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Resultados 238 resultados
LastUpdate Última actualización 22/04/2026 [07:25:00]
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Solicitudes publicadas en los últimos 60 días / Applications published in the last 60 days
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用于检测化合物对蛋白质、RNA或DNA相互作用的影响的方法和工具

NºPublicación:  CN121569192A 24/02/2026
Solicitante: 
伊科托斯法国国家健康与医学研究院埃弗里瓦尔德桑讷大学
CN_121569192_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

抗人TNFα蛋白单克隆抗体的制备及其应用

NºPublicación:  CN121554584A 24/02/2026
Solicitante: 
利德健康科技(广州)有限公司
CN_121554584_A

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

判定方法、判定装置及びコンピュータプログラム

NºPublicación:  JP2026031463A 24/02/2026
Solicitante: 
住友化学株式会社
JP_2026031463_PA

Resumen de: US2018099049A1

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.

判定方法、判定装置及びコンピュータプログラム

NºPublicación:  JP2026031464A 24/02/2026
Solicitante: 
住友化学株式会社
JP_2026031464_PA

Resumen de: US2018099049A1

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.

一种基于信号放大的P-Tau231单分子免疫检测试剂盒及其应用

NºPublicación:  CN121559087A 24/02/2026
Solicitante: 
合肥国研汉因检测科技有限公司
CN_121559087_PA

Resumen de: US2018099049A1

Stable lyophilized therapeutic protein compositions and their methods of manufacture are provided. Specifically, the use of water as a solid cake plasticizer and protein stabilizer is described. Also, the inclusion of a multicomponent stabilizer comprising a larger molecular entity and a smaller molecular entity is described. Also, the inclusion of post-drying annealing under certain conditions improves protein stability. Proteins are predicted to remain stable over 24 months at 25° C.

WWP1在制备预防和/或治疗主动脉夹层药物中的应用

NºPublicación:  CN121550448A 24/02/2026
Solicitante: 
南京鼓楼医院
CN_121550448_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种基于结构动力学导向的proBDNF与mature BDNF比值检测的试剂盒及其制备方法

NºPublicación:  CN121559089A 24/02/2026
Solicitante: 
北京华瑞康源生物科技发展有限公司
CN_121559089_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

用于诊断心力衰竭血瘀证的标志物组合及其应用

NºPublicación:  CN121555605A 24/02/2026
Solicitante: 
中医药广东省实验室广东省中医院(广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院)
CN_121555605_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

一种蛋白连接酶介导的特异性修饰多肽的合成方法

NºPublicación:  CN121554563A 24/02/2026
Solicitante: 
华东理工大学华东师范大学
CN_121554563_PA

Resumen de: CN121554563A

本发明公开了一种蛋白连接酶介导的特异性修饰多肽的合成方法,属于生物工程技术领域。本发明解决了现有技术中磷酸化Tau蛋白难以大规模生产的问题,通过使用Tau多肽来替代全长位点特异性磷酸化Tau蛋白用作临床诊断试剂盒中阳性标品,利用蛋白连接酶催化,实现分段合成含有磷酸化特异性修饰多肽,可将不同来源的多肽在温和条件下高效、定向地连接起来,从而获得结构完整、功能多样的目标蛋白或多肽分子,有效提高肽键合成生产效率。

一种双重检测NFL和NFH蛋白的单分子免疫法试剂盒

NºPublicación:  CN121559086A 24/02/2026
Solicitante: 
合肥国研汉因检测科技有限公司
CN_121559086_PA

Resumen de: CN121559086A

本发明属于分子检测技术领域,提供一种双重检测NFL和NFH蛋白的单分子免疫法试剂盒。本发明提供的试剂盒包括固定特异性捕获抗体的固相载体、识别不同表位且标记可区分信号标记物的检测抗体,及洗涤液、封闭液、校准品、质控品,通过夹心免疫反应结合单分子检测技术,能够同步检测样品中NFL和NFH的含量。本发明提供的试剂盒,检测灵敏度可达fg/mL级别,且特异性强、操作简便,无需创伤性脑脊液采集,适用于神经退行性疾病的早期诊断、病情监测及疗效评估。

基于荧光探针的ATP水解酶抗体高效筛选法

NºPublicación:  CN121559077A 24/02/2026
Solicitante: 
岳耀峰
CN_121559077_PA

Resumen de: CN121559077A

本发明公开了基于荧光探针的ATP水解酶抗体高效筛选法,包括生化体系和细胞体系两种检测方案,在生化体系中,通过定量ENTPD2蛋白水解ATP后剩余量,直接计算抗体抑制率;在细胞体系中,利用过表达ENTPD2的细胞验证抗体对跨膜酶的抑制功能。该生化体系方法无需抗体纯化,仅需5-15μL B细胞上清液即可完成初筛,筛选准确度高(细胞体系可用作验证筛选得到的抗体),与体内药效结果一致,适用于抗ENTPD2抗体药物的开发,显著降低研发成本。

基于时空可控免疫反应的多模态神经疾病诊断芯片及方法

NºPublicación:  CN121559084A 24/02/2026
Solicitante: 
浙江格物致知生物科技有限公司
CN_121559084_PA

Resumen de: EP1000000A1

The invention relates to an apparatus (1) for manufacturing green bricks from clay for the brick manufacturing industry, comprising a circulating conveyor (3) carrying mould containers combined to mould container parts (4), a reservoir (5) for clay arranged above the mould containers, means for carrying clay out of the reservoir (5) into the mould containers, means (9) for pressing and trimming clay in the mould containers, means (11) for supplying and placing take-off plates for the green bricks (13) and means for discharging green bricks released from the mould containers, characterized in that the apparatus further comprises means (22) for moving the mould container parts (4) filled with green bricks such that a protruding edge is formed on at least one side of the green bricks.

clusterin peptide specifically binding to amyloid beta and uses thereof

Nº publicación: KR20260024607A 23/02/2026

Solicitante:

GACHON UNIV OF INDUSTRY ACADEMIC COOPERATION FOUNDATION [KR]
KOREA VETERANS HEALTH SERVICE [KR]
\uAC00\uCC9C\uB300\uD559\uAD50 \uC0B0\uD559\uD611\uB825\uB2E8,
\uD55C\uAD6D\uBCF4\uD6C8\uBCF5\uC9C0\uC758\uB8CC\uACF5\uB2E8

KR_20260024607_PA

Resumen de: KR20260024607A

본 발명은 아밀로이드 베타(amyloid beta, Aβ)와 특이적으로 결합하는 클러스터린(clusterin) 펩타이드 및 이의 용도에 관한 것이다. 본 발명의 아밀로이드 베타(Aβ)의 특이적으로 결합하는 클러스터린 유래 폴리펩타이드를 이용하는 경우, 아밀로이드 베타의 섬유화 및 올리고머화를 방지할 수 있으므로, 아밀로이드 베타 관련 퇴행성 신경질환의 치료 및 예방에 사용할 수 있으며, 뿐만 아니라, 클러스터린 베타 서브유닛(clusterin-β subunit)은 아밀로이드 베타 관련 퇴행성 신경질환의 진단을 위한 바이오마커로서 활용될 수 있다.

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