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116
resultados
Última actualización
02/04/2026 [07:20:00]
Resultados 75 a 100 de 116
Resumen de: CN121378418A
The invention discloses a group of antibacterial polypeptides aiming at gram-negative bacteria, and belongs to the technical field of biological medicines. According to the invention, a group of antibacterial peptides is obtained through screening, and the antibacterial peptides have good broad-spectrum antibacterial performance on escherichia coli, salmonella typhimurium, pseudomonas aeruginosa, klebsiella pneumoniae, shigella sonnei and stenotrophomonas maltophilia. Wherein the hemolytic activity and toxicity of the antibacterial peptides 11A-1, 11A-4 and 11A-5 are lower than therapeutic concentration threshold values, and the antibacterial peptides 11A-1, 11A-4 and 11A-5 can be used for preparing drugs or medical products for treating multi-drug-resistant bacterial infection.
Resumen de: CN121379984A
The invention belongs to the technical field of microorganisms, and discloses a salmonella enteritidis bacteriophage PC571, a bacteriophage composition thereof and application of the bacteriophage PC571, the preservation number of the bacteriophage PC571 is CGMCC No.46168, and the bacteriophage PC571 is preserved in China General Microbiological Culture Collection Center on August 16, 2024. The salmonella enteritidis bacteriophage PC571 is wide in splitting spectrum, has good splitting capability on salmonella bacteriophage resistant bacteria, and can cooperate with other existing salmonella bacteriophages for bacteriostasis. The salmonella enteritidis bacteriophage PC571 or the bacteriophage composition thereof can be used as an active ingredient to prepare a pharmaceutical preparation, an environmental disinfectant, a bacteriostatic agent, a detection kit and the like for application. The salmonellosis in a livestock farm can be purified by mixing the phage with water and feed for a long time, and in addition, the phage is relatively high in safety, can effectively prevent and treat infection of salmonella with phage resistance, and has a market application prospect.
Resumen de: CN121369432A
The invention belongs to the technical field of bacteriostatic agents and application thereof, and particularly relates to a Tibetan medicine composition, a preparation method and application of the Tibetan medicine composition in bacteriostatic products. The traditional Tibetan medicine sophora moorcroftiana seeds, cortex phellodendri, myricaria laxiflora and artemisia sieversiana are compounded, active ingredients in the traditional Tibetan medicine sophora moorcroftiana seeds, cortex phellodendri, myricaria laxiflora and artemisia sieversiana are extracted, the water-soluble plant source bacteriostatic agent with a good bacteriostatic effect is prepared, and the alkaloid content in the obtained bacteriostatic agent is 2.06-2.78 mg/g by optimizing an extraction process; in addition, the Tibetan medicine composition provided by the invention has a good inhibition effect on ten microbial bacteria such as escherichia coli, candida albicans, staphylococcus aureus, bacillus subtilis, propionibacterium acnes, streptococcus mutans, salmonella enteritidis, pseudomonas aeruginosa, porphyromonas gingivalis and staphylococcus epidermidis, and has universal antibacterial activity; the method can be widely applied to antibacterial products in various fields.
Resumen de: KR20260011330A
본 발명은 프로테오즈 펩톤, D-소르비톨, 페놀 레드, 뉴트럴 레드, 크리스탈 바이올렛 및 사카로스를 포함하는 살모넬라 균의 선별 또는 선택 배지 조성물에 관한 것이다.
Resumen de: CN121380063A
The invention discloses CRISPR (clustered regularly interspaced short palindromic repeats)-based food-borne pathogenic bacterium crRNA (crRNA), a kit, a multiple detection method and application, and belongs to the technical field of food safety detection. Specific genes of salmonella typhimurium (invA), staphylococcus aureus (femB), listeria monocytogenes (hly) and vibrio parahaemolyticus (toxR) are used as target genes for detection, an RPA primer and crRNA are designed for each gene, a quadruple RPA-CRISPR reaction system is established, the dual technical advantages of RPA amplification and a CRISPR system are combined, the detection sensitivity of the method is smaller than 10 copies/L, the detection time is greatly shortened, and the detection efficiency is greatly improved. And visual detection is realized through a blue light detector.
Resumen de: CN120917035A
The present invention relates to protein bacteriocins (PBs) as therapeutic agents, and in particular to protein complexes comprising two or more PB molecules associated with a protein scaffold comprising a homologous immune protein domain against an effector portion of the corresponding PB. In particular, the present invention provides an antibacterial protein complex comprising: (a) a first PB molecule and a second PB molecule; and (b) an immune protein scaffold comprising a first immune protein domain and a second immune protein domain; wherein the first immune protein domain and the second immune protein domain are non-covalently bound to the first PB molecule and the second PB molecule, respectively.
Resumen de: CN121380294A
The invention discloses a salmonella typhimurium fluorescence detection method based on dual signal amplification, and relates to the technical field of microbiological detection.The method comprises the specific steps that firstly, SNA1 and SNA2 probes are constructed, related chains are co-modified on the surfaces of gold nanoparticles through a freezing method, and part of sequences are closed; then preparing an Apt.-F compound; then incubating the sample and the compound; then starting a dual signal amplification reaction; and finally, detecting the fluorescence intensity by using a fluorospectro photometer, and quantifying the salmonella typhimurium according to the relationship between the fluorescence intensity and the bacterium concentration. According to the invention, two kinds of functionalized SNA probes are constructed, the aptamer and DNAzyme are arranged, a dual signal amplification pathway is established, target bacteria are accurately identified through the aptamer, a trigger chain is released to start chain replacement, a fluorophore is released, the detection sensitivity is improved, the probe design is optimized to ensure specificity, the process is simplified, and rapid quantification is realized; an efficient scheme is provided for trace pathogenic bacterium detection.
Resumen de: US20260022888A1
The purpose of the (Fort's Gloves, Dry and Hold Pail) is to prevent moisture that causes the spread of bacteria from restrooms that is the cause of influenza, streptococcus, E coli, Hepatitis, MRSA, Salmonella, Shigella, and Norovirus. The pail is a new creation except for the authentic manuscript and cursive text. There is a distinct difference from the usual and traditional utility pails each community uses, because of the holder for the moisture elimination products that prevents contaminated water from spilling to the floor. Fecal and Trash water could potentially cause mildew growth on the gloves and the pail. The Dry & Hold container overall is a new Invention and a cleaner choice for the environment because the design prevents disease, foul odors.
Resumen de: US20260022390A1
The present disclosure relates to a recombinant expression vector for secretion of melittin and an attenuated Salmonella strain transformed therewith, and provides an attenuated Salmonella strain transformed with a recombinant expression vector including an flgM gene and a melittin gene, an anticancer pharmaceutical composition including the attenuated Salmonella strain as an active ingredient, and a recombinant expression vector capable of improving the secretion ability of melittin.
Resumen de: US20260021146A1
The present disclosure relates to a recombinant expression vector for secretion of a VC1 protein and an attenuated Salmonella strain transformed therewith, and provides: a recombinant expression vector comprising an flgM gene, a VC1 gene, and an flhDC gene; an attenuated Salmonella strain transformed therewith; and a pharmaceutical composition for cancer treatment, comprising the attenuated Salmonella strain.
Resumen de: CN120826235A
Techniques for providing immunogenic compositions (e.g., vaccines) and methods of inducing an immune response in a subject in need thereof are provided.
Resumen de: CN121343852A
The invention provides a low-toxicity and high-tumor targeting salmonella typhimurium strain. According to the low-toxicity and high-tumor targeting salmonella typhimurium strain, an msbB gene segment (STM142297) and a hemA gene segment (STM142147) are deleted from the strain; the nucleotide sequence of the msbB gene segment is as shown in SEQ ID No. 1, and the nucleotide sequence of the hemA gene segment is as shown in SEQ ID No. 2; the bacterial strain is classified and named as salmonella typhimurium, and is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms, the preservation number is CGMCC No.34793, and the preservation time is June 9, 2025. The obtained strain is low in toxicity, low in damage to hosts, high in tumor targeting performance and suitable for being used as a tumor treatment carrier.
Resumen de: US20260015620A1
Methods for making synthetic gene clusters are described.
Resumen de: CN121312604A
The invention discloses application of tetrathiafulvalene as a bactericide in bacterial diseases and the bactericide, and relates to the technical field of food industry and agriculture. The invention relates to application of tetrathiafulvalene as a bactericide in bacterial diseases and the bactericide. The bacterial diseases comprise diseases caused by plant pathogenic bacteria and/or food-borne pathogenic bacteria. The invention aims to solve the problem of disease control in food industry and agriculture, and provides new application of tetrathiafulvalene in bacterial diseases. The invention provides application of tetrathiafulvalene in preventing and treating agricultural bacterial diseases caused by rice bacterial blight pathogenic bacteria, citrus ulcer pathogenic bacteria and pseudomonas solanacearum pathogenic bacteria and food pollution caused by escherichia coli, bacillus cereus, listeria monocytogenes, salmonella enteritidis and the like.
Resumen de: CN121320582A
The invention discloses a swine salmonella primer composition, a kit and application, the primer composition comprises a wzy154 upstream primer, a wzy154 downstream primer, a donor probe and a receptor probe, and further comprises an ST typing primer capable of amplifying aroC, dnaN, purE, hemD, thrA, hisD and sucA. The primer composition can be used for identifying the serotype of the swine salmonella, and compared with a slide agglutination test, the primer composition is simple and convenient to operate, short in time consumption and low in requirements on experience and operation level of experimenters, and has remarkable cost and flux advantages. The ST typing primer is further integrated by optimizing the primer composition, and PCR independent amplification of seven housekeeping genes is optimized into five reactions, so that the typing efficiency is remarkably improved, and epidemiological monitoring and evolution research are facilitated.
Resumen de: CN121320173A
The invention provides bacillus velezensis SE1318 and application thereof, and belongs to the technical field of microorganisms. The bacillus velezensis SE1318 provided by the invention is preserved in the China General Microbiological Culture Collection Center (CGMCC), and the preservation number of the bacillus velezensis SE1318 is CGMCC No. 35354. The strain has a remarkable inhibition effect on various common food-borne pathogenic bacteria such as staphylococcus aureus, listeria monocytogenes, escherichia coli, salmonella and botrytis cinerea.
Resumen de: CN121318845A
The invention provides a fluorenyl alcohol derivative which can be used as an antibiotic adjuvant with a broad-spectrum synergistic effect. According to the compound, bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are taken as targets, and a series of fluorenyl alcohol derivatives targeting the bacteria outer membrane asymmetric protein MlaC and phospholipase A1 PldA are obtained through screening. The preferable compound WTU-15 can improve the antibacterial activity of antibiotics such as polymyxin, cefepime, tetracycline and the like on negative bacteria such as sensitive and drug-resistant escherichia coli, salmonella, klebsiella pneumoniae, acinetobacter baumannii and the like, and can also improve the in-vivo treatment effect of cefepime on mice infected by the drug-resistant acinetobacter baumannii. And the visceral organs of the mice survived after administration have fewer bacteria, and the mice are better after being healed. Normal physiological and visceral organ functions of the mouse are not affected by single and continuous administration of the WTU-15.
Resumen de: CN121313602A
The invention discloses a yeast microcapsule encapsulated modified drug-loaded silicone grease body as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. The preparation method of the yeast microcapsule encapsulated modified drug-loaded silicone grease comprises the following steps: mixing disulfide bond modified dendritic mesoporous silica, an antibacterial drug, an anti-inflammatory drug and water to prepare drug-loaded dendritic mesoporous silica; the preparation method comprises the following steps: preparing drug-loaded dendritic mesoporous silica, coating the surface of the drug-loaded dendritic mesoporous silica with attenuated salmonella outer membrane vesicles, modifying the surface of the drug-loaded dendritic mesoporous silica with polyethyleneimine and hyaluronic acid, and finally coating with yeast microcapsules to obtain the modified drug-loaded silicone grease encapsulated by the yeast microcapsules. The modified drug-loaded silicone grease can achieve antibacterial, anti-inflammatory and intestinal flora recovery, provides an alternative scheme for traditional antibiotic treatment, and effectively solves the problems that the antibiotic treatment effect on animal salmonella enterica infection is poor and the like.
Resumen de: CN121320400A
The invention discloses a stable and antibiotic-free plasmid expression system and application thereof in preparation of antitumor drugs. The plasmid expression system comprises a replicon, a regulatable promoter, a ribosome binding site RBS and an axe/txe toxin-antitoxin stabilization module, and the plasmid expression system can realize long-term stable expression of exogenous genes under the antibiotic-free condition. The replicon is selected from one or a combination of more of pUC, pMB1, p15A or pSC101; the promoter is selected from one or a combination of more of J23100, J23150 or J23112, and the RBS is selected from one or a combination of more of B0032, B0033 or B0034. According to the invention, an antibiotic-free and lasting plasmid platform is established for salmonella-based therapy, and a framework, synthetic biology and cancer treatment opportunity are provided for reliable gene delivery in vivo.
Resumen de: CN121320356A
The invention discloses a nucleic acid aptamer for detecting high-toxicity klebsiella pneumoniae as well as application, a system and a method of the nucleic acid aptamer, and belongs to the field of microbiological detection. The nucleic acid aptamer for detecting the high-virulence klebsiella pneumoniae comprises an HVKpApt-2 of which the sequence is as shown in SEQ ID NO.1, an HVKpApt-7 of which the sequence is as shown in SEQ ID NO.2, and an HVKpApt-12 of which the sequence is as shown in SEQ ID NO.3. The nucleic acid aptamer for detecting the high-virulence klebsiella pneumoniae is used for detecting the high-virulence klebsiella pneumoniae. Based on the nucleic acid aptamer, the invention also provides a system and a method for detecting high-toxicity klebsiella pneumoniae. The nucleic acid aptamer, the system and the method for detecting the high-toxicity klebsiella pneumoniae have the characteristics of high specificity and high sensitivity, and the high-toxicity klebsiella pneumoniae can be effectively and accurately detected from a clinical sample.
Resumen de: CN121320595A
The invention relates to the field of biological detection, in particular to a primer probe set, a detection reagent and application of the primer probe set and the detection reagent in detection of virulent pathogenic bacteria. The invention provides a primer probe group. The primer probe group comprises a primer probe group used for amplifying bacillus anthracis, Francisella tularensis, bacillus plague, rhinotrichum-like bacteria, brucella, vibrio cholerae, salmonella typhimurium and staphylococcus aureus, wherein the primer probe group is used for amplifying bacillus anthracis, Francisella tularensis, bacillus plague, rhinotrichum-like bacteria, brucella, vibrio cholerae and salmonella typhimurium. The invention establishes a primer probe combination for rapidly and sensitively detecting various virulent pathogenic bacteria and a kit thereof, aiming at eight virulent pathogenic bacteria such as bacillus anthracis, Francisella tularensis, bacillus plague, rhinotrichum, vibrio cholerae, brucella, salmonella typhimurium and staphylococcus aureus. The kit is stored in a freeze-dried state, adaptive sample lysate can directly expand different types of samples, and the kit has the advantages of being good in specificity, high in sensitivity, short in detection time, good in accuracy, good in stability after redissolution and good in compatibility.
Resumen de: CN121294483A
The invention discloses a preparation method and application of salmonella choleraesuis bionic vesicles capable of being used for oral delivery of double antigens, and relates to the field of vaccines.Lipid A of a salmonella choleraesuis attenuated strain SC014 is modified through a genetic engineering technology, low-endotoxin salmonella choleraesuis engineering bacteria are obtained, then SpyCatcher and SpG are expressed on the surfaces of the salmonella choleraesuis engineering bacteria at the same time through ClyA, and the salmonella choleraesuis bionic vesicles are obtained. According to the present invention, the subunit vaccine model GDH-SpyTag and gD-Fc of the clinically common mixed infection pathogen Streptococcus suis and Pseudorabies virus (PRV) can be respectively coupled, and the negative electricity characteristic of the surface of the subunit vaccine model GDH-SpyTag and gD-Fc are used to wrap the subunit vaccine model GDH-SpyTag and gD-Fc by using the cationic compound COS so as to protect the antigen from being damaged by the gastrointestinal tract environment after the oral immunization; and the presentation of the antigen to digestive tract mucosa immune cells is promoted.
Resumen de: CN121293286A
The invention discloses an antibacterial peptide sesquidendrin and an application of the antibacterial peptide sesquidendrin. The invention specifically relates to eight sesquistigma polypeptide compounds. The compounds 1-8 show different degrees of antibacterial activity, the compound 2 has broad-spectrum antibacterial activity, the minimum inhibitory concentration of the compound 2 to staphylococcus aureus ATCC 6538 and bacillus cereus CMCC (B) 63301 reaches 20 mu g/mL, and the MIC value of the compound 2 to enterococcus faecium 160119481, salmonella typhimurium CMCC (B) 50071 and salmonella typhimurium CMCC (B) 50115 is 40 mu g/mL. As staphylococcus, bacillus, enterococcus and salmonella bacteria are common food-borne pathogenic bacteria which seriously threaten food safety, the compounds 1-8 can be used for preparing novel antibacterial peptides which are applied to the field of food safety preservation.
Resumen de: CN121294205A
The invention relates to the technical field of microorganisms, in particular to a complex microbial inoculant for resisting salmonella infection and application of the complex microbial inoculant. The invention provides a microbial composition for resisting salmonella infection. The microbial composition comprises lactobacillus reuteri, lactobacillus mucosa, lactobacillus plantarum, lactobacillus bulgaricus and pediococcus pentosaceus. Results of the embodiment of the invention show that the complex microbial inoculant provided by the invention has an excellent anti-salmonella typhimurium effect, and only the anti-salmonella typhimurium effect of the complex microbial inoculant in a specific proportion provided by the invention is optimal; meanwhile, the complex microbial inoculant can effectively relieve the harm of salmonella typhimurium to chickens, improve the growth performance of the chickens and improve the immunity of the chickens. The invention provides a new prevention and treatment thought for salmonella.
Nº publicación: CN121294254A 09/01/2026
Solicitante:
HEBEI NORMAL UNIV OF SCIENCE AND TECHNOLOGY
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Resumen de: CN121294254A
The invention relates to the technical field of microorganisms, in particular to lactobacillus johnsonii D8, application thereof and a probiotic agent. The lactobacillus johnsonii D8 is preserved in the China General Microbiological Culture Collection Center (CGMCC) on August 14, 2025, and the preservation number is CGMCC No.35619. The lactobacillus johnsonii D8 is a lactobacillus johnsonii strain. The lactobacillus johnsonii D8 provided by the invention can reduce the death rate of salmonella to the domestic pigeons after being drenched into the domestic pigeons, obviously alleviates the spleen index reduction and the immune globulin IgA reduction in serum caused by the salmonella, reduces the abundance of pathogenic bacteria in intestinal flora, and has a good probiotic effect on the domestic pigeons.
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