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PHARMACEUTICAL COMBINATION FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

NºPublicación:  WO2026185106A1 10/09/2026
Solicitante: 
FOND DI RELIGIONE E DI CULTO CASA SOLLIEVO DELLA SOFFERENZA OPERA DI SAN PIO DA PIETRELCINA [IT]
FONDAZIONE DI RELIGIONE E DI CULTO \"CASA SOLLIEVO DELLA SOFFERENZA\" - OPERA DI SAN PIO DA PIETRELCINA
WO_2026185106_A1

Resumen de: WO2026185106A1

The present invention relates to the use of a pharmaceutical combination comprising molecules that rebilance the pathway of the epigenetic modulators LiN28, EZH2 and Let-7 and increases the expression of GFAP protein in particular in the treatment of all the diseases of the central nervous system (CNS) wherein LiN28, EZH2 and Let-7 dysregulation influence the expression of GFAP gene, selected from Huntington's disease, Amyotrophic Lateral Sclerosis (ALS), Schizophrenia, Bipolar Disorder, Fetal alcohol spectrum disorder and Autism. The invention further relates to the use of a pharmaceutical composition comprising said combination and at least one pharmaceutical acceptable excipient in the treatment and/or prevention of neurodegenerative diseases and neurodevelopment diseases.

DELAYED TIMED RELEASE PHARMACEUTICAL COMPOSITION, PREPARATION METHOD THEREFOR, AND USE THEREOF

NºPublicación:  US20260263349A1 10/09/2026
Solicitante: 
SHANGHAI WD PHARMACEUTICAL CO LTD [CN]
SHANGHAI WD PHARMACEUTICAL CO., LTD
US_20260263349_A1

Resumen de: US20260263349A1

A delayed timed release pharmaceutical composition, a preparation method therefor, and use thereof. The pharmaceutical composition comprises a tablet core. The tablet core comprises a drug-containing layer and a boosting layer stacked on the drug-containing layer. The drug-containing layer comprises a drug active ingredient. The drug active ingredient is levodopa or a derivative thereof, or a mixture of levodopa or a derivative thereof and a DOPA decarboxylase inhibitor, and accounts for 5-72.5 wt % of the content of the drug-containing layer. The pharmaceutical composition is a capsule-shaped tablet, can realize the effects of 1-3 h delayed release of the drug active ingredient and reaching a peak concentration at 6-10 h, can be used for reducing morning stiffness in patients with Parkinson's disease, and has good application prospects.

PEPTIDE FOR TREATMENT OF COGNITIVE DISEASES

NºPublicación:  AU2025231257A1 10/09/2026
Solicitante: 
PRIAVOID GMBH
PRIAVOID GMBH
AU_2025231257_PA

Resumen de: AU2025231257A1

The present invention relates to peptides for treatment of cognitive diseases, in particular Alzeheimer's Disease, mild cognitive impairment due to Alzheimer's disease, and mild dementia due to Alzheimer's disease.

DELIVERY OF TAU REPRESSORS USING THE BLOOD-BRAIN BARRIER PENETRANT CAPSID

NºPublicación:  AU2025234423A1 10/09/2026
Solicitante: 
SANGAMO THERAPEUTICS INC
SANGAMO THERAPEUTICS, INC.
AU_2025234423_PA

Resumen de: AU2025234423A1

Provided are compositions for delivery of zinc finger fusion proteins that inhibit expression of tau in the nervous system using the blood-brain barrier penetrant AAV capsid proteins comprising SEQ ID. NO: 1235, and methods of using the compositions to treat neurodegenerative diseases such as Alzheimer's disease, frontotemporal dementia, and other tauopathies.

PYRAZOLO3,4-DPYRIMIDIN-6-YL-SULFONAMIDE DERIVATIVES FOR THE INHIBITION OF SGK-1

NºPublicación:  US20260265261A1 10/09/2026
Solicitante: 
THRYV THERAPEUTICS INC [CA]
THRYV THERAPEUTICS INC.
US_20260265261_A1

Resumen de: US20260265261A1

Compounds of Formula I:and pharmaceutically acceptable salts thereof are provided for as inhibitors of SGK-1 for example for the treatment of conditions such as Long QT syndrome, heart failure, arrhythmia, ischemic injury, ischemic infarction, cardiac fibrosis, vascular proliferation, restenosis, dilated cardiomyopathy, stent failure, prostate cancer, epilepsy, colorectal cancer, breast cancer, Parkinson's disease and Lafora disease.

AMPHIPHILIC NANOPARTICLES TO TARGET AMYLOID BETA-INDUCED MICROGLIAL ACTIVATION

NºPublicación:  US20260263373A1 10/09/2026
Solicitante: 
RUTGERS THE STATE UNIV OF NEW JERSEY [US]
THE REGENTS OF THE UNIV OF CALIFORNIA [US]
Rutgers, The State University of New Jersey
The Regents of the University of California
US_20260263373_A1

Resumen de: US20260263373A1

Nanoparticle compositions and methods inhibiting amyloid beta (Aβ) fibrilization in a subject in need thereof using nanoparticles to target fibril β-amyloid (fAβ)-specific scavenger receptors. Also provided is a method of using nanoparticle compositions to treat Alzheimer's disease (AD) and similar amyloidopathies.

MAGNETOGENETIC SYSTEM BASED ON CLMAGR GENE AND USE THEREOF IN PARKINSON'S DISEASE

NºPublicación:  WO2026184543A1 10/09/2026
Solicitante: 
SOUTHEAST UNIV [CN]
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WO_2026184543_A1

Resumen de: WO2026184543A1

Provided are a magnetogenetic system based on a clMagR gene and a use thereof in Parkinson's disease. The clMagR gene is injected into neurons by means of an adeno-associated virus (AAV) vector, and on the basis of exogenous iron and magnetic field stimulation technology, a biological function of cells or tissues is regulated. Compared with optogenetics, the system avoids optical fiber implantation and direct light source irradiation required for optogenetics by means of precise control of an external magnetic field, reduces the risk of invasive surgery, and can more widely regulate cell functions in deep neural regions in the body, especially in deep brain regions. Compared with traditional treatment methods, the present invention provides a non-invasive and regulatable gene therapy strategy, providing a new technical paradigm for fields such as stem cell therapy, nerve regeneration, drug delivery, and elucidation of the neural circuit mechanism of diseases.

METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING NEURODEGENERATIVE AND/OR AGE-RELATED DISEASES

NºPublicación:  WO2026185857A1 10/09/2026
Solicitante: 
LEUMIT LAATID LTD [IL]
LEUMIT LAATID LTD
WO_2026185857_A1

Resumen de: WO2026185857A1

A method for preventing and/or treating a disease or disorder selected from the group consisting of neurodegenerative disease, hepatic or renal disease, pulmonary disease, cardiovascular disease, cerebrovascular disease, metabolic disease, diabetes mellitus, substance use disorder (SUD), solid tumor, and any combination thereof, by administering a therapeutically effective amount of at least one anti-protozoal compound, e.g., anti-malarial and/or anti-toxoplasma compound, potentially targeting Plasmodium and/or Toxoplasma gondii. The composition may include atovaquone, proguanil, or a combination thereof with possible adjunctive therapies. Further provided are methods and kits for diagnosing Alzheimer's disease or determining an increased risk of developing Alzheimer's disease in a subject.

PYRAZOLO-PYRIDO-OXAZINE DERIVATIVES FOR THE TREATMENT OF ABNORMALITIES ASSOCIATED WITH TAU PROTEIN AGGREGATES

NºPublicación:  WO2026185478A1 10/09/2026
Solicitante: 
AC IMMUNE SA [CH]
AC IMMUNE SA
WO_2026185478_A1

Resumen de: WO2026185478A1

The present invention relates to compounds of formula (I) that can be employed in the treatment, alleviation or prevention of a group of diseases, disorders and or abnormality associated with Tau protein aggregates, including, but not limited to, Alzheimer's disease (AD). The present invention also relates to, pharmaceutical compositions comprising said compounds, methods using said compounds, combinations comprising said compounds, medicaments containing them, and their uses in diseases, disorders and/or abnormalities associated with Tau protein aggregates.

METHODS OF TREATMENT AND DIAGNOSIS USING ANTI-ACETYLATED TAU ANTIBODIES

NºPublicación:  WO2026187868A1 10/09/2026
Solicitante: 
AETON THERAPEUTICS INC [US]
AETON THERAPEUTICS, INC.
WO_2026187868_A1

Resumen de: WO2026187868A1

The present disclosure provides specific anti-ac-tauK174, anti-ac-tauK274, and ac-tauK353 antibodies, or antigen-binding fragments thereof, and methods of their use in diagnosing, differentiating, targeting, staging, prognosing, and/or treating Alzheimer's Disease and related tauopathies, including traumatic brain injury. Methods of identifying a subject having early Alzheimer's Disease and related tauopathies are also provided, the methods comprising detecting proteins using at least one anti-ac-tauK174 antibody, at least one anti-ac-tauK274 antibody, and/or at least one anti-ac-tauK353 antibody. In some embodiments, the subject is ApoE4-positive.

POTENT, SELECTIVE CPLA2 INHIBITORS FOR TARGETING NEUROINFLAMMATION IN ALZHEIMER'S DISEASE AND OTHER NEURODEGENERATIVE DISORDERS

NºPublicación:  WO2026187862A1 10/09/2026
Solicitante: 
UNIV OF SOUTHERN CALIFORNIA [US]
UNIVERSITY OF SOUTHERN CALIFORNIA
WO_2026187862_A1

Resumen de: WO2026187862A1

Disclosed herein are compounds of the formula: (I), as well as pharmaceutical compositions thereof, wherein the variables are defined herein. In some aspects, the compounds and compositions provided herein may be used to treat neurodegenerative disorders, such as Alzheimer's disease. Also provided are methods of administering compounds and compositions provided herein to a patient in need thereof.

VANILLIC ACID DERIVATIVE COMPOUND, THERAPEUTIC AGENT COMPOSITION FOR ALZHEIMER'S DISEASE COMPRISING SAME, AND THERAPEUTIC AGENT COMPOSITION FOR NEUROINFLAMMATORY DISEASE

NºPublicación:  WO2026187186A1 10/09/2026
Solicitante: 
THERANOCURE CO LTD [KR]
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WO_2026187186_A1

Resumen de: WO2026187186A1

The present invention relates to a vanillic acid derivative compound that can be formed by a dehydration condensation reaction between vanillic acid and catecholamine. The vanillic acid derivative compound according to the present invention can be used as a therapeutic agent for Alzheimer's disease and neuroinflammation. In addition, the present invention relates to a therapeutic agent composition for Alzheimer's disease and a therapeutic agent composition for neuroinflammation, each comprising the compound.

INFLAMMASOME ANTIBODY COMPOSITION AND METHOD FOR TREATING NEUROLOGIC DISORDER

NºPublicación:  WO2026188223A1 10/09/2026
Solicitante: 
UNIV OF MIAMI [US]
UNIVERSITY OF MIAMI
WO_2026188223_A1

Resumen de: WO2026188223A1

The compositions and methods described herein include methods and agents that inhibit inflammasome signaling in a mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s) or other agents. Also described herein are compositions and methods of use thereof for detecting and treating early-stage Alzheimer's disease as well as other inflammatory neurologic conditions such as Huntington's Disease.

COMPOUNDS FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

NºPublicación:  WO2026183787A1 10/09/2026
Solicitante: 
CHANG GUNG MEMORIAL HOSPITAL LINKOU [CN]
CHANG GUNG MEMORIAL HOSPITAL, LINKOU
WO_2026183787_A1

Resumen de: WO2026183787A1

Provided is a compound or a pharmaceutically acceptable salt, hydrate or solvate thereof for use in the treatment of amyotrophic lateral sclerosis represented by the following Formula (I). Also provided is a pharmaceutical composition comprising the above compound or a pharmaceutically acceptable salt, hydrate or solvate thereof for use in the treatment of amyotrophic lateral sclerosis.

METHODS AND COMPOSITIONS FOR INHIBITING NEUROINFLAMMATION

NºPublicación:  WO2026188235A1 10/09/2026
Solicitante: 
MEMORIAL SLOAN KETTERING CANCER CENTER [US]
SLOAN KETTERING INST FOR CANCER RESEARCH [US]
MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES [US]
MEMORIAL SLOAN-KETTERING CANCER CENTER
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH
MEMORIAL HOSPITAL FOR CANCER AND ALLIED DISEASES
WO_2026188235_A1

Resumen de: WO2026188235A1

The present disclosure relates to methods of preventing and/or treating neuroinflammation in a subject in need thereof. The present disclosure also relates to methods and systems for modeling aging related neurodegenerative diseases (e.g., Amyotrophic lateral sclerosis (ALS)) in vitro. The methods comprise administering one or more Angiotensin II Receptor I Blocker (ARB) to the subject. The present disclosure also relates to methods and systems for modeling aging related neurodegenerative diseases (e.g., ALS) in vitro.

METHODS OF TREATING PARKINSON'S DISEASE WITH T-TYPE CALCIUM CHANNEL MODULATORS

NºPublicación:  AU2025232421A1 10/09/2026
Solicitante: 
PRAXIS PRECISION MEDICINES INC
PRAXIS PRECISION MEDICINES, INC.
AU_2025232421_PA

Resumen de: AU2025232421A1

Described herein, in part, are methods useful for preventing and/or treating a disease or condition relating to aberrant function or activity of a T-type calcium channel, such as Parkinson's disease, psychiatric disorders (e.g., mood disorder (e.g., major depressive disorder)), pain, tremor (e.g., essential tremor), seizures (e.g., absence seizures), epilepsy, or an epilepsy syndrome (e.g., juvenile myoclonic epilepsy). The present invention further comprises methods for modulating the function of a T-type calcium channel and methods of administering a titrated dosage of a T-type calcium channel antagonist.

PROTOCOL FOR GENERATING NEURAL PROGENITOR CELLS AND IMPLEMENTATIONS THEREOF

NºPublicación:  US20260263525A1 10/09/2026
Solicitante: 
EYESTEM RES PRIVATE LIMITED [IN]
Eyestem Research Private Limited
US_20260263525_A1

Resumen de: US20260263525A1

A cell culture protocol for obtaining neural progenitor cells from induced pluripotent stem cells is described. Also described are a pharmaceutical composition and a medicament containing the neural progenitor stem cells for use in the treatment of neuro degenerative disorders such as Parkinson's disease as described.

PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING ALZHEIMER’S DISEASE, COMPRISING, AS ACTIVE INGREDIENT, LACTIC ACID BACTERIA FERMENTATION SOLUTION OF MORI FRUCTUS EXTRACT

NºPublicación:  US20260256865A1 03/09/2026
Solicitante: 
DONGGUK UNIV WISE CAMPUS INDUSTRY ACADEMY COOPERATION FOUNDATION [KR]
DONGGUK UNIV INDUSTRY ACADEMY COOPERATION FOUNDATION [KR]
DONGGUK UNIVERSITY WISE CAMPUS INDUSTRY-ACADEMY COOPERATION FOUNDATION
DONGGUK UNIVERSITY INDUSTRY-ACADEMY COOPERATION FOUNDATION
US_20260256865_A1

Resumen de: US20260256865A1

The present invention relates to a pharmaceutical composition for preventing or treating Alzheimer's disease, comprising, as an active ingredient, a mulberry fruit extract fermented with lactic acid bacteria. The mulberry fruit extract fermented with lactic acid bacteria improves memory and cognitive function, and thus can exhibit excellent effects on preventing, alleviating or treating Alzheimer's disease.

AMINOTHIAZOLE COMPOUND AND USE THEREOF AS BRAIN-PERMEABLE HISTAMINE H2 RECEPTOR AGONIST

NºPublicación:  WO2026179739A1 03/09/2026
Solicitante: 
ZHEJIANG UNIV [CN]
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WO_2026179739_A1

Resumen de: WO2026179739A1

Disclosed in the present invention are an aminothiazole compound and use thereof as a brain-permeable histamine H2 receptor agonist, which belong to the field of medicine. The aminothiazole compound provided in the present invention has a general structural formula represented by formula (I) and comprises a pharmaceutically acceptable salt. The aminothiazole compound of the present invention has histamine H2 receptor agonist activity and excellent blood-brain barrier permeability. Therefore, the aminothiazole compound can be used in the preparation of a medicament for treating schizophrenia, mania, attention deficit hyperactivity disorder, binge eating disorder or bulimia nervosa, autism, Parkinson's disease, ischemic brain injury, and other diseases.

USE OF CAMKII PEPTIDE INHIBITORS IN NEUROLOGICAL DISEASE

NºPublicación:  WO2026183114A2 03/09/2026
Solicitante: 
THE REGENTS OF THE UNIV OF COLORADO A BODY CORPORATE [US]
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
WO_2026183114_A2

Resumen de: WO2026183114A2

The present disclosure provides, among other things, methods for restoring neuronal function in a subject in need thereof, methods for treating a subject with Alzheimer's Disease (AD) or a subject that has suffered from an acute central nervous system (CNS) injury, and methods for improving one or more brain functions in a subject in need thereof. Such methods can comprise administering to the subject one or more peptide inhibitors of Ca2+/calmodulin-dependent protein kinase II (CaMKII).

TRADITIONAL CHINESE MEDICINE COMPOSITION FOR TREATING AMYOTROPHIC LATERAL SCLEROSIS AND USE THEREOF

NºPublicación:  US20260256860A1 03/09/2026
Solicitante: 
HEBEI YILING MEDICAL RESEARCH INST CO LTD [CN]
HEBEI YILING MEDICAL RESEARCH INSTITUTE CO., LTD
US_20260256860_A1

Resumen de: US20260256860A1

A traditional Chinese medicine composition for treating amyotrophic lateral sclerosis and the use thereof. The composition is prepared by means of combining Ginseng radix et rhizoma and Cistanches herba.

CAMKII PEPTIDE INHIBITORS AND USE IN NEUROLOGICAL DISEASE

NºPublicación:  WO2026183116A2 03/09/2026
Solicitante: 
THE REGENTS OF THE UNIV OF COLORADO A BODY CORPORATE [US]
THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
WO_2026183116_A2

Resumen de: WO2026183116A2

The present disclosure provides, among other things, methods for restoring neuronal cell function in a subject having a brain-related disorder and methods for improving one or more brain functions in a subject with Alzheimer's Disease (AD) or a subject that has suffered from an acute central nervous system (CNS) injury. Such methods can comprise administering to the subject one or more peptide inhibitors of Ca2+/calmodulin-dependent protein kinase II (CaMKII). The present disclosure also provides a composition comprising one or more peptide inhibitors of Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII inhibitor peptides).

TARGETING LYSOSOMAL LIPID IN ALZHEIMER'S DISEASE

NºPublicación:  US20260256960A1 03/09/2026
Solicitante: 
THE UNIV OF NORTH CAROLINA AT CHAPEL HILL [US]
The University of North Carolina at Chapel Hill
US_20260256960_A1

Resumen de: US20260256960A1

Novel lysosomal acid lipase (LAL) positron emission tomography ligands are provided. Also disclosed herein are methods of assessing the risk of developing Alzheimer's disease (AD) or Alzheimer's Disease Related Dementias (ADRD) and methods of diagnosing AD/ADRD in a subject comprising measuring levels of LAL and optionally LAL accumulation in the subject. Methods of treatment comprising administering LAL are also provided.

Pharmaceutical formulations comprising a cyclodextrin

NºPublicación:  US20260256889A1 03/09/2026
Solicitante: 
NOVO NORDISK AS [DK]
Novo Nordisk A/S
US_20260256889_A1

Resumen de: US20260256889A1

0000 Disclosed herein is a liquid pharmaceutical formulation comprising an amylin receptor agonist, a GLP-1 receptor agonist and a cyclodextrin comprising hydroxypropyl substitutions. Said co-formulation may be used for the medical treatment of subjects with overweight or obesity, with or without associated co-morbidities; diabetes, with or without associated comorbidities; cardiovascular diseases, non-alcoholic steatohepatitis (NASH) and cognitive impairment, such as that caused by Alzheimer's disease.

NFL530 PEPTIDE RATIOS AS BIOMARKERS IN NEUROLOGICAL CONDITIONS AND METHODS OF USE THEREOF

Nº publicación: WO2026183555A1 03/09/2026

Solicitante:

WASHINGTON UNIV [US]
WASHINGTON UNIVERSITY

WO_2026183555_A1

Resumen de: WO2026183555A1

Methods of treating a neurodegenerative disease in a subject in need thereof are provided. Exemplary methods include providing a biological sample from the subject; measuring an NfL530 peptide concentration in the biological sample; measuring at least one of an NfL284 peptide concentration and an NfL101 peptide concentration in the biological sample; determining at least one of an NfL530/NfL284 ratio and an NfL530/NfL101 ratio; and treating the subject based on the determined NfL530/NfL284 and/or NfL530/NfL101 ratio. In some embodiments, the biological sample is selected from whole blood, plasma, and cerebrospinal fluid. In some embodiments, the subject is determined to have ALS based on the determined NfL530/NfL284 and/or NfL530/NfL101 ratio.

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