Alerta

用于管理患者成像的系统、设备和方法

Resumen de: EP4785868A1

A computer-implemented method for managing Cone Beam Computed Tomography, CBCT, imaging of a patient. The method comprises acquiring (102) radiotherapy treatment plan, RTP, information for a RTP. The RTP is for delivering a radiation dose distribution to the patient so as to respect at least one radiotherapy treatment objective. The method further comprises determining (104), based on the acquired RTP information, a measure of sensitivity of the RTP to changes in anatomy of the patient. The measure of sensitivity is a function of position in the patient or a function of radiotherapy beam direction in the RTP. The method further comprises generating (106), based on the determined measure of sensitivity, an imaging protocol for obtaining a reconstructed CBCT image of a volume of the patient by setting a value of at least one parameter in the imaging protocol such that image quality of the reconstructed CBCT image of the patient volume meets an image quality objective for an image processing task. The image quality objective prioritises image quality for positions within the patient volume at which the RTP is sensitive to changes in anatomy. The imaging protocol comprises values for at least one CBCT imaging acquisition parameter and/or at least one CBCT imaging reconstruction parameter.

服薬支援システム、服薬支援方法、及び服薬支援プログラム

Resumen de: JP2026123988A

【課題】服薬情報を照合する際における薬局の薬剤師等や介護施設等の看護師や介護士等の業務時間や業務負荷を削減し、誤薬を防止することができる服薬支援システムを提供する。【解決手段】本発明は、プロセッサと記憶装置を含み、前記プロセッサが服薬情報を照合する服薬支援システムであって、前記プロセッサは、服薬指示書の第１の服薬情報を読み取り可能な第１の服薬情報読取部と、前記服薬指示書上の区画に配置された薬剤収納パック毎の第２の服薬情報を複数同時に読み取り可能な第２の服薬情報読取部と、前記第１の服薬情報と前記第２の服薬情報とを照合する照合部と、を備える。【選択図】 図１

基于磁流变弹性体的膝关节康复辅具、制备及工作方法

Resumen de: CN122478694A

本发明公开一种基于磁流变弹性体的膝关节康复辅具及其制备与工作方法。该辅具包括MRE层、腿部支撑框架、电磁场发生装置及传感模块。MRE层为弧形片状，由热塑性弹性体TPU粉末与羰基铁粉混合粉末经SLS打印成型，弹性模量可随磁场变化。腿部支撑框架含大腿、小腿固定套，两者与MRE层之间设有连接结构。电磁场发生装置由可控电磁线圈、控制器及电源组成。传感模块包含角度传感器与压力传感器，可实时采集膝关节弯曲角度及接触压力数据并传输至控制器。控制器根据反馈数据调节线圈电流，改变磁场强度，进而调控磁流变弹性体层刚度，实现膝关节弯曲角度精准动态控制。本发明个性化适配性好、响应快、结构紧凑、能耗低。

一种生物基可降解单组分弹性树脂及其制备方法和应用

Resumen de: CN122483267A

本发明公开了一种生物基可降解单组分弹性树脂及其制备方法和应用，单组分弹性树脂包括PLA‑PCL嵌段共聚物改性聚氨酯丙烯酸酯、生物基活性稀释剂、潜伏性光热双重固化体系和医用功能助剂；PLA‑PCL嵌段共聚物改性聚氨酯丙烯酸酯以聚乳酸和聚己内酯为软段，以生物基二异氰酸酯为硬段，分子链末端接枝丙烯酸酯双键；生物基活性稀释剂为丙交酯‑己内酯共聚物丙烯酸酯与生物基丙烯酸异辛酯的复配物；潜伏性光热双重固化体系包括封闭型生物基异氰酸酯和光引发剂。本发明树脂完全由生物基原料组成，各组分协同实现高弹性、可降解、单组分稳定存储、光热双重固化的综合性能，保障长期植入的生物安全性与降解可控性。

一种免疫稳态调控纳米制剂在脓毒症治疗中的应用

Resumen de: CN122478960A

本发明公开了一种免疫稳态调控纳米制剂在脓毒症治疗中的应用，属于生物医药技术领域。本发明以天然氨基酸与单糖构建的生物质化合物库为前体，以水为溶剂，采用“自下而上”一步水热法，成功制备出一种色氨酸‑山梨醇碳量子点（WS‑CQDs）。该纳米制剂制备简便、成本低、生物相容性高，且几乎无毒。实验发现，该WS‑CQDs能有效缓解CLP脓毒症小鼠的“一次打击”（过度炎症）并降低“二次打击”（免疫抑制）阶段的死亡率，展现出双重保护作用。这一发现提示该WS‑CQDs是一种能够调控免疫稳态的纳米材料，具有显著的脓毒症治疗潜力与临床转化价值。

一种免疫代谢调控解封型凝胶支架及其制备方法和应用

Resumen de: CN122479202A

本发明公开了一种免疫代谢调控解封型凝胶支架及其制备方法和应用，该支架具有芯鞘结构；芯鞘结构的芯层包含甲基丙烯酰化透明质酸、硅酸镁锂、基质细胞衍生因子‑1α和光引发剂；芯鞘结构的鞘层包含葛根素和锌离子。本发明提供的免疫代谢调控解封型凝胶支架，通过程序化递送PUE/Zn2+与SDF‑1α/Mg2+，实现了巨噬细胞精氨酸代谢重编程与干细胞募集及成骨激活的耦连。该支架能够有效解封骨质疏松微环境中受阻的巨噬细胞Arg‑1/ODC通路，并通过腐胺介导的跨细胞代谢传递，激活BMSCs的成骨程序，为骨质疏松性骨缺损修复提供了新策略。

用于颅颌面整形手术的可吸收复合固定板及其制备方法

Resumen de: CN122479226A

本发明涉及医疗整形技术领域，尤其涉及用于颅颌面整形手术的可吸收复合固定板及其制备方法，包括：采用同轴静电纺丝结合超声辅助接收，制备表面具有串晶结构的增强纤维。对具有串晶结构的增强纤维进行表面引发开环聚合，接枝与基体分子量匹配的聚合物链段，构筑分子级互锁界面。基于骨折区域有限元模型，进行双材料拓扑优化，设计时变刚度骨架。将接枝后的纤维经三维编织制成预成型体，再与拓扑优化骨架通过3D打印实现一体化成型。在成型骨板的骨接触面。本发明中，实现了增强纤维与基体之间的化学键合与物理嵌合双重界面增强，解决了现有可吸收固定板中纤维‑基体界面结合薄弱、在降解过程中易发生界面脱粘导致力学强度过早丧失的问题。

3D打印自适应孔结构调节的口腔生物膜及其制备方法

Resumen de: CN122479208A

本申请涉及一种3D打印自适应孔结构调节的口腔生物膜及其制备方法，3D打印自适应孔结构调节的口腔生物膜包括：按照质量份数包括以下成分：15‑20份的胶原蛋白、60‑80份的聚乳酸‑羟基乙酸共聚物、5‑15份的致孔剂、0.025‑0.1份的光引发剂。本方案能够分别通过胶原蛋白、聚乳酸‑羟基乙酸共聚物和致孔剂的不同降解速率，构建降解体系，有效阻止生长较快的牙龈等软组织细胞侵入骨缺损区，在中期阶段致孔剂降解完成，在膜内部形成微米级的初始孔隙，在后期阶段聚乳酸‑羟基乙酸共聚物逐步水解，使初始孔隙进一步扩大，最终使整个膜体转变为一个具有高孔隙率的三维多孔支架，使得整个生物膜能够匹配骨组织再生各阶段和生长速率，提升了骨引导再生的效率和质量。

一种基于3D打印的牙科种植定位器

Resumen de: CN224572844U

本申请提供了一种基于3D打印的牙科种植定位器，涉及种植定位器领域，包括种植牙定位器本体与支架，所述种植牙定位器本体靠近支架的一侧表面开设有插槽，所述支架与种植牙定位器本体均设置有两个，两个所述支架之间设置有中轴，两个所述支架均转动套设在中轴的外表面，所述支架靠近种植牙定位器本体的一侧表面固定连接有插接柱，所述插接柱的上下两侧表面均开设有收纳槽，所述收纳槽的内部转动连接有转动板，所述转动板的端部与收纳槽的内壁之间固定连接有扭力弹簧。本申请能够在对种植牙定位器本体进行安装与拆卸时较为便捷，减少安装与拆卸过程中的操作步骤，进而实现快速更换不同种植牙定位器本体的功能。

一种模块化生物打印多细胞支架及其制备方法和应用

Resumen de: CN122479217A

本发明涉及一种模块化生物打印多细胞支架及其制备方法和应用。所述模块化生物打印多细胞支架为使用搭载细胞的动态双网络可拼接生物墨水采用生物3D打印技术制备的载细胞模块单元通过拼接组装得到模块化生物打印多细胞支架。所述模块化生物打印多细胞支架可通过调整各载细胞模块单元的生物墨水组分、细胞种类和密度等来灵活调整多细胞支架的生物物理、生物化学和生物学等时空关键特征。本发明所述的模块化生物打印多细胞支架为促进复杂组织再生及器官再造提供一种新策略。

吞咽障碍监测与干预设备、控制方法、设备、介质及产品

Resumen de: CN122478474A

0001 本申请提供一种吞咽障碍监测与干预设备、控制方法、设备、介质及产品，属于健康监测和辅助康复领域，设备包括多模态传感组件、刺激组件和处理单元；处理单元被配置为实时接收多模态生理信号；基于多模态生理信号获得表征当前吞咽功能状态的评估结果；基于评估结果生成干预刺激参数组合；根据干预刺激参数组合控制刺激组件输出干预刺激。本申请在喉部和下颌区域布设了多模态传感组件和刺激组件，并利用处理单元对多模态生理信号进行评估，生成干预刺激参数并执行干预刺激，形成实时闭环处理流程，通过多模态生理信号全面反映吞咽过程中不同生理活动之间的协同关系，还将吞咽功能监测与康复干预进行实时联动，提高干预的精准性和自适应性。

基于FPGA-MCU异构架构的多参数无创健康监测方法和装置、系统、存储介质

Resumen de: CN122478489A

0001 本发明公开了一种基于FPGA‑MCU异构架构的多参数无创健康监测方法，包括以下步骤：S1、多频信号激励与数据采集；步骤S2、FPGA并行实时阻抗解算与数据传输和融合建模；步骤S3、多生理参数融合预测；步骤S4、风险预警和健康评估。本发明将激励频率扩展至2MHz，利用高频条件下皮肤角质层电容效应趋于零的物理特性，结合高频段最小二乘线性拟合建立深层人体组织阻抗等效模型，实现了对皮肤表层干扰的系统性消除；所提取的深层组织等效纯电阻参数与血容量、组织液含量等深层生理指标高度相关，显著突破了现有生物电阻抗技术仅能获取表层阻抗的根本局限，同时借助深层人体阻抗谱能够更有效地检测血糖、血压等生理参数。

基于多模态数据的吞咽功能动态评估方法及传感装置

Resumen de: CN122478452A

本公开是关于一种基于多模态数据的吞咽功能动态评估方法及传感装置。其中，方法包括：同步采集超声影像、颈部声音信号及呼吸信号，从超声影像中客观识别舌骨或甲状软骨的运动轨迹并确定吞咽启动节点，从颈部声音信号中识别声学事件节点和湿音特征，进而确定声学事件节点与吞咽启动节点之间的时间差值，并将吞咽启动节点与呼吸曲线对齐以确定吞咽发生的呼吸相位，最后根据所述时间差值、所述呼吸相位以及湿音特征生成吞咽功能评估结果。本方案实现了吞咽功能的动态精准评估。

一种基于3D打印技术的上肢支具个性化设计方法

Resumen de: CN122481236A

本发明公开了一种基于3D打印技术的上肢支具个性化设计方法，涉及医疗器械3D打印技术领域，包括通过三维扫描采集患者手部、腕部及前臂区域皮肤表面轮廓，形成高密度初始点云数据，经去噪平滑处理重建上肢体表曲面模型并作为支具内腔基准面。预留安全间隙生成支具本体基础数字模型，施加预定均匀力学载荷进行结构分析，识别应力低于设定阈值的冗余材料区域，经拓扑优化在非关键支撑结构处形成规则蜂窝状或网格状镂空结构，得到轻量化模型。再规划医用热塑性聚合物打印路径，采用熔融沉积成型一体化制备支具，可精准去除冗余材料。该方法可实现支具贴合度、力学稳定性与轻量化透气性能的协同优化。

预测增材制造对象的制造结果

Resumen de: WO2025147627A1

Methods and systems for predicting manufacturing outcomes are provided. In some embodiments, a method includes receiving at least one image representing a target geometry of an object to be fabricated using an additive manufacturing process. The method can include generating at least one modified image by inputting the at least one image into a machine learning algorithm. The machine learning algorithm can be trained to determine one or more modifications to the at least one image, where the one or modifications are configured to compensate for predicted deviations from the target geometry of the object when the object is fabricated via the additive manufacturing process based on the at least one image. The method can further include generating instructions for fabricating the object using the additive manufacturing process, based on the at least one modified image.

TRAINING METHOD AND SYSTEM FOR DEPRESSION DETECTION MODEL, AND DETECTION METHOD OF DEPRESSION DETECTION MODEL

Resumen de: WO2026157307A1

A training method and training system for a depression detection model, and a detection method of a depression detection model. The training method comprises: acquiring electroencephalogram training data; performing spectral feature extraction on the electroencephalogram training data to obtain a spectral feature set; performing temporal feature extraction on the electroencephalogram training data to obtain a temporal feature set; performing spectral proxy graph learning on the spectral feature set to obtain a spectral coded representation, and performing temporal proxy graph learning on the temporal feature set to obtain a temporal coded representation; on the basis of the spectral coded representation, performing dual-domain feature fusion on the temporal coded representation to obtain dual-domain fused features; and, on the basis of the dual-domain fused features, updating parameters of an initialized depression detection model to obtain a trained depression detection model. The training method can provide a depression detection model, which helps to improve the objectiveness, detection efficiency and detection accuracy of depression detection.

CLINICAL BRAIN NETWORK IDENTIFICATION DEVICE

Resumen de: AU2026205545A1

CLINICAL BRAIN NETWORK IDENTIFICATION DEVICE Abstract Disclosed herein is a clinical brain network identification device that includes: a pre- processing module for conditioning sensed data from at least one patient; a storage medium for storing conditioned sensed data and corresponding patient metadata; a stochastic data selection module for selecting data from said storage medium that is conditioned sensed data and patient metadata relating to a set of patients; a brain network dynamics generator for receiving clinical scores and stimulus data and generating brain network dynamics being probabilities of a brain state being active at a point in time; a brain network pattern generator for generating brain network patterns, based on said selected data; a brain state inference module for determining inferred brain states based on sensed data and brain network patterns and brain network dynamics; and a therapeutic group prediction module for producing a set of therapeutic group assignments based on inferred brain states. CLINICAL BRAIN NETWORK IDENTIFICATION DEVICE ul u l

CARTILAGE ORGANOID CONSTRUCTED ON BASIS OF DNA-FIBROIN HYBRID HYDROGEL SUSTAINED-RELEASE SYSTEM, METHOD FOR PREPARING SAME, AND USE THEREOF

Resumen de: WO2026157189A1

The present invention relates to a cartilage organoid constructed on the basis of a DNA-fibroin hybrid hydrogel sustained-release system, a method for preparing same, and use thereof. The DNA-fibroin hybrid hydrogel sustained-release system is a hydrogel system obtained after a pre-mixed solution of the DNA-fibroin hybrid hydrogel sustained-release system is printed by means of a digital light processing system, wherein the pre-mixed solution of the DNA-fibroin hybrid hydrogel sustained-release system comprises DNA, fibroin, an acrylated RGD peptide, an acrylated polyethylene glycol NHS ester, glucosamine, TD-198946, and lithium 2,4,6-trimethylbenzoylphosphate. Compared to the prior art, the glucosamine and TD-198946 introduced into the DNA-fibroin hybrid hydrogel sustained-release system of the present invention can significantly improve the efficiency of promoting the chondrogenic differentiation of bone marrow mesenchymal stem cells. The present invention can be transplanted as a cartilage graft to a cartilage defect site to promote cartilage regeneration and repair.

Systems and Methods for Planning, Controlling and/or Delivering Radiotherapy and Radiosurgery using Combined Optimization Of Dynamic Axes (CODA)

Resumen de: US20260216532A1

Methods and systems for radiation treatment planning and delivery apply a CODA cube. Cost values in the CODA cube may be used in the optimization of couch, collimator, and gantry angles simultaneously. Trajectories generated using the CODA cube show significant benefits when compared to conventional VMAT. A statistically significant sparing to OAR maximum radiation doses was seen. CODA plans resulted in a reduction to maximum radiation dose in OARs of 20.6% (p<0.01), with maximum brainstem radiation dose decreased by 2.63 Gy (p=0.031) on average. Mean reduction in total MU was 8.6% (p=0.156), and a mean decrease in non-target brain tissue receiving 12 Gy or higher was 3.9% (p=0.16), when compared to standard VMAT methods (n=7).

METHODS, SYSTEMS, AND DEVICES FOR ANALYZING LUNG IMAGING DATA

Resumen de: US20260215749A1

0000 Devices, methods, and systems are provided for analyzing lung imaging data. A server computing device receives imaging data of a lung over a network from a client computing device and analyzes the imaging data to identify lung, airways, and blood vessels, segment the lung into lobes, subtract airways, calculate volumes, calculate emphysema scores, identify fissure locations, calculate fissure completeness scores. A reconstruction of the fissures indicating locations where the fissures are incomplete and a report comprising fissure scores, volumes, and emphysema scores are created.

METHODS AND SYSTEMS FOR THE PRODUCTION AND USE OF ORTHODONTIC BRACKET PLACEMENT GUIDES

Resumen de: US20260215885A1

Disclosed herein are methods of producing a bracket guide, such as an orthodontic bracket guide. The methods may include placing a bracket model on a tooth object of a dentition model, generating a bracket guide foundation volume such that the generating exposes at least a portion of the bracket model, and producing a physical bracket guide based, at least in part, on the bracket guide foundation volume. Also disclosed herein are a computer-readable storage medium comprising program instructions that perform the methods, and a computing system comprising one or more processors and the computer-readable storage medium.

METHODS AND SYSTEMS FOR ACTIVITY DETECTION AND QUANTIFICATION OF MOVEMENT KINEMATICS

Resumen de: US20260221277A1

0000 The techniques described herein relate to computerized methods and systems for determining a type and/or kinematic characteristics of activities performed by a subject using one or more statistical models and training of such models. In some embodiments, a system may receive sensor data from one or more sensors indicating movement of one or more body portions of a subject, and using an activity identification statistical model to determine a type of activity. In some embodiments, a system may receive sensor data from the one or more sensors, and use a kinematic characteristic statistical model to determine one or more kinematic characteristics of the activity based on the sensor data. In some embodiments, the output of the activity identification statistical model and/or the output from the kinematic characteristic statistical model may be used with the other model. In some embodiments, the above concepts may be implemented using a single statistical model.

TABLET ULTRASOUND SYSTEM

Resumen de: US20260215758A1

0000 Exemplary embodiments provide systems and methods for portable medical ultrasound imaging. Preferred embodiments utilize a tablet touchscreen display operative to control imaging and display operations without the need for using traditional keyboards or controls. Certain embodiments provide ultrasound imaging system in which the scan head includes a beamformer circuit that performs far field sub-array beamforming or includes a sparse array selecting circuit that actuates selected elements. Exemplary embodiments also provide an ultrasound engine circuit board including one or more multi-chip modules, and a portable medical ultrasound imaging system including an ultrasound engine circuit board with one or more multi-chip modules. Exemplary embodiments also provide methods for using a hierarchical two-stage or three-stage beamforming system, three dimensional ultrasound images which can be generated in real-time.

POLYOL SWEETNERS AND CARDIOVASCULAR AND THROMBOTIC EVENT RISK

Resumen de: US20260219274A1

0000 Provided herein are compositions, systems, kits, and methods for determining the level of a polyol sweetener in a biological sample from a subject (e.g., a subject with, or suspected of having, or at increased risk of developing: a cardiovascular disease, a major adverse cardiovascular event, or enhanced thrombosis). In certain embodiments, determining such polyol sweetener levels are higher than a control level allows a subject to be prescribed, or administered, a CVD therapeutic, anti-thrombotic agent, or lifestyle change to reduce consumption of such polyol sweeteners. In certain embodiments, xylitol is detected in a biological sample from a subject such that xylitol's structural isomers arabitol and rabitol are distinguished. In other embodiments, erythritol is detected in a biological sample from a subject such that erythritol's structural isomer threitol is distinguished.

SYSTEM, METHOD, AND COMPUTER PROGRAM PRODUCT FOR CUSTOMIZED MEDICAL KIT ASSEMBLY AND INVENTORY MANAGEMENT

Nº publicación: US20260215873A1 30/07/2026

Solicitante:

BECTON DICKINSON AND CO [US]
Becton, Dickinson and Company

Resumen de: US20260215873A1

Systems, methods, and computer program products for customized medical kit assembly and inventory management are disclosed. A method may include receiving, from a user device, an input associated with a selection of a set of medical devices for a medical kit. The set of medical devices may be dispensed from a storage location in response to receiving the input. The set of medical devices dispensed from the storage location may be packaged at a packaging location to form the medical kit. The medical kit may be dispensed from a fulfillment location.