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Resultados 57 resultados
LastUpdate Última actualización 04/02/2026 [06:45:00]
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Solicitudes publicadas en los últimos 30 días / Applications published in the last 30 days
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Bispecific Anti-BCMA x Anti-CD3 Antibodies and Uses Thereof

NºPublicación:  US20260008862A1 08/01/2026
Solicitante: 
REGENERON PHARMACEUTICALS INC [US]
Regeneron Pharmaceuticals, Inc
US_20260008862_PA

Resumen de: US20260008862A1

B-cell maturation antigen (BCMA) is expressed on malignant plasma cells. The present invention provides novel bispecific antibodies (bsAbs) that bind to both BCMA and CD3 and activate T cells via the CD3 complex in the presence of BCMA-expressing tumor cells. In certain embodiments, the bispecific antigen-binding molecules of the present invention are capable of inhibiting the growth of tumors expressing BCMA. The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced BCMA-targeted immune response is desired and/or therapeutically beneficial. For example, the bispecific antibodies of the invention are useful for the treatment of various cancers, including multiple myeloma.

TARGETING CHROMATIN REGULATORS INHIBITS LEUKEMOGENIC GENE EXPRESSION IN NPM1 MUTANT LEUKEMIA

NºPublicación:  US20260007675A1 08/01/2026
Solicitante: 
MEMORIAL SLOAN KETTERING CANCER CENTER [US]
MEMORIAL SLOAN KETTERING CANCER CENTER
US_20260007675_A1

Resumen de: US20260007675A1

Disclosed are methods for inhibiting proliferation of or inducing apoptosis in certain leukemia cells or both. The methods comprise contacting a leukemia cell exhibiting an NPM1 mutation with a pharmacologic inhibitor of interaction between MLL and menin. More broadly, disclosed are methods for treating a susceptible leukemia using pharmacologic inhibition of Menin-MLL interaction. Also disclosed are methods for treating such leukemias using inhibition of Menin-MLL interaction in combination with DOT1L inhibition.

ANTI-SCUBE1 ANTIBODY HAVING HIGH INTERNALIZATION CAPACITY IN LEUKEMIA

NºPublicación:  US20260007767A1 08/01/2026
Solicitante: 
ACAD SINICA [TW]
ACADEMIA SINICA
US_20260007767_PA

Resumen de: US20260007767A1

The present disclosure relates to anti-SCUBE1 antibodies, antigen-binding fragments thereof, and antibody drug conjugates (ADCs), as well as methods of treating and/or preventing SCUBE1-expressing cancers.

COMBINATION DRUG CONTAINING CD20/CD47 BLOCKING BIFUNCTIONAL FUSION PROTEIN, AND USE THEREOF

NºPublicación:  EP4674432A1 07/01/2026
Solicitante: 
SHANGHAI JMT BIO TECH CO LTD [CN]
Shanghai JMT-Bio Technology Co., Ltd
EP_4674432_A1

Resumen de: EP4674432A1

Provided are a method and a use for treating cancers by using a CD20/CD47 double-blocking bifunctional fusion protein in combination with a bifunctional alkylating agent, in particular a method and a use for treating cancers (especially non-Hodgkin lymphoma) by using a CD20/CD47 double-blocking bifunctional fusion protein in combination with bendamustine or a salt thereof.

METHODS FOR TREATING MULTIPLE MYELOMA

NºPublicación:  MX2025012459A 07/01/2026
Solicitante: 
JANSSEN BIOTECH INC [US]
JANSSEN BIOTECH, INC
KR_20250173553_PA

Resumen de: MX2025012459A

Embodiments of the present invention relate to methods of treating multiple myeloma in a subject in need thereof, comprising administering therapeutically effective amounts of a BCMAxCD3 bispecific antibody and a GPRC5DxCD3 bispecific antibody to the subject.

METHODS FOR TREATING MULTIPLE MYELOMA

NºPublicación:  MX2025014342A 07/01/2026
Solicitante: 
JANSSEN BIOTECH INC [US]
JANSSEN BIOTECH, INC
CN_121311245_A

Resumen de: MX2025014342A

Embodiments of the present invention relate to methods of treating multiple myeloma in a subject in need thereof, comprising administering therapeutically effective amounts of a GPRC5DxCD3 bispecific antibody on a monthly dosing schedule.

MACROPHAGE SIGNATURES FOR DIAGNOSTIC AND THERAPEUTIC METHODS FOR LYMPHOMA

Nº publicación: MX2025014558A 07/01/2026

Solicitante:

GENENTECH INC [US]
GENENTECH, INC

CN_121285742_PA

Resumen de: MX2025014558A

The present invention provides diagnostic methods, therapeutic methods, and compositions for the treatment of lymphoma (e.g., a diffuse large B-cell lymphoma (e.g., a germinal-center B-cell- like or activated B-cell-like diffuse large B-cell lymphoma). The invention is based, at least in part, on the discovery that macrophage biomarkers are useful in methods of identifying, diagnosing, or predicting the therapeutic efficacy of treatment with an anti-CD79b immunoconjugate (e.g., polatuzumab vedotin) and an anti-CD20 antibody (e.g., obinutuzumab or rituximab).

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