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LastUpdate Última actualización 30/01/2026 [07:25:00]
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N-(1-(TERT-BUTYL)-1 H-PYRAZOL-4-YL)-2-(4-((6-(QUINOLIN-4-YL)OXY)-PHENYL)ACET AMIDE DERIVATIVES AS RIPK2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

NºPublicación:  WO2025250667A1 04/12/2025
Solicitante: 
ODYSSEY THERAPEUTICS INC [US]
ODYSSEY THERAPEUTICS, INC
WO_2025250667_PA

Resumen de: WO2025250667A1

The present disclosure relates to RIPK2 inhibitors of the formulae (I) or (II) for the treatment of e.g. inflammatory diseases, autoimmune diseases, granulomatous disease, neurodegenerative diseases or cancer, and, more specifically, for the treatment of inflammatory bowel disease, such as Crohn's disease or ulcerative colitis, rheumatoid arthritis, inflammatory arthritis, peritonitis, ischemia reperfusion injury in kidney transplant, non-alcohol steatohepatitis, alcohol steatohepatitis, insulin-resistant type 2 diabetes, allergic rhinitis, asthma, atopic dermatitis, Sjogren's syndrome, spondyloarthritis, ankylosing spondylitis, pemphigus vulgaris, idiopathic plasmacytic lymphadenopathy, atherosclerosis, myocardial infarction, thrombosis, alpha-synucleinopathy, Parkinson's disease, dementia with Lewy body, multiple system atrophy, Alzheimer's disease, amyotrophic lateral sclerosis, and chronic obstructive pulmonary disease.

CRYSTALLINE FORMS OF N-(1-(TERT-BUTYL)-1H-PYRAZOL-4-YL)-2-(4-((6-((METHYLSULFONYL)QUINOLIN-4-YL)OXY)-3-METHYLPHENYL)ACETAMIDE AND SALTS THEREOF AS RIPK2 INHIBITORS FOR THE TREATMENT OF INFLAMMATORY DISEASES

NºPublicación:  WO2025250650A1 04/12/2025
Solicitante: 
ODYSSEY THERAPEUTICS INC [US]
ODYSSEY THERAPEUTICS, INC
WO_2025250650_PA

Resumen de: WO2025250650A1

The present disclosure relates to crystalline forms of N-(l-(tert-butyl)-lH-pyrazol-4-yl)-2-( 4-((6-((methylsulfonyl)quinolin-4-yl)oxy)-3-methylphenyl)acetamide of formula (II) and crystalline forms of salts thereof. The compound of formula (II) is a RIPK2 inhibitor for the treatment of e.g. inflammatory diseases, autoimmune diseases, granulomatous disease, neurodegenerative diseases or cancer, and more specifically for the treatment of inflammatory bowel disease, such as Crohn's disease or ulcerative colitis, rheumatoid arthritis, inflammatory arthritis, peritonitis, ischemia reperfusion injury in kidney transplant, non-alcohol steatohepatitis, alcohol steatohepatitis, insulin-resistant type 2 diabetes, allergic rhinitis, asthma, atopic dermatitis, Sjogren's syndrome, spondyloarthritis, ankylosing spondylitis, pemphigus vulgaris, idiopathic plasmacytic lymphadenopathy, atherosclerosis, myocardial infarction, thrombosis, alpha-synucleinopathy, Parkinson's disease, dementia with Lewy body, multiple system atrophy, Alzheimer's disease, amyotrophic lateral sclerosis, and chronic obstructive pulmonary disease

PULSATILE DRUG DELIVERY SYSTEM FOR TREATING MORNING AKINESIA

NºPublicación:  US2025367123A1 04/12/2025
Solicitante: 
CONTERA PHARMA AS [DK]
CONTERA PHARMA A/S
US_2025367123_A1

Resumen de: US2025367123A1

Provided herewith is a pharmaceutical composition comprising, separately or together, a pulsatile release component comprising levodopa and a DOPA decarboxylase inhibitor for the management of OFF-time episodes in patients with Parkinson's disease.

Aav treatment of huntington's disease

NºPublicación:  IL323940A 01/12/2025
Solicitante: 
UNIV OF MASSACHUSETTS [US]
UNIVERSITY OF MASSACHUSETTS
IL_323940_A

Resumen de: ZA201902226B

Aspects of the disclosure relate to compositions and methods useful for treating Huntington' s disease. In some embodiments, the disclosure provides interfering nucleic acids (e.g., artificial miRNAs) targeting the huntingtin gene (HTT) and methods of treating Huntington's disease using the same.

SCYLLO-INOSITOL IN COMBINATION WITH IMMUNOTHERAPEUTICS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

NºPublicación:  MX2025002727A 01/12/2025
Solicitante: 
EIRGEN PHARMA LTD [IE]
EIRGEN PHARMA, LTD
CN_120826223_PA

Resumen de: MX2025002727A

The disclosure relates to a combination of active ingredients/adjuvants for the treatment of neurological disorders and diseases such as Alzheimer's disease and mild cognitive impairment (MCI) and memory and cognitive disorders and conditions. In particular, combinations of scyllo-inositol and treatments for Alzheimer's disease such as lecanemab are disclosed as useful.

PREVENTIVE OR THERAPEUTIC AGENT FOR NEURODEGENERATIVE DISEASE

NºPublicación:  MX2025013089A 01/12/2025
Solicitante: 
MEDILABO RFP INC [JP]
UNIV PUBLIC CORPORATION OSAKA [JP]
MEDILABO RFP, INC,
UNIVERSITY PUBLIC CORPORATION OSAKA
WO_2024228392_PA

Resumen de: MX2025013089A

The purpose of the present invention is to provide a drug that exhibits the effect of inhibiting aggregation of a causative protein of an HRE-related neurodegenerative disease such as ALS. According to the present invention, rifampicin or a related substance selected from the group consisting of rifampicin, a derivative thereof, and salts thereof, and/or resveratrol or a related substance selected from the group consisting of resveratrol and a derivative thereof is an active ingredient of a preventive or therapeutic agent for a neurodegenerative disease caused by TDP-43 accumulation, or an active ingredient of a preventive or therapeutic agent for ALS.

TREATMENT OF PARKINSON'S DISEASE IN A PATIENT USING A GLUCOCEREBROSIDASE ACTIVATOR

NºPublicación:  MX2025010647A 01/12/2025
Solicitante: 
BIAL R&D INVEST S A [PT]
BIAL - R&D INVESTMENTS, S.A
AU_2024237252_A1

Resumen de: MX2025010647A

Methods for preventing, limiting or delaying clinical motor progression in a subject with Parkinson's disease with low GCase activity, such as a PD patient with a pathogenic variant in the glucocerebrosidase 1 (GBA1) gene (GBA-PD) is provided, said methods comprising administering a therapeutically effective amount of 5,7-dimethyl-N-((1R,4R)-4- (pentyloxy)cyclohexyl)pyrazolol1,5-apyrimidine-3-carboxamide (Compound A), or a pharmaceutically acceptable salt thereof, to said subject.

RNAI AGENTS FOR INHIBITING EXPRESSION OF ATAXIN-2 (ATXN2), COMPOSITIONS THEREOF, AND METHODS OF USE

NºPublicación:  MX2025010867A 01/12/2025
Solicitante: 
ARROWHEAD PHARMACEUTICALS INC [US]
ARROWHEAD PHARMACEUTICALS, INC
AU_2024240456_A1

Resumen de: MX2025010867A

Described are RNAi agents, compositions that include RNAi agents, and methods for inhibition of a Ataxin-2 (ATXN2) gene. The ATXN2 RNAi agents and RNAi agent conjugates disclosed herein inhibit the expression of an ATXN2 gene. Pharmaceutical compositions that include one or more ATXN2 RNAi agents, optionally with one or more additional therapeutics, are also described. Delivery of the described ATXN2 RNAi agents to central nervous system (CNS) tissue, in vivo, provides for inhibition of ATXN2 gene expression and a reduction in ATXN2 activity, which can provide a therapeutic benefit to subjects, including human subjects, for the treatment of various diseases including spinocerebellar ataxia type 2 (SCA2) or amyotrophic lateral sclerosis (ALS.)

VARIANT RNAi

Nº publicación: CA3255657A1 01/12/2025

Solicitante:

GENZYME CORP [US]
Genzyme Corporation

AU_2025205501_A1

Resumen de: CA3255657A1

Provided herein are RNAi molecules including a first strand containing a guide sequence and a second strand comprising a non-guide sequence where the non-guide sequence contains a bulge opposite the seed region of the guide sequences; e.g., opposite the cleavage sequence. In some aspects, the invention provides RNAi for treating Huntington's disease. Further provided herein are expression cassettes, vectors (e.g., rAAV, recombinant adenoviral, recombinant lentiviral, and recombinant HSV vectors), cells, viral particles, and pharmaceutical compositions containing the RNAi. Yet further provided herein are methods and kits related to the use of the RNAi, for example, to treat Huntington's disease.

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