Si deseas distinguir tus productos, servicios o ambos de los de otra empresa, es posible que necesites una marca o nombre comercial. Descubre qué son, en qué consiste su procedimiento de registro y qué implica.
Información sobre los plazos de presentación de solicitudes de transformación de marcas de la Unión Europea en marca nacional española. Más información
Si tienes un nuevo dispositivo, producto o procedimiento que resuelva un problema técnico o tenga una ventaja práctica, existen distintas formas de protegerlo en España y en otros países. Descubre cómo hacerlo.
¿Tu innovación reside en la estética, la ornamentación o la apariencia de tu producto? Protégela mediante un diseño industrial. Descubre qué derechos confiere el registro y cómo realizar la tramitación.
Las indicaciones geográficas protegen el nombre de un producto originario de una zona geográfica, a la cual le debe una determinada calidad, reputación u otra característica. Descubre qué son, en qué consiste su procedimiento de registro y qué beneficios conceden.
Las patentes publicadas en todo el mundo son una valiosa fuente de información científica, técnica y comercial.
Si eres emprendedor/a o una empresa y quieres potenciar y mejorar la rentabilidad de tu negocio protegiendo de forma adecuada los activos intangibles de tu organización, en este espacio encontrarás lo necesario.
117
resultados
Última actualización
19/08/2026 [08:36:00]
Resultados 25 a 50 de 117
Resumen de: US20260201361A1
0000 The invention relates to guided nucleases, CRISPR/Cas systems, crRNAs, single gRNAs, vectors, methods and pharmaceutical compositions, for example for targeting sporulating bacteria, or for targeting C difficile, Salmonella, E coli or Streptococcus.
Resumen de: US20260200994A1
This application relates to compositions and methods used to treat animals with at least one microbial protein, such as a flagellin protein. In embodiments, application relates to compositions and methods to treat animals with a fusion protein comprising at least one adjuvant protein, such as a flagellin protein. In embodiments, the composition further includes at least one adjuvantic protein fused with at least one antigen protein, and the fusion protein is expressed in diatoms.
Resumen de: AU2026205168A1
Synthetic binding agents for reducing the fraction of targets that can permeate through mucus and/or freely divide, and methods of reducing mucosal permeation and/or free division of a target using these synthetic binding agents. un u n
Resumen de: CN122351451A
本发明提供了一种预防幽门螺杆菌感染的组合物及制备方法和应用。所述组合物包括外膜囊泡混合物和嗜黏蛋白阿克曼氏菌菌液；所述外膜囊泡混合物由沙门菌突变株QS0074的外膜囊泡和大肠杆菌E. coli Nissle 1917的外膜囊泡按照重量比2:1组成；所述外膜囊泡混合物和嗜黏蛋白阿克曼氏菌菌液的重量体积比为1mg:1mL。本发明所得组合物在攻毒试验中，显著优于对照组，具有高效的预防幽门螺杆菌感染的效果。同时，本发明的组合物各组分之间在诱导小鼠产生分泌性IgA水平和分泌性IgA水平以及诱导小鼠产生抵抗幽门螺杆菌感染能力方面，均产生了明显的协同作用，具有良好的应用前景。
Resumen de: US20260191946A1
This invention relates to the field of biomedicine and specifically to a porcine interferon-like recombinant protein and its applications. By constructing and screening a PoIFN-α DNA shuffling bacterial library, a highly active recombinant protein Porferon was obtained. Porferon exhibits potent anti-infective activity against a broad range of porcine pathogens, including viruses, bacteria, and parasites. Its biological activity is significantly superior to that of natural porcine interferon. As such, Porferon can be used in the development of therapeutics for the prevention or treatment of infectious diseases in pigs, offering a novel and effective solution for clinical applications in veterinary medicine.
Resumen de: WO2026148245A1
The present disclosure relates to microbials for use in E. coli, Salmonella, Enterococcus and/or Clostridium inhibition in animals and their environment. More particularly, the present disclosure relates to isolated Bacillus strains MDG-844 (NRRL No. B-68469), MDG-UF7 (NRRL No. B-68470), MDG-UC25 (NRRL No. B-68471), and MDG-I60 (NRRL No. B-68472), and strains having all of the identifying characteristics of these strains, for a use comprising the above-mentioned use.
Resumen de: CN122326485A
The invention discloses a plant lactobacillus and application thereof, and belongs to the technical field of microorganisms. The preservation number of the strain is CGMCC (China General Microbiological Culture Collection Center) No. 33864. The strain has good tolerance to gastrointestinal fluid and cholate and has no hemolytic activity. The concentrated cell-free supernate prepared from the strain can inhibit salmonella, including inhibiting growth of salmonella, killing bacteria and inhibiting or removing biological membranes of salmonella. Animal experiments show that the strain and the concentrated cell-free supernate thereof can prevent salmonella infection, relieve weight loss caused by infection, maintain intestinal barrier integrity, reduce the level of proinflammatory factors, relieve tissue damage, improve expression of tight junction protein and mucoprotein of colon, promote generation of short-chain fatty acid and recover intestinal flora structure. The invention also provides a microbial preparation containing the strain and/or a concentrated cell-free supernatant of the strain. The strain and the microbial preparation can be used for preparing products for resisting salmonella, preventing salmonella infection or improving intestinal health.
Resumen de: CN122326641A
A method for increasing the yield of salmonella outer membrane vesicles comprises the following steps: constructing salmonella recombinant bacteria with a tolR gene knocked out, and obtaining the salmonella recombinant bacteria after the tolR gene in wild type salmonella enteritidis sdc-11 is knocked out; and culturing the salmonella recombinant bacteria of which the tolR gene is knocked out in an LB culture medium added with glycine at 30-39 DEG C for 2-24 hours, and then collecting the outer membrane vesicles. According to the invention, a salmonella strain sdc-11 delta tolR of which the tolR gene is knocked out is constructed, and the yield of OMVs is increased by 1.6 times; on the basis, culture conditions of the strain are optimized, glycine is added into a culture medium of the strain, the yield of the OMVs is further increased by 8.8 times, and it is proved that culture is conducted for 18 h at the temperature of 37 DEG C, which is the optimal production condition of the OMVs. Compared with a wild strain sdc-11, the shape and the particle size of the OMVs secreted by the recombinant strain under the conditions are not obviously different from those of the OMVs secreted by the wild strain.
Resumen de: CN122326781A
The invention relates to the field of gene detection, in particular to a food-borne pathogenic bacterium single-tube multiple detection sequence combination based on an asymmetric ratio and melting curve, a kit, a detection method and application. The invention provides a sequence combination for detecting food-borne pathogenic bacteria. The sequence combination comprises a forward primer, a reverse primer, a specific probe and a reverse partial complementary melting curve probe. The invention further provides a kit for detecting the food-borne pathogenic bacteria, the problems of system competitive inhibition and cross mismatch under a complex genetic background are solved by adjusting an asymmetric ratio, and a detection method for detecting type 5 diarrheagenic Escherichia coli, salmonella, listeria monocytogenes and staphylococcus aureus through a single tube is constructed. The method does not need to add a complex hardware channel or expensive detection equipment, has the advantages of high detection flux, strong specificity and low instrument cost, and is suitable for application and popularization of low-resource grass-roots institutions, customs and first-line food safety supervision.
Resumen de: CN122325803A
The invention discloses a chitosan antibacterial film preparation method, which comprises: respectively preparing a berberine aqueous solution and a tannic acid aqueous solution, dropwise adding the berberine aqueous solution into the tannic acid aqueous solution to form a mixed solution, stirring and heating the mixed solution to obtain a suspension, and freeze-drying the suspension to obtain berberine-tannic acid nanoparticles; and mixing an acetic acid aqueous solution of chitosan with the berberine-tannic acid nanoparticles, and forming a film to obtain the chitosan antibacterial film loaded with the berberine-tannic acid nanoparticles. The prepared chitosan antibacterial film is low in moisture content and swelling degree, strong in ultraviolet shielding force and high in transparency, has relatively strong inhibitory activity on staphylococcus aureus and salmonella typhimurium, and can better meet the food fresh-keeping requirement.
Resumen de: CN122320124A
The invention belongs to the technical field of feed additives, and particularly relates to a feed additive for reducing antibiotic resistance genes in animal waste as well as a preparation method and application of the feed additive. The feed additive comprises the following components in percentage by mass: 10%-15% of rosmarinic acid, 10%-15% of 5-O-caffeoylshikimic acid, 8%-12% of herba lycopi flavone, 7%-10% of tea polyphenol, 7%-10% of DL-alpha-tocopherol, 22%-28% of hydroxypropyl-beta-cyclodextrin, 18%-22% of a microcapsule wall material, 0.8%-1.2% of EDTA-2Na (Ethylene Diamine Tetraacetic Acid) and 1.5%-2.2% of a citric acid-sodium citrate buffer solution. The feed additive disclosed by the invention not only has definite bacteriostatic activity on escherichia coli and salmonella, but also can improve the growth performance of weaned piglets, reduce the diarrhea rate of the weaned piglets and the abundance of drug-resistant genes in excrement of the weaned piglets, and has a good application prospect.
Resumen de: WO2025003117A1
The present invention relates to a gelled reaction medium for detecting, identifying, and/or isolating at least one Shiga toxin-producing strain of E. coli, the reaction medium comprising: - at least one toxin inducer, - at least one agglutinating conjugate comprising at least one specific binding partner of STX1 and/or at least one specific binding partner of STX2, coupled to a nanoparticle; - a concentration gradient of a compound for inhibiting non-target bacteria. The present invention also relates to the associated method for detecting and/or isolating Shiga toxin-producing E. coli which is likely to be present in a sample comprising enterobacteria.
Resumen de: US20260183344A1
0000 A genetically modified Salmonella cell (GMSC) engineered to exhibit specific targeting to cells and regulated delayed lysis in vivo, the GMSC comprising a first heterologous nucleic acid that encodes a first gene product that causes the GMSC to be selectively localized to and/or internalized by a target cell in vivo and a second heterologous nucleic acid that encodes a second gene product that facilitates killing of the target cells following internalization.
Resumen de: US20260183346A1
0000 The composition and methods of treatment disclosed or contemplated herein include compositions and methods of treatment for liver-related diseases. The overall treatment strategy would involve the identification of a target protein or receptor within the liver that is responsible for ongoing liver injury. The strain of orally administered Salmonella Typhimurium that colonizes the liver would be engineered to secrete a particular protein or nanobody that would stop and/or reverse the progressive hepatic disease
Resumen de: WO2025042889A1
The present disclosure provides formulations, kits, and vaccines directed to immunization of animals against Salmonella. Methods of usng the formulations, kits, and vaccines for protection of avians against one or more species of Salmonella are also provided.
Resumen de: WO2024254147A1
The present disclosure relates, in part, to a polypeptide of formula (I), or a salt or solvate thereof, and a vaccine composition thereof further comprising at least one pharmaceutically acceptable excipient. The present disclosure further relates to isolated mRNA and/or isolated polynucleotides encoding the polypeptide of formula (I), vectors and/or LNPs comprising the same, and pharmaceutical compositions thereof. The present disclosure further relates to methods of treating, preventing, and/or ameliorating a bacterial infection, and/or generating immunity to infection by one or more pathogenic bacteria, in a subject in need thereof, the method comprising administering to the subject at least one composition of the present disclosure. In certain embodiments, the bacterial infection is a urinary tract infection, sepsis (e.g, neonatal sepsis), or pneumonia.
Resumen de: CN122303462A
The invention provides a primer/probe composition for simultaneously detecting shigella and salmonella, a kit and application, and belongs to the technical field of gene detection. The invention comprises a primer/probe set for detecting shigella and a primer/probe set for detecting salmonella. The invention has the advantages of high detection sensitivity, strong specificity, high dual synchronous detection efficiency, good repeatability, good stability and low pollution risk, and is especially suitable for low-load sample detection and rapid screening of monkey group samples.
Resumen de: CN122297663A
本发明涉及生物蛋白应用技术领域，公开了鞭毛蛋白高变区H作为分子内佐剂在制备疫苗中的应用。鞭毛蛋白高变区H的氨基酸序列如SEQ ID NO.3所示，编码鞭毛蛋白高变区H的基因的核苷酸序列如SEQ ID NO.4所示。本发明还公开了含有编码鞭毛蛋白高变区H的基因的表达盒、重组载体、重组细胞或重组菌。本发明采用上述的鞭毛蛋白高变区H作为分子内佐剂在制备疫苗中的应用，本发明将鞭毛蛋白高变区H与抗原表位相连接得到融合蛋白，与现有技术相比，融合蛋白的可溶性和活性得到提高，同时本发明克服了现有大肠杆菌表达系统中包涵体的表达形式，后期不需要重新折叠组装，精简了疫苗制备工艺。
Resumen de: CN122303118A
The invention discloses engineered attenuated salmonella VNP-SNase as well as a preparation method and application thereof, and relates to a method and a composition for treating various solid tumors or metastatic tumors. Specifically, engineered attenuated salmonella capable of expressing and secreting SNase is collected to a tumor microenvironment by utilizing tumor targeting of the engineered attenuated salmonella, neutrophil extracellular trapping nets (NETs) in a tumor are specifically degraded, killing of the NETs on the salmonella is weakened, tumor colonization of the salmonella is improved, meanwhile, tumor promotion and immunosuppression caused by the NETs are improved, and the salmonella can be effectively degraded. And bacteria are effectively prevented from being miss-targeted into normal visceral organs. By releasing SNase to activate/regulate the immune system to directly/indirectly inhibit tumors, the polypeptide can act as an effective immune effector.
Resumen de: CN122297427A
The invention discloses a multilayer microsphere for preventing and/or treating bacterial diarrhea as well as a preparation method and application thereof, and relates to the technical field of biological medicines. The multi-layer microsphere is of a three-layer core-shell structure, lactobacillus plantarum and sodium butyrate are loaded on an inner core, a middle layer is a chitosan coating layer, and an outer layer is a sodium alginate coating layer. Research finds that lactobacillus plantarum and sodium butyrate have a remarkable synergistic bacteriostatic effect, and proliferation of pathogenic escherichia coli and salmonella can be efficiently inhibited. In-vivo tests prove that the multi-layer microspheres can effectively recover the body weight of diarrhea animals, repair pathological injuries of jejunum and colon, and reduce intestinal inflammatory response from the molecular level by inhibiting activation of inflammatory pathways of NF-kappa B and MAPK, down-regulating expression of proinflammatory factors IL-1beta, IL-6 and TNF-alpha and up-regulating the level of an anti-inflammatory factor IL-10. The multilayer microsphere provided by the invention can be used as a novel green safe preparation, and is suitable for preventing and controlling bacterial diarrhea in livestock and poultry breeding.
Resumen de: CN122303457A
The invention discloses a double-channel quadruple ddPCR detection method and kit for simultaneously detecting diarrhea bacteria in sewage based on a proportional fluorescent probe strategy. Compared with the traditional quadruple detection method with four different fluorescence channels, the quadruple ddPCR detection method disclosed by the invention realizes quadruple detection only through the concentration difference of the probes in the two fluorescence channels. Sewage is used as a key interface between excrement and the environment, is an important place for pathogen storage and transmission, and is also a sentry for early warning. According to the double-channel quadruple ddPCR method established by the invention, salmonella spp. SM, shigella spp. SH, vibrio parahaemolyticus VP and vibrio cholerae VC in the sewage can be simultaneously detected, a sewage monitoring technical method is perfected, potential epidemic situation risks can be captured before disease outbreak, and public health prevention and control measures can be taken in time.
Resumen de: CN122297462A
The invention discloses application of decursinol angelica ester in preparation of a medicine for treating and/or preventing infection caused by intracellular bacteria, and relates to the technical field of biological medicine. Wherein the application comprises the step of applying an effective amount of decursinol angelica ester to inhibit the survival of the intracellular bacteria in host macrophages. By adjusting the immune function of host macrophages, for example, enhancing the bactericidal activity of the macrophages or changing the intracellular microenvironment of the macrophages, the decursinol angelica ester specifically inhibits the survival and reproduction of intracellular bacteria (such as mycobacterium tuberculosis, mycobacterium abscessus and salmonella) in cells; a new drug candidate and strategy are provided for treating intractable intracellular bacterial infection, and the beneficial effects of enhancing host-oriented antibacterial immunity and reducing toxic and side effects and potential drug resistance are also achieved.
Resumen de: CN122296300A
The invention belongs to the field of microorganisms, and particularly relates to application of an alternaria phenol compound, and the alternaria phenol compound inhibits pathogenic bacteria salmonella, mycobacterium smegmatis, enterococcus faecalis and staphylococcus aureus, inhibits growth of human lung cancer cells and human breast cancer cells, and has bactericidal and anticancer activity. The method is suitable for developing products in the fields of daily home furnishing, medical care, breeding and the like, and has wide industrial application prospects.
Resumen de: KR20260099243A
본 발명은 간접 ELISA에 보조 진단법으로 활용되거나 양돈장에서 돼지 부종병에 대한 감염 여부를 확인하기 위한 적정한 진단법으로 활용될 수 있는 Stx2e에 대한 단클론 항체 및 다중클론 항체를 활용한 sandwich ELISA에 의한 혈중 및 분변 내 Stx2e 항원량 측정 방법에 관한 것이다.
Nº publicación: CN122278469A 26/06/2026
Solicitante:
山东师范大学
Resumen de: CN122278469A
本发明公开一种无金属毒害的高敏快速荧光探针、制备方法及其在食品致病菌检测中的应用，属于食品检测技术领域。该探针由有机荧光分子石墨烯复合主体、有机无机杂化掺杂剂及特异性识别分子构成；掺杂剂为羧基化纤维素与二氧化硅纳米颗粒，其与复合主体质量比为1:6~10；特异性识别分子采用致病菌适配体，经喷雾涂覆接枝于探针表面。该探针依靠适配体与目标致病菌的特异性结合触发荧光响应，可在5 min内完成检测，灵敏度≥90%，特异性≥98%；探针不含金属成分，无毒害与环境风险，适用于食品现场快速检测及畜禽活体检测；同时制备成本降低90%，单样本检测成本降低40%，具备良好应用前景。
BOPI
Sede Electrónica
