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84
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Última actualización
09/10/2025 [13:07:00]
Resultados 50 a 75 de 84
Resumen de: CN120384115A
The invention discloses a method for rapidly testing sensitivity of salmonella to ceftriaxone. The method comprises the following steps: S1, preparing a salmonella solution; s2, centrifuging the bacterial liquid and removing supernate of the centrifuged bacterial liquid; s3, providing a ceftriaxone solution, wherein the ceftriaxone solution contains ceftriaxone and water; s4, mixing the ceftriaxone solution with the bacterial solution to form a mixed solution, placing the mixed solution in an incubator, and standing for a first preset time; s5, centrifuging the mixed solution after standing for a first preset time, and extracting supernate of the mixed solution; and S6, identifying the ceftriaxone in the supernatant of the mixed solution by using a time-flight mass spectrometer, and judging the sensitivity of the salmonella to the ceftriaxone according to whether a characteristic peak corresponding to the ceftriaxone disappears or not. Compared with PCR (polymerase chain reaction) and LAMP (loop-mediated isothermal amplification) methods, the method has the advantages that the detection result is more reliable, the time consumed by the method is less than that consumed by manual drug sensitivity and full-automatic drug sensitivity identification instruments, and the method can be used for conventional detection in laboratories to timely feed back drug sensitivity results to clinics.
Resumen de: CN120381470A
The invention belongs to the technical field of microbial sterilization preparations, and particularly discloses a broad-spectrum salmonella bacteriophage SD40-16 and application of the broad-spectrum salmonella bacteriophage SD40-16. The bacteriophage SD40-16 can be used for cracking six serotypes of salmonella and escherichia coli including salmonella enteritidis and salmonella typhimurium, is wide in host range and strong in killing capability, and can be used for inhibiting the growth of bacteria. And meanwhile, the strain has good thermal stability and acid-base tolerance, and is easy to proliferate and enrich. The bacteriophage can enhance the antibacterial ability of kanamycin, provides a new drug combination strategy, has an obvious synergistic effect on salmonella resistance when being combined with kanamycin, and has a good application prospect in the aspect of preventing and treating salmonella infection.
Resumen de: CN120361208A
The invention discloses a compound preparation for preventing and treating bacterial diseases of livestock and poultry and a preparation method of the compound preparation. The compound preparation is prepared from the following components in parts by weight: 3.2 to 5.8 parts of astragalus polysaccharide powder, 2.9 to 5.3 parts of xylooligosaccharide powder, 2.5 to 4.8 parts of compound enzyme agent, 2 to 4.4 parts of compound bacterium agent, 1.5 to 3.6 parts of selenium yeast powder, 1.3 to 3.2 parts of egg yolk antibody, 1 to 2.1 parts of hydroxypropyl methyl cellulose, 0.35 to 0.8 part of chitosan and 0.3 to 0.65 part of montmorillonite. The compound preparation disclosed by the invention can effectively inhibit growth and reproduction of viruses such as riemerella anatipestifer, escherichia coli and salmonella, and is beneficial to regulation of immune functions of animals and improvement of body resistance of the animals.
Resumen de: CN119630803A
The present invention relates to an extracellular vesicle containing an antigen protein or a gene encoding the protein, and a use thereof, and more specifically, to an extracellular vesicle containing an antigen protein derived from a virus, a microorganism or a cancer cell or a gene encoding the protein, or a vaccine composition for preventing or treating viral infections, microbial infections or cancers comprising the same. The extracellular vesicle or the vaccine composition comprising the same according to the present invention is a platform applicable to various diseases, has excellent antigen-specific immune response induction effect and stability, and is expected to be effectively used in the field of vaccine development. The vaccines are useful for the prevention or treatment of various diseases including viral infections, microbial infections or cancers.
Resumen de: CN120361018A
The invention discloses a pharmaceutical composition or a vaccine for treating and/or inhibiting salmonella infection, and an application of a small molecule compound Epetrabole hydrochloride. The invention further discloses an application of the pharmaceutical composition or the vaccine and the small molecule compound Epetrabole hydrochloride for treating and/or inhibiting salmonella infection. The MIC value of the small molecule compound is 0.48 mu M, and compared with existing antibiotics for clinically treating salmonella enteritidis infection, the small molecule compound has relatively strong antibacterial activity when the small molecule compound is in a trace amount. An in-vitro killing bacteriostatic activity experiment result shows that the small molecule compound has a certain effect on reduction of the number of bacteria. The Salmonella enteritidis strain has obvious antibacterial activity on a J774A.1 cell model, and can inhibit the expression of a salmonella enteritidis virulence factor T3SS1 in a targeted manner. According to the present invention, the small molecule compound Epetrabole hydrochloride provides a certain inhibition effect on salmonella isolates from different sources, and has a wide application value;
Resumen de: CN120366177A
本发明提供一种四基因敲除减毒鼠伤寒沙门氏菌及其构建方法和应用，所提供的一种四基因敲除减毒鼠伤寒沙门氏菌，是敲除了鼠伤寒沙门氏菌的relA、Asd、manA和sifA基因。本发明构建了四种毒力因子缺失的鼠伤寒沙门氏菌的减毒菌株ΔrelA‑ΔAsd‑ΔmanA‑ΔsifA SM14028，可在体外稳定传代。并经安全性评价试验检测，该菌株毒力无毒力，安全性极高。为了进一步评价ΔrelA‑ΔAsd‑ΔmanA‑ΔsifA SM14028是否能够抵抗亲本株的攻击，进行了免疫效力评价，结果显示，ΔrelA‑ΔAsd‑ΔmanA‑ΔsifA SM14028能够提供有效的免疫保护。因此，本发明的ΔrelA‑ΔAsd‑ΔmanA‑ΔsifA SM14028可作为一种有效的活疫苗或者活载体疫苗，为动物疫病的防控奠定基础。
Resumen de: WO2025152055A1
Provided is a method for testing the in-vitro bactericidal function of a typhoid vaccine immune serum, comprising: testing the in-vitro bactericidal function of a typhoid vaccine immune serum against Salmonella typhi bacteria by means of an opsonophagocytic killing assay, wherein when the phagocytic killing step of the opsonophagocytic killing assay is completed, the Salmonella typhi bacteria having undergone the phagocytic killing step are cultured at the pH of 7.5-9.5. The opsonophagocytic killing assay is applied to Gram-negative Salmonella Typhi bacteria for the first time, and the in-vitro bactericidal levels of typhoid vaccine immune serums are effectively and accurately evaluated.
Resumen de: CN120350143A
The invention discloses a method for rapidly detecting salmonella pullorum by fluorescent quantitative PCR (polymerase chain reaction) and used primers, and the method for rapidly detecting salmonella pullorum by fluorescent quantitative PCR specifically comprises the following steps: (1) collecting a sample; (2) nucleic acid extraction; (3) preparing a reaction system; (4) running a sample detection program; and (5) detecting a test result and judging. According to the rapid detection method disclosed by the invention, an ultra-short-range PCR program is designed as follows: pre-denaturation is performed at 95 DEG C for 2 minutes; according to the present invention, with the program setting, the salmonella pullorum detection time is shortened by about 60% compared with the salmonella pullorum detection time of the commercially available kit and the commercial standard program, and the detection efficiency is substantially improved; the cost of a single detection reagent is reduced by 40% compared with that of an imported kit, and the economic cost is reduced; compared with a traditional culture method, the method has the advantages that the time is 3-5 days earlier, the detection result is reliable, the repeatability is good, and the method can be used for clinical diagnosis and monitoring of SP.
Resumen de: CN120349878A
The poultry salmonella drug resistance detection equipment comprises a bottom plate, the upper end of the bottom plate is fixedly connected with a first vertical plate and a second vertical plate which are arranged left and right, the upper end of the bottom plate is provided with a positioning frame located between the first vertical plate and the second vertical plate, and the upper end of the positioning frame is provided with a storage mechanism; a discharging opening located in the inner side of the positioning frame is formed in the bottom plate in a penetrating mode, a bearing mechanism is arranged on the inner side of the discharging opening, a positioning ring located on the left side of the positioning frame is arranged at the upper end of the bottom plate, a guide rod is fixedly connected between the first vertical plate and the second vertical plate, and the guide rod is sleeved with a sliding sleeve in a sliding mode. According to the device, continuous operation of taking and moving the drug sensitive paper and pasting the drug sensitive paper into the culture dish can be completed, mechanical linkage is utilized, reliability is good, independent driving is not needed, cost is reduced, the situation that the drug sensitive paper is manually taken out of the containing plates in sequence and then taken for pasting operation is not needed, the experiment efficiency is improved, and meanwhile the pollution risk is reduced.
Resumen de: CN120349938A
The invention discloses a broad-spectrum antibacterial lactobacillus plantarum, and belongs to the technical field of microorganisms. The lactobacillus plantarum 9-6 is separated from animal feed, the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.32568, the lactobacillus plantarum 9-6 and fermentation liquor thereof have an obvious inhibition effect on common vibrio parahaemolyticus, vibrio alginolyticus, vibrio harveyi and vibrio vulnificus, and the lactobacillus plantarum 9-6 and the fermentation liquor thereof have the advantages that the lactobacillus plantarum 9-6 and the fermentation liquor thereof have the obvious inhibition effect; and in addition, the antibacterial agent has a relatively good antibacterial effect on common staphylococcus aureus, escherichia coli, listeria monocytogenes, salmonella enterica and bacillus cereus. The lactobacillus plantarum 9-6 has probiotic safety, can grow under an initial pH condition of 4-10 and a high-salt environment, and plays a role in bacteriostasis under an acidic condition. The invention lays a foundation for developing a good antibacterial probiotic preparation and application of a fermentation culture thereof.
Resumen de: CN120330357A
The invention provides a primer probe combination, a kit and a method for detecting salmonella pullorum, and belongs to the technical field of rapid detection of pathogenic microorganisms. A series of primer probes are designed aiming at the ipaJ gene of the salmonella pullorum strain, a primer probe combination with the best amplification effect is screened from the primer probes, and the salmonella pullorum is detected by utilizing the primer probe combination and adopting a fluorescent RAA method. The detection efficiency, sensitivity (the lowest detection limit is 1.5 * 10 <-1 > pg/mu L) and accuracy of the detection method are higher than those of common PCR, and rapid specific detection of salmonella pullorum can be achieved.
Resumen de: CN120324365A
The invention belongs to the field of biotechnology and medical preparations, and provides a yeast microcapsule delivery BBR/EGCG probiotic preparation and application thereof. The probiotic Nissle1917 and the anti-inflammatory and anti-oxidation natural products BBR and EGCG are packaged by adopting the yeast membrane, so that the probiotic Nissle1917 has good tolerance and cell targeting property, is easy to colonize in intestinal tracts and exert anti-inflammatory and mucous membrane repairing functions, particularly has a better treatment effect on enteritis caused by salmonella typhimurium, and has a wide application prospect. The problem that an existing probiotic agent is poor in bacterial enteritis treatment effect is solved.
Resumen de: CN120330263A
The invention belongs to the technical field of biology, and particularly relates to a construction method of a TXNIP gene overexpressed macrophage cell strain and application of the TXNIP gene overexpressed macrophage cell strain in salmonella typhimurium infection.The TXNIP gene overexpressed RAW264.7 macrophage cell strain (oeTXNIP-RAW264.7) is successfully constructed by utilizing CAGG-TXNIP recombinant plasmids and combining with a lentivirus expression system, and the TXNIP gene overexpressed RAW264.7 macrophage cell strain (oeTXNIP-RAW264.7) can be used for treating salmonella typhimurium infection. The gene overexpression effect is verified through an RT-qPCR (Reverse Transcription-Quantitative Polymerase Chain Reaction) method and a Western blot method. A design test proves that after the over-expression TXNIP vector is constructed and transferred into RAW264.7, compared with a control group (a CAGG empty vector is transferred into RAW264.7), infection of salmonella can be remarkably resisted. The invention has the characteristics of strong innovation, good safety and the like, provides a reliable technical platform for antibacterial target screening and innovative drug research, and has important application value in the field of biomedicine.
Resumen de: CN120324371A
The invention relates to a radioiodine-labeled drug-loaded bacterial outer membrane vesicle as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method comprises the following steps: expressing casein-rich attenuated salmonella typhimurium VNP20009 to secrete bacterial outer membrane vesicles, loading an anti-tumor drug by using an ultrasonic method, and combining with an oxidant-mediated radioiodine labeling technology to construct radioiodine-labeled drug-loaded bacterial outer membrane vesicles with tumor targeting property, so as to prepare the drug-loaded bacterial outer membrane vesicles. The performance is optimized through polyethylene glycol modification, the drug loading mass ratio is controllable, the radiolabeling rate is high, the in-vitro stability is good, and the in-vivo safety is good. The drug-loaded bacterial outer membrane vesicle can simultaneously realize SPECT/PET imaging and targeted therapy, is suitable for solid tumors such as brain glioma, colon cancer and the like, has the functions of drug delivery, immune activation and radiodiagnosis, has a good application prospect, and provides a new tool for diagnosis and treatment of tumors.
Resumen de: CN120330356A
The invention provides a primer probe combination, a kit and a method for detecting salmonella enteritidis, and belongs to the technical field of rapid detection of pathogenic microorganisms. A series of primer probes are designed aiming at the Prot6e gene of the salmonella enteritidis, a primer probe combination with the best amplification effect is screened from the primer probes, and the salmonella enteritidis is detected by utilizing the primer probe combination and adopting a fluorescent RAA method. The detection efficiency, sensitivity (the lowest detection limit is 1.5 * 10 <-1 > pg/mu L) and accuracy of the detection method are all higher than those of common PCR, and rapid specific detection of salmonella enteritidis can be achieved.
Resumen de: CN120330108A
The invention relates to the technical field of microorganisms, in particular to bacillus altitudinis MLF-1 and a complex microbial inoculant and application thereof.The bacillus altitudinis strain MLF-1 is obtained by being separated from healthy cattle rectum contents by a research group, and it is detected that the strain has the good beta-1, 4-glucanase producing capacity, and the beta-1, 4-glucanase producing capacity is high; the antibacterial effect is achieved on enterobacter aerogenes, staphylococcus aureus, salmonella typhimurium and escherichia coli; the bacillus altitudinis MLF-1 has good fermentation capacity on the siraitia grosvenorii residues, after the bacillus altitudinis MLF-1 is mixed with the bacillus licheniformis strain JSF-9 and the bacillus safensis strain MLL-5 to prepare the complex microbial inoculant, the nutritional value and the disease resistance of the siraitia grosvenorii residues fermented by the complex microbial inoculant are remarkably improved, 10%-15% of the complex microbial inoculant is added into a basic ration, and the content of the complex microbial inoculant in the siraitia grosvenorii residues fermented by the complex microbial inoculant is reduced. The Jersey cattle feed has the effects of reducing cost and improving efficiency for feeding Jersey cattle.
Resumen de: WO2025151522A2
A broadly protective Shigella-ETEC vaccine includes components to cover multiple Shigella species and serotypes as well as multiple different colonization factors of ETEC. ETEC colonization factors CS2 and CS3 are among the most prevalent CFs found on ETEC isolates associated with diarrhea. These two factors are important components of a vaccine that can confer broad protection against ETEC. High level expression of these heterologous antigens in Shigella live vectors results in stronger immune responses. This specification describes the genetic engineering of DNA sequences encoding upstream sequences, including promoter and ribosome binding sites, that results in increased expression of CS2 and CS3 in Shigella live vectors and that leads to stronger immune responses when used as a vaccine in animal models.
Resumen de: AU2023338191A1
The present invention provides compositions and methods for inducing an immune response in a subject in need thereof, comprising administering to the subject an immunologically-effective amount of a live
Resumen de: WO2024050627A1
Purified antigens are usually weakly immunogenic and require the addition of immunostimulatory agents and/or delivery systems to generate robust antigen-specific responses. The present application relates to self-assembling polypeptides that may be conjugated to immunogens and have the ability to self-assemble into immunogen-displaying nanofilaments that activate the humoral and cellular immune responses. The self-assembling polypeptide comprises an amino acid sequence having at least 60% identity with the sequence of the R4 and R5 domains from a Curli-specific gene A (CsgA) protein. The present application also relates to nucleic acids encoding the self-assembling polypeptide/immunogen conjugates, to compositions and vaccines comprising the self-assembling polypeptide/immunogen conjugates or nucleic acids, as well as to methods for inducing an immune response against an immunogen and/or for preventing and/or treating a microbial infection, cancer or any pathological conditions in which vaccination may be useful such as autoimmune diseases and allergies, in a subject.
Resumen de: CN120314573A
The invention provides a polysaccharide antigen derived from salmonella pullorum and marked by fluorescent molecules as well as a preparation method and application of the polysaccharide antigen. The invention provides a simple, convenient and rapid extraction method of the salmonella pullorum polysaccharide antigen, and the polysaccharide antigen for bacterial serological detection is prepared by combining fluorescence labeling on the basis of the experimental principle of fluorescence polarization. The polysaccharide antigen prepared according to the method provided by the invention can be used for serological detection of salmonella pullorum and has good sensitivity, and a new method is provided for detection of salmonella pullorum infection.
Resumen de: CN120305383A
The invention belongs to the technical field of medicines, and particularly relates to application of 10-undecylenic acid and polymyxin in preparation of an antibacterial drug, and the antibacterial drug aims at one or more of escherichia coli, salmonella and klebsiella pneumoniae. The antibacterial agent aims at bacteria which are resistant to polymyxin. The bacteria directed by the antibacterial agent are multi-drug-resistant gram-negative bacteria. Through a chessboard method minimum inhibitory concentration test, an in-vitro bacterial growth curve proves that 10-undecylenic acid synergistically enhances the antibacterial activity of polymyxin, and meanwhile, a mouse drug-resistant bacterial infection model test proves that 10-undecylenic acid can effectively enhance the in-vivo effectiveness of polymyxin at the animal level. The invention provides a new application of 10-undecylenic acid in enhancing the antibacterial activity of polymyxin antibiotics, and can solve the technical problems of low clinical drug resistance and therapeutic index of polymyxin and the like.
Resumen de: CN120309697A
The invention discloses a polypeptide drug for resisting gram-negative bacteria and application, and belongs to the technical field of biological medicine. The MIC of the antibacterial peptide obtained through screening on escherichia coli, salmonella typhimurium, pseudomonas aeruginosa, klebsiella pneumoniae, shigella sonnei and stenotrophomonas maltophilia is 16 mu g/mL, 2 mu g/mL, 16 mu g/mL, 4 mu g/mL, 2 mu g/mL and 4 mu g/mL respectively, and the antibacterial peptide has broad-spectrum antibacterial performance. The hemolytic activity and toxicity of the compound are lower than therapeutic concentration threshold values, and the compound can be used for preparing drugs or medical products for treating multi-drug-resistant bacterium infection.
Resumen de: CN120290742A
The invention discloses an identification marker and an identification method for germplasm of Salmonella salmon, and relates to an identification method for Salmonella salmon. According to the method, the problem of shortage of a Salmon salmon germplasm identification technology is solved. The method comprises the following steps: 1, extracting genome DNA of a to-be-identified sample; 2, carrying out PCR (Polymerase Chain Reaction) amplification by using a species specific primer; 3, agarose gel electrophoresis, recovery and purification; and 4, sequencing the purified PCR product, comparing the sequencing result with an identification sequence, splicing a homologous sequence, and comparing the difference of five basic groups positioned at the 15th bp, the 23rd bp, the 29th bp, the 39th bp and the 84th bp. The molecular marker is used for identifying the salmon arsalmonella, the salmon americana, the oncorhynchus masou and the oncorhynchus mykiss, has the characteristics of high efficiency, rapidness, stable result and high accuracy, and has important application value in the aspect of germplasm identification of the salmon arsalmonella.
Resumen de: CN120284881A
The invention discloses preparation and application of micromolecular coated oncolytic bacteria, and relates to the field of nano-drugs. According to the coated bacteria, the surface of attenuated salmonella VNP20009 is coated with a nano-coating formed by coordination of micantrone and calcium ions, a bacterial antigen signal is shielded, so that the peripheral clearance rate and toxicity risk of the attenuated salmonella VNP20009 in blood circulation are reduced, and the coated bacteria have good biocompatibility and can maintain natural physiological characteristics and biodegradability of the bacteria. In order to solve the problems of lack of effective molecular targets and high immunosuppression of triple negative breast cancer (TNBC), the coated oncolytic bacteria utilize the natural tropism of VNP20009 on TNBC and the physiological targeting motion characteristic to directionally deliver miltroquinone and calcium ions, and cooperate with the oncolytic bacteria to kill tumor cells; bacterial surface antigen signals are shielded, so that tumor accumulation is increased, peripheral toxicity is avoided, and a breakthrough is provided for overcoming long-term failure of oncolytic bacteria clinical tests.
Nº publicación: CN120290423A 11/07/2025
Solicitante:
GUANGXI AGRICULTURAL VOCATIONAL AND TECHNICAL UNIV
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Resumen de: CN120290423A
The invention relates to the technical field of microorganisms, in particular to bacillus licheniformis JSF-9 and a complex microbial inoculant and application thereof.The strain JSF-9 is obtained by being separated from healthy cattle rectum contents by a research group, and it is detected that the strain has the good beta-1, 4-glucanase producing capacity, and the beta-1, 4-glucanase producing capacity is high. The antibacterial effect on staphylococcus aureus, salmonella typhimurium and shigella flexneri is achieved; the strain has a good bagasse fermentation capability, for example, after the strain, bacillus altitudinis MLF-1 and bacillus safensis MLL-5 are prepared into a mixed microbial inoculum, the bagasse fermentation capability is better, and verification shows that the complex microbial inoculum can effectively inhibit the reproduction of harmful bacteria, so that the preservation period of fermented feed is prolonged, and the yield of the fermented feed is improved. Animal feeding experiments find that the nutritional value and the disease resistance of the complex microbial inoculant fermented bagasse are remarkably improved, 10-15% of the complex microbial inoculant fermented bagasse is added into basic ration, and the cost-reducing and effect-increasing effects are achieved for feeding Jersey cattle.
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