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117
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Última actualización
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Resultados 50 a 75 de 117
Resumen de: CN122278660A
The invention discloses a microbial agent for fermenting low-nitrite and low-sodium pickled Chinese cabbages and a method for preparing the pickled Chinese cabbages, the microbial agent comprises leuconostoc mesenteroides LM701 and lactobacillus plantarum LP705, the microbial agent has good nitrite degradation capacity, growth of harmful bacteria such as escherichia coli, staphylococcus aureus and salmonella in fermentation of the pickled Chinese cabbages can be effectively inhibited, low-sodium chloride salt fermentation can be achieved, and the low-nitrite and low-sodium pickled Chinese cabbages can be obtained. The nitrite content of the prepared pickled Chinese cabbage is less than or equal to 4 mg/kg, and the pickled Chinese cabbage tastes crisp. The nitrite degradation rate of the fermented pickled Chinese cabbages reaches 63.8% or above. And the nitrite content of a 1% edible salt concentration group is 2.69 mg/kg.
Resumen de: CN122271341A
The invention discloses a preparation method and application of a compound bio-enzyme quaternary ammonium salt preparation for pet disinfection. The preparation is prepared from compound quaternary ammonium salt, peony flower bud extract, lysozyme, lysostaphin, lactic acid, sodium hyaluronate and water. The compound quaternary ammonium salt is scientifically compounded with various biological enzymes (lysozyme and lysostaphin), plant extracts (peony bud extracts) and organic acid (lactic acid), the synergistic interaction effect of all the components is fully exerted, and the defects that a single component is narrow in bacteriocidal spectrum, prone to generating drug resistance, large in skin irritation and the like are overcome. The preparation has a rapid and efficient killing effect on various microorganisms such as salmonella typhimurium, escherichia coli, staphylococcus aureus, candida albicans, trichophyton mentagrophytes and poliovirus.
Resumen de: CN122272777A
The invention belongs to the technical field of molecular biology, and particularly discloses application of a phospholipase PLA2G7 gene in preparation of a preparation for improving salmonella resistance of poultry macrophages, poultry is chicken, the CDS sequence of the phospholipase PLA2G7 gene is shown as SEQ ID NO: 1, and the CDS sequence of the phospholipase PLA2G7 gene is shown as SEQ ID NO: 2. The expression level or activity of the phospholipase PLA2G7 gene in the chicken macrophages is improved to promote the expression of proinflammatory factors of the chicken macrophages and enhance the phagocytosis and sterilization capability of the chicken macrophages on salmonella. Compared with the prior art, the invention proves that the improvement of the expression level or activity of the phospholipase PLA2G7 gene in the chicken macrophage can promote the expression of a proinflammatory factor of the chicken macrophage and enhance the phagocytosis and sterilization capability of the chicken macrophage on salmonella.
Resumen de: CN122278715A
The invention discloses bdellovibrio and application thereof in cracking salmonella enteritidis, and belongs to the technical field of microorganisms. The preservation number of the strain is CCTCC (China Center For Type Culture Collection) NO: M 20232311, and the HCB006 is a new Bdellovibrio species through multi-phase classification and identification such as 16S rRNA (Ribosomal Ribonucleic Acid) gene, average nucleotide similarity, digital DNA-DNA hybridization and food catching recipe. The invention also discloses a biological control preparation containing the bdellovibrio bacteriovorus and application of the biological control preparation in cracking of salmonella enteritidis. The bdellovibrio HCB006 provided by the invention is high in splitting decomposition efficiency and strong in environmental adaptability, can be used as an antibiotic alternative scheme, is used for biological prevention and control of salmonella in food processing, culture environment and medical related fields, and has important significance on prevention of prevalence of dangerous pathogenic bacteria, improvement of food health and the like.
Resumen de: WO2025037284A2
A vaccine and methods of treatment thereof, wherein the vaccine comprises a recombinant Gram-negative bacteria genetically modified to express a first antigen fusion peptide comprising a neoantigen or series thereof, said neoantigen or series thereof associated with a first secretion signal from a double membrane-spanning secretion system and a second antigen fusion peptide comprising a homologous neoantigen or series thereof, associated with a second secretion signal from an outer membrane-spanning secretion system. The Gram-negative bacteria may be further modified for quadmodal transport. Specifically, the fusion peptides include signal peptides are each associated with a Type III (T3SS) and a Type V (T5SS) secretion system.
Resumen de: CN122256177A
The invention relates to the technical field of microorganisms, in particular to bacillus subtilis BS-1 and application of the bacillus subtilis BS-1 in buffalo silage, the strain BS-1 has good bacteriostatic activity on escherichia coli, salmonella and streptococcus uberis, and after the strain BS-1 is mixed with orange peel and manioc waste according to a specific proportion to be fermented, the bacillus subtilis BS-1 can be prepared into the buffalo silage. The antibacterial spectrum of the obtained silage is remarkably enhanced, and escherichia coli, campylobacter jejuni and salmonella causing diarrhea as well as streptococcus uberis, staphylococcus aureus and streptococcus agalactiae causing mastitis can be inhibited at the same time. In the feed, after 60%-75% of orange peel and 25%-40% of manioc waste are mixed, the crude protein content of a fermentation product is remarkably increased, and the fiber content is reduced. Feeding tests show that the feed can significantly improve the lactation yield and milk quality of the milk buffalo in the lactation period and effectively relieve diarrhea. The invention provides the silage which is safe and efficient and has nutrition and disease prevention functions.
Resumen de: CN122256270A
The invention discloses a broad-spectrum bacteriophage targeting mucous escherichia coli, cronobacter and salmonella and application of the broad-spectrum bacteriophage. The invention provides a bacteriophage Escherichia coli phagevB EcoP 3BB7B capable of efficiently cracking mucus type enterobacter, the bacteriophage can specifically crack escherichia coli which can produce corac acid and is in a mucus type phenotype, and the technical bottleneck that adsorption of a mucus layer to most bacteriophages is limited is broken through; compared with the prior art, the recombinant plasmid has the advantages that the recombinant plasmid has high specific activity and cross-genus splitting capacity, not only has good splitting activity on mucus type escherichia coli, but also can effectively split important food-borne pathogenic bacteria such as various serotypes of salmonella, cronobacter sakazakii and the like, and the range of a host spectrum is remarkably widened. The bacteriophage can achieve efficient amplification under the condition of low infection complex number, is good in environmental stability, high in lysis activity, free of drug-resistant genes and toxicity-related genes and high in safety, and has good clinical and food safety prevention and control application prospects.
Resumen de: CN122256201A
The invention relates to bacteroides fragilis and application thereof, the bacteroides fragilis is preserved in the China General Microbiological Culture Collection Center (CGMCC) on April 14, 2026, and the preservation number is CGMCC No. 38257. The strain can regulate and control STING-dependent training immunity, effectively resist infection of salmonella typhimurium and H9N2 avian influenza virus, maintain the integrity of a host intestinal barrier and relieve inflammatory injury. The bacteroides fragilis provided by the invention has good biological safety, can be used as a training immunity inducer, is expected to be used as a candidate probiotic or vaccine adjuvant for preventing/treating bacterial and virus infection, is suitable for human health and poultry breeding industry, and provides a new solution for resisting antibiotic resistance.
Resumen de: CN122235342A
The invention relates to the technical field of biological detection, and particularly discloses a gene chip for simultaneously detecting 12 food-borne pathogenic bacteria and application thereof, the gene chip comprises a polyvinyl chloride solid-phase carrier, and a specific probe, a positive control probe and a hybridization control probe which are fixed on the surface of the polyvinyl chloride solid-phase carrier. The gene chip can be used for simultaneously detecting salmonella, escherichia coli O157: H7, staphylococcus aureus, listeria monocytogenes, bacillus cereus, vibrio parahaemolyticus, vibrio cholerae, vibrio fluvialis, shigella flexneri, campylobacter jejuni, clostridium perfringens and yersinia enterocolitica. The gene chip disclosed by the invention is arranged by adopting a preset dot matrix, and detection is realized through sample total DNA extraction, multiple PCR amplification and biotin labeling, chip hybridization, washing, sealing, enzyme labeling, color development and scanning interpretation; the method can realize synchronous detection of 12 target bacteria, and has good specificity, repeatability and application value.
Resumen de: WO2024025312A1
The present invention relates to a recombinant expression vector for secretion of IFN-β proteins and an attenuated Salmonella strain transformed by means of same, and provides: a recombinant expression vector comprising flgM genes, IFN-β genes, and flhDC genes; an attenuated Salmonella strain transformed by means of same; and a pharmaceutical composition for cancer treatment comprising the attenuated Salmonella strain as an active ingredient.
Resumen de: EP4279503A1
0001 Provided is a method that enables the presence and/or amount of bacteria of Enterobacteriaceae in a food/drink sample, an environmental sample, or a biological sample to be detected easily and efficiently in a short amount of time. Said method includes a step for simultaneously detecting, on the basis of an antigen-antibody reaction, the presence and/or amount of bacteria of Enterobacteriaceae of at least two different genera in a sample.
Resumen de: CN122214285A
The invention discloses application of a salmonella bacteriophage vBSalDSP13 and a rapid detection method of the salmonella bacteriophage vBSalDSP13. The preservation number of the bacteriophage vBSalDSP13 is GDMCC No: 67876-B1, and the preservation number of the bacteriophage vBSalDSP13 The virulent bacteriophage vBSalDSP13 provided by the invention is wide in host spectrum, can split up to 25 salmonella serotypes, can split two strains of escherichia coli at the same time, and has a characteristic molecular target. The bacteriophage SP13 has good thermal stability, pH stability and chloroform tolerance, is not easy to inactivate in the application process, and has a good inhibition effect on target bacteria in milk and chicken. In conclusion, the bacteriophage SP13 can be used as a single inhibitor or combined with other pathogenic bacteria bacteriophages to form an inhibitor for preventing and controlling pathogenic bacteria such as salmonella and the like.
Resumen de: CN122214226A
本发明公开了一种htrA基因敲除的减毒沙门氏菌重组工程菌株及其应用，对减毒沙门氏菌VNP20009进行基因组遗传改造，将基因组中的htrA基因敲除，获得ΔhtrA‑VNP菌株。通过回补性表达带有/不带有信号肽的HtrA蛋白，首次证实信号肽对于HtrA蛋白的功能发挥至关重要。无信号肽的htrA基因回补菌株与ΔhtrA‑VNP菌株生物学表型无显著差异。本发明所述的表达带有信号肽的HtrA蛋白的ΔhtrA‑VNP菌株，HtrA蛋白通过调控细菌胞外多糖水平，一方面影响菌株的免疫原性与抗癌效果，另一方面影响菌株对抗巨噬细胞的杀伤效果，进而影响细菌在体内的分布特性。本发明基于htrA基因活性作用模式，建立了瘤内时空特异性启动表达带有信号肽的HtrA蛋白的ΔhtrA‑VNP菌株，实现更高效、安全与精准的活体微生物抗肿瘤治疗。
Resumen de: CN122214382A
The invention discloses an application of serine and glycine depletion engineering bacteria targeting soft tissue sarcoma, which comprises the steps of construction and identification of engineering bacteria SGS1, in-vitro experimental verification, material screening and preparation, and construction and identification, during use, screening and preparation of vector bacteria: selecting attenuated salmonella typhimurium VNP20009 as the vector bacteria, and screening and preparing the vector bacteria by using the attenuated salmonella typhimurium VNP20009 as the vector bacteria; the strain has high tumor enrichment, is purified by a centrifugal washing method after being subjected to sterile culture amplification, impurities and infectious microbes in a culture medium are removed for later use, a serine dehydratase gene from pseudomonas is selected, a target gene segment is obtained through a PCR amplification technology, and after the correctness of the segment size is verified through agarose gel electrophoresis, the target gene is recovered for later use. A secretory vector and a tumor microenvironment responsive promoter are selected, the secretory vector is subjected to enzyme digestion treatment, so that the vector has a site connected with a target gene, and meanwhile, the tumor microenvironment responsive promoter can specifically promote the expression of the target gene in a tumor microenvironment for later use.
Resumen de: CN122214196A
The invention relates to a strain of WZ-93 for relieving constipation and application thereof, the preservation number of the WZ-93 is CGMCC No.37033, and the WZ-93 has antibacterial activity on Escherichia coli, salmonella enteritidis and staphylococcus aureus, and can be used for treating constipation. The compound can be copolymerized with Escherichia coli, Salmonella enteritidis, Staphylococcus aureus, Streptococcus parablood, Enterobacter cloacae and Isostercas verbena, can grow and propagate by using oligosaccharide or D-psicose as a carbon source, can reduce secretion of inhibitory peptide neurotransmitters, can promote generation of excitatory peptide neurotransmitters, can promote secretion of anti-inflammatory factors, and can be used for preparing anti-inflammatory drugs. The composition can inhibit the secretion of proinflammatory factors, can enhance the intestinal peristalsis function, reduce the first black excrement discharge time, increase the excrement water content, improve the alpha-diversity of intestinal flora, promote the proliferation of beneficial bacteria and reduce the abundance of harmful bacteria, and can be used for preparing preparations or products for relieving constipation and preventing pathogenic bacterium infection.
Resumen de: CN122212224A
The invention discloses preparation of feed-grade high-specific-surface-area nano zinc oxide and application of the feed-grade high-specific-surface-area nano zinc oxide to piglets. Crude zinc oxide is adopted as a raw material, and the zinc oxide is prepared through the processes of ammonia leaching, ammonia distillation, calcination and the like. The feed-grade high-specific-surface-area nano zinc oxide prepared by the method has the specific surface area of more than 60m < 2 >/g, the ZnO content of more than 95%, the particle size of less than 100nm, the average particle size of 50-100nm, the content of harmful element lead of less than 10mg/kg, the arsenic content of less than 3mg/kg and the cadmium content of less than 8mg/kg. Compared with common nano-zinc oxide (OZO), the nano-zinc oxide has better stability in simulated piglet gastrointestinal fluid, has better bacteriostatic activity on escherichia coli K88, staphylococcus aureus and salmonella suis, has smaller toxicity on a pig small intestine epithelial cell line IPEC-J2, can significantly reduce cell apoptosis and generation of active oxygen in cells, and can be used for preparing the antibacterial nano-zinc oxide. 150mg/kg of the feed additive is added into daily ration of the first two weeks after weaning of the piglets to reduce the diarrhea of the weaned piglets, improve the average daily gain of the piglets and reduce the feed-gain ratio, and the feed additive has a good effect.
Resumen de: CN120992924A
The invention belongs to the technical field of Ultrap1 enzyme quantitative detection, and particularly relates to an Ultrap1 enzyme double-antibody sandwich ELISA (enzyme-linked immuno sorbent assay) kit and application. Comprising an elisa plate coated with an anti-Ultrap1 enzyme mouse monoclonal antibody, an anti-Ultrap1 enzyme rabbit polyclonal antibody, an HRP-labeled goat anti-rabbit antibody, a diluent, a cleaning solution, a confining solution, a developing solution and a stop solution. According to the present invention, the complex of the Ulp1 enzyme and the SUMO tag protein is adopted as the immunogen to simultaneously immunize mice and New Zealand rabbits so as to prepare different species of the good affinity Ulp1 enzyme antibodies, and then the optimal reaction condition is further screened to develop the stable double-antibody sandwich ELISA detection kit with characteristics of high specificity and strong sensitivity, the defects in the prior art can be effectively overcome.
Resumen de: CN122182751A
本发明公开了一种细菌复合疫苗与顺铂的协同抗肿瘤组合及其应用，属于肿瘤药物制备技术领域。所述抗肿瘤组合包括以下成份：细菌复合疫苗和顺铂。本发明通过细菌复合疫苗和顺铂的协同配合，在对肿瘤模型的试验小鼠进行治疗时发现，相较于单一的细菌复合疫苗治疗组和单一的顺铂治疗组，二者的协同用药对肿瘤细胞增殖的抑制作用显著上升，具有良好的抗肿瘤效果。
Resumen de: US20260158079A1
Provided herein are compositions comprising substantially non-viable Gram-negative bacterial organisms that have a substantial reduction in endotoxin activity and/or pyrogenicity and methods for treating a cancer using the same. Also provided are methods for treating cancer provided herein, comprising administering to a mammal diagnosed with cancer, substantially non-viable Gram-negative bacteria having a substantial reduction in endotoxin activity and/or pyrogenicity, in an amount sufficient to inhibit growth or metastasis of the cancer. An additional method is provided comprising administering viable or non-viable Gram-negative bacterial organisms that have a genetic defect that results in a substantial loss of lipopolysaccharide within the outer membrane of the bacteria. Further provided are methods for reducing endotoxin activity and/or pyrogenicity in Gram-negative bacteria comprising treatment with polymyxin and glutaraldehyde.
Resumen de: AU2024374864A1
Cyclic dinucleotides, which are a type of signaling substance for cancer treatment, are secondary messengers of intracellular events initiated by GPCR activation and act as a stimulator of interferon genes (STING), and thus can have a significant effect on tumor suppression. Meanwhile, when cancer occurs in a subject, angiogenesis and cell growth proceed at a very high rate in the body, and thus an oxygen-deficient environment is created due to incomplete angiogenesis in cancer tissues, which may be very suitable for the proliferation of anaerobic bacteria such as Salmonella sp. strains or E. coli. Therefore, the present invention relates to a DNA construct into which is introduced a gene for an enzyme that synthesizes a signaling substance for cancer treatment, e.g., a cyclic dinucleotide, or to a strain transformed with a vector comprising the DNA construct. The DNA construct or the strain transformed with a vector comprising the DNA construct, according to the present invention, targets cancer in a subject and then secretes C-di-AMP or C-di-GMP synthase in the surrounding environment of the cancer, and thus can very effectively prevent or treat cancer and, at the same time, can diagnose cancer in real time.
Resumen de: CN122171800A
The invention belongs to the technical field of biological detection, and provides a biosensor for detecting salmonella typhimurium based on CRISPR/Cas12a activated by a DNA nanowire amplified by DNAzyme, and the biosensor comprises CRISPR/Cas12a protein, Mg < 2 + >, an aptamer Apt with a nucleotide sequence as shown in SEQ ID NO: 1-8, a chain A, a chain AB, a DNAzyme chain, a chain H1, a chain H2, a chain H3 and crRNA. The biosensor is high in detection sensitivity, low in detection limit, high in specificity, small in background interference, stable in fluorescence signal, simple to operate, mild in reaction condition, suitable for on-site rapid detection and suitable for actual food sample detection, the detection range can reach 10 <-10 > cfu/mL order of magnitude, the adding standard recovery rate is 100.3%-103.9%, and the detection cost is low. The method can be widely applied to salmonella typhimurium detection in the fields of food industry and public health.
Resumen de: CN122168441A
The invention discloses antibacterial distiller's grains containing bacillus Zhangzhou GBW-NX as well as a preparation method and application thereof, and belongs to the technical field of microorganisms. The preservation number of the Zhangzhou bacillus GBW-NX is CGMCC (China General Microbiological Culture Collection Center) No.27402. Experiments prove that the Zhangzhou bacillus GBW-NX has the antibacterial effect of inhibiting escherichia coli, salmonella and staphylococcus aureus, and the Zhangzhou bacillus GBW-NX is put into a solid culture medium containing distiller's grains for fermentation and enzymolysis to prepare the antibacterial distiller's grains. The invention also proves that the bacteriostatic Baijiu vinasse can improve the intestinal functions of ruminants including lactation cows, increase the milk yield of the cows, broaden the application range of the Bacillus Zhangzhou GBW-NX, provide a new direction for feeding of the ruminants, and have important meanings for breeding of the ruminants, and the bacteriostatic Baijiu vinasse can be used for improving the intestinal functions of the ruminants including the lactation cows, improving the milk yield of the cows and widening the application range of the Bacillus Zhangzhou GBW-NX.
Resumen de: CN122168470A
The invention discloses bacillus subtilis as well as a screening method and application thereof. The bacillus subtilis is named as bacillus subtilis BS61, is preserved in the China General Microbiological Culture Collection Center on September 4, 2025, and has the preservation number of CGMCC (China General Microbiological Culture Collection Center) No.35815. The invention further discloses a preparation method of the bacillus subtilis. The screening method comprises phenotypic screening and genome screening, the phenotypic screening is to test the acid resistance, cholate resistance, high temperature resistance and artificial gastrointestinal fluid resistance of the strain, and reveal the acid resistance, cholate resistance, high temperature resistance and artificial gastrointestinal fluid resistance of the BS61 strain; the antibacterial effect on various pathogenic bacteria such as escherichia coli K88 and salmonella typhimurium is obviously superior to that of a bacillus subtilis standard strain BS168; according to the present invention, the low-abundance drug-resistant gene strain contains the bacteriostatic secondary metabolism gene clusters such as Fengycin, ThurincinH, Bacillus bactin and the like, does not have the aggressive virulence factor, and only contains three low-abundance drug-resistant genes; the compound can be applied to preparation of livestock and poultry feed additives, has no wide drug resistance risk, does not affect animal body health and food safety
Resumen de: KR20260084896A
본 발명은 콜레라균 또는 장티푸스균에 특이적인 단일클론 항체 및 이를 이용한 콜레라와 장티푸스 동시 신속진단키트에 관한 것으로, 보다 상세하게는 서열번호 2, 서열번호 4, 서열번호 6 또는 서열번호 8의 아미노산 서열로 표시되는 중쇄 가변영역을 포함하는 콜레라균(Vibrio cholerae)에 특이적으로 결합하는 단일클론 항체 및 서열번호 10 또는 서열번호 12의 아미노산 서열로 표시되는 중쇄 가변영역을 포함하는 살모넬라 티피(Salmonella typhi)에 특이적으로 결합하는 단일클론 항체를 이용한 콜레라와 장티푸스 동시 신속진단키트에 관한 것이다.
Nº publicación: CN122139700A 05/06/2026
Solicitante:
GUANGXI UNIV
GUANGXI YANKUN BIOLOGICAL TECH CO LTD
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Resumen de: CN122139700A
The invention discloses an induction method for improving activity of hermetia illucens antibacterial peptide, and belongs to the technical field of insect biology. According to the method, Rhodopseudomonas palustris (RP) is added into strengthened basic ration of the fifth-instar larvae of hermetia illucens, and ultrasonic strengthening and short-time heat stress treatment are combined, so that efficient induction of the antibacterial peptide is realized. Test data show that the diameter of a salmonella inhibition zone of the crude extract of the antibacterial peptide induced by the method can reach 40.48 mm. The method solves the problem of large-scale production of antibacterial peptide induction, balances the immune cost caused by high-intensity induction by strengthening a substrate compensation mechanism, has the advantages of strong induction activity, stable growth performance, low process cost and the like, and has an application prospect in the fields of animal feed additives and biological bacteriostatic preparations.
BOPI
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