Si deseas distinguir tus productos, servicios o ambos de los de otra empresa, es posible que necesites una marca o nombre comercial. Descubre qué son, en qué consiste su procedimiento de registro y qué implica.
Información sobre los plazos de presentación de solicitudes de transformación de marcas de la Unión Europea en marca nacional española. Más información
Si tienes un nuevo dispositivo, producto o procedimiento que resuelva un problema técnico o tenga una ventaja práctica, existen distintas formas de protegerlo en España y en otros países. Descubre cómo hacerlo.
¿Tu innovación reside en la estética, la ornamentación o la apariencia de tu producto? Protégela mediante un diseño industrial. Descubre qué derechos confiere el registro y cómo realizar la tramitación.
Las indicaciones geográficas protegen el nombre de un producto originario de una zona geográfica, a la cual le debe una determinada calidad, reputación u otra característica. Descubre qué son, en qué consiste su procedimiento de registro y qué beneficios conceden.
Las patentes publicadas en todo el mundo son una valiosa fuente de información científica, técnica y comercial.
Si eres emprendedor/a o una empresa y quieres potenciar y mejorar la rentabilidad de tu negocio protegiendo de forma adecuada los activos intangibles de tu organización, en este espacio encontrarás lo necesario.
161
resultados
Última actualización
05/04/2026 [06:53:00]
Resultados 25 a 50 de 161
Resumen de: AU2026200326A1
Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines. an a n
Resumen de: US20260091125A1
The invention provides multifunctional system for the synchronized delivery of distinct immunoglobulins, in particular antibodies and antibody fragments to specific cancerous cells and tissues located outside of the brain. The multifunctional system is based on an inorganic core particle which is conjugated through a first polymeric linker to a first immunoglobulin; through a second polymeric linker to a second immunoglobulin; through a third polymeric linker to a penetration enhancing moiety; and to a fourth, monofunctional capping linker or spacer. Further provided are a process for preparation of the multifunctional system, pharmaceutical compositions comprising the multifunctional system and uses thereof in therapeutic and/or diagnostic methods.
Resumen de: US20260091107A1
The present invention is directed to a nucleic acid suitable for use in treatment or prophylaxis of an infection with a coronavirus, preferably with a Coronavirus SARS-CoV-2, or a disorder related to such an infection, preferably COVID-19. The present invention is also directed to compositions, polypeptides, and vaccines. The compositions and vaccines preferably comprise at least one of said nucleic acid sequences, preferably nucleic acid sequences in association a lipid nanoparticle (LNP). The invention is also directed to first and second medical uses of the nucleic acid, the composition, the polypeptide, the combination, the vaccine, and the kit, and to methods of treating or preventing a coronavirus Infection, preferably a Coronavirus infection.
Resumen de: US20260091127A1
Antimicrobial Janus nanoparticles (NPs) having distinct hydrophobic and polycationic surfaces are embedded in crosslinked polymers. These encapsulated Janus NPs have increased stabilization, to allow for long-term effectiveness. The encapsulated Janus NPs enhance traditional antibiotics and reduce the necessary dosage of those traditional antibiotics to inhibit growth of muti-drug resistant bacteria.
Resumen de: US20260091129A1
Provided are a nanocomposite for targeted degradation of a pathogenic protein, a preparation method therefor, and use thereof, which pertain to the technical field of nanobiological drugs. The nanocomposite for targeted degradation of the pathogenic protein is provided, which comprises a nanocarrier and a protein-targeting binding peptide grafted on the nanocarrier. The nanocarrier is a nanoassembly of maleimide-polyethylene glycol-polylactic acid and cationic lipids; on the other hand, the use of the nanocomposite in the preparation of drugs including an anti-tumor nanodrug and a Huntington's disease inhibiting drug is provided. The nanocomposite can simulate a key receptor protein in a selective autophagy pathway, so that the pathogenic protein to be degraded can be brought into an autophagosome to be degraded by means of an autophagy pathway, thereby effectively solving the problem that PROTACs cannot degrade large-molecular-weight protein aggregates and LYTACs cannot degrade cytoplasmic proteins.
Resumen de: US20260090997A1
This disclosure relates to lipid nanoparticles comprising nucleic acids encoding therapeutic proteins and uses in treating diseases such as cancer. In certain embodiments, this disclosure relates to methods of treating cancer or initiating, enhancing, or prolonging an anti-tumor response in a subject in need thereof comprising administering to the subject an effective amount of lipid nanoparticles as reported herein comprising a vector or nucleic acid encoding peptide based anticancer agent.
Resumen de: US20260090998A1
The disclosure relates to methods of using block copolymer nanoparticles for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to methods of using polymer nanoparticles for delivering nucleic acids for treating NF1.
Resumen de: US20260091126A1
Described herein is the preparation and use of amino acid-modified lipids for delivery of a small interfering RNA (siRNA), mRNA, miRNA, shRNA, or oligonucleotide via formation of lipid nanoparticles (LNPs) comprising the siRNA, mRNA, miRNA, shRNA, or oligonucleotide and the amino acid-modified lipid. Use of the described lipid nanoparticles to silence overexpression of oncogenes is described.
Resumen de: US20260091128A1
In one aspect, a block copolymer described herein comprises a hydrophilic block including oxazoline monomer or oxazine monomer, and a cationic block comprising monomer including a linear or branched polyamine side chain. In another aspect, a polyion complex comprises a block copolymer comprising a hydrophilic block including oxazoline monomer or oxazine monomer, and a cationic block comprising monomer including a linear or branched cationic polyamine side chain, and a negatively charged biomolecular species associated with the block copolymer. The negatively charged biomolecular species can comprise one or more nucleic acids, such as RNA, DNA, and/or other oligonucleotides.
Resumen de: MX2025013817A
The present disclosure relates to a process for the preparation of tolerizing immune modifying nanoparticles encapsulating antigens associated with primary biliary cholangitis (PBC), compositions comprising the particles and use thereof for the treatment of PBC.
Resumen de: AU2024250977A1
Provided herein are dispersible powder compositions comprising metal oxide particles and water, as well as methods of preparing dispersible powder compositions.
Resumen de: EP4717708A1
The purpose is to develop a crosslinked collagen hydrogel that can be easily manufactured and has high transparency, high safety, and low toxicity. It was found that a platinum-crosslinked collagen hydrogel that is colorless, transparent, and free of cytotoxicity can be manufactured by incubating collagen of a specific concentration and a platinum(II) complex of a specific concentration under conditions of a specific pH, and the present invention was accomplished. Specifically, the present invention provides a hydrogel that is composed of platinum-crosslinked collagen in which collagen is crosslinked by a platinum(II) complex and exhibits a visible light transmittance of 60% or more when it is measured at an absorbance of 400 nm in a cell having an optical path length of 10 mm.
Resumen de: CN121754505A
本发明公开了一种包埋虾青素的纳米颗粒及其制备方法，属于食品工业技术领域。本发明通过美拉德反应将亲水性的单糖接枝到鳕鱼鱼皮肽链上，使其具有优异的两亲性，而两亲性糖基化鳕鱼鱼皮肽通过疏水相互作用和空间自组装将虾青素包埋于纳米颗粒内部，形成了在内部空腔及特定功能的稳定纳米壳体结构，对疏水性物质虾青素能够高效包埋和递送；经本发明方法制备的对虾青素具有包埋效果的糖基化鳕鱼鱼皮肽，具有纳米级粒径和更大的比表面积，从而具有更高的包封率和装载量，而且具有流体力学直径小的优点，能够提高递送效率，在食品的营养素运输和功能性食品设计等方面有着巨大的应用价值。
Resumen de: CN121758745A
本发明涉及一种涉及医药技术领域，具体涉及阳离子聚合物及包含其的药物递送系统和应用。所述阳离子聚合物为含有环状二硫基团修饰的阳离子聚合物PEI，其中所述含有环状二硫基团如式（I）～（III）所示，本发明提供的聚合物能够作为药物载体，尤其是能作为核酸药物的载体，实现了肝外器官组织的靶向递送。
Resumen de: WO2025093038A1
The present invention relates to an immunogenic fragment of a p30 protein of an African swine fever virus, a recombinant protein, an immunogenic composition, and a use. The immunogenic fragment of the p30 protein of the African swine fever virus or a variant having immunogenicity can greatly improve the expression quantity, and can also reserve strong immunocompetence.
Resumen de: CN121758648A
本发明属于药物制剂、药物递送与疫苗技术领域，涉及一种烷基化香菇多糖的制备方法及其在LNP疫苗中的应用。本发明通过对香菇多糖进行烷基化修饰，使其能够高效溶于LNP中，适于脂质纳米颗粒（LNP）mRNA疫苗的制备。采用本发明的烷基化香菇多糖制备mRNA疫苗，可以将烷基化香菇多糖与mRNA协同装载/组装于同一脂质纳米递送体系,制备成抗原与佐剂一体化的疫苗体系，解决了现有技术中的难题，显著提升抗肿瘤免疫应答的强度与广度，具有高安全性，高效免疫激活，靶向性强的特点，可以广泛用于肿瘤预防/治疗效。
Resumen de: CN121754506A
本发明属于生物医药领域，涉及一种载药纳米囊泡及其制备方法和应用。该载药纳米囊泡包含：囊泡核，其包含能特异性靶向沉默NR1D1基因的siRNA；囊泡膜，其由红细胞膜、巨噬细胞膜、心磷脂、胆固醇与卵磷脂融合而成。该载药纳米囊泡能特异性靶向脓毒症免疫抑制阶段的巨噬细胞，并具有细胞内响应释放功能，其通过抑制NR1D1表达恢复BMAL1及IGF2BP2‑ATP6V1B2/ATP6V0c轴功能，重建巨噬细胞吞噬功能和溶酶体依赖的细菌清除能力，显著提高脓毒症免疫抑制模型动物的生存率并降低细菌载量。相比于传统的电穿孔法，本发明的制备方法显著提高了siRNA的包封率。
Resumen de: CN121754503A
本发明公开了一种纳米药物载体的改良装载方法，将重组人重链铁蛋白或其衍生物的载体加至高浓度脲溶液中，混合反应，使重组人重链铁蛋白壳解聚；加入药物，混合孵育；将孵育所得反应液用Tris缓冲溶液稀释到低浓度脲溶液中，反应8‑15h，使重组人重链铁蛋白壳复聚，最后通过Tris缓冲液用截留分子量 50 KD的膜包换液，得到装载完成的铁蛋白药物复合颗粒。本发明通过提供了“稀释后放置再换液，药质比优化”的制备方法，实现了蛋白回收率和载药量均明显提升的效果，蛋白回收率可达100%，载药量可达186 μg/mL。
Resumen de: WO2025093037A1
The invention relates to an immunogenic fragment of African swine fever virus p54 protein, a recombinant protein, an immunogenic composition and a use thereof. The provided immunogenic fragment of African swine fever virus p54 protein or a variant thereof with immunogenicity can improve the expression quantity while retaining the strong immunocompetence.
Resumen de: WO2025093042A1
Provided are an immunogenic fragment, a recombinant protein, and an immunogenic composition of the African swine fever virus E248R protein, as well as the use thereof. The immunogenic fragment of the African swine fever virus E248R protein or an immunogenic variant thereof can greatly improve expression levels while retaining strong immunological activity.
Resumen de: WO2025093039A1
Provided are an immunogenic fragment, a recombinant protein and an immunogenic composition of an African swine fever virus p15 protein and the use thereof. The immunogenic fragment of the African swine fever virus p15 protein or an immunogenic variant thereof has a higher expression level, and the strong immune activity is maintained.
Resumen de: CN121759475A
本发明公开了一种高稳定性mRNA构建体及其制备方法和用途，属于基因治疗技术领域。所述mRNA构建体从5'端到3'端依次包含：5'非翻译区、编码目的蛋白的开放阅读框、翻译增强与稳定元件A7S、3'非翻译区以及分段式Poly(A)尾。其中，所述分段式尾部由多个交替排列的腺苷酸片段和单个胞嘧啶间隔序列组成，且所述3'非翻译区与分段式Poly(A)尾之间不包含长度≥20 nt的连续腺苷酸序列。本发明通过特定分段式Poly(A)尾与A7S元件的协同作用抑制质粒扩增不稳定性并延缓mRNA去腺苷化降解以延长功能性半衰期。本发明提供的构建体及药物组合物可用于制备长效蛋白替代疗法等基因治疗药物。
Resumen de: CN121758411A
本发明涉及生物医药、基因治疗技术领域，特别是涉及一种可质子化阳离子脂质、核酸递送系统及其应用。本发明所述可质子化阳离子脂质具有如式（I）所示的结构，其末端含有羟基、氨基等可质子化基团。所述可质子化阳离子脂质可形成脂质纳米颗粒，用于包载多种核酸物质。所述脂质纳米颗粒核酸递送系统在体外具有高的细胞转染效率，在体内能靶向递送至肝脏等器官，实现高效的基因编辑。本发明提供的可质子化阳离子脂质所构建的脂质纳米颗粒包封率高、稳定性好、递送效率优异，在基因治疗与细胞工程领域具有广泛应用前景。
Resumen de: CN121754502A
基于微流控混合技术制备壳聚糖‑聚阴离子纳米颗粒的方法及应用，该方法包括：配制水相1为壳聚糖酸性水溶液，配制水相2为聚阴离子水溶液并加入表面活性剂；利用微流控设备及微流控混合器/芯片，使两相按设定总流速与流速比连续注入并在微尺度通道内快速混合，使壳聚糖与聚阴离子静电复合和/或离子交联形成纳米颗粒；对所得分散液过滤以去除凝聚体并收敛粒径分布。所述水相2还可包含阴离子药物或活性成分，优选核酸类物质，以制得负载型纳米颗粒。所得分散液可在0～8℃短期保存，或加入冷冻保护剂后冻干获得粉末。本发明工艺可连续化放大，提升粒径一致性与分散稳性。所述纳米颗粒用于递送所述阴离子药物或活性成分进入细胞或组织。
Nº publicación: CN121754557A 31/03/2026
Solicitante:
华南理工大学
Resumen de: CN121754557A
本发明属于医用材料的技术领域，公开了一种基于金属配位聚合物纳米粒子及其制备与应用。制备方法：1）将聚乙烯吡咯烷酮与铁盐在溶剂中混合，调节pH为8‑9，滴加姜黄素的乙醇溶液，滴加完后继续搅拌，获得铁基姜黄素；2）将单宁酸与铁基姜黄素反应，获得单宁酸配位铁基姜黄素；3）在反应介质中，将聚赖氨酸与单宁酸配位铁基姜黄素的反应，获得金属配位聚合物纳米粒子。本发明的方法简单，纳米粒子的组成成分均为天然材料，具有良好生物相容性，能够保留在生物组织内发挥作用，不会引起其他损伤。本发明的纳米粒子具有较好的抗氧化、抗菌和抗炎作用。所述纳米粒子用于制备治疗细菌性角膜炎或伤口感染的药物。
BOPI
Sede Electrónica
