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322
resultados
Última actualización
25/08/2026 [07:57:00]
Resultados 275 a 300 de 322
Resumen de: US20260186004A1
0000 It has been established that increased levels of lactylated of tau protein in the brain and CNS is associated with tauopathies and neurodegenerative diseases, and increased levels of lactylated lysine on tau protein has been established as a marked for AD. Compositions and methods for the detection and treatments of tauopathies have been developed. In some forms, the methods identify and quantify lactylated lysine on tau protein in a biological sample from a subject to diagnose a tauopathy, such as AD. In some forms, the methods identify a subject as having or at risk of having a tauopathy. In some forms, the methods include treating the tauopathy. Compositions to identify a tauopathy include lactylated tau binders, such as antibodies are also described. Compositions to treat or prevent a tauopathy, such as lactylated tau peptides having a defined lactyllysine, are also described.
Resumen de: WO2026143158A1
Disclosed herein methods and compositions for diagnosing, stratifying risk, and treating hypoxia-related brain disorders using NHIP genetic variants, DNA methylation signatures, and circulating NHIP peptide levels, as well as NHIP based peptide therapeutics for improving neurological and developmental outcomes.
Resumen de: WO2026142290A1
The present invention relates to a biomarker-specific binding probe and a use thereof. By introducing the probe into a nanopore, it is possible to accurately and rapidly detect the presence and abundance of a specific biomarker in a sample.
Resumen de: WO2026137051A1
The present disclosure generally relates to a modified receptor and/or a modified ligand and uses thereof. The modified receptor and/or modified ligand can be used to establish molecular signalling between two biological components, rendering the modified receptor and/or modified ligand suitable in a broad array of applications.
Resumen de: WO2026142751A1
Aspects of the disclosure include methods of treating an autoimmune disease, including reducing the need for chronic immunosuppression, and for effectuating immune reset and/or producing a naive B cell repertoire in a subject in need thereof, the methods comprising administering a therapeutically effective amount of anti-CD20 yδ T cells to the subject, wherein the anti-CD20 yδ T cells express a chimeric antigen receptor (CAR) comprising a binding domain that specifically binds to CD20.
Resumen de: US20260185138A1
0000 A coupled tethered enzyme luminescence assay for measuring the amount of enzymatic activity of neural specific enolase in a liquid blood sample taken from a patient. The assay has a test well and a positive control well. The test well has a number of components including an inhibitor and a number of first tethered enzyme nanobots formed by tethering pyruvate kinase enzyme to silica nanoparticles, and a number of second enzyme nanobots formed by tethering luciferase molecules to silica nanoparticles for oriented immobilization of the tethered enzymes pyruvate and luciferase. The pyruvate kinase and luciferase enzymes have two differing types of affinity tags. One type of affinity tag facilitates extraction of enzymes from a liquid and another affinity tag for tethering to a silica nanoparticle. The positive control well includes the components of the test well and an added preset amount of enolase enzyme.
Resumen de: US20260183364A1
The present disclosure relates to methods for treating or alleviating a fetal alcohol spectrum disorder (FASD) in a subject, the method comprising administering to the subject an effective amount of an apolipoprotein E (APOE)-modulating therapeutic, thereby treating or alleviating the FASD.
Resumen de: JP2026110170A
【課題】本発明者らは、特に老化組織において炎症を抑制し得る素材をスクリーニングする技術の提供を主な目的とした。【解決手段】上記課題は、工程Ｂ：１５回以上継代された血管内皮細胞に被験物質を接触させる工程、並びに工程Ｃ：ＩＬ－６、ＩＬ－８、ＣＸＣＬ１、ＰＡＩ－１、ＭＭＰ－１、ＩＣＡＭ－１、ＶＣＡＭ－１、Ｅ－ｓｅｌｅｃｔｉｎ、及びＣＣＬ２からなる群より選択される少なくとも１種の炎症関連因子の、工程Ｂで被験物質を接触させた血管内皮細胞における発現量を評価する工程を含む方法により、解決され得る。【選択図】なし
Resumen de: WO2026139512A2
The present invention relates to methods of producing a conformationally constrained peptide in cellulo using a pnictogen-containing crosslinker. The present invention also relates to conformationally constrained peptides obtainable by said methods and a method for screening peptide libraries for transcription factor agonists that tests whether said conformationally constrained peptide inhibits association between two candidate binding partners. The present invention also relates to the use of a pnictogen-containing cross-linker in a method of producing a conformationally constrained peptide in cellulo. The present invention also relates to recombinant peptides comprising three thiol-/selenol-containing residues linked to a pnictogen-containing cross-linker. The present invention also relates to a kit for use in said methods.
Resumen de: WO2026139605A2
The invention relates to biomarkers for mitochondrial disease. Signalling lipids were identified as having good correlations with disease severity. Several of these biomarkers were found to correlate with treatment efficacy. Signalling lipids such as 15-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoic acid showed a positive correlation with disease severity and showed a corresponding decrease after treatment of the disease.
Resumen de: WO2026142185A1
In a surface-enhanced Raman scattering-based method for testing drug reactivity of cerebrovascular cells, a SERS substrate is manufactured. A SERS substrate array including a plurality of the SERS substrates is manufactured. Cells are cultured on the SERS substrate array. A drug is administered to the cultured cells. A Raman signal is measured from the cells to which the drug is administered. An optimal drug is selected from among the administered drugs on the basis of the measured Raman signal.
Resumen de: AU2024388318A1
The present disclosure provides precision medicine or personalized therapy of using a Sigma-1 receptor agonist in treating neurological disease or disorder. The precision medicine or personalized therapy involves patient selection through differentially expressed genes or affected biological pathways related to the Sigma-1 receptor agonist therapy. Also provided are kits for practicing the methods.
Resumen de: US20260184764A1
0000 The present invention relates to proteins suitable for being used as scaffolds to which a peptide of interest is bound, or which are comprised within a conjugate to which an agent of interest is attached. It also relates to said conjugates suitable for the selective delivery of their conjugated agents of interest to specific cell and tissue types, wherein said agent 5 can be a therapeutic agent or an imaging agent. It also relates to nanoparticles comprising such conjugates and the therapeutic uses thereof.
Resumen de: JP2024019568A
To provide enrichment of an antigen-specific antibody for analytical and therapeutic use.SOLUTION: The present invention relates to a method for eliminating the interference described in the specification using particles (e.g., microparticles, nanoparticles; magnetic, non-magnetic) containing surfaces containing the capturing portions described in the specification, or enriching biomarkers, especially antibodies, prior to diagnostic testing, or isolating and using the antibodies for prophylactic or therapeutic purposes. The method described in the specification is a simple, efficient, and cost-effective method for the conditioning of biological samples for managing and mitigating a number of known sample-specific interferences that can lead to erroneous test results and increased risk to patient safety, such as heterophil antibodies in patients treated with monoclonal mouse antibodies or those receiving them for diagnostic purposes.SELECTED DRAWING: None
Resumen de: US20260185056A1
An in vitro method of producing a fused tissue culture with at least three different tissues including selecting a spatial shape for attaching the at least three different tissues to each other, placing the at least three different tissues into contact in the spatial shape, culturing the at least three different tissues under conditions that maintains tissue fusion of the at least three different tissues is disclosed. Further provided is a tissue culture comprising a planar or linear fusion of at least three different neural or neuronal tissues, uses thereof and means for its production.
Resumen de: US20260185993A1
0000 A functional peptide modified magnetic composite nanobead, and a method and an application thereof for detecting β-secretase (BACE1) and screening its inhibitors are provided. The chemical composition of the magnetic composite nanobead is: ferroferric oxide (Fe<3>O<4>) nanoclusters used as magnetic cores, the surface of the magnetic cores coated with a silica shell, the surface of the shell connected with an ethylene diamine tetraacetic acid (EDTA) modification layer, and Co<2+> or Ni<2+> ions chelated on the EDTA layer, and the Cy5 fluorescein labeled functional peptide coated on the surface of magnetic composite nanobead by the interaction between Co<2+> or Ni<2+> ions and hexahistidine-tag.
Resumen de: US20260187803A1
0000 Integrated platforms, systems, and associated processes for measuring lifespan, body size and shape, activity, pathology, pigmentation/color, and multiple in vivo molecular biomarkers using multiple cameras are described. The integrated platform includes a plate and trays supported on the plate. Each tray can hold animals. The integrated platform also includes an imaging module with a first camera and a second camera. The first camera can capture first images associated with movement of the animals and the second camera can capture second images and third images associated with biomarkers of the animals.
Resumen de: US20260184770A1
Disclosed herein are methods of diagnosing, selecting, monitoring, and treating subjects with Alzheimer's disease (AD) or suspected of having AD or another disorder associated with amyloid accumulation in the brain using a tau PET level.
Resumen de: US20260184772A1
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of Alzheimer's disease and related tauopathies. The present invention also provides a method for a prophylactic and therapeutic treatment of Alzheimer's disease and other neurodegenerative tauopathies. This method entails the injection of antibodies and/or peptide vaccines that elicits an immune response directed to pathological tau proteins and tau deposits in the brains of patients. Suitable vaccines represent a tau peptide carrying one or more of the tau therapeutic epitopes provided herein.
Resumen de: WO2026137685A1
The present application relates to the technical field of immunochromatography, and in particular, to a test strip for detecting β-amyloid protein and the use thereof. In the present application, colored microspheres are conjugated to a β-amyloid monoclonal antibody via covalent bonds, and then the conjugate is coated onto a conjugate pad. Compared with colloidal gold, the colored microspheres exhibit greater stability and higher sensitivity. Additionally, the colored microspheres feature bright and diverse colors, uniform particle sizes, good monodispersity, and strong reproducibility of detection results. The test strip provided by the present application has the advantages of simplicity, rapidity and high timeliness, requires no additional reagents, instruments and professional personnel, and supports on-site operation. By means of simply applying a to-be-detected sample to a sample loading port of the test strip, a detection result can be interpreted within 15 min. The result interpretation is visual, intuitive, accurate and straightforward, with a low risk of human errors such as false positives and false negatives.
Resumen de: CN122307112A
0001 本申请涉及一种神经退行性变标志物检测试剂及检测方法。该神经退行性变标志物检测试剂包括产氧剂、催化剂和能够与待测样本中的待测神经退行性变标志物特异性结合的免疫检测试剂；其中，产氧剂在催化剂的作用下发生反应生成氧气，生成的氧气用于增加反应体系中的氧含量；免疫检测试剂能够利用反应液中的活性氧产生光信号，待测靶分子选自神经退行性变标志物。本申请提供的方案，能够在神经退行性变标志物浓度水平较低时，提高光信号值，有利于提高对神经退行性变标志物的检出能力。
Resumen de: CN122302156A
0001 本发明提供一种胆碱仿生双亲聚合物纳米盘，所述胆碱仿生双亲聚合物纳米盘的制备原料包括聚甲基丙烯酸酯共聚物；所述聚甲基丙烯酸酯共聚物由2‑甲基丙烯酰氧乙基磷酰胆碱与甲基丙烯酸己酯经聚合反应制备得到。该胆碱仿生双亲聚合物纳米盘具备高效穿越BBB的能力和脑靶向能力，在体外BBB模型和小鼠体内都能高效的通过胆碱转运受体跨越BBB，该胆碱仿生双亲聚合物纳米盘的盘状形态和纳米级尺寸促进了血管、基质和细胞屏障的有效渗透，具有卓越的实体瘤浸润能力。本发明提供一种上述的胆碱仿生双亲聚合物纳米盘的制备方法以及上述的胆碱仿生双亲聚合物纳米盘在制备脑肿瘤的检测试剂或脑肿瘤的预防、治疗药物中的应用。
Resumen de: AU2020258381A1
Disclosed herein are methods for detecting a biological or chemical entity in a sample, wherein the biological or chemical entity is associated with extracellular vesicles. The methods disclosed comprise the steps of a) processing the sample, (b) using a detection assay to detect the presence of extracellular vesicles and to isolate the extracellular vesicles, (c) processing the extracellular vesicles to expose or release the biological or chemical entity, and (e) detecting the biological or chemical entity released from the extracellular vesicle. In certain embodiments, the extracellular vesicles are associated with proteins, glycoproteins, peptides, lipids, nucleic acids or other cellular components. The detection methods are useful for identifying the presence of microbial antigens related to
Resumen de: CN121263693A
Provided herein are methods for detecting proteins and/or protein variants thereof, the methods comprising adding to a biological sample one or more small molecules and one or more protein binding agents wherein a protein crown is formed on a surface of the protein binding agent, and detecting the protein and/or protein variants thereof in the protein crown by antibody-based technology or proteomic technology. Also provided herein are methods for detecting one or more biomarkers or patterns of one or more biomarkers associated with a disease or health profile condition, as well as methods of diagnosing or predicting a disease in a subject. Compositions comprising one or more small molecules, one or more protein binding agents, and one or more biological samples are also provided.
Nº publicación: JP2026108846A 30/06/2026
Solicitante:
ニューヨークステムセルファウンデーションインコーポレイテッド
Resumen de: WO2018218193A1
The invention relates to methods and compositions for developing basal forebrain cholinergic neurons (BFCNs) from stem cells, and in particular, BFCNs having repaired electrophysiological defects relating to one or more mutations in PSEN2, and to the use of such BFCNs in cell-based therapies to treat Alzheimer's disease.
BOPI
Sede Electrónica
