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LastUpdate Última actualización 17/09/2025 [06:45:00]
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MINOR HISTOCOMPATIBILITY ANTIGEN MARKERS ASSOCIATED WITH GRAFT VERSUS LEUKEMIA EFFECT AND USES THEREOF

NºPublicación:  WO2025174664A1 21/08/2025
Solicitante: 
DANA FARBER CANCER INST INC [US]
THE GENERAL HOSPITAL CORP [US]
THE BROAD INST INC [US]
DANA-FARBER CANCER INSTITUTE, INC,
THE GENERAL HOSPITAL CORPORATION,
THE BROAD INSTITUTE, INC
WO_2025174664_A1

Resumen de: WO2025174664A1

Minor histocompatibility antigens (mHAgs) associated with graft versus leukemia (GvL) clinical outcomes identified by single nucleotide polymorphisms (SNPS) and uses thereof are described.

NOVEL TUMOR-SPECIFIC ANTIGENS FOR MYELOID LEUKEMIA AND USES THEREOF

Nº publicación: EP4602051A1 20/08/2025

Solicitante:

UNIV MONTREAL [CA]
Universit\u00E9 de Montr\u00E9al

WO_2024077376_A1

Resumen de: WO2024077376A1

Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly because of the lack of actionable immune targets. Novel tumor-specific antigens (TSAs) shared by a large proportion of AML cells are described herein. Most of the TSAs described herein derives from aberrantly expressed unmutated genomic sequences, such as intronic and intergenic sequences, which are not expressed in normal tissues. Nucleic acids, compositions, cells and vaccines derived from these TSAs are described. The use of the TSAs, nucleic acids, compositions, cells and vaccines for the treatment of myelodysplastic syndrome (MDS) or leukemia such as AML is also described.

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