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116
resultados
Última actualización
02/04/2026 [07:20:00]
Resultados 25 a 50 de 116
Resumen de: CN121554580A
本发明公开了鼠疫抗体Fm3及其应用。本发明为本领域提供了一种全新的靶向鼠疫菌F1蛋白的鼠源单克隆抗体，所述抗体能够有效中和鼠疫强毒株和耐药株，具有较好的亲和力和特异性，能够有效抵抗致死剂量的强毒株和耐药株的攻击。本发明为本领域开发鼠疫强毒株和耐药株的治疗药物提供了新策略，具有良好的应用前景。
Resumen de: WO2025021712A1
The present invention relates to immunogenic compositions comprising antigens from Salmonella enterica serovar Typhimurium (S. Typhimurium), Salmonella enterica serovar Enteritidis (S. Enteritidis), and Salmonella enterica serovar Typhi (S. Typhi). The present invention further relates to methods and uses of compositions comprising GMMA for boosting an immune response to an S. Typhi antigen, vaccines comprising the immunogenic compositions and methods and uses of the immunogenic compositions.
Resumen de: WO2026039487A1
The invention relates to small molecule compounds that are useful as antimicrobial agents, pharmaceutical compositions comprising the compounds, and the use of the compounds in the treatment of subjects with microbial infections.
Resumen de: US20260048111A1
The present disclosure relates to the technical field of medicine, and in particular to a pharmaceutical composition, preparation method and use thereof. The pharmaceutical composition includes a first active ingredient, a second active ingredient, and a pharmaceutically acceptable carrier or excipient. The first active ingredient is a microbial agent, including one or more of Staphylococcus aureus, Bordetella pertussis, diphtheria toxoid, tetanus toxoid, Salmonella typhi, and Salmonella paratyphi. The second active ingredient includes polyinosinic acid, polycytidylic acid, and vitamin. The pharmaceutical composition of the present disclosure pertains to an artificial active immunotherapy for tumors. It can “stimulate” the entire immune system, making the therapy of using bacteria to activate the human immune system to kill cancer cells highly stable and reliable. This composition can significantly save and prolong the lives of cancer patients while exhibiting extremely high safety, minimal toxic side effects, and low production costs.
Resumen de: US20260048107A1
A vaccine is disclosed which comprises a pharmaceutically acceptable carrier and Gramnegative bacteria, genetically modified to express: at least one disease-associated antigen, linked to a signal sequence belonging to a type II secretion system; and the at least one disease-associated antigen linked to a signal sequence belonging to a type III secretion system. Uses thereof are also disclosed.
Resumen de: US20260048109A1
Provided herein are methods for vaccinating a subject against a Salmonella species, including typhoidal and non-typhoidal Salmonella species and serovars thereof with an Escherichia coli J5 dLOS/OMP vaccine. The vaccine is cross-reactive with the lipopolysaccharide conserved inner core region of the Salmonella species and cross-protective with the non-typhoidal Salmonella species. Vaccination reduces the likelihood of or prevents the onset of a salmonella infection. Also provided is a method of immunizing against antimicrobial resistant Salmonella species by complementing the J5 dLOS/OMP vaccine with a Salmonella species-specific vaccine.
Resumen de: EP4650361A1
The present invention relates to an arginine fluorescent optical probe. Specifically, the present invention provides an arginine-sensitive polypeptide, wherein the arginine-sensitive polypeptide is a variant of an arginine binding protein, and formula (1) thereof has a sequence as shown in SEQ ID NO: 1 and has mutations at one, two, or three or more sites selected from the following. Compared with a probe formed by a wild arginine-sensitive polypeptide, the fluorescent probe of the present invention has greater dynamic changes in fluorescence and better specificity, and can be used for the high-throughput and quantitative detection of arginine inside and outside of cells.
Resumen de: WO2025021712A1
The present invention relates to immunogenic compositions comprising antigens from Salmonella enterica serovar Typhimurium (S. Typhimurium), Salmonella enterica serovar Enteritidis (S. Enteritidis), and Salmonella enterica serovar Typhi (S. Typhi). The present invention further relates to methods and uses of compositions comprising GMMA for boosting an immune response to an S. Typhi antigen, vaccines comprising the immunogenic compositions and methods and uses of the immunogenic compositions.
Resumen de: CN121522153A
本发明公开了肠道菌群代谢物水杨酸作为大肠杆菌性犊牛腹泻预测标志物的应用。通过非靶向代谢组学技术从腹泻犊牛粪便中筛选出显著上调的代谢物水杨酸，并在一组新的独立样本中，通过ELISA试验验证了腹泻组犊牛粪便水杨酸浓度显著高于健康组。ROC曲线分析表明，SA预测大肠杆菌性犊牛腹泻的曲线下面积（AUC）为0.8148，具有良好的预测能力。本发明提供了一种非侵入性、廉价、快速且特异性强的预测方法，可用于大肠杆菌性犊牛腹泻的早期预警和辅助诊断，对指导临床精准用药、降低犊牛死亡率具有重要意义。
Resumen de: CN121517554A
本发明公开了鼠疫抗体Fm25及其应用，所述鼠疫抗体Fm25是一种靶向鼠疫菌F1蛋白的抗体，其重链可变区中的HCDR1‑3分别如SEQ ID NO:1‑3所示，轻链可变区中的LCDR1‑3分别如SEQ ID NO:5‑7所示，其对F1蛋白具有较高的结合活性和较好的结合特异性，能够用于鼠疫菌感染的检测和治疗中，对防控鼠疫具有重要意义。
Resumen de: CN121517526A
本发明属于生物技术领域，涉及一种沙门菌靶向抗菌肽Yisi‑1及其应用。所述靶向抗菌肽Yisi‑1的氨基酸序列为丙氨酸‑异亮氨酸‑赖氨酸‑甘氨酸‑缬氨酸‑赖氨酸‑丙氨酸‑甘氨酸‑异亮氨酸‑精氨酸‑亮氨酸‑甘氨酸‑赖氨酸‑赖氨酸‑甘氨酸‑亮氨酸‑精氨酸‑丙氨酸，该靶向抗菌肽Yisi‑1的分子量为1836.3Da，等电点为12.1，带6个正电荷，两亲性高，对金黄色葡萄球菌、大肠杆菌、奇异变形杆菌、绿脓杆菌、白色念珠菌等均没有抑菌活性，仅对沙门菌具有抑菌活性，对鸡红细胞具有较低的溶血性。本发明的靶向抗菌肽Yisi‑1有望成为一种新的抗生素替代物，将在预防、诊断、治疗和鉴定沙门菌及其感染中具有良好的应用前景。
Resumen de: CN121517555A
本发明公开了一种结合K88ac的特异性纳米抗体、制备方法及其应用，属于生物工程技术领域。所述纳米抗体命名为NBK88，其氨基酸序列如SEQ ID NO:2所示。同时公开了其编码基因、重组表达载体、宿主细胞及制备方法与应用。本发明公开的纳米抗体NBK88对K88ac抗原具有纳摩尔级的高亲和力（KD=1.733×10‑7 M），使其在识别过程中兼具高灵敏度与高特异性；基于该抗体构建的检测方法能够有效捕获样本中微量K88ac蛋白，即使在低菌量或复杂样本中也可实现早期准确检测，显著降低检测限；同时，其与K88ac的结合高度特异，在K88阳性与阴性菌株间呈现统计学显著差异，可有效避免与其他ETEC血清型或肠道菌群的交叉反应，杜绝假阳性，确保检测结果精准可靠。
Resumen de: CN121522155A
本发明公开了一种巴氏杀菌乳中沙门氏菌的检测方法，涉及食品检测技术领域，本发明通过构建铂基聚合物纳米酶复合探针，结合免疫磁珠分离与信号放大策略，提出了一种适用于巴氏杀菌乳中沙门氏菌的一步法快速高灵敏检测方法。本发明基于铂基聚合物纳米酶优异的类过氧化物酶活性，该复合探针可在低浓度目标菌存在下催化显色底物产生强信号放大效应，实现在巴氏杀菌乳基质中对沙门氏菌的低至10CFU/mL的检测限，较传统培养法及部分现有免疫学方法灵敏度提升一至两个数量级，显著增强了低污染水平沙门氏菌的检出能力。
Resumen de: US20260041735A1
The present disclosure relates to a recombinant expression vector for secretion of interleukin-21 and an attenuated Salmonella strain transformed therewith, and provides: a recombinant expression vector comprising an flgM gene and an interleukin-21 gene; an attenuated Salmonella strain transformed therewith; and a pharmaceutical composition for cancer treatment, comprising the attenuated Salmonella strain.
Resumen de: WO2025003119A1
The invention relates to a method for detecting and confirming at least one Shiga toxin-producing Escherichia Coli (STEC) which may be present in a sample comprising enterobacteria, comprising the following steps: - performing lysis of the sample, enabling lysis of the STECs in order to obtain a solution comprising the nucleic acids thereof; - bringing the solution of nucleic acids into contact with primers, making it possible to amplify at least the stx1 and/or stx2 gene or gene fragment; - if at least one of the stx1 and/or stx2 genes or gene fragments is amplified, part of the sample is deposited on an agar reaction medium comprising ■ at least one toxin inducer, ■ at least one agglutinating conjugate formed by at least one binding partner specific to the STX1 protein and/or at least one binding partner specific to the STX2 protein, which binding partner(s) is (are) coupled to a nanoparticle; - detecting and confirming the presence of at least one STEC by the appearance of a halo on the agar around the STEC.
Resumen de: WO2025003117A1
The present invention relates to a gelled reaction medium for detecting, identifying, and/or isolating at least one Shiga toxin-producing strain of E. coli, the reaction medium comprising: - at least one toxin inducer, - at least one agglutinating conjugate comprising at least one specific binding partner of STX1 and/or at least one specific binding partner of STX2, coupled to a nanoparticle; - a concentration gradient of a compound for inhibiting non-target bacteria. The present invention also relates to the associated method for detecting and/or isolating Shiga toxin-producing E. coli which is likely to be present in a sample comprising enterobacteria.
Resumen de: EP4692335A1
An aim of the present disclosure is: (i) to provide a novel bacteriophage having bacteriolytic activity against bacteria of the genus Salmonella, such as S. Enteritidis, or a bacteriolytic agent consisting of the same; (ii) to provide a bacteriophage having a wide host range for bacteria of the genus Salmonella, or a bacteriolytic agent consisting of the same; (iii) to provide a host-specific bacteriophage or an effective Salmonella bacteriolytic agent consisting of the same; or (iv) provide a bacteriophage capable of effectively controlling S. Typhimurium, and in particular, multidrug-resistant S. Typhimurium, or a bacteriolytic agent consisting of the same. The present disclosure provides: a bacteriophage having a specific genomic DNA sequence; a Salmonella bacteriolytic agent consisting of the bacteriophage; and a composition comprising the same.
Resumen de: EP4692334A1
An aim of the present invention is to provide a bacteriophage having a wide host range for bacteria of the genus Salmonella. The present invention is a bacteriophage with bacteriolytic activity against bacteria of the genus Salmonella, in which the bacteriophage has a genomic DNA sequence comprising a gene encoding a tail tip protein consisting of a specific amino acid sequence.
Resumen de: CN121476591A
本发明具体涉及一种用于检测大肠杆菌的双模态生物传感器检测试剂盒及制备方法，属于食品安全检测技术领域。双模态生物传感器检测试剂盒由网状靶向磁珠和生物传感器检测试剂组成；生物传感器检测试剂为适配体修饰的铜金属掺杂碳点溶液，适配体为氨基化适配体。本发明的双模态传感器提供的双信号可以互相校准，避免单信号输出的偶然性误差，还可根据不同的场景选择优势检测模态；以网状PGA结构为中间体包覆四氧化三铁磁珠，高负载的网状结构为识别元件提供更多结合位点进一步增强了磁分离技术的捕获效率；增强磁分离技术驱动的双金属靶向改性碳点在检测大肠杆菌O157:H7时具有良好的检测性能，在食品基质中捕获低浓度目标菌的效率可达90%以上。
Resumen de: CN121471909A
本发明属于食品安全检测技术领域，具体涉及一种叶酸‑邻苯二胺共掺杂碳量子点、大肠埃希氏菌O157:H7检测探针、检测试剂及应用。叶酸‑邻苯二胺共掺杂碳量子点由叶酸和邻苯二胺加热反应制得。基于本发明的叶酸‑邻苯二胺共掺杂碳量子点的检测探针或检测试剂对大肠埃希氏菌O157:H7进行检测，检测限低、特异性优异，实用性强。
Resumen de: CN121472232A
本发明涉及生物技术领域，具体公开了一种阪崎克罗诺杆菌核酸适配体及其在制备生物传感器中的应用。本发明针对阪崎克罗诺杆菌MipA蛋白设计了DNA序列如SEQ ID No:1所示的核酸适配体，5’端氨基修饰。该适配体可用于构建荧光淬灭型生物传感器，包括荧光探针（枸橼酸二铵、硫脲、正硅酸甲酯及二氧化铈合成荧光纳米粒子，第一适配体羧基修饰）和淬灭探针（柠檬酸还原金纳米粒子，第二适配体巯基修饰，SEQ ID No:2）。与传统方法相比，筛选效率显著提升，检测时间<1h，抗干扰强，亲和常数13.28nM，适用于婴幼儿食品快速监测，经济成本降低至少40%。
Resumen de: US20260035440A1
The invention provides anti-ETEC adhesin protein antibodies and methods of using the same.
Resumen de: WO2026030756A2
The composition and methods of treatment disclosed or contemplated herein include compositions and methods of treatment for liver-related diseases. The overall treatment strategy would involve the identification of a target protein or receptor within the liver that is responsible for ongoing liver injury. The strain of orally administered Salmonella Typhimurium that colonizes the liver would be engineered to secrete a particular protein or nanobody that would stop and/or reverse the progressive hepatic disease
Resumen de: WO2026027798A1
A yeast biomass composition is formed by culturing a strain of yeast in a substrate such as whey permeate to product a yeast broth, dewatering the broth to produce yeast biomass, and hydrolysing the yeast biomass. The yeast biomass composition finds utility as a feed additive for broiler chickens to reduce the adherence of pathogenic bacteria like Salmonella and E.coli to the gut wall of the chickens, thereby reducing intestinal stress and improving life daily weight gain in the chickens.
Nº publicación: CN121454057A 03/02/2026
Solicitante:
华南理工大学
Resumen de: CN121454057A
本发明公开了一种多功能纳米材料荧光‑比色双模式食源性致病菌检测与杀灭方法及其系统。该方法利用具有纳米酶活性的金属有机框架材料（MIL‑53(Fe)）作为信号开关与发生器，联合荧光指示与光热杀菌单元的碳纳米点（CDs）共同构成了基础平台，利用适配体对纳米酶活性位点的掩蔽与目标菌触发下的竞争性释放为核心机制，激活比色与比率荧光双信号通道，实现自验证的高精度检测；并利用体系中的CDs作为光热元件，在检测后实现原位光热杀菌。通过更换适配体即可切换检测对象的“平台化”设计，展现了良好的通用性和应用前景，为食源性致病菌的检测与消除提供了灵敏、高效的新策略。
BOPI
Sede Electrónica
