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Biomarker combination based on mitochondrial oxidative stress for auxiliary diagnosis of dilated cardiomyopathy and application of biomarker combination

NºPublicación:  CN122303422A 30/06/2026
Solicitante: 
ZHONGSHAN HOSPITAL FUDAN UNIVESITY
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CN_122303422_A

Resumen de: CN122303422A

The invention relates to the field of biological medicine, and discloses a biomarker composition based on mitochondrial oxidative stress for auxiliary diagnosis of dilated cardiomyopathy and application of the biomarker composition. The biomarker combination comprises a TARS2 gene, a NOX4 gene and an SNCA gene. The biomarker combination can be applied to preparation of an auxiliary diagnosis kit for dilated cardiomyopathy, auxiliary diagnosis of dilated cardiomyopathy can be efficiently and accurately achieved by detecting the expression level of each gene in the biomarker combination, and compared with a traditional diagnosis means, the biomarker combination has the advantages that the sensitivity is high on the basis of mitochondrial oxidative stress related gene characteristics, and the sensitivity is high. The diagnosis accuracy is higher, and the applicability is better.

Method for predicting gestational hypertension in early pregnancy and application thereof

NºPublicación:  CN122314366A 30/06/2026
Solicitante: 
BGI GENOMICS CO LTD
SHIJIAZHUANG HUADA MEDICAL INSPECTION LABORATORY CO LTD
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CN_122314366_PA

Resumen de: CN122314366A

The invention relates to a group of genes related to gestational hypertension, a method for predicting gestational hypertension in early pregnancy by using the related genes and related application thereof. Specifically, a transcript starting site characteristic value of at least one of LOC124902572, EEF1A1P16, LOC105369767, GOLM2, CDRT7, MEIS3 and LOC105376108 in a to-be-detected pregnant woman cfDNA sample is obtained, and after the transcript starting site characteristic value is input into a prediction model, whether the risk of gestational hypertension exists or not is judged according to an output result. The initial site feature value of the transcript is the sequence number of the corrected transcriptional initial site region. The obtained prediction model can effectively and stably perform early prediction on the risk of gestational hypertension (including preeclampsia) in the early pregnancy so as to assist a doctor in performing early pregnancy intervention on a subject and reduce the occurrence risk of gestational hypertension.

Application of pulmonary vessel tsRNA in diagnosis and treatment of hypoxic pulmonary hypertension

NºPublicación:  CN122279030A 26/06/2026
Solicitante: 
FIRST PEOPLES HOSPITAL LIANYUNGANG
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CN_122279030_PA

Resumen de: CN122279030A

The invention discloses application of a reagent for detecting the expression level of pulmonary vessel tsRNA in preparation of a product for diagnosing and treating hypoxic pulmonary hypertension, the product and a pharmaceutical composition, and relates to the technical field of biomedicine, pulmonary vessel tsRNA is mt-tRF5-21-PheGAA, the nucleotide sequence of the mt-tRF5-21-PheGAA is GTTTATGTAGCTTACCTCCTC, the product comprises the reagent for detecting the expression level of tsRNA, and the reagent for detecting the expression level of tsRNA is applied to diagnosis and treatment of hypoxic pulmonary hypertension. The pharmaceutical composition comprises an activating agent of tsRNA, wherein the activating agent is an overexpression vector of mt-tRF5-21-PheGAA; according to the application of the pulmonary vessel tsRNA in diagnosis and treatment of the hypoxic pulmonary hypertension, the regulation effect of mt-tRF5-21-PheGAA on vascular remodeling caused by the pulmonary hypertension is defined, excessive proliferation of PASMCs is inhibited, pulmonary vascular remodeling and increase of the pulmonary hypertension are inhibited, and a new treatment target is provided for treatment of hypoxic PH through nucleic acid.

Mn-CeO2 (at) CDs nano-enzyme and Cas12a sensing-based miRNA multi-modal detection array, and preparation method and application of Mn-CeO2 (at) CDs nano-enzyme and Cas12a sensing-based miRNA multi-modal detection array

NºPublicación:  CN122278827A 26/06/2026
Solicitante: 
UNIV FUJIAN MEDICAL
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CN_122278827_PA

Resumen de: CN122278827A

The invention relates to the technical field of biological detection, in particular to a miRNA (micro Ribonucleic Acid) multi-modal detection array based on Mn-CeO2 (at) CDs nano enzyme and Cas12a sensing as well as a preparation method and application of the miRNA multi-modal detection array. The identification and signal amplification probe composition based on the Mn-CeO2 (at) CDs nano-enzyme and Cas12a comprises a solid-phase substrate, the DNA Y-type structure in the first aspect, the composite nano-enzyme and a CRISPR/Cas12a (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeats) system. According to the invention, a DNA nanotechnology and a Cas12a enzyme digestion technology are combined, and nanoenzyme is used as a signal output medium. And the high-specificity and high-sensitivity multi-mode detection of the myocarditis marker miRNA in three modes of fluorescence, ultraviolet-visualization and electrochemistry is realized.

BOB1-seRNA AND APPLICATION THEREOF

NºPublicación:  US20260174904A1 25/06/2026
Solicitante: 
TONGJI HOSPITAL AFFILIATED TO TONGJI MEDICAL COLLEGE OF HUAZHONG UNIV OF SCIENCE & TECHNOLOGY [CN]
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
US_20260174904_A1

Resumen de: US20260174904A1

0000 A B-cell specific octamer-binding protein 1 super-enhancer ribonucleic acid (BOB1-seRNA) and an application thereof are provided. The nucleotide sequence of the BOB1-seRNA is shown in SEQ ID NO: 1. Through experiments, it further confirms that the BOB1-seRNA is downregulated in patients with coronary heart disease and can be used in preparation of a product for diagnosing or predicting the coronary heart disease. The use of this molecular marker can be used for early diagnosis of the coronary heart disease, which is rapid and effective. It is not only of great significance for early treatment of the coronary heart disease and saving medical costs, but also provides therapeutic targets and important basis for clinical applications such as gene therapy and drug therapy.

TOXICITY MARKER FOR 5-FLUOROURACIL

NºPublicación:  US20260176700A1 25/06/2026
Solicitante: 
THE UNIVERSTIY OF BIRMINGHAM [GB]
OXFORD UNIV INNOVATION LIMITED [GB]
Oxford University Innovation Limited
The Universtiy of Birmingham
US_20260176700_A1

Resumen de: US20260176700A1

0000 The invention relates to an assay. More specifically, the invention relates to an assay for predicting cardiovascular toxicity of a chemotherapeutic agent.

Application of intestinal bacterium metabolism key gene in preparation of atherosclerosis diagnosis product

NºPublicación:  CN122256497A 23/06/2026
Solicitante: 
UNIV JIANGNAN
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CN_122256497_PA

Resumen de: CN122256497A

The invention discloses application of an intestinal bacterium metabolism key gene in preparation of an atherosclerosis diagnosis product, and belongs to the technical field of biological medicines. The invention establishes a CRISPR/Cas12a detection method based on RPA and crRNA array mediation, can accurately detect eight intestinal bacteria metabolism key genes closely related to cardiovascular diseases, and realizes rapid diagnosis according to the detection result. The invention provides a new technical means for evaluating the risk of cardiovascular diseases, and has potential application value in the aspects of early screening, prediction and judgment of diseases.

DISCOVERY OF THE BLOOD CIRCULATING BIOMARKERS OF THE SIDE EFFECTS INCLUDING ACUTE KIDNEY INJURY COMPARING BEFORE AND AFTER THE OPEN-HEART SURGERIES INCLUDING COX-MAZE PROCEDURE FOR THE CARDIOVASCULAR DISEASES AND USES THEREOF

NºPublicación:  KR20260094238A 22/06/2026
Solicitante: 
SEOUL NAT UNIV HOSPITAL [KR]
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KR_20260094238_PA

Resumen de: WO2026127584A1

The present invention relates to a biomarker for diagnosing or predicting the onset of postoperative acute kidney injury, and a method for diagnosing or predicting the onset of postoperative acute kidney injury using same. Specifically, the present invention relates to a method for diagnosing or predicting the onset of acute kidney injury by using, as a biomarker, miR-451a, miR-185-5p, miR-221-3p, miR-191-5p, miR-484, miR-144-3p, miR1972, miR-4478, miR-1273h-5p, miR-619-5p, miR-4430, or miR-548aq-3p in a blood sample following open-heart surgery.

Biomarker for diagnosing or predicting prognosis of stroke and uses thereof

Nº publicación: KR20260094326A 22/06/2026

Solicitante:

서울대학교병원

KR_20260094326_PA

Resumen de: KR20240114848A

The present invention relates to a marker composition, a kit, a panel, and a method for providing information for diagnosing, generating, or predicting prognosis of stroke. The present invention is a novel tool capable of predicting the diagnosis, occurrence, progress, or prognosis of a stroke. the present invention has excellent sensitivity and can be easily analyzed without using a biopsy, thereby being usefully used for early diagnosis, occurrence, or prognosis prediction of a stroke.

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