粒或微细填料，和(e)至少一种光引发剂。ABA三嵌段共聚物的A嵌段是低聚聚酯，B嵌段是低聚聚硅氧烷。
Resumen de: US2024150580A1
An advanced manufactured interpenetrating polymer network (AM-IPN) comprising: a primary polymer network; a secondary polymer network, wherein the secondary polymer network is bonded to the primary polymer network via one or more crosslinks, wherein one or more of the primary polymer network, the secondary polymer network and the one or more crosslinks are printed using a synthetic bioink is disclosed. Methods of making and using are also disclosed.
Resumen de: US2024150510A1
Disclosed are a photo-curable resin composition, and a molded article manufactured therefrom, the photo-curable resin composition comprising: 60-80 parts by weight of a (meth)acrylated urethane-based polymer; 10-30 parts by weight of a (meth)acrylate-based compound including at least one C3-C20 cyclic alkyl group; and 1-3 parts by weight of a photopolymerization initiator.
Resumen de: US2024149523A1
Methods to fabricate objects by 3D printing of poly-4-hydroxybutyrate (P4HB) and copolymers thereof have been developed. In one method, these objects are produced by continuous fused filament fabrication using an apparatus and conditions that overcome the problems of poor feeding of the filament resulting from the low softening temperature of the filament and heat creep along the fed filament. Methods using an apparatus including a heat sink, a melt tube, a heating block and nozzle, and a transition zone between the heat sink and heating block, with the melt tube extending through the heat sink, transition zone, and heat block to the nozzle are disclosed. 3D objects are also printed by fused pellet deposition (FPD), melt extrusion deposition (MED), selective laser melting (SLM), printing of slurries and solutions using a coagulation bath, and printing using a binding solution and polymer granules.
Resumen de: US2024148479A1
Manufacturing a dental part with volumetric units that vary in translucency, shading and/or color. A beam translation module of a 3D printing system is used to translate an input pattern into an output for controlling a spatial structuring of light for 3D printing an object from a resin material that is sensitive to light intensity, light color or light exposure time.
Resumen de: US2024148936A1
A scaffold for tissue regeneration, particularly for bone regeneration, comprises a three-dimensional supporting structure made of a biocompatible and biodegradable material; the supporting structure is functionalized with secretome, in particular mesenchymal stem cell secretome, preferably in lyophilized form (lyosecretome).
Resumen de: US2024148942A1
A scaffold for bone regeneration comprises a three-dimensional support structure made with a composite hybrid formed by a bovine bone-derived matrix reinforced with a polymer and containing collagen fragments; the support structure is functionalized with secretome, in particular mesenchymal stem cell secretome, in lyophilized form (lyosecretome).
Resumen de: US2024148657A1
The present invention utilizes 3D printing technology, specifically fused filament fabrication (FFF) 3D printing, to produce solid dosage forms, such as pharmaceutical tablets. The production process utilizes novel printing filaments, typically on a spool, which contain the active ingredient. Such active-containing filaments have proved to be extremely robust and the principles outlined in the present disclosure provide access to a variety of viable formulations directly from a 3D printer. This, for the first time, affords a viable means for the in situ (e.g. within a pharmacy) 3D printing of personalized medicines tailored to a patient's needs. The invention also relates to purpose-built software for operating the printing apparatus, as well as local, national and global systems for monitoring the real time operation of a plurality of printing apparati to enable facile detection of malfunctions, thereby making regulatory approval viable and facilitating regulatory compliance.
Resumen de: US2024149522A1
Described herein are apparatuses, systems, and methods for fabricating tissue constructs, such as by fabricating perfusable tissue constructs by embedding a sacrificial material into a composite matrix yield stress support bath. A composite matrix bath can include a microgel filler and a hydrogel precursor. An extrusion tip can be used for embedded printing of perfusable tissue constructs by disposing sacrificial material into the composite matrix bath while the extrusion tip travels along a predefined course through the composite matrix bath. This sacrificial material can be the printed tissue construct or can be removed to render the matrix bath a perfusable tissue construct. The composite matrix bath can include acellular or cell-laden hydrogels. The sacrificial material can include a salt and a physiological buffer or a non-cytotoxic porogen material. The hydrogel precursor can include at least one of gellan and gelatin. Cross-linking can be carried out chemically, thermally, enzymatically, or physically.
Resumen de: AU2022304563A1
A bellows shaped spinal implant, comprising an upper plate having an upper opening therethrough, a lower plate having a lower opening therethrough, and aa bellows shaped shell extending between and joining the upper plate and the lower plate. The bellows shaped shell is formed of titanium or an alloy comprising titanium and includes a wall extending continuously therearound that defines a hollow interior in communication with the upper opening and the lower opening. The wall has a thickness in the range of 0.5 mm to 1.0 mm to provide for radiographic imaging through the wall. The wall is angled or curved inwardly or outwardly between the upper plate and the lower plate to provide stiffness that mimics the stiffness properties of a similarly sized polyetheretherketone (PEEK) implant.
Resumen de: CN117412720A
A method includes acquiring image data of an abnormal site in a blood vessel, generating a model of a biological implant from the image data, and forming the biological implant from the model, where the biological implant is sized to correspond to the abnormal site. Such a method may include introducing a biological implant in an abnormal site.
Resumen de: EP4241816A2
A patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to a patient's airways including at least entrance of a patient's nares. The patient interface is configured to maintain a therapy pressure in a range of about 4 cmH2O to about 30 cmH2O above ambient air pressure in use, throughout a patient's respiratory cycle, while the patient is sleeping. To ameliorate sleep disordered breathing, the patient interface comprises a cushion assembly including: a plenum chamber and a seal-forming structure having a sealing portion constructed and arranged to form a pressure-assisted seal with a region of the patient's face surrounding an entrance to the patient's airways inferior to a nasal bridge region of the patient's face. The seal-forming structure includes a flexible support structure and a seal biasing portion, wherein the seal biasing portion is configured to inflate upon pressurization of the cavity in use.
Resumen de: CN220898849U
本实用新型公开了一种用于义齿生产的扫描仪，包括：所述电控导轨嵌合安装在所述扫描仪外壳内部，且所述扫描拍摄仪滑动连接在电控导轨与扫描仪外壳的外侧边上，并且所述置物托盘设置在扫描仪外壳的圆心内部，同时扫描仪外壳为中空的圆柱形形状，还包括：支撑底架，其固定安装在所述置物托盘的底侧面上，且所述支撑底架的底部固定连接有支撑柱，调节轴杆，其中段处转动安装在所述支撑柱的底端上，且所述调节轴杆的左右两端处分别连接有调节臂架，并且调节臂架的上端处连接有夹爪。该用于义齿生产的扫描仪，能以围绕模型拍摄的方式进行扫描，还能在扫描过程中保持石膏义齿模型的稳定，以避免义齿模型在扫描测量中晃动歪斜。
Resumen de: CN117982722A
本发明公开了还原氧化石墨烯神经导管和促进周围神经再生装置，属于组织工程技术领域。本发明的还原氧化石墨烯神经导管，制备的原料包括顺磁性材料和凝胶。本发明构建一种模拟周围神经层次结构的神经导管，极大提高了神经导管的仿生程度及生物相容性。本发明使用3D打印技术，在模拟神经鞘膜固有生物成分的前提下，向复合材料中加入rGO以增强电生理学性能，构建不同配方复合材料，促进神经损伤电生理紊乱的恢复。本发明利用磁场可以作为一种无创的可控生物刺激引导神经生长，其与rGO结合可产生协同作用增强rGO生物学效应。减少了术后并发症的可能，可以增加神经损伤修复后的修复效果。
Resumen de: CN117983832A
本发明涉及一种无粘粉高光泽3D打印多孔金属骨植入体及其制作方法，属于增材制造骨科医疗器械领域。该金属植入体具有与病变切除部位精准匹配的外形结构，内部互相连通的多孔网格阵列，以及无粘粉高光泽的金属网格骨架。所述多孔网状金属植入体经振动、水洗、气吹、超声和等离子抛光等净化处理后，植入体网格骨架表面和内部不良附着的残余金属粉末可以被高效去除；显微镜下观察可发现，多孔金属骨植入体网格骨架由处理前金属粉末粘附堆积形成的粗糙结构转向处理后的无粘粉高光泽结构。本发明植入体在植入人体后可避免因摩擦和体液腐蚀等原因引起的植入体表面不良粘附粉体脱落问题，减少有害金属离子的溶出，提高植入体的长期使用安全性。
Resumen de: CN117983829A
本发明涉及医疗器械制备领域，公开了一种3D打印基于仿生结构含铜钛网的制备方法。通过成分改性，添加了金属铜，利用3D打印的方式，制备出含铜钛网本体的调节骨组织重建愈合的拓扑结构面和软组织重建愈合的拓扑结构面。纳米级复杂多孔拓扑结构、适中的纳米级粗糙度等拓扑结构的设计有助于增加成骨细胞活性、细胞粘附和增殖，促进硬组织重塑。铜离子可以通过激活巨噬细胞免疫应答，调控炎症反应启动血管化生物过程，促进血管内皮细胞迁徙成管，体内促进早期血管化，促进伤口愈合。同时，铜离子具有抗菌性，含铜植入体可以同时杀灭细并活化免疫细胞吞噬细菌，有效降低伤口感染率。
Resumen de: CN117985926A
本发明公开了一种具TPMS结构的生物活性玻璃支架及其制备方法和应用，属于生物医用材料技术领域。本发明公开的一种具TPMS结构的生物活性玻璃支架及其制备方法，该支架以光固化树脂、生物活性玻璃粉体混合为浆料，用Rhino设计支架的TPMS结构，并通过DLP打印技术制备，最终烧结成型，得到无结晶的多孔支架。本发明结合了生物活性玻璃和仿生TPMS结构设计，具有良好的生物相容性、力学性能以及成骨性能，可以应用于骨组织再生修复。
Resumen de: CA3226476A1
A method for manufacturing a photopolymerizable slurry comprises the steps of: providing a plurality of particles of an inorganic salt in the form of a powder; wherein at atmospheric pressure the inorganic salt has a melting point of above 250 °C; and wherein at room temperature the inorganic salt has a solubility in water above 9 %w/w; providing at least one radiation curable monomer; the at least one radiation curable monomer being in the liquid phase; and adding the inorganic salt particles to the liquid composition and mixing the inorganic salt particles with the liquid composition; obtaining a photopolymerizable slurry, selectively curing the photopolymerizable slurry to obtain a green body article; debinding the green body article to obtain a binderless body article; and sintering the binderless body article to obtain a sintered ceramic article; providing a first template mold (1); wherein the first template mold comprises the sintered ceramic article; providing a second mold (2, 2', 2"); wherein the second mold comprises a compartment into which said first template mold can be placed; mounting the first template mold into the compartment of the second mold, thereby obtaining an operative mold (1, 2, 2', 2"); casting a ?uid casting material (3, 3', 3") into said operative mold to obtain after solidi?cation of said casting material an infiltrated template mold (8) comprising a solid article (9) that is at least partially located within the ?rst template mold (1); and se
Resumen de: CN117982181A
本发明公开了基于4D打印技术的仿生藤蔓食道手术辅助牵引工具及其成型方法，包括由4D打印技术制成的仿藤蔓牵引工具和通过激光固化(SLA)制成的仿生杠板归倒刺层(耦合仿生)，仿杠板归倒刺层与仿藤蔓牵引工具固定连接。仿藤蔓牵引工具在常温状态下为平直状态，在人体内部温度激励下，可以自由发生弯曲，从而实现辅助牵引功能，牵引工具内部镂空，可以放入超弹合金，利用超弹合金自身的弹力将牵引工具变形。手术过程中仿杠板归倒刺层刺入食道并与其固定连接，在体温激励下仿藤蔓牵引工具变软，可自由变形，在超弹合金的作用下，仿藤蔓牵引工具和仿生杠板归倒刺层均发生卷曲并牵引病灶处的食道处。
Resumen de: CN117984549A
本发明公开了一种三维打印高分子基组织工程支架的制备方法，包括以下步骤：S1、将聚合物材料进行熔融处理，并搅拌混合均匀，利用熔融沉积技术进行三维打印，得到高分子基多孔支架；S2、采用大气压等离子射流技术对所述高分子基多孔支架进行表面修饰，得到表面活化的三维打印高分子基组织工程支架。本发明三维打印高分子基组织工程支架的制备方法将大气压等离子体处理技术应用于三维打印高分子基的表面改性处理，在避免其他表面处理技术问题发生的同时，可以改善高分子支架表面的亲水性和生物相容性，同时引入极性基团，实现高分子支架表面的官能团化，提高表面活性。
Resumen de: WO2023140537A1
A transparent orthodontic appliance and a manufacturing method thereof are disclosed. The disclosed transparent orthodontic appliance includes a tooth side surface contact portion, wherein the tooth side surface contact portion includes a tooth contact surface configured concavely and a tooth non-contact surface configured convexly which are arranged opposite to each other.
Resumen de: CA3216093A1
A system and method for forming a medical implant using a printing device. The printing device includes a print head having a heated nozzle, a heated build plate for receiving the printed material thereon, and a reflective plate having an active heater. A method for forming a medical device includes extruding a printing material by contiguous deposition to form a porous object having a lattice-like structure. The medical device, such as a spinal implant, may have interconnected pores and different regions, each having a different porosity for encouraging bone growth therein. The printed medical implant may be designed to be patient-specific, customized, and printed on-demand.
Resumen de: CN117964824A
本发明公开了一种多重刺激响应性均聚物及其制备方法和应用，多重刺激响应性均聚物的制备方法包括以下步骤：将N‑羟甲基丙烯酰胺、乙酸酐、碱和第一溶剂混合，反应后得到N‑乙酰氧基甲基丙烯酰胺，将N‑乙酰氧基甲基丙烯酰胺、缚酸剂、2‑甲氨基醇和第二溶剂混合，反应后得到羟基‑N‑甲基氨基丙烯酰胺，将羟基‑N‑甲基氨基丙烯酰胺、反应物、4‑二甲氨基吡啶和第三溶剂混合，滴加二环己基碳二亚胺的二氯甲烷溶液，反应后得到R‑N‑m‑AM，将R‑N‑m‑AM、RAFT链转移试剂、第四溶剂和引发剂混合，在氮气或惰性气体氛围中反应得到多重刺激响应性均聚物，多重刺激响应性均聚物可以应用在药物释放中，也可以应用在光刻图案中。
Resumen de: CN117959492A
本发明涉及骨修复技术领域，具体涉及一种基于形状记忆材料的骨组织支架及其制备方法。本发明制备出了具有“自适应”功能的基于形状记忆聚合物的4D打印电活性多孔骨组织支架，可以通过微创手术在高度压实的状态下植入目标位置，并在磁场等刺激下实现缺损填充。同时，该支架可以为骨缺损提供足够的支撑。此外，利用形状记忆聚合物的双向形状记忆行为，能够在一定的刺激条件下完成非接触式往复形变，具有形变可逆、频率可控、条件温和耐疲劳的特性，有助于在微重力条件下提供成骨所需的周期性应力。同时利用压电和摩擦电构筑体内的微电环境，促进骨细胞的生长和缺损的修复。本发明形状记忆骨组织支架具有巨大的临床转化潜力。
Resumen de: CN117958757A
本发明提供了一种介入式触觉传感器与应用方法，包括测头部、导管部、主机部和位移部，所述导管部连接测头部与主机部，基于波导的全内反射原理，利用“生‑机”接触过程中波导内部传输光功率随外部接触载荷大小变化的规律，来解决介入式触觉诊断中所要求的电无源性、小型化、大感测角、可调节的分辨力等核心问题，可对不同方位角保持测量一致性；其应用方法基于医疗数据库的触诊数据集训练深度学习模型算法，丰富的数据集使得该算法可以实现准确而高效疾病诊断和分期预测，以应对复杂多样的体内软组织环境，减少内窥镜的漏诊和误诊，从而能够实现疾病的“早发现，早治疗”，提高疾病的治愈率。
Resumen de: CN220893561U
本实用新型涉及医疗检查技术领域，具体为一种检查辅助装置，包括体重检测装置和身高检测装置和辅助记录装置，所述体重检测装置包括脚踏板，所述脚踏板的底端设置有数个压块，所述压块的底端设置有数个压力传感器，并且压力传感器安装于底座内，所述身高检测装置包括滑杆，所述滑杆上滑动连接有滑管，所述滑管连接有检测板，所述滑杆和滑管之间设置有容栅传感器，所述辅助记录装置包括支撑架，所述支撑架上设置有壳体，所述壳体内设置有无线信号接收模块、屏幕和小票打印机，通过小票打印机直接打印出身高和体重，使得儿童在检查时，不需要再去对设备进行读数再记录，而是直接拿取小票即可，大大提高了检测的效率，减少了检测的排队时间。
Resumen de: WO2024089564A1
A surgical robotic system includes a robotic arm having a surgical instrument. The surgical robotic system also includes a surgeon console including a pair of hand controllers for controlling the robotic arm and the surgical instrument. The system further includes a sensor, which may be 3D printed, disposed on tissue and configured to measure at least one parameter pertaining to the tissue. The system additionally includes a controller configured to receive sensor data from the sensor, the sensor data including the at least one parameter and control at least one of the robotic arm or the surgical instrument based on the sensor data.
Resumen de: WO2024092041A1
The present disclosure provides curable compositions comprising one or more of photo-polymerizable monomers as reactive diluents, as well as polymeric materials formed from the curable compositions. Further provided herein are methods of producing the compositions and using the same for the fabrication of medical devices, such as orthodontic appliances.
Resumen de: WO2024089051A1
The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.
Resumen de: WO2024091971A1
Described herein are compositions and methods for bone regeneration and the treatment of bone diseases, bone defects, and injuries to bone. The compositions and methods include treating bone regenerative implants with lyoprotectants to enhance their surface and mechanical properties and then gene- activate the resulting scaffolds to enhance bone regeneration.
Resumen de: WO2024087690A1
A microneedle device improving drug utilization. The microneedle device comprises a substrate (1) and several needle bodies (2) arranged in an array on the substrate (1). Each needle body (2) comprises a base (201), a needle tip portion (203), and a supporting and connecting portion (202), which connects the base (201) and the needle tip portion (203), wherein the base (201) is a truncated cone that has a bottom inclination angle of 15° to 50°; the needle tip portion (203) is a cone that has an apex angle of 15° to 40°; and a side surface of the supporting and connecting portion (202) is a concave curved surface. The microneedle device is suitable for 3D printing, and can solve the problems, in a conventional method for increasing the drug loading capacity by means of increasing the height and array density of microneedles, of it being difficult to penetrate skin due to an increase in the density of microneedles, and of an increase in pain due to the microneedles being too high.
Resumen de: WO2024088120A1
A tibial tray prosthesis, comprising a tibial tray platform (1) and a tibial tray stem (2). The tibial tray platform (1) has a proximal end surface (11) facing the tibia and a distal end surface (12) arranged opposite the proximal end surface (11), and the tibial tray stem (2) is fixedly connected to the proximal end surface (11) of the tibial tray platform (1). A porous 3D printed metal structure (10) is further provided on the proximal end surface (11) of the tibial tray platform (1), and the porous 3D printed metal structure (10) has a pore intercept length of 200 μm to 500 μm and a porosity of 50% to 80%, which reduces the stress shielding effect of the tibial tray prosthesis so as to mitigate problems such as reduced strength and delayed healing of bone caused by existing prostheses.
Resumen de: US2024144548A1
A novel form of a dental auto shade management, where a user interface and a system for use in determining shade of a patient's tooth is presented. The digital 3D representation includes color data and texture data for the tooth is obtained. A tooth shade value for at least one point on the tooth is determined and shown visually in a graphical format. Once the shade mapping is finished, the printing machine will use various tints and apply them to the surface of the either laminate or crown based on the map shade, to match surrounding teeth.
Resumen de: WO2024089699A1
Formulations usable for additive manufacturing of a three-dimensional object featuring, in at least a portion thereof, a biological and/or biocompatible material, which utilize minocycline and/or any other compound that features a tetracycline skeleton, as a photoabsorber, are provided, as well as additive manufacturing processes utilizing same and objects obtainable thereby.
Resumen de: WO2024090694A1
The present invention relates to a method for manufacturing a polymer-based microneedle patch designed to maximize skin penetration performance. The polymer-based microneedle patch of the present disclosure can be manufactured to have enhanced penetration power and flexibility as microneedles formed of a polymer with both rigidity and flexibility are combined with an elastic and breathable substrate.
Resumen de: WO2024088536A1
The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.
Resumen de: US2024139380A1
Viscoelastic hydrogel microparticles are used for repair of tissue defects and injuries or filling and occlusion of anatomical structures. These are administered as a microparticle suspension using a catheter, syringe, steerable catheter tip, or comparable technology into the site, where they can be further stabilized by crosslinking or sealing, or through incorporation of a support or encapsulating structure. Materials and methods for solidifying, stabilizing and sealing these materials can be used that are also biocompatible and easily deployed with catheters in the body. The micron sized interstitial spacing provides a scaffold for ingrowth and migration of cells into the gel matrices.
Resumen de: US2024138995A1
The present disclosure discloses an ankle prosthesis containing zirconium-niobium alloy on oxidation layer and a preparation method thereof, the preparation method comprises: using zirconium-niobium alloy powder as a raw material, conducting a 3D printing for one-piece molding to obtain an intermediate products of the talus part and tibial part, and performing Sinter-HIP, cryogenic cooling and surface oxidation to obtain talus part and tibial part. The talus part is connected with the tibial part in a sliding mode; a bone trabeculae is respectively arranged on the lower surface of the talus body and the outer surfaces of the two first fixations, and on the upper surface of the tibial body and the outer surfaces of the two second fixations as well, so as to improve bone ingrowth.
Resumen de: US2024139022A1
A personalized ostomy appliance, including a baseplate, leveraging three-dimensional (“3D”) scanning, computer-aided design modeling, and 3D printing technology, to empower patients to improve quality of life and decrease ostomy complications. In embodiments, the process uses 3D scanning technology to create a raw peristomal mesh. In embodiments, this mesh is filtered using a smoothing and splicing algorithm with patient-specified preference variables. In embodiments, this personalized filtered mesh is then used in a subtractive manufacturing process, including applying a laser cutter or blade press, to alter an ostomy baseplate. The personalized filtered mesh can also used to 3D print a personalized ostomy template that improves fit of the baseplate using a retraction method. This process can be applied to wound care with negative pressure vacuum therapy and fistula management systems wherein a vacuum or pouch baseplate is generated for improved fit and healing.
Resumen de: US2024138958A1
An indirect bonding (IDB) tray that can be positioned over a single tooth of a patient. The IDB tray can include a well to receive an orthodontic bracket therein. The IDB tray can be 3D printed with a rigid photopolymer material and a soft photopolymer material. The soft photopolymer material may be disposed on a gingival portion of the IDB tray such that the soft photopolymer material can be positioned proximate the gums of the patient to improve patient comfort and/or accommodate gum remodeling due to tooth movement. The soft photopolymer material may be disposed around an inner periphery of the well to facilitate bracket insertion and/or release from the well. The IDB tray can include separation indicia indicating where the IDB tray can be sectioned. The IDB tray can include long axis lines to indicate proper orientation of the IDB tray on a patient's one or more teeth.
Resumen de: US2024138717A1
Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
Resumen de: US2024140035A1
A method for making a support element for the human body equipped with a first component or support component, a second component or padding component, wherein at least the second component or padding component is obtained by means of a three-dimensional printing technique; and an apparatus for implementing the method for obtaining the support element and support element thus obtained.
Resumen de: US2024140065A1
Materials and additively manufactured objects including mechanically interlocking elements are provided. In some embodiments, a dental appliance includes an appliance body made at least partially out of a composite material. The composite material can include an interlocking structure having a plurality of interlocking elements. The interlocking structure can have a first mechanical property. The composite material can also include a matrix surrounding at least a portion of the interlocking structure. The matrix can have a second mechanical property different from the first mechanical property.
Resumen de: AU2024202232A1
This document describes systems and method of embedded printing for additive manufacturing. A print material is printed into a support material. The print material and the support material each have a fluid phase and a solid phase. The print material transitions from the fluid phase to the solid phase based on a fluid-fluid interaction with the support material. One or more parameters of the support material can be adjusted to cause a diffusion rate of the print material into the support material during the fluid-fluid interaction to be less than a threshold value. Multiple print materials can be printed into the support material simultaneously.
Resumen de: WO2024092237A1
Described are continuous manufacturing methods using 3D printing or any similar additive manufacturing technology to produce pharmaceutical dosage forms or pharmaceutical delivery devices. Manufacturing methods using hot-melt extrusion to fabricate filaments for fused deposition modeling (FDM) based 3D printing are disclosed. Methods using FDM based 3D printing to fabricate printed products suitable for pharmaceutical delivery purposes are disclosed. The printed products may have various shapes and configurations.
Resumen de: CN117615801A
Provided herein are methods of altering the mechanical and biological properties of polymeric materials. Also provided are compositions comprising a polymeric material having such properties.
Resumen de: CN117500451A
Systems and methods for modeling and planning a dental implant procedure are provided. A method for modeling and planning a dental implant procedure may include receiving a patient profile including a maxilla or mandible model of the patient and kinematic data associated with movement of a jaw of the patient; identifying one or more candidate sites for the dental implant; generating one or more dental implant parameters; determining an indication of a function cone; determining one or more dental implant contact points; generating a constraint graph; selecting an implant model; and generating a modified model.
Resumen de: CN117580543A
The present disclosure provides photopolymerizable components, photocurable resins comprising one or more such monomers, and polymeric materials formed from the photocurable resins. Further provided herein are methods for making and using the compositions in the manufacture of medical devices, such as orthodontic appliances.
Resumen de: EP4360585A2
The present disclosure describes an additive manufactured orthodontic attachment including a body defining a retaining member configured to retain the article in a recess defined by a shell of a transfer tray; a coupling portion configured to engage a tool for insertion of the attachment into the recess of the transfer tray; and a bonding surface configured to bond the attachment to a portion of an outer surface of a tooth of a patient.
Resumen de: WO2022269295A1
Disclosed is a method of forming a microneedle array having a predefined microneedle pattern. The method comprises transforming digital information in a digital input pattern/image into a desired microneedle pattern, such that locations of microneedles in the microneedle pattern correspond to pixels in at least a portion of the digital input pattern or image; and forming a microneedle array having the desired microneedle pattern. Also disclosed is a method of forming a microneedle array having the predefined microneedle pattern using a master microneedle mold. The method comprises masking one or more holes in the master mold at predefined locations to create an array of unmasked holes corresponding to a desired microneedle pattern; and forming a microneedle array having the desired microneedle pattern using the masked master mold.
Resumen de: CA3222290A1
The invention relates to a method (100) for manufacturing anatomical models (1) adapted to simulate organs or parts of organs (2) of a patient. The method comprises the steps of: - obtaining (101) information on the anatomical structure of an organ or part of an organ by processing digital images of said organ; - selecting (102), by means of digital image processing software, elements of the anatomical structure of the organ or part of the organ from the processed images to obtain (103) a three-dimensional computerized model of the anatomical structure of said organ; - representing (104) the three-dimensional computerized model by means of a file (STL) having a valid format usable in a three-dimensional printing process; - manufacturing (105) the representative anatomical model of the organ to be simulated by means of the three-dimensional printing process. Said step of manufacturing comprises the further steps of: - providing (106') a first software library including digital data representative of a plurality of materials usable for manufacturing the anatomical model of the organ to be simulated; - providing (106'') a second software library including digital data representative of a plurality of methods for manufacturing the anatomical model of the organ to be simulated; said manufacturing methods are usable either alternatively or mutually in combination in the three-dimensional printing process; - selecting (107) at least one material from the first software library and a
Resumen de: EP4360539A1
The taste tester (1) comprises the carrier substrate (2), on which at least one test region (3, 3') is formed by the print layer (4) made of a material comprising the taste stimulants for detecting sweet, salty, bitter, sour, and umami taste. Further, the tester is provided with the optical identification member (5) comprising the handling symbol (16) to instruct in the proper use of the tester (1). Further, at least two testers (1) according to the present invention are included in the test kit (7), wherein the data from the application is collected by the system comprising evaluation software module (9) which is linked to the evaluation device (8). The evaluation device (8) is equipped with the camera/camcorder (12) and linked to the database (14) containing information on testers (1). The camera/camcorder (12) is used to take picture/image of the optical identification member (5) of the tester (1) and the evaluation software module (9) of the evaluation device (8) subsequently identifies the tester (1) type by comparison with the data in the database (14).
Resumen de: CN117943129A
本发明属于光催化剂技术领域，公开了地质聚合物/焦硅酸银光催化剂、异质结光催化剂、3D构型光催化剂及制备方法和应用。该地质聚合物/焦硅酸银光催化剂的制备方法，包括以下步骤：将碱与硅溶胶混合得到碱激发液；将碱激发液、铝硅酸盐物料混合，得到地质聚合物前驱体溶胶；将地质聚合物前驱体溶胶与硝酸银混合，原位合成地质聚合物/焦硅酸银光催化剂浆体，经浇筑、干燥和养护得到地质聚合物/焦硅酸银光催化剂。在地质聚合物/焦硅酸银光催化剂的基础上制备了异质结光催化剂、3D构型光催化剂。本发明原位合成光催化剂以及异质结光催化剂，可以通过3D打印的方式成型易回收整体式光催化剂，得到性能更加优异的光催化材料。
Resumen de: CN117942139A
本发明公开了一种3D打印的肺部结节定位辅助装置，属于医疗手术辅助工具技术领域，通过3D打印的前夹板和后夹板夹持，能将整个定位辅助装置稳定的贴合固定在相应的患者身上，提升舒适度以及固定稳定度，避免患者在手术过程的不适感，也为后续穿刺提供稳定的支撑架体，然后通过三个自由度的移动，将结节定位针的位置固定，最终通过导向孔，辅助穿刺，此移动结构，能将结节定位针移动至患者胸部的任一位置上方，辅助进行直线移动穿刺，减少手术医生手持结节定位针时，由于外界因素或者经验因素，导致抖动，减轻患者的痛苦，此装置也降低手术医生的门槛，减少定位手术的时间，为接下来的结节手术提供了良好的术前准备。
Resumen de: US2023103463A1
Modeling material formulations and formulation systems usable in additive manufacturing of a three-dimensional object, featuring, when hardened, a Shore A hardness lower than 10 and/or a Shore 00 hardness lower than 40, are provided. Additive manufacturing processes utilizing these formulations and formulation systems, and three-dimensional objects obtainable thereby, are also provided.
Resumen de: CA3227390A1
The present invention refers to a process to obtain a three-dimensional (3D) biodressing comprising the steps of (a) isolating and culturing mesenchymal cells with human AB serum; (B) performing three-dimensional (3D) bioprinting using a biomaterial such as sodium alginate and cells obtained in step "a"; (c) putting at rest the 3D biodressing obtained after bioprinting; (d) covering the 3D biodressing with a 100 mM calcium chloride solution; (e) washing the 3D biodressing; (f) adding Dulbecco's Modified Eagle Medium (DMEM); and (g) keeping the biodressing in an incubator for up to 15 days. Additionally, the present invention refers to the 3D biodressing obtained comprising, preferably 4% sodium alginate and mesenchymal cells from the umbilical cord (MCUs), which has healing, anti-inflammatory, and analgesic properties. Furthermore, the present invention relates the 3D biodressing to treat patients with chronic wounds and severe burns.
Resumen de: KR20240055911A
본 발명은 계획된 치아의 이동 경로 및 현재 환자의 치아 상태에 따른 3차원 프린터를 이용한 맞춤형 치아 교정 장치의 제작 방법에 관련된 것으로서, 구체적으로는 현재 환자의 치아 상태에 대응되는 치료 계획에 최적화된 교정 장치로서 접착부 및 와이어 고정 구조를 갖는 치아 교정 장치의 식별 정보를 포함하는 모델링 정보를 도출하는 모델링 정보 도출 단계; 치아 교정 장치에 대해 생성된 모델링 정보를 전문 인력 단말에 제공하여 컨펌을 요청하되, 전문 인력 단말에 모델링 정보에 대한 편집 도구를 제공하는 편집 인터페이스를 제공하여, 전문 인력 단말의 편집 입력을 수신함으로써 모델링 정보에 대한 편집을 수행하는 모델링 정보 편집 단계; 모델링 정보 편집 단계에서 모델링 정보에 대한 최종 편집이 완료될 시, 최종 편집된 치아 교정 장치의 모델링 정보로부터 3차원 프린팅 정보를 생성하는 3차원 프린팅 정보 생성 단계; 및, 3차원 프린팅 정보 생성 단계에서 생성된 3차원 프린팅 정보를 3차원 프린터로 전송하여, 치아 교정 장치에 대한 3차원 출력물을 제작하는 제작 단계;를 포함하는 것을 특징으로 한다.
Resumen de: CN117945754A
本发明公开了一种基于光固化增材制造及微波烧结技术制备陶瓷义齿的方法，步骤如下：第一步：将光敏树脂预混液、分散剂、光引发剂和纳米钛酸钡颗粒混合，得到树脂混合物；第二步：向树脂混合物中分多次加入氧化锆，然后至少辊压一次后加入流变助剂，从而得到光固化增材制造膏体，然后真空脱泡；第三步：将光固化增材制造膏体放入增材制造设备内进行光固化成形，得到生坯；第四步：使用流动的清洗溶液清洗生坯，得到清洗后的生坯；第五步：将清洗后的生坯放置在碳化硅管的内腔中并放置在氧化铝板上；第六步：脱脂；第七步：烧结。本发明的目的是提供一种基于光固化增材制造及微波烧结技术、能够在较短周期内绿色节能地制备氧化锆陶瓷义齿的方法。
Resumen de: EP4306235A2
Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser or welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided.
Resumen de: CN117921031A
本申请属于金属材料3D打印技术领域，更具体地，涉及一种提高Ti‑Ta合金组织均匀性和/或力学性能的方法。将TaH合金粉末替换现有工艺Ta粉末，添加至球形CP‑Ti粉末后均匀混合，再用3D打印技术制备微观结构组织均匀且满足人体力学性能需求的生物医用Ti‑Ta合金。在3D打印烧结过程中，TaH中的H原子会发生脱氢反应，在周围合金组织中形成大量晶格缺陷，从而为高熔点的Ta离子和Ti离子相互扩散形成均匀化的微观组织结构提供离子迁移通道，最终获得微观组织均匀的Ti‑Ta合金。
Resumen de: AU2022324120A1
The present disclosure relates to cell cultured adipose tissue. In one embodiment, the cultured adipose tissue is produced by culturing adipose cells in a culture media in vitro, harvesting the adipose cells after a desired amount of adipose cells are produced, and aggregating the harvested adipose cells to provide the cultured adipose tissue. In some embodiments, aggregating the harvested adipose cells comprises mixing the harvested adipose cells with a hydrogel or binder in a three-dimensional (3D) mold. In other embodiments, aggregating the harvested adipose cells comprises cross-linking the harvested adipose cells in a 3D mold. The cultured adipose tissue have a defined 3D shape and a size on the macroscale. In some embodiments, the cultured adipose tissue may be a food product.
Resumen de: CN117918970A
本发明提供一种无托槽隐形矫治器功能模块设计制作的方法，包括步骤：获得数字化牙列模型；确定矫治颌位；添加带有定位标记的底座；3D打印目标模型；制作透明牙套；将透明牙套佩戴在对应的目标模型上；喷涂3D扫描显影剂；粘贴定位标签；扫描目标模型和透明牙套；将透明牙套的数字化模型融合至目标模型；设计功能矫治模块；生产功能矫治模块；将功能矫治模块粘接至透明牙套的外侧面。本发明的一种无托槽隐形矫治器功能模块设计制作的方法，有效解决牙套与功能矫正相结合过程中导致牙套力学性能不佳、佩戴牙套无法正常咬合、牙套变形导致咬合关系改变等问题。该方法制作周期短，且新型牙套具有异物感小、功能性强、美观卫生等优点。
Resumen de: CN220841960U
本实用新型公开了一种海产品包装喷码用表面清洁结构，属于海产品包装喷码领域，为了解决影响喷码墨水的附着力和清晰度，导致喷码质量下降，喷码可能会模糊、晕开或者出现漏印的情况，降低喷码的可读性和辨识度，喷码设备无法正确识别表面，导致喷码位置偏离预定的位置的问题；本申请通过回形紫外线消毒灯进行消毒，吹风机通过吹风软管和吹风直管进行风流传送，风流通过吹风槽吹至海产品包装罐表面，以对其表面的灰尘进行吹扫，以对海产品包装罐表面进行清洁，避免影响喷码墨水的附着力和清晰度，且防止杂质残留。
Resumen de: KR20240054491A
본 발명은 3D 프린팅 기술기반의 의치용 메탈 프레임 제작 방법에 관한 것으로, 상기 방법은, 환자의 구강 인상 모형을 3D 스캐너로 스캔하여 3D 데이터를 생성하는 단계; 상기 3D 데이터를 이용하여, 3D 프레임을 디자인하는 단계; 및 상기 디자인된 3D 프레임을 3D 메탈 프린터를 통해 메탈 프레임을 출력하는 단계를 포함하고, 상기 3D 메탈 프린터는 크롬-코발트(CrCo mediloy) 재료 분말에 레이저를 조사함으로써, 메탈을 10 내지 30 ㎛로 쌓아 출력하는 프린터인 것을 특징으로 한다.
Resumen de: CN220833711U
本申请公开了骨修复支架。所述骨修复支架包括第一微支架，包括若干的第一水凝胶微丝层，第一水凝胶微丝层包括多个平行排列的EV‑TCP水凝胶微丝，相邻第一水凝胶微丝层之间的EV‑TCP水凝胶微丝交错形成菱形孔隙；第二微支架，包括若干的第二水凝胶微丝层，第二水凝胶微丝层包括多个平行排列的EV水凝胶微丝，相邻第二水凝胶微丝层之间的EV水凝胶微丝交错形成矩形孔隙。第一微支架的菱形孔隙的使得细胞展现出成骨倾向，搭配EV‑TCP水凝胶微丝起到良好的骨修复作用，第二微支架的方形孔隙能够促进细胞向软骨分化，搭配EV水凝胶微丝引导细胞再生形成软骨组织。这样利用分层的复合支架结构起到更有效的骨修复效果。
Resumen de: CN117918975A
本发明涉及一种用于牙槽骨三维重建的牙种植的全程导板及制作方法，通过数字化虚拟模型设计操作，牙骨联合支持式种植及植骨导板能用于引导牙种植体窝洞的精准预备及植入；牙骨联合支持式三维定位卡块植骨导板能用于引导骨片按设计的三维植入位置及角度精确植入；取骨导板定位装置能用于对取骨区骨面设置若干个与取骨导板定位固定孔对应的固位孔；取骨导板能用于截取若干个骨片；薄骨片模板能用于引导骨片在受骨区的定位及固定；本发明能针对种植位点存在严重垂直向牙槽嵴骨缺损的情况，辅助医生实现精准、高效、微创、安全的植骨操作，缩短治疗周期，能实现不需口外大量取骨，成功率高，植骨当天种牙当天戴牙。
Resumen de: CA3226174A1
Described are techniques, systems, and methods include those employing pneumatic, pressure assisted, extrusion-based 3D printing and emulsion evaporation, emulsion diffusion, nanoprecipitation, desolvation, gelation, spray-based atomization, etc. for fabricating loaded microparticles or nanoparticles that encapsulate an active pharmaceutical ingredient or live cells into a biocompatible polymer or pharmaceutical excipients. The techniques provide for encapsulation of a variety of substances including proteins, plasmid DNA, lipophilic pharmaceutical compositions, hydrophilic pharmaceutical compositions, live cells, and/or cellular components into polymeric microparticles or nanoparticles. The particles loaded with active pharmaceutical ingredients can be used for the treatment of different diseases or conditions. The particles loaded with live cells can be used for disease treatment, but can also be used for securely storing the live cells in a stable condition for transport and later use in inoculating fermentation systems, for example, to generate recombinant proteins.
Resumen de: CN117923882A
本发明公开了一种基于高固高粘陶瓷膏体制造透明氧化铝托槽的方法，步骤如下：第一步：将硝酸盐溶液与不参与光固反应的有机溶剂混合；第二步：配制光敏树脂预混液；第三步：向第二步中得到的树脂混合物中加入光引发剂，再分若干次加入纯度大于99.99%的α‑氧化铝粉和分散剂，最后加入流变助剂，从而得到光固化增材制造膏体；第四步：将光固化增材制造膏体放入增材制造设备内进行光固化成形，得到生坯；第五步：清洗，在室温风下干燥；第六步：冷等静压：第七步：脱脂；第八步：预烧结；第九步：放入烧结装置中烧结。本发明的目的是提供一种制造周期短、产品性能稳定的基于高固高粘陶瓷膏体制造透明氧化铝托槽的方法。
Resumen de: CN117918973A
本发明提供一种牙列生长调控器和牙列生长调控器的制造方法，牙列生长调控器包括：腭侧基托，用于设置于舌部和硬腭之间，以能够在舌部的吞咽动作中传导舌肌力量；前牙配合组件，包括固定于腭侧基托的前缘的切牙套和在腭侧基托和切牙套之间向下延伸的舌侧翼板，切牙套具有与上前牙的形状相匹配的第一适配槽，舌侧翼板与切牙套之间形成用于在牙齿咬合状态下与下切牙形成限位配合的第二适配槽；磨牙配合组件，包括固定于腭侧基托的侧缘的磨牙套，磨牙套具有与至少一颗磨牙的形状相匹配的第三适配槽。本发明的方案相比于传统功能性矫正器，调控效果更为全面、适应症范围更广、且使用便捷舒适。
Resumen de: CN117920556A
本发明公开了一种面相血脑屏障开启的光致超声换能器及其制备方法，其制备方法包括3D打印声透镜、MOF碳化处理、配置PDMS溶液、制备复合材料、制作换能器五个步骤：首先通过3D打印制作PDMS声聚焦透镜；其次对MOF材料进行碳化处理，以获得中空介孔碳纳米结构；根据PDMS和固化剂质量比10:1配置PDMS溶液；然后将碳化MOF与PDMS溶液均匀混合，真空抽出气泡；最后使用旋涂法制作换能器，将上一步得到的混合溶液滴加在玻璃基板，并用匀胶机均匀旋涂，与声透镜贴合，待其固化。本发明提供的新型光致超声换能器选择高性能吸光材料，可显著提高光声转换效率及超声信号的稳定性，同时与声透镜结合，可实现穿过颅骨的无创超声聚焦。
Resumen de: CN117922015A
本发明属于3D打印技术领域，具体公开了一种生物陶瓷牙模光固化3D打印方法，将由DMD芯片实现的D‑DLP与基于Micro LED的M‑DLP型的图案化的投影光固化成型技术组合，通过轮廓提取识别实现打印生物陶瓷牙模实心部分与空心部分结构的打印要求，进而实现生物陶瓷牙模的牙列与贴合薄面结构的打印，这样在成型的过程中可以实现空心或孔的结构的打印，减少边缘固化，实现大尺寸模型的微结构制备。
Resumen de: CN117921997A
本发明公开了一种弹性体增强水凝胶复合材料直写3D打印制备方法及其在组织工程支架中的应用。首先制备弹性体光敏树脂，原料组分如下：聚氨酯甲基丙烯酸酯20～70份、光固化稀释剂10～50份、无机纳米填料5～40份、光引发剂0.1～5份；将弹性体光敏树脂应用直写3D打印得到弹性体骨架；制备水凝胶光敏树脂，其原料组分如下：聚氨酯甲基丙烯酸酯乳液40～80份、水溶性光固化单体10～60份、光引发剂0.1～5份；将水凝胶光敏树脂浇注到弹性体骨架中，紫外光共固化即得。本发明复合材料既有弹性体骨架赋予的良好力学性能，同时还保留了水凝胶的多孔结构，通过共固化在弹性体和水凝胶界面处形成共价键，实现了强界面结合性能。
Resumen de: MX2022000855A
The invention relates to an arrangement for manufacturing a plurality of orthodontic appliances (1) in parallel, comprising an additive printing machine (2) comprising a build platform (4) and configured for additively manufacturing a plurality of teeth models (9) in parallel, a plurality of plates (6) each configured for teeth model printing by the additive printing machine (2), whereby each plate (6) comprises a unique machine-readable identifier (13) and each plate is detachable and precisely fixed to the build platform (4), and a thermoforming machine (10) configured for thermoforming a thermoformable material (11) over the plurality of teeth models (9) for receiving the plurality of orthodontic appliances (1).
Resumen de: WO2024086096A1
Aspects of the present disclosure include methods for making a polymeric structure having a micro-void space. Methods according to certain embodiments include irradiating a polymerizable composition positioned between a build elevator and a build surface to generate a polymerizable composition having a polymerized region of the polymerizable composition having a micro-void space in contact with the build elevator and a non-polymerized region of the polymerizable composition in contact with the build surface, displacing the build elevator away from the build surface, contacting the generated micro-void space with a non-reactive composition and repeating in a manner sufficient to generate a polymeric structure having a resolved micro-void space. Systems for preparing a polymeric structure according to the subject methods are also described. Polymeric structures having a resolved micro-void space such as where the micro-void space is filled with a non-polymerizable composition are also provided.
Resumen de: WO2024085227A1
Problem The present invention addresses the problem of providing a photopolymerization initiator which is unlikely to be affected by oxygen inhibition, exhibits good photoinitiation properties even in the air, has high sensitivity to long wavelength light rays, and can suppress odors and bleeding out in an obtained cured product. Solution Provided is a photopolymerization initiator which has, in the molecule, one or more benzopheno groups and one or more hetero atom-containing saturated or unsaturated cyclic substituent groups having 5 or more ring-forming atoms. One or more carbon atoms in an aryl group in one or more benzopheno groups is bonded to one or more hetero atom-containing saturated or unsaturated cyclic substituent groups having 5 or more ring-forming atoms via a carboxylic acid ester group or a carboxylic acid amide group.
Resumen de: WO2024086752A1
Systems, methods, and devices for computer-aided design, digital treatment planning, and direct additive manufacturing of dental appliances are provided. In some embodiments, a method includes receiving a treatment plan for a patient's teeth, the treatment plan specifying a target arrangement for the teeth and a plurality of treatment stages to reposition the teeth from an initial arrangement toward the target arrangement. The method can include identifying appliance design parameters for one or more dental appliances to implement at least one treatment stage of the plurality of treatment stages. The appliance design parameters can include one or more manufacturability parameters corresponding to an additive manufacturing process to be used to directly fabricate the one or more dental appliances. The method can further include determining an appliance geometry for the one or more dental appliances using the set of appliance design parameters.
Resumen de: WO2024083825A1
A hollow body and a process for preparing a hollow body having a bottom, an upper end wall and side walls extending between the bottom and the upper end wall, characterized in that the upper end wall and side walls are made of metal, the cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter and the upper end wall comprises at least one opening. The hollow body are suitable for encapsulating small amounts of liquid, or of very small micro-electromechanical system, may be used for the controlled release of pharmaceutical components.
Resumen de: WO2024083859A1
The invention relates to an applicator device and a method for operating an applicator device, which comprises a measuring system for detecting a surface of an object to be coated and which uses a multi-axis movement guide to apply a plurality of liquids for printing the object to be coated in a multi-part printing system, such that surfaces or surface regions are coated with the liquid(s) in such a way that the physical properties of the dental prosthesis change.
Resumen de: WO2024084040A1
The disclosure relates to an aqueous bioink solution for use in light-based bioprinting applications, comprising: (a) 0.5-95 wt % water-soluble prepolymer; (b) 0.001-5 wt % biocompatible metal acylphosphinate photoinitiator; (c) 0.001-10 wt % biocompatible light absorber; and (d) 5 to 99.5 wt % solvent. The disclosure further relates to a method of using the aqueous bioink solution including living cells and a method of using the aqueous bioink solution without living cells (acellularly).
Resumen de: WO2024083145A1
Provided herein are drug dosage forms designed to provide a desired retention in an individual based on geometric differences between a pre-administration and post-administration state of the dosage form. In certain aspects, provided are oral drug dosage forms comprising a swellable and expandable material configured, upon swelling or expanding, to drive expansion of the overall size of the oral drug dosage forms such that the oral drug dosage forms are retained in the stomach for a desired period of time. In certain other aspects, provided is directed to components useful for the oral drug dosage forms taught herein. In certain other aspects, provided is directed to methods of designing, methods of making, such as involving three-dimensional (3D) printing, injection molding, ultrasonic welding, or any combination thereof, commercial batches, and methods of delivering a drug to an individual comprising administering an oral drug dosage form taught herein.
Resumen de: WO2024082029A1
A melt electrowritten soft tissue scaffold, comprising: a first region having one or more sets of fibres and a second region having one or more sets of fibres; and an interface region joining the first region and the second region, the interface region being electrowritten along with the first and second regions in a continuous printing path, such that fibres in the interface region each join between a respective pair of fibres in the first and second regions.
Resumen de: KR20240053692A
본 발명은 뼈 세포외 기질과 유사한 합성 고분자/천연 고분자 하이드로겔 기반 3D 스캐폴드에 관한 것으로, 구체적으로 기존 합성 고분자 스캐폴드에 매트리솜이 포함된 천연 고분자 하이드로겔을 충진시킴으로써 기계적 물성은 유지되면서 주변 골 조직 세포의 부착, 증식 및 골 분화가 향상되어 보다 빠른 골 재생 효과를 나타내어 줄기세포 배양 및 골 이식재 또는 대체재로 사용 가능하다.
Resumen de: WO2024086178A1
This invention provides an expandable endotracheal tube (ETT) and method for use of the same, including a frame having a plurality of hoops joined by longitudinal ribs, the hoops formed into a compressed configuration with torsional spring force imparted thereby, a collapsible shell covering the frame that defines a sealed tube between a proximal end and a distal end, and a retaining structure that maintains the hoops in the compressed configuration with the frame and the shell defining a compressed outer diameter. The retaining structure is selectively releasable to cause to the frame and the shell to expand to an expanded diameter that is greater than the compressed diameter, and/or can include a member that passes through a plurality of holes located along overlapping circumferential positions of the frame and the shell folded therearound. The retaining structure can comprise a string under tension.
Resumen de: WO2024086253A1
Liquid compositions containing at least one S-nitrosothiol (RSNO), such as S-nitroso-N- acetylpenicillamine (SNAP) and S -nitrosoglutathione (GSNO), and at least one alkanediol or alkanediol oligomer/polymer are provided. To modulate the rate of release of NO, metal ion chelators may be added to reduce RSNO reactivity or chemical catalysts of RSNO decomposition may be added to increase RSNO reactivity. To suppress formation of undesirable nitrogen oxide species such as NO2, bases or reducing agents may be added. Methods of delivering nitric oxide to a subject and treating respiratory diseases by administering the liquid compositions are also provided.
Resumen de: WO2024086372A1
A system and method of adjusting a dental appliance by modifying a corresponding digital dental appliance model. The system includes an additive manufacturing system (e.g., a 3D printer system) and a controller running software. The system is designed to (i) 3D print a dental appliance using an initial digital dental appliance model, (ii) determine any portions of the printed dental appliance that may require modification, (iii) automatically adjust the appliance's digital model by performing pixel offsetting to implement a modification, and (iv) reprint the appliance using the modified digital model.
Resumen de: EP4356877A2
A lattice or solid structure for a medical device, such as a liner (100) in prosthetic use, includes a first layer (122) of first filaments (140) discretely formed from at least one medical-grade silicone material. The first filaments (140) are arranged in a predetermined pattern and may be directly adjacent to one another or spaced apart. Additional layers of filaments (142) may be provided adjacent to the first layer (122), and chemically bonded thereto to form an integrated structure that is without interruption or with interstices therebetween.
Resumen de: CN117203709A
The invention relates to a method of personalized pharmacy. More specifically, the present invention relates to a method for producing a pharmaceutical dosage form, which is produced by 3D and/or 2D printing, whereby a variety of parameters associated with dosage form administration can be varied according to the analysis of patient and disease-specific data, and a variety of parameters associated with dosage form administration can be adjusted during treatment of a patient. Therefore, the treatment quality of the patient can be improved in the future, and the safety of the patient can be remarkably improved.
Resumen de: EP4357296A1
A hollow body and a process for preparing a hollow body having a bottom, an upper end wall and side walls extending between the bottom and the upper end wall, characterized in that the upper end wall and side walls are made of metal, the cavity within the hollow body has a volume in the range between 1 picoliter to 1,000 picoliter and the upper end wall comprises at least one opening. The hollow body are suitable for encapsulating small amounts of liquid. or of very small micro-electromechanical system, may be used for the controlled release of pharmaceutical components.
Resumen de: AU2021450888A1
Oral appliance delivery trays for use in maintaining or improving oral health, particularly the sub-gingival region, are provided. Methods of manufacturing individualized oral appliance delivery trays are provided. Pre-fabricated oral appliance trays comprising a compound pre-disposed therein are provided. The compositions and methods may be used to maintain or improve oral, periodontal and systemic health or to prevent or slow oral, periodontal or systemic health issues related to the oral cavity.
Resumen de: AU2022295672A1
Disclosed are Self-Gelling materials and structures or materials or structures having one or more self-gelling components that overcome existing gel limitations due to hydrogel localization for medical applications by providing, for example, 1) microstructurally, or physically, anchored characteristics to help localize the gel, and the overall printed, or otherwise formed structure, giving structural form to the gel that allows the gel to be localized within the body, and even sutured in place, and mitigates gel migration and extends its residence time; 2) to provide an underlying 3D printed structure to help contain and support the gel after implantation; and more. Self-Gelling 3D printed structures may be further processed via milling to yield deconstructed scaffold micro-granules, with the composition and nano- / micro- structure of the original larger structure. Deconstructed scaffold micro-granules may be hydrated to form a micro-granule embedded gel network that can be injected, giving form to injectable gels.
Resumen de: WO2024051899A1
The invention relates to a device for producing a moulded part of a dental splint comprising a base element, a retaining plate and at least one receiving element, the at least one receiving element being arranged releasably on an upper side of the retaining plate, the at least one receiving element being designed to receive a tooth template, and the at least one receiving element being fixable on the retaining plate in a plurality of positions and/or orientations. The invention further relates to an apparatus for producing a dental splint by means of such a device, and to a method for producing a dental splint, in particular using the apparatus.
Resumen de: US2024122715A1
The present disclosure relates to a 3D-printed semi-finished part for manufacturing at least one medical implant or medical instrument, the semi-finished part including:at least one functional feature provided at a predefined location of the semi-finished part.
Resumen de: EP4357049A2
An electrosurgical instrument comprising an end effector is disclosed. The end effector comprises a first jaw and a second jaw. At least one of the first jaw and the second jaw is movable to transition the end effector from an open configuration to a closed configuration to grasp tissue therebetween. The second jaw comprises linear portions cooperating to form an angular profile and a treatment surface comprising segments extending along the angular profile. The segments comprise different geometries and different conductivities. The segments are configured to produce variable energy densities along the treatment surface.
Resumen de: KR20240052239A
본 발명은 임플란트 크라운 제조 방법에 관한 것으로, 본 발명의 일실시예는 (A) 3D 프린팅을 이용하여 설정된 광투과도를 갖는 임플란트 크라운 제조용 몰드를 형성하는 단계; (B) 상기 임플란트 크라운 제조용 몰드 내에 광경화 세라믹 슬러리를 주입하는 단계; (C) 상기 광경화 세라믹 슬러리를 경화시켜 임플란트 크라운을 형성하는 단계; (D) 상기 임플란트 크라운 제조용 몰드를 제거하는 단계; 및 (E) 상기 임플란트 크라운을 열처리하는 단계를 포함하는, 임플란트 크라운 제조 방법을 제공한다.
Resumen de: USRE49930E
Disclosed is a concept for computer-assisted procedures of surgery and diagnosis that target rigid, non-deformable anatomical parts such as bone, tissue, or teeth. The disclosure describes attaching small visual markers to instruments and anatomy of interest (e.g. bone surface), with each marker having a printed known pattern for detection and unique identification in images acquired by a free-moving camera, and a geometry that enables estimating its rotation and translation with respect to the camera using solely image processing techniques.
Resumen de: US2023144308A1
A system for manufacturing and using an implant for correcting a defect of a bone structure is described. In some examples, the implant includes a first surface comprising a shape configured to interface with a surface of the bone structure. In some examples, the implant includes a second surface opposite the first surface and substantially conformal to the shape of the first surface, the second surface comprising three or more point features on the second surface, wherein the three or more point features comprise a first point feature, a second point feature, and a third point feature that form nodes of a triangle, wherein each of the three or more point features are recessed below the second surface.
Resumen de: WO2022238441A1
The present invention relates to polymeric compounds of glucuronic acid having phenolic hydroxyl moieties (herein after designated by PGU-Ph) and more particularly to a method of hydrogelation of such compounds. The present invention also relates to the use of the hydrogel structures (particles, films or 3D-strucutres) obtained by this method, notably as three-dimensional cell culture material to support biological molecules used as active ingredients, cell colonisation or for tissue regeneration.
Resumen de: WO2024080445A1
Provided are a preparation method of an edible cell cultured fish that can implement an actual fish muscle shape and mouthfeel, and a cell cultured fish prepared thereby. The preparation method of a cell cultured fish comprising a fish muscle-mimicking muscle shape by using 3D bioprinting technology comprises the steps of: mixing cells for cell cultured fish and edible bioink; forming a layered structure by printing the ink for cell printing in a fish muscle-mimicking pattern; adding a crosslinking agent to the layered structure; and culturing the cross-linking agent-added layered structure into fish muscle tissue.
Resumen de: EP4269109A2
The present invention relates to a suspension comprising 50-95% by weight of the total suspension (w/w) of at least one ceramic material and at least 5% by weight of the total suspension of one or more fatty acids or derivatives thereof. In addition, the invention relates to uses of such suspension in extrusion processes.
Nº publicación: PL442583A1 22/04/2024
Solicitante:
UNIV RZESZOWSKI [PL]
POLITECHNIKA RZESZOWSKA IM IGNACEGO LUKASIEWICZA [PL]
UNIWERSYTET RZESZOWSKI,
POLITECHNIKA RZESZOWSKA IM. IGNACEGO \u0141UKASIEWICZA
Resumen de: PL442583A1
Metoda formowania implantów oczodołu, ma zastosowanie przeznaczona w chirurgii rekonstrukcyjnej u pacjentów z jednostronnym uszkodzeniem części twarzowej. Metoda polega na tym, że wykonuje się badanie tomograficzne czaszki pacjenta, na tej podstawie, wykorzystując komputerowe techniki modelowania CAD/CAE tworzy się cyfrowy, symetryczny względem pionowej płaszczyzny symetrii czaszki obraz nieuszkodzonej części kości twarzoczaszki, a następnie, na tej podstawie, na drukarce 3D drukuje się dedykowaną do indywidualnego przypadku, formę kości oczodołu złożoną z matrycy i, korzystnie, stempla, przy czym powierzchnię matrycy obniża się w stosunku do budowy anatomicznej o, w przybliżeniu, grubość płytki, z której, w kolejnej operacji, w odpowiedniej dla zastosowanego na implant tworzywa temperaturze, kształtuje się manualnie implant. Korzystnie, wstępne ukształtowanie implantu dokonuje się dociskając stempel do matrycy z nałożoną płytką do modelowania implantu. Na implanty stosuje się materiały polimerowe — termoplastyczne i chemoutwardzalne oraz metale.
BOPI
Sede Electrónica
