Alerta

Disposable safe insulin pen needle

Resumen de: CN224387851U

The utility model discloses a disposable safe insulin pen needle head in the field of needle heads, which comprises a protective cover and anti-skidding lines arranged on the outer side of the protective cover, a butt joint internal thread is arranged on the inner cambered surface of the protective cover, a puncture needle is connected to the bottom of the inner wall of the protective cover, an installation internal thread is arranged on the inner cambered surface of the shell, and an installation piece is arranged at the center of the shell. According to the disposable insulin pen needle self-destruction device, the use economical efficiency of the disposable insulin pen needle can be effectively improved, and meanwhile it is guaranteed that the disposable insulin pen needle self-destruction device can achieve the disposable self-destruction effect with fewer parts; and a guide groove or a bulge structure is not used, so that the part production difficulty of the device is reduced.

Insulin pen

Resumen de: CN224387860U

The utility model discloses an insulin pen which comprises a pen body, a pen refill frame, a pen refill, a needle head and a pen cap and further comprises a magnetic block, a Hall sensor, a shell, a single chip microcomputer module, a setting button, an alarm module and a power module. The magnetic block is arranged in the piston, and the Hall sensor is arranged at the bottom of the scale window of the refill frame and used for detecting the change of the magnetic field intensity and generating a voltage signal; the shell is arranged on the side wall of the refill frame, the single-chip microcomputer module and the power module are arranged in the shell, and the setting button and the alarm module are arranged on the surface of the shell. The single-chip microcomputer module is electrically connected with the Hall sensor, the setting button and the alarm module, the setting button is used for setting a voltage threshold value, and the single-chip microcomputer module is used for converting a voltage signal generated by the Hall sensor into a voltage value and controlling the alarm module to give an alarm when the voltage value is larger than the set threshold value. According to the utility model, when the remaining insulin in the refill is insufficient, an alarm is given out so as to remind a user of replacing a new refill.

Storage device for insulin injection

Resumen de: CN224387843U

The utility model discloses an insulin injection storage device which comprises a box body, a hinge is arranged on one side of the box body, a box cover is arranged on one side of the hinge, a fixing block and a supporting block are fixedly connected to the inner wall of the box body, a first fixing shaft is fixedly connected to the top of the fixing block, and a second fixing shaft is fixedly connected to the top of the supporting block. According to the device, a penholder part can be conveniently and rapidly clamped and positioned, so that the storage stability of an insulin injection pen is improved, the situation that an injector is damaged due to shaking is prevented, the use convenience is effectively improved, and the practicability is high. Meanwhile, the pen cap part can be conveniently clamped and positioned, the convenience in storage is further improved, and the pen cap part can be conveniently rotated, so that the pen cap does not need to be positioned when the injection pen is taken, and the condition that the pen cap is damaged or lost due to falling is prevented.

Consistency alignment and fusion method for terminal blood glucose detection data and related equipment

Resumen de: CN122263026A

The invention provides a consistency alignment and fusion method for terminal blood glucose detection data and related equipment. The method comprises the following steps: acquiring original acquisition data and corresponding environmental parameters of at least one blood glucose detection terminal, individual physiological difference parameters of a target user and historical blood glucose change feedback data; inputting the individual physiological difference parameters into the physiological model to generate a theoretical blood glucose change curve; performing matching on the basis of original acquisition data and a theoretical blood glucose change curve, and constructing a blood glucose time offset correction model; inputting the original collection data and the corresponding environmental parameters into a blood glucose time offset correction model, and obtaining the time delay amount of the original collection data; mapping the original acquisition data to a standard time axis based on the time delay amount to generate aligned blood glucose data; and performing multi-dimensional feature extraction on the aligned blood glucose data, calculating a corresponding confidence weight, and obtaining a fusion blood glucose optimal estimation value and a confidence interval at the current moment. And a reliable blood glucose detection result can be stably output.

Application of CADM1 in preparation of medicine for treating gestational diabetes

Resumen de: CN122256496A

The invention relates to the technical field of biology, in particular to application of CADM1 in preparation of a medicine for treating gestational diabetes. According to the application, the detection reagent for detecting the expression level of the CADM1 is used for preparing the medicine for detecting the gestational diabetes mellitus. The application is based on the earlier stage research of the applicant that the expression level of CADM1 in the placental trophoblast of a gestational diabetes patient is reduced, the in-vitro experiment finds that CADM1 can promote the placental trophoblast cells to carry out proliferation, migration, invasion and other activities, and by constructing the mRNA expression quantity of CADM1 and the subject working characteristic curve of the GDM patient, the application of CADM1 in the placental trophoblast of the gestational diabetes patient can be determined. The mRNA expression quantity of the CADM1 is related to the GDM patient, which indicates that the CADM1 is related to the placental trophoblast of the gestational diabetes mellitus patient, which indicates that the detection of the gestational diabetes mellitus can be realized through the detection reagent for detecting the expression level of the CADM1.

Controlled release device, preparation method thereof and intelligent microneedle closed-loop system

Resumen de: CN122250999A

The invention relates to the technical field of medical instruments, in particular to a controlled release device, a preparation method thereof and an intelligent microneedle closed-loop system. The controlled release device comprises a metal microneedle, a doped polypyrrole film covering the surface of the metal microneedle and a medicine loaded on the doped polypyrrole film. According to the controlled release device, the electric regulation and control on-demand release of the hypoglycemic drugs is realized, the melbine can accumulatively release 41.1 micrograms within 400 minutes, and a new possibility is provided for personalized treatment of diabetes mellitus. Meanwhile, an intelligent micro-needle closed-loop system is constructed by utilizing a micro-needle sensor, real-time blood glucose monitoring and on-demand administration linkage control are realized, and no tissue inflammation is caused after the system is continuously worn for seven days.

Curcuma longa-mesenchymal stem cell fusion exosome and application thereof in treating diabetic wounds

Resumen de: CN122256329A

The invention belongs to the technical field of biological medicines, and particularly relates to a turmeric-mesenchymal stem cell fusion exosome and application thereof in treating diabetic wounds. A mixed exosome suspension is subjected to short-time and low-power ultrasonic fusion technology through an ultrasonic instrument, the turmeric exosome and the mesenchymal stem cell exosome are fused, the fused exosome is prepared, the fused exosome is further prepared into the fused exosome gel, and the gel is prepared into the turmeric exosome gel. The problem that the delivery efficiency is low when the exosome and the mesenchymal stem cell exosome are independently used is solved, and the diabetic wound healing effect is remarkably improved.

Diabetes rapid detection device

Resumen de: CN122251001A

The invention discloses a rapid diabetes detection device, relates to the technical field of diabetes detection, and is used for solving the problems that a puncture needle structure of an existing device is inconvenient to replace and a detection result is inaccurate due to insufficient puncture depth, the rapid diabetes detection device comprises a shell and a base, a detection element is arranged in the shell, and a display screen and a control button are arranged above the shell; a multifunctional blood sampling mechanism and a test paper clamping mechanism are arranged in the shell; the puncture needle assembly convenient to replace is arranged in the shell, the puncture needle assembly rebounds through adsorption and release of the electromagnetic part, puncture and blood collection are carried out, the maximum puncture depth of the puncture needle is adjusted in cooperation with the adjusting effect of the puncture needle limiting bolt, adjustment is carried out in cooperation with the actual situation, it is ensured that the detection result is accurate, and the detection efficiency is improved. And a disinfectant is conveyed to the aseptic cotton on the side part before puncture for disinfection, so that the safety of puncture operation is ensured.

Systems and methods for analyzing blood glucose and changing human behavior

Resumen de: US12665067B1

Methods and systems are described for a computer-implemented method for managing behavior in a subject, the method comprising: monitoring a plurality of behavioral events, each event being correlated to a timestamp within a time period; identifying a pattern in the plurality of behavioral events; generating, based on the identified pattern, personalized content for the subject; generating one or more nudges for the subject based on the personalized content, wherein the one or more nudges comprise prompts or suggestions aimed at encouraging adherence to executing suggested behavior changes provided in the personalized content; and causing presentation of the personalized content and the one or more nudges to the subject.

High-activity duck embryo liver primary cell as well as preparation method and application thereof

Resumen de: CN122256233A

The invention discloses a high-activity duck embryo liver primary cell as well as a low-cost preparation method and application thereof. The preparation method comprises the following steps: obtaining and pre-treating duck embryo liver tissues, digesting and separating a compound enzyme, preparing a cell suspension, culturing the primary cell and maintaining the activity of the cell. The method is characterized in that a composite digestive juice composed of collagenase I, trypsin and DNase I in a specific weight ratio is used for mild digestion, and a complete culture medium which is definite in component and does not contain non-commercial growth factors is adopted for culture; the complete medium comprises synergistic components such as DMEM/F12, fetal calf serum, an epidermal growth factor, a hepatocyte growth factor, an insulin-transferrin-selenium mixture and the like. The duck embryo liver primary cell prepared by the invention has the advantages of high yield, high survival rate and excellent liver specificity function, and can well maintain activity and function after passage and cryopreservation.

Dabigatran bleeding risk prediction method based on machine learning

Resumen de: CN122266758A

The invention discloses a dabigatran bleeding risk prediction method based on machine learning, and relates to the technical field of computer-aided drug risk management.The method comprises the steps that missing values are processed through a multiple interpolation method by obtaining a base line and follow-up visit data of a patient; on the basis of HAS-BLED scores, candidate variables are screened from the potential risk factors through a LassoCV algorithm, anemia, insulin use and antifungal agent use are determined through clinical correlation analysis to serve as newly-added predictive variables, and a predictive variable set is constructed; and finally, training the model by adopting a random forest or a limit gradient lifting algorithm so as to output a bleeding risk assessment result of the to-be-tested individual. According to the method, the machine learning algorithm is combined, the prediction precision of the bleeding risk of the Dabigatran in the Chinese non-valvular atrial fibrillation patient is improved, the problem that the traditional HAS-BLED scoring prediction accuracy is insufficient is solved, and a more reliable basis is provided for clinical individualized anticoagulant treatment decision.

BLOOD GLUCOSE CONTROL SYSTEM

Resumen de: WO2021011738A1

A glucose level control system can autonomously modify therapy provided to a subject based on a comparison of the effect of different values for a control parameter. The system can deliver therapy to the subject during a first therapy period using a first value for the control parameter and determine a corresponding first effect to the first therapy by analyzing glycemic control of blood glucose in the subject. The system may autonomously generate a second value for the control parameter, and determine a second effect corresponding to a second therapy provided during a second time period using the second value. By comparing the effects of the two therapy periods, a value for the control parameter that provides improved blood glucose level management can be determined.

NOVEL SNAP PEA VARIETY SUGAR 204

Nº publicación: CA3285613A1 21/06/2026

Solicitante:

SYNGENTA CROP PROT AG [CH]
SYNGENTA CROP PROTECTION AG

Resumen de: US20260144222A1

0000 The present invention provides novel snap pea cultivar Sugar 204 and plant parts, seed, and tissue culture therefrom. The invention also provides methods for producing a pea plant by crossing the pea plants of the invention with themselves or another pea plant. The invention also provides pea plants produced from such a crossing as well as plant parts, seed, and tissue culture therefrom.