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一种用于治疗心肌梗死的3D生物打印心外膜贴片及其制备方法和应用

Resumen de: CN120900005A

本发明公开了一种用于治疗心肌梗死的3D生物打印心外膜贴片及其制备方法和应用。所述的3D生物打印心外膜贴片是由含有负载重组人血管内皮生长因子(rhVEGF165)的壳聚糖纳米颗粒以及人骨髓间充质干细胞(hMSCs)的甲基丙烯酰明胶(GelMA)生物墨水通过3D生物打印出的具有特定结构的心外膜贴片。通过对所制备的贴片进行形态观察、力学性能检测、溶胀性能检测及降解性能检测，验证了其良好的物理化学特性。体外释放试验表明，该贴片可以持续稳定地释放rhVEGF165，促进细胞增殖和血管生成。体内实验证实其能够有效促进心脏功能恢复，改善心肌重构，并显著增加缺血区域的血管新生。本发明的提出为心肌梗死后的修复提供了新的技术手段。此方法不仅展示了优异的临床转化潜力，也为心血管疾病治疗开辟了新路径。

一种自产氧生物3D打印间充质干细胞肝脏类器官支架的构建方法

Resumen de: CN120899998A

本发明公开了一种自产氧生物3D打印间充质干细胞肝脏类器官支架的构建方法，其包括以下步骤：制备CaO2@ZIF‑8@SL纳米颗粒；将CaO2@ZIF‑8@SL纳米颗粒加入甲基丙烯酰化明胶和甲基丙烯酰化透明质酸的混合溶液中，以获得所述自产氧生物3D打印间充质干细胞肝脏类器官支架。本发明的方法制得的自产氧生物3D打印间充质干细胞肝脏类器官支架具有在较长时间内释放氧气的稳定性，以及良好的ROS清除能力，且无细胞毒性，可用于构建人肝脏类器官模型。

巯基化的重组细菌胶原样蛋白

Resumen de: WO2024188850A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one thiol group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and optionally at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.

一种3D生物打印骨髓间充质干细胞血管外支架及其制备方法和应用

Resumen de: CN120900008A

本发明公开了一种3D生物打印骨髓间充质干细胞血管外支架及其制备方法和应用。所述的3D生物打印骨髓间充质干细胞血管外支架是由含有SIRT3过表达的骨髓间充质干细胞(BMSCs)的生物墨水通过3D生物打印获得的，所述的生物墨水中含有甲基丙烯酰化透明质酸(HAMA)以及甲基丙烯酰化明胶(GelMA)。通过建立大鼠动‑静脉移植模型评估其对提高静脉桥远期通畅率的作用。实验结果表明，所述的3D生物打印骨髓间充质干细胞血管外支架不仅具有良好的结构稳定性和生物相容性，还能显著提高静脉桥远期通畅率，促进受损组织修复，增强血管功能恢复能力，在改善心血管疾病治疗效果方面具有潜在的应用前景。

一种皮肤的挤出/喷墨复合打印装置

Resumen de: CN223520223U

本实用新型公开了一种皮肤的挤出/喷墨复合打印装置，属于生物组织打印技术领域，包括计算机、三维运动系统、墨盒、喷墨打印头、挤出打印头、温控基板、气泵和压力控制器；墨盒安装在所述喷墨打印头上，喷墨打印头和挤出打印头安装在所述三维运动系统上；压力控制器安装在所述气泵上；压力控制器与墨盒和挤出打印头气连接；计算机分别与所述三维运动系统、喷墨打印头和压力控制器电连接；计算机用于控制所述三维运动系统运动，还用于控制喷墨打印头的喷墨和压力控制器输出气压值。本实用新型提供了一种制造成本低、效率高的个性化皮肤打印装置。

一种3D打印的清洗固化消毒一体机

Resumen de: CN223520234U

本实用新型公开了一种3D打印的清洗固化消毒一体机，其包括底座，其特征在于：还包括罩设于底座上的外壳、置于外壳内且位于底座上的呈透明的清洗容器、置于外壳内的照射装置，所述照射装置包括至少一组位于清洗容器上开口上方和至少一组位于清洗容器侧边的照射组件，所述照射组件包括紫外灯珠；所述外壳内设置有扰动装置，所述扰动装置包括磁力电机、连接于磁力电机输出轴的磁性片、置于清洗容器内的磁珠，所述磁珠与磁性片磁性相吸。本申请具有对3D打印模型进行更好的清洗、固化和消毒的效果。

一种手术膜及制备工艺

Resumen de: CN120902327A

本发明涉及医疗用品制备技术领域，尤其涉及一种手术膜及制备工艺，在具体使用时，首先通过选用聚氨酯基膜并进行等离子处理；在处理后的聚氨酯基膜表面喷涂含光引发剂的纳米SiO2分散液，随后采用紫外图案化照射，形成微凸起结构得到基材层；将胶体液通过数字微镜装置投射温度梯度掩模，使胶体液在基材层上发生区域性热聚合，形成具有粘性梯度的智能胶层；采用气溶胶喷射打印技术，将超吸水纤维与聚乙烯醇‑硼砂动态交联水凝胶共沉积，形成引流层即可，以此方式解决了现有技术中的手术膜制备方式所制备的手术膜粘附不灵活、表面结构性能差、且制备工艺难精确控制的技术问题。

利用插入路径的牙齿矫正装置的制造方法

Resumen de: WO2024228520A1

The present invention relates to a program for designing an orthodontic device, and comprises the steps of: (S01) displaying, on a screen, an insertion path for determining the insertion direction of the orthodontic device; (S02) designating a tooth to be set as an insertion path; (S03) setting the insertion path in an arbitrary direction with respect to the designated tooth; (S04) displaying, on a screen, undercuts of each tooth generated by the set insertion path; (S05) calculating and storing depth values of the undercuts for each tooth according to the insertion path; and (S06) calculating and storing the total value of the volume of the undercuts for each tooth according to the insertion path.

打印装置和蒸汽灭菌器

Resumen de: CN223520491U

本实用新型涉及带有打印机的蒸汽灭菌设备领域，具体为一种打印装置和蒸汽灭菌器，打印装置包括壳体、打印机和盖板。其中，壳体一侧具有开口部；打印机安装于壳体内部，打印机朝向开口部一侧设有打印口，打印口供打印机中的纸卷展开并经其伸出；盖板表面设有腰型孔，盖板以腰型孔对应于打印口的方式，可开启地覆盖于开口部，盖板的设置腰型孔的部位与打印口贴合。通过将腰型孔和打印口贴合设置，可避免打印纸进入打印机与盖板之间的间隙，进而减少工作人员使用蒸汽灭菌器的打印机之前的准备步骤，提高打印机的工作效率，并节约了打印纸的用量。

由Ti/Nb/Ta合金粉末生产物体的方法

Resumen de: AU2024242662A1

The present invention relates to a method for producing a body from a Ti/Nb/Ta alloyed powder, a body produced according to this method, and the use of a Ti/Nb/Ta alloyed powder for producing a body by laser powder bed fusion.

ANTIBACTERIAL DENTAL PHOTOCURING 3D PRINTING RESIN COMPOSITION, 3D PRINTING ARTICLE OF MANUFACTURE, AND USE THEREOF

Resumen de: WO2025227560A1

Disclosed are an antibacterial dental photocuring 3D printing resin composition, a 3D printing article of manufacture, and use thereof. The antibacterial dental photocuring 3D printing resin composition comprises a modified polyurethane acrylate oligomer, a modified epoxy acrylate oligomer, and PLA microspheres. The modified polyurethane acrylate oligomer comprises an antibacterial group introduced into the original polyurethane resin, enabling chemical grafting instead of physical mixing. In addition, the modified epoxy acrylate oligomer comprises an introduced PLA group, further improving the strength and wear resistance of dental resin and ensuring environmental friendliness and safety. The modified oligomers and the PLA microspheres added to the composition work synergistically to enable the composition to have excellent, stable, and lasting antibacterial performance.

3D PRINTER SLURRY COMPOSITION USING SI3N4

Resumen de: WO2025230026A1

Disclosed is a 3D printer slurry composition using Si3N4, which is based on the non-oxide ceramic material of Si3N4, is biocompatible, has excellent bacterial resistance, and has improved flexural strength, fracture toughness and the like. The disclosed 3D printer slurry composition using Si3N4 comprises 60 to 66 wt% of ceramic powder, 30 to 36 wt% of a photocurable binder, and 3 to 5 wt% of a dispersant, wherein the ceramic powder can comprise Si3N4 and a sintering additive.

PLATFORM AND METHOD FOR THE MANAGEMENT AND MANUFACTURE OF RETAINERS

Resumen de: WO2025231428A1

A digital platform for managing and manufacturing retainers is disclosed. The digital platform may be accessed by an orthodontist and a patient and may be communicatively coupled with a manufacturer system. The digital platform may create a patient profile associated with a patient, and the patient profile may include a scan of the patient's teeth. The digital platform may provide the scan of the patient's teeth to the manufacturer system so that the manufacturer system can create the retainer and send it to the patient.

A DEVICE FOR MODULATING GROWTH PLATE ACTIVITY AND/OR FOR ORTHODONTIC APPLICATIONS

Resumen de: WO2025229167A1

A device for modulating growth plate activity and/or for orthodontic applications, the device comprising: a first wire-like element (1) a first, preferably plate-like, fixation element (3), configured to be fixated on a bone or a tooth; wherein the first fixation element (3) comprises at least one receiving element (5), wherein the receiving element (5) is configured for receiving a fastening means, each receiving element preferably in the form of a through-hole in the fixation element (3), wherein the first fixation element (3) comprises a first guiding element (7), configured for guiding the first wire-like element (1), and wherein the first fixation element (3) comprises a first deflecting element (11) configured to deflect a portion of the first wire-like element (1); and wherein a first portion, preferably its first end-portion (14), of the first wire-like element (1) is configured to be fixated on a bone or a tooth; or wherein the first portion, preferably its first end-portion (14), of the first wire-like element (1) is fixated on a second fixation element (4), wherein the second fixation element (4) comprises at least one receiving element (6) configured for receiving a fastening means.

POLYMER-PHOSPHATE-BASED COMPOSITION FOR 3D PRINTED IMPLANTS

Resumen de: WO2025228468A1

The invention provides a composition for low-temperature 3D printing of tissue implants, which contains: - calcium phosphate powder, - chitosan particles, - aqueous solution of block copolymer (D,L-polylactide-co-polyglycolide)-b-poly(ethyleneglycol)-b- (D,L-polylactide-co-polyglycolide) (PLGA-PEG-PLGA). A kit and a method for preparing the composition are provided, as well as a method for printing tissue implants using the kit.

CONTINUOUS SYNTHESIS OF OCTACALCIUM PHOSPHATE

Resumen de: WO2025229626A1

The present innovation relates to biomaterials, particularly, to the synthesis method of octacalcium phosphate. The method can be applied in the commercial manufacturing of biomaterials for bone tissue regeneration or dental restoration, such as bioinks for 3D printing, calcium phosphate cements, bioceramics, composites and drug delivery systems. The current invention developed a rapid, instant, controllable as well as reproducible procedure for the continuous synthesis of octacalcium phosphate.

ORTHODONTIC APPLIANCES AND METHODS OF MANUFACTURING

Resumen de: WO2025229219A1

Orthodontic appliances are disclosed, comprising an integrally formed shell including a first shell part comprising one or more first cavities adapted to receive the first teeth of the patient, a second shell part comprising one or more second cavities adapted to receive the second teeth of the patient, and a modified active shell part connecting the first shell part and the second shell part, and wherein the modified active shell part comprises one or more active elements configured to apply forces to the first and/or the second shell part. The disclosure further relates to methods for manufacturing an orthodontic appliance, to computer-implemented methods for generating an input file for a 3D printer and to kits comprising series of consecutive shells.

Therapeutic Oral Device

Resumen de: US2025339308A1

The present disclosure provides generally for a therapeutic oral device for assessing one or more health aspects of a user and/or alleviating one or more health conditions of a user, and associated methods for using the device. The device may comprise a hard palate portion, a mouth guard portion, and a tongue retainer portion. The hard palate portion may comprise one or more materials. The hard palate portion may also comprise a composite of materials. The mouth guard portion may comprise one or more components that provide stability and maintain the position of the therapeutic oral device within the mouth of a user. The tongue retainer portion may comprise an airway and a predetermined length. In some embodiments, the therapeutic oral appliance may comprise a mandibular mouth guard portion.

POROUS-BASED TALUS RECONSTRUCTION PROSTHESIS AND ASSOCIATED METHOD

Resumen de: US2025339282A1

This invention is designed for orthopedic applications. It features a proximal surface for tibial articulation, a distal surface for calcaneal engagement, and a central canal for a fixation nail. Offered in spherical, ellipsoidal, and anatomically contoured shapes, the prosthesis includes a gyroid lattice structure for improved osseointegration. A method for its creation involves 3D modeling from CT scans, shape design, lattice definition, and 3D printing, focusing on dimensions and density variations to ensure proper fit and functionality while addressing anatomical needs.

INTEGRATED VISUALIZATION, SUCTION, AND IRRIGATION SYSTEM FOR ENT PROCEDURES

Resumen de: US2025339015A1

A method of forming an endoscopic device includes forming, by a three-dimensional (3D) printer, a first tube of an endoscopic sleeve, where the first tube is sized to receive an imaging device. The method also includes forming, by the 3D printer, a second tube of the endoscopic sleeve such that at least a portion of the second tube is mounted to the first tube, where the second tube is sized to connect to an irrigation system. The method further includes forming, by the 3D printer, a third tube of the endoscopic sleeve such that at least a portion of the third tube is mounted to one or more of the first tube and the second tube, where the third tube is sized to connect to a vacuum system.

HINGE MECHANISM FOR A KNEE ORTHOSIS, PROCEDURE FOR FITTING A HINGE MECHANISM, AND A KNEE ORTHOSIS

Resumen de: EP4643829A1

The invention is related to the technical field of orthopedic devices, in particular knee orthoses for supporting a knee joint, and more specifically of an orthopedic device with a hinge, wherein the movement of the device can be limited by means of the hinge and where the hinge of the device is formed via 3D printing so that a knee orthosis can be made to measure for the patient and where a minimum of different parts is required for the assembly of the knee brace. The invention also includes a method for installing such hinge mechanisms and a knee orthosis provided with such hinge mechanisms.

DENTAL IMPLANTS WITH CORONAL FEATURES AND SYSTEMS, DEVICES, AND METHODS FOR DESIGNING AND MANUFACTURING SAME

Resumen de: WO2024145635A2

Root-analog dental implants include one or more coronal grooves that are sized, shaped, and/or configured to correspond to a size, shape, and/or position of a bone crest for an extracted tooth a root-analog dental implant is designed and manufactured to replace. The coronal grooves may be configured to engage with bone of an alveolar socket to enhance engagement between the root-analog dental implant and the alveolar socket particularly for the time period following seating the root-analog dental implant within the socket site and prior to osseointegration of the root-analog dental implant with the alveolar socket. This promotes stability of the root-analog dental implant within the socket site immediately following insertion and thereafter, which may decrease movement of the root-analog dental implant within the socket site, decrease a likelihood of foreign material such as bacteria or food entering the socket site, and/or reduce a risk of implant failure and jawbone injury.

3D PRINTING COMPOSITION FOR BIOMATERIALS

Resumen de: EP4644125A2

A 3D printing resin composition for a biomaterial and method for 3D printing the composition, wherein the composition comprises:(i) a pre-polymer comprising a polymeric unit of the general formula (-A-B-)_n, wherein A represents a substituted or un-substituted ester, B represents a substituted or un-substituted acid ester comprising at least two acid ester functionalities, and n represents an integer greater than 1,(ii) at least one photo-initiator, and(iii) at least one light blocker.

MATERIAL AND METHOD FOR PRODUCING CELL RECEIVING SCAFFOLD

Resumen de: EP4628303A2

A printable composition for the manufacture of cell-receiving scaffolds comprising about 0.3 wt% to about 3.0 wt% of one or more collagens; about 5.0 wt% to about 40.0 wt% of one or more monomers; about 0.5 wt% to about 2.0 wt% of a photo initiator; and 0 wt% to about 75 wt% of a vehicle comprising a protic solvent, by weight of the printable composition; wherein the printable composition has a resolution of about 100 microns or less when printed, a photo speed (Dp/Ec) of about 0.1-5 mm (Dp) and about 10-100 mJ/cm² (Ec) when printed, and a green strength of at least about 5 kPa after drying. The present technology further includes methods of manufacturing a three-dimensional cell-receiving scaffold using the printable composition.

DEVICES AND METHODS FOR POST-PROCESSING ADDITIVE-MANUFACTURED WORKPIECES

Resumen de: WO2024141861A1

Post-processing devices for post-processing additive-manufactured workpieces and methods thereof are described. Sequential cleaning and post-curing under vacuum may be accomplished within a single device. The post-processing device (100, 200A, 400) comprises: a chamber (102, 202, 402) comprising an inlet (104, 204, 404) configured to be in communication with a vacuum source, and an electrical outlet configured to be in communication with a power source; a spinning platform (108, 208, 308, 408) for retaining a plurality of workpieces (222), a rotating drive apparatus (118, 218, 418) for rotating the spinning platform; a collection vat (116, 216, 416) surrounding the spinning platform; and one or more post-curing light source (120, 220, 420); wherein the spinning platform, the rotating drive apparatus, and the collection vat, are housed within the chamber.

FERROMAGNETIC SKIRT FOR A MEDICAL DEVICE

Resumen de: WO2024163373A1

An implantable medical device includes a wire frame, a cover, and a sensor. The wire frame is formed of struts and openings. The cover connects to the struts of the wire frame. The cover is fashioned from a fabric including a PET fabric made of PET yarn and a ferromagnetic material combined with the PET fabric. The PET yarn is made from a plurality of PET fibers. The sensor is positioned on the cover and connected to the wire frame. The cover shields the sensor from detuning effects of the wire frame.

微小空隙空間を有するポリマー構造並びにそれを作製するためのシステム及び方法

Resumen de: CN120225338A

Aspects of the present disclosure include methods for making polymer structures having microvoid spaces. A method according to certain embodiments includes irradiating a polymerizable composition positioned between a build lift table and a build surface to produce such polymerizable composition, the polymerizable composition has: a polymerized region of the polymerizable composition having a microvoid space in contact with a build lift table and a non-polymerized region of the polymerizable composition in contact with a build surface; removing the build lift from the build surface; contacting the generated microvoid space with a non-reactive composition; and repeating in a manner sufficient to create a polymer structure having a clearly discernible microvoid space. Systems for preparing polymer structures according to the subject methods are also described. Also provided are polymer structures having clearly discernible microvoid spaces, such as where the microvoid spaces are filled with a non-polymerizable composition.

ORTHODONTIC APPLIANCES AND METHODS OF MANUFACTURING

Resumen de: EP4643810A1

Orthodontic appliances are disclosed, comprising an integrally formed shell including a first shell part comprising one or more first cavities adapted to receive the first teeth of the patient, a second shell part comprising one or more second cavities adapted to receive the second teeth of the patient, and a modified active shell part connecting the first shell part and the second shell part, and wherein the modified active shell part comprises one or more active elements configured to apply forces to the first and/or the second shell part. The disclosure further relates to methods for manufacturing an orthodontic appliance, to computer-implemented methods for generating an input file for a 3D printer and to kits comprising series of consecutive shells.

LIQUID WITH PATTERN AND PRODUCTION METHOD FOR SAME

Resumen de: EP4643651A1

The present invention aims to provide a pattern-containing liquid that contains, in a liquid matrix, a pattern that can provide color, taste, or tactile sensations such as mouthfeel and texture, and that has good stability, as well as a method for producing a pattern-containing liquid capable of stably forming the above pattern in a liquid matrix. The present invention relates to, for example, a pattern-containing liquid containing a pattern formed from at least one of a microparticulate or a colorant in a liquid matrix, the liquid matrix being a pseudoplastic fluid and contained in a container.

HYDROGEL COMPOSITION FOR 3D PRINTING, AND 3D PRINTING HYDROGEL PREPARED THEREFROM

Resumen de: EP4644440A1

The present invention relates to a hydrogel composition for 3D printing, and a 3D printing hydrogel formed using the same, hydrogel composition comprising an acrylamide-based compound, a hydrophilic thickener, an alkali compound and a solvent.

使用3D打印聚电解质结构作为反向牺牲模板创建用于再生医学的3D分级通道支架

Resumen de: WO2024151882A1

What is presented herein is a robust sacrificial strategy to create hierarchical and perfusable microchannel networks within versatile scaffolds via the combination of embedded 3D printing (EB3DP), tunable poly electrolyte complexes (PEC), and casting methods. The sacrificial templates of PEC filaments (diameter from 100 to 500 pm) with arbitrary 3D configurations can be fabricated by EB3DP and then incorporated into various castable matrices (e.g., hydrogels, organic solutions, meltable polymers, etc.). Rapid dissolution of PEC templates within a 2.00 M potassium bromide aqueous solution leads to the high-fidelity7 formation of interconnected channels for free mass exchange. Continuous cell proliferation and ECM deposition is seen as a result. Subcutaneous implantation of channeled silk fibroin (SF) scaffolds with a porosity of 76% could lead to tissue ingrowth as high as 53%. Both histological and immunofluorescence analyses demonstrate that such channeled scaffolds promoted cellularization, vascularization, and host integration along with immunoregulation.

一种制造正畸装置的系统和方法

Resumen de: WO2024199274A1

The present disclosure provides systems and methods for orthodontic appliance production. The methods may include determining a baseline thickness of an orthodontic appliance for orthodontically treating teeth of a target subject. The methods may include, for each local point on the teeth of the target subject, determining a movement path of the local point from an initial location of the local point to a target location of the local point. The methods may also include, for each local point on the teeth of the target subject, determining, based on the movement path and the baseline thickness, a target thickness of the orthodontic appliance corresponding to the local point. The methods may further include directing a three-dimensional (3D) printer to integrally produce, based on the target thickness of the orthodontic appliance at each local point, the orthodontic appliance.

用于牙齿矫正的透明矫治器及附件的设计方法

Resumen de: WO2024232571A1

A design method for a transparent orthodontic device and an attachment for orthodontics according to the present invention, which is devised in order to solve the technical problem as described above, is a method for designing an orthodontic device by using a computer. As a means for solving the technical problem, the method comprises: a step (S01) of designing a shape of an attachment attached to a surface of a tooth model; a step (S02) of designing an inner surface shape of a transparent orthodontic device to correspond to the shape of the attachment designed in step S01; and a step (S03) of printing the transparent orthodontic device by using a 3D printer, wherein the attachment comprises: two pressurizing surfaces (101) formed to face each other; two inclined surfaces (201) which are in contact with the two pressurizing surfaces (101) and are formed to be inclined while facing each other; an upper end surface (301) having corners, all of which are in contact with the two pressurizing surfaces (101) and the two inclined surfaces (201); and an attachment surface (401) attached to a surface of a tooth.

一种骨修复材料的制备方法

Resumen de: CN120884739A

本发明公开了一种骨修复材料的制备方法，属于生物医用材料技术领域。本发明采用Solidworks构建支架模型，利用3D打印技术制备海藻酸钠/壳聚糖/矿化胶原支架，形成具有良好成骨性能的骨修复材料；材料中海藻酸钠、壳聚糖、矿化胶原的质量比：1∶0.2~0.6∶0.2。本发明使用3D打印技术来制备支架，同时选取不同的壳聚糖浓度，以获得一系列不同性能的支架；通过研究发现，当打印墨水中壳聚糖浓度为0.01~0.03g/mL时，海藻酸钠/壳聚糖/矿化胶原打印墨水在酸性交联环境下形成稳定的支架；支架的力学性能随着壳聚糖浓度的增加，呈现上升的趋势；支架的壳聚糖浓度越低且处于pH=7.2‑7.5的环境下胶原释放越快，释放量也越大。

一种4D打印仿生假肢及其制备方法与应用

Resumen de: CN120884406A

本发明涉及一种4D打印仿生假肢及其制备方法与应用，涉及医疗康复器械技术领域，该仿生假肢包括仿生骨架和柔性驱动单元；柔性驱动单元位于仿生骨架的关节活动部位，用于驱动仿生骨架的运动；仿生假肢采用4D打印一体化成型得到，仿生骨架采用形状记忆复合材料制得，柔性驱动单元采用水凝胶驱动材料制得；形状记忆复合材料包括质量之比为(80％～95％):(5％～20％)的形状记忆聚合物和增强材料；水凝胶驱动材料包括质量之比为(50％～80％):(20％～40％):(3％～15％)的温敏性聚合物基体、稳定剂和功能性填料。本发明的4D打印仿生假肢具有动态调整能力，能够满足残肢在不同情况下的变化需求的问题。

生物基光固化聚氨酯丙烯酸酯树脂及其制备方法和应用

Resumen de: CN120888043A

本发明属于高分子材料技术领域，具体涉及一种生物基光固化聚氨酯丙烯酸酯树脂及其制备方法和应用。本发明的生物基光固化聚氨酯丙烯酸酯树脂的制备方法，包括以下步骤：(1)取催化剂、第一阻聚剂、第一丙烯酸羟基酯和衣康酸混合，在90‑120℃下搅拌反应6‑9h，得到反应产物，然后加入环氧大豆油，在90‑120℃下搅拌3‑5h，得到预聚物；(2)将步骤(1)得到的预聚物降至室温，逐滴加入第二丙烯酸羟基酯和二异氰酸酯，然后在30‑60℃下搅拌反应1.5‑4h，直至NCO红外峰值消失，即得。本发明的树脂生物基含量高，黏度适中，柔韧性好，硬度高，附着力强，光泽度高，气味小，储存稳定性好，适合应用于制备UV固化涂料、UV固化油墨、UV固化胶黏剂、3D打印材料、甲油胶。

BIOPRINTING METHODS AND SYSTEMS

Resumen de: MX2025010283A

In a bioprinting system and method, a bioprinter may include one or more reservoirs, a printhead, and a print surface on which the bioprinting is dispensed. An optical system may collect imaging data of a plurality of cells within a cross-linkable material before, during and/or after passage of the plurality of cells through the bioprinting system. A computing system may process the imaging data to determine a quantity, distribution, concentration, and/or morphology of the plurality of cells. A machine learning system compares characteristics of the plurality of cells before, during and/or after passage of the plurality of cells through the bioprinting system to user-established cell morphologies corresponding to physical properties of cells and/or cell aggregates within a predetermined tolerance. Additionally or alternatively, the machine learning system compares characteristics of the plurality of cells at one stage in the bioprinting system to characteristics of the plurality of cells at another stage in the bioprinting system.

TECHNIQUES FOR AUTOMATED MARKING OF DENTAL APPLIANCES

Resumen de: MX2025011659A

The present disclosure discusses techniques for marking a dental appliance. A dental model and dental appliance are positioned onto a conveyor tray, which is transported to a scan station. The dental model and conveyor tray each include an identifying code. The scan station includes a camera and barcode reader to read the identifying codes on the dental model and conveyor tray, and these codes are associated with one another. The conveyor tray then moves to a marking station where a barcode reader reads the code on the conveyor tray, and then marks the dental appliance with the appropriate marking.

IMPLANT

Resumen de: MX2025011378A

This invention relates to an implant (10), including a support arrangement (12) manufactured from a form of a porous material, for receiving and supporting stem cells (14) in a supported condition, for receiving a medium in the form of a neural basal and neural induction medium mixture (20) and the support arrangement (12) being shaped and sized to conform to and be received complementally by an implant zone (16). The implant zone (16) being a space defined by an excised portion of a subject's spinal cord (18). The neural basal and neural induction medium mixture (20) provides nutrients for the development of the stem cells (14) and the growth factors, in form of neurotrophin 3, neurotrophin 4 and brain-derived neurotrophic factor (BDNF) encourage and control development of the stem cells (14), the growth factors typically being constituents of the medium mixture (20).

FREMGANGSMÅDE TIL FREMSTILLING AF ET FODINDLÆG VED HJÆLP AF 3D-PRINTNING VED HJÆLP AF MÅLINGER AF FODTRYK OG MATERIALETS HÅRDHED OG/ELLER STRUKTUR FOR AT AFLASTE FODTRYKKET

Resumen de: CN114983087A

A method and apparatus for generating a custom manufactured orthotic insole or insole for footwear. Information relating to the pressure exerted by a person's plantar is used to customize the production of orthotic insoles or insoles for a particular person by using softer material or different structural components selectively located at the pressure points to remove the pressure on the foot at these points. A pressure point of a foot of an individual is identified for pressure readings acquired for the foot. The pressure points are quantized and the feet are mapped to the pressure map in a grid format. After the mapping, the structural component corresponding to the particular pressure value is placed in the orthotic insole based on the mapping. The compression unit is made via a 3D printing method based on the individual's pressure readings and the results derived with the electronic pressure plate of the pressure responsive sensor.

一种3D打印的骨组织工程支架、制备方法及其应用

Resumen de: CN120860305A

本发明涉及一种3D打印的骨组织工程支架、制备方法及其应用，属于生物材料技术领域。该方法以可生物降解的PCL材料为基体，混合金属氧化物纳米颗粒，得到制备简单、功能性强的3D打印墨水，然后采用FDM技术制备PCL骨组织工程支架。所制备的支架成型性能优，能够保证打印质量和一致性；此外，该支架生物相容性好，展现出显著的促进干细胞增殖分化和抗菌抗氧化等能力。

一种负载锰铁普鲁士蓝类似物的磷酸钙双层结构的组织工程材料及其制备方法

Resumen de: CN120860326A

本发明公开了一种负载锰铁普鲁士蓝类似物的磷酸钙双层结构的组织工程材料，制备方法为：S1、采用基体陶瓷浆料通过光固化3D打印成型，得到具有多孔结构的陶瓷湿坯；S2、对陶瓷湿坯进行梯度烧结，得到多孔陶瓷预制体；S3、将纳米磷酸钙与分散剂充分混合得到纳米磷酸钙悬液，将多孔陶瓷预制体置于纳米磷酸钙悬液中浸泡，烘干，得到双层多孔陶瓷湿坯；S4、将双层多孔陶瓷湿坯快速烧结，得到双层增强生物陶瓷；S5、将双层增强生物陶瓷置于普鲁士蓝类似物‑磷酸钙悬液中浸泡，烘干，得到负载锰铁普鲁士蓝类似物的磷酸钙双层结构的组织工程材料。本发明的组织工程材料兼顾力学性能高，表面粗糙度大以及有效缓解炎症，提高骨诱导性能等多重功效。

基于改性木竹纳米纤维素的自修复柔性传感器及其3D打印制备方法与应用

Resumen de: CN120865697A

本发明涉及基于改性木竹纳米纤维素的自修复柔性传感器及其3D打印制备方法与应用，属于柔性传感器技术领域。为解决现有柔性传感器灵敏度低、耐久性差以及无法自修复的问题，本发明提供了基于改性木竹纳米纤维素的自修复柔性传感器的3D打印制备方法：步骤一、制备改性木竹纳米纤维素；步骤二、制备3D打印浆料；步骤三、3D打印制备自修复柔性传感器。本发明柔性传感器具有多尺度导电网络结构，灵敏度和柔性应变响应能力好；动态二硫共价键的引入赋予材料可逆交联特性，受损后2.5小时内即可实现力学性能的高效恢复，具有较好的结构稳定性和抗疲劳性能。本发明以生物基木竹纳米纤维为原料，通过3D打印实现低成本、高精度的定制化制造。

3D打印可吸收骨塞及其制备方法

Resumen de: CN120860308A

本申请提供一种3D打印可吸收骨塞的制备方法，属于生物医用材料技术领域，其制备方法步骤如下：1、对聚己内酯颗粒进行干燥处理，使其含水率不高于0.5%；2、将干燥后的聚己内酯颗粒与羟基磷灰石按配比混合，获得均匀的复合材料混合物；3、将复合材料混合物加入颗粒式3D打印设备中，通过螺杆送料至喷嘴处进行熔融处理；4、按照预设的骨塞三维模型进行逐层堆叠三维打印成型，形成具有连通多孔结构的骨塞坯件；5、对骨塞坯件进行后处理，得到成型的可吸收骨塞。本申请采用聚己内酯这一具备生物降解能力的热塑性高分子材料，结合具备良好骨诱导性的羟基磷灰石，有助于构建可被生理环境逐步吸收替代的植入物基础。

官能化的重组细菌胶原样蛋白

Resumen de: WO2024188844A1

Recombinant bacterial collagen-like protein, preferably with an amino acid sequence that is at least ≥ 60% identical to the amino acid sequence of SEQ ID NO:1 wherein the amino acid sequence comprises a deletion of at least 38 amino acids at the N-terminus of the amino acid sequence of SEQ ID NO:1, wherein the recombinant collagen-like protein is functionalized with at least one non-terminal alkene group. A bioink comprising the functionalized recombinant bacterial collagen-like protein, at least one solvent and at least one photoinitiator, a process for producing a hydrogel by crosslinking the functionalized recombinant bacterial protein or the bioink as well as the hydrogel obtained therefrom. Furthermore, a scaffold for tissue engineering comprising the hydrogel.

骨再生屏障构件及制备系统

Resumen de: CN120859635A

本发明公开了一种骨再生屏障构件及制备系统，其中，一种骨再生屏障构件，包括：钉体，表面设有自攻螺纹；覆盖件，可拆卸连接在所述钉体上，所述覆盖件的尺寸和形状与患者口腔内的缺损区域形态相适配；所述钉体的内部设置有药物释放通道，所述药物释放通道设置有药物；所述钉体的外壁上设置有多个微孔，所述微孔连通外部与所述药物释放通道，以释放药物。由此，能够与缺损区域完美适配，配合单一的钉体固定，即可完成对覆盖件的安装，固定方式简单，且能够有效减少应力集中现象，同时还能够延长药物的释放时长，保证对患者的治疗效果。

一种心肌修复材料及其制备方法和应用

Resumen de: CN120860329A

本发明公开了一种心肌修复材料及其制备方法和应用。该心肌修复材料包含多个层叠的纤维层，纤维层由若干个交错的微米级纤维组成，并具有微米级孔隙；微米级纤维的表面粗糙度Ra不低于130 nm。该心肌修复材料利用自身结构特点促进M2型巨噬细胞极化并增强血管生成，无需负载外源性活性成分即可促进心肌修复，避免了使用外源性活性成分引发免疫排斥反应的问题。

ORTHODONTIC DEVICE AND PROCESS OF MANUFACTURING ORTHODONTIC DEVICE

Resumen de: US2025331960A1

An orthodontic device includes an alignment body, a support member, and a positioning mechanism connecting the support member to the alignment body. The support member includes a bracket receiving structure and is actuatable between a bonding position and a non-bonding position. A process of manufacturing an orthodontic device includes constructing an orthodontic device from data including a three-dimensional model obtained from a patient's dentition, an orthodontic prescription, and a structure of an orthodontic bracket including a bonding surface.

MANUFACTURING ALIGNERS HAVING COORDINATE SYSTEM REFERENCE MARKS

Resumen de: US2025331954A1

A method of fabricating a dental appliance includes receiving a 3D model of a mold for a dental arch of a patient, the digital three-dimensional model of the mold comprising one or more features associated with one or more coordinate system reference marks, and fabricating the mold by a rapid prototyping machine using the digital three-dimensional model, the mold having the one or more features. The method further includes thermoforming the dental appliance over the mold, wherein the one or more features cause the dental appliance to have the one or more coordinate system reference marks. The method further includes orienting, by a trimming machine, a coordinate system of the trimming machine with a coordinate system of the dental appliance using the one or more coordinate system reference marks, trimming, by the trimming machine, the dental appliance along a cut line according to a digital file comprising trimming instructions.

METHODS FOR DETERMINING ATTACHMENT PLACEMENT APPLIANCE GEOMETRY

Resumen de: US2025331953A1

Methods for determining appliance geometry are provided. In some embodiments, a method includes determining a geometry for an attachment placement appliance. The attachment placement appliance can include an appliance body including a support formed in a tooth-receiving cavity for a tooth of a patient, one or more coupling structures connected to the support, and an aligner attachment connected to the one or more coupling structures. The aligner attachment can be configured to be mounted on the tooth and shaped to engage with an attachment well of a shell aligner and exert forces on the tooth when the aligner attachment is coupled to the attachment well. The appliance body can be configured to align an aligner attachment to a predetermined location on the tooth. The method can further include generating instructions for direct fabrication of the attachment placement appliance via an additive manufacturing process, based on the determined geometry.

SURGICAL SHAFT INSTRUMENT AND METHOD FOR PRODUCING A SURGICAL SHAFT INSTRUMENT

Resumen de: WO2025223804A1

The invention relates to a surgical shaft instrument (1) with at least one jaw part (30) which is movable in at least one axis (X) and by means of which a preferably pliers-like or scissors-like tool is formed in a distal end region (9), comprising a first part (10) having a first shaft portion (20) along a shaft axis (L); a second part (40) having a second shaft portion (50) along the shaft axis (L) and a second guiding means (42) in the distal end region (9); and at least one jaw part (30) which is provided on the first part (10) in the distal end region (9), said at least one jaw part (30) having a first guiding means (32) and being provided as a single piece. The first part (10) and the second part (40) are combined such that the first guiding means (32) and the second guiding means (42) interact in such a way that when the first shaft portion (20) and the second shaft portion (50) are mutually displaced, the at least one jaw part (30) is deflected about the at least one axis (X). The invention also relates to a method for producing the surgical shaft instrument (1).

METHOD FOR ESTABLISHING A CONNECTION BETWEEN AN INSERTED DENTAL IMPLANT AND A CROWN AND METHOD FOR THE PRODUCTION OF A CROWN

Resumen de: WO2025223664A1

The aim of the invention is to devise a method for providing a connection between an inserted dental implant and a crown, which makes it particularly simple to establish a reliable and secure connection between the crown and the inserted implant. For this purpose, according to the invention, the crown is provided with an associated recess suitable for accommodating a connecting element of the dental implant. Following the insertion of the dental implant into the jawbone of the patient, the intraoral data characteristic of the oral situation of the patient including the inserted dental implant is captured. Using this intraoral data, the geometric data defining the intermediate space formed by the connecting element and the associated recess when the crown is correctly placed is determined, and, using this data, an intermediate body is produced that fills the intermediate space.

METHOD FOR ESTABLISHING A CONNECTION BETWEEN A NUMBER OF INSERTED DENTAL IMPLANTS AND A PROSTHETIC BODY

Resumen de: WO2025223663A1

The aim of the invention is to devise a method for providing a connection between a number of inserted dental implants and a prosthetic body, which makes it particularly simple to establish a reliable and secure connection between the prosthetic body and the inserted implants. For this purpose, according to the invention, the prosthetic body is provided with a recess for each dental implant, said recess being associated with the dental implant and being suitable for accommodating a connecting element of the particular dental implant. Following the insertion of the dental implants into the jawbone of the patient, the intraoral data characteristic of the oral situation of the patient including the inserted dental implants is captured. Using this intraoral data, the geometric data defining the intermediate space formed by the connecting element and the associated recess when the prosthetic body is correctly placed is determined for the connecting element of the dental implant, and, using this data, an intermediate body is produced that fills the intermediate space.

SURGICAL STAPLER CARTRIDGE WITH 3D PRINTABLE FEATURES

Resumen de: US2025331850A1

An apparatus includes a staple, a body, a staple driver, and an alignment feature. The alignment feature is coupled to or formed with at least one of the staple driver or an inner surface of the staple aperture of the body. The alignment feature is configured to minimize rotation of the staple driver. The alignment feature includes at least one of a first contact feature, an alignment member, an alignment member, or an inwardly tapering portion. The first contact feature projects beyond a first lateral side of the staple driver. The alignment member extends through at least a portion of the staple driver. The first connecting portion rigidly connects the inner surface of the staple aperture with the staple driver in a connected state. The inwardly tapering portion of the inner surface or the staple driver is configured to guide the staple driver.

LEAD CONSTRUCTION INCLUDING ALIGNABLE MARKER ELEMENTS

Resumen de: US2025332406A1

Implantable apparatus includes two or more alignable marker elements, and systems and methods for manufacturing such implantable apparatus, and methods to utilize such implantable apparatus. For example, the implantable apparatus may include a first alignable marker element and a second alignable marker element that may be used to ensure proper alignment with a target site.

Nonconductive Field Guide For Resection Cavity, And Systems And Methods Of Using Same

Resumen de: US2025332412A1

A method for treating tumor cells around a resection cavity comprises positioning a nonconductive material within a resection cavity that is adjacent to a target region. At least a first electrode and a second electrode are positioned relative to the tumor resection cavity so that electric fields between the at least one first electrode and the at least one second electrode travel through the target region. Tumor-treating electric fields are the generated between the at least one first electrode and the at least one second electrode.

MAGNETIC CUP ASSEMBLY

Resumen de: US2025332067A1

A magnetic cup includes a first cup portion including a first magnet and a second cup portion including a second magnet. A target capsule is placed between the first cup portion and the second cup portion. The target capsule is sealed with a first seal. The magnetic cup provides a second seal formed from a magnetic force between the first magnet and the second magnet. Further provided is a tool designed to assist a user for opening the magnetic cup. The tool includes a first arm including a third magnet designed to attract the first magnet through a second magnetic force greater than the first magnetic force, and a second arm including a fourth magnet designed to attract the second magnet through a third magnetic force greater than the first magnetic force.

COMPLIANT SUPPORT MECHANISM

Resumen de: US2025334162A1

There is disclosed a compliant support mechanism including a first support surface; a second support surface; and one or more flexure prongs arranged in a configuration therebetween, each flexure prong having a plurality of bends or curves along its length so as to allow the configuration of one or more flexure prongs to be resiliently compliant when subjected to external forces on the support surfaces. The one or more flexure prongs have a compliance profile dependent upon the application.

SYSTEMS, METHODS, AND DEVICES FOR PLAQUE ANALYSIS, VESSEL AND FLUID FLOW ANALYSIS, AND/OR RISK DETERMINATION OR PREDICTION THEREOF

Resumen de: WO2025226727A1

This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.

FLEXIBLE EXOSKELETON WITH PNEUMATIC ARTIFICIAL MUSCLE

Resumen de: WO2025226163A1

The present invention relates to a flexible exoskeleton having a suit with one or more pneumatic artificial muscles, wherein the pneumatic artificial muscle comprises: a flexible membrane; internal rings spaced apart from one another and wrapped inside the flexible membrane; and external rings that are coupled to the internal rings from the outside of the flexible membrane. The rings and the clips may be manufactured, for example, by means of 3D printing and the membrane may be a thin plastic film or a fabric.

PROCESS FOR OBTAINING A NEUROPROTECTIVE CONDUIT WITH CONTROLLED RELEASE OF BIOACTIVE MOLECULES FOR NERVE REGENERATION, NEUROPROTECTIVE CONDUIT AND USES THEREOF

Resumen de: WO2025222266A1

The present invention relates to a process for obtaining a biocompatible neuroprotective conduit with controlled release of bioactive molecules for nerve regeneration, comprising the steps of: 3D printing an NGC and guide tube from PCL biomaterial; sterilising the NGC; preparing GelMA functionalised with the growth factor FGF-2; inserting the guide tube into the NGC; applying GelMA functionalised with the growth factor FGF-2; photocrosslinking with a UV light head; and removing the guide tube. Furthermore, the present invention also relates to a biocompatible neuroprotective conduit with controlled release of bioactive molecules for nerve regeneration and to uses thereof.

METHOD AND APPARATUS FOR PRINTING ORTHODONTIC BRACKETS USING ULTRA FINE 3D PRINTING RESOLUTION AND VARIABLE LAYER THICKNESS

Resumen de: WO2025226761A1

The present invention relates to a method and system for fabricating customized orthodontic brackets using 3D printing technologies with ultra-fine resolution to produce the orthodontic bracket with multiple layer thicknesses, and each layer thickness ranges from 0.05 micrometers to 100 micrometers. The process involves accessing data related to a 3D CAD bracket structure model for the customized orthodontic bracket. The 3D printing technologies with adaptive slicing dynamically adjust layer thickness based on geometric complexity and surface roughness, ensuring the variable layer ranges from 0.05 micrometers to 100 micrometers. By applying variable layer thickness, the method optimizes surface roughness.

COLLAGEN-BASED FORMULATIONS USABLE AS SOFT TISSUE FILLERS AND/OR IMPLANTS

Resumen de: US2023310704A1

A three-dimensional (3D) biocompatible, degradable soft tissue implant, comprising a bioprinted composite scaffold, the composite scaffold comprising a recombinant human collagen (rhCollagen) and a biocompatible synthetic polymer and features: a porous wall; an inner cavity at least partially enclosed within the porous wall; and at least one injection port that connects the inner cavity with an outer most surface of the scaffold, wherein the injection port has an opening sized to permit insertion of an injection device through the port, processes of preparing same and uses thereof in soft tissue reconstruction are provided. Injectable matrices for use in soft tissue reconstruction, either alone or in combination with the implant are also provided.

FENESTRATION TEMPLATE FOR ENDOVASCULAR REPAIR OF AORTIC ANEURYSMS

Resumen de: US2025332794A1

To provide simple yet accurate stent graft fenestration, a patient-specific fenestration template is used as a guide for graft fenestration. To generate the fenestration template, a patient's medical imaging data such as CT scan data may be used to generate a 3-D digital model of an aorta lumen of the patient. The aorta lumen may encompass one or more branch vessels, which may be indicated on the 3-D digital model. Based on the 3-D digital model or a segment thereof, the fenestration template may be generated, for example, using 3-D printing technology. The fenestration template may include one or more holes or openings that correspond to the one or more branch vessels. To fenestrate a stent graft, the fenestration template is coupled to the stent graft so that the holes or openings on the fenestration template indicate the fenestration locations.

Chirurgisches Schaftinstrument sowie Verfahren zum Herstellen eines chirurgischen Schaftsinstruments

Resumen de: DE102024111699A1

Die vorliegende Erfindung betrifft ein chirurgisches Schaftinstrument (1) mit mindestens einem in mindestens einer Achse (X) beweglichen Maulteil (30) durch welches ein bevorzugt zangen- oder scherenartiges Werkzeug in einem distalen Endbereich (9) gebildet wird, aufweisend ein erstes Teil (10) mit einem entlang einer Schaftachse (L) angeordneten ersten Schaftabschnitt (20), ein zweites Teil (40) mit einem entlang der Schaftachse (L) angeordneten zweiten Schaftabschnitt (50) und einem im distalen Endbereich (9) angeordneten zweiten Führungsmittel (42) und mindestens ein im distalen Endbereich (9) an dem ersten Teil (10) angeordnetes Maulteil (30), wobei das mindestens eine Maulteil (30) ein erstes Führungsmittel (32) aufweist und einstückig ist, wobei das erste Teil (10) und das zweite Teil (40) derart zusammengesetzt werden können, dass das erste Führungsmittel (32) und das zweite Führungsmittel (42) derart zusammenwirken, dass bei einem gegenseitigen Verschieben des ersten Schaftabschnitts (20) und des zweiten Schaftabschnitts (50), das mindestens eine Maulteil (30) um die mindestens eine Achse (X) ausgelenkt wird. Weiterhin betrifft die vorliegende Erfindung ein Verfahren zum Herstellen des chirurgischen Schaftinstruments (1).

METHOD FOR ESTABLISHING A CONNECTION BETWEEN A NUMBER OF INSERTED DENTAL IMPLANTS AND A PROSTHETIC BODY AND METHOD FOR THE PRODUCTION OF A PROSTHETIC BODY

Resumen de: WO2025223689A1

The aim of the invention is to devise a method for providing a connection between a number of inserted dental implants and a prosthetic body, which makes it particularly simple to establish a reliable and secure connection between the prosthetic body and the inserted implants. For this purpose, according to the invention, the prosthetic body is provided with a recess for each dental implant, said recess being associated with the dental implant and being suitable for accommodating a connecting element of the particular dental implant. Following the insertion of the dental implants into the jawbone of the patient, the intraoral data characteristic of the oral situation of the patient including the inserted dental implants is captured. Using this intraoral data, the geometric data defining the intermediate space formed by the connecting element and the associated recess when the prosthetic body is correctly placed is determined for the connecting element of the dental implant, and, using this data, an intermediate body is produced that fills the intermediate space.

BIOENGINEERED CORNEAL GRAFTS

DISPOSITIVOS PARA IMPLANTAR EN EL CUERPO HUMANO Y MÉTODO PARA SU FABRICACIÓN

Resumen de: WO2025052207A1

Temporary and/or disposable device that can be implanted in the human body, including a biocompatible material implantable in the human body and including a plastic material, wherein the material includes a pharmaceutical or medical substance including at least one antibiotic and/or a radio-opacifying agent; method for the obtainment of such device and thread of 3D-printing material for the obtainment of such device.

METHOD AND DEVICE FOR PRODUCING AN ARTICLE

Resumen de: WO2024133131A1

The invention relates to a method for producing a three-dimensional article by way of an additive manufacturing method, wherein at least one manufacturing material is introduced in a flowable state into a support material from at least one introduction opening of an introduction needle and is then hardened, and a stiffening material is introduced into the support material and then hardened.

BIOMATERIAL FOR USE IN THE DENTAL FIELD

Resumen de: AU2023410422A1

The present invention relates to a crosslinkable polymer composition comprising at least one calcium phosphate, at least one biocompatible and biodegradable organic polymer or one of its precursors, and Zn-ZnO core-shell particles, to a biomaterial obtainable by photopolymerization of such a crosslinkable polymer composition, to a process for preparing such a composition and such a biomaterial, and to the use of such a biomaterial for various applications in the field of health.

A METHOD FOR PRODUCING A THREE-DIMENSIONAL MICROPOROUS FILAMENT CONSTRUCT

Resumen de: CN120265403A

A method for producing a three-dimensional macroporous filament construct having interconnected microporous filaments comprises: a) preparing a mixture comprising particles of one or more metals, one or more metal alloys, or a combination thereof, one or more binders, a first liquid solvent of the one or more binders, and optionally one or more dispersants; b) dispersing particles containing at least one removable additive in the mixture; c) depositing the mixture in the form of filaments in a predetermined three-dimensional pattern of interconnected filaments, thereby producing a filament-based three-dimensional porous green structure; d) contacting the filament-based three-dimensional porous green structure formed in step c) with a second solvent, which is a non-solvent for the one or more binders, to induce phase inversion, thereby producing a filament-based phase-inverted porous structure having filament micropores, thereby converting at least a portion of the filaments into a solid state; e) removing the at least one removable additive by dissolution in a remover to create additional micropores in the phase-inverted porous structure; f) subjecting the structure thus obtained to a heat treatment. The remover contains or consists of the second liquid solvent, or the remover is a third liquid solvent different from the second liquid solvent.

APPARATUS FOR AEROSOLISING A LIQUID

Resumen de: CN120529970A

The present disclosure provides an apparatus (100) for aerosolizing a liquid, the apparatus comprising one or more inputs (110) and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet injector includes a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with one or more inputs. Each piezoelectric actuator is operable to cause liquid received by one of the one or more inputs to be ejected through a respective nozzle outlet in the form of one or more droplets, thereby producing an aerosol comprising the one or more droplets ejected by each droplet ejector.

改良されカスタマイズされた隣接歯間接触部を有する歯科用マトリックスのデジタル設計

Resumen de: US2024325127A1

Systems and techniques for designing a digital dental matrix with improved interproximal contacts are disclosed including generating a digital three-dimensional model of a future dental anatomy of a patient, the future dental anatomy representing an intended shape of at least one tooth of the patient, selecting one or more pairs of adjacent teeth in the 3D model, for each selected pair of teeth, determining a location and orientation in the interproximal space of the adjacent teeth to insert a digital 3D geometry having one or more initial parameters, and inserting the digital 3D geometry at the determined location and orientation.

NEBULISER

Resumen de: CN120529970A

The present disclosure provides an apparatus (100) for aerosolizing a liquid, the apparatus comprising one or more inputs (110) and a plurality of droplet ejectors (126) in fluid communication with the one or more inputs (110). Each droplet injector includes a nozzle portion and a piezoelectric actuator. The one or more inputs are for receiving one or more liquids. Each nozzle portion defines a nozzle outlet in fluid communication with one or more inputs. Each piezoelectric actuator is operable to cause liquid received by one of the one or more inputs to be ejected through a respective nozzle outlet in the form of one or more droplets, thereby producing an aerosol comprising the one or more droplets ejected by each droplet ejector.

一种3D打印的水凝胶支架及其制备方法

Resumen de: CN120837725A

本发明公开了一种3D打印的水凝胶支架及其制备方法，涉及水凝胶材料技术领域，本发明为了提升水凝胶材料的抗菌性与生物相容性，对其原料进行了改性处理；本发明首先使用了明胶作为原料，并对其进行处理，增加其表面氨基含量，便于后续步骤的反应；之后，本发明还使用2,5‑噻吩二羧酸为原料，通过控制反应条件，将其与2‑氨基苯并咪唑反应，从而生成了含有游离羧基、噻吩环与咪唑环结构的抗菌中间体；并通过酰胺键的方式将其结合在明胶链段中，之后在光引发剂作用下，酰胺键断裂生成酰基自由基，进一步的与丙烯酸酯双键发生偶联接枝，从而与形成水凝胶交联结构，为水凝胶材料提供足够的压缩强度。

陶瓷贴面和用于制作陶瓷贴面的连续增材制造方法

Resumen de: WO2024180438A1

The present disclosure provides a method of making a ceramic article. The method includes (a) obtaining a photopolymerizable slurry or sol including a plurality of ceramic particles distributed in the photopolymerizable slurry or sol and (b) selectively polymerizing the photopolymerizable slurry or sol using actinic radiation and continuous movement of a build substrate through the photopolymerizable slurry or sol to form a gelled article. The method also includes (c) extracting solvent from the gelled article to form an aerogel article or a xerogel article; (d) heat treating the aerogel article or the xerogel article to form a porous ceramic article; and (e) sintering the porous ceramic article to form a sintered ceramic article. The sintered ceramic article exhibits a particular density. Further, additive manufactured ceramic articles are provided that exhibit a particular density, opacity, or both.

用于生成用于增材制造对象的支撑结构的方法

Resumen de: US2024227300A1

Methods and systems for generating support structures for additively manufactured objects are described herein. In some embodiments, a method includes receiving a digital representation of a dental appliance configured to implement a treatment stage of a treatment plan for a patient's teeth. The method can include generating a support structure arrangement configured to support the dental appliance during an additive manufacturing process. The support structure arrangement can be generated using a machine learning model. The machine learning model can be trained on a training data set including appliance data representing geometries of a plurality of dental appliances, support structure data representing geometries of a plurality of support structure arrangements, and outcome data representing outcomes of the additive manufacturing process for the plurality of dental appliances with the respective support structure arrangements.

一种宏观结构可调、多级有序的仿生凝胶及其制备方法和应用

Resumen de: CN120837722A

本发明提供了一种宏观结构可调、多级有序的仿生凝胶及其制备方法，所述仿生凝胶按照如下方法制备：步骤1：聚乙烯醇基干粉的制备；步骤2：利用步骤1得到的聚乙烯醇基干粉进行3D打印；步骤3：循环冻融；步骤4：机械训练。通过控制循环冻融和机械训练的参数，使宏观结构逐渐复杂化的水凝胶内部纤维取向方向与宏观架构方向保持一致。本发明的打印凝胶的宏观结构为非单一方向，经过循环冻融、拉伸后打印凝胶的内部纤维取向也不是单一方向的，而是沿着非单一宏观架构方向，内部纤维取向于多个方向。

一种自体髂骨取骨重建骨缺损的3D打印导板及其制备方法和应用

Resumen de: CN120837154A

本发明涉及骨缺损重建技术领域，具体涉及一种自体髂骨取骨重建骨缺损的3D打印导板及其制备方法和应用，所述自体髂骨取骨重建骨缺损的3D打印导板的制备方法包括以下步骤：基于患者肿瘤部位及骨盆的CT扫描DICOM数据，在计算机中模拟切除肿瘤并生成骨缺损区三维模型；根据所述骨缺损区模型，通过计算机辅助设计确定最佳髂骨取骨位置、大小、形状及取骨方案；依据所述取骨方案设计取骨导板及固定导板，所述导板通过3D打印技术制备。本发明将骨缺损重建的关键步骤(如肿瘤切除模拟、取骨方案设计、植骨固定模拟)均通过计算机辅助完成，形成标准化操作流程，构建了骨缺损重建的标准化解决方案。

一种可磁控细胞培养基质及其制备方法和应用

Resumen de: CN120843428A

本发明提供了一种可磁控细胞培养基质的制备方法，其包括（1）将水凝胶溶液和磁粉混合，得到墨水；（2）对所述墨水进行除泡处理和充磁磁化，得到磁性墨水；（3）使用所述磁性墨水进行3D打印，得到具有期望形状的结构；（4）对所述结构进行固化和洗涤，然后将所述结构转移并固定在细胞培养材料中，得到可磁控细胞培养基质。本发明还提供了一种可磁控细胞培养基质及其用途。本发明的可磁控细胞培养基质生物相容性高、刺激参数可调，可应用于神经修复、组织工程等领域，显著提升细胞操控的精准性和效率。

一种纳米陶瓷熟浆、制备方法及其应用

Resumen de: CN120841943A

本发明涉及无机非金属材料技术领域，具体为一种纳米陶瓷熟浆，由以下重量份数组分组成：纳米氧化铝20‑25份、纳米氧化锆5‑20份、纳米二氧化硅10‑15份、改性纤维素醚3‑5份、硅烷偶联剂KH5602‑3份、复合分散剂1‑2份、去离子水30‑40份；还包括纳米羟基磷灰石0.5‑1份、磺化石墨烯oxide0.3‑0.6份；熟浆黏度5000‑8000mPa·s，粒径跨度≤0.8，Zeta电位绝对值≥40mV。本熟浆分散稳定，成型性好，固化后力学性能均衡，功能多样，生物相容性优，克服传统产品缺陷，应用前景广。

一种磷酸钙人工骨单元及其成型装置

Resumen de: CN120840078A

本发明公开了骨修复材料技术领域的一种磷酸钙人工骨单元及其成型装置，该成型装置包括打印组件、平台以及用于驱动打印组件和/或平台移动的三轴伺服组件，其中，平台上设有若干个通过熔融物粘连支撑骨单元的支撑机构、用于回收熔融物的抽吸装置、以及用于调节支撑机构和抽吸装置位置的调节装置，通过设置管体以及加热固态熔融物的方式对骨单元进行支撑，其作用力维度更多，具有支撑力、拉力、剪切力，并且可以通过再次加热脱离粘连，以便于在骨单元打印更高时，换到其他位置进行粘连支撑；且通过设置抽吸装置，可以回收多余的液态熔融物，有效缓解其顺骨单元流下的问题。

상처 치유용 매트릭스

Resumen de: AU2023403078A1

The present invention provides articles for the improved healing of wounds, preferably burn wounds. In some preferred embodiments, the article is a matrix formed from a mixture of two or more polysaccharides, the matrix comprising an active ingredient which is an extract from differentiable cells.

ＭＥＷ組織足場

Resumen de: CN120548152A

A fused electrowriting soft tissue stent comprising: a first region having one or more groups of fibers and a second region having one or more groups of fibers; and an interface region joining the first region and the second region, the interface region being electrically written with the first region and the second region in a continuous print path such that fibers in the interface region are each joined between respective pairs of fibers in the first region and the second region.

Assemble-type Patient-Specific Implant and Method for Manufacturing Thereof

Resumen de: WO2025221095A1

The present invention relates to a prefabricated patient-customized implant inserted into and fixed to a bone defect site, wherein one end of the bone defect site is formed in a joint. The prefabricated patient-customized implant comprises: a joint connection part having an external shape corresponding to a first defect end of the one end of the bone defect site; and a fixing part integrally formed with the joint connection part and detachably coupled to a part connected to a second defect end of the other end of the bone defect site.

自供能生物3D打印生物墨水、3D打印生物活性支架及其制备方法

Resumen de: CN120827636A

本申请提供的自供能生物3D打印生物墨水、3D打印生物活性支架及其制备方法，本发明是通过在不同分子量的有机高分子聚合物与促能量代谢物质混合制备得到可控释放的自供能生物3D打印生物墨水，该墨水生物相容性好，可通过改变供能物质含量，可以被设计成以可调和时间的方式“提供”和“接受”不同的细胞代谢调节线索，实现细胞更好的迁移和黏附，并发挥功能，同时该墨水在通过3D打印构建三维支架，具有可控缓释促能量代谢物质并生成微纳孔隙，提高支架亲水性，增强复合材料的生物能量代谢活性，促能量代谢物质可以为细胞生长提供足够的营养环境，调控细胞能量代谢过程，有利于细胞的粘附、生长与增殖及功能化。

正畸托槽定位安装模组的制造方法和托槽定位安装模组

Resumen de: CN120827451A

本申请实施例涉及医疗器械制造领域，公开了一种正畸托槽定位安装模组的制造方法以及根据该方法获得的正畸托槽定位安装模组。制造方法包括：模型设计步骤：使用计算机系统在数字化牙颌模型上的预定位置上添加托槽模型，形成数字化复合模型；原型打印步骤：将数字化复合模型导入打印设备，打印生成带托槽形状的原型实体；导板初定位步骤：将预制的定位导板覆盖在原型实体上，定位导板包括若干个子导板，每个子导板对应至少一颗牙齿；辅助层制作步骤：用液态硅胶填充定位导板和原型实体上托槽之间的空隙，形成辅助层，待液态硅胶固化后，取下带辅助层的定位导板；装配步骤：将托槽附件装入带辅助层的定位导板的凹槽中，形成带托槽的定位安装模板。

一种用于储药腔的载药微球原位附着方法和系统

Resumen de: CN120827646A

本发明涉及一种用于储药腔的载药微球原位附着方法和系统，其中，方法包括：步骤S1：在钛颌骨植入体内部设计药物储存流道，并对具有药物储存流道的钛颌骨植入体进行3D打印，得到试样，其中，所述药物储存流道为用于储药与释药的储药腔；步骤S2：对所述试样中储药腔的内壁进行雾化硅油处理与激光刻蚀；步骤S3：对雾化硅油处理与激光刻蚀后的试样进行微球的选型，并使用真空干燥法实现微球的原位附着；步骤S4：对微球原位附着进行测试，以判断微球的原位附着是否有效。本发明能够实现载药微球在储药腔的原位附着，并能有效控制药物的缓释、控释和延释。

METHOD AND SYSTEM OF CREATING A REPLICA OF AN ANATOMICAL STRUCTURE

Resumen de: MX2024003829A

Creating a replica of an anatomical structure. In one embodiments a method includes: accepting pictures of the anatomical structure of a subject; creating an object file that contains an initial model of an outside surface of the anatomical structure; cutting the initial model to a predetermined exterior shape circumscribing the anatomical structure to create a positive model; creating a negative model from the positive model; placing a stem tool object on an outside surface of the negative model in relationship to an orifice, thereby creating a final negative model; placing a zeroing and angling object to align the negative model to a predetermined angle; placing a base tool object by coupling the base tool object to the outside surface; printing, by way of a three-dimensional printer, the final negative model to create a negative mold; and casting the replica of the anatomical structure using the negative mold.

3D 3D PRINTED ELECTRONIC DEVICE USING HYDROGEL AND ITS MANUFACTURING METHOD

Resumen de: KR20250152704A

본 발명은　하이드로겔을 이용한 3D 프린팅 전자소자 및 그 제조방법에 관한 것이다. 일 실시예에 따르면, 전도성 하이드로겔로 이루어진 제1 하이드로겔층; 및 상기 제1 하이드로겔층 하부에 배치되되, 피부 접착성 하이드로겔로 이루어진 제2 하이드로겔층;을 포함하는, 하이드로겔을 이용한 3D 프린팅 전자소자가 제공될 수 있다.

OPTICAL MICROSCOPE APPARATUS FOR HIGH-RESOLUTION LOCAL SPECTRUM ANALYSIS

Resumen de: KR20250153100A

본 발명의 일실시예에 따른 중공형 마이크로니들의 제조 방법은, 제조하고자 하는 중공형 마이크로니들에 대응하는 형상의 캐비티가 구비된 PDMS 몰드를 제조하는 단계, 상기 중공형 마이크로니들의 중공홀에 대응하는 형상의 스트링 구조물이 구비된 스트링 구조물 몰드를 제조하는 단계, 상기 스트링 구조물 몰드와 상기 PDMS 몰드를 결합하는 단계, 상기 스트링 구조물 몰드와 상기 PDMS 몰드의 사이에 레진을 주입 및 경화시켜 상기 중공형 마이크로니들을 형성하는 단계, 및 상기 PDMS 몰드를 제거한 후 상기 스트링 구조물 몰드를 용해액으로 녹여 상기 중공형 마이크로니들을 획득하는 단계를 포함한다.

一种3D打印紫外光交联田菁胶水凝胶支架及制备方法和应用

Resumen de: CN120827641A

本发明为一种3D打印紫外光交联田菁胶水凝胶支架及制备方法和应用，所述田菁胶水凝胶为甲基丙烯酸酯化田菁胶水凝胶。所述制备方法包括以下步骤：甲基丙烯酸酐改性田菁胶水凝胶原料，经透析、冻干，获得甲基丙烯酸酯化田菁胶粉末；接着用含光引发剂的PBS进行溶解得到水凝胶；将所得水凝胶与干细胞复合，经过生物3D打印机打印后进行紫外光交联，即得所述田菁胶水凝胶支架产物。所述支架复合经软骨诱导液诱导的干细胞，有潜力应用于软骨修复工程。本发明具有生物相容性好、安全性强、材料性能可控、成本低、来源广、操作简单等优点。

HEAD ORTHOTIC WITH HINGE ASSEMBLY AND CLASP

Resumen de: US2025325385A1

A system for manufacturing a cranial remodeling orthosis (CRO) includes a scan device, a 3D printer, and processing circuitry. The scan device is configured to obtain scan data of a patient's head. The processing circuitry is configured to obtain the scan data of the patient's head. The processing circuitry is configured to use computer assisted design to generate a print file of the CRO based on the scan data, where the CRO includes at least one integrated closure mechanism. The 3D printer is configured to perform additive manufacturing to produce the CRO using the print file of the CRO.

CUSTOM SEGMENTED INDIRECT BOND TRAYS

Resumen de: WO2025222183A1

Some embodiments relate to techniques of designing indirect bonding (IDB) trays that compensate for factors that affect the bonding success of orthodontic appliance(s) using IDB trays. The techniques apply optimization rules to an IDB tray design to optimize the transfer accuracy of orthodontic appliance(s) to a patient's teeth using IDB tray(s) of the IDB tray design. For example, the techniques may compensate for movement of teeth relative to an initial scan, narrow/wide central arches, teeth planned for extraction, and/or other factors. The techniques may, for example, customize segmentation of IDB trays in an IDB tray design to compensate for factors that affect bonding success.

POPULATION BASED EYEWEAR FITTING

Resumen de: US2025328030A1

Certain aspects provide a method for creating a discrete set of variants of a customizable wearable object, comprising: receiving a baseline 3D design file for a baseline 3D customizable wearable object; obtaining a fitting population comprising a set of 3D anatomy models representing potential wearers of the customizable wearable object; generating a plurality of modified 3D customizable wearable objects based on fitting the baseline 3D customizable wearable object to each 3D anatomy model of the set of 3D anatomy models; selecting one or more of the plurality of modified 3D customizable wearable objects as the discrete set of variants of the customizable wearable object; and generating a set of 3D design files corresponding to the discrete set of variants of the customizable wearable object.

CRYSTALLIZABLE RESINS

Resumen de: US2025326927A1

This disclosure provides polymeric materials comprising polymer crystals, methods and resins for making the same, and objects and appliances made from said polymeric materials. Polymeric materials having polymer crystals provide favorable properties, such as enhanced durability and rigidity. This disclosure also provides polymeric materials comprising a crystalline phase comprising at least one polymer crystal, as well as an amorphous phase comprising at least one amorphous polymer. The crystalline phase can confer rigidity to the polymeric material, while the amorphous phase can confer elasticity and flexibility.

Breakaway Covers for Use in Processing Build Structures With Porous Regions

Resumen de: US2025326036A1

An in-process build structure includes a first build structure portion, a second build structure portion, and a cover. The second build structure portion is attached to the first build structure portion and defined by a plurality of porous portion struts. The cover at least partially overlies the second build structure portion and is attached to a remainder of the build structure by breakaway struts having breakaway strut diameters less than porous portion strut diameters of the porous portion struts. The in-process build structure is subjected to a surface treatment while the cover is attached to a remainder of the in-process build structure. The cover is removed from the remainder of the in-process build structure after the surface treatment.

SYSTEMS, METHODS, AND DEVICES FOR PLAQUE ANALYSIS, VESSEL AND FLUID FLOW ANALYSIS, AND/OR RISK DETERMINATION OR PREDICTION THEREOF

Resumen de: US2025329015A1

This disclosure relates to systems, methods, and devices for plaque analysis, vessel and fluid flow analysis, and/or risk determination or prediction thereof. Some embodiments relate to determining fractional flow reserve (FFR) values. Some embodiments relate to determining FFR values using 3D-printed models. Some embodiments relate to identifying thin cap fibroatheroma based on analysis of computed tomography (CT) imaging. Some embodiments relate adjusting calcified plaque thresholds for CT images to address effects of calcium blooming.

METHOD AND APPARATUS FOR PRODUCING A MESOSTRUCTURAL ELEMENT AND METHOD FOR DENTAL RESTORATION IN AN ORAL CAVITY

Resumen de: WO2025219028A1

Method and apparatus for producing a mesostructural element and method for dental restoration in an oral cavity The invention relates to a method for producing a mesostructural element (3), the mesostructural element (3) being adapted to be fixed to at least one oral implant and to carry at least one suprastructure for prosthetic replacement of a plurality of teeth in an oral cavity, the method comprising: ˗ arranging at least one implant proxy element (17) at a predetermined position in a jawbone model (7), ˗ attaching at least one preform element (19) to the at least one implant proxy element (17), ˗ forming the mesostructural element (3) onto the at least one preform element (19) by laser metal deposition, wherein ˗ the jawbone model (7) and a LMD nozzle (11) are positioned relative to each other by a positioning apparatus (13) comprising at least four axes, and ˗ releasing the at least one preform element (19) from the at least one implant proxy element (17) and obtaining the mesostructural element (3).

SURGICAL GUIDES WITH REMOVABLE INSERTS

Resumen de: US2025325284A1

The present disclosure describes a surgical guide comprising a cutting guide defining a plurality of cutting slots and including at least one removable insert positioned between the plurality of cutting slots. The at least one removable insert defines an aperture which is designed to receive a surgical fastening device. The surgical guide further comprises a template guide which defines a feature. The at least one removable insert is designed to fit in the template guide at least in part using the feature.

3D PRINTING MOUTH PIECE INCLUDING SIMULATION OF DEFORMATION

Resumen de: US2025325353A1

A method for manufacturing a mouth piece, in particular by jetting droplets of a first droplet material and a second droplet material in a 3D printing process. The method comprises a step of obtaining dental data of a user and an input mouth piece model. A simulation is carried out to determine a deformation of the input mouth piece model in response to an exerted force. Based on the deformation, the input mouth piece model is adapted to a work mouth piece model by substituting material of at least a portion of the input mouthpiece model by a replacement material. Finally, the mouth piece is manufactured based on the optimised work mouth piece model.

BONE FASTENER WITH A DIVERGING CANNULATION

Resumen de: US2025325314A1

A cannulated bone fastener (10) for engagement into a target bone and/or target bone fragment is provided. According to one embodiment. the cannulated bone fastener (10) comprises an elongated shaft (11) extending between a bone fastener tip or tip section and a bone fastener head or head section. a central cannulation (17) having a cannulation entry with a first cross-sectional area (A1) at the shaft tip section, and a cannulation exit with a second cross-sectional area (A2) at the head section, and wherein the first cross-sectional area (A1) is different from the second cross-sectional area (A2), and wherein the surface roughness of the cannulation wall is at most 25 micrometres.

CUSTOM SEGMENTED INDIRECT BOND TRAYS

Resumen de: US2025325351A1

Some embodiments relate to techniques of designing indirect bonding (IDB) trays that compensate for factors that affect the bonding success of orthodontic appliance(s) using IDB trays. The techniques apply optimization rules to an IDB tray design to optimize the transfer accuracy of orthodontic appliance(s) to a patient's teeth using IDB tray(s) of the IDB tray design. For example, the techniques may compensate for movement of teeth relative to an initial scan, narrow/wide central arches, teeth planned for extraction, and/or other factors. The techniques may, for example, customize segmentation of IDB trays in an IDB tray design to compensate for factors that affect bonding success.

POST-PROCESSING OF BIOLOGICAL SCAFFOLDS

Resumen de: AU2024238878A1

A method of modifying a surface of a three-dimensional (3D) article includes immersing at least one part of the 3D article in a buffered solution of functionalized peptides, allowing reaction between the functionalized peptides and reactive groups on the surface of the 3D article; and washing the at least one part of the 3D article to remove unreacted functionalized peptides. The surface-modified 3D article includes a plurality of peptides covalently bonded to the surface of the 3D article via a cysteine bridge. The surface- modified 3D article can be used as a scaffold for the formation of biological tissue or bodily implants.

ALGINATE MICROBEADS, METHODS FOR THEIR PREPARATION, AND BIOINK FORMULATIONS CONTAINING THE SAME.

Resumen de: WO2025219066A1

Provided are methods for preparing alginate microbeads that are particularly suitable as porogens for pore-forming hydrogel containing bioink formulations. Further provided are alginate microbeads obtainable by saidmethods, bioink formulations containing the same, and a method for producing a porous three-dimensional object using said bioink formulation.

FINISHED PHARMACEUTICAL FORM WITH INDIVIDUAL MEDICINE DOSING CAPABILITY (EMBODIMENTS) AND METHODS OF ITS PRODUCTION AND USE

Resumen de: US2025325451A1

According to some embodiments, a method and system are provided comprising receiving a first quantity of at least one medicine in at least one cartridge of a plurality of cartridges of a printing device; receiving a porous media in the printing device; dispensing a first drop of the at least one medicine onto the porous media; and drying the dispensed drop on the porous media. Numerous other aspects are provided.

DENTAL ALIGNERS AND RELATED MANUFACTURING METHOD

Resumen de: EP4635446A1

The invention is a new set of dental aligners (A), wherein each aligner (A) is manufactured joined to one or more aligners (A) intended for the same patient and suitable for progressive use by the same patient. The present patent also concerns the method for making the set of aligners (A) together with the connecting appendages (A) between the aligners (A) making up each set.

TRANSFER APPARATUS FOR ORTHODONTIC APPLIANCES AND RELATED METHODS OF MANUFACTURING

Resumen de: WO2024127105A1

Method of making a transfer apparatus includes providing a physical mockup having a shape that corresponds to a positive shape of a patient's dental arch and one or more orthodontic appliances connected to the arch via one or more sprues. A transfer apparatus may be formed over the physical mockup, with the transfer tray representing a negative replica of at least a portion of the mockup. The transfer apparatus may be used to seat the appliance on a patient's dental arch, after which point the appliance can be separated from transfer apparatus and bonded to the associated tooth.

DEVICE FOR MANUFACTURING BIOINK

Resumen de: EP4635526A1

A bio-ink manufacturing device according to the present disclosure is provided. The bio-ink manufacturing device include: a reaction vessel for performing a reaction on tissues of decellularized extracellular matrix and an ink solution; a bio-ink liquefy portion for stirring and compacting the tissues of decellularized extracellular matrix and liquefying the same into bio-ink; and a bio-ink discharge portion discharging the bio-ink whose liquefaction is completed to an outside of the reaction vessel.

OPHTHALMIC LENSES METHODS OF MANUFACTURING THE OPHTHALMIC LENSES AND METHODS OF DISPENSING EYE CARE PRODUCTS INCLUDING THE SAME

Resumen de: TW202449426A

Ophthalmic lenses and method of manufacturing ophthalmic lenses are disclosed.

METHOD AND APPARATUS FOR PRODUCING A MESOSTRUCTURAL ELEMENT AND METHOD FOR DENTAL RESTORATION IN AN ORAL CAVITY

Resumen de: EP4635447A1

The invention relates to a method for producing a mesostructural element (3), the mesostructural element (3) being adapted to be fixed to at least one oral implant and to carry at least one suprastructure for prosthetic replacement of a plurality of teeth in an oral cavity, the method comprising:- arranging at least one implant proxy element (17) at a predetermined position in a jawbone model (7),- attaching at least one preform element (19) to the at least one implant proxy element (17),- forming the mesostructural element (3) onto the at least one preform element (19) by laser metal deposition, wherein- the jawbone model (7) and a LMD nozzle (11) are positioned relative to each other by a positioning apparatus (13) comprising at least four axes, and- releasing the at least one preform element (19) from the at least one implant proxy element (17) and obtaining the mesostructural element (3).

一种关节假体及其制备方法

Resumen de: CN120814940A

本发明涉及一种关节假体及其制备方法，包括3D打印关节假体，所述3D打印关节假体包括假体关节和与其相连的假体柄，所述假体关节的表面喷涂有聚醚醚酮。本发明3D打印的关节假体表面达到预热温度后，使用火焰喷涂将聚醚醚酮粉末喷涂在假体关节表面，假体关节面形成牢固、坚硬致密具有晶体结构的聚醚醚酮涂层，有利于骨骼关节面的相互接触，同时未喷涂部位可以利用医用金属的生物相容性。实际使用过程中，接触面是聚醚醚酮与软骨接触，摩擦因数将下降到0.235左右，大幅提高了接触表面的光滑度。同时聚醚醚酮具有水润滑特性，有益于表面有组织液流动，比医用金属表面更具备润滑性，更有益于植入体与原生骨骼组织的表面接触。

一种用于挤压式3D打印的磷酸镁骨水泥及其制备方法和应用

Resumen de: CN120817743A

本发明涉及磷酸镁骨水泥及其3D打印技术领域，公开了一种用于挤压式3D打印的磷酸镁骨水泥及其制备方法和应用，包括固相粉末和固化液，所述固相粉末包括如下质量份数的原料：磷酸钙70~200份、磷酸镁10~90份、三水合磷酸氢镁30~150份、磷酸盐20~90份、锁水剂0.1~2份；所述固化液和固相粉末的液固比为0.45~0.8g/ml。制备时，将固相粉末混合均匀后，加入固化液，搅拌1~5 min完成反应，即得用于挤压式3D打印的磷酸镁骨水泥。本方案制备所得磷酸镁骨水泥在3D打印后，有效提升MPC挤出流动性与挤出后的形状保持能力，增加MPC打印过程中层间结合力，成功实现磷酸镁骨修复支架形状可控化。

一种丝素蛋白基拓扑结构导电水凝胶及其制备方法与应用

Resumen de: CN120818247A

本发明涉及柔性电子材料技术领域，公开了一种丝素蛋白基拓扑结构导电水凝胶及其制备方法与应用，由以下组分构成：以rGO@SilMA为聚合主体，其中所述rGO@SilMA通过将丝素蛋白与氧化石墨烯分散液混合，并在甲基丙烯酸甘油酯存在下反应形成，聚乙二醇二丙烯酸酯为增强相，苯基‑2,4,6‑三甲基苯甲酰基磷酸锂（LAP）为光引发剂，各组分在光固化墨水中的质量占比为：rGO@SilMA20%、PEGDA10%、LAP0.75%。本发明通过构建rGO@SilMA‑PEGDA互穿网络结构并引入TPMS拓扑设计，显著提升了水凝胶的力学性能与传感稳定性，互穿网络使压缩模量提升且断裂伸长率保持高水准，满足高形变场景需求，拓扑结构的负高斯曲率特征让应力分布更均匀，增加有效传感区域。

COLLAGENBASEREDE FORMULERINGER, DER KAN ANVENDES SOM BLØDE VÆVSFYLDSTOFFER OG/ELLER IMPLANTATER

Resumen de: US2023310704A1

A three-dimensional (3D) biocompatible, degradable soft tissue implant, comprising a bioprinted composite scaffold, the composite scaffold comprising a recombinant human collagen (rhCollagen) and a biocompatible synthetic polymer and features: a porous wall; an inner cavity at least partially enclosed within the porous wall; and at least one injection port that connects the inner cavity with an outer most surface of the scaffold, wherein the injection port has an opening sized to permit insertion of an injection device through the port, processes of preparing same and uses thereof in soft tissue reconstruction are provided. Injectable matrices for use in soft tissue reconstruction, either alone or in combination with the implant are also provided.

Patient-specific tibial pin guide and method of making it

Resumen de: KR20250150436A

환자 맞춤형 경골 핀 가이드 및 이를 제작하는 방법에 관한 것으로, 특히 경골 트라이얼 플레이트의 위치를 결정하는 핀 삽입공을 갖는 환자 맞춤형 경골 핀 가이드 및 이를 제작하는 방법이 개시된다. 본 발명에 따른 환자 맞춤형 경골 핀 가이드는 경골 3D 모델의 근위면 상면, 전면 그리고 후면 각각의 표면 일부 형상에 대응되는 상면부, 전면부 그리고 후면부를 구비하여, 경골 3D 모델을 감싸는 본체부로 구성되며, 상기 상면부는 상면 내측 접촉면과 상면 외측 접촉면을 포함하여 구성되고, 상기 상면 내측 접촉면과 상면 외측 접촉면이 형성된 부위는 경골 근위면에 접촉되지 않는 제1 브릿지부에 의해 연결 구성되며, 상기 후면부는 후면 접촉면을 포함하여 구성되고, 상기 상면부의 상기 상면 내측 접촉면이 형성된 부위와 상기 후면부의 후면 접촉면이 형성된 부위는 경골 근위면 및 후면에 접촉되지 않는 제3 브릿지부에 의해 연결되고, 상기 상면부의 상기 상면 내측 접촉면과 상기 상면 외측 접촉면 주위에는 경골 트라이얼 플레이트의 핀홀 위치 가이드를 위한 상면 돌출부와 상면 핀 삽입공이 형성된다.

METHOD FOR MANUFACTURING A DENTAL OBJECT

Resumen de: JP2023159033A

To provide a manufacturing method of orienting a digital dental object so as to be capable of efficient manufacture.SOLUTION: A manufacturing method of dental objects includes: a step which generates a digital dental object in a coordinate system describing a shape of a dental object to be manufactured; a step which rotates a spatial orientation of the digital dental object in the coordinate system on the basis of a digital reference object in the coordinate system; and a step which manufactures the dental object on the basis of the digital dental object having the rotated spatial orientation.SELECTED DRAWING: Figure 1

一种基于3D打印的生物牙根支架及其制备方法与应用

Resumen de: CN120789332A

本发明公开了一种基于3D打印的生物牙根支架及其制备方法与应用，属于生物医用材料技术领域。所述生物牙根支架包括3D打印的生物牙根支架基体和CMC‑BAPE@BMP7纳米颗粒，所述3D打印的生物牙根支架基体表界面具有活化的纳米晶须结构，所述CMC‑BAPE@BMP7纳米颗粒吸附固定在所述3D打印的生物牙根支架基体中。本发明结合了3D打印制备高精度生物陶瓷、高温烧结后优良力学性能、表界面活性改建促进细胞黏附分化以及结合抗炎促细胞分化纳米CMC‑BAPE@BMP7药物，实现了高强度、高精度、免疫调节活性的生物牙根支架的个性化定制，在牙缺失修复领域具有广阔的应用前景。

数字化3D打印多功能正中颌托盘及其使用方法

Resumen de: CN120788767A

本申请实施例提供数字化3D打印多功能正中颌托盘及其使用方法，涉及到口腔用具技术领域。数字化3D打印多功能正中颌托盘及其使用方法，包括：周侧带有半环形边沿的主托体，主托体上表面开设多个浅槽和多个第一通孔，多个浅槽和多个第一通孔错开分布；主托体的弧形中部内侧开设有顶部开口的插槽，插槽内阻尼插接有抬高体，抬高体向主托体中部一侧逐渐凸起，且抬高体的边缘与主托体边缘重合；主托体背侧可拆卸连接有连接块，连接块远离主托体的一侧设置有手柄，本发明通过模块化的设计，实现该正中颌托盘的多功能应用，在不同的使用需求下均能够更精确的获取颌位关系，且调整方便快捷，实际使用效果更佳。

一种外科钛合金融合器活性涂层的制备方法

Resumen de: CN120789330A

本发明公开了一种外科钛合金融合器活性涂层的制备方法，包括以下步骤：S1.通过3D打印制备多孔结构的钛合金融合器；S2.在钛合金融合器表面构建聚多巴胺涂层；S3.制备钙磷沉积液，在聚多巴胺涂层上进行羟基磷灰石矿化；S4.在羟基磷灰石矿化涂层表面接枝TBMP2蛋白，即完成钛合金融合器活性涂层的制备。本发明解决现有钛合金融合器生物惰性、骨整合性能差以及BMP2应用中副作用多的问题，并能够适应个性化植入需求。

PATIENT-SPECIFIC GLENOID PROSTHESES FOR PARTIALLY MODIFIED SCAPULA

Resumen de: WO2025215550A1

A method comprises outputting a user interface of a surgical planning system, wherein the user interface represents a patient-specific glenoid prosthesis at a planned implantation position on a scapula of a patient; and determining a bone-facing surface of the patient-specific glenoid prosthesis having a native-facing portion and a modified-facing portion, wherein the native-facing portion is shaped to conform to an unmodified bone surface of the scapula and the modified-facing portion is shaped to conform to a modified bone surface of the scapula.

Drug-eluting surgical articles and related methods

Resumen de: AU2025237992A1

Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer. Disclosed herein is a biomaterial and a method of use thereof for treating a condition. A biomaterial of the disclosure can be, for example, a surgical article. Implantation of a biomaterial disclosed herein into a subject can treat, for example, cancer. ep e p i s c l o s e d h e r e i n i s a b i o m a t e r i a l a n d a m e t h o d o f u s e t h e r e o f f o r t r e a t i n g a c o n d i t i o n b i o m a t e r i a l o f t h e d i s c l o s u r e c a n b e , f o r e x a m p l e , a s u r g i c a l a r t i c l e m p l a n t a t i o n o f a b i o m a t e r i a l d i s c l o s e d h e r e i n i n t o a s u b j e c t c a n t r e a t , f o r e x a m p l e , c a n c e r

VEHICLE FOR NON-ANTIMICROBIAL COMPOSITION

Resumen de: WO2025215377A1

The present disclosure relates generally to wound care, and more particularly to a wound dressing or debridement tool comprising an absorbent layer at least partially impregnated or coated with a non-antimicrobial composition.

SYSTEM FOR PROVIDING A BIOINK

Resumen de: WO2025215103A1

The present invention relates to a system for providing a bioink. The system comprises: a) at least two spray configured to receive at least two syringes comprising a nozzle each, each syringe configured to receive one or more components of the bioink; b) a housing, configured to comprise the at least two spray heads and comprising at least two housing nozzles, the housing nozzle comprising a diameter bigger than the diameter of the spray head nozzle; c) a gas inlet connected to the housing configured to receive a gas; and d) a control system.

NOVEL FIBRINOGEN-BASED BIOINKS FOR WOUND HEALING AND TISSUE REGENERATION

Resumen de: WO2025215084A1

The present invention relates to a bioink formulation comprising fibrinogen and a glycosaminoglycans (GAGs)/collagen (Col) matrix, preferably comprising human cells, preferably human mesenchymal stem cells (hMSCs), keratinocytes and/or human dermal fibroblasts (hDFs), and its use in the treatment of tissue or bone injuries or damages, specifically skin tissue injuries or damages.

METHOD FOR ADDITIVE MANUFACTURING OF A 3D ITEM BY MEANS OF FUSED DEPOSITION MODELING AND ADDITIVE MANUFACTURING APPARATUS

Resumen de: WO2025214921A1

The invention relates to a method and an apparatus (1) for additive manufacturing of a 3D item (2) by means of fused deposition modeling of a composite material, whereby the composite material is fed through a heated printer extruder head (4) and deposited on a printer bed (3) as a layer arrangement that form the 3D item (2). The composite material is provided as at least one rigid rod (10) that is conveyed out of a rod magazine (9) that is capable of storing at least one rigid rod (10). The rigid rod (10) is then conveyed through a guide tube (15) that is arranged within the printer extruder head (4), whereby the rigid rod (10) is heated during the conveyance through the guide tube (15), and whereby the heated and viscous composite material is discharged through a discharge nozzle (16) at one end of the guide tube (15) and deposited as the layer arrangement onto the printer bed (3) to generate the 3D item (2).

MULTIMATERIAL BIOPRINTING DEVICE

Resumen de: WO2025215267A1

The invention relates to a multimaterial bioprinting device, which comprises a rotary platform (1) on which a plurality of vessels (2) is arranged, the vessels containing different biomaterials for printing, such that the rotary platform (1) is designed to rotate each vessel (2) to a printing area (3); an arm (4) with a support (5) in the printing area, such that the arm (4) is vertically moveable; a digital light processing system designed to direct a light towards the printing area (3); and a processor (11) configured to manage the vertical movement of the arm (4) and to manage the light of the digital light processing system, wherein the printing area (3) is designed such that the light of the digital light processing system makes contact with the extracted biomaterial through the support (5) of the vessels (2).

SYSTEM FOR CUSTOM IMPLANT DESIGN AND INSTRUMENTATION

Resumen de: WO2025217154A1

Systems and methods include a component of a bone implant that includes a patient specific bone contacting surface and, optionally, at least one protrusion adjacent to or extending from the patient specific bone contacting surface. The at least one protrusion is configured for engaging a bone preparation in the bone. To prepare the bone for receiving the component, one or more cutting tool templates may be used. The one or more cutting tool templates may be fabricated to have a patient specific bone contacting surface that engages the bone that is to receive the implant component. A cutting tool is engaged in one or more of one or more slots defined by the cutting tool template(s) to remove surface portions of the bone to create the bone preparation for engaging the protrusion. The patient specific bone contacting surface of the component engages the bone.

Ink formulation, method of producing the same and uses of the ink formulation

Resumen de: US2025320367A1

The present invention relates to ink formulations based on methacrylated cellulose nanofibrils. In particular, the present invention concerns ink formulations for 3D printing, comprising a hydrogel containing methacrylated cellulose nanofibrils and preferably a cross-linking agent, optionally together with biological material, methods of producing such ink formulations, as well as uses thereof for, e.g., preparing 3D hydrogel scaffolds for cell culture and drug screening.

PROCESS FOR PRODUCING A THREE-DIMENSIONAL STRUCTURE

Resumen de: US2025319654A1

A process for producing a three-dimensional structure involves providing a light source, coupling the light source to a proximal end of an optical fibre to propagate a light generated by the light source through the optical fibre and produce, at a distal end of the optical fibre, a predetermined incident optical field, providing a photo-crosslinkable polymeric material coated with a transparent material having a first surface in contact with the photo-crosslinkable polymeric material and a second surface not in contact with the photo-crosslinkable polymeric material and opposite to the first surface, placing the distal end of the optical fibre at a distance D from the second surface of the transparent material, and irradiating the second surface of the transparent material with the light propagated and exiting the distal end of the optical fibre, obtaining propagation of the light through the transparent material and photo-crosslinking, by irradiation, of the polymeric material.

PORTABLE PRINTER

Resumen de: US2025319710A1

A portable printer including a body accommodating a cartridge including a printing material, a nozzle configured to deliver the printing material to a target, a seating part facing a surface of the target, a roller on a lower portion of the body such that the body is moved on the surface of the target, and a printing adjustment part configured to maintain a height difference between the nozzle and the roller in a first height or a second height, wherein the printing adjustment part is configured to preset a height difference between the nozzle and the roller.

SMART CUSTOMIZABLE THERAPEUTIC MECHANISMS AND SYSTEMS FOR TISSUE REGENERATION AND GROWTH

Resumen de: US2025319234A1

An embodiment herein provides a therapeutic mechanism for tissue regeneration and therapeutic monitoring. The therapeutic mechanism may include a biocompatible ink configured to transition from an initial state to a structured form in response to interaction with predefined physiological stimuli post injection into a target recipient. The therapeutic mechanism may include one or more therapeutic agents and a bio-sensing matter that may be configured to detect at least one biological parameter of the target recipient post transition of the biocompatible ink into the structured form.

PROCESSES FOR MAKING CLEAR DENTAL ALIGNERS AND CLEAR DENTAL ALIGNERS PRODUCED BY THE PROCESSES

Resumen de: US2025318907A1

Processes for producing dental aligners and/or appliances and dental aligners and/or appliances produced by the processes are provided, wherein the processes comprise making a scan of teeth of a patient and developing a treatment plan for moving at least one tooth of the teeth from an original or first position to a new, final, or second position. The processes further comprise developing a force vector matrix, wherein the force vector matrix comprises all variables that are known to contribute to force generation of an orthodontic appliance on a patient's tooth, and 3D printing the dental aligner or appliance based on the developed treatment plan, the developed force vector matrix, and/or the scan of the teeth of the patient.

APPARATUS AND PROCESS FOR MANUFACTURING A MEDICAL DEVICE AT POINT OF CARE

Resumen de: AU2024231554A1

Aspects in accordance with the present invention pertain to an apparatus for manufacturing a medical device, said apparatus comprising at least two production modules, at least one integrating element, and at least one inspection gate, wherein the production module is configured to process the medical device, a medical device part, a medical device accessory, a medical device preform, or a raw material; the integrating element is configured to, between any two of the production modules, move the medical device, the medical device part, the medical device accessory, or the medical device preform; and the inspection gate is configured to, outside the production module, subject the medical device, the medical device part, the medical device accessory, or the medical device preform, to an inspection technique according to a predetermined inspection mode, the operations of said production modules, said integrating element, and said inspection gate, being administered by a controlling software, and said apparatus is constructed as a ready-to-transport compact unit.

A METHOD FOR PRODUCING AND USING A COMPLEX FLUID

Resumen de: AU2023458708A1

Disclosed is a method for producing bubbly liquid material that is suitable for being used as a supporting material in a 3D printing system, the method comprising, producing to liquid material primary bubbles, stabilizing the primary bubbles with cross-linking enhancing compound, producing secondary bubbles to the liquid material, and using the liquid material comprising the primary and secondary bubbles as the supporting material for printing a 3D object, wherein the liquid material comprises a bubble system comprising at least the primary and secondary bubbles.

DEVICE AND METHOD FOR PRODUCING A PHARMACEUTICAL PRODUCT

Resumen de: WO2025214546A1

The invention relates to a device (10) and a method for producing a pharmaceutical product for direct dispensing to a patient. The device has a plurality of containers (24) for receiving in each case one pharmaceutical active ingredient, wherein the pharmaceutical active ingredients differ from one another; and at least one dosing device (25) for providing a specific amount of at least one of the pharmaceutical active ingredients from at least one of the containers (24); at least one processing device (28) for shaping the pharmaceutical product from the determined amount of the at least one pharmaceutical active ingredient provided by the at least one dosing device (24); a control unit connected to the dosing device (25) and the processing device (28) for controlling the production of the pharmaceutical product; a control panel (14) connected to the control unit for requesting a dispensing of the pharmaceutical product by the patient; and a dispensing unit (16) for dispensing the pharmaceutical product. By means of the device (10), personalised medicaments or pharmaceutical products can be produced at any time and dispensed directly to a patient.

3D FAT TISSUE STRUCTURE, PRODUCED USING LIGHT-BASED STRUCTURING CURING, FOR USE AS A BREAST IMPLANT

Resumen de: CN120322257A

The present invention relates to a 3D adipose tissue scaffold for use as a breast implant for surgical, therapeutic, prophylactic or aesthetic recovery, construction or replacement of human breast tissue, in which the 3D adipose tissue scaffold has a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of biological cell types, wherein the colonization of the plurality of cell types is carried out during the formation of a matrix made of a biocompatible polymer, accompanying the formation of a network of vascular structures within the 3D adipose tissue scaffold. Light-based structured curing of a photo-polymerizable or photo-crosslinkable liquid is used to build a matrix composed of a biocompatible polymer. The invention also relates to the use of a 3D adipose tissue scaffold as a human breast implant, the 3D adipose tissue scaffold having a matrix consisting of a biocompatible polymer, the matrix being colonized with a plurality of cell types, the colonization of the plurality of cell types being carried out in the process of forming the matrix consisting of a biocompatible polymer, the present invention relates to a 3D adipose tissue scaffold, in which a network of vascular structures is formed within the 3D adipose tissue scaffold, characterized in that a matrix consisting of a biocompatible polymer is constructed by means of light-based structured curing of a photopolymerizable or photocrosslinkable liquid.

Patient-specific humeral head guide device and systems and method for manufacturing same

Resumen de: GB2640326A

A patient-specific humeral head guide device may be designed and manufactured to contour the shape of a patient’s humeral head from medical images. A humeral shaft is identified and two or more points along the shaft used to define a humeral axis along with a colinear point based on a centre of lesser tuberosity. A humeral sagittal plane is identified, as is a coplanar anterior axis. A resection plane is also identified based on the sagittal plane and an angle of inclination from the longitudinal axis. Computer aided manufacturing (CAM) printing instructions are generated to print a resection channel for a cutting device. The humeral head contouring body may be of loop style and may have an extended footprint to contour a portion of lesser tuberosity. There may be fixation wire channels, at least one of which permits visual confirmation that a patient forearm aligns with an anterior axis. There may be a channel for receiving an intermedullary reamer aligned to a humeral canal centre. The CAM instructions may include G-code that causes a three-dimensional (3D) printer to manufacture a patient-specific humeral head guide device and for other various portions of the device.

SYSTEM FOR EDGE CASE PATHOLOGY IDENTIFICATION AND IMPLANT MANUFACTURING

Resumen de: WO2024151669A1

Systems and methods for identifying edge case pathologies for inspection in a patient-specific orthopedic implant procedure are disclosed. A system can analyze patient data, such as implant data, pre-operative data, post-operative data, or implant manufactured data to identify edge case pathologies in the patient data that can affect installing an implant in the patient. Based on the type of edge case pathology, the system sends a notification for a human, such as a healthcare provider, to review the patient data prior to installing the patient-specific orthopedic implant in the patient.

NOVEL FIBRINOGEN-BASED BIOINKS FOR WOUND HEALING AND TISSUE REGENERATION

Resumen de: EP4631538A1

The present invention relates to a bioink formulation comprising fibrinogen and a glycosaminoglycans (GAGs)/collagen (Col) matrix, preferably comprising human cells, preferably human mesenchymal stem cells (hMSCs), keratinocytes and/or human dermal fibroblasts (hDFs), and its use in the treatment of tissue or bone injuries or damages, specifically skin tissue injuries or damages.

原位润滑3D打印Janus骨软骨修复支架及其制备方法

Resumen de: CN120771351A

本发明涉及一种原位润滑3D打印Janus骨软骨修复支架及其制备方法，其中，所述支架由3D打印制得，包括软骨下骨层及软骨层，其中：所述软骨下骨层由GelMA和NAGA负载nHA制得，以促进骨愈合；所述软骨层配置两性离子单体，实现原位润滑。本发明可通过软骨层支架结构润滑改性实现原位润滑，通过软骨下骨层支架负载羟基磷灰石促进骨愈合。

假肢打印方法、装置、电子设备、存储介质及计算机程序产品

Resumen de: CN120770988A

本申请公开了一种假肢打印方法、装置、电子设备、存储介质及计算机程序产品，其中，方法包括：获取第一用户的第一生理数据组；调用第一人工智能模型对第一生理数据组进行处理，得到第一约束参数组；第一人工智能模型用于基于输入的生理数据组推荐约束参数组；约束参数组表征该输入的生理数据组对应的机械性能要求相关的约束；以第一约束参数组作为约束，调用生成式设计算法对第一生理数据组进行处理，得到第一设计参数组；生成式设计算法用于基于输入的生理数据组生成满足对应的舒适度要求的设计参数组，且设计参数组中包含假肢的多个设计参数；基于第一设计参数组与切片参数组，生成第一文件，并输出第一文件至三维打印装置。

三维自组装支架

Resumen de: US2025313799A1

A three-dimensional scaffold includes a plurality of scaffold elements. Each scaffold element includes at least one peptide component, which comprises a stretch of amino acids, and at least two nucleic acid components. The at least two nucleic acid components of the plurality of scaffold elements are configured to mediate self-assembly of the three-dimensional scaffold.

一种牙齿3D打印机用可调式操作平台

Resumen de: CN223431997U

本实用新型涉及3D打印设备技术领域，提供了一种牙齿3D打印机用可调式操作平台，包括：安装板，驱动电机，通过架体设置在所述安装板的表面上；还包括：两个槽口，开设在所述安装板表面的对称处，其中一个所述槽口的内部设置有螺纹杆一，所述螺纹杆一的一端设置在驱动电机的输出端表面上。本实用新型，通过旋转滑槽内部的螺纹杆二，带动滑块在滑槽的内部进行移动，使得连接板表面的安装架进行横向移动，带动放置板对准打印机本体，通过驱动电机工作，带动输出端螺纹杆一表面的U型架沿着导向杆进行横向移动，使得打印的牙齿对准打印机本体的输出端，配合电动推杆工作，带动移动板表面的安装座进行纵向移动，完成打印机本体的打印工作。

3D 3D Printer-Based System for Manufacturing and Verifying Dental Orthodontic Appliances

Resumen de: KR102870460B1

본 발명은 3D 프린터를 활용한 치과 교정 장치 제조 및 검증 시스템에 있어서, 환자의 구강 내부를 3차원으로 스캔하여 디지털 구강 데이터를 생성하는 스캐닝부; 상기 디지털 구강 데이터를 기반으로 교정 장치의 3차원 모델을 생성하는 설계부; 상기 3차원 모델에 따라 수지 재질의 상기 교정 장치를 적층 제조하는 3D 프린팅부; 상기 3D 프린팅부로부터 출력된 상기 교정 장치의 형상 및 치수 정밀도를 검증하기 위하여, 출력된 상기 교정 장치의 표면을 3차원으로 스캔하는 검증 스캐닝부; 상기 검증 스캐닝부로부터 획득한 출력 형상 정보와 상기 설계부에서 생성된 3차원 모델 간의 차이를 정량적으로 분석하여, 허용 오차 범위를 초과하는 경우 재설계를 지시하는 정밀도 판별부를 포함하고, 상기 정밀도 판별부는, 상기 출력 형상 정보를 다점 클라우드 형식으로 분석하고, 상기 출력 형상 정보와 상기 설계부에서 생성된 3차원 모델 간의 차이로부터 오차 분포를 산출하며, 상기 오차 분포에 기초하여 보정 파라미터를 생성하고, 생성된 상기 보정 파라미터를 상기 설계부에 제공하여, 상기 설계부가 상기 보정 파라미터를 반영한 새로운 출력 모델을 생성하고, 상기 새로운 출력 모델이 상기 3D 프린팅부로 전송되어, 상기 3D 프린�

一种丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石及其制备方法和应用

Resumen de: CN120771340A

本发明公开了一种丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石(HAP@AM)及其制备方法和应用，涉及骨修复支架材料技术领域，所述丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石为表面接枝有甲基丙烯酰胺化阿仑膦酸钠的纳米羟基磷灰石；丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石中甲基丙烯酰胺化阿仑膦酸钠的接枝率为1～5wt％，丙烯酰胺化阿仑膦酸钠修饰羟基磷灰石的平均粒径为200～800nm，Zeta电位为‑12～‑22mV。本发明制备的HAP@AM在GelMA中具有优异的分散性与稳定性，与GelMA制成3D打印墨水，还具有优异的打印性能和力学性能。

3차원 광조형용 경화성 조성물 및 그 제조방법, 3차원 광조형물의 제조방법 및 치과용 수복물의 제조방법

Resumen de: AU2024218051A1

The present invention provides a curable composition for three-dimensional stereolithography, the curable composition being used in a vat photopolymerization method and containing 100 parts by mass of a polymerizable monomer component (A), 40 parts by mass to 400 parts by mass of an inorganic filler (B) that is composed of a single kind or plural kinds of inorganic particulate matter, and 0.01 part by mass to 5 parts by mass of a photopolymerization initiator (C), wherein: 80% or more of all primary particles that constitute the inorganic filler (B) have a particle diameter of 0.05 µm to 5.0 µm; and a sample, which is formed of this curable composition for three-dimensional stereolithography and has a thickness of 0.5 mm, has a transmittance of 1.00% to 50.00% with respect to activation light. The present invention also provides a method for producing this curable composition for three-dimensional stereolithography. The present invention also provides a method for producing a three-dimensional stereolithographic model and a method for producing a dental restoration, each using this curable composition for three-dimensional stereolithography.

PHANTOM BRAIN MODEL FORMING METHOD AND PHANTOM BRAIN MODEL

Resumen de: KR20250148068A

본 실시예는 팬텀 뇌 모델 형성 방법으로, 상기 방법은: 주입 전극을 형성하는 단계를 포함하고, 상기 주입 전극을 형성하는 단계는: 기판에 복수의 전극들 및 상기 전극들과 연결된 선로들을 형성하는 단계; 상기 복수의 전극들과 상기 선로들을 노출하는 봉지 패턴을 형성하는 단계; 노출된 상기 선로들과 외부 회로를 연결하는 외부 연결 선로를 전기적으로 연결하는 단계 및 상기 복수의 전극들을 외부로 노출하는 프로브 홀(probe hole)들을 포함하는 커버 부재를 형성하여 결합하는 단계를 포함한다.

情報処理装置、印刷装置、方法およびプログラム

Resumen de: JP2025155076A

【課題】服用者の薬の飲み忘れを防ぎ、且つ、複数ある服用タイミングのうち、特に注意すべき服用タイミングを服用者に認識させること。【解決手段】情報処理装置は、少なくとも１つのプロセッサを備える。少なくとも１つのプロセッサは、入力される複数の薬の服用情報に基づいて、複数の薬のうちの少なくとも１つを服用するタイミングである複数の服用タイミングのうち、所定の条件を満たす服用タイミングと、服用タイミングにおいて複数の薬のなかで服用すべき薬を服用者に認識させる情報である注意喚起情報と、を対応付け、対応付けられた注意喚起情報と服用タイミングとを出力装置に出力する。【選択図】図６

神経導管

Resumen de: CN120513057A

The invention relates to a nerve conduit for connecting an impaired nerve ending to a target site. In particular, the present invention relates to nerve conduits that support nerve injury repair and motion control and/or reduce the risk of development of injured nerve ending neuroma. Thus, a nerve conduit (10) connecting an impaired nerve ending (26) to a target site (28) is proposed, the nerve conduit (10) comprising an elongated body (12) formed by a wall (22) and comprising a central portion (14) defining a lumen (16) and end portions (18, 19) defining respective openings (20, 20 ') to the lumen (16), the end portions (18, 19) being arranged adjacent to the central portion (14) and located at longitudinally opposite ends of the elongated body (12). One tip portion (18) is configured as an insertion portion configured to be inserted into a corresponding nerve ending (26). According to the invention, the other end portion is configured as a nerve ending outlet portion (19) wherein the outer diameter of the wall defining the outlet portion (19) is greater than the outer diameter of the wall defining the central portion (14).

用于制备再生型植入体的激光增材制造系统

Resumen de: CN120772553A

本发明提供用于制备再生型植入体的激光增材制造系统，属于激光增材制备技术领域。该系统包括精细动态聚焦模块、成形模块、烟尘净化模块和风场调控模块；精细动态聚焦模块包括：光学聚焦单元，包括同轴设置的激光器、变倍扩束镜和振镜组件及场镜；水冷单元，其位于变倍扩束镜与振镜组件之间，包括水冷遮光孔板与外设的冷水机；动态变焦单元，通过驱动场镜位移形成混合变焦系统实现动态变焦；成形模块包括：成形缸；粉末床；加热器阵列，安装于成形缸内部侧壁与顶部并环绕粉末床的加热器阵列；温度传感器阵列，分布于粉末床上；风场调控模块在成形缸内部形成高温强迫环流。本发明解决了现有技术中再生型植入体激光增材制造的精细微孔制备难题。

Anthropomorphic breast phantom and method for making the same

Resumen de: KR20250148203A

실제 인체 유방 엑스선 영상과 유사한 영상을 제공할 수 있고, 유방 의인화 팬텀을 이용하여 AEC의 농도 조절인자를 최적화하여 자동노출 관전류량을 39.4%~43.4% 감소시킬 수 있는 유방 의인화 팬텀 및 그 제조방법이 개시된다. 상기 유방 의인화 팬텀 제조방법은 표준 엑스선 유방 DICOM(Digital Imaging and Communications in Medicine) 영상 파일을 디지털라이즈드 리서페인(digitalized lithophane) 기술을 이용하여 3D 프린팅을 위한 유방 의인화 팬텀의 3D 모델의 STL 파일을 만드는 STL파일 획득과정, 상기 STL 파일 형식의 상기 유방 의인화 팬텀 3D 모델을 슬라이싱하여 3D 프린터가 출력할 수 있도록 3D 프린터의 명령어인 G-code를 생성하는 G-code 생성과정 및 상기 G-code에 따라 상기 유방 의인화 팬텀 3D 모델을 3D 프린터로 출력하여 유방 의인화 팬텀 본체를 만드는 프린팅 과정을 포함하는 구성을 가진다.

Apparatus and Method of Producing Cartilage Soft Tissue Support and Cartilage Soft Tissue Support of Prepare by the same

Resumen de: KR20250145323A

본 발명은 유연한 생분해성 재질로 형성되어 연골을 지지할 수 있는 연골 연부조직 지지체 제조 장치 및 방법 및 이에 의해 제조된 연골 연부조직 지지체에 대한 것이며, 구체적으로 연골 연부조직 지지체 제조 장치에 있어서, 연골 연부조직 지지체의 패턴 및 형상을 3D 모델링으로 설계하는 설계부와 설계부와 연결되며, 성형재료를 공급하는 공급부와 공급부에 형성되며, 설계부에서 설계한 패턴 및 형상으로 이동함에 따라 성형재료를 출력하는 출력부와 출력부의 이동속도, 압력, 온도 중 선택된 하나를 제어하는 제어부를 구비한다.

3D Functional wrist protector with 3D printed pad to prevent and alleviate carpal tunnel syndrome

Resumen de: KR20250146085A

본 발명은 손목터널증후군 예방 및 완화를 위한 3D 프린팅 패드가 마련된 기능성 손목보호대에 관한 것으로서, 사용자의 손과 손목에 착용할 수 있도록 형성되어 있는 착용부와, 상기 착용부의 상부와 하부에 각각 형성되어 손목이 꺾이지 않은 상태로 지지될 수 있도록 하는 지지부를 포함하는 것을 특징으로 한다.

Methods for preparing porous scaffold for cell culture comprising marine-derived protein

Resumen de: KR20250146682A

본 발명은 (a) 해양 생물 유래 젤라틴과 알지네이트를 증류수에 녹여 젤라틴-알지네이트 혼합용액을 제조하는 단계; (b) 상기 젤라틴-알지네이트 혼합용액에 광개시제와 전자수용체를 첨가하여 전구체 용액을 준비하는 단계; (c) 상기 전구체 용액의 광가교를 유도하여 하이드로젤을 형성하는 단계; (d) 상기 하이드로젤의 이온결합을 유도하여 이중 가교 구조체를 형성하는 단계; 및 (e) 상기 이중 가교 구조체를 유기산 용액에 침지시켜 알지네이트를 제거함으로써 하이드로젤 다공성 구조체를 형성하는 단계;를 포함하는 3D 다공성 세포 지지체의 제조방법에 관한 것이다. 이에 의하여, 본 발명의 해양 생물 유래 단백질을 이용한 3D 다공성 세포 지지체의 제조방법은 근육세포와 유사한 형태로 세포배양이 이루어질 수 있을 뿐 아니라 세포의 부착이 용이하고 증식이 균일하게 이루어져 3차원으로 세포 배양을 매우 효율적으로 수행할 수 있으며, 해양 생물을 식재료로 이용할 때 발생하는 생선 비늘, 생선 껍질 등의 폐기물로부터 제조되는 젤라틴 재료를 활용하여 환경오염을 줄이고 비용도 절감할 수 있다.

METHOD FOR PRODUCING A DENTAL RESTORATION

Resumen de: KR20240080147A

The present invention relates to a method for manufacturing a dental restoration, comprising the steps of: (s101) determining a first space area of a dental restoration subject to a higher load than a second space area of the dental restoration; and (s102) manufacturing the dental restoration in the first space area with a different manufacturing material from the second space area.

SYSTEMS AND METHODS FOR OPTIMIZED PATIENT SPECIFIC TISSUE ENGINEERING VASCULAR GRAFTS

Resumen de: US2025009937A1

It has been established that optimizing cell seeding onto tissue engineering vascular grafts (TEVG) is associated with reduced inflammatory responses and reduced post-operative stenosis of TEVG. Cell seeding increased TEVG patency in a dose dependent manner, and TEVG patency improved when more cells were seeded, however duration of incubation time showed minimal effect on TEVG patency. Methods of engineering patient specific TEVG including optimal numbers of cells to maintain graft patency and reduce post-operative stenosis are provided. Closed, single-use customizable systems for seeding TEVG are also provided. Preferably the systems are custom-designed based on morphology of the patient specific graft, to enhance the efficacy of cell seeding.

一种距下关节固定装置

Resumen de: CN223416347U

本实用新型提供了一种距下关节固定装置，属于医疗器械技术领域。该距下关节固定装置包括足托，足托套设在穿戴者的足跟部；足托包括底板以及设置在底板两侧顶端的第一侧板与第二侧板，第一侧板与第二侧板相对向内折弯，第一侧板与第二侧板顶端分别向底板方向凹陷形成有凹槽；第一侧板与第二侧板与穿戴者的脚踝相贴合。该距下关节固定装置结构简单，适应性好，能充分开放前足活动空间，减少穿戴不适感，达到用户自我锻炼重塑肌肉韧带及行走发力问题，安全性高。

一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用

Resumen de: CN120757748A

本发明提供了一种带有螺硫吡喃基团的聚氨酯丙烯酸酯及其合成方法和应用，涉及义齿基托材料技术领域。带有螺硫吡喃基团的聚氨酯丙烯酸酯中将螺硫吡喃的C‑S弱共价键引入聚氨酯丙烯酸酯主链中，利用其在外力作用下易发生均裂的特性来耗散能量，并通过自由基介导的点击反应实现链间交联，从而增强机械强度，使其适用于义齿基托、口腔修复体、生物医学植入物等领域。

의료용 조직 랩

Resumen de: AU2023370241A1

The invention relates to the field of medical tissue wraps for internal anatomical structures as well as a use and a method of treating a nerve lesion using such medical tissue wraps. In particular, the invention relates to medical tissue wraps for neural tissue supporting the repair of peripheral nerve lesions by facilitating secure application of the medical tissue wrap. Accordingly, a medical tissue wrap (10) for an internal anatomical structure of a mammal is suggested, wherein the medical tissue wrap (10) is formed by a coiled wall (12) having a circumferential inner end portion (20) and a circumferential outer end portion (22) extending around and overlapping the circumferential inner end portion (20). The wall (12) thereby defines a longitudinal through-hole (16) for accommodating a portion of the anatomical structure. According to one aspect of the invention, the circumferential outer end portion (22) is radially spaced-apart from the circumferential inner end portion (20) by a discontinuous spacing in the circumferential direction. According to a further aspect, the tissue wrap comprises a structural outer surface modification at opposing longitudinal end portions of its wall.

一种仿生灯笼框架复合内固定装置及制备方法

Resumen de: CN120753772A

本发明公开了一种仿生灯笼框架复合内固定装置及制备方法，涉及骨科医疗器械技术领域，包括植入体和多棒桥接结构，多棒桥接结构由多个纵向连接棒与横向锁定钉组成，植入体由多个多层级仿生结构组成，多层级仿生结构包括两个对称设置的六边形上下层结构以及设置在两个六边形上下层结构之间的中间螺旋层结构。本发明从蜂窝与耗牛角宏微观结构中受到启发，采用耦合仿生技术制备出的多层级仿生结构具有优异的力学性能，缓冲吸振能力强，可有效匹配天然骨力学性能，可有效避免患者植入后二次损伤和“应力屏蔽”效应，通过电化学沉积方法引入的复合涂层弥补了单一植入体结构生物相容性不足、抗菌性不足、成骨分化能力弱的问题。

功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法

Resumen de: CN120754319A

本发明属于生物材料与组织工程技术领域，涉及一种功能化丝素蛋白基生物墨水、仿生软骨水凝胶及其制法。该墨水含有引发剂、SFMA、GelMA、PEGDA和OBC，各组分的配比严格控制；将该墨水与干细胞混合均匀后，引发固化交联反应，制成多重仿生软骨水凝胶。该水凝胶包括多重网络结构水凝胶以及同时分散在多重网络结构水凝胶中的OBC及干细胞，具有和真实软骨组织匹配的压缩模量以及多孔结构。本发明提供的功能化丝素蛋白基生物墨水及多重仿生软骨水凝胶，解决了现有技术中供体不足、免疫排斥、仿生维度单一、力学性能不匹配等问题，能实现高精度打印并高效促进软骨再生。

3D DRUG AUTO SYNTHSIZING MODULE AND MANUFACTURING USING 3D PRINTING THE SAME

Resumen de: KR20250144316A

본 발명은 의약품 자동합성 모듈 및 3D 프린팅을 이용한 의약품 자동합성 모듈 제조방법에 관한 것으로, 본 발명의 일 측면에 따르면 의약품 자동합성 모듈은 지르코니아 소재로 이루어지고, 메인 유로 및 상기 메인 유로와 연결된 복수의 연결 유로를 포함하는 합성모듈 바디, 상기 합성모듈 바디에 삽입되도록 구성되고, 상기 복수의 연결 유로를 개폐하도록 구성된 밸브 조립체, 상기 벨브 조립체와 상기 합성모듈 바디 사이를 실링하는 제1 탄성링을 포함한다.

一种运用3D打印技术制作可降解的乳房植入物的方法

Nº publicación: CN120756090A 10/10/2025

Solicitante:

深圳博瑞捷生物科技有限公司

Resumen de: CN120756090A

本申请提供了一种运用3D打印技术制作可降解的乳房植入物的方法，包括以下步骤：在3D打印喷头的加热腔内灌注打印材料；对加热腔加热至温度到达预设温度时3D打印设备开始打印工作，包括打印喷头的喷嘴挤出打印材料，并按预设程序在打印平台上方移动，保持加热腔温度稳定在预设温度；预设程序包括打印路径以预设图形的中心为起点，沿径向从内向外逐层打印，完成预设图形最后一层时打印工作结束；停止对加热腔的加热。通过加热腔稳定持续的加热，材料分子量逐渐减小，结合3D打印方法自预设图形由内向外逐层打印，使得乳房植入物的分子量自中心向外层逐层减小，解决了现有手段制作的乳房植入物的降解方向与细胞再生进程无法动态协同的问题。